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Karin Eidne

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Matthew B Dalrymple; Werner C Jaeger; Karin A Eidne; Kevin D G Pfleger
Temporal profiling of orexin receptor-arrestin-ubiquitin complexes reveals differences between receptor subtypes.
Heng B See; Ruth M Seeber; Martina Kocan; Karin A Eidne; Kevin D G Pfleger
Application of G protein-coupled receptor-heteromer identification technology to monitor β-arrestin recruitment to G protein-coupled receptor heteromers.
Martina Kocan; Heng B See; Natália G Sampaio; Karin A Eidne; Brian J Feldman; Kevin D G Pfleger
Agonist-independent interactions between beta-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis.

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All Publications

2011: Matthew B Dalrymple; Werner C Jaeger; Karin A Eidne; Kevin D G Pfleger
Temporal profiling of orexin receptor-arrestin-ubiquitin complexes reveals differences between receptor subtypes.
The Journal of biological chemistry 2011;286(19):16726-33.
2011: Heng B See; Ruth M Seeber; Martina Kocan; Karin A Eidne; Kevin D G Pfleger
Application of G protein-coupled receptor-heteromer identification technology to monitor β-arrestin recruitment to G protein-coupled receptor heteromers.
Assay and drug development technologies 2011;9(1):21-30.
2009: Martina Kocan; Heng B See; Natália G Sampaio; Karin A Eidne; Brian J Feldman; Kevin D G Pfleger
Agonist-independent interactions between beta-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis.
Molecular endocrinology (Baltimore, Md.) 2009;23(4):559-71.
2008: Martina Kocan; Heng B See; Ruth M Seeber; Karin A Eidne; Kevin D G Pfleger
Demonstration of improvements to the bioluminescence resonance energy transfer (BRET) technology for the monitoring of G protein-coupled receptors in live cells.
Journal of biomolecular screening 2008;13(9):888-98.
2008: Matthew B Dalrymple; Kevin D G Pfleger; Karin A Eidne
G protein-coupled receptor dimers: functional consequences, disease states and drug targets.
Pharmacology & therapeutics 2008;118(3):359-71.
2008: Aron Chakera; Ruth M Seeber; Alison E John; Karin A Eidne; David Greaves
The duffy antigen/receptor for chemokines exists in an oligomeric form in living cells and functionally antagonizes CCR5 signaling through hetero-oligomerization.
Molecular pharmacology 2008;73(5):1362-70.
2007: Kevin D G Pfleger; M B Dalrymple; Jasmin R Dromey; Karin A Eidne
Monitoring interactions between G-protein-coupled receptors and beta-arrestins.
Biochemical Society transactions 2007;35(Pt 4):764-6.
2006: Kevin D G Pfleger; Jasmin R Dromey; Matthew B Dalrymple; Esther M L Lim; Walter G Thomas; Karin A Eidne
Extended bioluminescence resonance energy transfer (eBRET) for monitoring prolonged protein-protein interactions in live cells.
Cellular signalling 2006;18(10):1664-70.
2006: Kevin D G Pfleger; Karin A Eidne
Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET).
Nature methods 2006;3(3):165-74.
2006: Kevin D G Pfleger; Ruth M Seeber; Karin A Eidne
Bioluminescence resonance energy transfer (BRET) for the real-time detection of protein-protein interactions.
Nature protocols 2006;1(1):337-45.
2005: Richard J Brown; Julian J Adams; Rebecca A Pelekanos; Yu Wan; William J McKinstry; Kathryn Palethorpe; Ruth M Seeber; Thea A Monks; Karin A Eidne; Michael W Parker; Michael J Waters
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer.
Nature structural & molecular biology 2005;12(9):814-21.
2005: Diem T Dinh; Hongwei Qian; Ruth M Seeber; Esther Lim; Kevin D G Pfleger; Karin A Eidne; Walter G Thomas
Helix I of beta-arrestin is involved in postendocytic trafficking but is not required for membrane translocation, receptor binding, and internalization.
Molecular pharmacology 2005;67(2):375-82.
2005: Kevin D G Pfleger; Karin A Eidne
Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells.
The Biochemical journal 2005;385(Pt 3):625-37.
2005: Song Zhang; Dominique Blache; Philip E Vercoe; Clare L Adam; Margaret A Blackberry; Patricia A Findlay; Karin A Eidne; Graeme B Martin
Expression of orexin receptors in the brain and peripheral tissues of the male sheep.
Regulatory peptides 2005;124(1-3):81-7.
2004: Amelia K Scaffidi; Nenad Petrovic; Yuben P Moodley; Mirjana Fogel-Petrovic; Karen M Kroeger; Ruth M Seeber; Karin A Eidne; Philip J Thompson; Darryl A Knight
alpha(v)beta(3) Integrin interacts with the transforming growth factor beta (TGFbeta) type II receptor to potentiate the proliferative effects of TGFbeta1 in living human lung fibroblasts.
The Journal of biological chemistry 2004;279(36):37726-33.
2004: Bryan K Ward; Aaron Magno; Elizabeth A Davis; Aylin C Hanyaloglu; Bronwyn G A Stuckey; Mark Burrows; Karin A Eidne; Adrian K Charles; Thomas Ratajczak
Functional deletion of the calcium-sensing receptor in a case of neonatal severe hyperparathyroidism.
The Journal of clinical endocrinology and metabolism 2004;89(8):3721-30.
2004: Kevin D G Pfleger; Karen M Kroeger; Karin A Eidne
Receptors for hypothalamic releasing hormones TRH and GnRH: oligomerization and interactions with intracellular proteins.
Seminars in cell & developmental biology 2004;15(3):269-80.
2004: Martina Schröder; Karen M Kroeger; Hans-Dieter Volk; Karin A Eidne; Gerald Grütz
Preassociation of nonactivated STAT3 molecules demonstrated in living cells using bioluminescence resonance energy transfer: a new model of STAT activation?
Journal of leukocyte biology 2004;75(5):792-7.
2004: Karen M Kroeger; Karin A Eidne
Study of G-protein-coupled receptor-protein interactions by bioluminescence resonance energy transfer.
Methods in molecular biology (Clifton, N.J.) 2004;259():323-33.
2004: Lauren E C Miles; Aylin C Hanyaloglu; Jasmin R Dromey; Kevin D G Pfleger; Karin A Eidne
Gonadotropin-releasing hormone receptor-mediated growth suppression of immortalized LbetaT2 gonadotrope and stable HEK293 cell lines.
Endocrinology 2004;145(1):194-204.
2003: Karen M Kroeger; Kevin D G Pfleger; Karin A Eidne
G-protein coupled receptor oligomerization in neuroendocrine pathways.
Frontiers in neuroendocrinology 2003;24(4):254-78.
2003: Kevin D G Pfleger; Karin A Eidne
New technologies: bioluminescence resonance energy transfer (BRET) for the detection of real time interactions involving G-protein coupled receptors.
Pituitary 2003;6(3):141-51.
2002: Aylin C Hanyaloglu; Ruth M Seeber; Trudy A Kohout; Robert J Lefkowitz; Karin A Eidne
Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.
The Journal of biological chemistry 2002;277(52):50422-30.
2002: Karin A Eidne; Karen M Kroeger; Aylin C Hanyaloglu
Applications of novel resonance energy transfer techniques to study dynamic hormone receptor interactions in living cells.
Trends in endocrinology and metabolism: TEM 2002;13(10):415-21.
2002: Nithiananthan Asokananthan; Peter T Graham; David J Stewart; Anthony J Bakker; Karin A Eidne; Philip J Thompson; Geoffrey A Stewart
House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4572-8.
2001: Aylin C Hanyaloglu; Milka Vrecl; Karen M Kroeger; Lauren E C Miles; H Qian; Walter G Thomas; Karin A Eidne
Casein kinase II sites in the intracellular C-terminal domain of the thyrotropin-releasing hormone receptor and chimeric gonadotropin-releasing hormone receptors contribute to beta-arrestin-dependent internalization.
The Journal of biological chemistry 2001;276(21):18066-74.
2001: Karen M Kroeger; Aylin C Hanyaloglu; Ruth M Seeber; Lauren E C Miles; Karin A Eidne
Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer.
The Journal of biological chemistry 2001;276(16):12736-43.
2000: Karin A Eidne; C C Henery; R J Aitken
Selection of peptides targeting the human sperm surface using random peptide phage display identify ligands homologous to ZP3.
Biology of reproduction 2000;63(5):1396-402.
2000: Milka Vrecl; Anders Heding; Aylin C Hanyaloglu; PL Taylor; Karin A Eidne
Internalization kinetics of the gonadotropin-releasing hormone (GnRH) receptor.
Pflügers Archiv : European journal of physiology 2000;439(3 Suppl):R19-20.
2000: Anders Heding; Milka Vrecl; Aylin C Hanyaloglu; Robin Sellar; PL Taylor; Karin A Eidne
The rat gonadotropin-releasing hormone receptor internalizes via a beta-arrestin-independent, but dynamin-dependent, pathway: addition of a carboxyl-terminal tail confers beta-arrestin dependency.
Endocrinology 2000;141(1):299-306.
1999: B Byrne; A McGregor; PL Taylor; Robin Sellar; FE Rodger; Hamish M Fraser; Karin A Eidne
Isolation and characterisation of the marmoset gonadotrophin releasing hormone receptor: Ser(140) of the DRS motif is substituted by Phe.
The Journal of endocrinology 1999;163(3):447-56.
1999: Marion Blomenröhr; Anders Heding; Robin Sellar; Rob Leurs; Jan Bogerd; Karin A Eidne; Gary B Willars
Pivotal role for the cytoplasmic carboxyl-terminal tail of a nonmammalian gonadotropin-releasing hormone receptor in cell surface expression, ligand binding, and receptor phosphorylation and internalization.
Molecular pharmacology 1999;56(6):1229-37.
1999: Gary B Willars; Anders Heding; Milka Vrecl; Robin Sellar; Marion Blomenröhr; Stefan R Nahorski; Karin A Eidne
Lack of a C-terminal tail in the mammalian gonadotropin-releasing hormone receptor confers resistance to agonist-dependent phosphorylation and rapid desensitization.
The Journal of biological chemistry 1999;274(42):30146-53.
1998: Milka Vrecl; L Anderson; Aylin C Hanyaloglu; A M McGregor; A D Groarke; G Milligan; PL Taylor; Karin A Eidne
Agonist-induced endocytosis and recycling of the gonadotropin-releasing hormone receptor: effect of beta-arrestin on internalization kinetics.
Molecular endocrinology (Baltimore, Md.) 1998;12(12):1818-29.
1998: B Byrne; S Klahn; PL Taylor; Karin A Eidne
Functional analysis of GnRH receptor ligand binding using biotinylated GnRH derivatives.
Molecular and cellular endocrinology 1998;144(1-2):11-9.
1998: Anders Heding; Milka Vrecl; Jan Bogerd; A McGregor; Robin Sellar; PL Taylor; Karin A Eidne
Gonadotropin-releasing hormone receptors with intracellular carboxyl-terminal tails undergo acute desensitization of total inositol phosphate production and exhibit accelerated internalization kinetics.
The Journal of biological chemistry 1998;273(19):11472-7.
1997: J V Cook; Karin A Eidne
An intramolecular disulfide bond between conserved extracellular cysteines in the gonadotropin-releasing hormone receptor is essential for binding and activation.
Endocrinology 1997;138(7):2800-6.
1996: J V Cook; A McGregor; T Lee; G Milligan; Karin A Eidne
A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor.
Endocrinology 1996;137(7):2851-8.
1996: L Anderson; Stephen G Hillier; Karin A Eidne; F Miro
GnRH-induced calcium mobilisation and inositol phosphate production in immature and mature rat ovarian granulosa cells.
The Journal of endocrinology 1996;149(3):449-56.
1996: Petr Svoboda; G D Kim; MA Grassie; Karin A Eidne; Graeme Milligan
Thyrotropin-releasing hormone-induced subcellular redistribution and down-regulation of G11alpha: analysis of agonist regulation of coexpressed G11alpha species variants.
Molecular pharmacology 1996;49(4):646-55.
1996: E Faccenda; S Melmed; J S Bevan; Karin A Eidne
Structure of the thyrotrophin-releasing hormone receptor in human pituitary adenomas.
Clinical endocrinology 1996;44(3):341-7.
1996: Hamish M Fraser; Robin Sellar; Peter J Illingworth; Karin A Eidne
GnRH receptor mRNA expression by in-situ hybridization in the primate pituitary and ovary.
Molecular human reproduction 1996;2(2):117-21.
1995: L Anderson; A McGregor; J V Cook; E Chilvers; Karin A Eidne
Rapid desensitization of GnRH-stimulated intracellular signalling events in alpha T3-1 and HEK-293 cells expressing the GnRH receptor.
Endocrinology 1995;136(11):5228-31.
1995: L Anderson; C L Alexander; E Faccenda; Karin A Eidne
Rapid desensitization of the thyrotropin-releasing hormone receptor expressed in single human embryonal kidney 293 cells.
The Biochemical journal 1995;311 ( Pt 2)():385-92.
1995: T W Lee; L A Anderson; Karin A Eidne; Graeme Milligan
Comparison of the signalling properties of the long and short isoforms of the rat thyrotropin-releasing-hormone receptor following expression in rat 1 fibroblasts.
The Biochemical journal 1995;310 ( Pt 1)():291-8.
1995: T W Lee; Karin A Eidne; Graeme Milligan
Signalling characteristics of thyrotropin releasing hormone (TRH) receptor isoforms.
Biochemical Society transactions 1995;23(1):11S.
1995: P F Whitelaw; Karin A Eidne; Robin Sellar; C D Smyth; Stephen G Hillier
Gonadotropin-releasing hormone receptor messenger ribonucleic acid expression in rat ovary.
Endocrinology 1995;136(1):172-9.
1994: G D Kim; I Craig Carr; L A Anderson; J Zabavnik; Karin A Eidne; Graeme Milligan
The long isoform of the rat thyrotropin-releasing hormone receptor down-regulates Gq proteins.
The Journal of biological chemistry 1994;269(31):19933-40.
1994: N Morrison; S M Duthie; E Boyd; Karin A Eidne; J Michael Connor
Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization.
Human genetics 1994;93(6):716-8.
1994: N Morrison; Robin Sellar; E Boyd; Karin A Eidne; J Michael Connor
Assignment of the gene encoding the human gonadotropin-releasing hormone receptor to 4q13.2-13.3 by fluorescence in situ hybridization.
Human genetics 1994;93(6):714-5.
1994: Karin A Eidne; J Zabavnik; W T Allan; Anthony Trewavas; N D Read; L Anderson
Calcium waves and dynamics visualized by confocal microscopy in Xenopus oocytes expressing cloned TRH receptors.
Journal of neuroendocrinology 1994;6(2):173-8.
1993: J V Cook; E Faccenda; L Anderson; G G Couper; Karin A Eidne; PL Taylor
Effects of Asn87 and Asp318 mutations on ligand binding and signal transduction in the rat GnRH receptor.
The Journal of endocrinology 1993;139(3):R1-4.
1993: S M Duthie; PL Taylor; Karin A Eidne
Characterization of the mouse thyrotrophin-releasing hormone receptor gene: an exon corresponds to a deletion in the rat cDNA.
Journal of molecular endocrinology 1993;11(2):141-9.
1993: J Zabavnik; W X Wu; Karin A Eidne; Alan S McNeilly
Dopamine D2 receptor mRNA in the pituitary during the oestrous cycle, pregnancy and lactation in the rat.
Molecular and cellular endocrinology 1993;95(1-2):121-8.
1993: S M Duthie; PL Taylor; L Anderson; J Cook; Karin A Eidne
Cloning and functional characterisation of the human TRH receptor.
Molecular and cellular endocrinology 1993;95(1-2):R11-5.
1993: J Brooks; PL Taylor; Philippa Saunders; Karin A Eidne; W J Struthers; Alan S McNeilly
Cloning and sequencing of the sheep pituitary gonadotropin-releasing hormone receptor and changes in expression of its mRNA during the estrous cycle.
Molecular and cellular endocrinology 1993;94(2):R23-7.
1993: J Zabavnik; G Arbuthnott; Karin A Eidne
Distribution of thyrotrophin-releasing hormone receptor messenger RNA in rat pituitary and brain.
Neuroscience 1993;53(3):877-87.
1993: Robin Sellar; PL Taylor; R F Lamb; J Zabavnik; L Anderson; Karin A Eidne
Functional expression and molecular characterization of the thyrotrophin-releasing hormone receptor from the rat anterior pituitary gland.
Journal of molecular endocrinology 1993;10(2):199-206.
1993: L Anderson; G Milligan; Karin A Eidne
Characterization of the gonadotrophin-releasing hormone receptor in alpha T3-1 pituitary gonadotroph cells.
The Journal of endocrinology 1993;136(1):51-8.
1992: Karin A Eidne; Robin Sellar; G Couper; L Anderson; PL Taylor
Molecular cloning and characterisation of the rat pituitary gonadotropin-releasing hormone (GnRH) receptor.
Molecular and cellular endocrinology 1992;90(1):R5-9.
1992: L Anderson; J Hoyland; W T Mason; Karin A Eidne
Characterization of the gonadotrophin-releasing hormone calcium response in single alpha T3-1 pituitary gonadotroph cells.
Molecular and cellular endocrinology 1992;86(3):167-75.
1991: Karin A Eidne; J Zabavnik; T Peters; S Yoshida; L Anderson; PL Taylor
Cloning, sequencing and tissue distribution of a candidate G protein-coupled receptor from rat pituitary gland.
FEBS letters 1991;292(1-2):243-8.
1990: E Jean Wickings; Karin A Eidne; Alan F Dixson; Stephen G Hillier
Gonadotropin-releasing hormone analogs inhibit primate granulosa cell steroidogenesis via a mechanism distinct from that in the rat.
Biology of reproduction 1990;43(2):305-11.
1989: Karin A Eidne; PL Taylor; J Zabavnik; Philippa Saunders; J D Inglis
D2 receptor, a missing exon.
Nature 1989;342(6252):865.
1989: S Yoshida; S Plant; PL Taylor; Karin A Eidne
Chloride channels mediate the response to gonadotropin-releasing hormone (GnRH) in Xenopus oocytes injected with rat anterior pituitary mRNA.
Molecular endocrinology (Baltimore, Md.) 1989;3(12):1953-60.
1988: Karin A Eidne; A I McNiven; PL Taylor; S Plant; C R House; D W Lincoln; S Yoshida
Functional expression of rat pituitary gonadotrophin-releasing hormone receptors in Xenopus oocytes.
Journal of molecular endocrinology 1988;1(3):R9-12.
1987: Stephen G Hillier; C G Tsonis; E Jean Wickings; Karin A Eidne
Inhibition of FSH-stimulated granulosa cell function by a synthetic fragment of the porcine inhibin alpha-subunit: evidence for involvement of GnRH receptors.
The Journal of endocrinology 1987;113(2):R3-5.