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León Eijsman

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Koba Kupreishvili; Alexi Baidoshvili; Mimi ter Weeme; M A J M Huybregts; P A J Krijnen; Victor W M van Hinsbergh; Wim Stooker; León Eijsman; Hans W M Niessen
Degeneration and atherosclerosis inducing increased deposition of type IIA secretory phospholipase A2, C-reactive protein and complement in aortic valves cause neutrophilic granulocyte influx.
M ter Weeme; A B A Vonk; K Kupreishvili; M van Ham; S Zeerleder; D Wouters; Wim Stooker; León Eijsman; V W M Van Hinsbergh; P A J Krijnen; Hans W M Niessen
Activated complement is more extensively present in diseased aortic valves than naturally occurring complement inhibitors: a sign of ongoing inflammation.
K Kupreishvili; M ter Weeme; Servaas A Morré; Adriaan J C van den Brule; M A J M Huybregts; Paul H A Quax; J ten Velden; Victor W M van Hinsbergh; Wim Stooker; León Eijsman; Hans W M Niessen
Increased infiltration of Chlamydophila pneumoniae in the vessel wall of human veins after perfusion.

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All Publications

2011: Koba Kupreishvili; Alexi Baidoshvili; Mimi ter Weeme; M A J M Huybregts; P A J Krijnen; Victor W M van Hinsbergh; Wim Stooker; León Eijsman; Hans W M Niessen
Degeneration and atherosclerosis inducing increased deposition of type IIA secretory phospholipase A2, C-reactive protein and complement in aortic valves cause neutrophilic granulocyte influx.
The Journal of heart valve disease 2011;20(1):29-36.
2010: M ter Weeme; A B A Vonk; K Kupreishvili; M van Ham; S Zeerleder; D Wouters; Wim Stooker; León Eijsman; V W M Van Hinsbergh; P A J Krijnen; Hans W M Niessen
Activated complement is more extensively present in diseased aortic valves than naturally occurring complement inhibitors: a sign of ongoing inflammation.
European journal of clinical investigation 2010;40(1):4-10.
2008: K Kupreishvili; M ter Weeme; Servaas A Morré; Adriaan J C van den Brule; M A J M Huybregts; Paul H A Quax; J ten Velden; Victor W M van Hinsbergh; Wim Stooker; León Eijsman; Hans W M Niessen
Increased infiltration of Chlamydophila pneumoniae in the vessel wall of human veins after perfusion.
European journal of clinical investigation 2008;38(7):462-8.
2007: Jeanette M van den Goor; Rienk Nieuwland; Wim van Oeveren; Peter M Rutten; Jan G P Tijssen; Chi M Hau; Augueste Sturk; León Eijsman; Bas A J M de Mol
Cell Saver device efficiently removes cell-derived microparticles during cardiac surgery.
The Journal of thoracic and cardiovascular surgery 2007;134(3):798-9.
2007: Jeanette M van den Goor; Rienk Nieuwland; Peter M Rutten; Jan G P Tijssen; Chi M Hau; Augueste Sturk; León Eijsman; Bas A J M de Mol
Retransfusion of pericardial blood does not trigger systemic coagulation during cardiopulmonary bypass.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2007;31(6):1029-36.
2007: Robert Tepaske; Henk te Velthuis; Heleen Oudemans-van Straaten; Patrick Bossuyt; Marcus Schultz; León Eijsman; Margreeth B Vroom
Glycine does not add to the beneficial effects of perioperative oral immune-enhancing nutrition supplements in high-risk cardiac surgery patients.
JPEN. Journal of parenteral and enteral nutrition 2007;31(3):173-80.
2006: Alexi Baidoshvili; P A J Krijnen; K Kupreishvili; C Ciurana; W Bleeker; Remco Nijmeijer; Cees A Visser; Frans C Visser; C J L M Meijer; Wim Stooker; León Eijsman; Victor W M van Hinsbergh; C Erik Hack; Hans W M Niessen; Casper G Schalkwijk
N(epsilon)-(carboxymethyl)lysine depositions in intramyocardial blood vessels in human and rat acute myocardial infarction: a predictor or reflection of infarction?
Arteriosclerosis, thrombosis, and vascular biology 2006;26(11):2497-503.
2006: Jeanette M van den Goor; Wim van Oeveren; Peter M Rutten; Jan G P Tijssen; León Eijsman
Adhesion of thrombotic components to the surface of a clinically used oxygenator is not affected by Trillium coating.
Perfusion 2006;21(3):165-72.
2005: Roel Vroege; Rien A J M Huybregts; Wim van Oeveren; Jan van Klarenbosch; Gerard Linley; Jihan Mutlu; Evert Jansen; Erik Hack; León Eijsman; Ch R H Wildevuur
The impact of heparin-coated circuits on hemodynamics during and after cardiopulmonary bypass.
Artificial organs 2005;29(6):490-7.
2005: Roel Vroege; Wim Stooker; Wim van Oeveren; Edwin W M Bakker; Rien A J M Huybregts; Jan van Klarenbosch; Gerard J van Kamp; C Erik Hack; León Eijsman; Charles R H Wildevuur
The impact of heparin coated circuits upon metabolism in vital organs: effect upon cerebral and renal function during and after cardiopulmonary bypass.
ASAIO journal (American Society for Artificial Internal Organs : 1992) 2005;51(1):103-9.
2004: Jeanette M van den Goor; Rienk Nieuwland; A van den Brink; Wim van Oeveren; Peter M Rutten; Jan G P Tijssen; León Eijsman
Reduced complement activation during cardiopulmonary bypass does not affect the postoperative acute phase response.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2004;26(5):926-31.
2004: Roel Vroege; Wim van Oeveren; Jan van Klarenbosch; Wim Stooker; M A J M Huybregts; C Erik Hack; L van Barneveld; León Eijsman; Charles R H Wildevuur
The impact of heparin-coated cardiopulmonary bypass circuits on pulmonary function and the release of inflammatory mediators.
Anesthesia and analgesia 2004;98(6):1586-94, table of contents.
2004: Alexi Baidoshvili; Hans W M Niessen; Wim Stooker; Rien A J M Huybregts; C Erik Hack; Jan A Rauwerda; Chris J L M Meijer; León Eijsman; Victor W M van Hinsbergh; Casper G Schalkwijk
N(omega)-(carboxymethyl)lysine depositions in human aortic heart valves: similarities with atherosclerotic blood vessels.
Atherosclerosis 2004;174(2):287-92.
2004: Marike van der Schaaf; Hester Vermeulen; Marja N Storm-Versloot; Astrid Goossens; Robert Simons; León Eijsman
Effectiveness of lactulose syrup after cardiac surgery.
Applied nursing research : ANR 2004;17(1):48-54.
2004: Roel Vroege; F te Meerman; León Eijsman; WR Wildevuur; Ch R H Wildevuur; Wim van Oeveren
Induction and detection of disturbed homeostasis in cardiopulmonary bypass.
Perfusion 2004;19(5):267-76.
2003: Wim Stooker; Murat Gök; Pieter Sipkema; Hans W M Niessen; Alexi Baidoshvili; Nico Westerhof; Evert K Jansen; Charles R H Wildevuur; León Eijsman
Pressure-diameter relationship in the human greater saphenous vein.
The Annals of thoracic surgery 2003;76(5):1533-8.
2003: Jeanette M van den Goor; Albert van den Brink; Rienk Nieuwland; Wim van Oeveren; Peter M Rutten; Robert Tepaske; Jan G P Tijssen; Augueste Sturk; Bas A J M de Mol; León Eijsman
Generation of platelet-derived microparticles in patients undergoing cardiac surgery is not affected by complement activation.
The Journal of thoracic and cardiovascular surgery 2003;126(4):1101-6.
2003: K N Sturk-Maquelin; Rienk Nieuwland; Fred P H T M Romijn; León Eijsman; C E Hack; Augueste Sturk
Pro- and non-coagulant forms of non-cell-bound tissue factor in vivo.
Journal of thrombosis and haemostasis : JTH 2003;1(9):1920-6.
2003: Wim Stooker; Hans W M Niessen; Evert K Jansen; J Fritz; WR Wildevuur; Victor W M van Hinsbergh; Ch R H Wildevuur; León Eijsman
Surgical sealant in the prevention of early vein graft injury in an ex vivo model.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2003;12(4):202-6.
2003: Ali Dodge-Khatami; Hans W M Niessen; Alexi Baidoshvili; T M van Gulik; M G Klein; León Eijsman; Bas A J M de Mol
Topical vascular endothelial growth factor in rabbit tracheal surgery: comparative effect on healing using various reconstruction materials and intraluminal stents.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2003;23(1):6-14.
2002: Wim Stooker; Hans W M Niessen; WR Wildevuur; Victor W M van Hinsbergh; J Fritz; Evert K Jansen; Ch R H Wildevuur; León Eijsman
Perivenous application of fibrin glue reduces early injury to the human saphenous vein graft wall in an ex vivo model.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2002;21(2):212-7.
2001: Jolanda van der Velden; Lucas J Klein; Ruud Zaremba; Nicky M Boontje; M A J M Huybregts; Wim Stooker; León Eijsman; JW de Jong; Cees A Visser; Frans C Visser; Ger J M Stienen
Effects of calcium, inorganic phosphate, and pH on isometric force in single skinned cardiomyocytes from donor and failing human hearts.
Circulation 2001;104(10):1140-6.
2001: Wim Stooker; Hans W M Niessen; Alexi Baidoshvili; WR Wildevuur; Victor W M van Hinsbergh; J Fritz; Charles R H Wildevuur; León Eijsman
Perivenous support reduces early changes in human vein grafts: studies in whole blood perfused human vein segments.
The Journal of thoracic and cardiovascular surgery 2001;121(2):290-7.
2001: Roel Vroege; M Wagemakers; Henk te Velthuis; E Bulder; Reggie C E Paulus; Rien A J M Huybregts; WR Wildevuur; León Eijsman; Wim van Oeveren; Ch R H Wildevuur
Comparison of three commercially available hollow fiber oxygenators: gas transfer performance and biocompatibility.
ASAIO journal (American Society for Artificial Internal Organs : 1992) 2001;47(1):37-44.
2000: KN Maquelin; Rienk Nieuwland; Eef G W M Lentjes; Anita N Böing; B Mochtar; León Eijsman; Augueste Sturk
Aprotinin administration in the pericardial cavity does not prevent platelet activation.
The Journal of thoracic and cardiovascular surgery 2000;120(3):552-7.
2000: Peter Bruins; Henk te Velthuis; A J Eerenberg-Belmer; A P Yazdanbakhsh; E M de Beaumont; León Eijsman; Adrianus Trouwborst; C Erik Hack
Heparin-protamine complexes and C-reactive protein induce activation of the classical complement pathway: studies in patients undergoing cardiac surgery and in vitro.
Thrombosis and haemostasis 2000;84(2):237-43.
1999: Jolanda van der Velden; Lucas J Klein; MW van der Bijl; M A J M Huybregts; Wim Stooker; J Witkop; León Eijsman; Cees A Visser; Frans C Visser; Ger J M Stienen
Isometric tension development and its calcium sensitivity in skinned myocyte-sized preparations from different regions of the human heart.
Cardiovascular research 1999;42(3):706-19.
1998: R G Speekenbrink; R M Bertina; F España; Charles R H Wildevuur; León Eijsman
Activation of the protein C system during cardiopulmonary bypass with and without aprotinin.
The Annals of thoracic surgery 1998;66(6):1998-2002.
1998: Michael J Jacobs; León Eijsman; SA Meylaerts; Ron Balm; Dink A Legemate; Peter de Haan; Cor Kalkman; Bas A J M de Mol
Reduced renal failure following thoracoabdominal aortic aneurysm repair by selective perfusion.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 1998;14(2):201-5.
1998: Jolanda van der Velden; Lucas J Klein; MW van der Bijl; M A J M Huybregts; Wim Stooker; J Witkop; León Eijsman; Cees A Visser; Frans C Visser; Ger J M Stienen
Force production in mechanically isolated cardiac myocytes from human ventricular muscle tissue.
Cardiovascular research 1998;38(2):414-23.
1998: KN Maquelin; René Berckmans; Rienk Nieuwland; Marianne C L Schaap; K ten Have; León Eijsman; Augueste Sturk
Disappearance of glycoprotein Ib from the platelet surface in pericardial blood during cardiopulmonary bypass.
The Journal of thoracic and cardiovascular surgery 1998;115(5):1160-5.
1998: Peter Bruins; Henk te Velthuis; Piet G M Jansen; León Eijsman; C Erik Hack
Biphasic release of secretory phospholipase A2 during and after cardiopulmonary bypass.
The Journal of thoracic and cardiovascular surgery 1998;115(4):949-51.
1998: Wim Stooker; Charles R H Wildevuur; Victor W M van Hinsbergh; León Eijsman
Let's understand nature better: de- and regeneration of autologous and artificial small caliber vascular grafts.
Artificial organs 1998;22(1):63-7.
1997: Peter Bruins; Henk te Velthuis; A P Yazdanbakhsh; Piet G M Jansen; F W van Hardevelt; E M de Beaumont; Charles R H Wildevuur; León Eijsman; Adrianus Trouwborst; C Erik Hack
Activation of the complement system during and after cardiopulmonary bypass surgery: postsurgery activation involves C-reactive protein and is associated with postoperative arrhythmia.
Circulation 1997;96(10):3542-8.
1997: Rienk Nieuwland; René Berckmans; R C Rotteveel-Eijkman; KN Maquelin; K J Roozendaal; Piet G M Jansen; K ten Have; León Eijsman; C Erik Hack; Augueste Sturk
Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant.
Circulation 1997;96(10):3534-41.
1997: Roel Vroege; Peter M Rutten; Cor Kalkman; T A Out; Piet G M Jansen; León Eijsman; B J de Mol; Charles R H Wildevuur
Biocompatibility of three different membrane oxygenators: effects on complement, neutrophil and monocyte activation.
Perfusion 1997;12(6):369-75.
1997: Q Li; Marike Feenstra; Martin Pfaffendorf; León Eijsman; Pieter A van Zwieten
Comparative vasoconstrictor effects of angiotensin II, III, and IV in human isolated saphenous vein.
Journal of cardiovascular pharmacology 1997;29(4):451-6.
1997: Charles R H Wildevuur; Piet G M Jansen; P Dick Bezemer; Dirk J Kuik; León Eijsman; Peter Bruins; A P De Jong; F W Van Hardevelt; J D Biervliet; J Michael Hasenkam; Hans Henrik O Kure; Lars Knudsen; L Bellaiche; P Ahlburg; Daniel Loisance; Christophe Baufreton; Paul Le Besnerais; G Bajan; A Matta; M Van Dyck; M T Renotte; A Ponlot-Lois; Philippe Baele; E A McGovern; E Ahlvin
Clinical evaluation of Duraflo II heparin treated extracorporeal circulation circuits (2nd version). The European Working Group on heparin coated extracorporeal circulation circuits.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 1997;11(4):616-23; discussion 624-5.
1996: Heleen Oudemans-van Straaten; Piet G M Jansen; H Velthuis; C P Stoutenbeek; Durk F Zandstra; S J Deventer; Augueste Sturk; Charles R H Wildevuur; León Eijsman
Endotoxaemia and postoperative hypermetabolism in coronary artery bypass surgery: the role of ketanserin.
British journal of anaesthesia 1996;77(4):473-9.
1996: M B Vroom; Harry B van Wezel; R B vd Brink; R vd Lee; León Eijsman; Cees A Visser; Pieter A van Zwieten
Effects of dobutamine and enoximone on transmitral and pulmonary venous flow characteristics in patients with left ventricular dysfunction after coronary artery bypass grafting.
Journal of cardiothoracic and vascular anesthesia 1996;10(6):756-63.
1996: Henk te Velthuis; Piet G M Jansen; C Erik Hack; León Eijsman; Charles R H Wildevuur
Specific complement inhibition with heparin-coated extracorporeal circuits.
The Annals of thoracic surgery 1996;61(4):1153-7.
1996: Henk te Velthuis; Piet G M Jansen; Heleen Oudemans-van Straaten; Gerard J van Kamp; Augueste Sturk; León Eijsman; Charles R H Wildevuur
Circulating endothelin in cardiac operations: influence of blood pressure and endotoxin.
The Annals of thoracic surgery 1996;61(3):904-8.
1996: R C Rotteveel; K J Roozendaal; Rob N M Weijers; León Eijsman
Influence of heparin, protamine and polybrene on the time integral of thrombin generation (endogenous thrombin potential).
Haemostasis 1996;26(1):1-10.
1996: Piet G M Jansen; Henk te Velthuis; W R Wildevuur; M A J M Huybregts; E R Bulder; H I van der Spoel; Augueste Sturk; León Eijsman; Charles R H Wildevuur
Cardiopulmonary bypass with modified fluid gelatin and heparin-coated circuits.
British journal of anaesthesia 1996;76(1):13-9.
1995: Henk te Velthuis; Piet G M Jansen; Heleen Oudemans-van Straaten; Augueste Sturk; León Eijsman; Charles R H Wildevuur
Myocardial performance in elderly patients after cardiopulmonary bypass is suppressed by tumor necrosis factor.
The Journal of thoracic and cardiovascular surgery 1995;110(6):1663-9.
1995: Piet G M Jansen; Henk te Velthuis; E R Bulder; R Paulus; M R Scheltinga; León Eijsman; Charles R H Wildevuur
Reduction in prime volume attenuates the hyperdynamic response after cardiopulmonary bypass.
The Annals of thoracic surgery 1995;60(3):544-9; discussion 549-50.
1995: Piet G M Jansen; Henk te Velthuis; R A Huybregts; R Paulus; E R Bulder; H I van der Spoel; P D Bezemer; E H Slaats; León Eijsman; Charles R H Wildevuur
Reduced complement activation and improved postoperative performance after cardiopulmonary bypass with heparin-coated circuits.
The Journal of thoracic and cardiovascular surgery 1995;110(3):829-34.
1995: N Tabuchi; R C Huet; A Sturk; León Eijsman; Charles R H Wildevuur
Hemostatic function of aspirin-treated platelets vulnerable to cardiopulmonary bypass. Altered shear-induced pathway.
The Journal of thoracic and cardiovascular surgery 1995;110(3):813-8.
1995: M B Vroom; Harry B van Wezel; Cees A Visser; León Eijsman; Pieter A van Zwieten
Hemodynamic effects of the novel selective cAMP-phosphodiesterase III inhibitor R 80122 in anesthetized patients with moderate left ventricular dysfunction before coronary artery bypass grafting.
Journal of cardiothoracic and vascular anesthesia 1995;9(3):272-7.
1995: C G Olthof; Piet G M Jansen; J P de Vries; P M Kouw; León Eijsman; Jaap J de Lange; P M J M de Vries
Interstitial fluid volume during cardiac surgery measured by means of a non-invasive conductivity technique.
Acta anaesthesiologica Scandinavica 1995;39(4):508-12.
1994: N Tabuchi; R C Huet; A Sturk; León Eijsman; Charles R H Wildevuur
Aprotinin preserves hemostasis in aspirin-treated patients undergoing cardiopulmonary bypass.
The Annals of thoracic surgery 1994;58(4):1036-9.
1994: Piet G M Jansen; Henk te Velthuis; Heleen Oudemans-van Straaten; E R Bulder; S J Van Deventer; A Sturk; León Eijsman; Charles R H Wildevuur
Perfusion-related factors of endotoxin release during cardiopulmonary bypass.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 1994;8(3):125-9.
1993: R C Rotteveel; K J Roozendaal; León Eijsman; Coenraad Hemker
The influence of oral contraceptives on the time-integral of thrombin generation (thrombin potential).
Thrombosis and haemostasis 1993;70(6):959-62.
1993: C G Olthof; Piet G M Jansen; E R Bulder; León Eijsman; Jaap J de Lange; P M J M de Vries
Brain swelling after coronary surgery.
Lancet 1993;342(8879):1115.
1992: N J Jansen; Wim van Oeveren; Y John Gu; M H van Vliet; León Eijsman; Charles R H Wildevuur
Endotoxin release and tumor necrosis factor formation during cardiopulmonary bypass.
The Annals of thoracic surgery 1992;54(4):744-7; discussion 747-8.
1991: M P Harder; León Eijsman; K J Roozendaal; Wim van Oeveren; Charles R H Wildevuur
Aprotinin reduces intraoperative and postoperative blood loss in membrane oxygenator cardiopulmonary bypass.
The Annals of thoracic surgery 1991;51(6):936-41.
1990: A A de Smet; M C Joen; Wim van Oeveren; K J Roozendaal; M P Harder; León Eijsman; Charles R H Wildevuur
Increased anticoagulation during cardiopulmonary bypass by aprotinin.
The Journal of thoracic and cardiovascular surgery 1990;100(4):520-7.
1990: Wim van Oeveren; M P Harder; K J Roozendaal; León Eijsman; Charles R H Wildevuur
Aprotinin protects platelets against the initial effect of cardiopulmonary bypass.
The Journal of thoracic and cardiovascular surgery 1990;99(5):788-96; discussion 796-7.
1989: Charles R H Wildevuur; León Eijsman; K J Roozendaal; M P Harder; M Chang; Wim van Oeveren
Platelet preservation during cardiopulmonary bypass with aprotinin.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 1989;3(6):533-7; discussion 537-8.
1988: Wim van Oeveren; León Eijsman; K J Roozendaal; Charles R H Wildevuur
Platelet preservation by aprotinin during cardiopulmonary bypass.
Lancet 1988;1(8586):644.