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Herman Eisen

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Herman N Eisen; Arup K Chakraborty
Immunopaleontology reveals how affinity enhancement is achieved during affinity maturation of antibodies to influenza virus.
Herman N Eisen; Xun Helen Hou; Katerina Kozyrytska; Carol A McKinley; Lakshmi Nambiar; Chase Shen; Crysela Smith; Varsha Keelara Tanguturi; Kaidi Wang; Jianzhu Chen; Richard J Cohen
Promiscuous binding of extracellular peptides to cell surface class I MHC protein.
Herman N Eisen; Arup K Chakraborty
Evolving concepts of specificity in immune reactions.

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2013: Herman N Eisen; Arup K Chakraborty
Immunopaleontology reveals how affinity enhancement is achieved during affinity maturation of antibodies to influenza virus.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(1):7-8.
2012: Herman N Eisen; Xun Helen Hou; Katerina Kozyrytska; Carol A McKinley; Lakshmi Nambiar; Chase Shen; Crysela Smith; Varsha Keelara Tanguturi; Kaidi Wang; Jianzhu Chen; Richard J Cohen
Promiscuous binding of extracellular peptides to cell surface class I MHC protein.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(12):4580-5.
2010: Herman N Eisen; Arup K Chakraborty
Evolving concepts of specificity in immune reactions.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(52):22373-80.
2010: Ching-Hung Shen; Oezcan Talay; Vinay S Mahajan; Ilya B Leskov; Herman N Eisen; Jianzhu Chen
Antigen-bearing dendritic cells regulate the diverse pattern of memory CD8 T-cell development in different tissues.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(52):22587-92.
2010: Hugo Mouquet; Johannes F Scheid; Markus J Zoller; Michelle Krogsgaard; Rene G Ott; Shetha Shukair; Maxim N Artyomov; John Pietzsch; Mark Connors; Florencia Pereyra; Bruce D Walker; David D Ho; Patrick C Wilson; Michael S Seaman; Herman N Eisen; Arup K Chakraborty; Thomas J Hope; Jeffrey V Ravetch; Hedda Wardemann; Michel C Nussenzweig
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation.
Nature 2010;467(7315):591-5.
2009: Adam S Chervin; Jennifer D Stone; Phillip D Holler; Ailin Bai; Jianzhu Chen; Herman N Eisen; David M Kranz
The impact of TCR-binding properties and antigen presentation format on T cell responsiveness.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):1166-78.
2008: Ailin Bai; Eileen Higham; Herman N Eisen; K Dane Wittrup; Jianzhu Chen
Rapid tolerization of virus-activated tumor-specific CD8+ T cells in prostate tumors of TRAMP mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):13003-8.
2008: Ching-Hung Shen; Qing Ge; Oezcan Talay; Herman N Eisen; Adolfo García-Sastre; Jianzhu Chen
Loss of IL-7R and IL-15R expression is associated with disappearance of memory T cells in respiratory tract following influenza infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):171-8.
2007: Qibin Leng; Qing Ge; Tam Nguyen; Herman N Eisen; Jianzhu Chen
Stage-dependent reactivity of thymocytes to self-peptide--MHC complexes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5038-43.
2006: Qing Ge; Phillip D Holler; Vinay S Mahajan; Tam Nuygen; Herman N Eisen; Jianzhu Chen
Development of CD4+ T cells expressing a nominally MHC class I-restricted T cell receptor by two different mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1822-7.
2005: Deborah Palliser; Eduardo Guillen; Mindy Ju; Herman N Eisen
Multiple intracellular routes in the cross-presentation of a soluble protein by murine dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):1879-87.
2004: Steven R Little; David M Lynn; Qing Ge; Daniel G Anderson; Sidharth V Puram; Jianzhu Chen; Herman N Eisen; Robert Langer
Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(26):9534-9.
2004: Qing Ge; Lily Filip; Ailin Bai; Tam Nguyen; Herman N Eisen; Jianzhu Chen
Inhibition of influenza virus production in virus-infected mice by RNA interference.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(23):8676-81.
2004: Qing Ge; Herman N Eisen; Jianzhu Chen
Use of siRNAs to prevent and treat influenza virus infection.
Virus research 2004;102(1):37-42.
2004: Qing Ge; Ailin Bai; Brendan Jones; Herman N Eisen; Jianzhu Chen
Competition for self-peptide-MHC complexes and cytokines between naive and memory CD8+ T cells expressing the same or different T cell receptors.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3041-6.
2004: Chun Wang; Qing Ge; David Ting; David Nguyen; Hui-Rong Shen; Jianzhu Chen; Herman N Eisen; Jorge Heller; Robert Langer; David Putnam
Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines.
Nature materials 2004;3(3):190-6.
2004: Markus G Rudolph; Lucy Q Shen; Stephen A Lamontagne; John G Luz; Joseph R Delaney; Qing Ge; Bryan K Cho; Deborah Palliser; Carol A McKinley; Jianzhu Chen; Ian A Wilson; Herman N Eisen
A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):2994-3002.
2004: Deborah Palliser; Qian Huang; Nir Hacohen; Steven P Lamontagne; Eduardo Guillen; Richard A Young; Herman N Eisen
A role for Toll-like receptor 4 in dendritic cell activation and cytolytic CD8+ T cell differentiation in response to a recombinant heat shock fusion protein.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):2885-93.
2003: Qing Ge; Ailin Bai; Ching-Hung Shen; Herman N Eisen; Jianzhu Chen
CD4+ T-cell responses to self-peptide--MHC.
Trends in immunology 2003;24(4):186-9.
2003: Qing Ge; Michael McManus; Tam Nguyen; Ching-Hung Shen; Phillip A Sharp; Herman N Eisen; Jianzhu Chen
RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2718-23.
2003: Jianzhu Chen; Herman N Eisen; David M Kranz
A model T-cell receptor system for studying memory T-cell development.
Microbes and infection / Institut Pasteur 2003;5(3):233-40.
2002: Qing Ge; Jennifer D Stone; M Todd Thompson; Jennifer Cochran; Mia M Rushe; Herman N Eisen; Jianzhu Chen; Lawrence J Stern
Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13729-34.
2002: Qing Ge; Hui Hu; Herman N Eisen; Jianzhu Chen
Naïve to memory T-cell differentiation during homeostasis-driven proliferation.
Microbes and infection / Institut Pasteur 2002;4(5):555-8.
2002: Qing Ge; Hui Hu; Herman N Eisen; Jianzhu Chen
Different contributions of thymopoiesis and homeostasis-driven proliferation to the reconstitution of naive and memory T cell compartments.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2989-94.
2002: Qing Ge; Deborah Palliser; Herman N Eisen; Jianzhu Chen
Homeostatic T cell proliferation in a T cell-dendritic cell coculture system.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2983-8.
2002: Satoshi Sugawa; Deborah Palliser; Herman N Eisen; Jianzhu Chen
How do cultured CD8(+) murine T cell clones survive repeated ligation of the TCR?
International immunology 2002;14(1):23-30.
2001: S Kageyama; T J Tsomides; N Fukusen; Ioannis Papayannopoulos; Herman N Eisen; Y Sykulev
Potent cytolytic response by a CD8+ CTL clone to multiple peptides from the same protein in association with an allogeneic class I MHC molecule.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3028-34.
2001: Qing Ge; Varada P Rao; Bryan K Cho; Herman N Eisen; Jianzhu Chen
Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1728-33.
2001: Bryan K Cho; K C Lian; P Lee; A Brunmark; C McKinley; Jianzhu Chen; David M Kranz; Herman N Eisen
Differences in antigen recognition and cytolytic activity of CD8(+) and CD8(-) T cells that express the same antigen-specific receptor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1723-7.
2000: Bryan K Cho; Varada P Rao; Qing Ge; Herman N Eisen; Jianzhu Chen
Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells.
The Journal of experimental medicine 2000;192(4):549-56.
2000: Bryan K Cho; Deborah Palliser; Eduardo Guillen; J Wisniewski; Richard A Young; Jianzhu Chen; Herman N Eisen
A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins.
Immunity 2000;12(3):263-72.
1999: X Zhou; S Wong; J Walter; T Jacks; Herman N Eisen
Increased generation of CD8+ T cell clones in p53 mutant mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(7):3957-60.
1999: Bryan K Cho; C Wang; S Sugawa; Herman N Eisen; Jianzhu Chen
Functional differences between memory and naive CD8 T cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2976-81.
1998: Y Sykulev; Y Vugmeyster; A Brunmark; Hidde L Ploegh; Herman N Eisen
Peptide antagonism and T cell receptor interactions with peptide-MHC complexes.
Immunity 1998;9(4):475-83.
1998: J B Walter; David N Garboczi; QR Fan; X Zhou; Bruce D Walker; Herman N Eisen
A mutant human beta2-microglobulin can be used to generate diverse multimeric class I peptide complexes as specific probes for T cell receptors.
Journal of immunological methods 1998;214(1-2):41-50.
1998: J R Delaney; Y Sykulev; Herman N Eisen; Susumu Tonegawa
Differences in the level of expression of class I major histocompatibility complex proteins on thymic epithelial and dendritic cells influence the decision of immature thymocytes between positive and negative selection.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):5235-40.
1997: J B Walter; C Brander; M Mammen; David N Garboczi; S A Kalams; G M Whitesides; Bruce D Walker; Herman N Eisen
Stimulation of human cytotoxic T cells with HIV-1-derived peptides presented by recombinant HLA-A2 peptide complexes.
International immunology 1997;9(3):451-9.
1997: T J Tsomides; E B Reilly; Herman N Eisen
Anti-melanoma cytotoxic T lymphocytes (CTL) recognize numerous antigenic peptides having 'self' sequences: autoimmune nature of the anti-melanoma CTL response.
International immunology 1997;9(2):327-38.
1996: Y Sykulev; M Joo; I Vturina; T J Tsomides; Herman N Eisen
Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response.
Immunity 1996;4(6):565-71.
1996: Herman N Eisen; Y Sykulev; T J Tsomides
Antigen-specific T-cell receptors and their reactions with complexes formed by peptides with major histocompatibility complex proteins.
Advances in protein chemistry 1996;49():1-56.
1995: Y Sykulev; R J Cohen; Herman N Eisen
The law of mass action governs antigen-stimulated cytolytic activity of CD8+ cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):11990-2.
1995: M X Wu; T J Tsomides; Herman N Eisen
Tissue distribution of natural peptides derived from a ubiquitous dehydrogenase, including a novel liver-specific peptide that demonstrates the pronounced specificity of low affinity T cell reactions.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(9):4495-502.
1995: S Kageyama; T J Tsomides; Y Sykulev; Herman N Eisen
Variations in the number of peptide-MHC class I complexes required to activate cytotoxic T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(2):567-76.
1994: Y Sykulev; A Brunmark; T J Tsomides; S Kageyama; M Jackson; P A Peterson; Herman N Eisen
High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11487-91.
1994: T J Tsomides; A Aldovini; R P Johnson; Bruce D Walker; Richard A Young; Herman N Eisen
Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1.
The Journal of experimental medicine 1994;180(4):1283-93.
1994: J P Dutz; T J Tsomides; S Kageyama; M H Rasmussen; Herman N Eisen
A cytotoxic T lymphocyte clone can recognize the same naturally occurring self peptide in association with a self and nonself class I MHC protein.
Molecular immunology 1994;31(13):967-75.
1994: T J Tsomides; Herman N Eisen
T-cell antigens in cancer.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3487-9.
1994: Y Sykulev; A Brunmark; M Jackson; R J Cohen; P A Peterson; Herman N Eisen
Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes.
Immunity 1994;1(1):15-22.
1993: K Udaka; T J Tsomides; Peter Walden; N Fukusen; Herman N Eisen
A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):11272-6.
1993: Herman N Eisen; T Tsomides; K Udaka; Peter Walden; N Fukusen
Incorrect attribution of peptide source.
Cell 1993;75(4):613.
1993: M W Su; Peter Walden; D B Golan; Herman N Eisen
Cognate peptide-induced destruction of CD8+ cytotoxic T lymphocytes is due to fratricide.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(2):658-67.
1993: T J Tsomides; Herman N Eisen
Stoichiometric labeling of peptides by iodination on tyrosyl or histidyl residues.
Analytical biochemistry 1993;210(1):129-35.
1993: Y K Sykulev; R J Cohen; Herman N Eisen
Particle counting by flow cytometry can determine intrinsic equilibrium constants for antibody-ligand interactions in solution.
Molecular immunology 1993;30(1):101-4.
1993: T J Tsomides; Herman N Eisen
Identification of naturally occurring peptides associated with MHC molecules.
Chemical immunology 1993;57():166-96.
1992: K Udaka; T J Tsomides; Herman N Eisen
A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein.
Cell 1992;69(6):989-98.
1992: Y K Sykulev; D A Sherman; R J Cohen; Herman N Eisen
Quantitation of reversible binding by particle counting: hapten-antibody interaction as a model system.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4703-7.
1992: J P Dutz; Peter Walden; Herman N Eisen
Effects of cognate peptides on cytolytic and proliferative activities of cloned cytotoxic T lymphocytes.
International immunology 1992;4(5):571-80.
1991: T J Tsomides; Bruce D Walker; Herman N Eisen
An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11276-80.
1991: T J Tsomides; Herman N Eisen
Antigenic structures recognized by cytotoxic T lymphocytes.
The Journal of biological chemistry 1991;266(6):3357-60.
1990: Peter Walden; Herman N Eisen
Cognate peptides induce self-destruction of CD8+ cytolytic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):9015-9.
1990: T J Elliott; Herman N Eisen
Cytotoxic T lymphocytes recognize a reconstituted class I histocompatibility antigen (HLA-A2) as an allogeneic target molecule.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(13):5213-7.
1990: C Nagler-Anderson; Herman N Eisen
Resistance of normal, unstimulated, CD8+ T cells to lysis by cytotoxic granules from cloned T cell lines.
International immunology 1990;2(1):99-103.
1989: C Nagler-Anderson; Mathias G Lichtenheld; Herman N Eisen; Eckhard R Podack
Perforin mRNA in primary peritoneal exudate cytotoxic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3440-3.
1988: N L Allbritton; C Nagler-Anderson; T J Elliott; C R Verret; Herman N Eisen
Target cell lysis by cytotoxic T lymphocytes that lack detectable hemolytic perforin activity.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(10):3243-8.
1988: C Nagler-Anderson; C R Verret; A A Firmenich; M Berne; Herman N Eisen
Resistance of primary CD8+ cytotoxic T lymphocytes to lysis by cytotoxic granules from cloned T cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(10):3299-305.
1988: T J Elliott; Herman N Eisen
Allorecognition of purified major histocompatibility complex glycoproteins by cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(8):2728-32.
1988: C Nagler-Anderson; N L Allbritton; C R Verret; Herman N Eisen
A comparison of the cytolytic properties of murine primary CD8+ cytotoxic T lymphocytes and cloned cytotoxic T cell lines.
Immunological reviews 1988;103():111-25.
1988: William Shay Ferguson; C R Verret; E B Reilly; M J Iannini; Herman N Eisen
Serine esterase and hemolytic activity in human cloned cytotoxic T lymphocytes.
The Journal of experimental medicine 1988;167(2):528-40.
1988: N L Allbritton; C R Verret; R C Wolley; Herman N Eisen
Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes.
The Journal of experimental medicine 1988;167(2):514-27.
1988: M A Liu; S R Nussbaum; Herman N Eisen
Hormone conjugated with antibody to CD3 mediates cytotoxic T cell lysis of human melanoma cells.
Science (New York, N.Y.) 1988;239(4838):395-8.
1987: C R Verret; A A Firmenich; David M Kranz; Herman N Eisen
Resistance of cytotoxic T lymphocytes to the lytic effects of their toxic granules.
The Journal of experimental medicine 1987;166(5):1536-47.
1987: Herman N Eisen; C R Verret; A A Firmenich; David M Kranz
Resistance of cytolytic T lymphocytes to the lytic components they release.
Annales de l'Institut Pasteur. Immunology 1987;138(2):328-31.
1986: J Lieberman; C R Verret; David M Kranz; S C Hubbard; H Saito; D H Raulet; Susumu Tonegawa; Herman N Eisen
A phosphorylated, disulfide-linked membrane protein in murine cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(20):7870-4.
1986: M S Pasternack; C R Verret; M A Liu; Herman N Eisen
Serine esterase in cytolytic T lymphocytes.
Nature 1986;322(6081):740-3.
1986: S C Hubbard; David M Kranz; G D Longmore; M V Sitkovsky; Herman N Eisen
Glycosylation of the T-cell antigen-specific receptor and its potential role in lectin-mediated cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(6):1852-6.
1984: D H Sherman; David M Kranz; Herman N Eisen
Expression of structurally diverse Qa-2-encoded molecules on the surface of cloned cytotoxic T lymphocytes.
The Journal of experimental medicine 1984;160(5):1421-30.
1984: M V Sitkovsky; M S Pasternack; J P Lugo; J R Klein; Herman N Eisen
Isolation and partial characterization of concanavalin A receptors on cloned cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(5):1519-23.
1984: David M Kranz; D H Sherman; M V Sitkovsky; M S Pasternack; Herman N Eisen
Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(2):573-7.
1983: M S Pasternack; M V Sitkovsky; Herman N Eisen
The site of action of N-alpha-tosyl-L-lysyl-chloromethyl-ketone (TLCK) on cloned cytotoxic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1983;131(5):2477-83.
1982: M V Sitkovsky; M S Pasternack; Herman N Eisen
Inhibition of cytotoxic T lymphocyte activity by concanavalin A.
Journal of immunology (Baltimore, Md. : 1950) 1982;129(4):1372-6.