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Decio Eizirik

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Decio L Eizirik; M Miani; Alessandra K Cardozo
Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation.
Hannelie Korf; Decio L Eizirik; Conny Gysemans; Michela Miani; Sofie Robert; Benoit Stijlemans; Tatiana Takiishi; Mathias Wenes; Chantal Mathieu
1,25-Dihydroxyvitamin D3 curtails the inflammatory and T cell stimulatory capacity of macrophages through an IL-10-dependent mechanism.
Decio L Eizirik; Miriam Cnop
Mining genes in type 2 diabetic islets and finding gold.

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All Publications

2013: Decio L Eizirik; M Miani; Alessandra K Cardozo
Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation.
Diabetologia 2013;56(2):234-41.
2012: Hannelie Korf; Decio L Eizirik; Conny Gysemans; Michela Miani; Sofie Robert; Benoit Stijlemans; Tatiana Takiishi; Mathias Wenes; Chantal Mathieu
1,25-Dihydroxyvitamin D3 curtails the inflammatory and T cell stimulatory capacity of macrophages through an IL-10-dependent mechanism.
Immunobiology 2012;217(12):1292-300.
2012: Decio L Eizirik; Miriam Cnop
Mining genes in type 2 diabetic islets and finding gold.
Cell metabolism 2012;16(5):555-7.
2012: Florent Allagnat; D Delaroche; Decio L Eizirik; M Fukaya; J A Haefliger; P Marchetti; Lorella Marselli; T C Nogueira; N Welsh; Alessandra K Cardozo
C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells.
Cell death and differentiation 2012;19(11):1836-46.
2012: I Marhfour; N G Morgan; S J Richardson; Isabelle Salmon; Florent Allagnat; D Lefkaditis; X M Lopez; Decio L Eizirik
Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes.
Diabetologia 2012;55(9):2417-20.
2012: Decio L Eizirik; Fabio A Grieco
On the immense variety and complexity of circumstances conditioning pancreatic β-cell apoptosis in type 1 diabetes.
Diabetes 2012;61(7):1661-3.
2012: Michela Miani; Laurence Ladrière; Miriam Cnop; Maikel L Colli; Decio L Eizirik
Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway.
Endocrinology 2012;153(7):3017-28.
2012: Fernanda Ortis; Esteban N Gurzov; M Miani; Florent Allagnat; Alain Chariot; M L Colli; Daniel Cunha; Decio L Eizirik
Differential usage of NF-κB activating signals by IL-1β and TNF-α in pancreatic beta cells.
FEBS letters 2012;586(7):984-9.
2012: M Maris; L Overbergh; E Verdrengh; A Waget; R Burcelin; Alessandra K Cardozo; Miriam Cnop; J P M Cunha; Decio L Eizirik; T Gotoh; Conny Gysemans; Chantal Mathieu
Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance.
Diabetologia 2012;55(4):1167-78.
2012: Esteban N Gurzov; Conny Gysemans; Mariana Igoillo-Esteve; S Kitajima; P Marchetti; I Marhfour; Chantal Mathieu; Najib Naamane; Fernanda Ortis; Erwin F Wagner; Torben F Orntoft; Latifa Bakiri; J Barthson; Decio L Eizirik
Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation.
Oncogene 2012;31(13):1723-32.
2012: Michael Volkmar; Ute Volkmar; Mariana Igoillo-Esteve; Piero Marchetti; Matilde Masini; Najib Naamane; Matladi N Ndlovu; Marco Bugliani; Emilie Calonne; Miriam Cnop; Daniel A Cunha; Sarah Dedeurwaerder; Matthieu Defrance; Silvia Del Guerra; Rachel Deplus; Decio L Eizirik; François Fuks
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients.
The EMBO journal 2012;31(6):1405-26.
2012: Izortze Santin; C Brancolini; F A Grieco; P Marchetti; Fabrice Moore; Decio L Eizirik
USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis.
Cell death & disease 2012;3():e419.
2012: Fabrice Moore; Tatiane C Nogueira; Izortze Santin; Esteban N Gurzov; Piero Marchetti; Lorella Marselli; Decio L Eizirik
The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells.
PloS one 2012;7(2):e31062.
2012: Fabrice Moore; Hindrik Mulder; Daniel A Cunha; Decio L Eizirik
Use of RNA interference to investigate cytokine signal transduction in pancreatic beta cells.
Methods in molecular biology (Clifton, N.J.) 2012;820():179-94.
2011: Izortze Santin; Maikel L Colli; Esteban N Gurzov; Piero Marchetti; Lorella Marselli; Fabrice Moore; Decio L Eizirik
PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.
Diabetes 2011;60(12):3279-88.
2011: Jenny Barthson; Daniel J Drucker; Decio L Eizirik; Carla M Germano; Conny Gysemans; Andrea Jurisicova; Adriano Maida; Piero Marchetti; Chantal Mathieu; Fabrice Moore; Gabriel Nuñez; Esteban N Gurzov
Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation.
The Journal of biological chemistry 2011;286(45):39632-43.
2011: Maikel L Colli; Daniel Cunha; Florent Allagnat; Alessandra K Cardozo; Esteban N Gurzov; Tatiane C Nogueira; A Op De Beeck; Merja Roivainen; Decio L Eizirik
Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.
PLoS pathogens 2011;7(9):e1002267.
2011: Sefina Arif; Thomas Bouckenooghe; Colin M Dayan; Decio L Eizirik; Esteban N Gurzov; Guo Cai Huang; Piero Marchetti; Katherine Marks; Fabrice Moore; Raquel Planas; Jake Powrie; Ricardo Pujol Borrell; tim tree; Marta Vives-Pi; Mark Peakman
Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death.
Diabetes 2011;60(8):2112-9.
2011: Esteban N Gurzov; Decio L Eizirik
Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction.
Trends in cell biology 2011;21(7):424-31.
2011: Mariana Igoillo-Esteve; Esteban N Gurzov; Decio L Eizirik; Miriam Cnop
The transcription factor B-cell lymphoma (BCL)-6 modulates pancreatic {beta}-cell inflammatory responses.
Endocrinology 2011;152(2):447-56.
2011: Florent Allagnat; Daniel Cunha; F Moore; Jean-Marie Vanderwinden; Decio L Eizirik; Alessandra K Cardozo
Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis.
Cell death and differentiation 2011;18(2):328-37.
2011: Fabrice Moore; Najib Naamane; Maikel L Colli; Thomas Bouckenooghe; Fernanda Ortis; Esteban N Gurzov; Mariana Igoillo-Esteve; Chantal Mathieu; Gianluca Bontempi; Thomas Thykjaer; Torben F Ørntoft; Decio L Eizirik
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation.
The Journal of biological chemistry 2011;286(2):929-41.
2010: Wannes D'Hertog; Michael Maris; Gabriela B Ferreira; Eefje Verdrengh; Kasper Lage; Daniel A Hansen; Alessandra K Cardozo; Christopher T Workman; Yves Moreau; Decio L Eizirik; Etienne Waelkens; Lut Overbergh; Chantal Mathieu
Novel insights into the global proteome responses of insulin-producing INS-1E cells to different degrees of endoplasmic reticulum stress.
Journal of proteome research 2010;9(10):5142-52.
2010: Daisy Flamez; Isabelle Roland; A Berton; Burak Kutlu; D Dufrane; M C Beckers; E De Waele; Ilse Rooman; Luc Bouwens; A Clark; M Lonneux; J F Jamar; Serge Goldman; D Maréchal; N Goodman; P Gianello; Christophe Henri Van Huffel; Isabelle Salmon; Decio L Eizirik
A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)gammaa as a pancreatic beta cell-specific biomarker.
Diabetologia 2010;53(7):1372-83.
2010: Mariana Igoillo-Esteve; L Marselli; Daniel Cunha; Laurence Ladrière; Fernanda Ortis; F A Grieco; F Dotta; G C Weir; P Marchetti; Decio L Eizirik; Miriam Cnop
Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes.
Diabetologia 2010;53(7):1395-405.
2010: Esteban N Gurzov; Carla M Germano; Daniel Cunha; Fernanda Ortis; Jean-Marie Vanderwinden; Piero Marchetti; Lin Zhang; Decio L Eizirik
p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress.
The Journal of biological chemistry 2010;285(26):19910-20.
2010: F Allagnat; F Christulia; Fernanda Ortis; Pierre Pirot; S Lortz; Sigurd Lenzen; Decio L Eizirik; Alessandra K Cardozo
Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis.
Diabetologia 2010;53(6):1120-30.
2010: Thomas Bouckenooghe; Daisy Flamez; Fernanda Ortis; Serge Goldman; Decio L Eizirik
Identification of new pancreatic beta cell targets for in vivo imaging by a systems biology approach.
Current pharmaceutical design 2010;16(14):1609-18.
2010: Fernanda Ortis; Najib Naamane; Daisy Flamez; Laurence Ladrière; Fabrice Moore; Daniel Cunha; Maikel L Colli; Thomas Thykjaer; Kasper Thorsen; Torben F Orntoft; Decio L Eizirik
Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells.
Diabetes 2010;59(2):358-74.
2010: Robin Liechti; Gábor Csárdi; Sven Bergmann; Frédéric Schütz; Thierry Sengstag; Sylvia F Boj; Joan-Marc Servitja; Jorge Ferrer; Leentje Van Lommel; Frans Schuit; Sonia Klinger; Bernard Thorens; Najib Naamane; Decio L Eizirik; Lorella Marselli; Marco Bugliani; Piero Marchetti; Stephanie Lucas; Cecilia Holm; C Victor Jongeneel; Ioannis Xenarios
EuroDia: a beta-cell gene expression resource.
Database : the journal of biological databases and curation 2010;2010():baq024.
2010: Decio L Eizirik; Miriam Cnop
ER stress in pancreatic beta cells: the thin red line between adaptation and failure.
Science signaling 2010;3(110):pe7.
2010: Maikel L Colli; Fabrice Moore; Esteban N Gurzov; Fernanda Ortis; Decio L Eizirik
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA.
Human molecular genetics 2010;19(1):135-46.
2009: Mónica García; Zeynep Dogusan; Fabrice Moore; Shintaro Sato; Gunther Hartmann; Decio L Eizirik; Joanne Rasschaert
Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells.
Biochimica et biophysica acta 2009;1793(11):1768-75.
2009: Esteban N Gurzov; Fernanda Ortis; Daniel Cunha; G Gosset; M Li; Alessandra K Cardozo; Decio L Eizirik
Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis.
Cell death and differentiation 2009;16(11):1539-50.
2009: Ning Li; Thierry Brun; Miriam Cnop; Daniel Cunha; Decio L Eizirik; Pierre Maechler
Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction.
The Journal of biological chemistry 2009;284(35):23602-12.
2009: Fabrice Moore; Maikel L Colli; Miriam Cnop; Mariana Igoillo-Esteve; Alessandra K Cardozo; Daniel Cunha; Marco Bugliani; Piero Marchetti; Decio L Eizirik
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.
Diabetes 2009;58(6):1283-91.
2009: Decio L Eizirik
Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes: response to Nathan et al.
Diabetes care 2009;32(3):e35-6; author reply e37-8.
2009: Burak Kutlu; David Burdick; David Baxter; Joanne Rasschaert; Daisy Flamez; Decio L Eizirik; Nils Welsh; Nathan Goodman; Leroy Hood
Detailed transcriptome atlas of the pancreatic beta cell.
BMC medical genomics 2009;2():3.
2008: Miriam Cnop; Mariana Igoillo-Esteve; Daniel Cunha; Laurence Ladrière; Decio L Eizirik
An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells.
Biochemical Society transactions 2008;36(Pt 5):909-15.
2008: Daniel Cunha; Paul Hekerman; Laurence Ladrière; Angie Bazarra-Castro; Fernanda Ortis; Marion C Wakeham; Fabrice Moore; Joanne Rasschaert; Alessandra K Cardozo; Elisa Bellomo; Lutgart Overbergh; Chantal Mathieu; Roberto Lupi; Tsonwin Hai; Andre Herchuelz; Piero Marchetti; Guy Rutter; Decio L Eizirik; Miriam Cnop
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.
Journal of cell science 2008;121(Pt 14):2308-18.
2008: Fernanda Ortis; Pierre Pirot; Najib Naamane; A Y Kreins; Joanne Rasschaert; Fabrice Moore; E Théâtre; C Verhaeghe; Nils E Magnusson; Alain Chariot; Torben F Orntoft; Decio L Eizirik
Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.
Diabetologia 2008;51(7):1213-25.
2008: Decio L Eizirik; Fabrice Moore; Daisy Flamez; Fernanda Ortis
Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes.
Biochemical Society transactions 2008;36(Pt 3):321-7.
2008: Zeynep Dogusan; Mónica García; Daisy Flamez; Lena Alexopoulou; Michel Goldman; Conny Gysemans; Chantal Mathieu; Claude Libert; Decio L Eizirik; Joanne Rasschaert
Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways.
Diabetes 2008;57(5):1236-45.
2008: Amir J Guri; Raquel Hontecillas; Gerardo Ferrer; Oriol Casagran; Umesh Wankhade; Alexis M Noble; Decio L Eizirik; Fernanda Ortis; Miriam Cnop; Dongmin Liu; Hongwei Si; Josep Bassaganya-Riera
Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue.
The Journal of nutritional biochemistry 2008;19(4):216-28.
2008: Pierre Pirot; Alessandra K Cardozo; Decio L Eizirik
Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes.
Arquivos brasileiros de endocrinologia e metabologia 2008;52(2):156-65.
2008: Decio L Eizirik; Alessandra K Cardozo; Miriam Cnop
The role for endoplasmic reticulum stress in diabetes mellitus.
Endocrine reviews 2008;29(1):42-61.
2008: Esteban N Gurzov; Fernanda Ortis; Latifa Bakiri; Erwin F Wagner; Decio L Eizirik
JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells.
PloS one 2008;3(8):e3030.
2007: Wannes D'Hertog; Lut Overbergh; Kasper Lage; Gabriela Bonfim Ferreira; Michael Maris; Conny Gysemans; Daisy Flamez; Alessandra Kupper Cardozo; Gert Van den Bergh; Liliane Schoofs; Lutgarde Arckens; Yves Moreau; Daniel Aaen Hansen; Decio L Eizirik; Ettienne Waelkens; Chantal Mathieu
Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved.
Molecular & cellular proteomics : MCP 2007;6(12):2180-99.
2007: Piero Marchetti; Marco Bugliani; ROBERTO LUPI; Lorella Marselli; Matilde Masini; Ugo Boggi; Franco Filipponi; G C Weir; Decio L Eizirik; Miriam Cnop
The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.
Diabetologia 2007;50(12):2486-94.
2007: Alessandra K Cardozo; Valérie Buchillier; Marc Mathieu; Jianhua Chen; Fernanda Ortis; Laurence Ladrière; Nathalie Allaman-Pillet; Olivier Poirot; Stephan Kellenberger; Jacques Beckmann; Decio L Eizirik; Christophe Bonny; Fabienne Maurer
Cell-permeable peptides induce dose- and length-dependent cytotoxic effects.
Biochimica et biophysica acta 2007;1768(9):2222-34.
2007: Hanne Callewaert; Conny Gysemans; Laurence Ladrière; Wannes D'Hertog; Julianna Hagenbrock; Lut Overbergh; Decio L Eizirik; Chantal Mathieu
Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection.
Diabetes 2007;56(8):2169-73.
2007: Pierre Pirot; Najib Naamane; F Libert; Nils E Magnusson; Torben F Ørntoft; Alessandra K Cardozo; Decio L Eizirik
Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs.
Diabetologia 2007;50(5):1006-14.
2007: Pierre Pirot; Fernanda Ortis; Miriam Cnop; Yanjun Ma; Linda M Hendershot; Decio L Eizirik; Alessandra K Cardozo
Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells.
Diabetes 2007;56(4):1069-77.
2007: Miriam Cnop; Laurence Ladriere; Paul Hekerman; Fernanda Ortis; Alessandra K Cardozo; Zeynep Dogusan; Daisy Flamez; Michael Boyce; Junying Yuan; Decio L Eizirik
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.
The Journal of biological chemistry 2007;282(6):3989-97.
2007: Hanne Callewaert; Conny Gysemans; Alessandra K Cardozo; Matthias Elsner; Markus Tiedge; Decio L Eizirik; Chantal Mathieu
Cell loss during pseudoislet formation hampers profound improvements in islet lentiviral transduction efficacy for transplantation purposes.
Cell transplantation 2007;16(5):527-37.
2007: Najib Naamane; Jacques van Helden; Decio L Eizirik
In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells.
BMC bioinformatics 2007;8():55.
2007: Erin M Hulbert; Luc J Smink; Ellen C Adlem; James E Allen; David B Burdick; Oliver Burren; Victor M Cassen; Christopher C Cavnor; Geoffrey E Dolman; Daisy Flamez; Karen F Friery; Barry C Healy; Sarah A Killcoyne; Burak Kutlu; Helen Schuilenburg; Neil M Walker; Josyf C Mychaleckyj; Decio L Eizirik; Linda S Wicker; John A Todd; Nathan Goodman
T1DBase: integration and presentation of complex data for type 1 diabetes research.
Nucleic acids research 2007;35(Database issue):D742-6.
2006: Ilham Kharroubi; C-H Lee; Paul Hekerman; Martine I Darville; R M Evans; Decio L Eizirik; Miriam Cnop
BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells.
Diabetologia 2006;49(10):2350-8.
2006: Fernanda Ortis; Alessandra K Cardozo; Daisy Crispim; Joachim Störling; Thomas Mandrup-Poulsen; Decio L Eizirik
Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.
Molecular endocrinology (Baltimore, Md.) 2006;20(8):1867-79.
2006: Pierre Pirot; Decio L Eizirik; Alessandra K Cardozo
Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms.
Diabetologia 2006;49(6):1229-36.
2006: Martine I Darville; Decio L Eizirik
Notch signaling: a mediator of beta-cell de-differentiation in diabetes?
Biochemical and biophysical research communications 2006;339(4):1063-8.
2005: Dehuang Guo; Junyan Han; Bao-Ling Adam; Nancy H Colburn; Mong-Heng Wang; Zheng Dong; Decio L Eizirik; Jin-Xiong She; Cong-Yi Wang
Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.
Biochemical and biophysical research communications 2005;337(4):1308-18.
2005: Miriam Cnop; Nils Welsh; Jean-Christophe Jonas; Anne Jörns; Sigurd Lenzen; Decio L Eizirik
Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.
Diabetes 2005;54 Suppl 2():S97-107.
2005: L Larsen; Joachim Størling; Martine I Darville; Decio L Eizirik; Christophe Bonny; Nils Billestrup; Thomas Mandrup-Poulsen
Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells.
Diabetologia 2005;48(12):2582-90.
2005: Nils Welsh; Miriam Cnop; Ilham Kharroubi; Marco Bugliani; ROBERTO LUPI; Piero Marchetti; Decio L Eizirik
Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?
Diabetes 2005;54(11):3238-44.
2005: Joanne Rasschaert; Laurence Ladrière; Maryse Urbain; Zeynep Dogusan; Bitty Katabua; Shintaro Sato; Shizuo Akira; Conny Gysemans; Chantal Mathieu; Decio L Eizirik
Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells.
The Journal of biological chemistry 2005;280(40):33984-91.
2005: Conny Gysemans; Laurence Ladrière; Hanne Callewaert; Joanne Rasschaert; Daisy Flamez; David E Levy; Patrick Matthys; Decio L Eizirik; Chantal Mathieu
Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.
Diabetes 2005;54(8):2396-403.
2005: Petri Ylipaasto; Burak Kutlu; Suvi Rasilainen; Joanne Rasschaert; K Salmela; H Teerijoki; Olle Korsgren; R Lahesmaa; Tapani Hovi; Decio L Eizirik; Timo Otonkoski; Merja Roivainen
Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets.
Diabetologia 2005;48(8):1510-22.
2005: Manyu Li; Dehuang Guo; Carlos M. Isales; Decio L Eizirik; Mark Atkinson; Jin-Xiong She; Cong-Yi Wang
SUMO wrestling with type 1 diabetes.
Journal of molecular medicine (Berlin, Germany) 2005;83(7):504-13.
2005: Conny Gysemans; Alessandra K Cardozo; Hanne Callewaert; Annapaula Giulietti; Leen Hulshagen; Roger Bouillon; Decio L Eizirik; Chantal Mathieu
1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice.
Endocrinology 2005;146(4):1956-64.
2005: Alessandra K Cardozo; Fernanda Ortis; Joachim Storling; Ying-Mei Feng; Joanne Rasschaert; Morten Tonnesen; Françoise Van Eylen; Thomas Mandrup-Poulsen; André Herchuelz; Decio L Eizirik
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.
Diabetes 2005;54(2):452-61.
2005: Nils E Magnusson; Alessandra K Cardozo; Mogens Kruhøffer; Decio L Eizirik; Torben F Ørntoft; Jens Ledet Jensen
Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis.
BMC bioinformatics 2005;6():311.
2005: Luc J Smink; Erin M Helton; Barry C Healy; Christopher C Cavnor; Alex C Lam; Daisy Flamez; Oliver Burren; Yang Wang; Geoffrey E Dolman; David B Burdick; Vincent H Everett; Gustavo Glusman; Davide Laneri; Lee Rowen; Helen Schuilenburg; Neil M Walker; Josyf C Mychaleckyj; Linda S Wicker; Decio L Eizirik; John A Todd; Nathan Goodman
T1DBase, a community web-based resource for type 1 diabetes research.
Nucleic acids research 2005;33(Database issue):D544-9.
2004: Burak Kutlu; Najib Naamane; Laurence Berthou; Decio L Eizirik
New approaches for in silico identification of cytokine-modified beta cell gene networks.
Annals of the New York Academy of Sciences 2004;1037():41-58.
2004: Allan E Karlsen; Peter E Heding; H Frobøse; Sif G Rønn; Mogens Kruhøffer; T F Orntoft; Martine I Darville; Decio L Eizirik; Flemming Pociot; Jørn Nerup; Thomas Mandrup-Poulsen; Nils Billestrup
Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.
Diabetologia 2004;47(11):1998-2011.
2004: Ilham Kharroubi; Laurence Ladrière; Alessandra K Cardozo; Zeynep Dogusan; Miriam Cnop; Decio L Eizirik
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.
Endocrinology 2004;145(11):5087-96.
2004: Mark de Ridder; Valeri N Verovski; Martine I Darville; Dirk L Van den Berge; Christinne Monsaert; Decio L Eizirik; Guy Storme
Macrophages enhance the radiosensitizing activity of lipid A: a novel role for immune cells in tumor cell radioresponse.
International journal of radiation oncology, biology, physics 2004;60(2):598-606.
2004: Mica Ohara-Imaizumi; Alessandra K Cardozo; Toshiteru Kikuta; Decio L Eizirik; Shinya Nagamatsu
The cytokine interleukin-1beta reduces the docking and fusion of insulin granules in pancreatic beta-cells, preferentially decreasing the first phase of exocytosis.
The Journal of biological chemistry 2004;279(40):41271-4.
2004: David Vermijlen; Carine Seynaeve; Dianzhong Luo; Mogens Kruhøffer; Decio L Eizirik; Torben F Ørntoft; Eddie Wisse
High-density oligonucleotide array analysis reveals extensive differences between freshly isolated blood and hepatic natural killer cells.
European journal of immunology 2004;34(9):2529-40.
2004: Martine I Darville; Sara Terryn; Decio L Eizirik
An octamer motif is required for activation of the inducible nitric oxide synthase promoter in pancreatic beta-cells.
Endocrinology 2004;145(3):1130-6.
2003: Ilham Kharroubi; Joanne Rasschaert; Decio L Eizirik; Miriam Cnop
Expression of adiponectin receptors in pancreatic beta cells.
Biochemical and biophysical research communications 2003;312(4):1118-22.
2003: Joanne Rasschaert; D Liu; Burak Kutlu; Alessandra K Cardozo; Mogens Kruhøffer; Torben F Ørntoft; Decio L Eizirik
Global profiling of double stranded RNA- and IFN-gamma-induced genes in rat pancreatic beta cells.
Diabetologia 2003;46(12):1641-57.
2003: Decio L Eizirik; Burak Kutlu; Joanne Rasschaert; Martine I Darville; Alessandra K Cardozo
Use of microarray analysis to unveil transcription factor and gene networks contributing to Beta cell dysfunction and apoptosis.
Annals of the New York Academy of Sciences 2003;1005():55-74.
2003: Burak Kutlu; Alessandra K Cardozo; Martine I Darville; Mogens Kruhøffer; Nils E Magnusson; Torben F Ørntoft; Decio L Eizirik
Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells.
Diabetes 2003;52(11):2701-19.
2003: Alessandra K Cardozo; Laurence Berthou; Mogens Kruhøffer; Torben F Orntoft; Mark R Nicolls; Decio L Eizirik
Gene microarray study corroborates proteomic findings in rodent islet cells.
Journal of proteome research 2003;2(5):553-5.
2003: Alessandra K Cardozo; P Proost; Conny Gysemans; M-C Chen; Chantal Mathieu; Decio L Eizirik
IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice.
Diabetologia 2003;46(2):255-66.
2003: Burak Kutlu; Martine I Darville; Alessandra K Cardozo; Decio L Eizirik
Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells.
Diabetes 2003;52(2):348-55.
2003: Anna Karenina Azevedo-Martins; Stephan Lortz; Sigurd Lenzen; Rui Curi; Decio L Eizirik; Markus Tiedge
Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells.
Diabetes 2003;52(1):93-101.
2002: Dongbo Liu; Alessandra K Cardozo; Martine I Darville; Decio L Eizirik
Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.
Endocrinology 2002;143(4):1225-34.
2002: Karin Vanderkerken; Isabelle Vande Broek; Decio L Eizirik; Els Van Valckenborgh; Kewal Asosingh; Ivan Van Riet; Ben Van Camp
Monocyte chemoattractant protein-1 (MCP-1), secreted by bone marrow endothelial cells, induces chemoattraction of 5T multiple myeloma cells.
Clinical & experimental metastasis 2002;19(1):87-90.
2001: Alessandra K Cardozo; Harry Heimberg; Yves Heremans; R Leeman; Burak Kutlu; Mogens Kruhøffer; T Ørntoft; Decio L Eizirik
A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells.
The Journal of biological chemistry 2001;276(52):48879-86.
2001: Decio L Eizirik; Thomas Mandrup-Poulsen
A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis.
Diabetologia 2001;44(12):2115-33.
2001: Harry Heimberg; Yves Heremans; Christian Jobin; R Leemans; Alessandra K Cardozo; Martine I Darville; Decio L Eizirik
Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis.
Diabetes 2001;50(10):2219-24.
2001: Miriam Cnop; Jean Claude Hannaert; A Hoorens; Decio L Eizirik; Daniel G Pipeleers
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.
Diabetes 2001;50(8):1771-7.
2001: Martine I Darville; Decio L Eizirik
Cytokine induction of Fas gene expression in insulin-producing cells requires the transcription factors NF-kappaB and C/EBP.
Diabetes 2001;50(8):1741-8.
2001: D Liu; Martine I Darville; Decio L Eizirik
Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis.
Endocrinology 2001;142(6):2593-9.
2001: Conny Gysemans; D Pavlovic; Roger Bouillon; Decio L Eizirik; Chantal Mathieu
Dual role of interferon-gamma signalling pathway in sensitivity of pancreatic beta cells to immune destruction.
Diabetologia 2001;44(5):567-74.
2001: Alessandra K Cardozo; Mogens Kruhøffer; R Leeman; Torben F Orntoft; Decio L Eizirik
Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays.
Diabetes 2001;50(5):909-20.
2001: M C Chen; P Proost; Conny Gysemans; C Mathieu; Decio L Eizirik
Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells.
Diabetologia 2001;44(3):325-32.
2001: Martine I Darville; D Liu; M C Chen; Decio L Eizirik
Molecular regulation of Fas expression in beta-cells.
Diabetes 2001;50 Suppl 1():S83.
2001: Decio L Eizirik; Martine I Darville
beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes.
Diabetes 2001;50 Suppl 1():S64-9.
2000: M A Nikulina; HU Andersen; Allan E Karlsen; Martine I Darville; Decio L Eizirik; Thomas Mandrup-Poulsen
Glutathione depletion inhibits IL-1 beta-stimulated nitric oxide production by reducing inducible nitric oxide synthase gene expression.
Cytokine 2000;12(9):1391-4.
2000: M C Chen; V Paez-Espinosa; N Welsh; Decio L Eizirik
Interleukin-1beta regulates phospholipase D-1 expression in rat pancreatic beta-cells.
Endocrinology 2000;141(8):2822-8.
2000: D Liu; D Pavlovic; M C Chen; M Flodström; Stellan Sandler; Decio L Eizirik
Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).
Diabetes 2000;49(7):1116-22.
2000: D Pavlovic; NA Andersen; Thomas Mandrup-Poulsen; Decio L Eizirik
Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic beta-cells.
European cytokine network 2000;11(2):267-74.
2000: T P Hong; NA Andersen; K Nielsen; Allan E Karlsen; Giamila Fantuzzi; Decio L Eizirik; Charles A Dinarello; Thomas Mandrup-Poulsen
Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma.
European cytokine network 2000;11(2):193-205.
2000: Allan E Karlsen; D Pavlovic; K Nielsen; J Jensen; HU Andersen; Flemming Pociot; Thomas Mandrup-Poulsen; Decio L Eizirik; Jørn Nerup
Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism.
The Journal of clinical endocrinology and metabolism 2000;85(2):830-6.
2000: Stellan Sandler; Annika K Andersson; Andreea R Barbu; Claes Hellerström; Maria Holstad; Ella Karlsson; Jan-Olov Sandberg; E Strandell; Johan Saldeen; Johnny Sternesjö; Linda Tillmar; Decio L Eizirik; M Flodström; Nils Welsh
Novel experimental strategies to prevent the development of type 1 diabetes mellitus.
Upsala journal of medical sciences 2000;105(2):17-34.
2000: Merja Roivainen; Suvi Rasilainen; Petri Ylipaasto; R Nissinen; Jarkko Ustinov; Luc Bouwens; Decio L Eizirik; Tapani Hovi; Timo Otonkoski
Mechanisms of coxsackievirus-induced damage to human pancreatic beta-cells.
The Journal of clinical endocrinology and metabolism 2000;85(1):432-40.
2000: A Smismans; Decio L Eizirik; Daniel G Pipeleers
Interleukin-1beta induces ornithine decarboxylase activity in insulin-producing cells.
Cytokine 2000;12(1):49-54.
2000: Martine I Darville; Ye-Shih Ho; Decio L Eizirik
NF-kappaB is required for cytokine-induced manganese superoxide dismutase expression in insulin-producing cells.
Endocrinology 2000;141(1):153-62.
1999: Björn Tyrberg; Decio L Eizirik; Stefan L Marklund; BT Olejnicka; O D Madsen; Arne Andersson
Human islets in mixed islet grafts protect mouse pancreatic beta-cells from alloxan toxicity.
Pharmacology & toxicology 1999;85(6):269-75.
1999: M C Chen; Frans Schuit; Daniel G Pipeleers; Decio L Eizirik
IL-1beta induces serine protease inhibitor 3 (SPI-3) gene expression in rat pancreatic beta-cells. Detection by differential display of messenger RNA.
Cytokine 1999;11(11):856-62.
1999: D Pavlovic; M C Chen; Conny Gysemans; C Mathieu; Decio L Eizirik
The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic beta-cells.
European cytokine network 1999;10(3):403-12.
1999: K Hostens; D Pavlovic; Y Zambre; Zhidong Ling; Chris Van Schravendijk; Decio L Eizirik; Daniel G Pipeleers
Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release.
The Journal of clinical investigation 1999;104(1):67-72.
1999: M Flodström; M C Chen; A Smismans; Frans Schuit; Daniel G Pipeleers; Decio L Eizirik
Interleukin 1beta increases arginine accumulation and activates the citrulline-NO cycle in rat pancreatic beta cells.
Cytokine 1999;11(6):400-7.
1999: Y Zambre; Zhidong Ling; M C Chen; X Hou; C W Woon; M Culler; J E Taylor; D H Coy; Chris Van Schravendijk; Frans Schuit; Daniel G Pipeleers; Decio L Eizirik
Inhibition of human pancreatic islet insulin release by receptor-selective somatostatin analogs directed to somatostatin receptor subtype 5.
Biochemical pharmacology 1999;57(10):1159-64.
1999: Gunilla T Westermark; Per Westermark; Decio L Eizirik; Claes Hellerström; N Fox; Donald F Steiner; Arne Andersson
Differences in amyloid deposition in islets of transgenic mice expressing human islet amyloid polypeptide versus human islets implanted into nude mice.
Metabolism: clinical and experimental 1999;48(4):448-54.
1999: M Flodström; Björn Tyrberg; Decio L Eizirik; Stellan Sandler
Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes.
Diabetes 1999;48(4):706-13.
1999: D Pavlovic; M C Chen; Luc Bouwens; Decio L Eizirik; Daniel Pipeleers
Contribution of ductal cells to cytokine responses by human pancreatic islets.
Diabetes 1999;48(1):29-33.
1998: Martine I Darville; Decio L Eizirik
Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells.
Diabetologia 1998;41(9):1101-8.
1998: Zhidong Ling; M C Chen; A Smismans; D Pavlovic; Frans Schuit; Decio L Eizirik; Daniel G Pipeleers
Intercellular differences in interleukin 1beta-induced suppression of insulin synthesis and stimulation of noninsulin protein synthesis by rat pancreatic beta-cells.
Endocrinology 1998;139(4):1540-5.
1997: Decio L Eizirik; Leif Jansson; M Flodström; Claes Hellerström; Arne Andersson
Mechanisms of defective glucose-induced insulin release in human pancreatic islets transplanted to diabetic nude mice.
The Journal of clinical endocrinology and metabolism 1997;82(8):2660-3.
1997: M Flodström; Decio L Eizirik
Interferon-gamma-induced interferon regulatory factor-1 (IRF-1) expression in rodent and human islet cells precedes nitric oxide production.
Endocrinology 1997;138(7):2747-53.
1997: Stellan Sandler; Arne Andersson; Decio L Eizirik; Claes Hellerström; Terje Espevik; Bård Kulseng; B Thu; Daniel G Pipeleers; Gudmund Skjåk-Braek
Assessment of insulin secretion in vitro from microencapsulated fetal porcine islet-like cell clusters and rat, mouse, and human pancreatic islets.
Transplantation 1997;63(12):1712-8.
1997: C A Delaney; D Pavlovic; A Hoorens; Daniel G Pipeleers; Decio L Eizirik
Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells.
Endocrinology 1997;138(6):2610-4.
1996: M A de-Mello; M Flodström; Decio L Eizirik
Ebselen and cytokine-induced nitric oxide synthase expression in insulin-producing cells.
Biochemical pharmacology 1996;52(11):1703-9.
1996: Björn Tyrberg; Decio L Eizirik; Claes Hellerström; Daniel G Pipeleers; A Andersson
Human pancreatic beta-cell deoxyribonucleic acid-synthesis in islet grafts decreases with increasing organ donor age but increases in response to glucose stimulation in vitro.
Endocrinology 1996;137(12):5694-9.
1996: C A Delaney; Björn Tyrberg; L Bouwens; H Vaghef; B Hellman; Decio L Eizirik
Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death.
FEBS letters 1996;394(3):300-6.
1996: Johan Saldeen; D T Curiel; Decio L Eizirik; A Andersson; E Strandell; Karsten Buschard; Nils Welsh
Efficient gene transfer to dispersed human pancreatic islet cells in vitro using adenovirus-polylysine/DNA complexes or polycationic liposomes.
Diabetes 1996;45(9):1197-203.
1996: M Flodström; Sidney Morris; Decio L Eizirik
Role of the citrulline-nitric oxide cycle in the functional response of adult human and rodent pancreatic islets to cytokines.
Cytokine 1996;8(8):642-50.
1996: Decio L Eizirik; M Flodström; A E Karlsen; Nils Welsh
The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells.
Diabetologia 1996;39(8):875-90.
1996: Decio L Eizirik; Peter S Spencer; Glen E Kisby
Potential role of environmental genotoxic agents in diabetes mellitus and neurodegenerative diseases.
Biochemical pharmacology 1996;51(12):1585-91.
1996: A Andersson; Decio L Eizirik; C Bremer; R C Johnson; Daniel G Pipeleers; Claes Hellerström
Structure and function of macroencapsulated human and rodent pancreatic islets transplanted into nude mice.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(6):306-9.
1996: Decio L Eizirik
Beta-cell defence and repair mechanisms in human pancreatic islets.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(6):302-5.
1996: C A Delaney; Decio L Eizirik
Intracellular targets for nitric oxide toxicity to pancreatic beta-cells.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1996;29(5):569-79.
1996: M Flodström; Nils Welsh; Decio L Eizirik
Cytokines activate the nuclear factor kappa B (NF-kappa B) and induce nitric oxide production in human pancreatic islets.
FEBS letters 1996;385(1-2):4-6.
1996: Decio L Eizirik; C A Delaney; Michael H L Green; James M Cunningham; Julian R Thorpe; Daniel G Pipeleers; Claes Hellerström; Irene C Green
Nitric oxide donors decrease the function and survival of human pancreatic islets.
Molecular and cellular endocrinology 1996;118(1-2):71-83.
1996: S Sandle; Decio L Eizirik
Culture of human pancreatic islet cells.
Methods in molecular medicine 1996;2():391-407.
1995: Leif Jansson; Decio L Eizirik; Daniel G Pipeleers; L A Håkan Borg; Claes Hellerström; A Andersson
Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice.
The Journal of clinical investigation 1995;96(2):721-6.
1995: M Flodström; A Niemann; Francisco Bedoya; Sidney Morris; Decio L Eizirik
Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic beta-cells: induction of argininosuccinate synthetase by cytokines.
Endocrinology 1995;136(8):3200-6.
1995: Decio L Eizirik; Glen E Kisby
Cycad toxin-induced damage of rodent and human pancreatic beta-cells.
Biochemical pharmacology 1995;50(3):355-65.
1995: Decio L Eizirik; Stellan Sandler; Nils Welsh; L Juntti-Berggren; Per-Olof Berggren
Interleukin-1 beta-induced stimulation of insulin release in mouse pancreatic islets is related to diacylglycerol production and protein kinase C activation.
Molecular and cellular endocrinology 1995;111(2):159-65.
1995: Francisco Bedoya; M Flodström; Decio L Eizirik
Pyrrolidine dithiocarbamate prevents IL-1-induced nitric oxide synthase mRNA, but not superoxide dismutase mRNA, in insulin producing cells.
Biochemical and biophysical research communications 1995;210(3):816-22.
1994: A Niemann; A Björklund; Decio L Eizirik
Studies on the molecular regulation of the inducible form of nitric oxide synthase (iNOS) in insulin-producing cells.
Molecular and cellular endocrinology 1994;106(1-2):151-5.
1994: Decio L Eizirik; Nils Welsh; A Sener; W J Malaisse
Protective action of succinic acid monomethyl ester against the impairment of glucose-stimulated insulin release caused by glucopenia or starvation: metabolic determinants.
Biochemical medicine and metabolic biology 1994;53(1):34-45.
1994: N Bigdeli; A Niemann; Stellan Sandler; Decio L Eizirik
Dissociation between interleukin-1 beta-induced expression of mRNA for superoxide dismutase and nitric oxide synthase in insulin-producing cells.
Biochemical and biophysical research communications 1994;203(3):1542-7.
1994: Decio L Eizirik; Daniel G Pipeleers; Z Ling; Nils Welsh; Claes Hellerström; A Andersson
Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9253-6.
1994: Jan-Olov Sandberg; A Andersson; Decio L Eizirik; Stellan Sandler
Interleukin-1 receptor antagonist prevents low dose streptozotocin induced diabetes in mice.
Biochemical and biophysical research communications 1994;202(1):543-8.
1994: M Cetkovic-Cvrlje; Decio L Eizirik
TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide.
Cytokine 1994;6(4):399-406.
1994: L A Velloso; Erik Björk; A E Ballagi; Keiko Funa; A Andersson; Kämpe Olle; F Anders Karlsson; Decio L Eizirik
Regulation of GAD expression in islets of Langerhans occurs both at the mRNA and protein level.
Molecular and cellular endocrinology 1994;102(1-2):31-7.
1994: Decio L Eizirik; Stellan Sandler; Nils Welsh; M Cetkovic-Cvrlje; A Nieman; D A Geller; Daniel G Pipeleers; Klaus Bendtzen; Claes Hellerström
Cytokines suppress human islet function irrespective of their effects on nitric oxide generation.
The Journal of clinical investigation 1994;93(5):1968-74.
1994: A Andersson; Decio L Eizirik; Claes Hellerström; R C Johnson; Daniel G Pipeleers
Morphology of encapsulated human pancreatic islets transplanted into nude mice.
Transplantation proceedings 1994;26(2):802-3.
1994: L A Velloso; Decio L Eizirik; F Anders Karlsson; Kämpe Olle
Absence of autoantibodies against glutamate decarboxylase (GAD) in the non-obese diabetic (NOD) mouse and low expression of the enzyme in mouse islets.
Clinical and experimental immunology 1994;96(1):129-37.
1994: Decio L Eizirik; F Leijerstam
The inducible form of nitric oxide synthase (iNOS) in insulin-producing cells.
Diabète & métabolisme 1994;20(2):116-22.
1994: Decio L Eizirik; Nils Welsh; A Niemann; L A Velloso; W J Malaisse
Succinic acid monomethyl ester protects rat pancreatic islet secretory potential against interleukin-1 beta (IL-1 beta) without affecting glutamate decarboxylase expression or nitric oxide production.
FEBS letters 1994;337(3):298-302.
1994: Nils Welsh; Decio L Eizirik; Stellan Sandler
Nitric oxide and pancreatic beta-cell destruction in insulin dependent diabetes mellitus: don't take NO for an answer.
Autoimmunity 1994;18(4):285-90.
1994: Decio L Eizirik; Stellan Sandler; Nils Welsh; K Bendtzen; Claes Hellerström
Nicotinamide decreases nitric oxide production and partially protects human pancreatic islets against the suppressive effects of combinations of cytokines.
Autoimmunity 1994;19(3):193-8.
1993: Jan-Olov Sandberg; Decio L Eizirik; Stellan Sandler; D E Tracey; A Andersson
Treatment with an interleukin-1 receptor antagonist protein prolongs mouse islet allograft survival.
Diabetes 1993;42(12):1845-51.
1993: Decio L Eizirik; Stellan Sandler; J P Palmer
Repair of pancreatic beta-cells. A relevant phenomenon in early IDDM?
Diabetes 1993;42(10):1383-91.
1993: M Cetkovic-Cvrlje; Stellan Sandler; Decio L Eizirik
Nicotinamide and dexamethasone inhibit interleukin-1-induced nitric oxide production by RINm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase.
Endocrinology 1993;133(4):1739-43.
1993: Decio L Eizirik; A Björklund; E Cagliero
Genotoxic agents increase expression of growth arrest and DNA damage--inducible genes gadd 153 and gadd 45 in rat pancreatic islets.
Diabetes 1993;42(5):738-45.
1993: Decio L Eizirik; A Björklund; Nils Welsh
Interleukin-1-induced expression of nitric oxide synthase in insulin-producing cells is preceded by c-fos induction and depends on gene transcription and protein synthesis.
FEBS letters 1993;317(1-2):62-6.
1993: Decio L Eizirik; N Welsh; Claes Hellerström
Predominance of stimulatory effects of interleukin-1 beta on isolated human pancreatic islets.
The Journal of clinical endocrinology and metabolism 1993;76(2):399-403.
1993: L A Velloso; Kämpe Olle; Decio L Eizirik; A Hallberg; A Andersson; F Anders Karlsson
Human autoantibodies react with glutamic acid decarboxylase antigen in human and rat but not in mouse pancreatic islets.
Diabetologia 1993;36(1):39-46.
1992: Erik Björk; Kämpe Olle; F Anders Karlsson; D G Pipeleers; A Andersson; C Hellerström; Decio L Eizirik
Glucose regulation of the autoantigen GAD65 in human pancreatic islets.
The Journal of clinical endocrinology and metabolism 1992;75(6):1574-6.
1992: E Strandell; Stellan Sandler; C Boitard; Decio L Eizirik
Role of infiltrating T cells for impaired glucose metabolism in pancreatic islets isolated from non-obese diabetic mice.
Diabetologia 1992;35(10):924-31.
1992: Decio L Eizirik; G S Korbutt; Claes Hellerström
Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function.
The Journal of clinical investigation 1992;90(4):1263-8.
1992: Decio L Eizirik; E Cagliero; A Björklund; Nils Welsh
Interleukin-1 beta induces the expression of an isoform of nitric oxide synthase in insulin-producing cells, which is similar to that observed in activated macrophages.
FEBS letters 1992;308(3):249-52.
1992: Stellan Sandler; Decio L Eizirik; C Svensson; E Strandell; Michael Welsh; Nils Welsh
[Are cytokines mediators in the development of insulin-dependent diabetes mellitus?].
Läkartidningen 1992;89(20):1777-9.
1992: L A Håkan Borg; E Cagliero; Stellan Sandler; Nils Welsh; Decio L Eizirik
Interleukin-1 beta increases the activity of superoxide dismutase in rat pancreatic islets.
Endocrinology 1992;130(5):2851-7.
1992: Decio L Eizirik; D E Tracey; K Bendtzen; Stellan Sandler
Role of receptor binding and gene transcription for both the stimulatory and inhibitory effects of interleukin-1 in pancreatic beta-cells.
Autoimmunity 1992;12(2):127-33.
1991: Nils Welsh; Decio L Eizirik; K Bendtzen; Stellan Sandler
Interleukin-1 beta-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase.
Endocrinology 1991;129(6):3167-73.
1991: Decio L Eizirik; Stellan Sandler; G Ahnström; Michael Welsh
Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induces long-lasting functional impairment of B-cells.
Biochemical pharmacology 1991;42(12):2275-82.
1991: B A Margulis; Stellan Sandler; Decio L Eizirik; Nils Welsh; Michael Welsh
Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1 beta-induced impaired beta-cell function.
Diabetes 1991;40(11):1418-22.
1991: Olle Korsgren; Leif Jansson; Decio L Eizirik; A Andersson
Functional and morphological differentiation of fetal porcine islet-like cell clusters after transplantation into nude mice.
Diabetologia 1991;34(6):379-86.
1991: Decio L Eizirik; D E Tracey; K Bendtzen; Stellan Sandler
An interleukin-1 receptor antagonist protein protects insulin-producing beta cells against suppressive effects of interleukin-1 beta.
Diabetologia 1991;34(6):445-8.
1991: Decio L Eizirik; K Bendtzen; Stellan Sandler
Short exposure of rat pancreatic islets to interleukin-1 beta induces a sustained but reversible impairment in beta-cell function: influence of protease activation, gene transcription, and protein synthesis.
Endocrinology 1991;128(3):1611-6.
1991: Decio L Eizirik; E Strandell; Stellan Sandler
Prolonged exposure of pancreatic islets isolated from "pre-diabetic" non-obese diabetic mice to a high glucose concentration does not impair beta-cell function.
Diabetologia 1991;34(1):6-11.
1991: C Hellerström; Decio L Eizirik; Nils Welsh; A Sjöholm; Leif Jansson; C Svensson; E Strandell; Olle Korsgren; Z Q Li; A Andersson
New perspectives on the structure and function of the normal and diabetic beta-cell.
Upsala journal of medical sciences 1991;96(1):1-16.
1991: Stellan Sandler; Decio L Eizirik; C Svensson; E Strandell; Michael Welsh; Nils Welsh
Biochemical and molecular actions of interleukin-1 on pancreatic beta-cells.
Autoimmunity 1991;10(3):241-53.
1991: Decio L Eizirik
Interleukin-1 beta induces an early decrease in insulin release, (pro)insulin biosynthesis and insulin mRNA in mouse pancreatic islets by a mechanism dependent on gene transcription and protein synthesis.
Autoimmunity 1991;10(2):107-13.
1991: Nils Welsh; Michael Welsh; S Lindquist; Decio L Eizirik; K Bendtzen; Stellan Sandler
Interleukin-1 beta increases the biosynthesis of the heat shock protein hsp70 and selectively decreases the biosynthesis of five proteins in rat pancreatic islets.
Autoimmunity 1991;9(1):33-40.
1990: L A Borg; Decio L Eizirik
Short-term exposure of rat pancreatic islets to human interleukin-1 beta increases cellular uptake of calcium.
Immunology letters 1990;26(3):253-8.
1990: Stellan Sandler; K Bendtzen; Decio L Eizirik; E Strandell; Michael Welsh; Nils Welsh
Metabolism and beta-cell function of rat pancreatic islets exposed to human interleukin-1 beta in the presence of a high glucose concentration.
Immunology letters 1990;26(3):245-51.
1990: Decio L Eizirik; Michael Welsh; E Strandell; Nils Welsh; Stellan Sandler
Interleukin-1 beta depletes insulin messenger ribonucleic acid and increases the heat shock protein hsp70 in mouse pancreatic islets without impairing the glucose metabolism.
Endocrinology 1990;127(5):2290-7.
1990: E Strandell; Decio L Eizirik; Stellan Sandler
Reversal of beta-cell suppression in vitro in pancreatic islets isolated from nonobese diabetic mice during the phase preceding insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1990;85(6):1944-50.
1990: Stellan Sandler; K Bendtzen; Decio L Eizirik; Michael Welsh
Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitro.
Endocrinology 1990;126(2):1288-94.
1989: Decio L Eizirik; Stellan Sandler; Olle Korsgren; Leif Jansson; A Andersson
Persistent impairment of the insulin response to glucose both in vivo and in vitro after streptozotocin exposure: studies with grafted pancreatic islets and islets maintained in culture.
Acta endocrinologica 1989;121(6):849-56.
1989: Decio L Eizirik; Stellan Sandler
Human interleukin-1 beta induced stimulation of insulin release from rat pancreatic islets is accompanied by an increase in mitochondrial oxidative events.
Diabetologia 1989;32(11):769-73.
1989: Stellan Sandler; K Bendtzen; Decio L Eizirik; A Sjöholm; Nils Welsh
Decreased cell replication and polyamine content in insulin-producing cells after exposure to human interleukin 1 beta.
Immunology letters 1989;22(4):267-72.
1989: Decio L Eizirik; Stellan Sandler
Sustained exposure of toxically damaged mouse pancreatic islets to high glucose does not increase beta-cell dysfunction.
The Journal of endocrinology 1989;123(1):47-51.
1989: Decio L Eizirik; Stellan Sandler
Function and metabolism of pancreatic beta-cells maintained in culture following experimentally induced damage.
Pharmacology & toxicology 1989;65(3):163-8.
1989: Decio L Eizirik; Stellan Sandler; A Hallberg; K Bendtzen; A Sener; W J Malaisse
Differential sensitivity to beta-cell secretagogues in cultured rat pancreatic islets exposed to human interleukin-1 beta.
Endocrinology 1989;125(2):752-9.
1989: E Strandell; Decio L Eizirik; Stellan Sandler
Survival and B-cell function of mouse pancreatic islets maintained in culture after concomitant exposure to streptozotocin and nicotinamide.
Experimental and clinical endocrinology 1989;93(2-3):219-24.
1989: Stellan Sandler; K Bendtzen; L A Håkan Borg; Decio L Eizirik; E Strandell; Nils Welsh
Studies on the mechanisms causing inhibition of insulin secretion in rat pancreatic islets exposed to human interleukin-1 beta indicate a perturbation in the mitochondrial function.
Endocrinology 1989;124(3):1492-501.
1988: Decio L Eizirik; Stellan Sandler
Functional restoration of cultured mouse pancreatic islets after in vitro exposure to alloxan.
Pharmacology & toxicology 1988;63(5):396-9.
1988: Decio L Eizirik
Interleukin-1 induced impairment in pancreatic islet oxidative metabolism of glucose is potentiated by tumor necrosis factor.
Acta endocrinologica 1988;119(3):321-5.
1988: E Strandell; Decio L Eizirik; Olle Korsgren; Stellan Sandler
Functional characteristics of cultured mouse pancreatic islets following exposure to different streptozotocin concentrations.
Molecular and cellular endocrinology 1988;59(1-2):83-91.
1988: Decio L Eizirik; Stellan Sandler; A Sener; W J Malaisse
Defective catabolism of D-glucose and L-glutamine in mouse pancreatic islets maintained in culture after streptozotocin exposure.
Endocrinology 1988;123(2):1001-7.
1988: Decio L Eizirik; E Strandell; K Bendtzen; Stellan Sandler
Functional characteristics of rat pancreatic islets maintained in culture after exposure to human interleukin 1.
Diabetes 1988;37(7):916-9.
1988: Michael Welsh; Decio L Eizirik; E Strandell
Heat-shock treatment of mouse pancreatic islets results in a partial loss of islet cells but no remaining functional impairment among the surviving beta cells.
Journal of molecular endocrinology 1988;1(1):27-31.
1988: Decio L Eizirik; Stellan Sandler; Nils Welsh; Claes Hellerström
Preferential reduction of insulin production in mouse pancreatic islets maintained in culture after streptozotocin exposure.
Endocrinology 1988;122(4):1242-9.
1988: Decio L Eizirik; E Strandell; Stellan Sandler
Culture of mouse pancreatic islets in different glucose concentrations modifies B cell sensitivity to streptozotocin.
Diabetologia 1988;31(3):168-74.
1987: Decio L Eizirik; Stellan Sandler
The partial protective effect of branched chain amino acids against streptozotocin-induced cytotoxicity to mouse pancreatic islets in vitro.
Pharmacology & toxicology 1987;61(5):320-4.