Decio Eizirik

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García Mónica; Dogusan Zeynep; Moore Fabrice; Sato Shintaro; Hartmann Gunther; Eizirik Decio L; Rasschaert Joanne
Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells.
Gurzov E N; Ortis F; Cunha D A; Gosset G; Li M; Cardozo A K; Eizirik D L
Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis.
Li Ning; Brun Thierry; Cnop Miriam; Cunha Daniel A; Eizirik Decio L; Maechler Pierre
Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction.

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2009: García Mónica; Dogusan Zeynep; Moore Fabrice; Sato Shintaro; Hartmann Gunther; Eizirik Decio L; Rasschaert Joanne
Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells.
Biochimica et biophysica acta 2009;1793(11):1768-75.
2009: Gurzov E N; Ortis F; Cunha D A; Gosset G; Li M; Cardozo A K; Eizirik D L
Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis.
Cell death and differentiation 2009;16(11):1539-50.
2009: Li Ning; Brun Thierry; Cnop Miriam; Cunha Daniel A; Eizirik Decio L; Maechler Pierre
Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction.
The Journal of biological chemistry 2009;284(35):23602-12.
2009: Moore Fabrice; Colli Maikel L; Cnop Miriam; Esteve Mariana Igoillo; Cardozo Alessandra K; Cunha Daniel A; Bugliani Marco; Marchetti Piero; Eizirik Décio L
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.
Diabetes 2009;58(6):1283-91.
2009: Eizirik Decio L
Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes: response to Nathan et al.
Diabetes care 2009;32(3):e35-6; author reply e37-8.
2009: Kutlu Burak; Burdick David; Baxter David; Rasschaert Joanne; Flamez Daisy; Eizirik Decio L; Welsh Nils; Goodman Nathan; Hood Leroy
Detailed transcriptome atlas of the pancreatic beta cell.
BMC medical genomics 2009;2():3.
2008: Cnop Miriam; Igoillo-Esteve Mariana; Cunha Daniel A; Ladrière Laurence; Eizirik Décio L
An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells.
Biochemical Society transactions 2008;36(Pt 5):909-15.
2008: Cunha Daniel A; Hekerman Paul; Ladrière Laurence; Bazarra-Castro Angie; Ortis Fernanda; Wakeham Marion C; Moore Fabrice; Rasschaert Joanne; Cardozo Alessandra K; Bellomo Elisa; Overbergh Lutgart; Mathieu Chantal; Lupi Roberto; Hai Tsonwin; Herchuelz Andre; Marchetti Piero; Rutter Guy A; Eizirik Décio L; Cnop Miriam
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.
Journal of cell science 2008;121(Pt 14):2308-18.
2008: Ortis F; Pirot P; Naamane N; Kreins A Y; Rasschaert J; Moore F; Théâtre E; Verhaeghe C; Magnusson N E; Chariot A; Orntoft T F; Eizirik D L
Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.
Diabetologia 2008;51(7):1213-25.
2008: Eizirik Decio L; Moore Fabrice; Flamez Daisy; Ortis Fernanda
Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes.
Biochemical Society transactions 2008;36(Pt 3):321-7.
2008: Dogusan Zeynep; García Mónica; Flamez Daisy; Alexopoulou Lena; Goldman Michel; Gysemans Conny; Mathieu Chantal; Libert Claude; Eizirik Decio L; Rasschaert Joanne
Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways.
Diabetes 2008;57(5):1236-45.
2008: Guri Amir J; Hontecillas Raquel; Ferrer Gerardo; Casagran Oriol; Wankhade Umesh; Noble Alexis M; Eizirik Decio L; Ortis Fernanda; Cnop Miriam; Liu Dongmin; Si Hongwei; Bassaganya-Riera Josep
Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue.
The Journal of nutritional biochemistry 2008;19(4):216-28.
2008: Pirot Pierre; Cardozo Alessandra K; Eizirik Décio L
Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes.
Arquivos brasileiros de endocrinologia e metabologia 2008;52(2):156-65.
2008: Eizirik Décio L; Cardozo Alessandra K; Cnop Miriam
The role for endoplasmic reticulum stress in diabetes mellitus.
Endocrine reviews 2008;29(1):42-61.
2008: Gurzov Esteban N; Ortis Fernanda; Bakiri Latifa; Wagner Erwin F; Eizirik Decio L
JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells.
PloS one 2008;3(8):e3030.
2007: D'Hertog Wannes; Overbergh Lut; Lage Kasper; Ferreira Gabriela Bonfim; Maris Michael; Gysemans Conny; Flamez Daisy; Cardozo Alessandra Kupper; Van den Bergh Gert; Schoofs Liliane; Arckens Lut; Moreau Yves; Hansen Daniel Aaen; Eizirik Decio Laks; Waelkens Ettienne; Mathieu Chantal
Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved.
Molecular & cellular proteomics : MCP 2007;6(12):2180-99.
2007: Marchetti P; Bugliani M; Lupi R; Marselli L; Masini M; Boggi U; Filipponi F; Weir G C; Eizirik D L; Cnop M
The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.
Diabetologia 2007;50(12):2486-94.
2007: Cardozo Alessandra K; Buchillier Valérie; Mathieu Marc; Chen Jianhua; Ortis Fernanda; Ladrière Laurence; Allaman-Pillet Nathalie; Poirot Olivier; Kellenberger Stephan; Beckmann Jacques S; Eizirik Decio L; Bonny Christophe; Maurer Fabienne
Cell-permeable peptides induce dose- and length-dependent cytotoxic effects.
Biochimica et biophysica acta 2007;1768(9):2222-34.
2007: Callewaert Hanne I; Gysemans Conny A; Ladrière Laurence; D'Hertog Wannes; Hagenbrock Julianna; Overbergh Lutgart; Eizirik Decio L; Mathieu Chantal
Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection.
Diabetes 2007;56(8):2169-73.
2007: Pirot P; Naamane N; Libert F; Magnusson N E; Ørntoft T F; Cardozo A K; Eizirik D L
Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs.
Diabetologia 2007;50(5):1006-14.
2007: Pirot Pierre; Ortis Fernanda; Cnop Miriam; Ma Yanjun; Hendershot Linda M; Eizirik Décio L; Cardozo Alessandra K
Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells.
Diabetes 2007;56(4):1069-77.
2007: Cnop Miriam; Ladriere Laurence; Hekerman Paul; Ortis Fernanda; Cardozo Alessandra K; Dogusan Zeynep; Flamez Daisy; Boyce Michael; Yuan Junying; Eizirik Decio L
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.
The Journal of biological chemistry 2007;282(6):3989-97.
2007: Hulbert Erin M; Smink Luc J; Adlem Ellen C; Allen James E; Burdick David B; Burren Oliver S; Cassen Victor M; Cavnor Christopher C; Dolman Geoffrey E; Flamez Daisy; Friery Karen F; Healy Barry C; Killcoyne Sarah A; Kutlu Burak; Schuilenburg Helen; Walker Neil M; Mychaleckyj Josyf; Eizirik Decio L; Wicker Linda S; Todd John A; Goodman Nathan
T1DBase: integration and presentation of complex data for type 1 diabetes research.
Nucleic acids research 2007;35(Database issue):D742-6.
2007: Callewaert H; Gysemans C; Cardozo A K; Elsner M; Tiedge M; Eizirik D L; Mathieu C
Cell loss during pseudoislet formation hampers profound improvements in islet lentiviral transduction efficacy for transplantation purposes.
Cell transplantation 2007;16(5):527-37.
2007: Naamane Najib; van Helden Jacques; Eizirik Decio L
In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells.
BMC bioinformatics 2007;8():55.
2006: Kharroubi I; Lee C-H; Hekerman P; Darville M I; Evans R M; Eizirik D L; Cnop M
BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells.
Diabetologia 2006;49(10):2350-8.
2006: Ortis Fernanda; Cardozo Alessandra K; Crispim Daisy; Störling Joachim; Mandrup-Poulsen Thomas; Eizirik Décio L
Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.
Molecular endocrinology (Baltimore, Md.) 2006;20(8):1867-79.
2006: Pirot P; Eizirik D L; Cardozo A K
Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms.
Diabetologia 2006;49(6):1229-36.
2006: Darville Martine I; Eizirik Décio L
Notch signaling: a mediator of beta-cell de-differentiation in diabetes?
Biochemical and biophysical research communications 2006;339(4):1063-8.
2006: Eizirik Decio L
Using genomics and systems biology to address complex problems: pancreatic Beta cell apoptosis in diabetes mellitus.
ALTEX : Alternativen zu Tierexperimenten 2006;23 Suppl():385-7.
2005: Cnop Miriam; Welsh Nils; Jonas Jean-Christophe; Jörns Anne; Lenzen Sigurd; Eizirik Decio L
Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.
Diabetes 2005;54 Suppl 2():S97-107.
2005: Larsen L; Størling J; Darville M; Eizirik D L; Bonny C; Billestrup N; Mandrup-Poulsen T
Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells.
Diabetologia 2005;48(12):2582-90.
2005: Guo Dehuang; Han Junyan; Adam Bao-Ling; Colburn Nancy H; Wang Mong-Heng; Dong Zheng; Eizirik Decio L; She Jin-Xiong; Wang Cong-Yi
Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.
Biochemical and biophysical research communications 2005;337(4):1308-18.
2005: Welsh Nils; Cnop Miriam; Kharroubi Ilham; Bugliani Marco; Lupi Roberto; Marchetti Piero; Eizirik Décio L
Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?
Diabetes 2005;54(11):3238-44.
2005: Rasschaert Joanne; Ladrière Laurence; Urbain Maryse; Dogusan Zeynep; Katabua Bitty; Sato Shintaro; Akira Shizuo; Gysemans Conny; Mathieu Chantal; Eizirik Decio L
Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells.
The Journal of biological chemistry 2005;280(40):33984-91.
2005: Gysemans Conny A; Ladrière Laurence; Callewaert Hanne; Rasschaert Joanne; Flamez Daisy; Levy David E; Matthys Patrick; Eizirik Décio L; Mathieu Chantal
Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.
Diabetes 2005;54(8):2396-403.
2005: Ylipaasto P; Kutlu B; Rasilainen S; Rasschaert J; Salmela K; Teerijoki H; Korsgren O; Lahesmaa R; Hovi T; Eizirik D L; Otonkoski T; Roivainen M
Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets.
Diabetologia 2005;48(8):1510-22.
2005: Li Manyu; Guo Dehuang; Isales Carlos M; Eizirik Decio L; Atkinson Mark; She Jin-Xiong; Wang Cong-Yi
SUMO wrestling with type 1 diabetes.
Journal of molecular medicine (Berlin, Germany) 2005;83(7):504-13.
2005: Gysemans Conny A; Cardozo Alessandra K; Callewaert Hanne; Giulietti Annapaula; Hulshagen Leen; Bouillon Roger; Eizirik Décio L; Mathieu Chantal
1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice.
Endocrinology 2005;146(4):1956-64.
2005: Cardozo Alessandra K; Ortis Fernanda; Storling Joachim; Feng Ying-Mei; Rasschaert Joanne; Tonnesen Morten; Van Eylen Françoise; Mandrup-Poulsen Thomas; Herchuelz André; Eizirik Décio L
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.
Diabetes 2005;54(2):452-61.
2005: Smink Luc J; Helton Erin M; Healy Barry C; Cavnor Christopher C; Lam Alex C; Flamez Daisy; Burren Oliver S; Wang Yang; Dolman Geoffrey E; Burdick David B; Everett Vincent H; Glusman Gustavo; Laneri Davide; Rowen Lee; Schuilenburg Helen; Walker Neil M; Mychaleckyj Josyf; Wicker Linda S; Eizirik Decio L; Todd John A; Goodman Nathan
T1DBase, a community web-based resource for type 1 diabetes research.
Nucleic acids research 2005;33(Database issue):D544-9.
2005: Magnusson Nils E; Cardozo Alessandra K; Kruhøffer Mogens; Eizirik Decio L; Ørntoft Torben F; Jensen Jens L
Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis.
BMC bioinformatics 2005;6():311.
2004: Kutlu Burak; Naamane Najib; Berthou Laurence; Eizirik Decio L
New approaches for in silico identification of cytokine-modified beta cell gene networks.
Annals of the New York Academy of Sciences 2004;1037():41-58.
2004: Karlsen A E; Heding P E; Frobøse H; Rønn S G; Kruhøffer M; Orntoft T F; Darville M; Eizirik D L; Pociot F; Nerup J; Mandrup-Poulsen T; Billestrup N
Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.
Diabetologia 2004;47(11):1998-2011.
2004: Kharroubi Ilham; Ladrière Laurence; Cardozo Alessandra K; Dogusan Zeynep; Cnop Miriam; Eizirik Décio L
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.
Endocrinology 2004;145(11):5087-96.
2004: De Ridder Mark; Verovski Valeri N; Darville Martine I; Van Den Berge Dirk L; Monsaert Christinne; Eizirik Decio L; Storme Guy A
Macrophages enhance the radiosensitizing activity of lipid A: a novel role for immune cells in tumor cell radioresponse.
International journal of radiation oncology, biology, physics 2004;60(2):598-606.
2004: Ohara-Imaizumi Mica; Cardozo Alessandra K; Kikuta Toshiteru; Eizirik Decio L; Nagamatsu Shinya
The cytokine interleukin-1beta reduces the docking and fusion of insulin granules in pancreatic beta-cells, preferentially decreasing the first phase of exocytosis.
The Journal of biological chemistry 2004;279(40):41271-4.
2004: Vermijlen David; Seynaeve Carine; Luo Dianzhong; Kruhøffer Mogens; Eizirik Decio L; Ørntoft Torben F; Wisse Eddie
High-density oligonucleotide array analysis reveals extensive differences between freshly isolated blood and hepatic natural killer cells.
European journal of immunology 2004;34(9):2529-40.
2004: Darville Martine I; Terryn Sara; Eizirik Décio L
An octamer motif is required for activation of the inducible nitric oxide synthase promoter in pancreatic beta-cells.
Endocrinology 2004;145(3):1130-6.
2003: Kharroubi Ilham; Rasschaert Joanne; Eizirik Décio L; Cnop Miriam
Expression of adiponectin receptors in pancreatic beta cells.
Biochemical and biophysical research communications 2003;312(4):1118-22.
2003: Rasschaert J; Liu D; Kutlu B; Cardozo A K; Kruhøffer M; ØRntoft T F; Eizirik D L
Global profiling of double stranded RNA- and IFN-gamma-induced genes in rat pancreatic beta cells.
Diabetologia 2003;46(12):1641-57.
2003: Eizirik Decio L; Kutlu Burak; Rasschaert Joanne; Darville Martine; Cardozo Alessandra K
Use of microarray analysis to unveil transcription factor and gene networks contributing to Beta cell dysfunction and apoptosis.
Annals of the New York Academy of Sciences 2003;1005():55-74.
2003: Kutlu Burak; Cardozo Alessandra K; Darville Martine I; Kruhøffer Mogens; Magnusson Nils; Ørntoft Torben; Eizirik Décio L
Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells.
Diabetes 2003;52(11):2701-19.
2003: Cardozo Alessandra K; Berthou Laurence; Kruhøffer Mogens; Orntoft Torben; Nicolls Mark R; Eizirik Decio L
Gene microarray study corroborates proteomic findings in rodent islet cells.
Journal of proteome research 2003;2(5):553-5.
2003: Cardozo A K; Proost P; Gysemans C; Chen M-C; Mathieu C; Eizirik D L
IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice.
Diabetologia 2003;46(2):255-66.
2003: Kutlu Burak; Darville Martine I; Cardozo Alessandra K; Eizirik Décio L
Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells.
Diabetes 2003;52(2):348-55.
2003: Azevedo-Martins Anna Karenina; Lortz Stephan; Lenzen Sigurd; Curi Rui; Eizirik Decio L; Tiedge Markus
Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells.
Diabetes 2003;52(1):93-101.
2002: Liu Dongbo; Cardozo Alessandra K; Darville Martine I; Eizirik Décio L
Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.
Endocrinology 2002;143(4):1225-34.
2002: Vanderkerken Karin; Vande Broek Isabelle; Eizirik Décio L; Van Valckenborgh Els; Asosingh Kewal; Van Riet Ivan; Van Camp Ben
Monocyte chemoattractant protein-1 (MCP-1), secreted by bone marrow endothelial cells, induces chemoattraction of 5T multiple myeloma cells.
Clinical & experimental metastasis 2002;19(1):87-90.
2001: Eizirik D L; Mandrup-Poulsen T
A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis.
Diabetologia 2001;44(12):2115-33.
2001: Cardozo A K; Heimberg H; Heremans Y; Leeman R; Kutlu B; Kruhøffer M; Ørntoft T; Eizirik D L
A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells.
The Journal of biological chemistry 2001;276(52):48879-86.
2001: Heimberg H; Heremans Y; Jobin C; Leemans R; Cardozo A K; Darville M; Eizirik D L
Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis.
Diabetes 2001;50(10):2219-24.
2001: Cnop M; Hannaert J C; Hoorens A; Eizirik D L; Pipeleers D G
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.
Diabetes 2001;50(8):1771-7.
2001: Darville M I; Eizirik D L
Cytokine induction of Fas gene expression in insulin-producing cells requires the transcription factors NF-kappaB and C/EBP.
Diabetes 2001;50(8):1741-8.
2001: Liu D; Darville M; Eizirik D L
Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis.
Endocrinology 2001;142(6):2593-9.
2001: Gysemans C A; Pavlovic D; Bouillon R; Eizirik D L; Mathieu C
Dual role of interferon-gamma signalling pathway in sensitivity of pancreatic beta cells to immune destruction.
Diabetologia 2001;44(5):567-74.
2001: Cardozo A K; Kruhøffer M; Leeman R; Orntoft T; Eizirik D L
Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays.
Diabetes 2001;50(5):909-20.
2001: Chen M C; Proost P; Gysemans C; Mathieu C; Eizirik D L
Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells.
Diabetologia 2001;44(3):325-32.
2001: Darville M I; Liu D; Chen M C; Eizirik D L
Molecular regulation of Fas expression in beta-cells.
Diabetes 2001;50 Suppl 1():S83.
2001: Eizirik D L; Darville M I
beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes.
Diabetes 2001;50 Suppl 1():S64-9.
2000: Nikulina M A; Andersen H U; Karlsen A E; Darville M I; Eizirik D L; Mandrup-Poulsen T
Glutathione depletion inhibits IL-1 beta-stimulated nitric oxide production by reducing inducible nitric oxide synthase gene expression.
Cytokine 2000;12(9):1391-4.
2000: Chen M C; Paez-Espinosa V; Welsh N; Eizirik D L
Interleukin-1beta regulates phospholipase D-1 expression in rat pancreatic beta-cells.
Endocrinology 2000;141(8):2822-8.
2000: Liu D; Pavlovic D; Chen M C; Flodström M; Sandler S; Eizirik D L
Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).
Diabetes 2000;49(7):1116-22.
2000: Pavlovic D; Andersen N A; Mandrup-Poulsen T; Eizirik D L
Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic beta-cells.
European cytokine network 2000;11(2):267-74.
2000: Hong T P; Andersen N A; Nielsen K; Karlsen A E; Fantuzzi G; Eizirik D L; Dinarello C A; Mandrup-Poulsen T
Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma.
European cytokine network 2000;11(2):193-205.
2000: Karlsen A E; Pavlovic D; Nielsen K; Jensen J; Andersen H U; Pociot F; Mandrup-Poulsen T; Eizirik D L; Nerup J
Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism.
The Journal of clinical endocrinology and metabolism 2000;85(2):830-6.
2000: Roivainen M; Rasilainen S; Ylipaasto P; Nissinen R; Ustinov J; Bouwens L; Eizirik D L; Hovi T; Otonkoski T
Mechanisms of coxsackievirus-induced damage to human pancreatic beta-cells.
The Journal of clinical endocrinology and metabolism 2000;85(1):432-40.
2000: Smismans A; Eizirik D L; Pipeleers D G
Interleukin-1beta induces ornithine decarboxylase activity in insulin-producing cells.
Cytokine 2000;12(1):49-54.
2000: Darville M I; Ho Y S; Eizirik D L
NF-kappaB is required for cytokine-induced manganese superoxide dismutase expression in insulin-producing cells.
Endocrinology 2000;141(1):153-62.
2000: Sandler S; Andersson A K; Barbu A; Hellerström C; Holstad M; Karlsson E; Sandberg J O; Strandell E; Saldeen J; Sternesjö J; Tillmar L; Eizirik D L; Flodström M; Welsh N
Novel experimental strategies to prevent the development of type 1 diabetes mellitus.
Upsala journal of medical sciences 2000;105(2):17-34.
1999: Tyrberg B; Eizirik D L; Marklund S L; Olejnicka B; Madsen O D; Andersson A
Human islets in mixed islet grafts protect mouse pancreatic beta-cells from alloxan toxicity.
Pharmacology & toxicology 1999;85(6):269-75.
1999: Chen M C; Schuit F; Pipeleers D G; Eizirik D L
IL-1beta induces serine protease inhibitor 3 (SPI-3) gene expression in rat pancreatic beta-cells. Detection by differential display of messenger RNA.
Cytokine 1999;11(11):856-62.
1999: Pavlovic D; Chen M C; Gysemans C A; Mathieu C; Eizirik D L
The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic beta-cells.
European cytokine network 1999;10(3):403-12.
1999: Hostens K; Pavlovic D; Zambre Y; Ling Z; Van Schravendijk C; Eizirik D L; Pipeleers D G
Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release.
The Journal of clinical investigation 1999;104(1):67-72.
1999: Flodström M; Chen M C; Smismans A; Schuit F; Pipeleers D G; Eizirik D L
Interleukin 1beta increases arginine accumulation and activates the citrulline-NO cycle in rat pancreatic beta cells.
Cytokine 1999;11(6):400-7.
1999: Zambre Y; Ling Z; Chen M C; Hou X; Woon C W; Culler M; Taylor J E; Coy D H; Van Schravendijk C; Schuit F; Pipeleers D G; Eizirik D L
Inhibition of human pancreatic islet insulin release by receptor-selective somatostatin analogs directed to somatostatin receptor subtype 5.
Biochemical pharmacology 1999;57(10):1159-64.
1999: Westermark G; Westermark P; Eizirik D L; Hellerström C; Fox N; Steiner D F; Andersson A
Differences in amyloid deposition in islets of transgenic mice expressing human islet amyloid polypeptide versus human islets implanted into nude mice.
Metabolism: clinical and experimental 1999;48(4):448-54.
1999: Flodström M; Tyrberg B; Eizirik D L; Sandler S
Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes.
Diabetes 1999;48(4):706-13.
1999: Pavlovic D; Chen M C; Bouwens L; Eizirik D L; Pipeleers D
Contribution of ductal cells to cytokine responses by human pancreatic islets.
Diabetes 1999;48(1):29-33.
1998: Darville M I; Eizirik D L
Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells.
Diabetologia 1998;41(9):1101-8.
1998: Ling Z; Chen M C; Smismans A; Pavlovic D; Schuit F; Eizirik D L; Pipeleers D G
Intercellular differences in interleukin 1beta-induced suppression of insulin synthesis and stimulation of noninsulin protein synthesis by rat pancreatic beta-cells.
Endocrinology 1998;139(4):1540-5.
1997: Eizirik D L; Jansson L; Flodström M; Hellerström C; Andersson A
Mechanisms of defective glucose-induced insulin release in human pancreatic islets transplanted to diabetic nude mice.
The Journal of clinical endocrinology and metabolism 1997;82(8):2660-3.
1997: Flodström M; Eizirik D L
Interferon-gamma-induced interferon regulatory factor-1 (IRF-1) expression in rodent and human islet cells precedes nitric oxide production.
Endocrinology 1997;138(7):2747-53.
1997: Sandler S; Andersson A; Eizirik D L; Hellerström C; Espevik T; Kulseng B; Thu B; Pipeleers D G; Skjåk-Braek G
Assessment of insulin secretion in vitro from microencapsulated fetal porcine islet-like cell clusters and rat, mouse, and human pancreatic islets.
Transplantation 1997;63(12):1712-8.
1997: Delaney C A; Pavlovic D; Hoorens A; Pipeleers D G; Eizirik D L
Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells.
Endocrinology 1997;138(6):2610-4.
1996: de-Mello M A; Flodström M; Eizirik D L
Ebselen and cytokine-induced nitric oxide synthase expression in insulin-producing cells.
Biochemical pharmacology 1996;52(11):1703-9.
1996: Tyrberg B; Eizirik D L; Hellerström C; Pipeleers D G; Andersson A
Human pancreatic beta-cell deoxyribonucleic acid-synthesis in islet grafts decreases with increasing organ donor age but increases in response to glucose stimulation in vitro.
Endocrinology 1996;137(12):5694-9.
1996: Delaney C A; Tyrberg B; Bouwens L; Vaghef H; Hellman B; Eizirik D L
Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death.
FEBS letters 1996;394(3):300-6.
1996: Saldeen J; Curiel D T; Eizirik D L; Andersson A; Strandell E; Buschard K; Welsh N
Efficient gene transfer to dispersed human pancreatic islet cells in vitro using adenovirus-polylysine/DNA complexes or polycationic liposomes.
Diabetes 1996;45(9):1197-203.
1996: Flodström M; Morris S M; Eizirik D L
Role of the citrulline-nitric oxide cycle in the functional response of adult human and rodent pancreatic islets to cytokines.
Cytokine 1996;8(8):642-50.
1996: Eizirik D L; Flodström M; Karlsen A E; Welsh N
The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells.
Diabetologia 1996;39(8):875-90.
1996: Andersson A; Eizirik D L; Bremer C; Johnson R C; Pipeleers D G; Hellerström C
Structure and function of macroencapsulated human and rodent pancreatic islets transplanted into nude mice.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(6):306-9.
1996: Eizirik D L
Beta-cell defence and repair mechanisms in human pancreatic islets.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(6):302-5.
1996: Eizirik D L; Spencer P; Kisby G E
Potential role of environmental genotoxic agents in diabetes mellitus and neurodegenerative diseases.
Biochemical pharmacology 1996;51(12):1585-91.
1996: Delaney C A; Eizirik D L
Intracellular targets for nitric oxide toxicity to pancreatic beta-cells.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1996;29(5):569-79.
1996: Eizirik D L; Delaney C A; Green M H; Cunningham J M; Thorpe J R; Pipeleers D G; Hellerström C; Green I C
Nitric oxide donors decrease the function and survival of human pancreatic islets.
Molecular and cellular endocrinology 1996;118(1-2):71-83.
1996: Flodström M; Welsh N; Eizirik D L
Cytokines activate the nuclear factor kappa B (NF-kappa B) and induce nitric oxide production in human pancreatic islets.
FEBS letters 1996;385(1-2):4-6.
1995: Jansson L; Eizirik D L; Pipeleers D G; Borg L A; Hellerström C; Andersson A
Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice.
The Journal of clinical investigation 1995;96(2):721-6.
1995: Flodström M; Niemann A; Bedoya F J; Morris S M; Eizirik D L
Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic beta-cells: induction of argininosuccinate synthetase by cytokines.
Endocrinology 1995;136(8):3200-6.
1995: Eizirik D L; Kisby G E
Cycad toxin-induced damage of rodent and human pancreatic beta-cells.
Biochemical pharmacology 1995;50(3):355-65.
1995: Eizirik D L; Sandler S; Welsh N; Juntti-Berggren L; Berggren P O
Interleukin-1 beta-induced stimulation of insulin release in mouse pancreatic islets is related to diacylglycerol production and protein kinase C activation.
Molecular and cellular endocrinology 1995;111(2):159-65.
1995: Bedoya F J; Flodström M; Eizirik D L
Pyrrolidine dithiocarbamate prevents IL-1-induced nitric oxide synthase mRNA, but not superoxide dismutase mRNA, in insulin producing cells.
Biochemical and biophysical research communications 1995;210(3):816-22.
1994: Niemann A; Björklund A; Eizirik D L
Studies on the molecular regulation of the inducible form of nitric oxide synthase (iNOS) in insulin-producing cells.
Molecular and cellular endocrinology 1994;106(1-2):151-5.
1994: Eizirik D L; Welsh N; Sener A; Malaisse W J
Protective action of succinic acid monomethyl ester against the impairment of glucose-stimulated insulin release caused by glucopenia or starvation: metabolic determinants.
Biochemical medicine and metabolic biology 1994;53(1):34-45.
1994: Eizirik D L; Pipeleers D G; Ling Z; Welsh N; Hellerström C; Andersson A
Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9253-6.
1994: Bigdeli N; Niemann A; Sandler S; Eizirik D L
Dissociation between interleukin-1 beta-induced expression of mRNA for superoxide dismutase and nitric oxide synthase in insulin-producing cells.
Biochemical and biophysical research communications 1994;203(3):1542-7.
1994: Sandberg J O; Andersson A; Eizirik D L; Sandler S
Interleukin-1 receptor antagonist prevents low dose streptozotocin induced diabetes in mice.
Biochemical and biophysical research communications 1994;202(1):543-8.
1994: Cetkovic-Cvrlje M; Eizirik D L
TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide.
Cytokine 1994;6(4):399-406.
1994: Velloso L A; Björk E; Ballagi A E; Funa K; Andersson A; Kämpe O; Karlsson F A; Eizirik D L
Regulation of GAD expression in islets of Langerhans occurs both at the mRNA and protein level.
Molecular and cellular endocrinology 1994;102(1-2):31-7.
1994: Eizirik D L; Sandler S; Welsh N; Cetkovic-Cvrlje M; Nieman A; Geller D A; Pipeleers D G; Bendtzen K; Hellerström C
Cytokines suppress human islet function irrespective of their effects on nitric oxide generation.
The Journal of clinical investigation 1994;93(5):1968-74.
1994: Andersson A; Eizirik D L; Hellerström C; Johnson R C; Pipeleers D G
Morphology of encapsulated human pancreatic islets transplanted into nude mice.
Transplantation proceedings 1994;26(2):802-3.
1994: Velloso L A; Eizirik D L; Karlsson F A; Kämpe O
Absence of autoantibodies against glutamate decarboxylase (GAD) in the non-obese diabetic (NOD) mouse and low expression of the enzyme in mouse islets.
Clinical and experimental immunology 1994;96(1):129-37.
1994: Eizirik D L; Leijerstam F
The inducible form of nitric oxide synthase (iNOS) in insulin-producing cells.
Diabète & métabolisme 1994;20(2):116-22.
1994: Eizirik D L; Welsh N; Niemann A; Velloso L A; Malaisse W J
Succinic acid monomethyl ester protects rat pancreatic islet secretory potential against interleukin-1 beta (IL-1 beta) without affecting glutamate decarboxylase expression or nitric oxide production.
FEBS letters 1994;337(3):298-302.
1994: Welsh N; Eizirik D L; Sandler S
Nitric oxide and pancreatic beta-cell destruction in insulin dependent diabetes mellitus: don't take NO for an answer.
Autoimmunity 1994;18(4):285-90.
1994: Eizirik D L; Sandler S; Welsh N; Bendtzen K; Hellerström C
Nicotinamide decreases nitric oxide production and partially protects human pancreatic islets against the suppressive effects of combinations of cytokines.
Autoimmunity 1994;19(3):193-8.
1993: Sandberg J O; Eizirik D L; Sandler S; Tracey D E; Andersson A
Treatment with an interleukin-1 receptor antagonist protein prolongs mouse islet allograft survival.
Diabetes 1993;42(12):1845-51.
1993: Eizirik D L; Sandler S; Palmer J P
Repair of pancreatic beta-cells. A relevant phenomenon in early IDDM?
Diabetes 1993;42(10):1383-91.
1993: Cetkovic-Cvrlje M; Sandler S; Eizirik D L
Nicotinamide and dexamethasone inhibit interleukin-1-induced nitric oxide production by RINm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase.
Endocrinology 1993;133(4):1739-43.
1993: Eizirik D L; Björklund A; Cagliero E
Genotoxic agents increase expression of growth arrest and DNA damage--inducible genes gadd 153 and gadd 45 in rat pancreatic islets.
Diabetes 1993;42(5):738-45.
1993: Eizirik D L; Welsh N; Hellerström C
Predominance of stimulatory effects of interleukin-1 beta on isolated human pancreatic islets.
The Journal of clinical endocrinology and metabolism 1993;76(2):399-403.
1993: Eizirik D L; Björklund A; Welsh N
Interleukin-1-induced expression of nitric oxide synthase in insulin-producing cells is preceded by c-fos induction and depends on gene transcription and protein synthesis.
FEBS letters 1993;317(1-2):62-6.
1993: Velloso L A; Kämpe O; Eizirik D L; Hallberg A; Andersson A; Karlsson F A
Human autoantibodies react with glutamic acid decarboxylase antigen in human and rat but not in mouse pancreatic islets.
Diabetologia 1993;36(1):39-46.
1992: Björk E; Kämpe O; Karlsson F A; Pipeleers D G; Andersson A; Hellerström C; Eizirik D L
Glucose regulation of the autoantigen GAD65 in human pancreatic islets.
The Journal of clinical endocrinology and metabolism 1992;75(6):1574-6.
1992: Strandell E; Sandler S; Boitard C; Eizirik D L
Role of infiltrating T cells for impaired glucose metabolism in pancreatic islets isolated from non-obese diabetic mice.
Diabetologia 1992;35(10):924-31.
1992: Eizirik D L; Korbutt G S; Hellerström C
Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function.
The Journal of clinical investigation 1992;90(4):1263-8.
1992: Eizirik D L; Cagliero E; Björklund A; Welsh N
Interleukin-1 beta induces the expression of an isoform of nitric oxide synthase in insulin-producing cells, which is similar to that observed in activated macrophages.
FEBS letters 1992;308(3):249-52.
1992: Sandler S; Eizirik D L; Svensson C; Strandell E; Welsh M; Welsh N
[Are cytokines mediators in the development of insulin-dependent diabetes mellitus?]
Läkartidningen 1992;89(20):1777-9.
1992: Borg L A; Cagliero E; Sandler S; Welsh N; Eizirik D L
Interleukin-1 beta increases the activity of superoxide dismutase in rat pancreatic islets.
Endocrinology 1992;130(5):2851-7.
1992: Eizirik D L; Tracey D E; Bendtzen K; Sandler S
Role of receptor binding and gene transcription for both the stimulatory and inhibitory effects of interleukin-1 in pancreatic beta-cells.
Autoimmunity 1992;12(2):127-33.
1991: Welsh N; Eizirik D L; Bendtzen K; Sandler S
Interleukin-1 beta-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase.
Endocrinology 1991;129(6):3167-73.
1991: Margulis B A; Sandler S; Eizirik D L; Welsh N; Welsh M
Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1 beta-induced impaired beta-cell function.
Diabetes 1991;40(11):1418-22.
1991: Eizirik D L; Sandler S; Ahnström G; Welsh M
Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induces long-lasting functional impairment of B-cells.
Biochemical pharmacology 1991;42(12):2275-82.
1991: Korsgren O; Jansson L; Eizirik D; Andersson A
Functional and morphological differentiation of fetal porcine islet-like cell clusters after transplantation into nude mice.
Diabetologia 1991;34(6):379-86.
1991: Eizirik D L; Tracey D E; Bendtzen K; Sandler S
An interleukin-1 receptor antagonist protein protects insulin-producing beta cells against suppressive effects of interleukin-1 beta.
Diabetologia 1991;34(6):445-8.
1991: Eizirik D L; Bendtzen K; Sandler S
Short exposure of rat pancreatic islets to interleukin-1 beta induces a sustained but reversible impairment in beta-cell function: influence of protease activation, gene transcription, and protein synthesis.
Endocrinology 1991;128(3):1611-6.
1991: Eizirik D L; Strandell E; Sandler S
Prolonged exposure of pancreatic islets isolated from "pre-diabetic" non-obese diabetic mice to a high glucose concentration does not impair beta-cell function.
Diabetologia 1991;34(1):6-11.
1991: Hellerström C; Eizirik D L; Welsh N; Sjöholm A; Jansson L; Svensson C; Strandell E; Korsgren O; Li Z Q; Andersson A
New perspectives on the structure and function of the normal and diabetic beta-cell.
Upsala journal of medical sciences 1991;96(1):1-16.
1991: Sandler S; Eizirik D L; Svensson C; Strandell E; Welsh M; Welsh N
Biochemical and molecular actions of interleukin-1 on pancreatic beta-cells.
Autoimmunity 1991;10(3):241-53.
1991: Eizirik D L
Interleukin-1 beta induces an early decrease in insulin release, (pro)insulin biosynthesis and insulin mRNA in mouse pancreatic islets by a mechanism dependent on gene transcription and protein synthesis.
Autoimmunity 1991;10(2):107-13.
1991: Welsh N; Welsh M; Lindquist S; Eizirik D L; Bendtzen K; Sandler S
Interleukin-1 beta increases the biosynthesis of the heat shock protein hsp70 and selectively decreases the biosynthesis of five proteins in rat pancreatic islets.
Autoimmunity 1991;9(1):33-40.
1990: Borg L A; Eizirik D L
Short-term exposure of rat pancreatic islets to human interleukin-1 beta increases cellular uptake of calcium.
Immunology letters 1990;26(3):253-8.
1990: Sandler S; Bendtzen K; Eizirik D L; Strandell E; Welsh M; Welsh N
Metabolism and beta-cell function of rat pancreatic islets exposed to human interleukin-1 beta in the presence of a high glucose concentration.
Immunology letters 1990;26(3):245-51.
1990: Eizirik D L; Welsh M; Strandell E; Welsh N; Sandler S
Interleukin-1 beta depletes insulin messenger ribonucleic acid and increases the heat shock protein hsp70 in mouse pancreatic islets without impairing the glucose metabolism.
Endocrinology 1990;127(5):2290-7.
1990: Strandell E; Eizirik D L; Sandler S
Reversal of beta-cell suppression in vitro in pancreatic islets isolated from nonobese diabetic mice during the phase preceding insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1990;85(6):1944-50.
1990: Sandler S; Bendtzen K; Eizirik D L; Welsh M
Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitro.
Endocrinology 1990;126(2):1288-94.
1989: Eizirik D L; Sandler S; Korsgren O; Jansson L; Andersson A
Persistent impairment of the insulin response to glucose both in vivo and in vitro after streptozotocin exposure: studies with grafted pancreatic islets and islets maintained in culture.
Acta endocrinologica 1989;121(6):849-56.
1989: Eizirik D L; Sandler S
Human interleukin-1 beta induced stimulation of insulin release from rat pancreatic islets is accompanied by an increase in mitochondrial oxidative events.
Diabetologia 1989;32(11):769-73.
1989: Sandler S; Bendtzen K; Eizirik D L; Sjöholm A; Welsh N
Decreased cell replication and polyamine content in insulin-producing cells after exposure to human interleukin 1 beta.
Immunology letters 1989;22(4):267-72.
1989: Eizirik D L; Sandler S
Sustained exposure of toxically damaged mouse pancreatic islets to high glucose does not increase beta-cell dysfunction.
The Journal of endocrinology 1989;123(1):47-51.
1989: Eizirik D L; Sandler S
Function and metabolism of pancreatic beta-cells maintained in culture following experimentally induced damage.
Pharmacology & toxicology 1989;65(3):163-8.
1989: Eizirik D L; Sandler S; Hallberg A; Bendtzen K; Sener A; Malaisse W J
Differential sensitivity to beta-cell secretagogues in cultured rat pancreatic islets exposed to human interleukin-1 beta.
Endocrinology 1989;125(2):752-9.
1989: Strandell E; Eizirik D L; Sandler S
Survival and B-cell function of mouse pancreatic islets maintained in culture after concomitant exposure to streptozotocin and nicotinamide.
Experimental and clinical endocrinology 1989;93(2-3):219-24.
1989: Sandler S; Bendtzen K; Borg L A; Eizirik D L; Strandell E; Welsh N
Studies on the mechanisms causing inhibition of insulin secretion in rat pancreatic islets exposed to human interleukin-1 beta indicate a perturbation in the mitochondrial function.
Endocrinology 1989;124(3):1492-501.
1988: Eizirik D L; Sandler S
Functional restoration of cultured mouse pancreatic islets after in vitro exposure to alloxan.
Pharmacology & toxicology 1988;63(5):396-9.
1988: Eizirik D L
Interleukin-1 induced impairment in pancreatic islet oxidative metabolism of glucose is potentiated by tumor necrosis factor.
Acta endocrinologica 1988;119(3):321-5.
1988: Strandell E; Eizirik D L; Korsgren O; Sandler S
Functional characteristics of cultured mouse pancreatic islets following exposure to different streptozotocin concentrations.
Molecular and cellular endocrinology 1988;59(1-2):83-91.
1988: Eizirik D L; Sandler S; Sener A; Malaisse W J
Defective catabolism of D-glucose and L-glutamine in mouse pancreatic islets maintained in culture after streptozotocin exposure.
Endocrinology 1988;123(2):1001-7.
1988: Eizirik D L; Strandell E; Bendtzen K; Sandler S
Functional characteristics of rat pancreatic islets maintained in culture after exposure to human interleukin 1.
Diabetes 1988;37(7):916-9.
1988: Welsh M; Eizirik D L; Strandell E
Heat-shock treatment of mouse pancreatic islets results in a partial loss of islet cells but no remaining functional impairment among the surviving beta cells.
Journal of molecular endocrinology 1988;1(1):27-31.
1988: Eizirik D L; Sandler S; Welsh N; Hellerström C
Preferential reduction of insulin production in mouse pancreatic islets maintained in culture after streptozotocin exposure.
Endocrinology 1988;122(4):1242-9.
1988: Eizirik D L; Strandell E; Sandler S
Culture of mouse pancreatic islets in different glucose concentrations modifies B cell sensitivity to streptozotocin.
Diabetologia 1988;31(3):168-74.
1987: Eizirik D L; Sandler S
The partial protective effect of branched chain amino acids against streptozotocin-induced cytotoxicity to mouse pancreatic islets in vitro.
Pharmacology & toxicology 1987;61(5):320-4.

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