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Ali El-Armouche

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Stefan Neef; Laetitia Pereira; Can M Sag; Johannes Backs; Henrik Bäumer; Donald M Bers; Maria Daut; Jaime DeSantiago; Ali El-Armouche; Clemens Grefe; Lars S Maier
While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIIδ-KO mice.
Anke Renger; Krasimira Sharkova; Maria-Patapia Zafiriou; Alexander Becker; Martin W Bergmann; Ali El-Armouche; Claudia Noack; Elena Pavlova; Wolfram-Hubertus Zimmermann; Laura C Zelarayán
The Four and a Half LIM-Domain 2 Controls Early Cardiac Cell Commitment and Expansion Via Regulating β-Catenin-Dependent Transcription.
M Dewenter; C Vettel; Ali El-Armouche
[Losmapimod: a novel drug against cardiovascular diseases?].

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2013: Stefan Neef; Laetitia Pereira; Can M Sag; Johannes Backs; Henrik Bäumer; Donald M Bers; Maria Daut; Jaime DeSantiago; Ali El-Armouche; Clemens Grefe; Lars S Maier
While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIIδ-KO mice.
Journal of molecular and cellular cardiology 2013;59():107-16.
2013: Anke Renger; Krasimira Sharkova; Maria-Patapia Zafiriou; Alexander Becker; Martin W Bergmann; Ali El-Armouche; Claudia Noack; Elena Pavlova; Wolfram-Hubertus Zimmermann; Laura C Zelarayán
The Four and a Half LIM-Domain 2 Controls Early Cardiac Cell Commitment and Expansion Via Regulating β-Catenin-Dependent Transcription.
Stem cells (Dayton, Ohio) 2013;31(5):928-40.
2013: M Dewenter; C Vettel; Ali El-Armouche
[Losmapimod: a novel drug against cardiovascular diseases?].
Deutsche medizinische Wochenschrift (1946) 2013;138(1-2):39-42.
2012: Christiane Vettel; Andreas Vogt; Ali El-Armouche; Susanne Lutz; Karola Wittig; Christina M Wuertz; Thomas Wieland
A novel player in cellular hypertrophy: Giβγ/PI3K-dependent activation of the RacGEF TIAM-1 is required for α₁-adrenoceptor induced hypertrophy in neonatal rat cardiomyocytes.
Journal of molecular and cellular cardiology 2012;53(2):165-75.
2012: P Christalla; M Dewenter; Ali El-Armouche
[Effectiveness and safety of varenicline for smoking cessation].
Deutsche medizinische Wochenschrift (1946) 2012;137(18):940-4.
2012: Bernhard Unsöld; Ali El-Armouche; Julius Emons; Kaomei Guan; Claudius Jacobshagen; Stefanie Klede; Ralph Knöll; Harald Kögler; Wolfgang A Linke; Hanna Schotola; Tim Seidler; Samuel Sossalla; Gerd Hasenfuss
Age-dependent changes in contractile function and passive elastic properties of myocardium from mice lacking muscle LIM protein (MLP).
European journal of heart failure 2012;14(4):430-7.
2012: Marion Hölscher; Dörthe M Katschinski; Sabine Krull; Yun Lin; Lars S Maier; Bernd J Pichler; Katrin Schäfer; Monique Silter; Patricia Thistlethwaite; Ali El-Armouche; Katja Farhat; Amke Hesse; Anke Zieseniss
Unfavourable consequences of chronic cardiac HIF-1α stabilization.
Cardiovascular research 2012;94(1):77-86.
2011: Ali El-Armouche; William Fuller; Jacqueline Howie; Michael J Shattock; Katrin Wittköpper; Davor Pavlovic
Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(12):4467-75.
2011: Malte Tiburcy; Xiaoke Yin; Anke Zieseniss; Oliver Boy; Peter Christalla; Michael Didié; Stephan Döker; Ali El-Armouche; Thomas Eschenhagen; Michael Grimm; Nazha Hamdani; Bijoy Chandapillai Karikkineth; Doerthe M Katschinksi; Wolfgang A Linke; Manuel Mayr; Hiroshi Naito; Monika Nose; Wolfram-Hubertus Zimmermann
Terminal differentiation, advanced organotypic maturation, and modeling of hypertrophic growth in engineered heart tissue.
Circulation research 2011;109(10):1105-14.
2011: Ali El-Armouche; Thomas Eschenhagen; Noriyuki Ouchi; Thomas Schulze; Komei Tanaka; Kenneth Walsh; Katrin Wittköpper; Gheorghe Doros; Flora Sam
Follistatin-like 1 in chronic systolic heart failure: a marker of left ventricular remodeling.
Circulation. Heart failure 2011;4(5):621-7.
2011: Katrin Wittköpper; Thomas Eschenhagen; Dobromir Dobrev; Ali El-Armouche
Phosphatase-1 inhibitor-1 in physiological and pathological β-adrenoceptor signalling.
Cardiovascular research 2011;91(3):392-401.
2011: K Wittköpper; J Emons; Ali El-Armouche
[Febuxostat].
Deutsche medizinische Wochenschrift (1946) 2011;136(23):1270-4.
2011: Yukiomi Tsuji; Mayumi Hojo; Niels Voigt; Ali El-Armouche; Yasuya Inden; Toyoaki Murohara; Dobromir Dobrev; Stanley Nattel; Itsuo Kodama; Kaichiro Kamiya
Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm.
Circulation 2011;123(20):2192-203.
2010: Ali El-Armouche; Azadeh Wahab; Katrin Wittköpper; Thomas Schulze; Felix Böttcher; Lutz Pohlmann; S Bruce King; Jenna F DuMond; Christian Gerloff; Rainer H Böger; Thomas Eschenhagen; Lucie Carrier; Sonia Donzelli
The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and β-adrenergically desensitized ventricular myocytes.
Biochemical and biophysical research communications 2010;402(2):340-4.
2010: Samuel Sossalla; Nina Fluschnik; Hanna Schotola; Katharina R Ort; Stefan Neef; Timo Schulte; Katrin Wittköpper; André Renner; Jan Schmitto; Jan Gummert; Ali El-Armouche; Gerd Hasenfuss; Lars S Maier
Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium.
Circulation research 2010;107(9):1150-61.
2010: Katrin Wittköpper; Thomas Eschenhagen; Ali El-Armouche
Phosphatase-1-inhibitor-1: amplifier or attenuator of catecholaminergic stress?
Basic research in cardiology 2010;105(5):569-71.
2010: Katrin Wittköpper; Larissa Fabritz; Stefan Neef; Katharina R Ort; Clemens Grefe; Bernhard Unsöld; Paulus Kirchhof; Lars S Maier; Gerd Hasenfuss; Dobromir Dobrev; Thomas Eschenhagen; Ali El-Armouche
Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging.
The Journal of clinical investigation 2010;120(2):617-26.
2010: Ali El-Armouche; Alexander Peter Schwoerer; Christiane Neuber; Julius Emmons; Daniel Biermann; Thomas Christalla; Adam Grundhoff; Thomas Eschenhagen; Wolfram-Hubertus Zimmermann; Julius Emons; Heimo Ehmke
Common microRNA signatures in cardiac hypertrophic and atrophic remodeling induced by changes in hemodynamic load.
PloS one 2010;5(12):e14263.
2009: Ali El-Armouche; Thomas Eschenhagen
Beta-adrenergic stimulation and myocardial function in the failing heart.
Heart failure reviews 2009;14(4):225-41.
2009: Dirk J Duncker; Nicky M Boontje; Dirk Duncker; Amanda Versteilen; Judith Krysiak; Giulia Mearini; Ali El-Armouche; Vincent de Beer; Jos M J Lamers; Lucie Carrier; Lori A Walker; Wolfgang A Linke; Ger J M Stienen; Jolanda van der Velden
Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling.
Circulation. Heart failure 2009;2(3):233-42.
2009: Ariane Schmechel; Michael Grimm; Ali El-Armouche; Grit Höppner; Alexander Peter Schwoerer; Heimo Ehmke; Thomas Eschenhagen
Treatment with atorvastatin partially protects the rat heart from harmful catecholamine effects.
Cardiovascular research 2009;82(1):100-6.
2009: Maura Greiser; Hans-Ruprecht Neuberger; Erik Harks; Ali El-Armouche; Peter Boknik; Sunniva de Haan; Fons Verheyen; Sander Verheule; Wilhelm Schmitz; Ursula Ravens; Stanley Nattel; Maurits A Allessie; Dobromir Dobrev; Ulrich Schotten
Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation.
Journal of molecular and cellular cardiology 2009;46(3):385-94.
2008: Alexander Peter Schwoerer; Christiane Neuber; Ariane Schmechel; Ivan Melnychenko; Giulia Mearini; Peter Boknik; Uwe Kirchhefer; Wilhelm Schmitz; Heimo Ehmke; Thomas Eschenhagen; Ali El-Armouche
Mechanical unloading of the rat heart involves marked changes in the protein kinase-phosphatase balance.
Journal of molecular and cellular cardiology 2008;45(6):846-52.
2008: Ali El-Armouche; Katrin Wittköpper; Franziska Degenhardt; Florian Weinberger; Michael Didié; Ivan Melnychenko; Michael Grimm; Micha Peeck; Wolfram-Hubertus Zimmermann; Bernhard Unsöld; Gerd Hasenfuss; Dobromir Dobrev; Thomas Eschenhagen
Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy.
Cardiovascular research 2008;80(3):396-406.
2008: Alexander Peter Schwoerer; Ivan Melnychenko; Diane Goltz; Nils Hedinger; Irene Broichhausen; Ali El-Armouche; Thomas Eschenhagen; Tilmann Volk; Heimo Ehmke
Unloaded rat hearts in vivo express a hypertrophic phenotype of cardiac repolarization.
Journal of molecular and cellular cardiology 2008;45(5):633-41.
2008: K Wittköpper; Ali El-Armouche; Thomas Eschenhagen
[Olanzapine].
Deutsche medizinische Wochenschrift (1946) 2008;133(39):1958-62.
2008: Stephanie Grote-Wessels; Hideo A Baba; Peter Boknik; Ali El-Armouche; Larissa Fabritz; Hans-Jörg Gillmann; Dana Kucerova; Marek Matus; Frank U Müller; Joachim Neumann; Martina Schmitz; Frank Stümpel; Gregor Theilmeier; Jeremias Wohlschlaeger; Wilhelm Schmitz; Uwe Kirchhefer
Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload.
Cardiovascular research 2008;79(3):464-71.
2008: Yin Hua Zhang; Mei Hua Zhang; Claire E Sears; Krzysztof Emanuel; Charles Redwood; Ali El-Armouche; Evangelia G Kranias; Barbara Casadei
Reduced phospholamban phosphorylation is associated with impaired relaxation in left ventricular myocytes from neuronal NO synthase-deficient mice.
Circulation research 2008;102(2):242-9.
2007: Ali El-Armouche; Thomas Eschenhagen
[Dopamine: less important in emergency medicine?].
Deutsche medizinische Wochenschrift (1946) 2007;132(49):2654.
2007: Ali El-Armouche; Fabian Gocht; Elmar Jaeckel; Katrin Wittköpper; Micha Peeck; Thomas Eschenhagen
Long-term beta-adrenergic stimulation leads to downregulation of protein phosphatase inhibitor-1 in the heart.
European journal of heart failure 2007;9(11):1077-80.
2007: Lutz Pohlmann; Irena Kröger; Nicolas Vignier; Saskia Schlossarek; Elisabeth Krämer; Catherine Coirault; Karim R Sultan; Ali El-Armouche; Saul Winegrad; Thomas Eschenhagen; Lucie Carrier
Cardiac myosin-binding protein C is required for complete relaxation in intact myocytes.
Circulation research 2007;101(9):928-38.
2007: Ali El-Armouche; Jasmin Singh; Hiroshi Naito; Katrin Wittköpper; Michael Didié; Alexander Laatsch; Wolfram-Hubertus Zimmermann; Thomas Eschenhagen
Adenovirus-delivered short hairpin RNA targeting PKCalpha improves contractile function in reconstituted heart tissue.
Journal of molecular and cellular cardiology 2007;43(3):371-6.
2007: Ali El-Armouche; Lutz Pohlmann; Saskia Schlossarek; Jutta Starbatty; Yung-Hsin Yeh; Stanley Nattel; Dobromir Dobrev; Thomas Eschenhagen; Lucie Carrier
Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure.
Journal of molecular and cellular cardiology 2007;43(2):223-9.
2007: Michael Grimm; Ali El-Armouche; Rong Zhang; Mark E Anderson; Thomas Eschenhagen
Reduced contractile response to alpha1-adrenergic stimulation in atria from mice with chronic cardiac calmodulin kinase II inhibition.
Journal of molecular and cellular cardiology 2007;42(3):643-52.
2006: Bogachan Sahin; Hongjun Shu; Joseph Fernandez; Ali El-Armouche; Jeffery D Molkentin; Angus Nairn; James A Bibb
Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C.
The Journal of biological chemistry 2006;281(34):24322-35.
2006: Ali El-Armouche; Peter Boknik; Thomas Eschenhagen; Lucie Carrier; Michael Knaut; Ursula Ravens; Dobromir Dobrev
Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation.
Circulation 2006;114(7):670-80.
2006: Ali El-Armouche; Anna Bednorz; Torsten Pamminger; Diana Ditz; Michael Didié; Dobromir Dobrev; Thomas Eschenhagen
Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes.
Biochemical and biophysical research communications 2006;346(3):700-6.
2006: Michael Grimm; Nina Mahnecke; Friederike Soja; Ali El-Armouche; Pascal Haas; Hendrik Treede; Hermann Reichenspurner; Thomas Eschenhagen
The MLCK-mediated alpha1-adrenergic inotropic effect in atrial myocardium is negatively modulated by PKCepsilon signaling.
British journal of pharmacology 2006;148(7):991-1000.
2004: Ali El-Armouche; Elmar Jaeckel; Kenneth R Boheler; Peter Boknik; Boris Hertle; Joachim Neumann; Thomas Eschenhagen
Ouabain treatment is associated with upregulation of phosphatase inhibitor-1 and Na+/Ca(2+)-exchanger and beta-adrenergic sensitization in rat hearts.
Biochemical and biophysical research communications 2004;318(1):219-26.
2004: Ali El-Armouche; Torsten Pamminger; Diana Ditz; Oliver Zolk; Thomas Eschenhagen
Decreased protein and phosphorylation level of the protein phosphatase inhibitor-1 in failing human hearts.
Cardiovascular research 2004;61(1):87-93.
2003: Ali El-Armouche; Oliver Zolk; Thomas Rau; Thomas Eschenhagen
Inhibitory G-proteins and their role in desensitization of the adenylyl cyclase pathway in heart failure.
Cardiovascular research 2003;60(3):478-87.
2003: Ali El-Armouche; Oliver Zolk; Thomas Eschenhagen
[Citalopram].
Deutsche medizinische Wochenschrift (1946) 2003;128(43):2253-6.
2003: Oliver Zolk; Michael Marx; Elmar Jäckel; Ali El-Armouche; Thomas Eschenhagen
Beta-adrenergic stimulation induces cardiac ankyrin repeat protein expression: involvement of protein kinase A and calmodulin-dependent kinase.
Cardiovascular research 2003;59(3):563-72.
2003: S Wiechert; Ali El-Armouche; Thomas Rau; Wolfram-Hubertus Zimmermann; Thomas Eschenhagen
24-h Langendorff-perfused neonatal rat heart used to study the impact of adenoviral gene transfer.
American journal of physiology. Heart and circulatory physiology 2003;285(2):H907-14.
2003: Ali El-Armouche; Thomas Rau; Oliver Zolk; Diana Ditz; Torsten Pamminger; Wolfram-Hubertus Zimmermann; Elmar Jäckel; Sian E Harding; Peter Boknik; Joachim Neumann; Thomas Eschenhagen
Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(3):437-9.
2002: Oliver Zolk; Jessika Quattek; Ute Seeland; Ali El-Armouche; Thomas Eschenhagen; Michael Böhm
Activation of the cardiac endothelin system in left ventricular hypertrophy before onset of heart failure in TG(mREN2)27 rats.
Cardiovascular research 2002;53(2):363-71.
2001: Oliver Zolk; Ali El-Armouche; Thomas Eschenhagen
[Drug interactions in the practice. Which combinations are taboo?].
MMW Fortschritte der Medizin 2001;143(51-52):24-32.