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Mohamed El Ayeb

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Lamia Borchani; Haifa Ben Gharsa; Zakaria Ben Lasfar; Ines Safra; Atfa Sassi; Delavar Shahbazzadeh; Mohamed El Ayeb
The pathological effects of Heminecrolysin, a dermonecrotic toxin from Hemiscorpius lepturus scorpion venom are mediated through its lysophospholipase D activity.
Raoudha Zouari-Kessentini; Najet Srairi-Abid; Amine Bazaa; Mohamed El Ayeb; Jose Luis; Naziha Marrakchi
Antitumoral potential of Tunisian snake venoms secreted phospholipases A2.
Maram Morjen; Houcemeddine Othman; Libia Sanz; Najet Srairi-Abid; Raoudha Zouari-Kessentini; Amine Bazaa; Juan José Calvete; Mohamed El Ayeb; Olfa Kallech-Ziri; José Luis; Kamel Mabrouk; Naziha Marrakchi
PIVL, a new serine protease inhibitor from Macrovipera lebetina transmediterranea venom, impairs motility of human glioblastoma cells.

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All Publications

2013: Lamia Borchani; Haifa Ben Gharsa; Zakaria Ben Lasfar; Ines Safra; Atfa Sassi; Delavar Shahbazzadeh; Mohamed El Ayeb
The pathological effects of Heminecrolysin, a dermonecrotic toxin from Hemiscorpius lepturus scorpion venom are mediated through its lysophospholipase D activity.
Toxicon : official journal of the International Society on Toxinology 2013;68():30-9.
2013: Raoudha Zouari-Kessentini; Najet Srairi-Abid; Amine Bazaa; Mohamed El Ayeb; Jose Luis; Naziha Marrakchi
Antitumoral potential of Tunisian snake venoms secreted phospholipases A2.
BioMed research international 2013;2013():391389.
2013: Maram Morjen; Houcemeddine Othman; Libia Sanz; Najet Srairi-Abid; Raoudha Zouari-Kessentini; Amine Bazaa; Juan José Calvete; Mohamed El Ayeb; Olfa Kallech-Ziri; José Luis; Kamel Mabrouk; Naziha Marrakchi
PIVL, a new serine protease inhibitor from Macrovipera lebetina transmediterranea venom, impairs motility of human glioblastoma cells.
Matrix biology : journal of the International Society for Matrix Biology 2013;32(1):52-62.
2012: Jed Jebali; José Luis; Naziha Marrakchi; Sylvie Mathieu; Maram Morjen; Amine Bazaa; Mohamed El Ayeb; Ali Gargouri; Charlotte Jeanneau; Assou El-Battari
Expression of a functional recombinant C-type lectin-like protein lebecetin in the human embryonic kidney cells.
Biotechnology progress 2012;28(6):1560-5.
2012: Issam Hmila; Serge Muyldermans; Bram Roosens; Hayfa Tounsi; Rahma Ben Abderrazek; Samir Boubaker; Balkiss Bouhaouala-Zahar; Vicky Caveliers; Bernard Cosyns; Mohamed El Ayeb; Tony Lahoutte
Pre-clinical studies of toxin-specific nanobodies: evidence of in vivo efficacy to prevent fatal disturbances provoked by scorpion envenoming.
Toxicology and applied pharmacology 2012;264(2):222-31.
2012: Mojgan Heidarpour; Ghader Khalili; Najet Srairi-Abid; Hamed Ahari; Hossein Amini; Amir Ali Anvar; Lamia Borchani; Samir Boubaker; Mohamed El Ayeb; Emna Ennaifer; Delavar Shahbazzadeh
Histopathological changes induced by Hemiscorpius lepturus scorpion venom in mice.
Toxicon : official journal of the International Society on Toxinology 2012;59(3):373-8.
2011: Lamia Borchani; Ines Safra; Atfa Sassi; Ramla Ben Yekhlef; Mohamed El Ayeb
Heminecrolysin, a potential immunogen for monospecific antivenom production against Hemiscorpius lepturus scorpion.
Toxicon : official journal of the International Society on Toxinology 2011;58(8):681-8.
2011: Balkiss Bouhaouala-Zahar; Naima Abidi; Rahma Ben Abderrazek; Issam Hmila; Serge Muyldermans; Mohamed El Ayeb
Immunological aspects of scorpion toxins: current status and perspectives.
Inflammation & allergy drug targets 2011;10(5):358-68.
2011: Rahma Ben Abderrazek; Naima Abidi; Mohamed El Ayeb; Issam Hmila; Serge Muyldermans; Dirk Saerens; Cécile Vincke; Balkiss Bouhaouala-Zahar
Development of Cys38 knock-out and humanized version of NbAahII10 nanobody with improved neutralization of AahII scorpion toxin.
Protein engineering, design & selection : PEDS 2011;24(9):727-35.
2011: Lamia Borchani; Mohamed Samir Boubaker; Abolfazl Akbari; Atfa Sassi; Delavar Shahbazzadeh; Jean-Marc Strub; Haïfa Tounsi-Guetteti; Alain Van Dorsselaer; Mohamed El Ayeb
Heminecrolysin, the first hemolytic dermonecrotic toxin purified from scorpion venom.
Toxicon : official journal of the International Society on Toxinology 2011;58(1):130-9.
2011: J Jebali; José Luis; S Mathieu; Amine Bazaa; Mohamed El Ayeb; Assou El-Battari; C Jeanneau; Naziha Marrakchi
[Selectins as adhesion molecules and potential therapeutic target].
Archives de l'Institut Pasteur de Tunis 2011;88(1-4):3-18.
2010: Issam Hmila; Dirk Saerens; Rahma Ben Abderrazek; Cécile Vincke; Naima Abidi; Zakaria Benlasfar; Jochen Govaert; Mohamed El Ayeb; Balkiss Bouhaouala-Zahar; Serge Muyldermans
A bispecific nanobody to provide full protection against lethal scorpion envenoming.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(9):3479-89.
2010: Inès Limam; Amine Bazaa; Najet Srairi-Abid; Salma Taboubi; Jed Jebali; Raoudha Zouari-Kessentini; Olfa Kallech-Ziri; Hafedh Mejdoub; Asma Hammami; Mohamed El Ayeb; José Luis; Naziha Marrakchi
Leberagin-C, A disintegrin-like/cysteine-rich protein from Macrovipera lebetina transmediterranea venom, inhibits alphavbeta3 integrin-mediated cell adhesion.
Matrix biology : journal of the International Society for Matrix Biology 2010;29(2):117-26.
2010: I Limam; Mohamed El Ayeb; Naziha Marrakchi
[Snake venom metalloproteinases: structure, biosynthesis and function(s)].
Archives de l'Institut Pasteur de Tunis 2010;87(1-2):3-15.
2010: Amine Bazaa; Eddy Pasquier; Céline Defilles; Ines Limam; Raoudha Kessentini-Zouari; Olfa Kallech-Ziri; Assou El-Battari; Diane Braguer; Mohamed El Ayeb; Naziha Marrakchi; José Luis
MVL-PLA2, a snake venom phospholipase A2, inhibits angiogenesis through an increase in microtubule dynamics and disorganization of focal adhesions.
PloS one 2010;5(4):e10124.
2009: Rahma Ben Abderrazek; Issam Hmila; Cécile Vincke; Zakaria Benlasfar; Mireille Pellis; Hafedh Dabbek; Dirk Saerens; Mohamed El Ayeb; Serge Muyldermans; Balkiss Bouhaouala-Zahar
Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom.
The Biochemical journal 2009;424(2):263-72.
2009: Amine Bazaa; José Luis; Najet Srairi-Abid; Olfa Kallech-Ziri; Raoudha Kessentini-Zouari; Céline Defilles; Jean-Claude Lissitzky; Mohamed El Ayeb; Naziha Marrakchi
MVL-PLA2, a phospholipase A2 from Macrovipera lebetina transmediterranea venom, inhibits tumor cells adhesion and migration.
Matrix biology : journal of the International Society for Matrix Biology 2009;28(4):188-93.
2009: Raoudha Zouari-Kessentini; José Luis; Aida Karray; Olfa Kallech-Ziri; Najet Srairi-Abid; Amine Bazaa; Erwann Loret; Laboratoire Biochimie et Genie Enzymatique des Lipases; Mohamed El Ayeb; Naziha Marrakchi
Two purified and characterized phospholipases A2 from Cerastes cerastes venom, that inhibit cancerous cell adhesion and migration.
Toxicon : official journal of the International Society on Toxinology 2009;53(4):444-53.
2009: Jed Jebali; Amine Bazaa; Sameh Sarray; Khemais Benhaj; Anis Karboul; Mohamed El Ayeb; Naziha Marrakchi; Ali Gargouri
C-type lectin protein isoforms of Macrovipera lebetina: cDNA cloning and genetic diversity.
Toxicon : official journal of the International Society on Toxinology 2009;53(2):228-37.
2009: Rima Soli; Belhassen Kaabi; Mourad Barhoumi; Mohamed El Ayeb; Najet Srairi-Abid
Bioinformatic characterizations and prediction of K+ and Na+ ion channels effector toxins.
BMC pharmacology 2009;9():4.
2008: Najet Srairi-Abid; Delavar Shahbazzadeh; Imen Chatti; Saoussen Mlayah-Bellalouna; Hafedh Mejdoub; Lamia Borchani; Rym Benkhalifa; Abolfazl Akbari; Mohamed El Ayeb
Hemitoxin, the first potassium channel toxin from the venom of the Iranian scorpion Hemiscorpius lepturus.
The FEBS journal 2008;275(18):4641-50.
2008: Najet Srairi-Abid; H Kaabi; Saoussen Mlayah-Bellalouna; Thouraya Mejri; François Sampieri; Mohamed El Ayeb
Immunological characterization of a non-toxic peptide conferring protection against the toxic fraction (AahG50) of the Androctonus australis hector venom.
Toxicon : official journal of the International Society on Toxinology 2008;51(3):353-62.
2008: Sameh Sarray; José Luis; Mohamed El Ayeb; Naziha Marrakchi
[Snake venoms C-type lectins and their receptors on platelets and cancerous cells].
Archives de l'Institut Pasteur de Tunis 2008;85(1-4):69-80.
2007: Delavar Shahbazzadeh; Najet Srairi-Abid; Wei Feng; Narendra Ram; Lamia Borchani; Michel Ronjat; Abolfazl Akbari; Isaac N Pessah; Michel De Waard; Mohamed El Ayeb
Hemicalcin, a new toxin from the Iranian scorpion Hemiscorpius lepturus which is active on ryanodine-sensitive Ca2+ channels.
The Biochemical journal 2007;404(1):89-96.
2007: Anthony Pilorget; Magali Conesa; Sameh Sarray; Jonathan Michaud-Levesque; Salma Daoud; Kwang S Kim; Michel Demeule; Jacques Marvaldi; Mohamed El Ayeb; Naziha Marrakchi; Richard Béliveau; José Luis
Lebectin, a Macrovipera lebetina venom-derived C-type lectin, inhibits angiogenesis both in vitro and in vivo.
Journal of cellular physiology 2007;211(2):307-15.
2007: Sameh Sarray; Estelle Delamarre; Jacques Marvaldi; Mohamed El Ayeb; Naziha Marrakchi; José Luis
Lebectin and lebecetin, two C-type lectins from snake venom, inhibit alpha5beta1 and alphaV-containing integrins.
Matrix biology : journal of the International Society for Matrix Biology 2007;26(4):306-13.
2007: Amine Bazaa; Paula Juárez; Naziha Marrakchi; Zakaria Bel Lasfer; Mohamed El Ayeb; Robert A Harrison; Juan J Calvete; Libia Sanz
Loss of introns along the evolutionary diversification pathway of snake venom disintegrins evidenced by sequence analysis of genomic DNA from Macrovipera lebetina transmediterranea and Echis ocellatus.
Journal of molecular evolution 2007;64(2):261-71.
2007: Amani Cheikh; Christian Cognard; Daniel Potreau; J Bescond; Guy Raymond; Mohamed El Ayeb; Rym Benkhalifa
[Modulation of skeletal muscle contraction by the non-toxic fraction of Buthus occitanus tunetanus venom via the cholinergic receptors].
Archives de l'Institut Pasteur de Tunis 2007;84(1-4):39-47.
2007: O Kallech-Ziri; José Luis; Mohamed El Ayeb; Naziha Marrakchi
[Snake venom disintegrins: classification and therapeutic potential].
Archives de l'Institut Pasteur de Tunis 2007;84(1-4):29-37.
2007: Amani Cheikh; Rym Benkhalifa; Daniel Potreau; Guy Raymond; Mohamed El Ayeb; Christian Cognard
A novel depolarizing activity of scorpion venom fraction M1 due to activation of skeletal muscle nicotinic receptors.
Toxicon : official journal of the International Society on Toxinology 2007;49(1):117-22.
2006: Amani Cheikh; Rym Benkhalifa; Jocelyn Bescond; Mohamed El Ayeb; Guy Raymond; Christian Cognard; Daniel Potreau
Depression of cardiac L-type calcium current by a scorpion venom fraction M1 following muscarinic receptors interaction involving adenylate cyclase pathway.
Toxicon : official journal of the International Society on Toxinology 2006;48(4):373-87.
2006: Libia Sanz; Amine Bazaa; Naziha Marrakchi; Alicia Pérez; Mehdi Chenik; Zakaria Bel Lasfer; Mohamed El Ayeb; Juan J Calvete
Molecular cloning of disintegrins from Cerastes vipera and Macrovipera lebetina transmediterranea venom gland cDNA libraries: insight into the evolution of the snake venom integrin-inhibition system.
The Biochemical journal 2006;395(2):385-92.
2005: Rahima Bel Haj Rhouma; Martine Cérutti-Duonor; Khadija Benkhadir; Françoise Goudey-Perrière; Mohamed El Ayeb; Miguel Lopez-Ferber; Habib Karoui
Insecticidal effects of Buthus occitanus tunetanus BotIT6 toxin expressed in Escherichia coli and baculovirus/insect cells.
Journal of insect physiology 2005;51(12):1376-83.
2005: Amine Bazaa; Naziha Marrakchi; Mohamed El Ayeb; Libia Sanz; Juan J Calvete
Snake venomics: comparative analysis of the venom proteomes of the Tunisian snakes Cerastes cerastes, Cerastes vipera and Macrovipera lebetina.
Proteomics 2005;5(16):4223-35.
2005: Sarrah M'barek; Benjamin Chagot; nicolas andreotti; Violeta Visan; Pascal Mansuelle; Stephan Grissmer; Mohamed Marrakchi; Mohamed El Ayeb; François Sampieri; Hervé Darbon; Ziad Fajloun; Michel De Waard; Jean-Marc Sabatier
Increasing the molecular contacts between maurotoxin and Kv1.2 channel augments ligand affinity.
Proteins 2005;60(3):401-11.
2005: Najet Srairi-Abid; J Iñaki Guijarro; Rym Benkhalifa; Massimo Mantegazza; Amani Cheikh; Manel Ben Aissa; Pierre-Yves Haumont; Muriel DELEPIERRE; Mohamed El Ayeb
A new type of scorpion Na+-channel-toxin-like polypeptide active on K+ channels.
The Biochemical journal 2005;388(Pt 2):455-64.
2005: Lamia Ouanes Besbes; Souheil El Atrous; Semir Nouira; Nicolas Aubrey; Alain Carayon; Mohamed El Ayeb; Fekri Abroug
Direct vs. mediated effects of scorpion venom: an experimental study of the effects of a second challenge with scorpion venom.
Intensive care medicine 2005;31(3):441-6.
2005: Nejla Soudani; Jouda Gharbi-Chihi; Najet Srairi-Abid; Claire Martin-El Yazidi; Richard Planells; Alain Margotat; Janine Torresani; Mohamed El Ayeb
Isolation and molecular characterization of LVP1 lipolysis activating peptide from scorpion Buthus occitanus tunetanus.
Biochimica et biophysica acta 2005;1747(1):47-56.
2005: Mohamed Naceur Krifi; Sandrine Savin; Marcel Debray; Cassian Bon; Mohamed El Ayeb; Valérie Choumet
Pharmacokinetic studies of scorpion venom before and after antivenom immunotherapy.
Toxicon : official journal of the International Society on Toxinology 2005;45(2):187-98.
2005: N Soudani; J Gharbi-Chihi; Najet Srairi-Abid; H Kaabi; Alain Margotat; Janine Torresani; Mohamed El Ayeb
Identification of second lipolysis activating protein from scorpion Buthus occitanus tunetanus.
Archives de l'Institut Pasteur de Tunis 2005;82(1-4):39-46.
2004: Sarrah M'barek; Ziad Fajloun; Sandrine Cestèle; Christiane Devaux; Pascal Mansuelle; Amor Mosbah; Besma Jouirou; Massimo Mantegazza; Jurphaas van Rietschoten; Mohamed El Ayeb; Hervé Rochat; Jean-Marc Sabatier; François Sampieri
First chemical synthesis of a scorpion alpha-toxin affecting sodium channels: the Aah I toxin of Androctonus australis hector.
Journal of peptide science : an official publication of the European Peptide Society 2004;10(11):666-77.
2004: Christiane Devaux; Besma Jouirou; Mohamed Naceur Krifi; Olivier Clot-Faybesse; Mohamed El Ayeb; Hervé Rochat
Quantitative variability in the biodistribution and in toxinokinetic studies of the three main alpha toxins from the Androctonus australis hector scorpion venom.
Toxicon : official journal of the International Society on Toxinology 2004;43(6):661-9.
2004: Sameh Sarray; Virginie Berthet; Juan J Calvete; Jeannine Secchi; Jacques Marvaldi; Mohamed El Ayeb; Naziha Marrakchi; José Luis
Lebectin, a novel C-type lectin from Macrovipera lebetina venom, inhibits integrin-mediated adhesion, migration and invasion of human tumour cells.
Laboratory investigation; a journal of technical methods and pathology 2004;84(5):573-81.
2004: Basma Mahjoubi-Boubaker; Marcel Crest; Rym Ben Khalifa; Mohamed El Ayeb; Riadh Kharrat
Kbot1, a three disulfide bridges toxin from Buthus occitanus tunetanus venom highly active on both SK and Kv channels.
Peptides 2004;25(4):637-45.
2004: Khadija Benkhadir; Riadh Kharrat; Sandrine Cestèle; Amor Mosbah; Hervé Rochat; Mohamed El Ayeb; Habib Karoui
Molecular cloning and functional expression of the alpha-scorpion toxin BotIII: pivotal role of the C-terminal region for its interaction with voltage-dependent sodium channels.
Peptides 2004;25(2):151-61.
2004: Besma Jouirou; Amor Mosbah; Violeta Visan; Stephan Grissmer; Sarrah M'barek; Ziad Fajloun; Jurphaas van Rietschoten; Christiane Devaux; Hervé Rochat; Guy Lippens; Mohamed El Ayeb; Michel De Waard; Kamel Mabrouk; Jean-Marc Sabatier
Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels.
The Biochemical journal 2004;377(Pt 1):37-49.
2003: Fatma Meddeb-Mouelhi; Balkiss Bouhaouala-Zahar; Zakaria Benlasfar; Mohamed Hammadi; Thouraya Mejri; Mekki Moslah; Habib Karoui; Touhami Khorchani; Mohamed El Ayeb
Immunized camel sera and derived immunoglobulin subclasses neutralizing Androctonus australis hector scorpion toxins.
Toxicon : official journal of the International Society on Toxinology 2003;42(7):785-91.
2003: Fekri Abroug; Semir Nouira; Souheil El Atrous; Lamia Besbes; Riadh Boukef; Mohamed Boussarsar; Soudani Marghli; Joëlle Eurin; Christiane Barthelemy; Mohamed El Ayeb; Koussay Dellagi; Alain Carayon
A canine study of immunotherapy in scorpion envenomation.
Intensive care medicine 2003;29(12):2266-76.
2003: Sameh Sarray; Najet Srairi; Mohamed Hatmi; José Luis; Hechmi Louzir; Imed Regaya; Hmida Slema; Jacques Marvaldi; Mohamed El Ayeb; Naziha Marrakchi
Lebecetin, a potent antiplatelet C-type lectin from Macrovipera lebetina venom.
Biochimica et biophysica acta 2003;1651(1-2):30-40.
2003: Hafedh Dekhil; Anne Wisner; Naziha Marrakchi; Mohamed El Ayeb; Cassian Bon; Habib Karoui
Molecular cloning and expression of a functional snake venom serine proteinase, with platelet aggregating activity, from the Cerastes cerastes viper.
Biochemistry 2003;42(36):10609-18.
2003: Sarrah M'barek; Ignacio Lopez-Gonzalez; nicolas andreotti; eric di Luccio; Violeta Visan; Stephan Grissmer; Susan I V Judge; Mohamed El Ayeb; Hervé Darbon; Hervé Rochat; François Sampieri; Evelyne Béraud; Ziad Fajloun; Michel De Waard; Jean-Marc Sabatier
A maurotoxin with constrained standard disulfide bridging: innovative strategy of chemical synthesis, pharmacology, and docking on K+ channels.
The Journal of biological chemistry 2003;278(33):31095-104.
2003: Thouraya Mejri; Lamia Borchani; Najet Srairi-Abid; Rym Benkhalifa; Sandrine Cestele; Imed Regaya; Habib Karoui; Marcel Pelhate; Hervé Rochat; Mohamed El Ayeb
BotIT6: a potent depressant insect toxin from Buthus occitanus tunetanus venom.
Toxicon : official journal of the International Society on Toxinology 2003;41(2):163-71.
2003: B Mahjoubi-Boubaker; Mohamed El Ayeb; Riadh Kharrat
[Characterisation of a novel toxin active on potassium apanaine channels, purified from Buthus occitanus tunetanus scorpion venom].
Archives de l'Institut Pasteur de Tunis 2003;80(1-4):43-52.
2003: Rahima Bel Haj Rhouma; H Dkhil; Khadija Benkhadir; Lamia Borchani; Mohamed El Ayeb; Habib Karoui
Molecular cloning and nucleotide sequence analysis of encoded anti-insect toxin BotIT2 from the scorpion Buthus occitanus tunetanus venom.
Archives de l'Institut Pasteur de Tunis 2003;80(1-4):35-41.
2002: Balkiss Bouhaouala-Zahar; Rym Benkhalifa; Najet Srairi; Ilhem Zenouaki; Caroline Ligny-Lemaire; Pascal Drevet; François Sampieri; Marcel Pelhate; Mohamed El Ayeb; André Ménez; Habib Karoui; Frédéric Ducancel
A chimeric scorpion alpha-toxin displays de novo electrophysiological properties similar to those of alpha-like toxins.
European journal of biochemistry / FEBS 2002;269(12):2831-41.
2002: Khadija Benkhadir; Thouraya Mejri; Rahima Bel Haj Rhouma; Mohamed El Ayeb; Habib Karoui
[In vivo and in vitro protection against lethal activity of Buthus occitanus tunetanus venom with a recombinant protein].
Archives de l'Institut Pasteur de Tunis 2002;79(1-4):19-26.
2002: Naziha Marrakchi; Sameh Sarray; Jacques Marvaldi; Mohamed El Ayeb; José Luis
[Effect of Macrovipera lebetina and Cerastes cerastes venoms on adherence to integrins of cancerous cells (IGR39, HT29-D4 and IGROV1)].
Archives de l'Institut Pasteur de Tunis 2002;79(1-4):3-9.
2001: Christian Legros; H Kaabi; Mohamed El Ayeb; Brigitte Céard; Hélène Vacher; Pierre E Bougis; Marie-France Martin-Eauclaire
Use of fusion protein constructs to generate potent immunotherapy and protection against scorpion toxins.
Vaccine 2001;20(5-6):934-42.
2001: Mohamed Naceur Krifi; K Miled; M Abderrazek; Mohamed El Ayeb
Effects of antivenom on Buthus occitanus tunetanus (Bot) scorpion venom pharmacokinetics: towards an optimization of antivenom immunotherapy in a rabbit model.
Toxicon : official journal of the International Society on Toxinology 2001;39(9):1317-26.
2001: Ammar Gasmi; Najet Srairi; S Guermazi; Hafedh Dekhil; H Dkhil; Habib Karoui; Mohamed El Ayeb
Amino acid structure and characterization of a heterodimeric disintegrin from Vipera lebetina venom.
Biochimica et biophysica acta 2001;1547(1):51-6.
2001: Naziha Marrakchi; Kamel Mabrouk; Imed Regaya; Sameh Sarray; Mohamed Fathallah; Hervé Rochat; Mohamed El Ayeb
Lebetin peptides: potent platelet aggregation inhibitors.
Haemostasis 2001;31(3-6):207-10.
2001: Sameh Sarray; Najet Srairi; José Luis; Jacques Marvaldi; Mohamed El Ayeb; Naziha Marrakchi
Lebecetin, a C-lectin protein from the venom of Macrovipera lebetina that inhibits platelet aggregation and adhesion of cancerous cells.
Haemostasis 2001;31(3-6):173-6.
2001: H Kaabi; Riadh Kharrat; Mohamed El Ayeb
[Study of the protective capacity of scorpion venom Buthus occitanus tunetanus polymerised to glutaraldehyde in mice strains with different haplotypes].
Archives de l'Institut Pasteur de Tunis 2001;78(1-4):17-23.
2000: Najet Srairi-Abid; Pascal Mansuelle; Thouraya Mejri; Habib Karoui; Hervé Rochat; François Sampieri; Mohamed El Ayeb
Purification, characterization and molecular modelling of two toxin-like proteins from the Androctonus australis Hector venom.
European journal of biochemistry / FEBS 2000;267(17):5614-20.
2000: Ammar Gasmi; Najet Srairi; Habib Karoui; Mohamed El Ayeb
Amino acid sequence of VlF: identification in the C-terminal domain of residues common to non-hemorrhagic metalloproteinases from snake venoms.
Biochimica et biophysica acta 2000;1481(1):209-12.
2000: Amor Mosbah; Riadh Kharrat; Ziad Fajloun; Jean-Guillaume Renisio; E Blanc; Jean-Marc Sabatier; Mohamed El Ayeb; Hervé Darbon
A new fold in the scorpion toxin family, associated with an activity on a ryanodine-sensitive calcium channel.
Proteins 2000;40(3):436-42.
2000: Ziad Fajloun; Riadh Kharrat; L Chen; C Lecomte; eric di Luccio; Delphine Bichet; Mohamed El Ayeb; Hervé Rochat; P D Allen; I N Pessah; Michel De Waard; Jean-Marc Sabatier
Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca(2+) release channel/ryanodine receptors.
FEBS letters 2000;469(2-3):179-85.
2000: C Lecomte; R Ben Khalifa; Marie-France Martin-Eauclaire; Riadh Kharrat; Mohamed El Ayeb; Hervé Darbon; Hervé Rochat; Marcel Crest; Jean-Marc Sabatier
Maurotoxin and the Kv1.1 channel: voltage-dependent binding upon enantiomerization of the scorpion toxin disulfide bridge Cys31-Cys34.
The journal of peptide research : official journal of the American Peptide Society 2000;55(3):246-54.
1999: Mohamed Naceur Krifi; F Amri; H Kharrat; Mohamed El Ayeb
Evaluation of antivenom therapy in children severely envenomed by Androctonus australis garzonii (Aag) and Buthus occitanus tunetanus (Bot) scorpions.
Toxicon : official journal of the International Society on Toxinology 1999;37(11):1627-34.
1998: Mohamed Naceur Krifi; Naziha Marrakchi; Mohamed El Ayeb; Koussay Dellagi
Effect of some variables on the in vivo determination of scorpion and viper venom toxicities.
Biologicals : journal of the International Association of Biological Standardization 1998;26(4):277-88.
1998: Rym Barbouche; Naziha Marrakchi; Kamel Mabrouk; Mohamed Naceur Krifi; Jurphaas van Rietschoten; Emmanuel Fenouillet; Mohamed El Ayeb; Hervé Rochat
Anti-platelet activity of the peptides composing the lebetin 1 family, a new class of inhibitors of platelet aggregation.
Toxicon : official journal of the International Society on Toxinology 1998;36(12):1939-47.
1998: Hervé Rochat; Riadh Kharrat; Jean-Marc Sabatier; Pascal Mansuelle; Marcel Crest; Marie-France Martin-Eauclaire; François Sampieri; Razika Oughideni; Kamel Mabrouk; Guy Jacquet; Jurphaas van Rietschoten; Mohamed El Ayeb
Maurotoxin, a four disulfide bridges scorpion toxin acting on K+ channels.
Toxicon : official journal of the International Society on Toxinology 1998;36(11):1609-11.
1998: Mohamed Naceur Krifi; Mohamed El Ayeb
An equilibrium ELISA for the dosage of Androctonus australis garzonii (Aag) and Buthus occitanus tunetanus (Bot) scorpion venoms: set up and calibration.
Archives de l'Institut Pasteur de Tunis 1998;75(3-4):185-94.
1998: Mohamed Naceur Krifi; H Kharrat; K Zghal; M Abdouli; Fekri Abroug; Slah Bouchoucha; Koussay Dellagi; Mohamed El Ayeb
Development of an ELISA for the detection of scorpion venoms in sera of humans envenomed by Androctonus australis garzonii (Aag) and Buthus occitanus tunetanus (Bot): correlation with clinical severity of envenoming in Tunisia.
Toxicon : official journal of the International Society on Toxinology 1998;36(6):887-900.
1998: Naziha Marrakchi; Mohamed El Ayeb
[Thrombin-like serine proteases in Cerasted venoms (Cerasted cerastes and Cerastes vipera)].
Archives de l'Institut Pasteur de Tunis 1998;75(1-2):3-8.
1997: E Blanc; Jean-Marc Sabatier; Riadh Kharrat; S Meunier; Mohamed El Ayeb; Jurphaas van Rietschoten; Hervé Darbon
Solution structure of maurotoxin, a scorpion toxin from Scorpio maurus, with high affinity for voltage-gated potassium channels.
Proteins 1997;29(3):321-33.
1997: Naziha Marrakchi; Rym Barbouche; S Guermazi; Habib Karoui; Cassian Bon; Mohamed El Ayeb
Cerastotin, a serine protease from Cerastes cerastes venom, with platelet-aggregating and agglutinating properties.
European journal of biochemistry / FEBS 1997;247(1):121-8.
1997: Riadh Kharrat; Ilhem Zenouaki; Z Ben Lasfar; K Miled; Mohamed El Ayeb
Molecular characterization, antigenicity and immunogenicity of anatoxic polymeric forms conferring protection against scorpion venoms.
Toxicon : official journal of the International Society on Toxinology 1997;35(6):915-30.
1997: Riadh Kharrat; Pascal Mansuelle; François Sampieri; Marcel Crest; Razika Oughideni; Jurphaas van Rietschoten; Marie-France Martin-Eauclaire; Hervé Rochat; Mohamed El Ayeb
Maurotoxin, a four disulfide bridge toxin from Scorpio maurus venom: purification, structure and action on potassium channels.
FEBS letters 1997;406(3):284-90.
1997: Sandrine Cestèle; Lamia Borchani; Mohamed El Ayeb; Hervé Rochat
Bot IT2: a new scorpion toxin to study receptor site on insect sodium channels.
FEBS letters 1997;405(1):77-80.
1997: Lamia Borchani; Maria Stankiewicz; Charles Kopeyan; Pascal Mansuelle; Riadh Kharrat; Sandrine Cestèle; Habib Karoui; Hervé Rochat; Marcel Pelhate; Mohamed El Ayeb
Purification, structure and activity of three insect toxins from Buthus occitanus tunetanus venom.
Toxicon : official journal of the International Society on Toxinology 1997;35(3):365-82.
1997: Naziha Marrakchi; Rym Barbouche; S Guermazi; Cassian Bon; Mohamed El Ayeb
Procoagulant and platelet-aggregating properties of cerastocytin from Cerastes cerastes venom.
Toxicon : official journal of the International Society on Toxinology 1997;35(2):261-72.
1997: Ilhem Zenouaki; Riadh Kharrat; Jean-Marc Sabatier; Christiane Devaux; Habib Karoui; Jurphaas van Rietschoten; Mohamed El Ayeb; Hervé Rochat
In vivo protection against Androctonus australis hector scorpion toxin and venom by immunization with a synthetic analog of toxin II.
Vaccine 1997;15(2):187-94.
1997: Mohamed El Ayeb; Habib Karoui
[Venoms and toxins laboratory].
Archives de l'Institut Pasteur de Tunis 1997;74(1-2):97-106.
1997: Naziha Marrakchi; S Guermazi; Mohamed El Ayeb
[The anti-platelet aggregation drugs: new approaches based on snake venom polypeptides].
Archives de l'Institut Pasteur de Tunis 1997;74(1-2):9-15.
1997: Naziha Marrakchi; Rym Barbouche; Cassian Bon; Mohamed El Ayeb
Cerastatin, a new potent inhibitor of platelet aggregation from the venom of the Tunisian viper, Cerastes cerastes.
Toxicon : official journal of the International Society on Toxinology 1997;35(1):125-35.
1996: Riadh Kharrat; Kamel Mabrouk; Marcel Crest; Hervé Darbon; Razika Oughideni; Marie-France Martin-Eauclaire; Guy Jacquet; Mohamed El Ayeb; Jurphaas van Rietschoten; Hervé Rochat; Jean-Marc Sabatier
Chemical synthesis and characterization of maurotoxin, a short scorpion toxin with four disulfide bridges that acts on K+ channels.
European journal of biochemistry / FEBS 1996;242(3):491-8.
1996: Lamia Borchani; Pascal Mansuelle; Maria Stankiewicz; F Grolleau; Sandrine Cestèle; Habib Karoui; Bruno Lapied; Hervé Rochat; Marcel Pelhate; Mohamed El Ayeb
A new scorpion venom toxin paralytic to insects that affects Na+ channel activation. Purification, structure, antigenicity and mode of action.
European journal of biochemistry / FEBS 1996;241(2):525-32.
1996: Rym Barbouche; Naziha Marrakchi; Pascal Mansuelle; Mohamed Naceur Krifi; Emmanuel Fenouillet; Hervé Rochat; Mohamed El Ayeb
Novel anti-platelet aggregation polypeptides from Vipera lebetina venom: isolation and characterization.
FEBS letters 1996;392(1):6-10.
1996: B Bouhaouala-Zahar; Frédéric Ducancel; I Zenouaki; R Ben Khalifa; Lamia Borchani; Marcel Pelhate; Jean-Claude Boulain; Mohamed El Ayeb; A Ménez; Habib Karoui
A recombinant insect-specific alpha-toxin of Buthus occitanus tunetanus scorpion confers protection against homologous mammal toxins.
European journal of biochemistry / FEBS 1996;238(3):653-60.
1996: Mohamed Naceur Krifi; Mohamed El Ayeb; Koussay Dellagi
New procedures and parameters for better evaluation of Androctonus australis garzonii (Aag) and Buthus occitanus tunetanus (Bot) scorpion envenomations and specific serotherapy treatment.
Toxicon : official journal of the International Society on Toxinology 1996;34(2):257-66.
1995: Naziha Marrakchi; Russolina B Zingali; Habib Karoui; Cassian Bon; Mohamed El Ayeb
Cerastocytin, a new thrombin-like platelet activator from the venom of the Tunisian viper Cerastes cerastes.
Biochimica et biophysica acta 1995;1244(1):147-56.
1994: Naziha Marrakchi; Rym Barbouche; L Zinghali; Mohamed Naceur Krifi; Cassian Bon; Mohamed El Ayeb
[Biochemical and pharmacologic properties of platelet aggregants and platelet antiaggregants of viper venoms in Tunisia].
Archives de l'Institut Pasteur de Tunis 1994;71(3-4):487-91.
1994: A Gasmi; A Chabchoub; S Guermazi; Habib Karoui; Mohamed El Ayeb; Koussay Dellagi
[Purification, characterization and evaluation of the thrombolytic activity of a fibrinogenase isolated from Vipera lebetina venom].
Archives de l'Institut Pasteur de Tunis 1994;71(3-4):483-6.
1994: Mohamed Naceur Krifi; Mohamed El Ayeb; L el Afrit; Koussay Dellagi
[Toxicokinetics and experimental serotherapy in scorpion envenomation].
Archives de l'Institut Pasteur de Tunis 1994;71(3-4):479-82.
1994: Habib Karoui; B Bouhaouala; Mohamed El Ayeb
[Gene cloning and sequencing of Buthus occitanus tunetanus scorpion toxins].
Archives de l'Institut Pasteur de Tunis 1994;71(3-4):477-8.
1994: Riadh Kharrat; I Zenouaki; Jean-Marc Sabatier; Z Belasfar; K Miled; Habib Karoui; Jurphaas van Rietschoten; Koussay Dellagi; Hervé Rochat; Mohamed El Ayeb
[Preparation of antivenins to scorpion venoms and a protection trials in animal models].
Archives de l'Institut Pasteur de Tunis 1994;71(3-4):473-6.
1994: Mohamed El Ayeb; Lamia Borchani; Riadh Kharrat; Habib Karoui; Marcel Pelhate; Hervé Rochat
[Scorpion toxins: a study model of the structure-function relation of proteins].
Archives de l'Institut Pasteur de Tunis 1994;71(3-4):469-72.
1994: A Gasmi; Hechmi Louzir; Habib Karoui; Mohamed El Ayeb; Koussay Dellagi
Purification from Vipera lebetina (desert adder) venom of a protein that depletes human complement.
Natural toxins 1994;2(1):44-8.
1993: Mohamed Naceur Krifi; Mohamed El Ayeb; Z Ben Lasfar; M Goyffon; Koussay Dellagi
Improvement and standardization of antivenoms sera: snake venoms preparation.
Archives de l'Institut Pasteur de Tunis 1993;70(1-2):5-12.
1992: Mohamed Naceur Krifi; Mohamed El Ayeb; Z Ben Lasfar; K Miled; Koussay Dellagi
Improvement and standardization of antivenoms sera.
Archives de l'Institut Pasteur de Tunis 1992;69(3-4):253-61.
1991: A Gasmi; M Karoui; Z Benlasfar; Habib Karoui; Mohamed El Ayeb; Koussay Dellagi
Purification and characterization of a fibrinogenase from Vipera lebetina (desert adder) venom.
Toxicon : official journal of the International Society on Toxinology 1991;29(7):827-36.
1990: M L Defendini; Elmostafa Bahraoui; CATHERINE LABBE-JULLIE; A Regnier-Vigouroux; Mohamed El Ayeb; Jurphaas van Rietschoten; Hervé Rochat; Claude Granier
Identification of antigenic residues on apamin recognized by polyclonal antibodies.
Molecular immunology 1990;27(1):37-44.
1989: Elmostafa Bahraoui; Mohamed El Ayeb; Claude Granier; L Beress; H Rochat
Specificity of antibodies to sea anemone toxin III and immunogenicity of the pharmacological site of anemone and scorpion toxins.
European journal of biochemistry / FEBS 1989;180(1):55-60.
1988: A Régnier-Vigouroux; Mohamed El Ayeb; M L Defendini; Claude Granier; M Pierres
Processing by accessory cells for presentation to murine T cells of apamin, a disulfide-bonded 18 amino acid peptide.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(4):1069-75.
1988: A Gasmi; Habib Karoui; L el Afrit; Mohamed El Ayeb
[Identification of toxic components from the venom of Cerastes cerastes and Vipera lebetina vipers; purification of phospholipases].
Archives de l'Institut Pasteur de Tunis 1988;65(1-2):43-52.
1988: M L Defendini; Mohamed El Ayeb; A Regnier-Vigouroux; Claude Granier; M Pierres
H-2A-linked control of T-cell and antibody responses to apamin.
Immunogenetics 1988;28(2):139-41.
1987: M F Martin; L G Garcia y Perez; Mohamed El Ayeb; Charles Kopeyan; Guy Bechis; E Jover; Hervé Rochat
Purification and chemical and biological characterizations of seven toxins from the Mexican scorpion, Centruroides suffusus suffusus.
The Journal of biological chemistry 1987;262(10):4452-9.
1986: Mohamed El Ayeb; Elmostafa Bahraoui; Claude Granier; L Beress; H Rochat
Immunochemistry of sea anemone toxins: structure-antigenicity relationships and toxin-receptor interactions probed by antibodies specific for one antigenic region.
Biochemistry 1986;25(22):6755-61.
1986: Mohamed El Ayeb; Elmostafa Bahraoui; Claude Granier; H Rochat
Use of antibodies specific to defined regions of scorpion alpha-toxin to study its interaction with its receptor site on the sodium channel.
Biochemistry 1986;25(21):6671-8.
1986: Elmostafa Bahraoui; Claude Granier; Jurphaas van Rietschoten; H Rochat; Mohamed El Ayeb
Specificity and neutralizing capacity of antibodies elicited by a synthetic peptide of scorpion toxin.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(9):3371-7.
1986: Mohamed El Ayeb; Hervé Darbon; Elmostafa Bahraoui; O Vargas; H Rochat
Differential effects of defined chemical modifications on antigenic and pharmacological activities of scorpion alpha and beta toxins.
European journal of biochemistry / FEBS 1986;155(2):289-94.
1984: Mohamed El Ayeb; Elmostafa Bahraoui; Claude Granier; P Delori; Jurphaas van Rietschoten; Hervé Rochat
Immunochemistry of scorpion alpha-toxins: purification and characterization of two functionally independent IgG populations raised against toxin II of Androctonus australis Hector.
Molecular immunology 1984;21(3):223-32.
1983: Mohamed El Ayeb; M F Martin; P Delori; Guy Bechis; Hervé Rochat
Immunochemistry of scorpion alpha-neurotoxins. Determination of the antigenic site number and isolation of a highly enriched antibody specific to a single antigenic site of toxin II of Androctonus australis Hector.
Molecular immunology 1983;20(7):697-708.
1983: Mohamed El Ayeb; P Delori; Hervé Rochat
Immunochemistry of scorpion alpha-toxins: antigenic homologies checked with radioimmunoassays (RIA).
Toxicon : official journal of the International Society on Toxinology 1983;21(5):709-16.