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Wafik El-Deiry

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Mouse

Genes & Molecular Sequences

Genes, p53

Disorders

Physiology

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Publications

TOP 3
Joshua E Allen; David T Dicker; Nathan G Dolloff; Gabriel Krigsfeld; Patrick A Mayes; Evangelos Messaris; Akshal S Patel; Luv Patel; Kimberly A Scata; Wenge Wang; Gen Sheng Wu; Jun-Ying Zhou; Wafik S El-Deiry
Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects.
Joshua E Allen; Wafik S El-Deiry
Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on β-catenin.
Joshua E Allen; Shantu Amin; David T Dicker; Jean-Nicolas Gallant; Rosalyn B Irby; Arun K Sharma; Wafik S El-Deiry
The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer.

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All Publications

2013: Joshua E Allen; David T Dicker; Nathan G Dolloff; Gabriel Krigsfeld; Patrick A Mayes; Evangelos Messaris; Akshal S Patel; Luv Patel; Kimberly A Scata; Wenge Wang; Gen Sheng Wu; Jun-Ying Zhou; Wafik S El-Deiry
Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects.
Science translational medicine 2013;5(171):171ra17.
2013: Joshua E Allen; Wafik S El-Deiry
Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on β-catenin.
Oncotarget 2013;4(2):184-91.
2013: Joshua E Allen; Shantu Amin; David T Dicker; Jean-Nicolas Gallant; Rosalyn B Irby; Arun K Sharma; Wafik S El-Deiry
The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer.
PloS one 2013;8(3):e59380.
2013: Wafik S El-Deiry
Impact of genetic targets on cancer therapy. Forward.
Advances in experimental medicine and biology 2013;779():v-vi.
2013: Jamal Joudeh; Varun Prabhu; Michael Farbaniec; Jeffrey Adler; Joshua E Allen; Avisnata Das; Wafik S El-Deiry
Novel antineoplastics targeting genetic changes in colorectal cancer.
Advances in experimental medicine and biology 2013;779():1-34.
2013: Noel A Warfel; Wafik S El-Deiry
p21WAF1 and tumourigenesis: 20 years after.
Current opinion in oncology 2013;25(1):52-8.
2012: Varun V Prabhu; Shengliang Zhang; Joshua E Allen; Hairong Cheng; Bo Hong; Wafik S El-Deiry
Therapeutic targeting of the p53 pathway in cancer stem cells.
Expert opinion on therapeutic targets 2012;16(12):1161-74.
2012: Nathan G Dolloff; Joshua E Allen; Nicole Aqui; David T Dicker; Jozef Malysz; Giampaolo Talamo; Dan Vogl; Wafik S El-Deiry
Sangivamycin-like molecule 6 exhibits potent anti-multiple myeloma activity through inhibition of cyclin-dependent kinase-9.
Molecular cancer therapeutics 2012;11(11):2321-30.
2012: R N Crowder; Wafik S El-Deiry
Caspase-8 regulation of TRAIL-mediated cell death.
Experimental oncology 2012;34(3):160-4.
2012: Joshua E Allen; Wafik S El-Deiry
Regulation of the human TRAIL gene.
Cancer biology & therapy 2012;13(12):1143-51.
2012: Joshua E Allen; Glenda Batzer; Elise Chen; David T Dicker; Roger Ferrini; Anke Kretz-Rommel; Bing Lin; Daniela I Oltean; Mark W Renshaw; Wafik S El-Deiry
Targeting TRAIL death receptor 4 with trivalent DR4 Atrimer complexes.
Molecular cancer therapeutics 2012;11(10):2087-95.
2012: Hairong Cheng; David T Dicker; Joshua E Allen; Bo Hong; Robin Humphreys; Yingqiu Y Liu; Guihua Tai; Lanlan Zhou; Wafik S El-Deiry
Mitomycin C potentiates TRAIL-induced apoptosis through p53-independent upregulation of death receptors: evidence for the role of c-Jun N-terminal kinase activation.
Cell cycle (Georgetown, Tex.) 2012;11(17):3312-23.
2012: Varun V Prabhu; Noel A Warfel; Wafik S El-Deiry
CTGF-mediated autophagy-senescence transition in tumor stroma promotes anabolic tumor growth and metastasis.
Cell cycle (Georgetown, Tex.) 2012;11(14):2592-3.
2012: Xiaole Mao; J Philip McCoy; Ahmad Ahsan Nawaz; Yanhui Zhao; Wafik S El-Deiry; Michael Ian Lapsley; Sz-Chin Steven Lin; Tony Jun Huang
An integrated, multiparametric flow cytometry chip using "microfluidic drifting" based three-dimensional hydrodynamic focusing.
Biomicrofluidics 2012;6(2):24113-241139.
2011: Sophie C Cazanave; Wafik S El-Deiry; Christian D Fingas; Niklas Finnberg; Scott H Kaufmann; X Wei Meng; Justin L Mott; Nathan W Werneburg; Steven F Bronk; Gregory J Gores
Death receptor 5 signaling promotes hepatocyte lipoapoptosis.
The Journal of biological chemistry 2011;286(45):39336-48.
2011: Niklas K Finnberg; Lori S Hart; Zachary B Rodgers; David T Dicker; Nathan G Dolloff; Wafik S El-Deiry
High-resolution imaging and antitumor effects of GFP(+) bone marrow-derived cells homing to syngeneic mouse colon tumors.
The American journal of pathology 2011;179(5):2169-76.
2011: Akshal S Patel; Kristi L Peters; Jonas M Sheehan; Joshua E Allen; David T Dicker; Michael J Glantz; Wafik S El-Deiry
Identification and enumeration of circulating tumor cells in the cerebrospinal fluid of breast cancer patients with central nervous system metastases.
Oncotarget 2011;2(10):752-60.
2011: Christina Leah Kline; Jason Liao; Angelique Scicchitano; Hassan S Sheikh; Jeffrey Sivik; Cheryl Beachler; Niklas K Finnberg; Rebecca Gingrich; Wafik S El-Deiry
Preliminary observations indicate variable patterns of plasma 5-fluorouracil (5-FU) levels during dose optimization of infusional 5-FU in colorectal cancer patients.
Cancer biology & therapy 2011;12(7):557-68.
2011: LanLan Zhou; David T Dicker; Robin C Humphreys; Wenge Wang; Wafik S El-Deiry
Prediction of proapoptotic anticancer therapeutic response in vivo based on cell death visualization and TRAIL death ligand-receptor interaction.
Cancer biology & therapy 2011;12(4):335-48.
2011: David T Dicker; Keith T Flaherty; Nadia Kahn; Jeremy Lerner; Wafik S El-Deiry
Hyperspectral imaging: a non-invasive method of imaging melanoma lesions in a patient with stage IV melanoma, being treated with a RAF inhibitor.
Cancer biology & therapy 2011;12(4):326-34.
2011: Nathan G Dolloff; Robin C Humphreys; Lin Z Li; Xiahong Ma; David T Dicker; Wafik S El-Deiry
Spectral imaging-based methods for quantifying autophagy and apoptosis.
Cancer biology & therapy 2011;12(4):349-56.
2011: Joshua E Allen; Wafik S El-Deiry
Oxaliplatin uses JNK to restore TRAIL sensitivity in cancer cells through Bcl-xL inactivation.
Gastroenterology 2011;141(2):430-4.
2011: Patrick A Mayes; Rosalie C Sears; Joshua E Allen; J Martin Brown; Colin J Daniel; David T Dicker; Nathan G Dolloff; Jay F Dorsey; Emma E Furth; Lori S Hart; David I H Jee; Peter S Klein; Kageaki Kuribayashi; J Judy Liu; Yingqiu Y Liu; Wafik S El-Deiry
Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1.
Cancer research 2011;71(15):5265-75.
2011: Bishoy Faltas; Harold A Harvey; Yixing Jiang; Jamal Joudeh; Arunasalam Navaraj; Kristi Peters; Amer Zeidan; Joshua E Allen; Avisnata Das; David T Dicker; Nathan G Dolloff; Wafik S El-Deiry
Identifying circulating tumor stem cells that matter: the key to prognostication and therapeutic targeting.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(21):2946-7; author reply 2947-8.
2011: Sharyn I Katz; Lanlan Zhou; Thomas A Ferrara; Wenge Wang; Patrick A Mayes; Charles D Smith; Wafik S El-Deiry
FLT-PET may not be a reliable indicator of therapeutic response in p53-null malignancy.
International journal of oncology 2011;39(1):91-100.
2011: Nathan G Dolloff; Lori S Hart; Robin Humphreys; Patrick A Mayes; David T Dicker; Wafik S El-Deiry
Off-target lapatinib activity sensitizes colon cancer cells through TRAIL death receptor up-regulation.
Science translational medicine 2011;3(86):86ra50.
2010: Junaid Abdulghani; Wafik S El-Deiry
TRAIL receptor signaling and therapeutics.
Expert opinion on therapeutic targets 2010;14(10):1091-108.
2010: Fang Chen; Wenge Wang; Wafik S El-Deiry
Current strategies to target p53 in cancer.
Biochemical pharmacology 2010;80(5):724-30.
2010: P E McGovern; Melpo Christofidou-Solomidou; W Wang; F Dukes; T Davidson; Wafik S El-Deiry
Anticancer activity of botanical compounds in ancient fermented beverages (review).
International journal of oncology 2010;37(1):5-14.
2010: Wafik S El-Deiry
Funding the marathon: investigators need more than basic experiments and clinical trials to advance the war on cancer.
Cancer biology & therapy 2010;9(10):751-3.
2009: Elizabeth M Matthew; Lori S Hart; Aristotelis Astrinidis; Arunasalam Navaraj; Nathan G Dolloff; David T Dicker; Elizabeth Petri Henske; Wafik S El-Deiry
The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.
Cell cycle (Georgetown, Tex.) 2009;8(24):4168-75.
2009: Arunasalam Navaraj; Niklas Finnberg; David T Dicker; Wensheng Yang; Elizabeth M Matthew; Wafik S El-Deiry
Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras.
Cancer biology & therapy 2009;8(24):2417-44.
2009: Sharyn I Katz; Lanlan Zhou; Grace Chao; Charles D Smith; Thomas Ferrara; Wenge Wang; David T Dicker; Wafik S El-Deiry
Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma.
Cancer biology & therapy 2009;8(24):2406-16.
2009: Jay F Dorsey; Akiva Mintz; Xiaobing Tian; Melissa L Dowling; John P Plastaras; David T Dicker; Gary D Kao; Wafik S El-Deiry
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative in vivo effects against glioblastoma multiforme cells.
Molecular cancer therapeutics 2009;8(12):3285-95.
2009: Takao Ide; Lauren Brown-Endres; Kiki Chu; Pat P Ongusaha; Takao Ohtsuka; Wafik S El-Deiry; Stuart A Aaronson; Sam W Lee
GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress.
Molecular cell 2009;36(3):379-92.
2009: Catherine Huang; Xiang M Zhang; Raluca T Tavaluc; Lori S Hart; David T Dicker; Wenge Wang; Wafik S El-Deiry
The combination of 5-fluorouracil plus p53 pathway restoration is associated with depletion of p53-deficient or mutant p53-expressing putative colon cancer stem cells.
Cancer biology & therapy 2009;8(22):2186-93.
2009: Joshua E Allen; Lori S Hart; David T Dicker; Wenge Wang; Wafik S El-Deiry
Visualization and enrichment of live putative cancer stem cell populations following p53 inactivation or Bax deletion using non-toxic fluorescent dyes.
Cancer biology & therapy 2009;8(22):2194-205.
2009: Lanlan Zhou; Wafik S El-Deiry
Multispectral fluorescence imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(10):1563-6.
2009: Chris O Wambi; Jenine K Sanzari; Carly M Sayers; Manunya Nuth; Zhaozong Zhou; James Davis; Niklas Finnberg; Joan S Lewis-Wambi; Jeffrey H Ware; Wafik S El-Deiry; Ann R Kennedy
Protective effects of dietary antioxidants on proton total-body irradiation-mediated hematopoietic cell and animal survival.
Radiation research 2009;172(2):175-86.
2009: L Galluzzi; S A Aaronson; J Abrams; E S Alnemri; D W Andrews; E H Baehrecke; N G Bazan; M V Blagosklonny; K Blomgren; C Borner; Dale E Bredesen; C Brenner; M Castedo; J A Cidlowski; Aaron Ciechanover; G M Cohen; V De Laurenzi; R De Maria; Mohanish Deshmukh; Brian David Dynlacht; Wafik S El-Deiry; R A Flavell; S Fulda; C Garrido; P Golstein; M-L Gougeon; D R Green; Hinrich Gronemeyer; Gyorgy Hajn\u2264czky; J Marie Hardwick; M O Hengartner; H Ichijo; M Jäättelä; O Kepp; A Kimchi; Daniel J Klionsky; R A Knight; Sally Kornbluth; S Kumar; Beth Levine; S A Lipton; E Lugli; F Madeo; W Malomi; J-C W Marine; S J Martin; J P Medema; P Mehlen; G Melino; Ute M Moll; E Morselli; S Nagata; D W Nicholson; P Nicotera; G Nuñez; M Oren; J Penninger; S Pervaiz; M E Peter; M Piacentini; J H M Prehn; H Puthalakath; G A Rabinovich; R Rizzuto; C M P Rodrigues; David C Rubinsztein; T Rudel; LUCA SCORRANO; H-U Simon; H Steller; J Tschopp; Y Tsujimoto; P Vandenabeele; I Vitale; K H Vousden; R J Youle; J Yuan; B Zhivotovsky; G Kroemer
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.
Cell death and differentiation 2009;16(8):1093-107.
2009: Lori S Hart; Wafik S El-Deiry
Cell death: a new Par-4 the TRAIL.
Cell 2009;138(2):220-2.
2009: Chao Lu; Wafik S El-Deiry
Targeting p53 for enhanced radio- and chemo-sensitivity.
Apoptosis : an international journal on programmed cell death 2009;14(4):597-606.
2009: G Kroemer; L Galluzzi; P Vandenabeele; John M Abrams; E S Alnemri; E H Baehrecke; M V Blagosklonny; Wafik S El-Deiry; P Golstein; D R Green; Michael O. Hengartner; R A Knight; S Kumar; S A Lipton; W Malorni; G Nuñez; M E Peter; J Tschopp; J Yuan; M Piacentini; B Zhivotovsky; G Melino
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009.
Cell death and differentiation 2009;16(1):3-11.
2008: Chao Lu; Wenge Wang; Wafik S El-Deiry
Non-genotoxic anti-neoplastic effects of ellipticine derivative NSC176327 in p53-deficient human colon carcinoma cells involve stimulation of p73.
Cancer biology & therapy 2008;7(12):2039-46.
2008: John P Plastaras; Jay F Dorsey; Kristina Carroll; Seok-Hyun Kim; Morris J Birnbaum; Wafik S El-Deiry
Role of PI3K/Akt signaling in TRAIL- and radiation-induced gastrointestinal apoptosis.
Cancer biology & therapy 2008;7(12):2047-53.
2008: Kageaki Kuribayashi; Gabriel Krigsfeld; Wenge Wang; Jing Xu; Patrick A Mayes; David T Dicker; Gen Sheng Wu; Wafik S El-Deiry
TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death.
Cancer biology & therapy 2008;7(12):2034-8.
2008: Niklas Finnberg; Chris Wambi; Jeffrey H Ware; Ann R Kennedy; Wafik S El-Deiry
Gamma-radiation (GR) triggers a unique gene expression profile associated with cell death compared to proton radiation (PR) in mice in vivo.
Cancer biology & therapy 2008;7(12):2023-33.
2008: Emily A Bassett; Wenge Wang; Farzan Rastinejad; Wafik S El-Deiry
Structural and functional basis for therapeutic modulation of p53 signaling.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(20):6376-86.
2008: Patrick Mayes; David Dicker; Yingqiu Liu; Wafik S El-Deiry
Noninvasive vascular imaging in fluorescent tumors using multispectral unmixing.
BioTechniques 2008;45(4):459-60, 461-4.
2008: Lori S Hart; Wafik S El-Deiry
Invincible, but not invisible: imaging approaches toward in vivo detection of cancer stem cells.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(17):2901-10.
2008: Niklas Finnberg; Wafik S El-Deiry
TRAIL death receptors as tumor suppressors and drug targets.
Cell cycle (Georgetown, Tex.) 2008;7(11):1525-8.
2008: Kazuhiro Noma; Keiran S M Smalley; Mercedes Lioni; Yoshio Naomoto; Noriaki Tanaka; Wafik S El-Deiry; Alastair J King; Hiroshi Nakagawa; Meenhard Herlyn
The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis.
Gastroenterology 2008;134(7):1981-93.
2008: Wentao Liao; Qi Xiao; Vladimir Tchikov; Ken-ichi Fujita; Wensheng Yang; Stephen Wincovitch; Susan Garfield; Dietrich Conze; Wafik S El-Deiry; Stefan Schütze; Srinivasa M Srinivasula
CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation.
Current biology : CB 2008;18(9):641-9.
2008: Mijin Kim; Jessica Liao; Melissa Dowling; K Ranh Voong; Sharon E Parker; Shulin Wang; Wafik S El-Deiry; Gary D Kao
TRAIL inactivates the mitotic checkpoint and potentiates death induced by microtubule-targeting agents in human cancer cells.
Cancer research 2008;68(9):3440-9.
2008: Seok-Hyun Kim; M Stacey Ricci; Wafik S El-Deiry
Mcl-1: a gateway to TRAIL sensitization.
Cancer research 2008;68(7):2062-4.
2008: Wensheng Yang; David T Dicker; Jiandong Chen; Wafik S El-Deiry
CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2.
Cell cycle (Georgetown, Tex.) 2008;7(5):670-82.
2008: Wensheng Yang; Nathan G Dolloff; Wafik S El-Deiry
ERK and MDM2 prey on FOXO3a.
Nature cell biology 2008;10(2):125-6.
2008: Luciana M Laguinge; Raed N Samara; Wenge Wang; Wafik S El-Deiry; Georgia A Corner; Leonard H Augenlicht; Lopa Mishra; J Milburn Jessup
DR5 receptor mediates anoikis in human colorectal carcinoma cell lines.
Cancer research 2008;68(3):909-17.
2008: Kageaki Kuribayashi; Niklas Finnberg; Wafik S El-Deiry
Studying p53-dependent cell death in vitro and in vivo.
Methods in enzymology 2008;446():159-73.
2008: Kageaki Kuribayashi; Wafik S El-Deiry
Regulation of programmed cell death by the p53 pathway.
Advances in experimental medicine and biology 2008;615():201-21.
2008: Niklas Finnberg; Andres J P Klein-Szanto; Wafik S El-Deiry
TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis.
The Journal of clinical investigation 2008;118(1):111-23.
2008: Wenge Wang; Wafik S El-Deiry
Restoration of p53 to limit tumor growth.
Current opinion in oncology 2008;20(1):90-6.
2007: Paul G Corn; Wafik S El-Deiry
Microarray analysis of p53-dependent gene expression in response to hypoxia and DNA damage.
Cancer biology & therapy 2007;6(12):1858-66.
2007: Wafik S El-Deiry
Targeting mutant p53 shows promise for sunscreens and skin cancer.
The Journal of clinical investigation 2007;117(12):3658-60.
2007: Wensheng Yang; Wafik S El-Deiry
CARPs are E3 ligases that target apical caspases and p53.
Cancer biology & therapy 2007;6(11):1676-83.
2007: Takaomi Okawa; Carmen Z Michaylira; Jiri Kalabis; Douglas B Stairs; Hiroshi Nakagawa; Claudia D Andl; Cameron N Johnstone; Andres J P Klein-Szanto; Wafik S El-Deiry; Edna Cukierman; Meenhard Herlyn; Anil K Rustgi
The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation.
Genes & development 2007;21(21):2788-803.
2007: Elizabeth M Matthew; Tim J Yen; David T Dicker; Jay F Dorsey; Wensheng Yang; Arunasalam Navaraj; Wafik S El-Deiry
Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells.
Cell cycle (Georgetown, Tex.) 2007;6(20):2571-8.
2007: Raluca T Tavaluc; Lori S Hart; David T Dicker; Wafik S El-Deiry
Effects of low confluency, serum starvation and hypoxia on the side population of cancer cell lines.
Cell cycle (Georgetown, Tex.) 2007;6(20):2554-62.
2007: David T Dicker; Jeremy Lerner; Wafik S El-Deiry
Hyperspectral image analysis of live cells in various cell cycle stages.
Cell cycle (Georgetown, Tex.) 2007;6(20):2563-70.
2007: Tapan N Maniar; Inbal Braunstein; Stephen Keefe; Sofia Hussen; Tara Abrams; Angela De Michele; Wafik S El-Deiry
Childhood ALL and second neoplasms.
Cancer biology & therapy 2007;6(10):1525-31.
2007: Shulin Wang; Akiva Mintz; Kenjiro Mochizuki; Jay F Dorsey; Joseph M Ackermann; Abass Alavi; Wafik S El-Deiry
Multimodality optical imaging and 18F-FDG uptake in wild-type p53-containing and p53-null human colon tumor xenografts.
Cancer biology & therapy 2007;6(10):1649-53.
2007: John P Plastaras; Seok-Hyun Kim; Yingqiu Y Liu; David T Dicker; Jay F Dorsey; James McDonough; george cerniglia; Ramji R Rajendran; Anjali Gupta; Anil K Rustgi; J Alan Diehl; Charles D Smith; Keith T Flaherty; Wafik S El-Deiry
Cell cycle dependent and schedule-dependent antitumor effects of sorafenib combined with radiation.
Cancer research 2007;67(19):9443-54.
2007: Robyn T Sussman; M Stacey Ricci; Lori S Hart; Shi Yong Sun; Wafik S El-Deiry
Chemotherapy-resistant side-population of colon cancer cells has a higher sensitivity to TRAIL than the non-SP, a higher expression of c-Myc and TRAIL-receptor DR4.
Cancer biology & therapy 2007;6(9):1490-5.
2007: M Stacey Ricci; Seok-Hyun Kim; Kazuhiro Ogi; John P Plastaras; Jianhua Ling; Wenge Wang; Zhaoyu Jin; Yingqiu Y Liu; David T Dicker; Paul J Chiao; Keith T Flaherty; Charles D Smith; Wafik S El-Deiry
Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death.
Cancer cell 2007;12(1):66-80.
2007: Kenji Oyama; Takaomi Okawa; Hiroshi Nakagawa; Munenori Takaoka; Claudia D Andl; Seok-Hyun Kim; Andres Klein-Szanto; J Alan Diehl; Meenhard Herlyn; Wafik S El-Deiry; Anil K Rustgi
AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture.
Oncogene 2007;26(16):2353-64.
2007: Munenori Takaoka; Seok-Hyun Kim; Takaomi Okawa; Carmen Z Michaylira; Douglas B Stairs; Cameron N Johnstone; Claudia D Andl; Ben Rhoades; James J Lee; Andres J P Klein-Szanto; Wafik S El-Deiry; Hiroshi Nakagawa
IGFBP-3 regulates esophageal tumor growth through IGF-dependent and independent mechanisms.
Cancer biology & therapy 2007;6(4):534-40.
2007: Paul C Tumeh; Jeremy Lerner; David T Dicker; Wafik S El-Deiry
Differentiation of vascular and non-vascular skin spectral signatures using in vivo hyperspectral radiometric imaging: implications for monitoring angiogenesis.
Cancer biology & therapy 2007;6(3):447-53.
2007: Wensheng Yang; Laura M Rozan; E Robert McDonald; Arunasalam Navaraj; Jue Judy Liu; Elizabeth M Matthew; Wenge Wang; David T Dicker; Wafik S El-Deiry
CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation.
The Journal of biological chemistry 2007;282(5):3273-81.
2007: Mercedes Lioni; Patricia Brafford; Claudia D Andl; Anil K Rustgi; Wafik S El-Deiry; Meenhard Herlyn; Keiran Smalley
Dysregulation of claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells.
The American journal of pathology 2007;170(2):709-21.
2007: Kimberly A Scata; Wafik S El-Deiry
p53, BRCA1 and breast Cancer chemoresistance.
Advances in experimental medicine and biology 2007;608():70-86.
2007: Gary J Kelloff; Daniel C Sullivan; Houston Baker; Lawrence P Clarke; Robert Nordstrom; James L Tatum; Gary S Dorfman; Paula Jacobs; Christine D Berg; Martin G Pomper; Michael J Birrer; Margaret Tempero; Howard R Higley; Brenda Gumbs Petty; Caroline C Sigman; Carlo Maley; Prateek Sharma; Adam Wax; Gregory G Ginsberg; Andrew J Dannenberg; Ernest T Hawk; Edward M Messing; H Barton Grossman; Mukesh Harisinghani; Irving J Bigio; Donna Griebel; Donald E Henson; Carol J Fabian; Katherine Ferrara; Sergio Fantini; Mitchell D Schnall; Jo Anne Zujewski; Wendy Hayes; Eric A Klein; Angelo M DeMarzo; Iclal Ocak; Jeffrey A Ketterling; Clare Tempany; Faina Shtern; Howard L Parnes; Jorge Gomez; sudhir srivastava; Eva Szabo; Stephen Lam; Eric J Seibel; Pierre Massion; Geoffrey McLennan; Kevin Cleary; Robert Suh; Randall W Burt; Ruth M Pfeiffer; John M Hoffman; Hemant K Roy; Thomas D Wang; Paul J Limburg; Wafik S El-Deiry; Vali Papadimitrakopoulou; Walter N Hittelman; Calum MacAulay; Robert W Veltri; Diane Solomon; Jose Jeronimo; Rebecca Richards-Kortum; Karen A Johnson; Jaye L Viner; Steven P Stratton; Milind Rajadhyaksha; Atam Dhawan
Workshop on imaging science development for cancer prevention and preemption.
Cancer biomarkers : section A of Disease markers 2007;3(1):1-33.
2007: Laura M Rozan; Wafik S El-Deiry
p53 downstream target genes and tumor suppression: a classical view in evolution.
Cell death and differentiation 2007;14(1):3-9.
2006: Seok-Hyun Kim; Hiroshi Nakagawa; Arunasalam Navaraj; Yoshio Naomoto; Andres J P Klein-Szanto; Anil K Rustgi; Wafik S El-Deiry
Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous Ras.
Cancer research 2006;66(21):10415-24.
2006: Zhaoyu Jin; Wafik S El-Deiry
Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis.
Molecular and cellular biology 2006;26(21):8136-48.
2006: Adda Grimberg; Carrie M Coleman; Zonggao Shi; Timothy F Burns; Timothy K MacLachlan; Wenge Wang; Wafik S El-Deiry
Insulin-like growth factor factor binding protein-2 is a novel mediator of p53 inhibition of insulin-like growth factor signaling.
Cancer biology & therapy 2006;5(10):1408-14.
2006: Kimberly A Scata; Wafik S El-Deiry
Taming NEMO to slay cancer cells.
Cancer biology & therapy 2006;5(9):1096-7.
2006: Laura M Rozan; Wafik S El-Deiry
Identification and characterization of proteins interacting with Traf4, an enigmatic p53 target.
Cancer biology & therapy 2006;5(9):1228-35.
2006: David T Dicker; Jeremy Lerner; Patricia Van Belle; Stephen F Barth; DuPont Guerry; Meenhard Herlyn; David E Elder; Wafik S El-Deiry
Differentiation of normal skin and melanoma using high resolution hyperspectral imaging.
Cancer biology & therapy 2006;5(8):1033-8.
2006: Jun Tang; Like Qu; Jianke Zhang; Wenge Wang; Jennifer S Michaelson; Yan Y Degenhardt; Wafik S El-Deiry; Xiaolu Yang
Critical role for Daxx in regulating Mdm2.
Nature cell biology 2006;8(8):855-62.
2006: Wenge Wang; Seok-Hyun Kim; Wafik S El-Deiry
Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):11003-8.
2006: Niklas Finnberg; Wafik S El-Deiry
Selective TRAIL-induced apoptosis in dysplastic neoplasia of the colon may lead to new neoadjuvant or adjuvant therapies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 1):4132-6.
2006: Shulin Wang; Wafik S El-Deiry
p73 or p53 directly regulates human p53 transcription to maintain cell cycle checkpoints.
Cancer research 2006;66(14):6982-9.
2006: Wafik S El-Deiry; Caroline C Sigman; Gary J Kelloff
Imaging and oncologic drug development.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(20):3261-73.
2006: Patrick A Mayes; Wafik S El-Deiry
The complementary roles of the extrinsic and intrinsic apoptotic pathways in promoting the death of cancer cells.
Cancer journal (Sudbury, Mass.) 2006;12(4):247-9.
2006: Kageaki Kuribayashi; Patrick A Mayes; Wafik S El-Deiry
What are caspases 3 and 7 doing upstream of the mitochondria?
Cancer biology & therapy 2006;5(7):763-5.
2006: Wafik S El-Deiry
Lobbying Congress to make cancer funding a priority: what scientists can do.
Cancer biology & therapy 2006;5(5):467-9.
2006: Munenori Takaoka; Caitlin E Smith; Michael K Mashiba; Takaomi Okawa; Claudia D Andl; Wafik S El-Deiry; Hiroshi Nakagawa
EGF-mediated regulation of IGFBP-3 determines esophageal epithelial cellular response to IGF-I.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(2):G404-16.
2005: Arunasalam Navaraj; Toshio Mori; Wafik S El-Deiry
Cooperation between BRCA1 and p53 in repair of cyclobutane pyrimidine dimers.
Cancer biology & therapy 2005;4(12):1409-14.
2005: Jian Wang; Vikram Devgan; Marcella Corrado; Nita S Prabhu; Wafik S El-Deiry; Carlo Riccardi; Pier Paolo Pandolfi; Caterina Missero; G Paolo Dotto
Glucocorticoid-induced tumor necrosis factor receptor is a p21Cip1/WAF1 transcriptional target conferring resistance of keratinocytes to UV light-induced apoptosis.
The Journal of biological chemistry 2005;280(45):37725-31.
2005: Paul G Corn; M Stacey Ricci; Kimberly A Scata; Andrew M Arsham; M Celeste Simon; David T Dicker; Wafik S El-Deiry
Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis.
Cancer biology & therapy 2005;4(11):1285-94.
2005: Guido Kroemer; Wafik S El-Deiry; P Golstein; M E Peter; D Vaux; P Vandenabeele; B Zhivotovsky; M V Blagosklonny; W Malorni; R A Knight; Mauro Piacentini; S Nagata; G Melino
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death.
Cell death and differentiation 2005;12 Suppl 2():1463-7.
2005: Patrick A Mayes; Latoya Campbell; M Stacey Ricci; John P Plastaras; David T Dicker; Wafik S El-Deiry
Modulation of TRAIL-induced tumor cell apoptosis in a hypoxic environment.
Cancer biology & therapy 2005;4(10):1068-74.
2005: Niklas Finnberg; Seok-Hyun Kim; Emma E Furth; Jue Judy Liu; Pierre Russo; David A Piccoli; Adda Grimberg; Wafik S El-Deiry
Non-invasive fluorescence imaging of cell death in fresh human colon epithelia treated with 5-Fluorouracil, CPT-11 and/or TRAIL.
Cancer biology & therapy 2005;4(9):937-42.
2005: David T Dicker; Seok-Hyun Kim; Zhaoyu Jin; Wafik S El-Deiry
Heterogeneity in non-invasive detection of apoptosis among human tumor cell lines using annexin-V tagged with EGFP or Qdot-705.
Cancer biology & therapy 2005;4(9):1014-7.
2005: Wenge Wang; William C Ho; David T Dicker; Colin MacKinnon; Jeffrey D Winkler; Ronen Marmorstein; Wafik S El-Deiry
Acridine derivatives activate p53 and induce tumor cell death through Bax.
Cancer biology & therapy 2005;4(8):893-8.
2005: Jue Judy Liu; Wenge Wang; David T Dicker; Wafik S El-Deiry
Bioluminescent imaging of TRAIL-induced apoptosis through detection of caspase activation following cleavage of DEVD-aminoluciferin.
Cancer biology & therapy 2005;4(8):885-92.
2005: Wafik S El-Deiry
Plagiarism is not acceptable in science or for cancer biology & therapy.
Cancer biology & therapy 2005;4(6):619-20.
2005: Wafik S El-Deiry
Meeting report: The international conference on tumor progression and therapeutic resistance.
Cancer research 2005;65(11):4475-84.
2005: Adda Grimberg; Carrie M Coleman; Timothy F Burns; Bruce P Himelstein; Cameron J Koch; Pinchas Cohen; Wafik S El-Deiry
p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia.
The Journal of clinical endocrinology and metabolism 2005;90(6):3568-74.
2005: Bipin C Dash; Wafik S El-Deiry
Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity.
Molecular and cellular biology 2005;25(8):3364-87.
2005: Niklas Finnberg; Joshua J Gruber; Peiwen Fei; Dorothea Rudolph; Anka Bric; Seok-Hyun Kim; Timothy F Burns; Hope Ajuha; Robert Page; Gen Sheng Wu; Youhai Chen; W Gillies McKenna; Eric J Bernhard; Scott W Lowe; Tak Mak; Wafik S El-Deiry
DR5 knockout mice are compromised in radiation-induced apoptosis.
Molecular and cellular biology 2005;25(5):2000-13.
2005: Zhaoyu Jin; Wafik S El-Deiry
Overview of cell death signaling pathways.
Cancer biology & therapy 2005;4(2):139-63.
2004: Shih-Wen Lin; Michelle Cook; Niklas Finnberg; Eric J Bernhard; Don Baldwin; Wafik S El-Deiry
p53-dependent induction of serine proteases in irradiated mouse colon.
Cancer biology & therapy 2004;3(12):1290-7.
2004: Peiwen Fei; Wenge Wang; Seok-hyun Kim; Shulin Wang; Timothy F Burns; Joanna K Sax; Monica Buzzai; David T Dicker; W Gillies McKenna; Eric J Bernhard; Wafik S El-Deiry
Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth.
Cancer cell 2004;6(6):597-609.
2004: Michael D Tibbetts; Eric N Shiozaki; Lichuan Gu; E Robert McDonald; Wafik S El-Deiry; Yigong Shi
Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2.
Structure (London, England : 1993) 2004;12(12):2257-63.
2004: Munenori Takaoka; Hideki Harada; Claudia D Andl; Kenji Oyama; Yoshio Naomoto; Kelly L Dempsey; Andres J P Klein-Szanto; Wafik S El-Deiry; Adda Grimberg; Hiroshi Nakagawa
Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3.
Cancer research 2004;64(21):7711-23.
2004: M Stacey Ricci; Zhaoyu Jin; Michael Dews; Duonan Yu; Andrei Thomas-Tikhonenko; David T Dicker; Wafik S El-Deiry
Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity.
Molecular and cellular biology 2004;24(19):8541-55.
2004: Seok-Hyun Kim; Kunhong Kim; Jae G Kwagh; David T Dicker; Meenhard Herlyn; Anil K Rustgi; Youhai Chen; Wafik S El-Deiry
Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells.
The Journal of biological chemistry 2004;279(38):40044-52.
2004: Shulin Wang; Wafik S El-Deiry
Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil.
Cancer research 2004;64(18):6666-72.
2004: Peter J Gruber; Zijun Li; Hui Li; Diane Worrad; Bin Huang; Ibrahim Abdullah; Wenge Wang; Wafik S El-Deiry; Victor A Ferrari; Rong Zhou
In vivo imaging of MLC2v-luciferase, a cardiac-specific reporter gene expression in mice.
Academic radiology 2004;11(9):1022-8.
2004: Wenge Wang; Wafik S El-Deiry
Targeting p53 by PTD-mediated transduction.
Trends in biotechnology 2004;22(9):431-4.
2004: Rishita Shah; Wafik S El-Deiry
p53-Dependent activation of a molecular beacon in tumor cells following exposure to doxorubicin chemotherapy.
Cancer biology & therapy 2004;3(9):871-5.
2004: Zhaoyu Jin; E Robert McDonald; David T Dicker; Wafik S El-Deiry
Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis.
The Journal of biological chemistry 2004;279(34):35829-39.
2004: Niklas Finnberg; Wafik S El-Deiry
Activating FOXO3a, NF-kappaB and p53 by targeting IKKs: an effective multi-faceted targeting of the tumor-cell phenotype?
Cancer biology & therapy 2004;3(7):614-6.
2004: Kimberly A Scata; Wafik S El-Deiry
Zebrafish: swimming towards a role for fanconi genes in DNA repair.
Cancer biology & therapy 2004;3(6):501-2.
2004: Andrei Thomas-Tikhonenko; Isabelle Viard-Leveugle; Michael Dews; Philippe Wehrli; Cinzia Sevignani; Duonan Yu; Stacey Ricci; Wafik S El-Deiry; Bruce Aronow; Gürkan Kaya; Jean-Hilaire Saurat; Lars E French
Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo.
Cancer research 2004;64(9):3126-36.
2004: K Kim; H Nakagawa; P Fei; A K Rustgi; Wafik S El-Deiry
Targeting Bcl-xL in esophageal squamous cancer to sensitize to chemotherapy plus TRAIL-induced apoptosis while normal epithelial cells are protected by blockade of caspase 9.
Cell death and differentiation 2004;11(5):583-7.
2004: E Robert McDonald; Wafik S El-Deiry
Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6170-5.
2004: Bipin C Dash; Wafik S El-Deiry
Cell cycle checkpoint control mechanisms that can be disrupted in cancer.
Methods in molecular biology (Clifton, N.J.) 2004;280():99-161.
2004: Shulin Wang; Wafik S El-Deiry
The p53 pathway: targets for the development of novel cancer therapeutics.
Cancer treatment and research 2004;119():175-87.
2004: Wenge Wang; Wafik S El-Deiry
Targeting FOXO kills two birds with one stone.
Chemistry & biology 2004;11(1):16-8.
2004: Shulin Wang; Wafik S El-Deiry
Cytochrome c: a crosslink between the mitochondria and the endoplasmic reticulum in calcium-dependent apoptosis.
Cancer biology & therapy 2004;3(1):44-6.
2003: Shulin Wang; Wafik S El-Deiry
Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15095-100.
2003: Shulin Wang; Wafik S El-Deiry
TRAIL and apoptosis induction by TNF-family death receptors.
Oncogene 2003;22(53):8628-33.
2003: Sanjeev Das; Wafik S El-Deiry; Jeena Joseph
Efficient growth inhibition of HPV 16 E6-expressing cells by an adenovirus-expressing p53 homologue p73beta.
Oncogene 2003;22(52):8394-402.
2003: Bart Rikhof; Paul G Corn; Wafik S El-Deiry
Caspase 10 levels are increased following DNA damage in a p53-dependent manner.
Cancer biology & therapy 2003;2(6):707-12.
2003: Paul G Corn; E Robert McDonald; James G Herman; Wafik S El-Deiry
Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein.
Nature genetics 2003;35(3):229-37.
2003: Wafik S El-Deiry
The role of p53 in chemosensitivity and radiosensitivity.
Oncogene 2003;22(47):7486-95.
2003: Joanna K Sax; Wafik S El-Deiry
Identification and characterization of the cytoplasmic protein TRAF4 as a p53-regulated proapoptotic gene.
The Journal of biological chemistry 2003;278(38):36435-44.
2003: Eugene A Choi; Hanqin Lei; David J Maron; James M Wilson; James Barsoum; Douglas L Fraker; Wafik S El-Deiry; Francis R Spitz
Stat1-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand and the cell-surface death signaling pathway by interferon beta in human cancer cells.
Cancer research 2003;63(17):5299-307.
2003: Peiwen Fei; Wafik S El-Deiry
P53 and radiation responses.
Oncogene 2003;22(37):5774-83.
2003: Timothy F Burns; Peiwen Fei; Kimberly A Scata; David T Dicker; Wafik S El-Deiry
Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells.
Molecular and cellular biology 2003;23(16):5556-71.
2003: Miriam Benezra; Nathalie Chevallier; Debra J Morrison; Timothy K MacLachlan; Wafik S El-Deiry; Jonathan D Licht
BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit.
The Journal of biological chemistry 2003;278(29):26333-41.
2003: Timothy F Burns; Wafik S El-Deiry
Microarray analysis of p53 target gene expression patterns in the spleen and thymus in response to ionizing radiation.
Cancer biology & therapy 2003;2(4):431-43.
2003: Joanna K Sax; Alex Stoddard; Maureen E Murphy; Lewis A Chodosh; Wafik S El-Deiry
Microarray expression profiling of p53-dependent transcriptional changes in an immortalized mouse embryo fibroblast cell line.
Cancer biology & therapy 2003;2(4):416-30.
2003: Wenge Wang; Farzan Rastinejad; Wafik S El-Deiry
Restoring p53-dependent tumor suppression.
Cancer biology & therapy 2003;2(4 Suppl 1):S55-63.
2003: Barbara G Campling; Wafik S El-Deiry
Clinical implication of p53 mutation in lung cancer.
Molecular biotechnology 2003;24(2):141-56.
2003: Sanjeev Das; Wafik S El-Deiry; Jeena Joseph
Regulation of the p53 homolog p73 by adenoviral oncogene E1A.
The Journal of biological chemistry 2003;278(20):18313-20.
2003: Joanna K Sax; Wafik S El-Deiry
p53 downstream targets and chemosensitivity.
Cell death and differentiation 2003;10(4):413-7.
2003: Nesrin Ozören; Wafik S El-Deiry
Cell surface Death Receptor signaling in normal and cancer cells.
Seminars in cancer biology 2003;13(2):135-47.
2003: Claus J Gruss; Kapaettu Satyamoorthy; Carola Berking; John Lininger; Mark Nesbit; Helmut Schaider; Zhao-Jun Liu; Masahiro Oka; Mei-Yu Hsu; Takashi Shirakawa; Gang Li; Thomas Bogenrieder; Peter Carmeliet; Wafik S El-Deiry; Stephen L Eck; Justi S Rao; Andrew H Baker; Jean T Bennet; Timothy M Crombleholme; Omaida Velazquez; Jagajan Karmacharya; David J Margolis; James M Wilson; Michael Detmar; Mihaela Skobe; Paul D Robbins; Clayton Buck; Meenhard Herlyn
Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice.
The Journal of investigative dermatology 2003;120(4):683-92.
2003: Wenge Wang; Wafik S El-Deiry
Bioluminescent molecular imaging of endogenous and exogenous p53-mediated transcription in vitro and in vivo using an HCT116 human colon carcinoma xenograft model.
Cancer biology & therapy 2003;2(2):196-202.
2003: Wenge Wang; Rishu Takimoto; Farzan Rastinejad; Wafik S El-Deiry
Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.
Molecular and cellular biology 2003;23(6):2171-81.
2003: Joanna K Sax; Wafik S El-Deiry
p53-induced gene expression analysis.
Methods in molecular biology (Clifton, N.J.) 2003;234():65-71.
2003: David T Dicker; Wafik S El-Deiry
Flow cytometric analysis of tumor suppressor gene-induced apoptosis.
Methods in molecular biology (Clifton, N.J.) 2003;223():271-82.
2003: Timothy K MacLachlan; Wafik S El-Deiry
Analysis of cyclin-dependent kinase activity.
Methods in molecular biology (Clifton, N.J.) 2003;223():217-20.
2003: David T Dicker; Wafik S El-Deiry
Flow cytometric analysis of cell cycle control by tumor suppressor genes.
Methods in molecular biology (Clifton, N.J.) 2003;223():211-5.
2003: E Robert McDonald; Wafik S El-Deiry
Yeast two-hybrid screening as a means of deciphering tumor suppressor pathways.
Methods in molecular biology (Clifton, N.J.) 2003;223():173-85.
2003: Timothy K MacLachlan; Wafik S El-Deiry
Identification of DNA-binding of tumor suppressor genes by chromatin immunoprecipitation.
Methods in molecular biology (Clifton, N.J.) 2003;223():129-33.
2003: M Stacey Ricci; Wafik S El-Deiry
DNA footprinting.
Methods in molecular biology (Clifton, N.J.) 2003;223():117-27.
2003: Timothy F Burns; Wafik S El-Deiry
Cell death signaling in maligancy.
Cancer treatment and research 2003;115():319-43.
2003: Paul G Corn; Matthew K Summers; Franz Fogt; Arvind K Virmani; Adi F Gazdar; Thanos D Halazonetis; Wafik S El-Deiry
Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.
Carcinogenesis 2003;24(1):47-51.
2003: Barbara G Campling; Wafik S El-Deiry
Clinical implications of p53 mutations in lung cancer.
Methods in molecular medicine 2003;75():53-77.
2002: Peiwen Fei; Eric J Bernhard; Wafik S El-Deiry
Tissue-specific induction of p53 targets in vivo.
Cancer research 2002;62(24):7316-27.
2002: Ravichandran N Venkataramani; Timothy K MacLachlan; Xiaomei Chai; Wafik S El-Deiry; Ronen Marmorstein
Structure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity.
The Journal of biological chemistry 2002;277(50):48827-33.
2002: Nesrin Ozören; Wafik S El-Deiry
Heat shock protects HCT116 and H460 cells from TRAIL-induced apoptosis.
Experimental cell research 2002;281(2):175-81.
2002: Nesrin Ozören; Wafik S El-Deiry
Defining characteristics of Types I and II apoptotic cells in response to TRAIL.
Neoplasia (New York, N.Y.) 2002;4(6):551-7.
2002: Joanna K Sax; Peiwen Fei; Maureen E Murphy; Eric J Bernhard; Stanley J Korsmeyer; Wafik S El-Deiry
BID regulation by p53 contributes to chemosensitivity.
Nature cell biology 2002;4(11):842-9.
2002: Wafik S El-Deiry
Transactivation of repair genes by BRCA1.
Cancer biology & therapy 2002;1(5):490-1.
2002: Adda Grimberg; Bingrong Liu; Peter Bannerman; Wafik S El-Deiry; Pinchas Cohen
IGFBP-3 mediates p53-induced apoptosis during serum starvation.
International journal of oncology 2002;21(2):327-35.
2002: Timothy K MacLachlan; Wafik S El-Deiry
Apoptotic threshold is lowered by p53 transactivation of caspase-6.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9492-7.
2002: Wafik S El-Deiry
Phenomenology and scientific progress.
Cancer biology & therapy 2002;1(4):436-7.
2002: Timothy K MacLachlan; Rishu Takimoto; Wafik S El-Deiry
BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets.
Molecular and cellular biology 2002;22(12):4280-92.
2002: Qin He; Dong Ik Lee; Rong Rong; Myounghee Yu; Xiuquan Luo; Michael Klein; Wafik S El-Deiry; Ying Huang; Arif Hussain; M Saeed Sheikh
Endoplasmic reticulum calcium pool depletion-induced apoptosis is coupled with activation of the death receptor 5 pathway.
Oncogene 2002;21(17):2623-33.
2002: Rishu Takimoto; Timothy K MacLachlan; David T Dicker; Yoshiro Niitsu; Toshio Mori; Wafik S El-Deiry
BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation.
Cancer biology & therapy 2002;1(2):177-86.
2002: Allyson M Campbell; Barbara G Campling; Kenneth M Algazy; Wafik S El-Deiry
Clinical and molecular features of small cell lung cancer.
Cancer biology & therapy 2002;1(2):105-12.
2002: Joanna K Sax; Bipin C Dash; Rui Hong; David T Dicker; Wafik S El-Deiry
The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21 (WAF1/CIP1 expression).
Cell cycle (Georgetown, Tex.) 2002;1(1):90-6.
2002: Zhaoyu Jin; David T Dicker; Wafik S El-Deiry
Enhanced sensitivity of G1 arrested human cancer cells suggests a novel therapeutic strategy using a combination of simvastatin and TRAIL.
Cell cycle (Georgetown, Tex.) 2002;1(1):82-9.
2002: Rishu Takimoto; Wenge Wang; David T Dicker; Farzan Rastinejad; Joseph P Lyssikatos; Wafik S El-Deiry
The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein.
Cancer biology & therapy 2002;1(1):47-55.
2002: Paul G Corn; Wafik S El-Deiry
Derangement of growth and differentiation control in oncogenesis.
BioEssays : news and reviews in molecular, cellular and developmental biology 2002;24(1):83-90.
2001: Ting Wang; T Kobayashi; R Takimoto; A E Denes; E L Snyder; Wafik S El-Deiry; Rainer K Brachmann
hADA3 is required for p53 activity.
The EMBO journal 2001;20(22):6404-13.
2001: Wafik S El-Deiry
Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling.
Cell death and differentiation 2001;8(11):1066-75.
2001: Hajime Higuchi; Steven F Bronk; Y Takikawa; Nathan W Werneburg; R Takimoto; Wafik S El-Deiry; Gregory J Gores
The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis.
The Journal of biological chemistry 2001;276(42):38610-8.
2001: Timothy F Burns; Wafik S El-Deiry
Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach.
The Journal of biological chemistry 2001;276(41):37879-86.
2001: Liang Qiao; Elaine Studer; K Leach; Robert McKinstry; Seema Gupta; Roy H Decker; R Kukreja; Kristoffer Valerie; Prakash S Nagarkatti; Wafik S El-Deiry; J Molkentin; Rupert K Schmidt-Ullrich; Paul B Fisher; Steven Grant; Phillip B Hylemon; Paul Dent
Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.
Molecular biology of the cell 2001;12(9):2629-45.
2001: Yasir Suliman; Oliver G Opitz; A Avadhani; T C Burns; Wafik S El-Deiry; D T Wong; Anil K Rustgi
p63 expression is associated with p53 loss in oral-esophageal epithelia of p53-deficient mice.
Cancer research 2001;61(17):6467-73.
2001: Timothy F Burns; Eric J Bernhard; Wafik S El-Deiry
Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo.
Oncogene 2001;20(34):4601-12.
2001: Qun Liu; Wafik S El-Deiry; Yair Gazitt
Additive effect of Apo2L/TRAIL and Adeno-p53 in the induction of apoptosis in myeloma cell lines.
Experimental hematology 2001;29(8):962-70.
2001: M J Fisher; A K Virmani; LI WU; Richard Aplenc; J C Harper; S M Powell; T R Rebbeck; David Sidransky; A F Gazdar; Wafik S El-Deiry
Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(6):1688-97.
2001: E Robert McDonald; Patricia C Chui; P F Martelli; David T Dicker; Wafik S El-Deiry
Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling.
The Journal of biological chemistry 2001;276(18):14939-45.
2001: E Robert McDonald; Wafik S El-Deiry
Checkpoint genes in cancer.
Annals of medicine 2001;33(2):113-22.
2001: Wafik S El-Deiry
Akt takes centre stage in cell-cycle deregulation.
Nature cell biology 2001;3(3):E71-3.
2001: G S Goldberg; Z Jin; H Ichikawa; A Naito; M Ohki; Wafik S El-Deiry; Hiroyuki Tsuda
Global effects of anchorage on gene expression during mammary carcinoma cell growth reveal role of tumor necrosis factor-related apoptosis-inducing ligand in anoikis.
Cancer research 2001;61(4):1334-7.
2001: Kunhong Kim; Rishu Takimoto; David T Dicker; Youhai Chen; Yair Gazitt; Wafik S El-Deiry
Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines.
International journal of oncology 2001;18(2):241-7.
2001: R Takimoto; Wafik S El-Deiry
DNA replication blockade impairs p53-transactivation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):781-3.
2001: Raymond De Meng; Wafik S El-Deiry
p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma.
Experimental cell research 2001;262(2):154-69.
2001: Rüdiger Göke; Alexandra Göke; Burkhard Göke; Wafik S El-Deiry; Youhai Chen
Pioglitazone inhibits growth of carcinoid cells and promotes TRAIL-induced apoptosis by induction of p21waf1/cip1.
Digestion 2001;64(2):75-80.
2000: M Stacey Ricci; Wafik S El-Deiry
Novel strategies for therapeutic design in molecular oncology using gene expression profiles.
Current opinion in molecular therapeutics 2000;2(6):682-90.
2000: T K MacLachlan; Wafik S El-Deiry
Pointing (zinc) fingers at BRCA1 targets.
Nature medicine 2000;6(12):1318-9.
2000: K O Mitchell; M Stacey Ricci; T Miyashita; David T Dicker; Zhaoyu Jin; J C Reed; Wafik S El-Deiry
Bax is a transcriptional target and mediator of c-myc-induced apoptosis.
Cancer research 2000;60(22):6318-25.
2000: N Ozoren; Kunhong Kim; Timothy F Burns; David T Dicker; A David Moscioni; Wafik S El-Deiry
The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand.
Cancer research 2000;60(22):6259-65.
2000: Timothy K MacLachlan; Bipin C Dash; David T Dicker; Wafik S El-Deiry
Repression of BRCA1 through a feedback loop involving p53.
The Journal of biological chemistry 2000;275(41):31869-75.
2000: Kapaettu Satyamoorthy; NH Chehab; M J Waterman; M C Lien; Wafik S El-Deiry; Meenhard Herlyn; Thanos D Halazonetis
Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(9):467-74.
2000: Wafik S El-Deiry
AACR - 91st meeting. Novel concepts and targets for therapeutic manipulation.
IDrugs : the investigational drugs journal 2000;3(7):717-8.
2000: Nesrin Ozören; M J Fisher; Kunhong Kim; CX Liu; Anna Genin; Y Shifman; David T Dicker; Nancy B Spinner; NA Lisitsyn; Wafik S El-Deiry
Homozygous deletion of the death receptor DR4 gene in a nasopharyngeal cancer cell line is associated with TRAIL resistance.
International journal of oncology 2000;16(5):917-25.
2000: E Robert McDonald; Wafik S El-Deiry
Cell cycle control as a basis for cancer drug development (Review).
International journal of oncology 2000;16(5):871-86.
2000: Rishu Takimoto; Wafik S El-Deiry
Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site.
Oncogene 2000;19(14):1735-43.
2000: Shi-qiong Xu; Wafik S El-Deiry
p21(WAF1/CIP1) inhibits initiator caspase cleavage by TRAIL death receptor DR4.
Biochemical and biophysical research communications 2000;269(1):179-90.
2000: Raymond De Meng; E Robert McDonald; M S Sheikh; A J Fornace; Wafik S El-Deiry
The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(2):130-44.
2000: Kunhong Kim; M J Fisher; Shi-qiong Xu; Wafik S El-Deiry
Molecular determinants of response to TRAIL in killing of normal and cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(2):335-46.
2000: Timothy K MacLachlan; K Somasundaram; Magdalene K Sgagias; Y Shifman; Ruth J Muschel; Kenneth H Cowan; Wafik S El-Deiry
BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression.
The Journal of biological chemistry 2000;275(4):2777-85.
2000: Jong Sung Park; S Boyer; K Mitchell; Donna Gilfor; Michael J Birrer; G Darlington; Wafik S El-Deiry; G L Firestone; K Munger; V Band; Paul B Fisher; Paul Dent
Expression of human papilloma virus E7 protein causes apoptosis and inhibits DNA synthesis in primary hepatocytes via increased expression of p21(Cip-1/WAF1/MDA6).
The Journal of biological chemistry 2000;275(1):18-28.
2000: Gen Sheng Wu; Kunhong Kim; Wafik S El-Deiry
KILLER/DR5, a novel DNA-damage inducible death receptor gene, links the p53-tumor suppressor to caspase activation and apoptotic death.
Advances in experimental medicine and biology 2000;465():143-51.
1999: K Somasundaram; Timothy K MacLachlan; Timothy F Burns; Magdalene K Sgagias; Kenneth H Cowan; Barbara L Weber; Wafik S El-Deiry
BRCA1 signals ARF-dependent stabilization and coactivation of p53.
Oncogene 1999;18(47):6605-14.
1999: Gen Sheng Wu; Timothy F Burns; E Robert McDonald; Raymond De Meng; Gary D Kao; Ruth J Muschel; T Yen; Wafik S El-Deiry
Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest.
Oncogene 1999;18(47):6411-8.
1999: S Song; Timothy K MacLachlan; Raymond De Meng; Wafik S El-Deiry
Comparative gene expression profiling in response to p53 in a human lung cancer cell line.
Biochemical and biophysical research communications 1999;264(3):891-5.
1999: Timothy K MacLachlan; Raymond De Meng; Wafik S El-Deiry
"p53: Twenty Years On" in Trieste, Italy, May 20-22, 1999.
Journal of cellular physiology 1999;181(2):371-4.
1999: Timothy F Burns; Wafik S El-Deiry
The p53 pathway and apoptosis.
Journal of cellular physiology 1999;181(2):231-9.
1999: Ninad Prabhu; K Somasundaram; H Tian; Greg H Enders; K Satyamoorthy; Meenhard Herlyn; Wafik S El-Deiry
The administration schedule of cyclin-dependent kinase inhibitor gene therapy and etoposide chemotherapy is a major determinant of cytotoxicity.
International journal of oncology 1999;15(2):209-16.
1999: MS Sheikh; Yanping Huang; E A Fernandez-Salas; Wafik S El-Deiry; H Friess; Sally A Amundson; Jing Yin; Meltzer Stephen J.; Nikki J Holbrook; Albert J Fornace
The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract.
Oncogene 1999;18(28):4153-9.
1999: Shi-Yong Sun; Ping Yue; Gen Sheng Wu; Wafik S El-Deiry; B Shroot; Waun Ki Hong; Reuben Lotan
Implication of p53 in growth arrest and apoptosis induced by the synthetic retinoid CD437 in human lung cancer cells.
Cancer research 1999;59(12):2829-33.
1999: Gen Sheng Wu; Timothy F Burns; Yi Zhan; Emad S Alnemri; Wafik S El-Deiry
Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor.
Cancer research 1999;59(12):2770-5.
1999: Weng-Lang Yang; Y X Zeng; Wafik S El-Deiry; K Nason-Burchenal; Ethan Dmitrovsky; Khew-Voon Chin
Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
Molecular cell biology research communications : MCBRC 1999;1(2):125-31.
1999: Jayashree Mitra; Charlotte Y Dai; K Somasundaram; Wafik S El-Deiry; K Satyamoorthy; Meenhard Herlyn; Greg H Enders
Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a).
Molecular and cellular biology 1999;19(5):3916-28.
1999: Shi-Yong Sun; Ping Yue; Gen Sheng Wu; Wafik S El-Deiry; B Shroot; Waun Ki Hong; Reuben Lotan
Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells.
Oncogene 1999;18(14):2357-65.
1999: K O Mitchell; Wafik S El-Deiry
Overexpression of c-Myc inhibits p21WAF1/CIP1 expression and induces S-phase entry in 12-O-tetradecanoylphorbol-13-acetate (TPA)-sensitive human cancer cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(4):223-30.
1999: Raymond De Meng; P Phillips; Wafik S El-Deiry
p53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin.
International journal of oncology 1999;14(1):5-14.
1998: Rajani Ravi; B Mookerjee; Yvette van Hensbergen; G C Bedi; Antonio Giordano; Wafik S El-Deiry; Ephraim J Fuchs; Atul Bedi
p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300.
Cancer research 1998;58(20):4531-6.
1998: Sara I Pai; Gen Sheng Wu; N Ozören; LI WU; Jin Jen; David Sidransky; Wafik S El-Deiry
Rare loss-of-function mutation of a death receptor gene in head and neck cancer.
Cancer research 1998;58(16):3513-8.
1998: Ninad Prabhu; K Somasundaram; K Satyamoorthy; Meenhard Herlyn; Wafik S El-Deiry
p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells.
International journal of oncology 1998;13(1):5-9.
1998: Patrick Williams; Wafik S El-Deiry; WALTER RUSH; Donald G Guinee; Andrew N Freedman; Neil E Caporaso; Judith A Welsh; Raymond T Jones; Andrew Borkowski; William D Travis; MV Fleming; Victor Trastek; Peter C Pairolero; Henry D Tazelaar; David E Midthun; James R Jett; Lance A Liotta; Curtis C Harris
p21waf1/cip1 and transforming growth factor beta 1 protein expression correlate with survival in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(6):1499-506.
1998: B Tong; H Leighton Grimes; T Y Yang; Susan E Bear; Z Qin; K Du; Wafik S El-Deiry; Philip Tsichlis
The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation.
Molecular and cellular biology 1998;18(5):2462-73.
1998: Gen Sheng Wu; P Saftig; C Peters; Wafik S El-Deiry
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.
Oncogene 1998;16(17):2177-83.
1998: MS Sheikh; Timothy F Burns; Yanping Huang; Gen Sheng Wu; Sally A Amundson; K S Brooks; Albert J Fornace; Wafik S El-Deiry
p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha.
Cancer research 1998;58(8):1593-8.
1998: Hongtao Zhang; K Somasundaram; Y Peng; H Tian; H Zhang; D Bi; Barbara L Weber; Wafik S El-Deiry
BRCA1 physically associates with p53 and stimulates its transcriptional activity.
Oncogene 1998;16(13):1713-21.
1998: Wen-Chen Yeh; J L Pompa; Mila E McCurrach; HB Shu; Andrew Elia; Arda Shahinian; M Ng; Andrew Wakeham; W Khoo; K Mitchell; Wafik S El-Deiry; Scott W Lowe; David V Goeddel; Tak W Mak
FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.
Science (New York, N.Y.) 1998;279(5358):1954-8.
1998: Mikhail V Blagosklonny; Wafik S El-Deiry
Acute overexpression of wt p53 facilitates anticancer drug-induced death of cancer and normal cells.
International journal of cancer. Journal international du cancer 1998;75(6):933-40.
1998: M S Gee; Christopher J Sarkisian; Wafik S El-Deiry
Identification of a novel AP-2 consensus DNA binding site.
Biochemical and biophysical research communications 1998;243(1):307-16.
1998: Raymond De Meng; Wafik S El-Deiry
Tumor suppressor gene therapy for cancer: from the bench to the clinic.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 1998;1(3):205-10.
1998: Wafik S El-Deiry
Regulation of p53 downstream genes.
Seminars in cancer biology 1998;8(5):345-57.
1998: Raymond De Meng; H Shih; Ninad Prabhu; Donna L George; Wafik S El-Deiry
Bypass of abnormal MDM2 inhibition of p53-dependent growth suppression.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(1):251-9.
1998: Wafik S El-Deiry
p21/p53, cellular growth control and genomic integrity.
Current topics in microbiology and immunology 1998;227():121-37.
1997: Gen Sheng Wu; Timothy F Burns; E Robert McDonald; W Jiang; Raymond De Meng; I D Krantz; Gary D Kao; D D Gan; J Y Zhou; Ruth J Muschel; S R Hamilton; Nancy B Spinner; S Markowitz; G Wu; Wafik S El-Deiry
KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene.
Nature genetics 1997;17(2):141-3.
1997: K Somasundaram; Hongtao Zhang; YX Zeng; Y Houvras; Y Peng; H Zhang; Gen Sheng Wu; Jonathan D Licht; Barbara L Weber; Wafik S El-Deiry
Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.
Nature 1997;389(6647):187-90.
1997: YX Zeng; K Somasundaram; Ninad Prabhu; R Krishnadasan; Wafik S El-Deiry
Detection and analysis of living, growth-inhibited mammalian cells following transfection.
BioTechniques 1997;23(1):88, 90, 92, 94.
1997: K Somasundaram; Wafik S El-Deiry
Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region.
Oncogene 1997;14(9):1047-57.
1997: L Shick; J H Carman; John K Choi; K Somasundaram; M Burrell; David E Hill; YX Zeng; Yihan Wang; K G Wiman; KE Salhany; Tom Kadesch; John G Monroe; L A Donehower; Wafik S El-Deiry
Decreased immunoglobulin deposition in tumors and increased immature B cells in p53-null mice.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(2):121-31.
1997: M V Blagosklonny; Ninad Prabhu; Wafik S El-Deiry
Defects in p21WAF1/CIP1, Rb, and c-myc signaling in phorbol ester-resistant cancer cells.
Cancer research 1997;57(2):320-5.
1997: Wafik S El-Deiry
Role of oncogenes in resistance and killing by cancer therapeutic agents.
Current opinion in oncology 1997;9(1):79-87.
1997: YX Zeng; K Somasundaram; Wafik S El-Deiry
AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression.
Nature genetics 1997;15(1):78-82.
1997: M V Blagosklonny; P Giannakakou; Wafik S El-Deiry; D G Kingston; P I Higgs; L Neckers; T Fojo
Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death.
Cancer research 1997;57(1):130-5.
1996: Mikhail V Blagosklonny; Gen Sheng Wu; S Omura; Wafik S El-Deiry
Proteasome-dependent regulation of p21WAF1/CIP1 expression.
Biochemical and biophysical research communications 1996;227(2):564-9.
1996: S P Dowell; E McGoogan; S M Picksley; Wafik S El-Deiry; Bert Vogelstein; Peter A Hall
Expression of p21waf1/Cip1, MDM2 and p53 in vivo: analysis of cytological preparations.
Cytopathology : official journal of the British Society for Clinical Cytology 1996;7(5):340-51.
1996: Andrei L Gartel; Michael Serfas; M Gartel; E Goufman; Gen Sheng Wu; Wafik S El-Deiry; Angela L Tyner
p21 (WAF1/CIP1) expression is induced in newly nondividing cells in diverse epithelia and during differentiation of the Caco-2 intestinal cell line.
Experimental cell research 1996;227(2):171-81.
1996: Mikhail V Blagosklonny; Wafik S El-Deiry
In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug.
International journal of cancer. Journal international du cancer 1996;67(3):386-92.
1996: Ninad Prabhu; Mikhail V Blagosklonny; YX Zeng; Gen Sheng Wu; Todd Waldman; Wafik S El-Deiry
Suppression of cancer cell growth by adenovirus expressing p21(WAF1/CIP1) deficient in PCNA interaction.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(7):1221-9.
1996: Victor E Velculescu; Wafik S El-Deiry
Biological and clinical importance of the p53 tumor suppressor gene.
Clinical chemistry 1996;42(6 Pt 1):858-68.
1996: E Robert McDonald; Gen Sheng Wu; Todd Waldman; Wafik S El-Deiry
Repair Defect in p21 WAF1/CIP1 -/- human cancer cells.
Cancer research 1996;56(10):2250-5.
1996: YX Zeng; Wafik S El-Deiry
Regulation of p21WAF1/CIP1 expression by p53-independent pathways.
Oncogene 1996;12(7):1557-64.
1996: Gen Sheng Wu; Wafik S El-Deiry
Apoptotic death of tumor cells correlates with chemosensitivity, independent of p53 or bcl-2.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(4):623-33.
1996: IO Baas; G Johan A Offerhaus; Wafik S El-Deiry; Tzyy-choou Wu; Grover M Hutchins; Edward K Kasper; K L Baughman; WM BAUMGARTNER; Chuang-Jiun Chiou; Gary S Hayward; Ralph Hruban
The WAF1-mediated p53 growth-suppressor pathway is intact in the coronary arteries of heart transplant recipients.
Human pathology 1996;27(4):324-9.
1995: Atul Bedi; Jamie P Barber; G C Bedi; Wafik S El-Deiry; David Sidransky; Milada S Vala; A J Akhtar; John Hilton; Richard J Jones
BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: a mechanism of resistance to multiple anticancer agents.
Blood 1995;86(3):1148-58.
1995: Wafik S El-Deiry; T Tokino; Todd Waldman; J D Oliner; Victor E Velculescu; M Burrell; David E Hill; E Healy; J L Rees; Stanley R Hamilton
Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.
Cancer research 1995;55(13):2910-9.
1995: M M Wales; M A Biel; Wafik S El-Deiry; Barry D Nelkin; Jean-Pierre J Issa; W K Cavenee; S J Kuerbitz; Stephen B Baylin
p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3.
Nature medicine 1995;1(6):570-7.
1995: L T da Costa; B Liu; Wafik S El-Deiry; S R Hamilton; Kenneth W Kinzler; Bert Vogelstein; S Markowitz; James Willson; ALBERT DE LA CHAPELLE; K M Downey
Polymerase delta variants in RER colorectal tumours.
Nature genetics 1995;9(1):10-1.
1994: Masaaki Shiohara; Wafik S El-Deiry; M Wada; Tsuyoshi Nakamaki; Seisho Takeuchi; Rong Yang; D L Chen; Bert Vogelstein; H Phillip Koeffler
Absence of WAF1 mutations in a variety of human malignancies.
Blood 1994;84(11):3781-4.
1994: S Fan; Wafik S El-Deiry; I Bae; J Freeman; D Jondle; Kishor Bhatia; Albert J Fornace; Ian Magrath; Kurt W Kohn; Patrick M O'Connor
p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.
Cancer research 1994;54(22):5824-30.
1994: T Tokino; S Thiagalingam; Wafik S El-Deiry; Todd Waldman; Kenneth W Kinzler; Bert Vogelstein
p53 tagged sites from human genomic DNA.
Human molecular genetics 1994;3(9):1537-42.
1994: J A Pietenpol; T Tokino; S Thiagalingam; Wafik S El-Deiry; Kenneth W Kinzler; Bert Vogelstein
Sequence-specific transcriptional activation is essential for growth suppression by p53.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):1998-2002.
1994: Wafik S El-Deiry; J W Harper; Patrick M O'Connor; Victor E Velculescu; Shilpy Sharma; J Jackman; J A Pietenpol; M Burrell; David E Hill; Y Wang
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
Cancer research 1994;54(5):1169-74.
1993: Wafik S El-Deiry; T Tokino; Victor E Velculescu; D B Levy; R Parsons; Jeffrey M. Trent; D Lin; W E Mercer; Kenneth W Kinzler; Bert Vogelstein
WAF1, a potential mediator of p53 tumor suppression.
Cell 1993;75(4):817-25.
1992: Michael B Kastan; Qimin Zhan; Wafik S El-Deiry; France Carrier; Tyler Jacks; W V Walsh; B S Plunkett; Bert Vogelstein; Albert J Fornace
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.
Cell 1992;71(4):587-97.
1992: Ray-Whay Chiu Yen; Paula M Vertino; Barry D Nelkin; J J Yu; Wafik S El-Deiry; A Cumaraswamy; G G Lennon; Barbara J Trask; P Celano; Stephen B Baylin
Isolation and characterization of the cDNA encoding human DNA methyltransferase.
Nucleic acids research 1992;20(9):2287-91.
1992: Wafik S El-Deiry; Scott E Kern; J A Pietenpol; Kenneth W Kinzler; Bert Vogelstein
Definition of a consensus binding site for p53.
Nature genetics 1992;1(1):45-9.
1991: Wafik S El-Deiry; Barry D Nelkin; P Celano; Ray-Whay Chiu Yen; J P Falco; S R Hamilton; Stephen B Baylin
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3470-4.
1988: Wafik S El-Deiry; Antero G So; K M Downey
Mechanisms of error discrimination by Escherichia coli DNA polymerase I.
Biochemistry 1988;27(2):546-53.
1984: Wafik S El-Deiry; K M Downey; Antero G So
Molecular mechanisms of manganese mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(23):7378-82.
1982: P Cupo; Wafik S El-Deiry; Philip Whitney; William Awad
Stability of acetylated and superguanidinated chymotrypsinogens.
Archives of biochemistry and biophysics 1982;216(2):600-4.
1980: P Cupo; Wafik S El-Deiry; Philip Whitney; William Awad
Stabilization of proteins by guanidination.
The Journal of biological chemistry 1980;255(22):10828-33.