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Wafik El-Deiry
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32
Dicker, David
17
Wang, Wenge
17
Wu, Gen Sheng
16
Burns, Timothy
12
Kim, Seok-Hyun
12
McDonald, Robert
11
MacLachlan, Timothy
11
Somasundaram, K
11
Herlyn, Meenhard
10
Finnberg, Niklas
9
Ricci, Stacey
9
Wang, Shulin
9
Meng, Raymond De
8
Vogelstein, Bert
8
Jin, Zhaoyu
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All Publications
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2009: Ide Takao; Brown-Endres Lauren; Chu Kiki; Ongusaha Pat P; Ohtsuka Takao; El-Deiry Wafik S; Aaronson Stuart A; Lee Sam W
GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress.
Molecular cell 2009;36(3):379-92.
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2009: Zhou Lanlan; El-Deiry Wafik S
Multispectral fluorescence imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(10):1563-6.
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2009: Wambi Chris O; Sanzari Jenine K; Sayers Carly M; Nuth Manunya; Zhou Zhaozong; Davis James; Finnberg Niklas; Lewis-Wambi Joan S; Ware Jeffrey H; El-Deiry Wafik S; Kennedy Ann R
Protective effects of dietary antioxidants on proton total-body irradiation-mediated hematopoietic cell and animal survival.
Radiation research 2009;172(2):175-86.
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2009: Galluzzi L; Aaronson S A; Abrams J; Alnemri E S; Andrews D W; Baehrecke E H; Bazan N G; Blagosklonny M V; Blomgren K; Borner C; Bredesen D E; Brenner C; Castedo M; Cidlowski J A; Ciechanover A; Cohen G M; De Laurenzi V; De Maria R; Deshmukh M; Dynlacht B D; El-Deiry W S; Flavell R A; Fulda S; Garrido C; Golstein P; Gougeon M-L; Green D R; Gronemeyer H; Hajnóczky G; Hardwick J M; Hengartner M O; Ichijo H; Jäättelä M; Kepp O; Kimchi A; Klionsky D J; Knight R A; Kornbluth S; Kumar S; Levine B; Lipton S A; Lugli E; Madeo F; Malomi W; Marine J-C W; Martin S J; Medema J P; Mehlen P; Melino G; Moll U M; Morselli E; Nagata S; Nicholson D W; Nicotera P; Nuñez G; Oren M; Penninger J; Pervaiz S; Peter M E; Piacentini M; Prehn J H M; Puthalakath H; Rabinovich G A; Rizzuto R; Rodrigues C M P; Rubinsztein D C; Rudel T; Scorrano L; Simon H-U; Steller H; Tschopp J; Tsujimoto Y; Vandenabeele P; Vitale I; Vousden K H; Youle R J; Yuan J; Zhivotovsky B; Kroemer G
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.
Cell death and differentiation 2009;16(8):1093-107.
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2009: Hart Lori S; El-Deiry Wafik S
Cell death: a new Par-4 the TRAIL.
Cell 2009;138(2):220-2.
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2009: Lu Chao; El-Deiry Wafik S
Targeting p53 for enhanced radio- and chemo-sensitivity.
Apoptosis : an international journal on programmed cell death 2009;14(4):597-606.
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2009: Kroemer G; Galluzzi L; Vandenabeele P; Abrams J; Alnemri E S; Baehrecke E H; Blagosklonny M V; El-Deiry W S; Golstein P; Green D R; Hengartner M; Knight R A; Kumar S; Lipton S A; Malorni W; Nuñez G; Peter M E; Tschopp J; Yuan J; Piacentini M; Zhivotovsky B; Melino G;
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009.
Cell death and differentiation 2009;16(1):3-11.
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2008: Lu Chao; Wang Wenge; El-Deiry Wafik S
Non-genotoxic anti-neoplastic effects of ellipticine derivative NSC176327 in p53-deficient human colon carcinoma cells involve stimulation of p73.
Cancer biology & therapy 2008;7(12):2039-46.
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2008: Plastaras John P; Dorsey Jay F; Carroll Kristina; Kim Seok-Hyun; Birnbaum Morris J; El-Deiry Wafik S
Role of PI3K/Akt signaling in TRAIL- and radiation-induced gastrointestinal apoptosis.
Cancer biology & therapy 2008;7(12):2047-53.
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2008: Kuribayashi Kageaki; Krigsfeld Gabriel; Wang Wenge; Xu Jing; Mayes Patrick A; Dicker David T; Wu Gen Sheng; El-Deiry Wafik S
TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death.
Cancer biology & therapy 2008;7(12):2034-8.
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2008: Finnberg Niklas; Wambi Chris; Ware Jeffrey H; Kennedy Ann R; El-Deiry Wafik S
Gamma-radiation (GR) triggers a unique gene expression profile associated with cell death compared to proton radiation (PR) in mice in vivo.
Cancer biology & therapy 2008;7(12):2023-33.
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2008: Bassett Emily A; Wang Wenge; Rastinejad Farzan; El-Deiry Wafik S
Structural and functional basis for therapeutic modulation of p53 signaling.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(20):6376-86.
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2008: Mayes Patrick; Dicker David; Liu Yingqiu; El-Deiry Wafik
Noninvasive vascular imaging in fluorescent tumors using multispectral unmixing.
BioTechniques 2008;45(4):459-60, 461-4.
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2008: Hart Lori S; El-Deiry Wafik S
Invincible, but not invisible: imaging approaches toward in vivo detection of cancer stem cells.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(17):2901-10.
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2008: Finnberg Niklas; El-Deiry Wafik S
TRAIL death receptors as tumor suppressors and drug targets.
Cell cycle (Georgetown, Tex.) 2008;7(11):1525-8.
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2008: Noma Kazuhiro; Smalley Keiran S M; Lioni Mercedes; Naomoto Yoshio; Tanaka Noriaki; El-Deiry Wafik; King Alastair J; Nakagawa Hiroshi; Herlyn Meenhard
The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis.
Gastroenterology 2008;134(7):1981-93.
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2008: Kim Mijin; Liao Jessica; Dowling Melissa L; Voong K Ranh; Parker Sharon E; Wang Shulin; El-Deiry Wafik S; Kao Gary D
TRAIL inactivates the mitotic checkpoint and potentiates death induced by microtubule-targeting agents in human cancer cells.
Cancer research 2008;68(9):3440-9.
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2008: Liao Wentao; Xiao Qi; Tchikov Vladimir; Fujita Ken-ichi; Yang Wensheng; Wincovitch Stephen; Garfield Susan; Conze Dietrich; El-Deiry Wafik S; Schütze Stefan; Srinivasula Srinivasa M
CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation.
Current biology : CB 2008;18(9):641-9.
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2008: Kim Seok-Hyun; Ricci M Stacey; El-Deiry Wafik S
Mcl-1: a gateway to TRAIL sensitization.
Cancer research 2008;68(7):2062-4.
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2008: Yang Wensheng; Dicker David T; Chen Jiandong; El-Deiry Wafik S
CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2.
Cell cycle (Georgetown, Tex.) 2008;7(5):670-82.
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2008: Yang Wensheng; Dolloff Nathan G; El-Deiry Wafik S
ERK and MDM2 prey on FOXO3a.
Nature cell biology 2008;10(2):125-6.
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2008: Laguinge Luciana M; Samara Raed N; Wang Wenge; El-Deiry Wafik S; Corner Georgia; Augenlicht Leonard; Mishra Lopa; Jessup J Milburn
DR5 receptor mediates anoikis in human colorectal carcinoma cell lines.
Cancer research 2008;68(3):909-17.
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2008: Finnberg Niklas; Klein-Szanto Andres J P; El-Deiry Wafik S
TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis.
The Journal of clinical investigation 2008;118(1):111-23.
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2008: Wang Wenge; El-Deiry Wafik S
Restoration of p53 to limit tumor growth.
Current opinion in oncology 2008;20(1):90-6.
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2008: Kuribayashi Kageaki; Finnberg Niklas; El-Deiry Wafik S
Studying p53-dependent cell death in vitro and in vivo.
Methods in enzymology 2008;446():159-73.
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2008: Kuribayashi Kageaki; El-Deiry Wafik S
Regulation of programmed cell death by the p53 pathway.
Advances in experimental medicine and biology 2008;615():201-21.
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2007: Corn Paul G; El-Deiry Wafik S
Microarray analysis of p53-dependent gene expression in response to hypoxia and DNA damage.
Cancer biology & therapy 2007;6(12):1858-66.
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2007: El-Deiry Wafik S
Targeting mutant p53 shows promise for sunscreens and skin cancer.
The Journal of clinical investigation 2007;117(12):3658-60.
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2007: Yang Wensheng; El-Deiry Wafik S
CARPs are E3 ligases that target apical caspases and p53.
Cancer biology & therapy 2007;6(11):1676-83.
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2007: Okawa Takaomi; Michaylira Carmen Z; Kalabis Jiri; Stairs Douglas B; Nakagawa Hiroshi; Andl Claudia D; Johnstone Cameron N; Klein-Szanto Andres J; El-Deiry Wafik S; Cukierman Edna; Herlyn Meenhard; Rustgi Anil K
The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation.
Genes & development 2007;21(21):2788-803.
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2007: Maniar Tapan N; Braunstein Inbal; Keefe Stephen; Hussen Sofia; Abrams Tara; De Michele Angela; El-Deiry Wafik S
Childhood ALL and second neoplasms.
Cancer biology & therapy 2007;6(10):1525-31.
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2007: Wang Shulin; Mintz Akiva; Mochizuki Kenjiro; Dorsey Jay F; Ackermann Joseph M; Alavi Abass; El-Deiry Wafik S
Multimodality optical imaging and 18F-FDG uptake in wild-type p53-containing and p53-null human colon tumor xenografts.
Cancer biology & therapy 2007;6(10):1649-53.
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2007: Matthew Elizabeth M; Yen Timothy J; Dicker David T; Dorsey Jay F; Yang Wensheng; Navaraj Arunasalam; El-Deiry Wafik S
Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells.
Cell cycle (Georgetown, Tex.) 2007;6(20):2571-8.
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2007: Tavaluc Raluca T; Hart Lori S; Dicker David T; El-Deiry Wafik S
Effects of low confluency, serum starvation and hypoxia on the side population of cancer cell lines.
Cell cycle (Georgetown, Tex.) 2007;6(20):2554-62.
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2007: Dicker David T; Lerner Jeremy M; El-Deiry Wafik S
Hyperspectral image analysis of live cells in various cell cycle stages.
Cell cycle (Georgetown, Tex.) 2007;6(20):2563-70.
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2007: Plastaras John P; Kim Seok-Hyun; Liu Yingqiu Y; Dicker David T; Dorsey Jay F; McDonough James; Cerniglia George; Rajendran Ramji R; Gupta Anjali; Rustgi Anil K; Diehl J Alan; Smith Charles D; Flaherty Keith T; El-Deiry Wafik S
Cell cycle dependent and schedule-dependent antitumor effects of sorafenib combined with radiation.
Cancer research 2007;67(19):9443-54.
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2007: Sussman Robyn T; Ricci M Stacey; Hart Lori S; Sun Shi Yong; El-Deiry Wafik S
Chemotherapy-resistant side-population of colon cancer cells has a higher sensitivity to TRAIL than the non-SP, a higher expression of c-Myc and TRAIL-receptor DR4.
Cancer biology & therapy 2007;6(9):1490-5.
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2007: Ricci M Stacey; Kim Seok-Hyun; Ogi Kazuhiro; Plastaras John P; Ling Jianhua; Wang Wenge; Jin Zhaoyu; Liu Yingqiu Y; Dicker David T; Chiao Paul J; Flaherty Keith T; Smith Charles D; El-Deiry Wafik S
Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death.
Cancer cell 2007;12(1):66-80.
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2007: Takaoka Munenori; Kim Seok-Hyun; Okawa Takaomi; Michaylira Carmen Z; Stairs Douglas B; Johnstone Cameron N; Andl Claudia D; Rhoades Ben; Lee James J; Klein-Szanto Andres J P; El-Deiry Wafik S; Nakagawa Hiroshi
IGFBP-3 regulates esophageal tumor growth through IGF-dependent and independent mechanisms.
Cancer biology & therapy 2007;6(4):534-40.
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2007: Oyama K; Okawa T; Nakagawa H; Takaoka M; Andl C D; Kim S-H; Klein-Szanto A; Diehl J A; Herlyn M; El-Deiry W; Rustgi A K
AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture.
Oncogene 2007;26(16):2353-64.
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2007: Tumeh Paul C; Lerner Jeremy M; Dicker David T; El-Deiry Wafik S
Differentiation of vascular and non-vascular skin spectral signatures using in vivo hyperspectral radiometric imaging: implications for monitoring angiogenesis.
Cancer biology & therapy 2007;6(3):447-53.
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2007: Lioni Mercedes; Brafford Patricia; Andl Claudia; Rustgi Anil; El-Deiry Wafik; Herlyn Meenhard; Smalley Keiran S M
Dysregulation of claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells.
The American journal of pathology 2007;170(2):709-21.
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2007: Yang Wensheng; Rozan Laura M; McDonald E Robert; Navaraj Arunasalam; Liu Jue Judy; Matthew Elizabeth M; Wang Wenge; Dicker David T; El-Deiry Wafik S
CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation.
The Journal of biological chemistry 2007;282(5):3273-81.
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2007: Rozan L M; El-Deiry W S
p53 downstream target genes and tumor suppression: a classical view in evolution.
Cell death and differentiation 2007;14(1):3-9.
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2007: Scata Kimberly A; El-Deiry Wafik S
p53, BRCA1 and breast Cancer chemoresistance.
Advances in experimental medicine and biology 2007;608():70-86.
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2007: Kelloff Gary J; Sullivan Daniel C; Baker Houston; Clarke Lawrence P; Nordstrom Robert; Tatum James L; Dorfman Gary S; Jacobs Paula; Berg Christine D; Pomper Martin G; Birrer Michael J; Tempero Margaret; Higley Howard R; Petty Brenda Gumbs; Sigman Caroline C; Maley Carlo; Sharma Prateek; Wax Adam; Ginsberg Gregory G; Dannenberg Andrew J; Hawk Ernest T; Messing Edward M; Grossman H Barton; Harisinghani Mukesh; Bigio Irving J; Griebel Donna; Henson Donald E; Fabian Carol J; Ferrara Katherine; Fantini Sergio; Schnall Mitchell D; Zujewski Jo Anne; Hayes Wendy; Klein Eric A; DeMarzo Angelo; Ocak Iclal; Ketterling Jeffrey A; Tempany Clare; Shtern Faina; Parnes Howard L; Gomez Jorge; Srivastava Sudhir; Szabo Eva; Lam Stephen; Seibel Eric J; Massion Pierre; McLennan Geoffrey; Cleary Kevin; Suh Robert; Burt Randall W; Pfeiffer Ruth M; Hoffman John M; Roy Hemant K; Wang Thomas; Limburg Paul J; El-Deiry Wafik S; Papadimitrakopoulou Vali; Hittelman Walter N; MacAulay Calum; Veltri Robert W; Solomon Diane; Jeronimo Jose; Richards-Kortum Rebecca; Johnson Karen A; Viner Jaye L; Stratton Steven P; Rajadhyaksha Milind; Dhawan Atam;
Workshop on imaging science development for cancer prevention and preemption.
Cancer biomarkers : section A of Disease markers 2007;3(1):1-33.
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2006: Kim Seok-Hyun; Nakagawa Hiroshi; Navaraj Arunasalam; Naomoto Yoshio; Klein-Szanto Andres J P; Rustgi Anil K; El-Deiry Wafik S
Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous Ras.
Cancer research 2006;66(21):10415-24.
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2006: Jin Zhaoyu; El-Deiry Wafik S
Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis.
Molecular and cellular biology 2006;26(21):8136-48.
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2006: Grimberg Adda; Coleman Carrie M; Shi Zonggao; Burns Timothy F; MacLachlan Timothy K; Wang Wenge; El-Deiry Wafik S
Insulin-like growth factor factor binding protein-2 is a novel mediator of p53 inhibition of insulin-like growth factor signaling.
Cancer biology & therapy 2006;5(10):1408-14.
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2006: Scata Kimberly A; El-Deiry Wafik S
Taming NEMO to slay cancer cells.
Cancer biology & therapy 2006;5(9):1096-7.
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2006: Rozan Laura M; El-Deiry Wafik S
Identification and characterization of proteins interacting with Traf4, an enigmatic p53 target.
Cancer biology & therapy 2006;5(9):1228-35.
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2006: Dicker David T; Lerner Jeremy; Van Belle Pat; Barth Stephen F; Guerry Dupont; Herlyn Meenhard; Elder David E; El-Deiry Wafik S
Differentiation of normal skin and melanoma using high resolution hyperspectral imaging.
Cancer biology & therapy 2006;5(8):1033-8.
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2006: Tang Jun; Qu Li-Ke; Zhang Jianke; Wang Wenge; Michaelson Jennifer S; Degenhardt Yan Y; El-Deiry Wafik S; Yang Xiaolu
Critical role for Daxx in regulating Mdm2.
Nature cell biology 2006;8(8):855-62.
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2006: Mayes Patrick A; El-Deiry Wafik S
The complementary roles of the extrinsic and intrinsic apoptotic pathways in promoting the death of cancer cells.
Cancer journal (Sudbury, Mass.) 2006;12(4):247-9.
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2006: Kuribayashi Kageaki; Mayes Patrick A; El-Deiry Wafik S
What are caspases 3 and 7 doing upstream of the mitochondria?
Cancer biology & therapy 2006;5(7):763-5.
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2006: Finnberg Niklas; El-Deiry Wafik S
Selective TRAIL-induced apoptosis in dysplastic neoplasia of the colon may lead to new neoadjuvant or adjuvant therapies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 1):4132-6.
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2006: Wang Shulin; El-Deiry Wafik S
p73 or p53 directly regulates human p53 transcription to maintain cell cycle checkpoints.
Cancer research 2006;66(14):6982-9.
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2006: Wang Wenge; Kim Seok-Hyun; El-Deiry Wafik S
Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):11003-8.
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2006: El-Deiry Wafik S; Sigman Caroline C; Kelloff Gary J
Imaging and oncologic drug development.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(20):3261-73.
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2006: El-Deiry Wafik S
Lobbying Congress to make cancer funding a priority: what scientists can do.
Cancer biology & therapy 2006;5(5):467-9.
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2006: Takaoka Munenori; Smith Caitlin E; Mashiba Michael K; Okawa Takaomi; Andl Claudia D; El-Deiry Wafik S; Nakagawa Hiroshi
EGF-mediated regulation of IGFBP-3 determines esophageal epithelial cellular response to IGF-I.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(2):G404-16.
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2005: Navaraj Arunasalam; Mori Toshio; El-Deiry Wafik S
Cooperation between BRCA1 and p53 in repair of cyclobutane pyrimidine dimers.
Cancer biology & therapy 2005;4(12):1409-14.
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2005: Corn Paul G; Ricci M Stacey; Scata Kimberly A; Arsham Andrew M; Simon M Celeste; Dicker David T; El-Deiry Wafik S
Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis.
Cancer biology & therapy 2005;4(11):1285-94.
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2005: Kroemer G; El-Deiry W S; Golstein P; Peter M E; Vaux D; Vandenabeele P; Zhivotovsky B; Blagosklonny M V; Malorni W; Knight R A; Piacentini M; Nagata S; Melino G;
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death.
Cell death and differentiation 2005;12 Suppl 2():1463-7.
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2005: Wang Jian; Devgan Vikram; Corrado Marcella; Prabhu Nita S; El-Deiry Wafik S; Riccardi Carlo; Pandolfi Pier Paolo; Missero Caterina; Dotto G Paolo
Glucocorticoid-induced tumor necrosis factor receptor is a p21Cip1/WAF1 transcriptional target conferring resistance of keratinocytes to UV light-induced apoptosis.
The Journal of biological chemistry 2005;280(45):37725-31.
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2005: Mayes Patrick A; Campbell Latoya; Ricci M Stacey; Plastaras John P; Dicker David T; El-Deiry Wafik S
Modulation of TRAIL-induced tumor cell apoptosis in a hypoxic environment.
Cancer biology & therapy 2005;4(10):1068-74.
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2005: Finnberg Niklas; Kim Seok-Hyun; Furth Emma E; Liu Jue Judy; Russo Pierre; Piccoli David A; Grimberg Adda; El-Deiry Wafik S
Non-invasive fluorescence imaging of cell death in fresh human colon epithelia treated with 5-Fluorouracil, CPT-11 and/or TRAIL.
Cancer biology & therapy 2005;4(9):937-42.
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2005: Dicker David T; Kim Seok-Hyun; Jin Zhaoyu; El-Deiry Wafik S
Heterogeneity in non-invasive detection of apoptosis among human tumor cell lines using annexin-V tagged with EGFP or Qdot-705.
Cancer biology & therapy 2005;4(9):1014-7.
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2005: Wang Wenge; Ho William C; Dicker David T; MacKinnon Colin; Winkler Jeffrey D; Marmorstein Ronen; El-Deiry Wafik S
Acridine derivatives activate p53 and induce tumor cell death through Bax.
Cancer biology & therapy 2005;4(8):893-8.
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2005: Liu Jue Judy; Wang Wenge; Dicker David T; El-Deiry Wafik S
Bioluminescent imaging of TRAIL-induced apoptosis through detection of caspase activation following cleavage of DEVD-aminoluciferin.
Cancer biology & therapy 2005;4(8):885-92.
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2005: El-Deiry Wafik S
Plagiarism is not acceptable in science or for cancer biology & therapy.
Cancer biology & therapy 2005;4(6):619-20.
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2005: El-Deiry Wafik S
Meeting report: The international conference on tumor progression and therapeutic resistance.
Cancer research 2005;65(11):4475-84.
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2005: Grimberg Adda; Coleman Carrie M; Burns Timothy F; Himelstein Bruce P; Koch Cameron J; Cohen Pinchas; El-Deiry Wafik S
p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia.
The Journal of clinical endocrinology and metabolism 2005;90(6):3568-74.
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2005: Dash Bipin C; El-Deiry Wafik S
Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity.
Molecular and cellular biology 2005;25(8):3364-87.
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2005: Finnberg Niklas; Gruber Joshua J; Fei Peiwen; Rudolph Dorothea; Bric Anka; Kim Seok-Hyun; Burns Timothy F; Ajuha Hope; Page Robert; Wu Gen Sheng; Chen Youhai; McKenna W Gillies; Bernhard Eric; Lowe Scott; Mak Tak; El-Deiry Wafik S
DR5 knockout mice are compromised in radiation-induced apoptosis.
Molecular and cellular biology 2005;25(5):2000-13.
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2005: Jin Zhaoyu; El-Deiry Wafik S
Overview of cell death signaling pathways.
Cancer biology & therapy 2005;4(2):139-63.
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2004: Lin Shih-Wen; Cook Michelle; Finnberg Niklas; Bernhard Eric; Baldwin Don; El-Deiry Wafik S
p53-dependent induction of serine proteases in irradiated mouse colon.
Cancer biology & therapy 2004;3(12):1290-7.
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2004: Fei Peiwen; Wang Wenge; Kim Seok-hyun; Wang Shulin; Burns Timothy F; Sax Joanna K; Buzzai Monica; Dicker David T; McKenna W Gillies; Bernhard Eric J; El-Deiry Wafik S
Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth.
Cancer cell 2004;6(6):597-609.
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2004: Tibbetts Michael D; Shiozaki Eric N; Gu Lichuan; McDonald E Robert; El-Deiry Wafik S; Shi Yigong
Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2.
Structure (London, England : 1993) 2004;12(12):2257-63.
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2004: Takaoka Munenori; Harada Hideki; Andl Claudia D; Oyama Kenji; Naomoto Yoshio; Dempsey Kelly L; Klein-Szanto Andres J; El-Deiry Wafik S; Grimberg Adda; Nakagawa Hiroshi
Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3.
Cancer research 2004;64(21):7711-23.
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2004: Ricci M Stacey; Jin Zhaoyu; Dews Michael; Yu Duonan; Thomas-Tikhonenko Andrei; Dicker David T; El-Deiry Wafik S
Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity.
Molecular and cellular biology 2004;24(19):8541-55.
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2004: Wang Shulin; El-Deiry Wafik S
Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil.
Cancer research 2004;64(18):6666-72.
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2004: Gruber Peter J; Li Zijun; Li Hui; Worrad Diane; Huang Bin; Abdullah Ibrahim; Wang Wenge; El-Deiry Wafik; Ferrari Victor A; Zhou Rong
In vivo imaging of MLC2v-luciferase, a cardiac-specific reporter gene expression in mice.
Academic radiology 2004;11(9):1022-8.
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2004: Wang Wenge; El-Deiry Wafik S
Targeting p53 by PTD-mediated transduction.
Trends in biotechnology 2004;22(9):431-4.
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2004: Shah Rishita; El-Deiry Wafik S
p53-Dependent activation of a molecular beacon in tumor cells following exposure to doxorubicin chemotherapy.
Cancer biology & therapy 2004;3(9):871-5.
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2004: Kim Seok-Hyun; Kim Kunhong; Kwagh Jae G; Dicker David T; Herlyn Meenhard; Rustgi Anil K; Chen Youhai; El-Deiry Wafik S
Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells.
The Journal of biological chemistry 2004;279(38):40044-52.
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2004: Jin Zhaoyu; McDonald E Robert; Dicker David T; El-Deiry Wafik S
Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis.
The Journal of biological chemistry 2004;279(34):35829-39.
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2004: Finnberg Niklas; El-Deiry Wafik S
Activating FOXO3a, NF-kappaB and p53 by targeting IKKs: an effective multi-faceted targeting of the tumor-cell phenotype?
Cancer biology & therapy 2004;3(7):614-6.
-
2004: Scata Kimberly A; El-Deiry Wafik S
Zebrafish: swimming towards a role for fanconi genes in DNA repair.
Cancer biology & therapy 2004;3(6):501-2.
-
2004: Thomas-Tikhonenko Andrei; Viard-Leveugle Isabelle; Dews Michael; Wehrli Philippe; Sevignani Cinzia; Yu Duonan; Ricci Stacey; el-Deiry Wafik; Aronow Bruce; Kaya Gürkan; Saurat Jean-Hilaire; French Lars E
Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo.
Cancer research 2004;64(9):3126-36.
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2004: Kim K; Nakagawa H; Fei P; Rustgi A K; El-Deiry W S
Targeting Bcl-xL in esophageal squamous cancer to sensitize to chemotherapy plus TRAIL-induced apoptosis while normal epithelial cells are protected by blockade of caspase 9.
Cell death and differentiation 2004;11(5):583-7.
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2004: McDonald E Robert; El-Deiry Wafik S
Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6170-5.
-
2004: Wang Wenge; El-Deiry Wafik S
Targeting FOXO kills two birds with one stone.
Chemistry & biology 2004;11(1):16-8.
-
2004: Wang Shulin; El-Deiry Wafik S
Cytochrome c: a crosslink between the mitochondria and the endoplasmic reticulum in calcium-dependent apoptosis.
Cancer biology & therapy 2004;3(1):44-6.
-
2004: Dash Bipin C; El-Deiry Wafik S
Cell cycle checkpoint control mechanisms that can be disrupted in cancer.
Methods in molecular biology (Clifton, N.J.) 2004;280():99-161.
-
2004: Wang Shulin; El-Deiry Wafik S
The p53 pathway: targets for the development of novel cancer therapeutics.
Cancer treatment and research 2004;119():175-87.
-
2003: Wang Shulin; El-Deiry Wafik S
Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15095-100.
-
2003: Rikhof Bart; Corn Paul G; El-Deiry Wafik S
Caspase 10 levels are increased following DNA damage in a p53-dependent manner.
Cancer biology & therapy 2003;2(6):707-12.
-
2003: Wang Shulin; El-Deiry Wafik S
TRAIL and apoptosis induction by TNF-family death receptors.
Oncogene 2003;22(53):8628-33.
-
2003: Das Sanjeev; El-Deiry Wafik S; Somasundaram Kumaravel
Efficient growth inhibition of HPV 16 E6-expressing cells by an adenovirus-expressing p53 homologue p73beta.
Oncogene 2003;22(52):8394-402.
-
2003: Corn Paul G; McDonald E Robert; Herman James G; El-Deiry Wafik S
Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein.
Nature genetics 2003;35(3):229-37.
-
2003: El-Deiry Wafik S
The role of p53 in chemosensitivity and radiosensitivity.
Oncogene 2003;22(47):7486-95.
-
2003: Choi Eugene A; Lei Hanqin; Maron David J; Wilson James M; Barsoum James; Fraker Douglas L; El-Deiry Wafik S; Spitz Francis R
Stat1-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand and the cell-surface death signaling pathway by interferon beta in human cancer cells.
Cancer research 2003;63(17):5299-307.
-
2003: Fei Peiwen; El-Deiry Wafik S
P53 and radiation responses.
Oncogene 2003;22(37):5774-83.
-
2003: Sax Joanna K; El-Deiry Wafik S
Identification and characterization of the cytoplasmic protein TRAF4 as a p53-regulated proapoptotic gene.
The Journal of biological chemistry 2003;278(38):36435-44.
-
2003: Burns Timothy F; Fei Peiwen; Scata Kimberly A; Dicker David T; El-Deiry Wafik S
Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells.
Molecular and cellular biology 2003;23(16):5556-71.
-
2003: Burns Timothy F; El-Deiry Wafik S
Microarray analysis of p53 target gene expression patterns in the spleen and thymus in response to ionizing radiation.
Cancer biology & therapy 2003;2(4):431-43.
-
2003: Sax Joanna K; Stoddard Alex; Murphy Maureen E; Chodosh Lewis; El-Deiry Wafik S
Microarray expression profiling of p53-dependent transcriptional changes in an immortalized mouse embryo fibroblast cell line.
Cancer biology & therapy 2003;2(4):416-30.
-
2003: Wang Wenge; Rastinejad Farzan; El-Deiry Wafik S
Restoring p53-dependent tumor suppression.
Cancer biology & therapy 2003;2(4 Suppl 1):S55-63.
-
2003: Benezra Miriam; Chevallier Nathalie; Morrison Debra J; MacLachlan Timothy K; El-Deiry Wafik S; Licht Jonathan D
BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit.
The Journal of biological chemistry 2003;278(29):26333-41.
-
2003: Campling Barbara G; El-Deiry Wafik S
Clinical implication of p53 mutation in lung cancer.
Molecular biotechnology 2003;24(2):141-56.
-
2003: Das Sanjeev; El-Deiry Wafik S; Somasundaram Kumaravel
Regulation of the p53 homolog p73 by adenoviral oncogene E1A.
The Journal of biological chemistry 2003;278(20):18313-20.
-
2003: Sax J K; El-Deiry W S
p53 downstream targets and chemosensitivity.
Cell death and differentiation 2003;10(4):413-7.
-
2003: Ozören Nesrin; El-Deiry Wafik S
Cell surface Death Receptor signaling in normal and cancer cells.
Seminars in cancer biology 2003;13(2):135-47.
-
2003: Gruss Claus J; Satyamoorthy Kapaettu; Berking Carola; Lininger John; Nesbit Mark; Schaider Helmut; Liu Zhao-June; Oka Masahiro; Hsu Mei-Yu; Shirakawa Takashi; Li Gang; Bogenrieder Thomas; Carmeliet Peter; El-Deiry Wafik S; Eck Stephen L; Rao Justi S; Baker Andrew H; Bennet Jean T; Crombleholme Timothy M; Velazquez Omaida; Karmacharya Jagajan; Margolis David J; Wilson James M; Detmar Michael; Skobe Mihaela; Robbins Paul D; Buck Clayton; Herlyn Meenhard
Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice.
The Journal of investigative dermatology 2003;120(4):683-92.
-
2003: Wang Wenge; El-Deiry Wafik S
Bioluminescent molecular imaging of endogenous and exogenous p53-mediated transcription in vitro and in vivo using an HCT116 human colon carcinoma xenograft model.
Cancer biology & therapy 2003;2(2):196-202.
-
2003: Wang Wenge; Takimoto Rishu; Rastinejad Farzan; El-Deiry Wafik S
Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.
Molecular and cellular biology 2003;23(6):2171-81.
-
2003: Corn Paul G; Summers Matthew K; Fogt Franz; Virmani Arvind K; Gazdar Adi F; Halazonetis Thanos D; El-Deiry Wafik S
Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.
Carcinogenesis 2003;24(1):47-51.
-
2003: Sax Joanna K; El-Deiry Wafik S
p53-induced gene expression analysis.
Methods in molecular biology (Clifton, N.J.) 2003;234():65-71.
-
2003: Dicker David T; El-Deiry Wafik S
Flow cytometric analysis of tumor suppressor gene-induced apoptosis.
Methods in molecular biology (Clifton, N.J.) 2003;223():271-82.
-
2003: MacLachlan Timothy K; El-Deiry Wafik S
Analysis of cyclin-dependent kinase activity.
Methods in molecular biology (Clifton, N.J.) 2003;223():217-20.
-
2003: Dicker David T; El-Deiry Wafik S
Flow cytometric analysis of cell cycle control by tumor suppressor genes.
Methods in molecular biology (Clifton, N.J.) 2003;223():211-5.
-
2003: McDonald E Robert; El-Deiry Wafik S
Yeast two-hybrid screening as a means of deciphering tumor suppressor pathways.
Methods in molecular biology (Clifton, N.J.) 2003;223():173-85.
-
2003: MacLachlan Timothy K; El-Deiry Wafik S
Identification of DNA-binding of tumor suppressor genes by chromatin immunoprecipitation.
Methods in molecular biology (Clifton, N.J.) 2003;223():129-33.
-
2003: Ricci M Stacey; El-Deiry Wafik S
DNA footprinting.
Methods in molecular biology (Clifton, N.J.) 2003;223():117-27.
-
2003: Burns Timothy F; el-Deiry Wafik S
Cell death signaling in maligancy.
Cancer treatment and research 2003;115():319-43.
-
2003: Campling Barbara G; el-Deiry Wafik S
Clinical implications of p53 mutations in lung cancer.
Methods in molecular medicine 2003;75():53-77.
-
2002: Fei Peiwen; Bernhard Eric J; El-Deiry Wafik S
Tissue-specific induction of p53 targets in vivo.
Cancer research 2002;62(24):7316-27.
-
2002: Ozören Nesrin; El-Deiry Wafik
Heat shock protects HCT116 and H460 cells from TRAIL-induced apoptosis.
Experimental cell research 2002;281(2):175-81.
-
2002: Venkataramani Ravichandran N; MacLachlan Timothy K; Chai Xiaomei; El-Deiry Wafik S; Marmorstein Ronen
Structure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity.
The Journal of biological chemistry 2002;277(50):48827-33.
-
2002: Ozören Nesrin; El-Deiry Wafik S
Defining characteristics of Types I and II apoptotic cells in response to TRAIL.
Neoplasia (New York, N.Y.) 2002;4(6):551-7.
-
2002: Sax Joanna K; Fei Peiwen; Murphy Maureen E; Bernhard Eric; Korsmeyer Stanley J; El-Deiry Wafik S
BID regulation by p53 contributes to chemosensitivity.
Nature cell biology 2002;4(11):842-9.
-
2002: El-Deiry Wafik S
Transactivation of repair genes by BRCA1.
Cancer biology & therapy 2002;1(5):490-1.
-
2002: Grimberg Adda; Liu Bingrong; Bannerman Peter; El-Deiry Wafik S; Cohen Pinchas
IGFBP-3 mediates p53-induced apoptosis during serum starvation.
International journal of oncology 2002;21(2):327-35.
-
2002: El-Deiry Wafik S
Phenomenology and scientific progress.
Cancer biology & therapy 2002;1(4):436-7.
-
2002: MacLachlan Timothy K; El-Deiry Wafik S
Apoptotic threshold is lowered by p53 transactivation of caspase-6.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9492-7.
-
2002: MacLachlan Timothy K; Takimoto Rishu; El-Deiry Wafik S
BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets.
Molecular and cellular biology 2002;22(12):4280-92.
-
2002: He Qin; Lee Dong Ik; Rong Rong; Yu Myounghee; Luo Xiuquan; Klein Michael; El-Deiry Wafik S; Huang Ying; Hussain Arif; Sheikh M Saeed
Endoplasmic reticulum calcium pool depletion-induced apoptosis is coupled with activation of the death receptor 5 pathway.
Oncogene 2002;21(17):2623-33.
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2002: Takimoto Rishu; MacLachlan Timothy K; Dicker David T; Niitsu Yoshiro; Mori Toshio; el-Deiry Wafik S
BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation.
Cancer biology & therapy 2002;1(2):177-86.
-
2002: Campbell Allyson M; Campling Barbara G; Algazy Kenneth M; el-Deiry Wafik S
Clinical and molecular features of small cell lung cancer.
Cancer biology & therapy 2002;1(2):105-12.
-
2002: Sax Joanna K; Dash Bipin C; Hong Rui; Dicker David T; El-Deiry Wafik S
The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21 (WAF1/CIP1 expression).
Cell cycle (Georgetown, Tex.) 2002;1(1):90-6.
-
2002: Jin Zhaoyu; Dicker David T; El-Deiry Wafik S
Enhanced sensitivity of G1 arrested human cancer cells suggests a novel therapeutic strategy using a combination of simvastatin and TRAIL.
Cell cycle (Georgetown, Tex.) 2002;1(1):82-9.
-
2002: Takimoto Rishu; Wang Wenge; Dicker David T; Rastinejad Farzan; Lyssikatos Joseph; el-Deiry Wafik S
The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein.
Cancer biology & therapy 2002;1(1):47-55.
-
2002: Corn Paul G; El-Deiry Wafik S
Derangement of growth and differentiation control in oncogenesis.
BioEssays : news and reviews in molecular, cellular and developmental biology 2002;24(1):83-90.
-
2001: Wang T; Kobayashi T; Takimoto R; Denes A E; Snyder E L; el-Deiry W S; Brachmann R K
hADA3 is required for p53 activity.
The EMBO journal 2001;20(22):6404-13.
-
2001: El-Deiry W S
Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling.
Cell death and differentiation 2001;8(11):1066-75.
-
2001: Higuchi H; Bronk S F; Takikawa Y; Werneburg N; Takimoto R; El-Deiry W; Gores G J
The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis.
The Journal of biological chemistry 2001;276(42):38610-8.
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2001: Burns T F; El-Deiry W S
Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach.
The Journal of biological chemistry 2001;276(41):37879-86.
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2001: Qiao L; Studer E; Leach K; McKinstry R; Gupta S; Decker R; Kukreja R; Valerie K; Nagarkatti P; El Deiry W; Molkentin J; Schmidt-Ullrich R; Fisher P B; Grant S; Hylemon P B; Dent P
Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.
Molecular biology of the cell 2001;12(9):2629-45.
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2001: Suliman Y; Opitz O G; Avadhani A; Burns T C; El-Deiry W; Wong D T; Rustgi A K
p63 expression is associated with p53 loss in oral-esophageal epithelia of p53-deficient mice.
Cancer research 2001;61(17):6467-73.
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2001: Burns T F; Bernhard E J; El-Deiry W S
Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo.
Oncogene 2001;20(34):4601-12.
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2001: Liu Q; El-Deiry W S; Gazitt Y
Additive effect of Apo2L/TRAIL and Adeno-p53 in the induction of apoptosis in myeloma cell lines.
Experimental hematology 2001;29(8):962-70.
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2001: Fisher M J; Virmani A K; Wu L; Aplenc R; Harper J C; Powell S M; Rebbeck T R; Sidransky D; Gazdar A F; El-Deiry W S
Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(6):1688-97.
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2001: McDonald E R; Chui P C; Martelli P F; Dicker D T; El-Deiry W S
Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling.
The Journal of biological chemistry 2001;276(18):14939-45.
-
2001: McDonald E R; El-Deiry W S
Checkpoint genes in cancer.
Annals of medicine 2001;33(2):113-22.
-
2001: El-Deiry W S
Akt takes centre stage in cell-cycle deregulation.
Nature cell biology 2001;3(3):E71-3.
-
2001: Goldberg G S; Jin Z; Ichikawa H; Naito A; Ohki M; El-Deiry W S; Tsuda H
Global effects of anchorage on gene expression during mammary carcinoma cell growth reveal role of tumor necrosis factor-related apoptosis-inducing ligand in anoikis.
Cancer research 2001;61(4):1334-7.
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2001: Kim K; Takimoto R; Dicker D T; Chen Y; Gazitt Y; El-Deiry W S
Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines.
International journal of oncology 2001;18(2):241-7.
-
2001: Takimoto R; El-Deiry W S
DNA replication blockade impairs p53-transactivation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):781-3.
-
2001: Meng R D; El-Deiry W S
p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma.
Experimental cell research 2001;262(2):154-69.
-
2001: Göke R; Göke A; Göke B; El-Deiry W S; Chen Y
Pioglitazone inhibits growth of carcinoid cells and promotes TRAIL-induced apoptosis by induction of p21waf1/cip1.
Digestion 2001;64(2):75-80.
-
2000: Ricci M S; el-Deiry W S
Novel strategies for therapeutic design in molecular oncology using gene expression profiles.
Current opinion in molecular therapeutics 2000;2(6):682-90.
-
2000: MacLachlan T K; El-Deiry W S
Pointing (zinc) fingers at BRCA1 targets.
Nature medicine 2000;6(12):1318-9.
-
2000: Mitchell K O; Ricci M S; Miyashita T; Dicker D T; Jin Z; Reed J C; El-Deiry W S
Bax is a transcriptional target and mediator of c-myc-induced apoptosis.
Cancer research 2000;60(22):6318-25.
-
2000: Ozoren N; Kim K; Burns T F; Dicker D T; Moscioni A D; El-Deiry W S
The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand.
Cancer research 2000;60(22):6259-65.
-
2000: MacLachlan T K; Dash B C; Dicker D T; El-Deiry W S
Repression of BRCA1 through a feedback loop involving p53.
The Journal of biological chemistry 2000;275(41):31869-75.
-
2000: Satyamoorthy K; Chehab N H; Waterman M J; Lien M C; El-Deiry W S; Herlyn M; Halazonetis T D
Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(9):467-74.
-
2000: El-Deiry W
AACR - 91st meeting. Novel concepts and targets for therapeutic manipulation.
IDrugs : the investigational drugs journal 2000;3(7):717-8.
-
2000: Ozören N; Fisher M J; Kim K; Liu C X; Genin A; Shifman Y; Dicker D T; Spinner N B; Lisitsyn N A; El-Deiry W S
Homozygous deletion of the death receptor DR4 gene in a nasopharyngeal cancer cell line is associated with TRAIL resistance.
International journal of oncology 2000;16(5):917-25.
-
2000: McDonald E R; El-Deiry W S
Cell cycle control as a basis for cancer drug development (Review).
International journal of oncology 2000;16(5):871-86.
-
2000: Takimoto R; El-Deiry W S
Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site.
Oncogene 2000;19(14):1735-43.
-
2000: Xu S Q; El-Deiry W S
p21(WAF1/CIP1) inhibits initiator caspase cleavage by TRAIL death receptor DR4.
Biochemical and biophysical research communications 2000;269(1):179-90.
-
2000: Meng R D; McDonald E R; Sheikh M S; Fornace A J; El-Deiry W S
The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(2):130-44.
-
2000: Kim K; Fisher M J; Xu S Q; el-Deiry W S
Molecular determinants of response to TRAIL in killing of normal and cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(2):335-46.
-
2000: MacLachlan T K; Somasundaram K; Sgagias M; Shifman Y; Muschel R J; Cowan K H; El-Deiry W S
BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression.
The Journal of biological chemistry 2000;275(4):2777-85.
-
2000: Park J S; Boyer S; Mitchell K; Gilfor D; Birrer M; Darlington G; El Deiry W; Firestone G L; Munger K; Band V; Fisher P B; Dent P
Expression of human papilloma virus E7 protein causes apoptosis and inhibits DNA synthesis in primary hepatocytes via increased expression of p21(Cip-1/WAF1/MDA6).
The Journal of biological chemistry 2000;275(1):18-28.
-
2000: Wu G S; Kim K; el-Deiry W S
KILLER/DR5, a novel DNA-damage inducible death receptor gene, links the p53-tumor suppressor to caspase activation and apoptotic death.
Advances in experimental medicine and biology 2000;465():143-51.
-
1999: Somasundaram K; MacLachlan T K; Burns T F; Sgagias M; Cowan K H; Weber B L; el-Deiry W S
BRCA1 signals ARF-dependent stabilization and coactivation of p53.
Oncogene 1999;18(47):6605-14.
-
1999: Wu G S; Burns T F; McDonald E R; Meng R D; Kao G; Muschel R; Yen T; el-Deiry W S
Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest.
Oncogene 1999;18(47):6411-8.
-
1999: Song S; MacLachlan T K; Meng R D; El-Deiry W S
Comparative gene expression profiling in response to p53 in a human lung cancer cell line.
Biochemical and biophysical research communications 1999;264(3):891-5.
-
1999: Maclachlan T K; Meng R D; El-Deiry W S
"p53: Twenty Years On" in Trieste, Italy, May 20-22, 1999.
Journal of cellular physiology 1999;181(2):371-4.
-
1999: Burns T F; El-Deiry W S
The p53 pathway and apoptosis.
Journal of cellular physiology 1999;181(2):231-9.
-
1999: Prabhu N S; Somasundaram K; Tian H; Enders G H; Satyamoorthy K; Herlyn M; El-Deiry W S
The administration schedule of cyclin-dependent kinase inhibitor gene therapy and etoposide chemotherapy is a major determinant of cytotoxicity.
International journal of oncology 1999;15(2):209-16.
-
1999: Sheikh M S; Huang Y; Fernandez-Salas E A; El-Deiry W S; Friess H; Amundson S; Yin J; Meltzer S J; Holbrook N J; Fornace A J
The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract.
Oncogene 1999;18(28):4153-9.
-
1999: Sun S Y; Yue P; Wu G S; El-Deiry W S; Shroot B; Hong W K; Lotan R
Implication of p53 in growth arrest and apoptosis induced by the synthetic retinoid CD437 in human lung cancer cells.
Cancer research 1999;59(12):2829-33.
-
1999: Wu G S; Burns T F; Zhan Y; Alnemri E S; El-Deiry W S
Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor.
Cancer research 1999;59(12):2770-5.
-
1999: Yang W L; Zeng Y X; El-Deiry W S; Nason-Burchenal K; Dmitrovsky E; Chin K V
Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
Molecular cell biology research communications : MCBRC 1999;1(2):125-31.
-
1999: Mitra J; Dai C Y; Somasundaram K; El-Deiry W S; Satyamoorthy K; Herlyn M; Enders G H
Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a).
Molecular and cellular biology 1999;19(5):3916-28.
-
1999: Sun S Y; Yue P; Wu G S; El-Deiry W S; Shroot B; Hong W K; Lotan R
Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells.
Oncogene 1999;18(14):2357-65.
-
1999: Mitchell K O; El-Deiry W S
Overexpression of c-Myc inhibits p21WAF1/CIP1 expression and induces S-phase entry in 12-O-tetradecanoylphorbol-13-acetate (TPA)-sensitive human cancer cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(4):223-30.
-
1999: Meng R D; Phillips P; El-Deiry W S
p53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin.
International journal of oncology 1999;14(1):5-14.
-
1998: Ravi R; Mookerjee B; van Hensbergen Y; Bedi G C; Giordano A; El-Deiry W S; Fuchs E J; Bedi A
p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300.
Cancer research 1998;58(20):4531-6.
-
1998: Pai S I; Wu G S; Ozören N; Wu L; Jen J; Sidransky D; El-Deiry W S
Rare loss-of-function mutation of a death receptor gene in head and neck cancer.
Cancer research 1998;58(16):3513-8.
-
1998: Prabhu N S; Somasundaram K; Satyamoorthy K; Herlyn M; El-Deiry W S
p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells.
International journal of oncology 1998;13(1):5-9.
-
1998: Bennett W P; el-Deiry W S; Rush W L; Guinee D G; Freedman A N; Caporaso N E; Welsh J A; Jones R T; Borkowski A; Travis W D; Fleming M V; Trastek V; Pairolero P C; Tazelaar H D; Midthun D; Jett J R; Liotta L A; Harris C C
p21waf1/cip1 and transforming growth factor beta 1 protein expression correlate with survival in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(6):1499-506.
-
1998: Tong B; Grimes H L; Yang T Y; Bear S E; Qin Z; Du K; El-Deiry W S; Tsichlis P N
The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation.
Molecular and cellular biology 1998;18(5):2462-73.
-
1998: Wu G S; Saftig P; Peters C; El-Deiry W S
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.
Oncogene 1998;16(17):2177-83.
-
1998: Zhang H; Somasundaram K; Peng Y; Tian H; Zhang H; Bi D; Weber B L; El-Deiry W S
BRCA1 physically associates with p53 and stimulates its transcriptional activity.
Oncogene 1998;16(13):1713-21.
-
1998: Sheikh M S; Burns T F; Huang Y; Wu G S; Amundson S; Brooks K S; Fornace A J; el-Deiry W S
p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha.
Cancer research 1998;58(8):1593-8.
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1998: Yeh W C; Pompa J L; McCurrach M E; Shu H B; Elia A J; Shahinian A; Ng M; Wakeham A; Khoo W; Mitchell K; El-Deiry W S; Lowe S W; Goeddel D V; Mak T W
FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.
Science (New York, N.Y.) 1998;279(5358):1954-8.
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1998: Blagosklonny M V; El-Deiry W S
Acute overexpression of wt p53 facilitates anticancer drug-induced death of cancer and normal cells.
International journal of cancer. Journal international du cancer 1998;75(6):933-40.
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1998: Gee M S; Sarkisian C J; el-Deiry W S
Identification of a novel AP-2 consensus DNA binding site.
Biochemical and biophysical research communications 1998;243(1):307-16.
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1998: Meng R D; Shih H; Prabhu N S; George D L; el-Deiry W S
Bypass of abnormal MDM2 inhibition of p53-dependent growth suppression.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(1):251-9.
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1998: Meng R D; El-Deiry W S
Tumor suppressor gene therapy for cancer: from the bench to the clinic.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 1998;1(3):205-10.
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1998: el-Deiry W S
Regulation of p53 downstream genes.
Seminars in cancer biology 1998;8(5):345-57.
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1998: el-Deiry W S
p21/p53, cellular growth control and genomic integrity.
Current topics in microbiology and immunology 1998;227():121-37.
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1997: Wu G S; Burns T F; McDonald E R; Jiang W; Meng R; Krantz I D; Kao G; Gan D D; Zhou J Y; Muschel R; Hamilton S R; Spinner N B; Markowitz S; Wu G; el-Deiry W S
KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene.
Nature genetics 1997;17(2):141-3.
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1997: Somasundaram K; Zhang H; Zeng Y X; Houvras Y; Peng Y; Zhang H; Wu G S; Licht J D; Weber B L; El-Deiry W S
Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.
Nature 1997;389(6647):187-90.
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1997: Zeng Y X; Somasundaram K; Prabhu N S; Krishnadasan R; el-Deiry W S
Detection and analysis of living, growth-inhibited mammalian cells following transfection.
BioTechniques 1997;23(1):88, 90, 92, 94.
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1997: Somasundaram K; El-Deiry W S
Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region.
Oncogene 1997;14(9):1047-57.
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1997: Shick L; Carman J H; Choi J K; Somasundaram K; Burrell M; Hill D E; Zeng Y X; Wang Y; Wiman K G; Salhany K; Kadesch T R; Monroe J G; Donehower L A; el-Deiry W S
Decreased immunoglobulin deposition in tumors and increased immature B cells in p53-null mice.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(2):121-31.
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1997: el-Deiry W S
Role of oncogenes in resistance and killing by cancer therapeutic agents.
Current opinion in oncology 1997;9(1):79-87.
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1997: Blagosklonny M V; Prabhu N S; El-Deiry W S
Defects in p21WAF1/CIP1, Rb, and c-myc signaling in phorbol ester-resistant cancer cells.
Cancer research 1997;57(2):320-5.
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1997: Zeng Y X; Somasundaram K; el-Deiry W S
AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression.
Nature genetics 1997;15(1):78-82.
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1997: Blagosklonny M V; Giannakakou P; el-Deiry W S; Kingston D G; Higgs P I; Neckers L; Fojo T
Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death.
Cancer research 1997;57(1):130-5.
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1996: Dowell S P; McGoogan E; Picksley S M; el-Deiry W S; Vogelstein B; Hall P A
Expression of p21waf1/Cip1, MDM2 and p53 in vivo: analysis of cytological preparations.
Cytopathology : official journal of the British Society for Clinical Cytology 1996;7(5):340-51.
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1996: Blagosklonny M V; Wu G S; Omura S; el-Deiry W S
Proteasome-dependent regulation of p21WAF1/CIP1 expression.
Biochemical and biophysical research communications 1996;227(2):564-9.
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1996: Gartel A L; Serfas M S; Gartel M; Goufman E; Wu G S; el-Deiry W S; Tyner A L
p21 (WAF1/CIP1) expression is induced in newly nondividing cells in diverse epithelia and during differentiation of the Caco-2 intestinal cell line.
Experimental cell research 1996;227(2):171-81.
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1996: Prabhu N S; Blagosklonny M V; Zeng Y X; Wu G S; Waldman T; El-Deiry W S
Suppression of cancer cell growth by adenovirus expressing p21(WAF1/CIP1) deficient in PCNA interaction.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(7):1221-9.
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1996: Blagosklonny M V; el-Deiry W S
In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug.
International journal of cancer. Journal international du cancer 1996;67(3):386-92.
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1996: Velculescu V E; El-Deiry W S
Biological and clinical importance of the p53 tumor suppressor gene.
Clinical chemistry 1996;42(6 Pt 1):858-68.
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1996: McDonald E R; Wu G S; Waldman T; El-Deiry W S
Repair Defect in p21 WAF1/CIP1 -/- human cancer cells.
Cancer research 1996;56(10):2250-5.
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1996: Wu G S; El-Deiry W S
Apoptotic death of tumor cells correlates with chemosensitivity, independent of p53 or bcl-2.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(4):623-33.
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1996: Zeng Y X; el-Deiry W S
Regulation of p21WAF1/CIP1 expression by p53-independent pathways.
Oncogene 1996;12(7):1557-64.
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1996: Baas I O; Offerhaus J A; El-Deiry W S; Wu T C; Hutchins G M; Kasper E K; Baughman K L; Baumgartner W A; Chiou C J; Hayward G S; Hruban R H
The WAF1-mediated p53 growth-suppressor pathway is intact in the coronary arteries of heart transplant recipients.
Human pathology 1996;27(4):324-9.
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1995: Bedi A; Barber J P; Bedi G C; el-Deiry W S; Sidransky D; Vala M S; Akhtar A J; Hilton J; Jones R J
BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: a mechanism of resistance to multiple anticancer agents.
Blood 1995;86(3):1148-58.
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1995: el-Deiry W S; Tokino T; Waldman T; Oliner J D; Velculescu V E; Burrell M; Hill D E; Healy E; Rees J L; Hamilton S R
Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.
Cancer research 1995;55(13):2910-9.
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1995: Wales M M; Biel M A; el Deiry W; Nelkin B D; Issa J P; Cavenee W K; Kuerbitz S J; Baylin S B
p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3.
Nature medicine 1995;1(6):570-7.
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1995: da Costa L T; Liu B; el-Deiry W; Hamilton S R; Kinzler K W; Vogelstein B; Markowitz S; Willson J K; de la Chapelle A; Downey K M
Polymerase delta variants in RER colorectal tumours.
Nature genetics 1995;9(1):10-1.
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1994: Shiohara M; el-Deiry W S; Wada M; Nakamaki T; Takeuchi S; Yang R; Chen D L; Vogelstein B; Koeffler H P
Absence of WAF1 mutations in a variety of human malignancies.
Blood 1994;84(11):3781-4.
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1994: Fan S; el-Deiry W S; Bae I; Freeman J; Jondle D; Bhatia K; Fornace A J; Magrath I; Kohn K W; O'Connor P M
p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.
Cancer research 1994;54(22):5824-30.
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1994: Tokino T; Thiagalingam S; el-Deiry W S; Waldman T; Kinzler K W; Vogelstein B
p53 tagged sites from human genomic DNA.
Human molecular genetics 1994;3(9):1537-42.
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1994: Pietenpol J A; Tokino T; Thiagalingam S; el-Deiry W S; Kinzler K W; Vogelstein B
Sequence-specific transcriptional activation is essential for growth suppression by p53.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):1998-2002.
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1994: el-Deiry W S; Harper J W; O'Connor P M; Velculescu V E; Canman C E; Jackman J; Pietenpol J A; Burrell M; Hill D E; Wang Y
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
Cancer research 1994;54(5):1169-74.
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1993: el-Deiry W S; Tokino T; Velculescu V E; Levy D B; Parsons R; Trent J M; Lin D; Mercer W E; Kinzler K W; Vogelstein B
WAF1, a potential mediator of p53 tumor suppression.
Cell 1993;75(4):817-25.
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1992: Kastan M B; Zhan Q; el-Deiry W S; Carrier F; Jacks T; Walsh W V; Plunkett B S; Vogelstein B; Fornace A J
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.
Cell 1992;71(4):587-97.
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1992: Yen R W; Vertino P M; Nelkin B D; Yu J J; el-Deiry W; Cumaraswamy A; Lennon G G; Trask B J; Celano P; Baylin S B
Isolation and characterization of the cDNA encoding human DNA methyltransferase.
Nucleic acids research 1992;20(9):2287-91.
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1992: el-Deiry W S; Kern S E; Pietenpol J A; Kinzler K W; Vogelstein B
Definition of a consensus binding site for p53.
Nature genetics 1992;1(1):45-9.
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1991: el-Deiry W S; Nelkin B D; Celano P; Yen R W; Falco J P; Hamilton S R; Baylin S B
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3470-4.
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1988: el-Deiry W S; So A G; Downey K M
Mechanisms of error discrimination by Escherichia coli DNA polymerase I.
Biochemistry 1988;27(2):546-53.
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1984: El-Deiry W S; Downey K M; So A G
Molecular mechanisms of manganese mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(23):7378-82.
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1982: Cupo P; El-Deiry W S; Whitney P L; Awad W M
Stability of acetylated and superguanidinated chymotrypsinogens.
Archives of biochemistry and biophysics 1982;216(2):600-4.
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1980: Cupo P; El-Deiry W; Whitney P L; Awad W M
Stabilization of proteins by guanidination.
The Journal of biological chemistry 1980;255(22):10828-33.
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