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Esam El-Fakahany

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Helena Janíčková; Vladimír Rudajev; Heikki Tanila; Pavel Zimčík; Esam E El-Fakahany; Jan Jakubik; Vladimír Doležal
Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid β(1-42).
Jan Jakubik; Helena Janíčková; Alena Randáková; Esam E El-Fakahany; Vladimír Doležal
Subtype differences in pre-coupling of muscarinic acetylcholine receptors.
Marianne K O Grant; Meredith J Noetzel; Kayla C De Lorme; Jan Jakubik; Vladimír Doležal; Esam E El-Fakahany
Pharmacological evaluation of the long-term effects of xanomeline on the M(1) muscarinic acetylcholine receptor.

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All Publications

2013: Helena Janíčková; Vladimír Rudajev; Heikki Tanila; Pavel Zimčík; Esam E El-Fakahany; Jan Jakubik; Vladimír Doležal
Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid β(1-42).
Neuropharmacology 2013;67():272-83.
2011: Jan Jakubik; Helena Janíčková; Alena Randáková; Esam E El-Fakahany; Vladimír Doležal
Subtype differences in pre-coupling of muscarinic acetylcholine receptors.
PloS one 2011;6(11):e27732.
2010: Marianne K O Grant; Meredith J Noetzel; Kayla C De Lorme; Jan Jakubik; Vladimír Doležal; Esam E El-Fakahany
Pharmacological evaluation of the long-term effects of xanomeline on the M(1) muscarinic acetylcholine receptor.
PloS one 2010;5(12):e15722.
2009: Meredith J Noetzel; Marianne K O Grant; Esam E El-Fakahany
Immediate and delayed consequences of xanomeline wash-resistant binding at the M3 muscarinic receptor.
Neurochemical research 2009;34(6):1138-49.
2009: Pavel Michal; Vladimír Rudajev; Esam E El-Fakahany; Vladimír Dolezal
Membrane cholesterol content influences binding properties of muscarinic M2 receptors and differentially impacts activation of second messenger pathways.
European journal of pharmacology 2009;606(1-3):50-60.
2009: Jan Jakubik; Alena Randáková; Esam E El-Fakahany; Vladimír Dolezal
Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors.
BMC pharmacology 2009;9():15.
2009: Cabadak Hulya; Adolfo E Cuadra; Esam E El-Fakahany; Beki Kan
M2, M3, and M4 muscarinic receptors are expressed in the guinea pig gallbladder.
Journal of receptor and signal transduction research 2009;29(1):63-6.
2009: Meredith J Noetzel; Marianne K O Grant; Esam E El-Fakahany
Mechanisms of M3 muscarinic receptor regulation by wash-resistant xanomeline binding.
Pharmacology 2009;83(5):301-17.
2008: Brian E Kane; Marianne K O Grant; Esam E El-Fakahany; David M Ferguson
Synthesis and evaluation of xanomeline analogs--probing the wash-resistant phenomenon at the M1 muscarinic acetylcholine receptor.
Bioorganic & medicinal chemistry 2008;16(3):1376-92.
2007: Kayla C De Lorme; Marianne K O Grant; Meredith J Noetzel; Sonya B Polson; Esam E El-Fakahany
Long-term changes in the muscarinic M1 receptor induced by instantaneous formation of wash-resistant xanomeline-receptor complex.
The Journal of pharmacology and experimental therapeutics 2007;323(3):868-76.
2007: Eva Machová; Jan Jakubik; Esam E El-Fakahany; Vladimír Dolezal
Wash-resistantly bound xanomeline inhibits acetylcholine release by persistent activation of presynaptic M(2) and M(4) muscarinic receptors in rat brain.
The Journal of pharmacology and experimental therapeutics 2007;322(1):316-23.
2007: Pavel Michal; Esam E El-Fakahany; Vladimír Dolezal
Muscarinic M2 receptors directly activate Gq/11 and Gs G-proteins.
The Journal of pharmacology and experimental therapeutics 2007;320(2):607-14.
2006: Kayla C De Lorme; Krista L Sikorski; Marianne K O Grant; Esam E El-Fakahany
Long-term wash-resistant effects of brief interaction of xanomeline at the M1 muscarinic receptor.
Neuroscience letters 2006;410(1):11-4.
2006: Jan Jakubik; Esam E El-Fakahany; Vladimír Dolezal
Differences in kinetics of xanomeline binding and selectivity of activation of G proteins at M(1) and M(2) muscarinic acetylcholine receptors.
Molecular pharmacology 2006;70(2):656-66.
2005: Marianne K O Grant; Esam E El-Fakahany
Persistent binding and functional antagonism by xanomeline at the muscarinic M5 receptor.
The Journal of pharmacology and experimental therapeutics 2005;315(1):313-9.
2005: Adolfo E Cuadra; Esam E El-Fakahany
Mechanisms of M(1) muscarinic receptor-mediated up-regulation of neuronal nitric oxide synthase in N1E-115 neuroblastoma cells.
Brain research. Molecular brain research 2005;134(2):198-204.
2004: Marianne K O Grant; Esam E El-Fakahany
Therapeutic interventions targeting the nitric oxide system: current and potential uses in obstetrics, bone disease and erectile dysfunction.
Life sciences 2004;74(14):1701-21.
2004: Jan Jakubik; Stanislav Tucek; Esam E El-Fakahany
Role of receptor protein and membrane lipids in xanomeline wash-resistant binding to muscarinic M1 receptors.
The Journal of pharmacology and experimental therapeutics 2004;308(1):105-10.
2002: Marianne K O Grant; Adolfo E Cuadra; Esam E El-Fakahany
Endogenous expression of nNOS protein in several neuronal cell lines.
Life sciences 2002;71(7):813-7.
2002: David R Linden; Esam E El-Fakahany
Arachidonic acid inhibition of muscarinic receptor-mediated nitric oxide production occurs at the level of calcium mobilization in Chinese hamster ovary cells.
Neurochemical research 2002;27(6):441-9.
2002: Jan Jakubik; Stanislav Tucek; Esam E El-Fakahany
Allosteric modulation by persistent binding of xanomeline of the interaction of competitive ligands with the M1 muscarinic acetylcholine receptor.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1033-41.
2002: David R Linden; Esam E El-Fakahany
Microglial derived nitric oxide decreases serotonin content in rat basophilic leukemia (RBL-2H3) cells.
European journal of pharmacology 2002;436(1-2):53-6.
2001: Arthur Christopoulos; Marianne K O Grant; N Ayoubzadeh; O N Kim; Per Sauerberg; Lone Jeppesen; Esam E El-Fakahany
Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists.
The Journal of pharmacology and experimental therapeutics 2001;298(3):1260-8.
2001: H H Wu; D J Selski; Esam E El-Fakahany; Steven C McLoon
The role of nitric oxide in development of topographic precision in the retinotectal projection of chick.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(12):4318-25.
2000: D K Waid; M Chell; Esam E El-Fakahany
M(2) and M(4) muscarinic receptor subtypes couple to activation of endothelial nitric oxide synthase.
Pharmacology 2000;61(1):37-42.
2000: Jan Jakubik; Esam E El-Fakahany; Stanislav Tucek
Evidence for a tandem two-site model of ligand binding to muscarinic acetylcholine receptors.
The Journal of biological chemistry 2000;275(25):18836-44.
2000: S Hossein Fatemi; Adolfo E Cuadra; Esam E El-Fakahany; R W Sidwell; Paul Thuras
Prenatal viral infection causes alterations in nNOS expression in developing mouse brains.
Neuroreport 2000;11(7):1493-6.
2000: David R Linden; M J Chell; Esam E El-Fakahany; Virginia S Seybold
Neurokinin(3) receptors couple to the activation of neuronal nitric-oxide synthase in stably transfected Chinese hamster ovary cells.
The Journal of pharmacology and experimental therapeutics 2000;293(2):559-68.
2000: J L Carriere; Esam E El-Fakahany
Choline is a full agonist in inducing activation of neuronal nitric oxide synthase via the muscarinic M1 receptor.
Pharmacology 2000;60(2):82-9.
2000: Ahmet Akici; Atila Karaalp; Ece ISkender; Arthur Christopoulos; Esam E El-Fakahany; Sule Oktay
Further evidence for the heterogeneity of functional muscarinic receptors in guinea pig gallbladder.
European journal of pharmacology 2000;388(1):115-23.
2000: Arthur Christopoulos; Marianne K O Grant; Esam E El-Fakahany
Transducer abstraction: a novel approach to the detection of partial agonist efficacy in radioligand binding studies.
Journal of pharmacological and toxicological methods 2000;43(1):55-67.
1999: Ahmet Akici; Atila Karaalp; E Skender; Esam E El-Fakahany; Sule Oktay
Muscarinic M(2) receptors are not primarily involved in the contraction of guinea-pig gallbladder smooth muscle.
Pharmacological research : the official journal of the Italian Pharmacological Society 1999;40(5):443-9.
1999: Arthur Christopoulos; AM Parsons; Michael J Lew; Esam E El-Fakahany
The assessment of antagonist potency under conditions of transient response kinetics.
European journal of pharmacology 1999;382(3):217-27.
1999: Arthur Christopoulos; Esam E El-Fakahany
Qualitative and quantitative assessment of relative agonist efficacy.
Biochemical pharmacology 1999;58(5):735-48.
1999: Marianne K O Grant; Arthur Christopoulos; Esam E El-Fakahany
Regulation of acetylcholine binding by ATP at the muscarinic M(1) receptor in intact CHO cells.
Brain research 1999;839(1):94-9.
1999: Pavel Michal; M Lysíková; Esam E El-Fakahany; Stanislav Tucek
Clozapine interaction with the M2 and M4 subtypes of muscarinic receptors.
European journal of pharmacology 1999;376(1-2):119-25.
1999: Arthur Christopoulos; AM Parsons; Esam E El-Fakahany
Pharmacological analysis of the novel mode of interaction between xanomeline and the M1 muscarinic acetylcholine receptor.
The Journal of pharmacology and experimental therapeutics 1999;289(3):1220-8.
1999: Arthur Christopoulos; JL Sorman; Frederick Mitchelson; Esam E El-Fakahany
Characterization of the subtype selectivity of the allosteric modulator heptane-1,7-bis-(dimethyl-3'-phthalimidopropyl) ammonium bromide (C7/3-phth) at cloned muscarinic acetylcholine receptors.
Biochemical pharmacology 1999;57(2):171-9.
1999: Arthur Christopoulos; Esam E El-Fakahany
The generation of nitric oxide by G protein-coupled receptors.
Life sciences 1999;64(1):1-15.
1999: AM Parsons; JL Sorman; Esam E El-Fakahany
Regulation of M1 muscarinic receptor-mediated signaling in intact cells by exogenous, but not endogenously produced, nitric oxide.
Neurochemical research 1999;24(1):85-94.
1999: Alan F Ernst; H H Wu; Esam E El-Fakahany; Steven C McLoon
NMDA receptor-mediated refinement of a transient retinotectal projection during development requires nitric oxide.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(1):229-35.
1998: Sule Oktay; Cabadak Hulya; Ece ISkender; Mehmet Zafer Gören; E Calişkan; O Orun; Nuray Aslan; Atila Karaalp; A Tolun; Nefise B Ulusoy; Allan Levey; Esam E El-Fakahany; Beki Kan
Evidence for the presence of muscarinic M2 and M4 receptors in guinea-pig gallbladder smooth muscle.
Journal of autonomic pharmacology 1998;18(4):195-204.
1998: Adolfo E Cuadra; Esam E El-Fakahany
Up-regulation of the neuronal form of nitric oxide synthase in response to prolonged muscarinic M1 receptor stimulation.
Journal of neurochemistry 1998;71(2):571-9.
1998: DR Wotta; AM Parsons; J Hu; A W Grande; Esam E El-Fakahany
M1 muscarinic receptors stimulate rapid and prolonged phases of neuronal nitric oxide synthase activity: involvement of different calcium pools.
Journal of neurochemistry 1998;71(2):487-97.
1998: Stanislav Tucek; Jan Jakubik; Vladimír Dolezal; Esam E El-Fakahany
Positive effects of allosteric modulators on the binding properties and the function of muscarinic acetylcholine receptors.
Journal of physiology, Paris 1998;92(3-4):241-3.
1998: Arthur Christopoulos; T L Pierce; JL Sorman; Esam E El-Fakahany
On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor.
Molecular pharmacology 1998;53(6):1120-30.
1998: DR Wotta; Elizabeth V Wattenberg; R B Langason; Esam E El-Fakahany
M1, M3 and M5 muscarinic receptors stimulate mitogen-activated protein kinase.
Pharmacology 1998;56(4):175-86.
1997: Arthur Christopoulos; Esam E El-Fakahany
Novel persistent activation of muscarinic M1 receptors by xanomeline.
European journal of pharmacology 1997;334(1):R3-4.
1997: Adolfo E Cuadra; Esam E El-Fakahany
Enhancement of maximal activation of neuronal nitric oxide synthase at muscarinic M1 receptors following prolonged agonist treatment.
European journal of pharmacology 1997;334(1):107-10.
1997: S Z Wang; S Y Lee; S Z Zhu; DR Wotta; AM Parsons; Esam E El-Fakahany
Activation of neuronal nitric oxide synthase by M2 muscarinic receptors associated with a small increase in intracellular calcium.
Pharmacology 1997;55(1):10-7.
1997: Jan Jakubik; Lucie Bacáková; Esam E El-Fakahany; Stanislav Tucek
Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.
Molecular pharmacology 1997;52(1):172-9.
1996: S Z Wang; S Y Lee; S Z Zhu; Esam E El-Fakahany
Differential coupling of m1, m3, and m5 muscarinic receptors to activation of neuronal nitric oxide synthase.
Pharmacology 1996;53(5):271-80.
1996: Jan Jakubik; Lucie Bacáková; Vera Lisá; Esam E El-Fakahany; Stanislav Tucek
Activation of muscarinic acetylcholine receptors via their allosteric binding sites.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8705-9.
1996: J Hu; Esam E El-Fakahany
Intricate regulation of nitric oxide synthesis in neurons.
Cellular signalling 1996;8(3):185-9.
1996: S Z Wang; R Edmundson; S Z Zhu; Esam E El-Fakahany
Selective enhancement of antagonist ligand binding at muscarinic M2 receptors by heparin due to receptor uncoupling.
European journal of pharmacology 1996;296(1):113-8.
1996: S Y Lee; S Z Zhu; Esam E El-Fakahany
Role of two highly conserved tyrosine residues in the m1 muscarinic receptor second transmembrane domain in ligand binding and receptor function.
Receptors & signal transduction 1996;6(1):43-52.
1995: Jan Jakubik; Lucie Bacáková; Esam E El-Fakahany; Stanislav Tucek
Constitutive activity of the M1-M4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists.
FEBS letters 1995;377(2):275-9.
1995: L Hejnová; Stanislav Tucek; Esam E El-Fakahany
Positive and negative allosteric interactions on muscarinic receptors.
European journal of pharmacology 1995;291(3):427-30.
1995: S Z Zhu; S Y Lee; S Z Wang; Esam E El-Fakahany
Investigation of the role of an amino acid triplet repeat in differentiating drug-receptor interaction at m1 and m2 muscarinic receptors.
Pharmacology 1995;51(5):298-307.
1995: S Z Wang; S Z Zhu; Esam E El-Fakahany
Expression of endogenous muscarinic acetylcholine receptors in Chinese hamster ovary cells.
European journal of pharmacology 1995;291(2):R1-2.
1995: A M Parsons; Esam E El-Fakahany; Virginia S Seybold
Tachykinins alter inositol phosphate formation, but not cyclic AMP levels, in primary cultures of neonatal rat spinal neurons through activation of neurokinin receptors.
Neuroscience 1995;68(3):855-65.
1995: Jan Jakubik; Lucie Bacáková; Esam E El-Fakahany; Stanislav Tucek
Subtype selectivity of the positive allosteric action of alcuronium at cloned M1-M5 muscarinic acetylcholine receptors.
The Journal of pharmacology and experimental therapeutics 1995;274(3):1077-83.
1995: J Hu; Esam E El-Fakahany
Anomalous increase in nitric oxide synthase activity by certain nitric oxide-generating compounds in intact neuronal cells.
Journal of neurochemistry 1995;65(1):117-24.
1995: J Hu; S Z Wang; Serena Scapecchi; Fulvio Gualtieri; Esam E El-Fakahany
Cardioselective derivatives of 2,2-diphenyl-2-ethylthioacetate do not discriminate between m2 and m3 muscarinic receptors expressed in CHO cells.
Pharmacology 1995;50(5):273-85.
1995: J Hu; J Fridlund; Esam E El-Fakahany
Regulation of neuronal nitric oxide synthase by histone, protamine, and myelin basic protein.
Neurochemical research 1995;20(4):497-503.
1995: costantino iadecola; X Xu; F Zhang; Esam E El-Fakahany; M Elizabeth Ross
Marked induction of calcium-independent nitric oxide synthase activity after focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1995;15(1):52-9.
1994: J Hu; M I Mahmoud; Esam E El-Fakahany
Polyamines inhibit nitric oxide synthase in rat cerebellum.
Neuroscience letters 1994;175(1-2):41-5.
1994: costantino iadecola; X Xu; F Zhang; J Hu; Esam E El-Fakahany
Prolonged inhibition of brain nitric oxide synthase by short-term systemic administration of nitro-L-arginine methyl ester.
Neurochemical research 1994;19(4):501-5.
1994: S Z Zhu; S Z Wang; J Hu; Esam E El-Fakahany
An arginine residue conserved in most G protein-coupled receptors is essential for the function of the m1 muscarinic receptor.
Molecular pharmacology 1994;45(3):517-23.
1994: J Hu; J H Lee; Esam E El-Fakahany
Inhibition of neuronal nitric oxide synthase by antipsychotic drugs.
Psychopharmacology 1994;114(1):161-6.
1994: S Z Wang; S Z Zhu; Esam E El-Fakahany
Efficient coupling of m5 muscarinic acetylcholine receptors to activation of nitric oxide synthase.
The Journal of pharmacology and experimental therapeutics 1994;268(2):552-7.
1994: J Hu; Esam E El-Fakahany
An artifact associated with using trypan blue exclusion to measure effects of amyloid beta on neuron viability.
Life sciences 1994;55(13):1009-16.
1993: J Hu; Esam E El-Fakahany
Allosteric interaction of dynorphin and myelin basic protein with muscarinic receptors.
Pharmacology 1993;47(6):351-9.
1993: J S Kiefer-Day; E S Abdallah; Carlos Forray; N H Lee; O N Kim; Esam E El-Fakahany
Effects of tacrine on brain muscarinic-receptor-mediated second-messenger signals.
Pharmacology 1993;47(2):98-110.
1993: J Hu; Esam E El-Fakahany
Role of intercellular and intracellular communication by nitric oxide in coupling of muscarinic receptors to activation of guanylate cyclase in neuronal cells.
Journal of neurochemistry 1993;61(2):578-85.
1993: S Z Wang; Esam E El-Fakahany
Application of transfected cell lines in studies of functional receptor subtype selectivity of muscarinic agonists.
The Journal of pharmacology and experimental therapeutics 1993;266(1):237-43.
1993: J Hu; Esam E El-Fakahany
beta-Amyloid 25-35 activates nitric oxide synthase in a neuronal clone.
Neuroreport 1993;4(6):760-2.
1993: J Hu; Esam E El-Fakahany
The calmodulin antagonist calmidazolium stimulates release of nitric oxide in neuroblastoma N1E-115 cells.
Neuroreport 1993;4(2):198-200.
1992: S Z Wang; S Z Zhu; Deborah C Mash; Esam E El-Fakahany
Comparison of the concentration of messenger RNA encoding four muscarinic receptor subtypes in control and Alzheimer brains.
Brain research. Molecular brain research 1992;16(1-2):64-70.
1992: S Z Wang; S Z Zhu; James A Joseph; Esam E El-Fakahany
Comparison of the level of mRNA encoding m1 and m2 muscarinic receptors in brains of young and aged rats.
Neuroscience letters 1992;145(2):149-52.
1992: A S Mohamed; Carlos Forray; M H Aly; Esam E El-Fakahany
Lack of intrinsic activity and significant subtype selectivity of SR 95639A at muscarinic receptors.
European journal of pharmacology 1992;227(2):181-7.
1992: J Hu; S Z Wang; Carlos Forray; Esam E El-Fakahany
Complex allosteric modulation of cardiac muscarinic receptors by protamine: potential model for putative endogenous ligands.
Molecular pharmacology 1992;42(2):311-21.
1992: N H Lee; J Hu; Esam E El-Fakahany
Modulation by certain conserved aspartate residues of the allosteric interaction of gallamine at the m1 muscarinic receptor.
The Journal of pharmacology and experimental therapeutics 1992;262(1):312-6.
1992: J S Kiefer-Day; Esam E El-Fakahany
Muscarinic receptor function and acetylcholinesterase activity after chronic administration of tacrine to mice at therapeutic drug concentrations.
Pharmacology 1992;44(2):71-80.
1991: J S Kiefer-Day; H E Campbell; J Towles; Esam E El-Fakahany
Muscarinic subtype selectivity of tetrahydroaminoacridine: possible relationship to its capricious efficacy.
European journal of pharmacology 1991;203(3):421-3.
1991: J C Fernando; E A Abdallah; M Evinger; Carlos Forray; Esam E El-Fakahany
The presence of an M4 subtype muscarinic receptor in the bovine adrenal medulla revealed by mRNA and receptor binding analyses.
European journal of pharmacology 1991;207(4):297-303.
1991: N H Lee; Esam E El-Fakahany
Allosteric antagonists of the muscarinic acetylcholine receptor.
Biochemical pharmacology 1991;42(2):199-205.
1991: J Hu; S Z Wang; Esam E El-Fakahany
Effects of agonist efficacy on desensitization of phosphoinositide hydrolysis mediated by m1 and m3 muscarinic receptors expressed in Chinese hamster ovary cells.
The Journal of pharmacology and experimental therapeutics 1991;257(3):938-45.
1991: N H Lee; Esam E El-Fakahany
Allosteric interactions at the m1, m2 and m3 muscarinic receptor subtypes.
The Journal of pharmacology and experimental therapeutics 1991;256(2):468-79.
1991: Sovitj Pou; W S Pou; Gerald M. Rosen; Esam E El-Fakahany
N-hydroxylamine is not an intermediate in the conversion of L-arginine to an activator of soluble guanylate cyclase in neuroblastoma N1E-115 cells.
The Biochemical journal 1991;273 ( Pt 3)():547-52.
1991: S Z Zhu; S Z Wang; E A Abdallah; Esam E El-Fakahany
DFP-induced regulation of cardiac muscarinic receptor mRNA in vivo measured by DNA-excess solution hybridization.
Life sciences 1991;48(26):2579-84.
1991: E A Abdallah; Esam E El-Fakahany
Lack of desensitization of muscarinic receptor-mediated second messenger signals in rat brain upon acute and chronic inhibition of acetylcholinesterase.
Journal of biochemical toxicology 1991;6(4):261-8.
1990: S Z Wang; J R Hu; R M Long; W S Pou; Carlos Forray; Esam E El-Fakahany
Agonist-induced down-regulation of m1 muscarinic receptors and reduction of their mRNA level in a transfected cell line.
FEBS letters 1990;276(1-2):185-8.
1990: Henry J Silverman; N H Lee; Esam E El-Fakahany
Effects of canine endotoxin shock on lymphocytic beta-adrenergic receptors.
Circulatory shock 1990;32(4):293-306.
1990: J R Hu; Esam E El-Fakahany
Selectivity of McN-A-343 in stimulating phosphoinositide hydrolysis mediated by M1 muscarinic receptors.
Molecular pharmacology 1990;38(6):895-903.
1990: E A Abdallah; W S Pou; Esam E El-Fakahany
Aging does not alter muscarinic receptor-mediated inhibition of cyclic AMP formation in the striatum and hippocampus.
Brain research 1990;534(1-2):234-6.
1990: Y Meng; J Hu; Esam E El-Fakahany
p-Fluoro-hexahydro-sila-difenidol exhibits poor selectivity between M3 and M1 muscarinic receptors.
Membrane biochemistry 1990;9(4):293-300.
1990: C M Arroyo; Carlos Forray; Esam E El-Fakahany; Gerald M. Rosen
Receptor-mediated generation of an EDRF-like intermediate in a neuronal cell line detected by spin trapping techniques.
Biochemical and biophysical research communications 1990;170(3):1177-83.
1990: W S Pou; Sovitj Pou; Gerald M. Rosen; Esam E El-Fakahany
EDRF release is a common pathway in the activation of guanylate cyclase by receptor agonists and calcium ionophores.
European journal of pharmacology 1990;182(2):393-4.
1990: E A Abdallah; Carlos Forray; Esam E El-Fakahany
Relationship between the partial inhibition of muscarinic receptor-mediated phosphoinositide hydrolysis by phorbol esters and tetrodotoxin in rat cerebral cortex.
Brain research. Molecular brain research 1990;8(1):1-7.
1990: Carlos Forray; Esam E El-Fakahany
On the involvement of multiple muscarinic receptor subtypes in the activation of phosphoinositide metabolism in rat cerebral cortex.
Molecular pharmacology 1990;37(6):893-902.
1990: W Surichamorn; Carlos Forray; Esam E El-Fakahany
Role of intracellular Ca2+ mobilization in muscarinic and histamine receptor-mediated activation of guanylate cyclase in N1E-115 neuroblastoma cells: assessment of the arachidonic acid release hypothesis.
Molecular pharmacology 1990;37(6):860-9.
1990: Allison Fryer; Esam E El-Fakahany; David B Jacoby
Parainfluenza virus type 1 reduces the affinity of agonists for muscarinic receptors in guinea-pig lung and heart.
European journal of pharmacology 1990;181(1-2):51-8.
1990: N H Lee; Esam E El-Fakahany
The allosteric binding profile of himbacine: a comparison with other cardioselective muscarinic antagonists.
European journal of pharmacology 1990;179(1-2):225-9.
1990: W S Lai; Terry B Rogers; Esam E El-Fakahany
Protein kinase C is involved in desensitization of muscarinic receptors induced by phorbol esters but not by receptor agonists.
The Biochemical journal 1990;267(1):23-9.
1990: Allison Fryer; Esam E El-Fakahany
Identification of three muscarinic receptor subtypes in rat lung using binding studies with selective antagonists.
Life sciences 1990;47(7):611-8.
1990: W S Lai; Esam E El-Fakahany
Antagonism by the diacylglycerol kinase inhibitor R59 022 of muscarinic receptor-mediated cyclic GMP formation and binding of [3H]N-methylscopolamine.
Biochemical pharmacology 1990;39(1):221-2.
1990: Esam E El-Fakahany; C L Cioffi
Molecular mechanisms of regulation of neuronal muscarinic receptor sensitivity.
Membrane biochemistry 1990;9(1):9-27.
1989: N H Lee; Allison Fryer; Carlos Forray; Esam E El-Fakahany
Different mechanisms of antagonism by methoctramine of two neuronal muscarinic receptor-mediated second messenger responses.
The Journal of pharmacology and experimental therapeutics 1989;251(3):992-9.
1989: W Surichamorn; E A Abdallah; Esam E El-Fakahany
Aging does not alter brain muscarinic receptor-mediated phosphoinositide hydrolysis and its inhibition by phorbol esters, tetrodotoxin and receptor desensitization.
The Journal of pharmacology and experimental therapeutics 1989;251(2):543-9.
1989: N H Lee; Esam E El-Fakahany
Mixed competitive and allosteric antagonism by gallamine of muscarinic receptor-mediated second messenger responses in N1E-115 neuroblastoma cells.
Journal of neurochemistry 1989;53(4):1300-8.
1989: N H Lee; Carlos Forray; Esam E El-Fakahany
Methoctramine, a cardioselective muscarinic antagonist, stimulates phosphoinositide hydrolysis in rat cerebral cortex.
European journal of pharmacology 1989;167(2):295-8.
1989: Michael McKinney; D Anderson; Carlos Forray; Esam E El-Fakahany
Characterization of the striatal M2 muscarinic receptor mediating inhibition of cyclic AMP using selective antagonists: a comparison with the brainstem M2 receptor.
The Journal of pharmacology and experimental therapeutics 1989;250(2):565-72.
1989: W Surichamorn; C L Amrhein; Carlos Forray; Esam E El-Fakahany
Inhibition of cyclic AMP formation in N1E-115 neuroblastoma cells is mediated by a non-cardiac M2 muscarinic receptor subtype.
Brain research 1989;493(2):320-5.
1989: C L Cioffi; Esam E El-Fakahany
Differential sensitivity of phosphoinositide and cyclic GMP responses to short-term regulation by a muscarinic agonist in mouse neuroblastoma cells. Correlation with down-regulation of cell surface receptors.
Biochemical pharmacology 1989;38(11):1827-34.
1989: Allison Fryer; Esam E El-Fakahany
An endogenous factor induces heterogeneity of binding sites of selective muscarinic receptor antagonists in rat heart.
Membrane biochemistry 1989;8(3):127-32.
1988: W Surichamorn; O N Kim; N H Lee; W S Lai; Esam E El-Fakahany
Effects of aging on the interaction of quinuclidinyl benzilate, N-methylscopolamine, pirenzepine, and gallamine with brain muscarinic receptors.
Neurochemical research 1988;13(12):1183-91.
1988: Esam E El-Fakahany; W Surichamorn; C L Amrhein; S Stenstrom; C L Cioffi; E Richelson; M McKinney
Pseudo-noncompetitive antagonism of muscarinic receptor-mediated cyclic GMP formation and phosphoinositide hydrolysis by pirenzepine.
The Journal of pharmacology and experimental therapeutics 1988;247(3):934-40.
1988: Michael McKinney; N H Lee; D J Anderson; L Vella-Rountree; Esam E El-Fakahany
Non-selectivity of amitriptyline for subtypes of brain muscarinic receptors demonstrated in binding and functional assays.
European journal of pharmacology 1988;157(1):51-60.
1988: C L Cioffi; Esam E El-Fakahany
Lack of alterations in muscarinic receptor subtypes and phosphoinositide hydrolysis upon acute DFP treatment.
European journal of pharmacology 1988;156(1):35-45.
1988: N H Lee; Esam E El-Fakahany
Influence of ligand choice on the apparent binding profile of gallamine to cardiac muscarinic receptors. Identification of three main types of gallamine-muscarinic receptor interactions.
The Journal of pharmacology and experimental therapeutics 1988;246(3):829-38.
1988: A Mattia; K L Marquis; A P Leccese; Esam E El-Fakahany; Julian E. Moreton
Electroencephalographic, behavioral and receptor binding correlates of phencyclinoids in the rat.
The Journal of pharmacology and experimental therapeutics 1988;246(2):797-802.
1988: Esam E El-Fakahany; Bradley E Alger; W S Lai; T A Pitler; Paul F Worley; Jay M Baraban
Neuronal muscarinic responses: role of protein kinase C.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(10):2575-83.
1988: V Ramkumar; Esam E El-Fakahany
Prolonged morphine treatment increases rat brain dihydropyridine binding sites: possible involvement in development of morphine dependence.
European journal of pharmacology 1988;146(1):73-83.
1988: W S Lai; Esam E El-Fakahany
Regulation of [3H]phorbol-12,13-dibutyrate binding sites in mouse neuroblastoma cells: simultaneous down-regulation by phorbol esters and desensitization of their inhibition of muscarinic receptor function.
The Journal of pharmacology and experimental therapeutics 1988;244(1):41-50.
1987: W S Lai; Esam E El-Fakahany
Phorbol ester-induced inhibition of cyclic GMP formation mediated by muscarinic receptors in murine neuroblastoma cells.
The Journal of pharmacology and experimental therapeutics 1987;241(2):366-73.
1986: C L Cioffi; Esam E El-Fakahany
Decreased binding of the muscarinic antagonist [3H]N-methylscopolamine in mouse brain following acute treatment with an organophosphate.
European journal of pharmacology 1986;132(2-3):147-54.
1986: Esam E El-Fakahany; J H Lee
Agonist-induced muscarinic acetylcholine receptor down-regulation in intact rat brain cells.
European journal of pharmacology 1986;132(1):21-30.
1986: Esam E El-Fakahany; C L Cioffi; M M Abdellatif; M M Miller
Competitive interaction of pirenzepine with rat brain muscarinic acetylcholine receptors.
European journal of pharmacology 1986;131(2-3):237-47.
1986: Norman H Lee; Vickram Ramkumar; Esam E El-Fakahany
Charge but not chemical class explains the selective binding of [3H]N-methylscopolamine to a subpopulation of [3H]quinuclidinyl benzilate binding sites in rat cerebral cortex homogenates.
European journal of pharmacology 1986;130(1-2):153-5.
1986: W S Lai; Esam E El-Fakahany
A selective effect of protein kinase C activation on pirenzepine high-affinity muscarinic receptors in a neuronal clone.
European journal of pharmacology 1986;129(1-2):201-2.
1986: C L Cioffi; Esam E El-Fakahany
Short-term desensitization of muscarinic cholinergic receptors in mouse neuroblastoma cells: selective loss of agonist low-affinity and pirenzepine high-affinity binding sites.
The Journal of pharmacology and experimental therapeutics 1986;238(3):916-23.
1986: Esam E El-Fakahany; V Ramkumar; W S Lai
Multiple binding affinities of N-methylscopolamine to brain muscarinic acetylcholine receptors: differentiation from M1 and M2 receptor subtypes.
The Journal of pharmacology and experimental therapeutics 1986;238(2):554-63.
1986: W S Lai; Esam E El-Fakahany
Interaction of 4-aminopyridine with [3H]phencyclidine receptors in rat brain homogenates.
Neuroscience letters 1986;67(1):87-91.
1986: N F Rogers; Esam E El-Fakahany
Morphine-induced opioid receptor down-regulation detected in intact adult rat brain cells.
European journal of pharmacology 1986;124(3):221-30.
1986: A Mattia; Esam E El-Fakahany; Julian E. Moreton
Behavioral and receptor binding studies of phencyclidine (PCP) and lithium interaction in the rat.
Life sciences 1986;38(11):975-84.
1986: A Mattia; A P Leccese; K L Marquis; Esam E El-Fakahany; Julian E. Moreton
Electroencephalographic (EEG), psychopharmacological, and receptor-binding profiles of 'phencyclinoids'.
NIDA research monograph 1986;64():94-111.
1985: J H Lee; Esam E El-Fakahany
[3H]N-Methylscopolamine binding to muscarinic receptors in intact adult rat brain cell aggregates.
Biochemical pharmacology 1985;34(24):4299-303.
1985: J H Lee; Esam E El-Fakahany
Use of intact rat brain cells as a model to study regulation of muscarinic acetylcholine receptors.
Life sciences 1985;37(6):515-21.
1985: N F Rogers; Esam E El-Fakahany
Intact brain cells: a novel model system for studying opioid receptor binding.
Life sciences 1985;37(4):307-14.
1985: V Ramkumar; Esam E El-Fakahany
Changes in the affinity of [3H]nimodipine binding sites in the brain upon chlorpromazine treatment and subsequent withdrawal.
Research communications in chemical pathology and pharmacology 1985;48(3):463-6.
1985: J H Lee; Esam E El-Fakahany
Heterogeneity of binding of muscarinic receptor antagonists in rat brain homogenates.
The Journal of pharmacology and experimental therapeutics 1985;233(3):707-14.
1985: W S Lai; V Ramkumar; Esam E El-Fakahany
Possible allosteric interaction of 4-aminopyridine with rat brain muscarinic acetylcholine receptors.
Journal of neurochemistry 1985;44(6):1936-42.
1985: J H Lee; Esam E El-Fakahany
Anomalous binding of [3H]N-methylscopolamine to rat brain muscarinic receptors.
European journal of pharmacology 1985;110(2):263-6.
1985: P Feigenbaum; Esam E El-Fakahany
Regulation of muscarinic cholinergic receptor density in neuroblastoma cells by brief exposure to agonist: possible involvement in desensitization of receptor function.
The Journal of pharmacology and experimental therapeutics 1985;233(1):134-40.
1985: N Khazan; G A Young; Esam E El-Fakahany; OKSOON CHOI; D Calligaro
Sigma opioid receptors; SKF-10,047 update.
Neuropeptides 1985;5(4-6):339-40.
1984: V Ramkumar; Esam E El-Fakahany
Increase in [3H]nitrendipine binding sites in the brain in morphine-tolerant mice.
European journal of pharmacology 1984;102(2):371-2.
1984: Esam E El-Fakahany; Amira T Eldefrawi; D L Murphy; L G Aguayo; D J Triggle; Edson X Albuquerque; ME Eldefrawi
Interactions of phencyclidine with crayfish muscle membranes. Sensitivity to calcium channel antagonists and other drugs.
Molecular pharmacology 1984;25(3):369-78.
1984: Esam E El-Fakahany; D J Triggle; Amira T Eldefrawi; ME Eldefrawi
Distinction between high-affinity [3H]phencyclidine binding sites and muscarinic receptors in guinea-pig ileum muscle.
The Journal of pharmacology and experimental therapeutics 1984;229(2):447-54.
1984: P Feigenbaum; Esam E El-Fakahany
Short-term regulation of muscarinic acetylcholine receptor binding in cultured nerve cells.
Research communications in chemical pathology and pharmacology 1984;43(3):519-22.
1984: Esam E El-Fakahany; M Pfenning; E Richelson
Kinetic effects of terbium ions on muscarinic acetylcholine receptors of murine neuroblastoma cells.
Journal of neurochemistry 1984;42(3):863-9.
1983: Esam E El-Fakahany; J R Lopez; E Richelson
Lanthanum binding to murine neuroblastoma cells.
Journal of neurochemistry 1983;40(6):1687-91.
1983: Esam E El-Fakahany; E Richelson
Effect of some calcium antagonists on muscarinic receptor-mediated cyclic GMP formation.
Journal of neurochemistry 1983;40(3):705-10.
1983: Esam E El-Fakahany; E Richelson
Antagonism by antidepressants of muscarinic acetylcholine receptors of human brain.
British journal of pharmacology 1983;78(1):97-102.
1982: E Richelson; Esam E El-Fakahany
Changes in the sensitivity of receptors for neurotransmitters and the actions of some psychotherapeutic drugs.
Mayo Clinic proceedings. Mayo Clinic 1982;57(9):576-82.
1982: ME Eldefrawi; Esam E El-Fakahany; D L Murphy; Amira T Eldefrawi; D J Triggle
High affinity binding of phencyclidine (PCP) to crayfish muscle. Displacement by calcium antagonists.
Biochemical pharmacology 1982;31(15):2549-52.
1982: Esam E El-Fakahany; Amira T Eldefrawi; ME Eldefrawi
Nicotinic acetylcholine receptor desensitization studied by [3H]perhydrohistrionicotoxin binding.
The Journal of pharmacology and experimental therapeutics 1982;221(3):694-700.
1981: Esam E El-Fakahany; E Richelson
Phenoxybenzamine and dibenamine interactions with calcium channel effectors of the muscarinic receptor.
Molecular pharmacology 1981;20(3):519-25.
1981: E Richelson; Esam E El-Fakahany
The molecular basis of neurotransmission at the muscarinic receptor.
Biochemical pharmacology 1981;30(21):2887-91.
1981: Esam E El-Fakahany; E Richelson
Effects of lanthanides on muscarinic acetylcholine receptor function.
Molecular pharmacology 1981;19(2):282-90.
1980: Esam E El-Fakahany; E Richelson
Involvement of calcium channels in short-term desensitization of muscarinic receptor-mediated cyclic GMP formation in mouse neuroblastoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(11):6897-901.
1980: Esam E El-Fakahany; E Richelson
Regulation of muscarinic receptor-mediated cyclic GMP synthesis by cultured mouse neuroblastoma cells.
Journal of neurochemistry 1980;35(4):941-8.
1980: Esam E El-Fakahany; E Richelson
Temperature dependence of muscarinic acetylcholine receptor activation, desensitization, and resensitization.
Journal of neurochemistry 1980;34(5):1288-95.
1980: M Ismail; A Ghazal; Esam E El-Fakahany
Cardiovascular effects of venom from the scorpion Buthus occitanus, Amoreux.
Toxicon : official journal of the International Society on Toxinology 1980;18(3):327-37.