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Mohammed El Mezgueldi

Research Profile

Chemicals & Drugs

Living Beings

Genes & Molecular Sequences

Amino Acid Sequences

Phenomena

Anatomy

Smooth Muscle

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Publications

TOP 3
Mikkel Herholdt Jensen; William Lehman; Kathleen G Morgan; James Watt; Thomas E Angelini; Sarah Appel; Mohammed El Mezgueldi; Cynthia Gallant; Julie L Hodgkinson; Jeffrey R Moore
Effects of basic calponin on the flexural mechanics and stability of F-actin.
Mark Pfuhl; Sameeh Al-Sarayreh; Mohammed El Mezgueldi
The calponin regulatory region is intrinsically unstructured: novel insight into actin-calponin and calmodulin-calponin interfaces using NMR spectroscopy.
Saira Ansari; Mustapha Alahyan; Steven B Marston; Mohammed El Mezgueldi
Role of caldesmon in the Ca2+ regulation of smooth muscle thin filaments: evidence for a cooperative switching mechanism.

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All Publications

2012: Mikkel Herholdt Jensen; William Lehman; Kathleen G Morgan; James Watt; Thomas E Angelini; Sarah Appel; Mohammed El Mezgueldi; Cynthia Gallant; Julie L Hodgkinson; Jeffrey R Moore
Effects of basic calponin on the flexural mechanics and stability of F-actin.
Cytoskeleton (Hoboken, N.J.) 2012;69(1):49-58.
2011: Mark Pfuhl; Sameeh Al-Sarayreh; Mohammed El Mezgueldi
The calponin regulatory region is intrinsically unstructured: novel insight into actin-calponin and calmodulin-calponin interfaces using NMR spectroscopy.
Biophysical journal 2011;100(7):1718-28.
2008: Saira Ansari; Mustapha Alahyan; Steven B Marston; Mohammed El Mezgueldi
Role of caldesmon in the Ca2+ regulation of smooth muscle thin filaments: evidence for a cooperative switching mechanism.
The Journal of biological chemistry 2008;283(1):47-56.
2008: Steven B Marston; Mohammed El Mezgueldi
Role of tropomyosin in the regulation of contraction in smooth muscle.
Advances in experimental medicine and biology 2008;644():110-23.
2007: Mahmooda Mirza; Paul Robinson; Elena Kremneva; O'neal Copeland; Olga P Nikolaeva; Hugh Watkins; Dmitrii I Levitsky; Charles Redwood; Mohammed El Mezgueldi; Steven B Marston
The effect of mutations in alpha-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments.
The Journal of biological chemistry 2007;282(18):13487-97.
2006: Mustapha Alahyan; Martin R Webb; Steven B Marston; Mohammed El Mezgueldi
The mechanism of smooth muscle caldesmon-tropomyosin inhibition of the elementary steps of the actomyosin ATPase.
The Journal of biological chemistry 2006;281(28):19433-48.
2003: Saira Ansari; Mohammed El Mezgueldi; Steven B Marston
Cooperative inhibition of actin filaments in the absence of tropomyosin.
Journal of muscle research and cell motility 2003;24(8):513-20.
2002: Mohammed El Mezgueldi; Nanyun Tang; Steven S Rosenfeld; E Michael Ostap
The kinetic mechanism of Myo1e (human myosin-IC).
The Journal of biological chemistry 2002;277(24):21514-21.
2002: Valerie B Patchell; Alexander V Vorotnikov; Yuan Gao; Douglas G Low; James S Evans; Abdellatif Fattoum; Mohammed El Mezgueldi; Steven B Marston; Barry A Levine
Phosphorylation of the minimal inhibitory region at the C-terminus of caldesmon alters its structural and actin binding properties.
Biochimica et biophysica acta 2002;1596(1):121-30.
1999: Yuan Gao; Valerie B Patchell; PA Huber; O'neal Copeland; Mohammed El Mezgueldi; Abdellatif Fattoum; B Calas; PB Thorsted; Steven B Marston; Barry A Levine
The interface between caldesmon domain 4b and subdomain 1 of actin studied by nuclear magnetic resonance spectroscopy.
Biochemistry 1999;38(47):15459-69.
1998: Steven B Marston; D Burton; O'neal Copeland; I Fraser; Yuan Gao; JL Hodgkinson; P Huber; B Levine; Mohammed El Mezgueldi; G Notarianni
Structural interactions between actin, tropomyosin, caldesmon and calcium binding protein and the regulation of smooth muscle thin filaments.
Acta physiologica Scandinavica 1998;164(4):401-14.
1998: Mohammed El Mezgueldi; O'neal Copeland; ID Fraser; Steven B Marston; PA Huber
Characterization of the functional properties of smooth muscle caldesmon domain 4a: evidence for an independent inhibitory actin-tropomyosin binding domain.
The Biochemical journal 1998;332 ( Pt 2)():395-401.
1998: PA Huber; Yuan Gao; ID Fraser; O'neal Copeland; Mohammed El Mezgueldi; D A Slatter; N E Keane; Steven B Marston; Barry A Levine
Structure-activity studies of the regulatory interaction of the 10 kilodalton C-terminal fragment of caldesmon with actin and the effect of mutation of caldesmon residues 691-696.
Biochemistry 1998;37(8):2314-26.
1998: PA Huber; Barry A Levine; O'neal Copeland; Steven B Marston; Mohammed El Mezgueldi
Characterisation of the effects of mutation of the caldesmon sequence 691glu-trp-leu-thr-lys-thr696 to pro-gly-his-tyr-asn-asn on caldesmon-calmodulin interaction.
FEBS letters 1998;423(1):93-7.
1997: JL Hodgkinson; Mohammed El Mezgueldi; Roger Craig; P Vibert; Steven B Marston; William Lehman
3-D image reconstruction of reconstituted smooth muscle thin filaments containing calponin: visualization of interactions between F-actin and calponin.
Journal of molecular biology 1997;273(1):150-9.
1996: Mohammed El Mezgueldi; Steven B Marston
The effects of smooth muscle calponin on the strong and weak myosin binding sites of F-actin.
The Journal of biological chemistry 1996;271(45):28161-7.
1996: Mohammed El Mezgueldi
Calponin.
The international journal of biochemistry & cell biology 1996;28(11):1185-9.
1996: PA Huber; Mohammed El Mezgueldi; Zenon Grabarek; D A Slatter; Barry A Levine; Steven B Marston
Multiple-sited interaction of caldesmon with Ca(2+)-calmodulin.
The Biochemical journal 1996;316 ( Pt 2)():413-20.
1996: Mohammed El Mezgueldi; P Strasser; Abdellatif Fattoum; Mario Gimona
Expressing functional domains of mouse calponin: involvement of the region around alanine 145 in the actomyosin ATPase inhibitory activity of calponin.
Biochemistry 1996;35(12):3654-61.