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Alex Elbrecht

Research Profile

Chemicals & Drugs

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Amino Acid Sequences

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Publications

TOP 3
Guo Q Shi; James F Dropinski; Brian McKeever; Shihua Xu; Joseph W Becker; Joel P Berger; Karen L Macnaul; Alex Elbrecht; Gaochao Zhou; Thomas W Doebber; Peiran Wang; Yu-Sheng Chao; Michael J Forrest; James V Heck; David E Moller; A Brian Jones
Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.
Jeffrey Yuan; Bruce Bush; Alex Elbrecht; Yuan Liu; Theresa Zhang; Wenqing Zhao; Richard Blevins
Enhanced homology searching through genome reading frame predetermination.
Alan D Adams; Zao Hu; Derek von Langen; Adonis Dadiz; Alex Elbrecht; Karen L Macnaul; Joel P Berger; Gaochao Zhou; Thomas W Doebber; Roger Meurer; Michael J Forrest; David E Moller; A Brian Jones
O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.

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All Publications

2005: Guo Q Shi; James F Dropinski; Brian McKeever; Shihua Xu; Joseph W Becker; Joel P Berger; Karen L Macnaul; Alex Elbrecht; Gaochao Zhou; Thomas W Doebber; Peiran Wang; Yu-Sheng Chao; Michael J Forrest; James V Heck; David E Moller; A Brian Jones
Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.
Journal of medicinal chemistry 2005;48(13):4457-68.
2004: Jeffrey Yuan; Bruce Bush; Alex Elbrecht; Yuan Liu; Theresa Zhang; Wenqing Zhao; Richard Blevins
Enhanced homology searching through genome reading frame predetermination.
Bioinformatics (Oxford, England) 2004;20(9):1416-27.
2003: Alan D Adams; Zao Hu; Derek von Langen; Adonis Dadiz; Alex Elbrecht; Karen L Macnaul; Joel P Berger; Gaochao Zhou; Thomas W Doebber; Roger Meurer; Michael J Forrest; David E Moller; A Brian Jones
O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.
Bioorganic & medicinal chemistry letters 2003;13(19):3185-90.
2003: Joel P Berger; Ann Petro; Karen L Macnaul; Linda J Kelly; Bei B Zhang; Karen Richards; Alex Elbrecht; Bruce A Johnson; Gaochao Zhou; Thomas W Doebber; Chhabi Biswas; Mona Parikh; Neelam Sharma; Michael R Tanen; G Marie Thompson; John Ventre; Alan D Adams; Ralph T Mosley; Richard S Surwit; David E Moller
Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator.
Molecular endocrinology (Baltimore, Md.) 2003;17(4):662-76.
2002: John G Menke; Karen L Macnaul; Nancy S Hayes; Joanne Baffic; Yu-Sheng Chao; Alex Elbrecht; Linda J Kelly; My-Hanh Lam; Azriel Schmidt; Soumya Sahoo; Jianhua Wang; Samuel D Wright; Patrick Xin; Gaochao Zhou; David E Moller; Carl P Sparrow
A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a).
Endocrinology 2002;143(7):2548-58.
2002: David Gerhold; Franklin Liu; Guoqiang Jiang; Zhihua Li; Jian Xu; Meiqing Lu; Jeffrey R Sachs; Ansuman Bagchi; Arthur Fridman; Daniel J Holder; Thomas W Doebber; Joel P Berger; Alex Elbrecht; David E Moller; Bei B Zhang
Gene expression profile of adipocyte differentiation and its regulation by peroxisome proliferator-activated receptor-gamma agonists.
Endocrinology 2002;143(6):2106-18.
2001: J Berger; Michael Tanen; Alex Elbrecht; Anne Hermanowski-Vosatka; David E Moller; Samuel D Wright; Rolf Thieringer
Peroxisome proliferator-activated receptor-gamma ligands inhibit adipocyte 11beta -hydroxysteroid dehydrogenase type 1 expression and activity.
The Journal of biological chemistry 2001;276(16):12629-35.
2000: Anne Hermanowski-Vosatka; David Gerhold; Steven S Mundt; V A Loving; M Lu; Y Chen; Alex Elbrecht; M Wu; Thomas W Doebber; L Kelly; Denise P Milot; Qiu Guo; Pei-ran Wang; Marc C Ippolito; Yu-Sheng Chao; Samuel D Wright; Rolf Thieringer
PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver.
Biochemical and biophysical research communications 2000;279(2):330-6.
2000: J Berger; Hansa V Patel; J Woods; N S Hayes; S A Parent; Joseph A Clemas; Mark D Leibowitz; Alex Elbrecht; Richard A Rachubinski; John P Capone; David E Moller
A PPARgamma mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus.
Molecular and cellular endocrinology 2000;162(1-2):57-67.
1999: Alex Elbrecht; Y Chen; A Adams; J Berger; P Griffin; T Klatt; B Zhang; John G Menke; Gaochao Zhou; Roy G Smith; David E Moller
L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma. The role of Cys313 in ligand binding.
The Journal of biological chemistry 1999;274(12):7913-22.
1999: J Berger; Mark D Leibowitz; Thomas W Doebber; Alex Elbrecht; B Zhang; Gaochao Zhou; Chhabi Biswas; C A Cullinan; N S Hayes; Yueming Li; Michael Tanen; John Ventre; Margaret S Wu; G D Berger; Ralph T Mosley; R Marquis; C Santini; Soumya P Sahoo; Richard L Tolman; Roy G Smith; David E Moller
Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects.
The Journal of biological chemistry 1999;274(10):6718-25.
1998: Gaochao Zhou; R Cummings; Yueming Li; S Mitra; H A Wilkinson; Alex Elbrecht; Jeffrey Donald Hermes; J M Schaeffer; Roy G Smith; David E Moller
Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer.
Molecular endocrinology (Baltimore, Md.) 1998;12(10):1594-604.
1996: B Zhang; J Berger; Gaochao Zhou; Alex Elbrecht; S Biswas; S White-Carrington; Deborah Szalkowski; David E Moller
Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma.
The Journal of biological chemistry 1996;271(50):31771-4.
1996: Andrew D Howard; Scott Feighner; Doris F Cully; JP Arena; P A Liberator; Charles I Rosenblum; M Hamelin; Donna L Hreniuk; Oksana C Palyha; J Anderson; P S Paress; C Diaz; M Chou; K K Liu; KK McKee; Sheng-Shung Pong; L Y Chaung; Alex Elbrecht; M Dashkevicz; Robert P Heavens; M Rigby; D J Sirinathsinghji; D C Dean; D G Melillo; Arthur A Patchett; Ravi P Nargund; P R Griffin; J A DeMartino; S K Gupta; James M Schaeffer; Roy G Smith; Lex H T Van Der Ploeg
A receptor in pituitary and hypothalamus that functions in growth hormone release.
Science (New York, N.Y.) 1996;273(5277):974-7.
1996: Alex Elbrecht; Y Chen; C A Cullinan; N Hayes; M d Leibowitz; David E Moller; J Berger
Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2.
Biochemical and biophysical research communications 1996;224(2):431-7.