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Jack Elias

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Won-Kyung Cho; Jack A Elias; Frank J Giordano; Robert J Homer; Yan Huang; Min-Jong Kang; Chang-Min Lee; Patty J Lee; William C Sessa; Terence K Trow; Chun Geun Lee
IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension.
Yang Zhou; Jeiwook Chae; Won-Kyung Cho; Jack A Elias; Min-Jong Kang; Jonathan L Koff; Chang-Min Lee; Jae-Young Lee; Han-Oh Park; Pyeong-Oh Yoon; Chun Geun Lee
Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary fibrosis.
Chun Geun Lee; Chang-Min Lee; Xueyan Peng; John Varga; Yang Zhou; Carol Feghali-Bostwick; Mridu Gulati; Erica L Herzog; Sergio A Jimenez; Farida Ahangari; Jack A Elias
Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-β1 signaling.

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2013: Won-Kyung Cho; Jack A Elias; Frank J Giordano; Robert J Homer; Yan Huang; Min-Jong Kang; Chang-Min Lee; Patty J Lee; William C Sessa; Terence K Trow; Chun Geun Lee
IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology 2013;304(2):L112-24.
2012: Yang Zhou; Jeiwook Chae; Won-Kyung Cho; Jack A Elias; Min-Jong Kang; Jonathan L Koff; Chang-Min Lee; Jae-Young Lee; Han-Oh Park; Pyeong-Oh Yoon; Chun Geun Lee
Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary fibrosis.
The Journal of biological chemistry 2012;287(50):41991-2000.
2012: Chun Geun Lee; Chang-Min Lee; Xueyan Peng; John Varga; Yang Zhou; Carol Feghali-Bostwick; Mridu Gulati; Erica L Herzog; Sergio A Jimenez; Farida Ahangari; Jack A Elias
Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-β1 signaling.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(5):2635-44.
2012: Charles Dela Cruz; Richard Flavell; Alex Gornitzky; Chuan Hua He; Adam Jacoby; Chun Geun Lee; Wei Liu; Bing Ma; Jack A Elias
Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses.
Cell host & microbe 2012;12(1):34-46.
2012: Min-Jong Kang; Bo Hye Kim; Do-Hyun Kim; Chun Geun Lee; Chang-Min Lee; Won-Kyung Cho; Gina Choe; Je-Min Choi; Jack A Elias
IL-18 induces emphysema and airway and vascular remodeling via IFN-γ, IL-17A, and IL-13.
American journal of respiratory and critical care medicine 2012;185(11):1205-17.
2012: Chun Geun Lee; Bing Ma; Mario Sznol; Yang Zhou; Farida Ahangari; Charles Dela Cruz; Ruth Halaban; Jack A Elias
Chitinase-like proteins in lung injury, repair, and metastasis.
Proceedings of the American Thoracic Society 2012;9(2):57-61.
2012: Vineet Bhandari; Rayman Choo-Wing; Anantha Krishnan Harijith; Robert J Homer; Huanxing Sun; Mansoor Ali Syed; Jack A Elias
Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2.
American journal of respiratory cell and molecular biology 2012;46(5):668-76.
2011: Chun Geun Lee; Bing Ma; Seyedtaghi Takyar; Farida Ahangari; Charles Delacruz; Chuan Hua He; Jack A Elias
Studies of vascular endothelial growth factor in asthma and chronic obstructive pulmonary disease.
Proceedings of the American Thoracic Society 2011;8(6):512-5.
2011: Hiroshi Matsuura; Yang Zhou; Charles Dela Cruz; Won Kyoo Cho; Geoffrey L Chupp; Jack A Elias; Dominik Hartl; Robert J Homer; Min-Jong Kang; Barbara Koller; Chun Geun Lee
Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema.
American journal of respiratory cell and molecular biology 2011;44(6):777-86.
2011: Bing Ma; Charles Dela Cruz; Dominik Hartl; Min-Jong Kang; Shervin Takyar; Robert J Homer; Chun Geun Lee; Jack A Elias
RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism.
American journal of respiratory and critical care medicine 2011;183(10):1322-35.
2011: Xueyan Peng; Ronald Reilkoff; Thomas Russell; Susan K Mathai; Lynne Murray; Richard Bucala; Qingsheng Chen; Jack A Elias; Ye Gan; Mridu Gulati; Erica L Herzog
Local apoptosis promotes collagen production by monocyte-derived cells in transforming growth factor β1-induced lung fibrosis.
Fibrogenesis & tissue repair 2011;4(1):12.
2011: Chun Geun Lee; Carla A Da Silva; Charles Dela Cruz; Farida Ahangari; Bing Ma; Min-Jong Kang; Chuan-Hua He; Seyedtaghi Takyar; Jack A Elias
Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury.
Annual review of physiology 2011;73():479-501.
2010: Carla A Da Silva; Pierre Pochard; Chun Geun Lee; Jack A Elias
Chitin particles are multifaceted immune adjuvants.
American journal of respiratory and critical care medicine 2010;182(12):1482-91.
2010: Paulette L Wright; Jun Yu; Y P Peter Di; Robert J Homer; Geoffrey L Chupp; Jack A Elias; Lauren Cohn; William C Sessa
Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation.
The Journal of experimental medicine 2010;207(12):2595-607.
2010: Myung Hyun Sohn; Min-Jong Kang; Hiroshi Matsuura; Vineet Bhandari; ningyuan chen; Chun Geun Lee; Jack A Elias
The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury.
American journal of respiratory and critical care medicine 2010;182(7):918-28.
2010: Chun Geun Lee; Jack A Elias
Role of breast regression protein-39/YKL-40 in asthma and allergic responses.
Allergy, asthma & immunology research 2010;2(1):20-7.
2009: Svetlana Chapoval; Chun Geun Lee; Chuyan Tang; Achsah D Keegan; Lauren Cohn; Kim Bottomly; Jack A Elias
Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation.
Clinical immunology (Orlando, Fla.) 2009;132(3):371-84.
2009: Chun Geun Lee; Dominik Hartl; Gap Ryol Lee; Barbara Koller; Hiroshi Matsuura; Carla A Da Silva; Myung Hyun Sohn; Lauren Cohn; Robert J Homer; Alexander A Kozhich; Alison A Humbles; Jennifer Kearley; Anthony J Coyle; Geoffrey L Chupp; Jennifer L Reed; Richard A Flavell; Jack A Elias
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.
The Journal of experimental medicine 2009;206(5):1149-66.
2009: Dominik Hartl; Chuan Hua He; Babara Koller; Carla A Da Silva; Yasushi Kobayashi; Chun Geun Lee; Richard A Flavell; Jack A Elias
Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):5098-106.
2009: Jonathan M Siner; Vineet Bhandari; Kathryn M Engle; Jack A Elias; Mark D Siegel
Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis.
Shock (Augusta, Ga.) 2009;31(4):348-53.
2009: Carla A Da Silva; Cécile Chalouni; Adam Williams; Dominik Hartl; Chun G Lee; Jack A Elias
Chitin is a size-dependent regulator of macrophage TNF and IL-10 production.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(6):3573-82.
2009: Dominik Hartl; Chun G Lee; Carla A Da Silva; Geoffrey L Chupp; Jack A Elias
Novel biomarkers in asthma: chemokines and chitinase-like proteins.
Current opinion in allergy and clinical immunology 2009;9(1):60-6.
2008: Chun Geun Lee; Carla A Da Silva; Jae-Young Lee; Dominik Hartl; Jack A Elias
Chitin regulation of immune responses: an old molecule with new roles.
Current opinion in immunology 2008;20(6):684-9.
2008: Chun Geun Lee; Dominik Hartl; Hiroshi Matsuura; Felicity M Dunlop; Pierre D Scotney; Louis J Fabri; Andrew D Nash; ningyuan chen; Chu-Yan Tang; Qingsheng Chen; Robert J Homer; Manuel Baca; Jack A Elias
Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production.
American journal of respiratory cell and molecular biology 2008;39(6):739-46.
2008: Dominik Hartl; Chuan Hua He; Barbara Koller; Carla A Da Silva; Robert J Homer; Chun G Lee; Jack A Elias
Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells.
The Journal of biological chemistry 2008;283(48):33472-82.
2008: Vineet Bhandari; Rayman Choo-Wing; Chun Geun Lee; Kamran Yusuf; Jonathan H Nedrelow; Namasivayam Ambalavanan; Herbert Malkus; Robert J Homer; Jack A Elias
Developmental regulation of NO-mediated VEGF-induced effects in the lung.
American journal of respiratory cell and molecular biology 2008;39(4):420-30.
2008: Carla A Da Silva; Dominik Hartl; Wei Liu; Chun G Lee; Jack A Elias
TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(6):4279-86.
2008: Min Jong Kang; Chun Geun Lee; Jae-Young Lee; Charles Dela Cruz; Zhijian J Chen; Richard I Enelow; Jack A Elias
Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice.
The Journal of clinical investigation 2008;118(8):2771-84.
2008: Carole Ober; Zheng Tan; Ying Sun; Jennifer D Possick; Lin Pan; Raluca Nicolae; Sadie Radford; Rodney R Parry; Andrea Heinzmann; Klaus A Deichmann; Lucille A Lester; James E Gern; Robert F Lemanske; Dan L Nicolae; Jack A Elias; Geoffrey L Chupp
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
The New England journal of medicine 2008;358(16):1682-91.
2008: Masashi Yamasaki; Hye-Ryun Kang; Robert J Homer; Svetlana Chapoval; Soo Jung Cho; Byung Jae Lee; Jack A Elias; Chun Geun Lee
P21 regulates TGF-beta1-induced pulmonary responses via a TNF-alpha-signaling pathway.
American journal of respiratory cell and molecular biology 2008;38(3):346-53.
2007: Geoffrey L Chupp; Chun Geun Lee; Nizar N Jarjour; Yun Michael Shim; Carole T Holm; Susan He; James Dziura; Jennifer L Reed; Anthony J Coyle; Peter Kiener; Mark Cullen; Martine Grandsaigne; Marie-Christine Dombret; Michel Aubier; Marina Pretolani; Jack A Elias
A chitinase-like protein in the lung and circulation of patients with severe asthma.
The New England journal of medicine 2007;357(20):2016-27.
2007: Svetlana Chapoval; Amal Al-Garawi; Jose M Lora; Ian Strickland; Bing Ma; Patty J Lee; Robert J Homer; Sankar Ghosh; Anthony J Coyle; Jack A Elias
Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):7030-41.
2007: Rayman Choo-Wing; Jonathan H Nedrelow; Robert J Homer; Jack A Elias; Vineet Bhandari
Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia.
American journal of physiology. Lung cellular and molecular physiology 2007;293(1):L142-50.
2007: Hye-Ryun Kang; Chun Geun Lee; Robert J Homer; Jack A Elias
Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis.
The Journal of experimental medicine 2007;204(5):1083-93.
2007: Vineet Bhandari; Jack A Elias
The role of angiopoietin 2 in hyperoxia-induced acute lung injury.
Cell cycle (Georgetown, Tex.) 2007;6(9):1049-52.
2007: Jonathan M Siner; Ge Jiang; Zaza I Cohen; Peiying Shan; Xuchen Zhang; Chun Geun Lee; Jack A Elias; Patty J Lee
VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(7):1422-32.
2007: Vineet Bhandari; Rayman Choo-Wing; Robert J Homer; Jack A Elias
Increased hyperoxia-induced mortality and acute lung injury in IL-13 null mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4993-5000.
2007: Hye-Ryun Kang; Soo Jung Cho; Chun Geun Lee; Robert J Homer; Jack A Elias
Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12.
The Journal of biological chemistry 2007;282(10):7723-32.
2007: Min Jong Kang; Robert J Homer; Amy Gallo; Chun Geun Lee; Kristina Crothers; Soo Jung Cho; Carolyn L Rochester; Hilary Cain; Geoffrey L Chupp; Ho Joo Yoon; Jack A Elias
IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1948-59.
2006: Vineet Bhandari; Rayman Choo-Wing; Chun Geun Lee; Zhou Zhu; Jonathan H Nedrelow; Geoffrey L Chupp; Xucher Zhang; Michael A Matthay; Lorraine B Ware; Robert J Homer; Patty J Lee; Anke Geick; Antonin R de Fougerolles; Jack A Elias
Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death.
Nature medicine 2006;12(11):1286-93.
2006: Robert J Homer; Zhou Zhu; Lauren Cohn; Chun Gun Lee; Wendy I White; Suping Chen; Jack A Elias
Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation.
American journal of physiology. Lung cellular and molecular physiology 2006;291(3):L502-11.
2006: Min Jong Kang; Chun Geun Lee; Soo Jung Cho; Robert J Homer; Jack A Elias
IFN-gamma-dependent DNA injury and/or apoptosis are critical in cigarette smoke-induced murine emphysema.
Proceedings of the American Thoracic Society 2006;3(6):517-8.
2006: Jack A Elias; Min Jong Kang; Kristina Crothers; Kristina Crouthers; Robert J Homer; Chun Geun Lee
State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice.
Proceedings of the American Thoracic Society 2006;3(6):494-8.
2006: Chun Geun Lee; Soojung Cho; Robert J Homer; Jack A Elias
Genetic control of transforming growth factor-beta1-induced emphysema and fibrosis in the murine lung.
Proceedings of the American Thoracic Society 2006;3(6):476-477.
2006: Vineet Bhandari; Rayman Choo-Wing; Svetlana Chapoval; Chun Geun Lee; C Tang; Yoon-Keun Kim; Bing Ma; Peter Baluk; Michelle I Lin; Donald M McDonald; Robert J Homer; William C Sessa; Jack A Elias
Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):11021-6.
2006: Chun Geun Lee; Hye-Ryun Kang; Robert J Homer; Geoffrey L Chupp; Jack A Elias
Transgenic modeling of transforming growth factor-beta(1): role of apoptosis in fibrosis and alveolar remodeling.
Proceedings of the American Thoracic Society 2006;3(5):418-23.
2006: Vineet Bhandari; Jack A Elias
Cytokines in tolerance to hyperoxia-induced injury in the developing and adult lung.
Free radical biology & medicine 2006;41(1):4-18.
2006: Bing Ma; Michael R Blackburn; Chun Geun Lee; Robert J Homer; Wei Liu; Richard A Flavell; Lynn Boyden; Richard P Lifton; Chun-Xiao Sun; Hays W J Young; Jack A Elias
Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis.
The Journal of clinical investigation 2006;116(5):1274-83.
2006: Bing Ma; Wei Liu; Robert J Homer; Patty J Lee; Anthony J Coyle; Jose M Lora; Chun Geun Lee; Jack A Elias
Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4968-78.
2006: Soo Jung Cho; Min Jong Kang; Robert J Homer; Hye-Ryun Kang; Xuchen Zhang; Patty J Lee; Jack A Elias; Chun Geun Lee
Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling.
The Journal of biological chemistry 2006;281(12):8161-8.
2006: Janci L Chunn; Amir Mohsenin; Hays W J Young; Chun Geun Lee; Jack A Elias; Rodney E Kellems; Janci Chunn Lindsay
Partially adenosine deaminase-deficient mice develop pulmonary fibrosis in association with adenosine elevations.
American journal of physiology. Lung cellular and molecular physiology 2006;290(3):L579-87.
2006: Patty J Lee; Xuchen Zhang; Peiying Shan; Bing Ma; Chun Geun Lee; Robert J Homer; Zhou Zhu; Mercedes Rincon; Brooke T Mossman; Jack A Elias
ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo.
The Journal of clinical investigation 2006;116(1):163-73.
2005: Bing Ma; Min Jong Kang; Chun Geun Lee; Svetlana Chapoval; Wei Liu; Qingsheng Chen; Anthony J Coyle; Jose M Lora; Dominic Picarella; Robert J Homer; Jack A Elias
Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema.
The Journal of clinical investigation 2005;115(12):3460-72.
2005: Jack A Elias; Robert J Homer; Qutayba Hamid; Chun Geun Lee
Chitinases and chitinase-like proteins in T(H)2 inflammation and asthma.
The Journal of allergy and clinical immunology 2005;116(3):497-500.
2005: Tao Zheng; Morgan Rabach; ningyuan chen; Lesley A Rabach; Xiaoxia Hu; Jack A Elias; Zhou Zhu
Molecular cloning and functional characterization of mouse chitotriosidase.
Gene 2005;357(1):37-46.
2005: Tao Zheng; Min Jong Kang; Kristina Crothers; Zhou Zhu; Wei Liu; Chun Geun Lee; Lesley A Rabach; Harold A Chapman; Robert J Homer; David Aldous; George T De Sanctis; George Desanctis; Stephen Underwood; Michael Graupe; Richard A Flavell; John A Schmidt; Jack A Elias
Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):8106-15.
2005: Chuan Hua He; Aaron B Waxman; Chun Geun Lee; Holger W Link; Morgan E Rabach; Bing Ma; Qingsheng Chen; Zhou Zhu; Mei Zhong; Keiko Nakayama; Keiichi I Nakayama; Robert J Homer; Jack A Elias
Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury.
The Journal of clinical investigation 2005;115(4):1039-48.
2005: Qingsheng Chen; Lesley A Rabach; Paul Noble; Tao Zheng; Chun Geun Lee; Robert J Homer; Jack A Elias
IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):2305-13.
2005: Robert J Homer; Jack A Elias
Airway remodeling in asthma: therapeutic implications of mechanisms.
Physiology (Bethesda, Md.) 2005;20():28-35.
2004: Alfin Vicencio IV; Chun Geun Lee; Soo Jung Cho; Oliver Eickelberg; Ying Chuu; Gabriel G Haddad; Jack A Elias
Conditional overexpression of bioactive transforming growth factor-beta1 in neonatal mouse lung: a new model for bronchopulmonary dysplasia?
American journal of respiratory cell and molecular biology 2004;31(6):650-6.
2004: Chun Geun Lee; Holger W Link; Peter Baluk; Robert J Homer; Svetlana Chapoval; Vineet Bhandari; Min Jong Kang; Lauren Cohn; Yoon-Keun Kim; Donald M McDonald; Jack A Elias
Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.
Nature medicine 2004;10(10):1095-103.
2004: Chun Geun Lee; Soo Jung Cho; Min Jong Kang; Svetlana Chapoval; Patty J Lee; Paul W Noble; Teshome Yehualaeshet; Binfeng Lu; Richard A Flavell; Jeffrey Milbrandt; Robert J Homer; Jack A Elias
Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis.
The Journal of experimental medicine 2004;200(3):377-89.
2004: Zhou Zhu; Tao Zheng; Robert J Homer; Yoon-Keun Kim; ningyuan chen; Lauren Cohn; Qutayba Hamid; Jack A Elias
Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.
Science (New York, N.Y.) 2004;304(5677):1678-82.
2004: Bing Ma; Zhou Zhu; Robert J Homer; Craig Gerard; Robert M Strieter; Jack A Elias
The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1872-81.
2004: Lauren Cohn; Jack A Elias; Geoffrey L Chupp
Asthma: mechanisms of disease persistence and progression.
Annual review of immunology 2004;22():789-815.
2003: Aaron B Waxman; Keyvan Mahboubi; Roy Knickelbein; Lin L Mantell; Nicholas Manzo; Jordan S Pober; Jack A Elias
Interleukin-11 and interleukin-6 protect cultured human endothelial cells from H2O2-induced cell death.
American journal of respiratory cell and molecular biology 2003;29(4):513-22.
2003: Jingming Wang; Qingsheng Chen; Jonathan Corne; Zhou Zhu; Chun Geun Lee; Vineet Bhandari; Robert J Homer; Jack A Elias
Pulmonary expression of leukemia inhibitory factor induces B cell hyperplasia and confers protection in hyperoxia.
The Journal of biological chemistry 2003;278(33):31226-32.
2003: Janci Chunn Lindsay; Chun Geun Lee; Hays W J Young; Zhou Zhu; Janci L Chunn; Min Jong Kang; Suman K Banerjee; Jack A Elias
Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway.
The Journal of clinical investigation 2003;112(3):332-44.
2003: Tao Zheng; Zhou Zhu; Wei Liu; Chun Geun Lee; Qingsheng Chen; Robert J Homer; Jack A Elias
Cytokine regulation of IL-13Ralpha2 and IL-13Ralpha1 in vivo and in vitro.
The Journal of allergy and clinical immunology 2003;111(4):720-8.
2003: Jack A Elias; Chun Geun Lee; Tao Zheng; Yun Shim; Zhou Zhu
Interleukin-13 and leukotrienes: an intersection of pathogenetic schema.
American journal of respiratory cell and molecular biology 2003;28(4):401-4.
2003: Zhou Zhu; Goran Enhorning; Tao Zheng; Qingsheng Chen; ningyuan chen; Robert J Homer; Jack A Elias
Interleukin-13 induces surfactant function abnormality in the murine lung.
Chest 2003;123(3 Suppl):375S-6S.
2003: Jack A Elias; Tao Zheng; Chun Geun Lee; Robert J Homer; Qingsheng Chen; Bing Ma; Michael Blackburn; Zhou Zhu
Transgenic modeling of interleukin-13 in the lung.
Chest 2003;123(3 Suppl):339S-45S.
2003: Jack A Elias; Chun Geun Lee; Tao Zheng; Bing Ma; Robert J Homer; Zhou Zhu
New insights into the pathogenesis of asthma.
The Journal of clinical investigation 2003;111(3):291-7.
2002: Chun Geun Lee; Robert J Homer; Lauren Cohn; Holger W Link; Sungsoo Jung; Joseph E Craft; Barney S Graham; Teresa Johnson; Jack A Elias
Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways.
The Journal of biological chemistry 2002;277(38):35466-74.
2002: Sophie Lanone; Tao Zheng; Zhou Zhu; Wei Liu; Chun Geun Lee; Bing Ma; Qingsheng Chen; Robert J Homer; Jingming Wang; Lesley A Rabach; Morgan E Rabach; J Michael Shipley; Steven D Shapiro; Robert M Senior; Jack A Elias
Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling.
The Journal of clinical investigation 2002;110(4):463-74.
2002: Robert J Homer; Tao Zheng; Geoffrey L Chupp; Susan He; Zhou Zhu; Quingshen Chen; Bing Ma; R Duncan Hite; Laurice I Gobran; Seamus A Rooney; Jack A Elias
Pulmonary type II cell hypertrophy and pulmonary lipoproteinosis are features of chronic IL-13 exposure.
American journal of physiology. Lung cellular and molecular physiology 2002;283(1):L52-9.
2002: Zhou Zhu; Tao Zheng; Chun Geun Lee; Robert J Homer; Jack A Elias
Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling.
Seminars in cell & developmental biology 2002;13(2):121-8.
2002: Zhou Zhu; Bing Ma; Tao Zheng; Robert J Homer; Chun Geun Lee; Israel F Charo; Paul Noble; Jack A Elias
IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2953-62.
2001: Zhou Zhu; Chun Geun Lee; Tao Zheng; Geoffrey L Chupp; Jingming Wang; Robert J Homer; Paul W Noble; Qutayba Hamid; Jack A Elias
Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice.
American journal of respiratory and critical care medicine 2001;164(10 Pt 2):S67-70.
2001: Tao Zheng; Zhou Zhu; Jingming Wang; Robert J Homer; Jack A Elias
IL-11: insights in asthma from overexpression transgenic modeling.
The Journal of allergy and clinical immunology 2001;108(4):489-96.
2001: Chun Geun Lee; Robert J Homer; Zhou Zhu; Sophie Lanone; X Wang; V Koteliansky; J Michael Shipley; Philip J Gotwals; Paul Noble; Quingshen Chen; Robert M Senior; Jack A Elias
Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1).
The Journal of experimental medicine 2001;194(6):809-21.
2001: Zhou Zhu; Bing Ma; Robert J Homer; Tao Zheng; Jack A Elias
Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice.
The Journal of biological chemistry 2001;276(27):25222-9.
2001: J T Chapman; Leo E Otterbein; Jack A Elias; Augustine M K Choi
Carbon monoxide attenuates aeroallergen-induced inflammation in mice.
American journal of physiology. Lung cellular and molecular physiology 2001;281(1):L209-16.
2001: Keyvan Mahboubi; F Li; Janet Plescia; Nancy C Kirkiles-Smith; Mehdi Mesri; Y Du; J M Carroll; Jack A Elias; Dario C Altieri; Jordan S Pober
Interleukin-11 up-regulates survivin expression in endothelial cells through a signal transducer and activator of transcription-3 pathway.
Laboratory investigation; a journal of technical methods and pathology 2001;81(3):327-34.
2000: Z Wang; Tao Zheng; Zhou Zhu; Robert J Homer; Richard J Riese; Harold A Chapman; Steven D Shapiro; Jack A Elias
Interferon gamma induction of pulmonary emphysema in the adult murine lung.
The Journal of experimental medicine 2000;192(11):1587-600.
2000: Tao Zheng; Zhou Zhu; Z Wang; Robert J Homer; Bing Ma; Richard J Riese; Harold A Chapman; Steven D Shapiro; Jack A Elias
Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema.
The Journal of clinical investigation 2000;106(9):1081-93.
2000: Chun Geun Lee; Ho Joo Yoon; Zhou Zhu; Holger W Link; Z Wang; JM Gwaltney; M Landry; Jack A Elias
Respiratory syncytial virus stimulation of vascular endothelial cell growth Factor/Vascular permeability factor.
American journal of respiratory cell and molecular biology 2000;23(5):662-9.
2000: Jingming Wang; Robert J Homer; Qingsheng Chen; Jack A Elias
Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):4051-61.
2000: J Corne; Geoffrey L Chupp; Chun Geun Lee; Robert J Homer; Zhou Zhu; Quingshen Chen; Bing Ma; Y Du; F Roux; J McArdle; Aaron B Waxman; Jack A Elias
IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury.
The Journal of clinical investigation 2000;106(6):783-91.
2000: Jingming Wang; Robert J Homer; L Hong; Lauren Cohn; Chun Geun Lee; S Jung; Jack A Elias
IL-11 selectively inhibits aeroallergen-induced pulmonary eosinophilia and Th2 cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):2222-31.
2000: Robert J Homer; Jack A Elias
Consequences of long-term inflammation. Airway remodeling.
Clinics in chest medicine 2000;21(2):331-43, ix.
2000: N S Ward; Aaron B Waxman; Robert J Homer; Lin L Mantell; O Einarsson; Y Du; Jack A Elias
Interleukin-6-induced protection in hyperoxic acute lung injury.
American journal of respiratory cell and molecular biology 2000;22(5):535-42.
2000: Jack A Elias
Airway remodeling in asthma. Unanswered questions.
American journal of respiratory and critical care medicine 2000;161(3 Pt 2):S168-71.
1999: Jack A Elias; Zhou Zhu; Geoffrey L Chupp; Robert J Homer
Airway remodeling in asthma.
The Journal of clinical investigation 1999;104(8):1001-6.
1999: N S Ward; Aaron B Waxman; O Einarsson; Jack A Elias
Interleukin-6 protection in hyperoxic lung injury.
Chest 1999;116(1 Suppl):26S.
1999: Aaron B Waxman; O Einarsson; T Seres; Roy Knickelbein; Robert J Homer; JB Warshaw; R Johnston; Jack A Elias
Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.
Chest 1999;116(1 Suppl):8S-9S.
1999: Ho Joo Yoon; Zhou Zhu; JM Gwaltney; Jack A Elias
Rhinovirus regulation of IL-1 receptor antagonist in vivo and in vitro: a potential mechanism of symptom resolution.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7461-9.
1999: Zhou Zhu; Robert J Homer; Z Wang; Quingshen Chen; Gregory P Geba; Jingming Wang; Y Zhang; Jack A Elias
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.
The Journal of clinical investigation 1999;103(6):779-88.
1999: Jingming Wang; Zhou Zhu; R Nolfo; Jack A Elias
Dexamethasone regulation of lung epithelial cell and fibroblast interleukin-11 production.
The American journal of physiology 1999;276(1 Pt 1):L175-85.
1998: Aaron B Waxman; O Einarsson; T Seres; Roy Knickelbein; JB Warshaw; R Johnston; Robert J Homer; Jack A Elias
Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.
The Journal of clinical investigation 1998;101(9):1970-82.
1998: W Tang; L Yang; Y C Yang; SX Leng; Jack A Elias
Transforming growth factor-beta stimulates interleukin-11 transcription via complex activating protein-1-dependent pathways.
The Journal of biological chemistry 1998;273(10):5506-13.
1997: Prabir Ray; W Tang; Peili Wang; Robert J Homer; C Kuhn; Richard A Flavell; Jack A Elias
Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes.
The Journal of clinical investigation 1997;100(10):2501-11.
1997: Zhou Zhu; W Tang; JM Gwaltney; Y Wu; Jack A Elias
Rhinovirus stimulation of interleukin-8 in vivo and in vitro: role of NF-kappaB.
The American journal of physiology 1997;273(4 Pt 1):L814-24.
1997: Jack A Elias; Y Wu; Tao Zheng; R Panettieri
Cytokine- and virus-stimulated airway smooth muscle cells produce IL-11 and other IL-6-type cytokines.
The American journal of physiology 1997;273(3 Pt 1):L648-55.
1997: SX Leng; Jack A Elias
Interleukin-11 inhibits macrophage interleukin-12 production.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2161-8.
1997: SX Leng; Jack A Elias
Interleukin-11.
The international journal of biochemistry & cell biology 1997;29(8-9):1059-62.
1996: W Tang; Gregory P Geba; Tao Zheng; Prabir Ray; Robert J Homer; C Kuhn; Richard A Flavell; Jack A Elias
Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction.
The Journal of clinical investigation 1996;98(12):2845-53.
1996: Carrie A Redlich; X Gao; S Rockwell; M Kelley; Jack A Elias
IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(4):1705-10.
1996: C L Rochester; Steven J Ackerman; Tao Zheng; Jack A Elias
Eosinophil-fibroblast interactions. Granule major basic protein interacts with IL-1 and transforming growth factor-beta in the stimulation of lung fibroblast IL-6-type cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(11):4449-56.
1996: Jack A Elias; Gregory P Geba; W Tang; R Schilz; Tao Zheng; B DiCosmo; Richard A Flavell
Transgenic modeling of cytokines in the investigation of pulmonary disease.
Chest 1996;109(3 Suppl):69S-73S.
1996: O Einarsson; Gregory P Geba; Zhou Zhu; M Landry; Jack A Elias
Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness.
The Journal of clinical investigation 1996;97(4):915-24.
1996: Zhou Zhu; W Tang; Anuradha Ray; Y Wu; O Einarsson; Marie L Landry; J Gwaltney; Jack A Elias
Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation.
The Journal of clinical investigation 1996;97(2):421-30.
1995: O Einarsson; Gregory P Geba; Z Zhou; Marie L Landry; R A Panettieri; D Tristram; R Welliver; A Metinko; Jack A Elias
Interleukin-11 in respiratory inflammation.
Annals of the New York Academy of Sciences 1995;762():89-100; discussion 100-1.
1995: Prabir Ray; DH Zhang; Jack A Elias; Anuradha Ray
Cloning of a differentially expressed I kappa B-related protein.
The Journal of biological chemistry 1995;270(18):10680-5.
1995: O Einarsson; Gregory P Geba; J R Panuska; Zhou Zhu; M Landry; Jack A Elias
Asthma-associated viruses specifically induce lung stromal cells to produce interleukin-11, a mediator of airways hyperreactivity.
Chest 1995;107(3 Suppl):132S-133S.
1995: B DiCosmo; Gregory P Geba; D Picarella; Jack A Elias; J A Rankin; B Stripp; Jeffrey A Whitsett; Richard A Flavell
Expression of interleukin-6 by airway epithelial cells. Effects on airway inflammation and hyperreactivity in transgenic mice.
Chest 1995;107(3 Suppl):131S.
1995: C L Rochester; Steven J Ackerman; Tao Zheng; J A Rankin; Jack A Elias
Major basic protein regulation of lung fibroblast cytokine production. Role of cytokine synergy and charge.
Chest 1995;107(3 Suppl):117S-118S.
1995: Carrie A Redlich; H M Delisser; Jack A Elias
Retinoic acid inhibition of transforming growth factor-beta-induced collagen production by human lung fibroblasts.
American journal of respiratory cell and molecular biology 1995;12(3):287-95.
1995: Jack A Elias; W Tang; Mark C Horowitz
Cytokine and hormonal stimulation of human osteosarcoma interleukin-11 production.
Endocrinology 1995;136(2):489-98.
1994: Tao Zheng; M H Nathanson; Jack A Elias
Histamine augments cytokine-stimulated IL-11 production by human lung fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(10):4742-52.
1994: B F DiCosmo; Gregory P Geba; D Picarella; Jack A Elias; J A Rankin; B R Stripp; Jeffrey A Whitsett; Richard A Flavell
Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity.
The Journal of clinical investigation 1994;94(5):2028-35.
1994: Eliot M Rosen; A Joseph; L Jin; S Rockwell; Jack A Elias; J Knesel; J Wines; J McClellan; M J Kluger; Itzhak D Goldberg
Regulation of scatter factor production via a soluble inducing factor.
The Journal of cell biology 1994;127(1):225-34.
1994: Jack A Elias; Tao Zheng; O Einarsson; M Landry; T Trow; N Rebert; J Panuska
Epithelial interleukin-11. Regulation by cytokines, respiratory syncytial virus, and retinoic acid.
The Journal of biological chemistry 1994;269(35):22261-8.
1994: R J Zitnik; N L Whiting; Jack A Elias
Glucocorticoid inhibition of interleukin-1-induced interleukin-6 production by human lung fibroblasts: evidence for transcriptional and post-transcriptional regulatory mechanisms.
American journal of respiratory cell and molecular biology 1994;10(6):643-50.
1994: Jack A Elias; Tao Zheng; N L Whiting; A Marcovici; T K Trow
Cytokine-cytokine synergy and protein kinase C in the regulation of lung fibroblast leukemia inhibitory factor.
The American journal of physiology 1994;266(4 Pt 1):L426-35.
1994: Jack A Elias; Tao Zheng; N L Whiting; T K Trow; William W. Merrill; R Zitnik; Prabir Ray; E M Alderman
IL-1 and transforming growth factor-beta regulation of fibroblast-derived IL-11.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2421-9.
1994: R J Zitnik; Robert M Kotloff; Jamshid Latifpour; Tao Zheng; N L Whiting; J Schwalb; Jack A Elias
Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):1419-27.
1993: R J Zitnik; Tao Zheng; Jack A Elias
cAMP inhibition of interleukin-1-induced interleukin-6 production by human lung fibroblasts.
The American journal of physiology 1993;264(3 Pt 1):L253-60.
1993: Eliot M Rosen; R J Zitnik; Jack A Elias; M M Bhargava; J Wines; Itzhak D Goldberg
The interaction of HGF-SF with other cytokines in tumor invasion and angiogenesis.
EXS 1993;65():301-10.
1992: P M Sampson; C L Rochester; B Freundlich; Jack A Elias
Cytokine regulation of human lung fibroblast hyaluronan (hyaluronic acid) production. Evidence for cytokine-regulated hyaluronan (hyaluronic acid) degradation and human lung fibroblast-derived hyaluronidase.
The Journal of clinical investigation 1992;90(4):1492-503.
1992: Jack A Elias; R J Zitnik
Cytokine-cytokine interactions in the context of cytokine networking.
American journal of respiratory cell and molecular biology 1992;7(4):365-7.
1991: Jack A Elias; V Lentz; P J Cummings
Transforming growth factor-beta regulation of IL-6 production by unstimulated and IL-1-stimulated human fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(10):3437-43.
1991: Jack A Elias; Robert M Kotloff
Mononuclear cell-fibroblast interactions in the human lung.
Chest 1991;99(3 Suppl):73S-79S.
1990: Robert M Kotloff; J Little; Jack A Elias
Human alveolar macrophage and blood monocyte interleukin-6 production.
American journal of respiratory cell and molecular biology 1990;3(5):497-505.
1990: Jack A Elias; M M Reynolds
Interleukin-1 and tumor necrosis factor synergistically stimulate lung fibroblast interleukin-1 alpha production.
American journal of respiratory cell and molecular biology 1990;3(1):13-20.
1990: Jack A Elias; V Lentz
IL-1 and tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):161-6.
1990: Jack A Elias; B Freundlich; J A Kern; Joel Rosenbloom
Cytokine networks in the regulation of inflammation and fibrosis in the lung.
Chest 1990;97(6):1439-45.
1990: Jack A Elias; B Freundlich; S Adams; Joel Rosenbloom
Regulation of human lung fibroblast collagen production by recombinant interleukin-1, tumor necrosis factor, and interferon-gamma.
Annals of the New York Academy of Sciences 1990;580():233-44.
1989: Jack A Elias; M M Reynolds; Robert M Kotloff; J A Kern
Fibroblast interleukin 1 beta: synergistic stimulation by recombinant interleukin 1 and tumor necrosis factor and posttranscriptional regulation.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(16):6171-5.
1989: Steven M Albelda; Jack A Elias; E M Levine; J A Kern
Endotoxin stimulates platelet-derived growth factor production from cultured human pulmonary endothelial cells.
The American journal of physiology 1989;257(2 Pt 1):L65-70.
1989: Jack A Elias; G Trinchieri; James M Beck; P L Simon; P B Sehgal; L T May; J A Kern
A synergistic interaction of IL-6 and IL-1 mediates the thymocyte-stimulating activity produced by recombinant IL-1-stimulated fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(2):509-14.
1988: Jack A Elias; R C Krol; B Freundlich; P M Sampson
Regulation of human lung fibroblast glycosaminoglycan production by recombinant interferons, tumor necrosis factor, and lymphotoxin.
The Journal of clinical investigation 1988;81(2):325-33.