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Thomas Eling

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Xingya Wang; Seung Joon Baek; Thomas E Eling
The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer.
Sachie Shimizu; Takashi Watanabe; Hiroki Yoshioka; Mitsutoshi Kadowaki; Atsushi Kambe; H Karimi Kinyamu; Thomas E Eling
Proteasome inhibitor MG132 induces NAG-1/GDF15 expression through the p38 MAPK pathway in glioblastoma cells.
Xingya Wang; Minsub Shim; Rachelle J Bienstock; Kali Chrysovergis; Thomas E Eling
The H6D variant of NAG-1/GDF15 inhibits prostate xenograft growth in vivo.

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2013: Xingya Wang; Seung Joon Baek; Thomas E Eling
The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer.
Biochemical pharmacology 2013;85(5):597-606.
2013: Sachie Shimizu; Takashi Watanabe; Hiroki Yoshioka; Mitsutoshi Kadowaki; Atsushi Kambe; H Karimi Kinyamu; Thomas E Eling
Proteasome inhibitor MG132 induces NAG-1/GDF15 expression through the p38 MAPK pathway in glioblastoma cells.
Biochemical and biophysical research communications 2013;430(4):1277-82.
2012: Xingya Wang; Minsub Shim; Rachelle J Bienstock; Kali Chrysovergis; Thomas E Eling
The H6D variant of NAG-1/GDF15 inhibits prostate xenograft growth in vivo.
The Prostate 2012;72(6):677-89.
2011: Xingya Wang; Philip J Kingsley; Larry J Marnett; Thomas E Eling
The role of NAG-1/GDF15 in the inhibition of intestinal polyps in APC/Min mice by sulindac.
Cancer prevention research (Philadelphia, Pa.) 2011;4(1):150-60.
2010: Melissa S Ashwell; Ryan P Ceddia; Ralph L House; Joseph P Cassady; Eugene J Eisen; Thomas E Eling; Jennifer B Collins; Sherry F Grissom; Jack Odle
Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis.
The Journal of nutritional biochemistry 2010;21(9):848-55.
2009: Atsushi Kambe; Hiroki Yoshioka; Hideki Kamitani; Takashi Watanabe; Seung Joon Baek; Thomas E Eling
The cyclooxygenase inhibitor sulindac sulfide inhibits EP4 expression and suppresses the growth of glioblastoma cells.
Cancer prevention research (Philadelphia, Pa.) 2009;2(12):1088-99.
2009: Genzo Iguchi; Kali Chrysovergis; Seong-Ho Lee; Seung Joon Baek; Robert Langenbach; Thomas E Eling
A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2.
Cancer letters 2009;282(2):152-8.
2008: Hiroki Yoshioka; Hideki Kamitani; Takashi Watanabe; Thomas E Eling
Nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) expression is increased by the histone deacetylase inhibitor trichostatin A.
The Journal of biological chemistry 2008;283(48):33129-37.
2008: Atsushi Kambe; Genzo Iguchi; Yuseok Moon; Hideki Kamitani; Takashi Watanabe; Thomas E Eling
Regulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agents.
Biochimica et biophysica acta 2008;1783(6):1211-9.
2008: Minsub Shim; Thomas E Eling
Vitamin E succinate induces NAG-1 expression in a p38 kinase-dependent mechanism.
Molecular cancer therapeutics 2008;7(4):961-71.
2008: Yuseok Moon; Jeung-Il Kim; Hyun Yang; Thomas E Eling
Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways.
Life sciences 2008;82(11-12):591-9.
2008: Seijiro Taniura; Hideki Kamitani; Takashi Watanabe; Thomas E Eling
Induction of cyclooxygenase-2 expression by interleukin-1beta in human glioma cell line, U87MG.
Neurologia medico-chirurgica 2008;48(11):500-5; discussion 505.
2007: Craig R Lee; Leping Li; Harvey W Mohrenweiser; Robert M Petrovich; Douglas A Bell; Frank G Bottone; Molly E Cook; Thomas E Eling; Joseph M Krahn; Darryl C Zeldin
Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1).
Pharmacogenetics and genomics 2007;17(2):145-60.
2006: Thomas E Eling; Seung Joon Baek; Minsub Shim; Chang Ho Lee
NSAID activated gene (NAG-1), a modulator of tumorigenesis.
Journal of biochemistry and molecular biology 2006;39(6):649-55.
2006: James R Lambert; Julie A Kelly; Minsub Shim; William E Huffer; Steven K Nordeen; Seung Joon Baek; Thomas E Eling; M Scott Lucia
Prostate derived factor in human prostate cancer cells: gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth.
Journal of cellular physiology 2006;208(3):566-74.
2006: Jeanelle M Martinez; Tina Sali; Ryuji Okazaki; Colleen H Anna; Melinda G Hollingshead; Curtis Hose; Anne Monks; Nigel J Walker; Seung Joon Baek; Thomas E Eling
Drug-induced expression of nonsteroidal anti-inflammatory drug-activated gene/macrophage inhibitory cytokine-1/prostate-derived factor, a putative tumor suppressor, inhibits tumor growth.
The Journal of pharmacology and experimental therapeutics 2006;318(2):899-906.
2006: Ryuji Okazaki; Yuseok Moon; Toshiyuki Norimura; Thomas E Eling
Ionizing radiation enhances the expression of the nonsteroidal anti-inflammatory drug-activated gene (NAG1) by increasing the expression of TP53 in human colon cancer cells.
Radiation research 2006;165(2):125-30.
2005: Yuseok Moon; Wayne C Glasgow; Thomas E Eling
Curcumin suppresses interleukin 1beta-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways.
The Journal of pharmacology and experimental therapeutics 2005;315(2):788-95.
2005: Frank G Bottone; Yuseok Moon; Brenda Alston-Mills; Thomas E Eling
Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.
The Journal of pharmacology and experimental therapeutics 2005;315(2):668-77.
2005: Yuseok Moon; Frank G Bottone; Michael F McEntee; Thomas E Eling
Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1.
Molecular cancer therapeutics 2005;4(10):1551-8.
2005: Jong-Sik Kim; Seung Joon Baek; Frank G Bottone; Tina Sali; Thomas E Eling
Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells.
Molecular cancer research : MCR 2005;3(9):511-7.
2005: Minsub Shim; Thomas E Eling
Protein kinase C-dependent regulation of NAG-1/placental bone morphogenic protein/MIC-1 expression in LNCaP prostate carcinoma cells.
The Journal of biological chemistry 2005;280(19):18636-42.
2005: Ralph L House; Joseph P Cassady; Eugene J Eisen; Thomas E Eling; Jennifer B Collins; Sherry F Grissom; Jack Odle
Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice.
Physiological genomics 2005;21(3):351-61.
2005: Frank G Bottone; Yuseok Moon; Jong Sik Kim; Brenda Alston-Mills; Minako Ishibashi; Thomas E Eling
The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3).
Molecular cancer therapeutics 2005;4(5):693-703.
2005: Jong-Sik Kim; Seung Joon Baek; Tina Sali; Thomas E Eling
The conventional nonsteroidal anti-inflammatory drug sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1/MIC-1/GDF-15.
Molecular cancer therapeutics 2005;4(3):487-93.
2005: Minako Ishibashi; Frank G Bottone; Seijiro Taniura; Hideki Kamitani; Takashi Watanabe; Thomas E Eling
The cyclooxygenase inhibitor indomethacin modulates gene expression and represses the extracellular matrix protein laminin gamma1 in human glioblastoma cells.
Experimental cell research 2005;302(2):244-52.
2004: Jeanelle M Martinez; Seung Joon Baek; Donna M Mays; Patricia K Tithof; Thomas E Eling; Nigel J Walker
EGR1 is a novel target for AhR agonists in human lung epithelial cells.
Toxicological sciences : an official journal of the Society of Toxicology 2004;82(2):429-35.
2004: Anshu K Jain; Scott M Moore; Kiyoshi Yamaguchi; Thomas E Eling; Seung Joon Baek
Selective nonsteroidal anti-inflammatory drugs induce thymosin beta-4 and alter actin cytoskeletal organization in human colorectal cancer cells.
The Journal of pharmacology and experimental therapeutics 2004;311(3):885-91.
2004: Frank G Bottone; Jeanelle M Martinez; Brenda Alston-Mills; Thomas E Eling
Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells.
Carcinogenesis 2004;25(3):349-57.
2004: Seung Joon Baek; Jong-Sik Kim; Jennifer B Nixon; Richard P DiAugustine; Thomas E Eling
Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1.
The Journal of biological chemistry 2004;279(8):6883-92.
2004: TONGGUANG WANG; Liya Qin; Bin Liu; Yuxin Liu; Belinda Wilson; Thomas E Eling; Robert Langenbach; Seijiro Taniura; Jau-Shyong Hong
Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia.
Journal of neurochemistry 2004;88(4):939-47.
2004: Jennifer B Nixon; Kyung Su Kim; Patricia W Lamb; Frank G Bottone; Thomas E Eling
15-Lipoxygenase-1 has anti-tumorigenic effects in colorectal cancer.
Prostaglandins, leukotrienes, and essential fatty acids 2004;70(1):7-15.
2003: Chang-Ho Lee; Young-Sook Jang; Sun-Ju Her; Young-Mee Moon; Seung Joon Baek; Thomas E Eling
Nordihydroguaiaretic acid, an antioxidant, inhibits transforming growth factor-beta activity through the inhibition of Smad signaling pathway.
Experimental cell research 2003;289(2):335-41.
2003: Leigh C Wilson; Seung Joon Baek; Allison Call; Thomas E Eling
Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) is induced by genistein through the expression of p53 in colorectal cancer cells.
International journal of cancer. Journal international du cancer 2003;105(6):747-53.
2003: Frank G Bottone; Jeanelle M Martinez; Jennifer B Collins; Cynthia A Afshari; Thomas E Eling
Gene modulation by the cyclooxygenase inhibitor, sulindac sulfide, in human colorectal carcinoma cells: possible link to apoptosis.
The Journal of biological chemistry 2003;278(28):25790-801.
2003: Md-Ruhul Amin; Hideki Kamitani; Habiba Sultana; Seijiro Taniura; Azharul Islam; Atsuko Sho; Minako Ishibashi; Thomas E Eling; Takashi Watanabe
Aspirin and indomethacin exhibit antiproliferative effects and induce apoptosis in T98G human glioblastoma cells.
Neurological research 2003;25(4):370-6.
2003: Jennifer B Nixon; Hideki Kamitani; Seung Joon Baek; Thomas E Eling
Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells.
Prostaglandins, leukotrienes, and essential fatty acids 2003;68(5):323-30.
2003: Donna Newman; Morito Sakaue; Ja Seok Koo; Kyung-Su Kim; Seung Joon Baek; Thomas E Eling; Anton M Jetten
Differential regulation of nonsteroidal anti-inflammatory drug-activated gene in normal human tracheobronchial epithelial and lung carcinoma cells by retinoids.
Molecular pharmacology 2003;63(3):557-64.
2003: Seung Joon Baek; Leigh C Wilson; Linda C Hsi; Thomas E Eling
Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity.
The Journal of biological chemistry 2003;278(8):5845-53.
2002: Linda C Hsi; Leigh C Wilson; Thomas E Eling
Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma.
The Journal of biological chemistry 2002;277(43):40549-56.
2002: Uddhav Kelavkar; Wayne C Glasgow; Thomas E Eling
The effect of 15-lipoxygenase-1 expression on cancer cells.
Current urology reports 2002;3(3):207-14.
2002: Seung Joon Baek; Leigh C Wilson; Chang-Ho Lee; Thomas E Eling
Dual function of nonsteroidal anti-inflammatory drugs (NSAIDs): inhibition of cyclooxygenase and induction of NSAID-activated gene.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1126-31.
2002: Seijiro Taniura; Hideki Kamitani; Takashi Watanabe; Thomas E Eling
Transcriptional regulation of cyclooxygenase-1 by histone deacetylase inhibitors in normal human astrocyte cells.
The Journal of biological chemistry 2002;277(19):16823-30.
2002: Kyung-Su Kim; Seung Joon Baek; Gordon P Flake; Charles D Loftin; Benjamin F Calvo; Thomas E Eling
Expression and regulation of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) in human and mouse tissue.
Gastroenterology 2002;122(5):1388-98.
2002: Frank G Bottone; Seung Joon Baek; Jennifer B Nixon; Thomas E Eling
Diallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells.
The Journal of nutrition 2002;132(4):773-8.
2002: Hideki Kamitani; Seijiro Taniura; Kenji Watanabe; Makoto Sakamoto; Takashi Watanabe; Thomas E Eling
Histone acetylation may suppress human glioma cell proliferation when p21 WAF/Cip1 and gelsolin are induced.
Neuro-oncology 2002;4(2):95-101.
2002: Seung Joon Baek; Leigh C Wilson; Thomas E Eling
Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53.
Carcinogenesis 2002;23(3):425-34.
2002: Hiroo Kawajiri; Linda C Hsi; Hideki Kamitani; Hiroshi Ikawa; Mark Geller; Toni Ward; Thomas E Eling; Wayne C Glasgow
Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity.
Archives of biochemistry and biophysics 2002;398(1):51-60.
2002: Wayne C Glasgow; Rutai Hui; Hideto Kameda; Thomas E Eling
13(S)-HpODE modulates mitogenic signal transduction through enhancing the phosphorylation and association of EGF receptor with the tyrosine phosphatase SHP-2.
Advances in experimental medicine and biology 2002;507():463-7.
2002: Uddhav Kelavkar; Cynthia Cohen; Thomas E Eling; KAMAL BADR
15-lipoxygenase-1 overexpression in prostate adenocarcinoma.
Advances in experimental medicine and biology 2002;507():133-45.
2002: Linda C Hsi; Julie Angerman-Stewart; Thomas E Eling
Modulation of cyclooxygenase-2 expression by APC in HT-29 human colorectal carcinoma cells.
Advances in experimental medicine and biology 2002;507():127-31.
2001: Uddhav Kelavkar; Jennifer B Nixon; Cynthia Cohen; Dirck L Dillehay; Thomas E Eling; KAMAL BADR
Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis.
Carcinogenesis 2001;22(11):1765-73.
2001: E Fritsche; Seung Joon Baek; L M King; Darryl C Zeldin; Thomas E Eling; Douglas A Bell
Functional characterization of cyclooxygenase-2 polymorphisms.
The Journal of pharmacology and experimental therapeutics 2001;299(2):468-76.
2001: Hideto Kameda; John Risinger; BB Han; Seung Joon Baek; J Carl Barrett; T Abe; T Takeuchi; Wayne C Glasgow; Thomas E Eling
Expression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression.
Molecular and cellular biology 2001;21(20):6895-905.
2001: Linda C Hsi; L Wilson; J Nixon; Thomas E Eling
15-lipoxygenase-1 metabolites down-regulate peroxisome proliferator-activated receptor gamma via the MAPK signaling pathway.
The Journal of biological chemistry 2001;276(37):34545-52.
2001: Seung Joon Baek; J M Horowitz; Thomas E Eling
Molecular cloning and characterization of human nonsteroidal anti-inflammatory drug-activated gene promoter. Basal transcription is mediated by Sp1 and Sp3.
The Journal of biological chemistry 2001;276(36):33384-92.
2001: Hiroshi Ikawa; Hideto Kameda; Hideki Kamitani; Seung Joon Baek; Jennifer B Nixon; Linda C Hsi; Thomas E Eling
Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells.
Experimental cell research 2001;267(1):73-80.
2001: Hideto Kameda; John Risinger; BB Han; Seung Joon Baek; J Carl Barrett; Wayne C Glasgow; Thomas E Eling
Identification of epidermal growth factor receptor- Grb2-associated binder-1-SHP-2 complex formation and its functional loss during neoplastic cell progression.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2001;12(6):307-18.
2001: Linda C Hsi; Hideki Kamitani; Joseph Cornicelli; Thomas E Eling
Evaluation of the activity and localization of 15-lipoxygenase-1 after introduction into human colorectal carcinoma Caco-2 cells.
Prostaglandins, leukotrienes, and essential fatty acids 2001;64(4-5):217-25.
2001: Seung Joon Baek; Kyung-Su Kim; Jennifer B Nixon; Leigh C Wilson; Thomas E Eling
Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities.
Molecular pharmacology 2001;59(4):901-8.
2001: Hideki Kamitani; Seijiro Taniura; Hiroshi Ikawa; Takashi Watanabe; Uddhav Kelavkar; Thomas E Eling
Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma.
Carcinogenesis 2001;22(1):187-91.
2000: Uddhav Kelavkar; Cynthia Cohen; Hideki Kamitani; Thomas E Eling; KAMAL BADR
Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging.
Carcinogenesis 2000;21(10):1777-87.
2000: Linda C Hsi; Seung Joon Baek; Thomas E Eling
Lack of cyclooxygenase-2 activity in HT-29 human colorectal carcinoma cells.
Experimental cell research 2000;256(2):563-70.
2000: Hideki Kamitani; Hideto Kameda; Uddhav Kelavkar; Thomas E Eling
A GATA binding site is involved in the regulation of 15-lipoxygenase-1 expression in human colorectal carcinoma cell line, caco-2.
FEBS letters 2000;467(2-3):341-7.
1999: Linda C Hsi; Julie Angerman-Stewart; Thomas E Eling
Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level.
Carcinogenesis 1999;20(11):2045-9.
1999: H Matsuura; Morito Sakaue; K Subbaramaiah; Hideki Kamitani; Thomas E Eling; A J Dannenberg; T Tanabe; H Inoue; J Arata; Anton M Jetten
Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases.
The Journal of biological chemistry 1999;274(41):29138-48.
1999: Rutai Hui; Hideto Kameda; John Risinger; Julie Angerman-Stewart; B Han; J Carl Barrett; Thomas E Eling; Wayne C Glasgow
The linoleic acid metabolite, 13-HpODE augments the phosphorylation of EGF receptor and SHP-2 leading to their increased association.
Prostaglandins, leukotrienes, and essential fatty acids 1999;61(2):137-43.
1999: Hideki Kamitani; Hiroshi Ikawa; Linda C Hsi; Takashi Watanabe; Raymond DuBois; Thomas E Eling
Regulation of 12-lipoxygenase in rat intestinal epithelial cells during differentiation and apoptosis induced by sodium butyrate.
Archives of biochemistry and biophysics 1999;368(1):45-55.
1999: SP Jayawickreme; Thomas Gray; Paul Nettesheim; Thomas E Eling
Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells.
The American journal of physiology 1999;276(4 Pt 1):L596-603.
1999: Hiroshi Ikawa; Hideki Kamitani; Benjamin F Calvo; Julie F Foley; Thomas E Eling
Expression of 15-lipoxygenase-1 in human colorectal cancer.
Cancer research 1999;59(2):360-6.
1999: Hideki Kamitani; M Geller; Thomas E Eling
The possible involvement of 15-lipoxygenase/leukocyte type 12-lipoxygenase in colorectal carcinogenesis.
Advances in experimental medicine and biology 1999;469():593-8.
1999: Wayne C Glasgow; Rutai Hui; SP Jayawickreme; Julie Angerman-Stewart; BB Han; Thomas E Eling
13(S)-HpODE augments epidermal growth factor signal transduction by attenuating EGF receptor dephosphorylation.
Advances in experimental medicine and biology 1999;469():371-5.
1998: Hideki Kamitani; M Geller; Thomas E Eling
Expression of 15-lipoxygenase by human colorectal carcinoma Caco-2 cells during apoptosis and cell differentiation.
The Journal of biological chemistry 1998;273(34):21569-77.
1998: Elizabeth Mary Hill; Thomas E Eling; Paul Nettesheim
Differentiation dependency of eicosanoid enzyme expression in human tracheobronchial cells.
Toxicology letters 1998;96-97():239-44.
1998: Elizabeth Mary Hill; Thomas E Eling; Paul Nettesheim
Changes in expression of 15-lipoxygenase and prostaglandin-H synthase during differentiation of human tracheobronchial epithelial cells.
American journal of respiratory cell and molecular biology 1998;18(5):662-9.
1998: Douglas C Goodwin; Michael R Gunther; Linda C Hsi; Brenda C Crews; Thomas E Eling; Ronald P Mason; Lawrence J Marnett
Nitric oxide trapping of tyrosyl radicals generated during prostaglandin endoperoxide synthase turnover. Detection of the radical derivative of tyrosine 385.
The Journal of biological chemistry 1998;273(15):8903-9.
1998: Linda C Hsi; Thomas E Eling
Inhibition of EGF-dependent mitogenesis by prostaglandin E2 in Syrian hamster embryo fibroblasts.
Prostaglandins, leukotrienes, and essential fatty acids 1998;58(4):271-81.
1997: Wayne C Glasgow; Rutai Hui; Angela L Everhart; SP Jayawickreme; Julie Angerman-Stewart; BB Han; Thomas E Eling
The linoleic acid metabolite, (13S)-hydroperoxyoctadecadienoic acid, augments the epidermal growth factor receptor signaling pathway by attenuation of receptor dephosphorylation. Differential response in Syrian hamster embryo tumor suppressor phenotypes.
The Journal of biological chemistry 1997;272(31):19269-76.
1997: Michael R Gunther; Linda C Hsi; J F Curtis; J K Gierse; Lawrence J Marnett; Thomas E Eling; Ronald P Mason
Nitric oxide trapping of the tyrosyl radical of prostaglandin H synthase-2 leads to tyrosine iminoxyl radical and nitrotyrosine formation.
The Journal of biological chemistry 1997;272(27):17086-90.
1997: N Reddy; Angela L Everhart; Thomas E Eling; Wayne C Glasgow
Characterization of a 15-lipoxygenase in human breast carcinoma BT-20 cells: stimulation of 13-HODE formation by TGF alpha/EGF.
Biochemical and biophysical research communications 1997;231(1):111-6.
1997: Wayne C Glasgow; Thomas E Eling
Structural requirements for enhancement of EGF-dependent DNA synthesis by oxygenated metabolites of linoleic acid.
Advances in experimental medicine and biology 1997;400A():507-12.
1997: Thomas E Eling; Elizabeth Mary Hill; Wayne C Glasgow
Role of arachidonic acid and linoleic acid metabolism in epidermal growth factor initiated proliferation of Syrian hamster embryo fibroblasts.
Advances in experimental medicine and biology 1997;400A():495-500.
1997: J Kitzler; R Hardman; E Hill; N Reddy; RM Philpot; Thomas E Eling
Cloning and sequencing of prostaglandin H synthetase from rat tracheal epithelial cells: structural evidence that a TPA regulated mRNA codes for the rat ortholog of murine PHS-1.
Advances in experimental medicine and biology 1997;400A():65-70.
1997: Thomas E Eling; Angela L Everhart; Julie Angerman-Stewart; Rutai Hui; Wayne C Glasgow
Modulation of epidermal growth factor signal transduction by linoleic acid metabolites.
Advances in experimental medicine and biology 1997;407():319-22.
1996: J W Kitzler; Thomas E Eling
Cloning, sequencing and expression of a 5-lipoxygenase from Syrian hamster embryo fibroblasts.
Prostaglandins, leukotrienes, and essential fatty acids 1996;55(4):269-77.
1996: Charles D Loftin; Thomas E Eling
Prostaglandin synthase 2 expression in epidermal growth factor-dependent proliferation of mouse keratinocytes.
Archives of biochemistry and biophysics 1996;330(2):419-29.
1996: Patricia C Chulada; Charles D Loftin; V D Winn; D A Young; Howard F Tiano; Thomas E Eling; R Langenbach
Relative activities of retrovirally expressed murine prostaglandin synthase-1 and -2 depend on source of arachidonic acid.
Archives of biochemistry and biophysics 1996;330(2):301-13.
1996: Wayne C Glasgow; Elizabeth Mary Hill; S R McGown; Kenneth B Tomer; Thomas E Eling
Regulation of 13(S)-hydroxyoctadecadienoic acid biosynthesis in Syrian hamster embryo fibroblasts by the epidermal growth factor receptor tyrosine kinase.
Molecular pharmacology 1996;49(6):1042-8.
1996: Elizabeth Mary Hill; T Bader; Paul Nettesheim; Thomas E Eling
Retinoid-induced differentiation regulates prostaglandin H synthase and cPLA2 expression in tracheal epithelium.
The American journal of physiology 1996;270(5 Pt 1):L854-62.
1996: R Palmantier; J D Roberts; Wayne C Glasgow; Thomas E Eling; K Olden
Regulation of the adhesion of a human breast carcinoma cell line to type IV collagen and vitronectin: roles for lipoxygenase and protein kinase C.
Cancer research 1996;56(9):2206-12.
1995: Rutai Hui; J F Curtis; M T Sumner; Stephen B Shears; Wayne C Glasgow; Thomas E Eling
Human immunodeficiency virus type 1 envelope protein does not stimulate either prostaglandin formation or the expression of prostaglandin H synthase in THP-1 human monocytes/macrophages.
Journal of virology 1995;69(12):8020-6.
1995: J F Curtis; Kenneth B Tomer; S McGown; Thomas E Eling
Prostaglandin H synthase-catalyzed ring oxygenation of 2-naphthylamine: evidence for two distinct oxidation pathways.
Chemical research in toxicology 1995;8(6):875-83.
1995: Y Hamasaki; Thomas E Eling
EGF and TPA stimulate de novo synthesis of PGHS-1 and PGHS-2 through different signal transduction pathways.
Prostaglandins, leukotrienes, and essential fatty acids 1995;53(3):225-9.
1995: Julie Angerman-Stewart; Thomas E Eling; Wayne C Glasgow
Prostaglandin H synthase-2 is induced in Syrian hamster embryo cells in response to basic fibroblast growth factor.
Archives of biochemistry and biophysics 1995;318(2):378-86.
1995: J Kitzler; E Hill; R Hardman; N Reddy; RM Philpot; Thomas E Eling
Analysis and quantitation of splicing variants of the TPA-inducible PGHS-1 mRNA in rat tracheal epithelial cells.
Archives of biochemistry and biophysics 1995;316(2):856-63.
1995: Thomas E Eling; Angela L Everhart; Wayne C Glasgow
Modulation of EGF cell signaling tyrosine phosphorylation by linoleic acid metabolites.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():453-5.
1994: Thomas E Eling; Wayne C Glasgow
Cellular proliferation and lipid metabolism: importance of lipoxygenases in modulating epidermal growth factor-dependent mitogenesis.
Cancer metastasis reviews 1994;13(3-4):397-410.
1994: Wayne C Glasgow; Thomas E Eling
Structure-activity relationship for potentiation of EGF-dependent mitogenesis by oxygenated metabolites of linoleic acid.
Archives of biochemistry and biophysics 1994;311(2):286-92.
1993: M S Cowlen; Thomas E Eling
Effects of prostaglandins and hydroxyoctadecadienoic acid on epidermal growth factor-dependent DNA synthesis and c-myc proto-oncogene expression in Syrian hamster embryo cells.
Biochimica et biophysica acta 1993;1174(3):234-40.
1993: Y Hamasaki; J Kitzler; R Hardman; P Nettesheim; Thomas E Eling
Phorbol ester and epidermal growth factor enhance the expression of two inducible prostaglandin H synthase genes in rat tracheal epithelial cells.
Archives of biochemistry and biophysics 1993;304(1):226-34.
1993: L D Morrison; Thomas E Eling; P David Josephy
Prostaglandin H synthase-dependent formation of the direct-acting mutagen 2-nitro-3-methylimidazo[4,5-f]quinoline (nitro-IQ) from IQ.
Mutation research 1993;302(1):45-52.
1992: M S Cowlen; Thomas E Eling
Modulation of c-jun and jun-B messenger RNA and inhibition of DNA synthesis by prostaglandin E2 in Syrian hamster embryo cells.
Cancer research 1992;52(24):6912-6.
1992: J A DeGray; G Lassmann; J F Curtis; T A Kennedy; Lawrence J Marnett; Thomas E Eling; Ronald P Mason
Spectral analysis of the protein-derived tyrosyl radicals from prostaglandin H synthase.
The Journal of biological chemistry 1992;267(33):23583-8.
1992: Wayne C Glasgow; Cynthia A Afshari; J Carl Barrett; Thomas E Eling
Modulation of the epidermal growth factor mitogenic response by metabolites of linoleic and arachidonic acid in Syrian hamster embryo fibroblasts. Differential effects in tumor suppressor gene (+) and (-) phenotypes.
The Journal of biological chemistry 1992;267(15):10771-9.
1992: D C Thompson; P David Josephy; J W Chu; Thomas E Eling
Enhanced mutagenicity of anisidine isomers in bacterial strains containing elevated N-acetyltransferase activity.
Mutation research 1992;279(2):83-9.
1992: B J Smith; Lillian S DeBruin; P David Josephy; Thomas E Eling
Mutagenic activation of benzidine requires prior bacterial acetylation and subsequent conversion by prostaglandin H synthase to 4-nitro-4'-(acetylamino)biphenyl.
Chemical research in toxicology 1992;5(3):431-9.
1992: M F Hughes; B J Smith; Thomas E Eling
The oxidation of 4-aminobiphenyl by horseradish peroxidase.
Chemical research in toxicology 1992;5(3):340-5.
1992: G L Foureman; K T Knecht; Thomas E Eling
Peroxidase-mediated glutathione conjugation of benzo[a]pyrene-7,8-dihydrodiol is enhanced by benzo[a]pyrene phenols in vitro.
Carcinogenesis 1992;13(4):515-8.
1992: Thomas E Eling; J F Curtis
Xenobiotic metabolism by prostaglandin H synthase.
Pharmacology & therapeutics 1992;53(2):261-73.
1991: G Lassmann; R Odenwaller; J F Curtis; J A DeGray; Ronald P Mason; Lawrence J Marnett; Thomas E Eling
Electron spin resonance investigation of tyrosyl radicals of prostaglandin H synthase. Relation to enzyme catalysis.
The Journal of biological chemistry 1991;266(30):20045-55.
1991: W Chamulitrat; M F Hughes; Thomas E Eling; Ronald P Mason
Superoxide and peroxyl radical generation from the reduction of polyunsaturated fatty acid hydroperoxides by soybean lipoxygenase.
Archives of biochemistry and biophysics 1991;290(1):153-9.
1991: Thomas E Eling; Wayne C Glasgow; J F Curtis; Walter Hubbard; J A Handler
Studies on the reduction of endogenously generated prostaglandin G2 by prostaglandin H synthase.
The Journal of biological chemistry 1991;266(19):12348-55.
1991: D C Thompson; Thomas E Eling
Reactive intermediates formed during the peroxidative oxidation of anisidine isomers.
Chemical research in toxicology 1991;4(4):474-81.
1991: Z M Duniec; P Nettesheim; Thomas E Eling
Stimulation of prostaglandin H synthase mRNA levels and prostaglandin biosynthesis by phorbol ester: mediation by protein kinase C.
Molecular pharmacology 1991;39(2):164-70.
1991: Thomas E Eling; Wayne C Glasgow
Transduction of the epidermal growth factor mitogenic signal in BALB/c 3T3 fibroblasts involves linoleic acid metabolism.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21B():843-6.
1990: Wayne C Glasgow; Thomas E Eling
Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts.
Molecular pharmacology 1990;38(4):503-10.
1990: J A Handler; R M Danilowicz; Thomas E Eling
Mitogenic signaling by epidermal growth factor (EGF), but not platelet-derived growth factor, requires arachidonic acid metabolism in BALB/c 3T3 cells. Modulation of EGF-dependent c-myc expression by prostaglandins.
The Journal of biological chemistry 1990;265(7):3669-73.
1990: Thomas E Eling; D C Thompson; G L Foureman; J F Curtis; M F Hughes
Prostaglandin H synthase and xenobiotic oxidation.
Annual review of pharmacology and toxicology 1990;30():1-45.
1989: T W Petry; P David Josephy; D A Pagano; E Zeiger; K T Knecht; Thomas E Eling
Prostaglandin hydroperoxidase-dependent activation of heterocyclic aromatic amines.
Carcinogenesis 1989;10(12):2201-7.
1989: J Van der Zee; D R Duling; Ronald P Mason; Thomas E Eling
The oxidation of N-substituted aromatic amines by horseradish peroxidase.
The Journal of biological chemistry 1989;264(33):19828-36.
1989: M F Hughes; W Chamulitrat; Ronald P Mason; Thomas E Eling
Epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene via a hydroperoxide-dependent mechanism catalyzed by lipoxygenases.
Carcinogenesis 1989;10(11):2075-80.
1989: D Thompson; Thomas E Eling
Mechanism of inhibition of prostaglandin H synthase by eugenol and other phenolic peroxidase substrates.
Molecular pharmacology 1989;36(5):809-17.
1989: J Van der Zee; Thomas E Eling; Ronald P Mason
Formation of free radical metabolites in the reaction between soybean lipoxygenase and its inhibitors. An ESR study.
Biochemistry 1989;28(21):8363-7.
1989: T A Bertram; L H Overby; Arnold R Brody; Thomas E Eling
Comparison of arachidonic acid metabolism by pulmonary intravascular and alveolar macrophages exposed to particulate and soluble stimuli.
Laboratory investigation; a journal of technical methods and pathology 1989;61(4):457-66.
1989: J Van der Zee; Ronald P Mason; Thomas E Eling
The oxidation of the calcium probe quin2 and its analogs by prostaglandin H synthase.
Archives of biochemistry and biophysics 1989;271(1):64-71.
1989: R M Danilowicz; G Reed; D R Germolec; Michael I Luster; Kenneth B Tomer; J F Curtis; T Higuchi; Thomas E Eling
12S,19- and 12S,20-dihydroxyeicosanoids: novel 12S-hydroxy-5,8-cis-10-trans-14-cis-eicosatetraenoic acid metabolites formed by hydroxylation and reduction in murine lymphocytes.
Archives of biochemistry and biophysics 1989;271(1):72-83.
1989: J Schreiber; G L Foureman; M F Hughes; Ronald P Mason; Thomas E Eling
Detection of glutathione thiyl free radical catalyzed by prostaglandin H synthase present in keratinocytes. Study of co-oxidation in a cellular system.
The Journal of biological chemistry 1989;264(14):7936-43.
1989: G L Foureman; Thomas E Eling
Peroxidase-mediated formation of glutathione conjugates from polycyclic aromatic dihydrodiols and insecticides.
Archives of biochemistry and biophysics 1989;269(1):55-68.
1989: P David Josephy; A L Chiu; Thomas E Eling
Prostaglandin H synthase-dependent mutagenic activation of benzidine in a Salmonella typhimurium Ames tester strain possessing elevated N-acetyltransferase levels.
Cancer research 1989;49(4):853-6.
1989: R S Krauss; Julie Angerman-Stewart; Thomas E Eling; K L Dooley; Fred F Kadlubar
The formation of 2-aminofluorene-DNA adducts in vivo: evidence for peroxidase-mediated activation.
Journal of biochemical toxicology 1989;4(2):111-7.
1989: S J Vore; Thomas E Eling; M Danilowicz; A N Tucker; Michael I Luster
Regulation of murine hematopoiesis by arachidonic acid metabolites.
International journal of immunopharmacology 1989;11(5):435-42.
1988: David Henke; R M Danilowicz; J F Curtis; Richard C Boucher; Thomas E Eling
Metabolism of arachidonic acid by human nasal and bronchial epithelial cells.
Archives of biochemistry and biophysics 1988;267(2):426-36.
1988: J F Curtis; M F Hughes; Ronald P Mason; Thomas E Eling
Peroxidase-catalyzed oxidation of (bi)sulfite: reaction of free radical metabolites of (bi)sulfite with (+/-)-7,8-dihydroxy-7, 8-dihydroxy[a]pyrene.
Carcinogenesis 1988;9(11):2015-21.
1988: T A Bertram; L H Overby; R Danilowicz; Thomas E Eling; Arnold R Brody
Pulmonary intravascular macrophages metabolize arachidonic acid in vitro. Comparison with alveolar macrophages.
The American review of respiratory disease 1988;138(4):936-44.
1988: R D Nolan; R M Danilowicz; Thomas E Eling
Role of arachidonic acid metabolism in the mitogenic response of BALB/c 3T3 fibroblasts to epidermal growth factor.
Molecular pharmacology 1988;33(6):650-6.
1988: T A Bertram; L H Overby; R Danilowicz; Thomas E Eling; Arnold R Brody
Pulmonary intravascular macrophages produce prostaglandins and leukotrienes in vitro.
Chest 1988;93(3 Suppl):82S-84S.
1988: T W Petry; Thomas E Eling; A L Chiu; P David Josephy
Ram seminal vesicle microsome-catalyzed activation of benzidine and related compounds: dissociation of mutagenesis from peroxidase-catalyzed formation of DNA-reactive material.
Carcinogenesis 1988;9(1):51-7.
1988: Thomas E Eling; David Henke; R Danilowicz
Arachidonic acid metabolism in respiratory epithelial cells.
General pharmacology 1988;19(3):313-6.
1988: S Kouzan; R D Nolan; T Fournier; J Bignon; Thomas E Eling; Arnold R Brody
Stimulation of arachidonic acid metabolism by adherence of alveolar macrophages to a plastic substrate. Modulation by fetal bovine serum.
The American review of respiratory disease 1988;137(1):38-43.
1987: T W Petry; Thomas E Eling
The mechanism for the inhibition of prostaglandin H synthase-catalyzed xenobiotic oxidation by methimazole. Reaction with free radical oxidation products.
The Journal of biological chemistry 1987;262(29):14112-8.
1986: Thomas E Eling; R M Danilowicz; David Henke; K Sivarajah; James R Yankaskas; Richard C Boucher
Arachidonic acid metabolism by canine tracheal epithelial cells. Product formation and relationship to chloride secretion.
The Journal of biological chemistry 1986;261(27):12841-9.
1986: D Henke; R Danilowicz; Thomas E Eling
Arachidonic acid metabolism by isolated epidermal basal and differentiated keratinocytes from the hairless mouse.
Biochimica et biophysica acta 1986;876(2):271-9.
1985: Michael I Luster; A N Tucker; H T Hayes; O J Pung; T Burka; R McMillan; Thomas E Eling
Immunosuppressive effects of benzidine in mice: evidence of alterations in arachidonic acid metabolism.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(4):2754-61.