FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Stephen Elledge

Research Profile

Chemicals & Drugs

Disorders

DNA Damage

Concepts & Ideas

Molecular Sequence Data

Living Beings

Physiology

Co-author Network

Publications

TOP 3
H Benjamin Larman; Stephen J Elledge; Anthony A Amato; Theresa Lam; Remedios Nazareno; Jack L Pinkus; Mohammad Salajegheh; John Sauld; Hanno Steen; Sek Won Kong; Steven A Greenberg
Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis.
Nicole L Solimini; Kwok-Kin Wong; Chunxiao Xu; Qikai Xu; Teresa Davoli; Mamie Z Li; Anthony C Liang; Natalya N Pavlova; Stephen J Elledge
STOP gene Phactr4 is a tumor suppressor.
H Benjamin Larman; Natalya N Pavlova; George Jing Xu; Stephen J Elledge
Construction of a rationally designed antibody platform for sequencing-assisted selection.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Stephen Elledge (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: H Benjamin Larman; Stephen J Elledge; Anthony A Amato; Theresa Lam; Remedios Nazareno; Jack L Pinkus; Mohammad Salajegheh; John Sauld; Hanno Steen; Sek Won Kong; Steven A Greenberg
Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis.
Annals of neurology 2013;73(3):408-18.
2013: Nicole L Solimini; Kwok-Kin Wong; Chunxiao Xu; Qikai Xu; Teresa Davoli; Mamie Z Li; Anthony C Liang; Natalya N Pavlova; Stephen J Elledge
STOP gene Phactr4 is a tumor suppressor.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):E407-14.
2012: H Benjamin Larman; Natalya N Pavlova; George Jing Xu; Stephen J Elledge
Construction of a rationally designed antibody platform for sequencing-assisted selection.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(45):18523-8.
2012: Xu Tan; Ruibin Xi; Geng Gao; Long Hu; Yifang Liu; Zhi John Lu; Lovelace J Luquette; Peter J Park; Hongjing Qu; Stephen J Elledge
Systematic identification of synergistic drug pairs targeting HIV.
Nature biotechnology 2012;30(11):1125-30.
2012: Alberto Ciccia; Yathish Jagadheesh Achar; Britt Adamson; Ildiko Hajdu; Lajos Haracska; Yiduo Hu; Lior Izhar; Stephen C Kowalczykowski; David M Livingston; Amitabh V Nimonkar; Sarah A Petit; John C Yoon; Stephen J Elledge
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
Molecular cell 2012;47(3):396-409.
2012: Nicole L Solimini; Qikai Xu; Anthony N Anselmo; Rameen Beroukhim; Andrea L Bredemeyer; Anna E Burrows; Mamie Z Li; Anthony C Liang; Ji Luo; Craig H Mermel; Matthew Meyerson; Michael R Schlabach; Stephen J Elledge
Recurrent hemizygous deletions in cancers may optimize proliferative potential.
Science (New York, N.Y.) 2012;337(6090):104-9.
2012: Britt Adamson; Randall W King; Frederic Sigoillot; Agata Smogorzewska; Stephen J Elledge
A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.
Nature cell biology 2012;14(3):318-28.
2012: Jessica D Kessler; Mamie Z Li; Anthony C Liang; Ji Luo; Kristen L Meerbrey; C Kent Osborne; Mitchell Rao; Rachel Schiff; Michael R Schlabach; Earlene M Schmitt; Chad A Shaw; Samuel O Skinner; Nicole L Solimini; Tingting Sun; Ronald J Bernardi; Chad J Creighton; Rocio Dominguez-Vidana; Stephen J Elledge; Ido Golding; Zachary Conrad Hartman; Susan G Hilsenbeck; Tiffany Hsu; Kristopher T Kahle; Qikai Xu; Bing Yu; Peng Yu; Thomas F Westbrook
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.
Science (New York, N.Y.) 2012;335(6066):348-53.
2012: Andrew E H Elia; Stephen J Elledge
BRCA1 as tumor suppressor: lord without its RING?
Breast cancer research : BCR 2012;14(2):306.
2012: Mamie Z Li; Stephen J Elledge
SLIC: a method for sequence- and ligation-independent cloning.
Methods in molecular biology (Clifton, N.J.) 2012;852():51-9.
2011: Woo Joo; Olga Buzovetsky; Stephen J Elledge; Nicole S Persky; Derek G Rudge; Agata Smogorzewska; Guozhou Xu; Nikola P Pavletich
Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway.
Science (New York, N.Y.) 2011;333(6040):312-6.
2011: Cecilia Cotta-Ramusino; J Wade Harper; Kristen Hurov; E Robert McDonald; Mathew E Sowa; Stephen J Elledge
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.
Science (New York, N.Y.) 2011;332(6035):1313-7.
2011: Tingting Sun; Nicola Aceto; Kristen L Meerbrey; Jessica D Kessler; Chunshui Zhou; Ilenia Migliaccio; Don X Nguyen; Natalya N Pavlova; Maria Botero; Jian Huang; Ronald J Bernardi; Earlene Schmitt; Guang Hu; Mamie Z Li; Noah Dephoure; Steven P Gygi; Mitchell Rao; Chad J Creighton; Susan G Hilsenbeck; Chad A Shaw; Donna Muzny; Richard A Gibbs; David A Wheeler; C Kent Osborne; Rachel Schiff; Mohamed Bentires-Alj; Stephen J Elledge; Thomas F Westbrook
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.
Cell 2011;144(5):703-18.
2011: Kristen L Meerbrey; Guang Hu; Jessica D Kessler; Kevin Roarty; Mamie Z Li; Justin E Fang; Jason I Herschkowitz; Anna E Burrows; Alberto Ciccia; Tingting Sun; Earlene M Schmitt; Ronald J Bernardi; Xiaoyong Fu; Christopher S Bland; Thomas A Cooper; Rachel Schiff; Jeffrey M Rosen; Thomas F Westbrook; Stephen J Elledge
The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(9):3665-70.
2011: I-Chueh Huang; Charles C Bailey; Jessica L Weyer; Sheli R Radoshitzky; Michelle M Becker; Jessica J Chiang; Abraham L Brass; Asim A Ahmed; Xiaoli Chi; Lian Dong; Lindsay E Longobardi; Dutch Boltz; Jens H Kuhn; Stephen J Elledge; Sina Bavari; Mark R Denison; Hyeryun Choe; Michael Farzan
Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.
PLoS pathogens 2011;7(1):e1001258.
2010: Brenda C O'Connell; Britt Adamson; John R Lydeard; Mathew E Sowa; Alberto Ciccia; Andrea L Bredemeyer; Michael Schlabach; Steven P Gygi; Stephen J Elledge; J Wade Harper
A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.
Molecular cell 2010;40(4):645-57.
2010: Danny M Chou; Britt Adamson; Noah E Dephoure; Xu Tan; Amanda C Nottke; Kristen E Hurov; Steven P Gygi; Monica P Colaiácovo; Stephen J Elledge
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(43):18475-80.
2010: Kristen E Hurov; Cecilia Cotta-Ramusino; Stephen J Elledge
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.
Genes & development 2010;24(17):1939-50.
2010: Anna E Burrows; Agata Smogorzewska; Stephen J Elledge
Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14280-5.
2010: Agata Smogorzewska; Rohini Desetty; Takamune T Saito; Michael Schlabach; Francis P Lach; Mathew E Sowa; Alan B Clark; Thomas A Kunkel; J Wade Harper; Monica P Colaiácovo; Stephen J Elledge
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Molecular cell 2010;39(1):36-47.
2009: Puck Knipscheer; Markus Räschle; Agata Smogorzewska; Milica Enoiu; The Vinh Ho; Orlando D Schärer; Stephen J Elledge; Johannes C Walter
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.
Science (New York, N.Y.) 2009;326(5960):1698-701.
2009: Alberto Ciccia; Andrea L Bredemeyer; Mathew E Sowa; Marie-Emilie Terret; Prasad V Jallepalli; J Wade Harper; Stephen J Elledge
The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart.
Genes & development 2009;23(20):2415-25.
2009: Maria L Naylor; Ju-mei Li; Alex J Osborn; Stephen J Elledge
Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12765-70.
2009: Jennifer M Svendsen; Agata Smogorzewska; Mathew E Sowa; Brenda C. O'Connell; Steven P Gygi; Stephen J Elledge; J Wade Harper
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Cell 2009;138(1):63-77.
2009: Ji Luo; Michael J Emanuele; Danan Li; Chad J Creighton; Michael R Schlabach; Thomas F Westbrook; Kwok-Kin Wong; Stephen J Elledge
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.
Cell 2009;137(5):835-48.
2009: Guang Hu; Jonghwan Kim; Qikai Xu; Yumei Leng; Stuart H Orkin; Stephen J Elledge
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal.
Genes & development 2009;23(7):837-48.
2009: Ji Luo; Nicole L Solimini; Stephen J Elledge
Principles of cancer therapy: oncogene and non-oncogene addiction.
Cell 2009;136(5):823-37.
2009: Qikai Xu; Michael R Schlabach; Gregory J Hannon; Stephen J Elledge
Design of 240,000 orthogonal 25mer DNA barcode probes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(7):2289-94.
2008: Peter Mulligan; Thomas F Westbrook; Matthias Ottinger; Natalya Pavlova; Bin Chang; Eric Macia; Yu-Jiang Shi; Jordi Barretina; Jinsong Liu; Peter M Howley; Stephen J Elledge; Yang Shi
CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.
Molecular cell 2008;32(5):718-26.
2008: Spencer J Collis; Alberto Ciccia; Andrew Deans; Zuzana Horejsí; Julie S Martin; Sarah Maslen; J Mark Skehel; Stephen J Elledge; Stephen C West; Simon J Boulton
FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex.
Molecular cell 2008;32(3):313-24.
2008: Hsueh-Chi Sherry Yen; Stephen J Elledge
Identification of SCF ubiquitin ligase substrates by global protein stability profiling.
Science (New York, N.Y.) 2008;322(5903):923-9.
2008: Hsueh-Chi Sherry Yen; Qikai Xu; Danny M Chou; Zhenming Zhao; Stephen J Elledge
Global protein stability profiling in mammalian cells.
Science (New York, N.Y.) 2008;322(5903):918-23.
2008: Masamichi Ishiai; Hiroyuki Kitao; Agata Smogorzewska; Junya Tomida; Aiko Kinomura; Emi Uchida; Alihossein Saberi; Eiji Kinoshita; Emiko Kinoshita-Kikuta; Tohru Koike; Satoshi Tashiro; Stephen J Elledge; Minoru Takata
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.
Nature structural & molecular biology 2008;15(11):1138-46.
2008: Yang David Lee; Jun Wang; JoAnne Stubbe; Stephen J Elledge
Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.
Molecular cell 2008;32(1):70-80.
2008: Manoj N Krishnan; Aylwin Ng; Bindu Sukumaran; Felicia D Gilfoy; Pradeep D Uchil; Hameeda Sultana; Abraham L Brass; Rachel Adametz; Melody Tsui; Qian Feng; Ruth R Montgomery; Sima Lev; Peter W Mason; Raymond A Koski; Stephen J Elledge; Ramnik Xavier; Hervé Agaisse; Erol Fikrig
RNA interference screen for human genes associated with West Nile virus infection.
Nature 2008;455(7210):242-5.
2008: Noah Dephoure; Chunshui Zhou; Judit Villén; Sean A Beausoleil; Corey E Bakalarski; Stephen J Elledge; Steven P Gygi
A quantitative atlas of mitotic phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10762-7.
2008: Ji Luo; Stephen J Elledge
Cancer: Deconstructing oncogenesis.
Nature 2008;453(7198):995-6.
2008: Anna E Burrows; Stephen J Elledge
How ATR turns on: TopBP1 goes on ATRIP with ATR.
Genes & development 2008;22(11):1416-21.
2008: Thomas F Westbrook; Guang Hu; Xiaolu L Ang; Peter Mulligan; Natalya N Pavlova; Anthony Liang; Yumei Leng; Rene Maehr; Yang Shi; J Wade Harper; Stephen J Elledge
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.
Nature 2008;452(7185):370-4.
2008: Abraham L Brass; Derek M. Dykxhoorn; Yair Benita; Nan Yan; Alan Engelman; Ramnik Xavier; Judy Lieberman; Stephen J Elledge
Identification of host proteins required for HIV infection through a functional genomic screen.
Science (New York, N.Y.) 2008;319(5865):921-6.
2008: Michael R Schlabach; Ji Luo; Nicole L Solimini; Guang Hu; Qikai Xu; Mamie Z Li; Zhenming Zhao; Agata Smogorzewska; Mathew E Sowa; Xiaolu L Ang; Thomas F Westbrook; Anthony C Liang; Kenneth Chang; Jennifer A Hackett; J Wade Harper; Gregory J Hannon; Stephen J Elledge
Cancer proliferation gene discovery through functional genomics.
Science (New York, N.Y.) 2008;319(5863):620-4.
2008: Jose M Silva; Krista Marran; Joel Parker; Javier Silva; Michael Golding; Michael R Schlabach; Stephen J Elledge; Gregory J Hannon; Kenneth Chang
Profiling essential genes in human mammary cells by multiplex RNAi screening.
Science (New York, N.Y.) 2008;319(5863):617-20.
2007: J Wade Harper; Stephen J Elledge
The DNA damage response: ten years after.
Molecular cell 2007;28(5):739-45.
2007: Grant S Stewart; Tatjana Stankovic; Philip J Byrd; Thomas Wechsler; Edward S Miller; Aarn Huissoon; Mark T Drayson; Stephen C West; Stephen J Elledge; A Malcolm R Taylor
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):16910-5.
2007: Frank Stegmeier; Mathew E Sowa; Grzegorz Nalepa; Steven P Gygi; J Wade Harper; Stephen J Elledge
The tumor suppressor CYLD regulates entry into mitosis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8869-74.
2007: Viji M Draviam; Frank Stegmeier; Grzegorz Nalepa; Mathew E Sowa; Jing Chen; Anthony Liang; Gregory J Hannon; Peter K Sorger; J Wade Harper; Stephen J Elledge
A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.
Nature cell biology 2007;9(5):556-64.
2007: Frank Stegmeier; Michael Rape; Viji M Draviam; Grzegorz Nalepa; Mathew E Sowa; Xiaolu L Ang; E Robert McDonald; Mamie Z Li; Gregory J Hannon; Peter K Sorger; Marc W Kirschner; J Wade Harper; Stephen J Elledge
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.
Nature 2007;446(7138):876-81.
2007: Mamie Z Li; Stephen J Elledge
Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC.
Nature methods 2007;4(3):251-6.
2006: Kenneth Chang; Stephen J Elledge; Gregory J Hannon
Lessons from Nature: microRNA-based shRNA libraries.
Nature methods 2006;3(9):707-14.
2006: Dong Zhang; Kathrin Zaugg; Tak W Mak; Stephen J Elledge
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response.
Cell 2006;126(3):529-42.
2006: Yang David Lee; Stephen J Elledge
Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1.
Genes & development 2006;20(3):334-44.
2005: Andrew S Turnell; Grant S Stewart; Roger J A Grand; Susan M Rookes; Ashley Martin; Hiroyuki Yamano; Stephen J Elledge; Phillip H Gallimore
The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.
Nature 2005;438(7068):690-5.
2005: Melissa M Adams; Bin Wang; Zhenfang Xia; Julio Cesar Morales; Xiongbin Lu; Lawrence A Donehower; Daniel Bochar; Stephen J Elledge; Phillip B Carpenter
53BP1 oligomerization is independent of its methylation by PRMT1.
Cell cycle (Georgetown, Tex.) 2005;4(12):1854-61.
2005: Jose M Silva; Mamie Z Li; Kenneth Chang; Wei Ge; Michael C Golding; Richard J Rickles; Despina Siolas; Guang Hu; Patrick J Paddison; Michael R Schlabach; Nihar Sheth; Jeff Bradshaw; Julja Burchard; Amit Kulkarni; Guy Cavet; Ravi Sachidanandam; W Richard McCombie; Michele A Cleary; Stephen J Elledge; Gregory J Hannon
Second-generation shRNA libraries covering the mouse and human genomes.
Nature genetics 2005;37(11):1281-8.
2005: Frank Stegmeier; Guang Hu; Richard J Rickles; Gregory J Hannon; Stephen J Elledge
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(37):13212-7.
2005: Thomas F Westbrook; Eric S Martin; Michael R Schlabach; Yumei Leng; Anthony C Liang; Bin Feng; Jean J Zhao; Thomas M Roberts; Gail Mandel; Gregory J Hannon; Ronald A DePinho; Lynda Chin; Stephen J Elledge
A genetic screen for candidate tumor suppressors identifies REST.
Cell 2005;121(6):837-48.
2005: Mamie Z Li; Stephen J Elledge
MAGIC, an in vivo genetic method for the rapid construction of recombinant DNA molecules.
Nature genetics 2005;37(3):311-9.
2005: T F Westbrook; Frank Stegmeier; Stephen J Elledge
Dissecting cancer pathways and vulnerabilities with RNAi.
Cold Spring Harbor symposia on quantitative biology 2005;70():435-44.
2005: Ju-mei Li; Yumei Li; Stephen J Elledge
Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the ras/protein kinase A pathway and a novel subunit required for Ask1 association.
Molecular and cellular biology 2005;25(2):767-78.
2004: Xin Ye; Grzegorz Nalepa; Markus Welcker; Benedikt M Kessler; Eric Spooner; Jun Qin; Stephen J Elledge; Bruce E Clurman; J Wade Harper
Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.
The Journal of biological chemistry 2004;279(48):50110-9.
2004: Michael H. Lam; Qinghua Liu; Stephen J Elledge; Jeffrey M Rosen
Chk1 is haploinsufficient for multiple functions critical to tumor suppression.
Cancer cell 2004;6(1):45-59.
2004: Shiaw-Yih Lin; Kaiyi Li; Grant S Stewart; Stephen J Elledge
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6484-9.
2004: Patrick J Paddison; Jose M Silva; Douglas S Conklin; Michael R Schlabach; Mamie Li; Shola Aruleba; Vivekanand Balija; Andrew O'Shaughnessy; Lidia Gnoj; Kim Scobie; Kenneth Chang; Thomas Westbrook; Michele Cleary; Ravi Sachidanandam; W Richard McCombie; Stephen J Elledge; Gregory J Hannon
A resource for large-scale RNA-interference-based screens in mammals.
Nature 2004;428(6981):427-31.
2004: Michael T Tetzlaff; Wei Yu; Mamie Li; Pumin Zhang; Milton Finegold; Kathleen A Mahon; J Wade Harper; Robert J Schwartz; Stephen J Elledge
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3338-45.
2004: Michael T Tetzlaff; Chang Bai; Milton Finegold; John Wilson; J Wade Harper; Kathleen A Mahon; Stephen J Elledge
Cyclin F disruption compromises placental development and affects normal cell cycle execution.
Molecular and cellular biology 2004;24(6):2487-98.
2003: Jianping Jin; Takahiro Shirogane; Lai Xu; Grzegorz Nalepa; Jun Qin; Stephen J Elledge; J Wade Harper
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.
Genes & development 2003;17(24):3062-74.
2003: Emily Bernstein; Sang Yong Kim; Michelle A Carmell; Elizabeth P Murchison; Heather L Alcorn; Mamie Z Li; Alea A Mills; Stephen J Elledge; Kathryn V Anderson; Gregory J Hannon
Dicer is essential for mouse development.
Nature genetics 2003;35(3):215-7.
2003: Lai Xu; Yue Wei; Jerome Reboul; Philippe Vaglio; Tae-Ho Shin; Marc Vidal; Stephen J Elledge; J Wade Harper
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.
Nature 2003;425(6955):316-21.
2003: Alexander J Osborn; Stephen J Elledge
Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.
Genes & development 2003;17(14):1755-67.
2003: Shiaw-Yih Lin; Stephen J Elledge
Multiple tumor suppressor pathways negatively regulate telomerase.
Cell 2003;113(7):881-9.
2003: Lee Zou; Stephen J Elledge
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.
Science (New York, N.Y.) 2003;300(5625):1542-8.
2003: Julio Cesar Morales; Zhenfang Xia; Tao Lu; Melissa B Aldrich; Bin Wang; Corina Rosales; Rodney E Kellems; Walter N Hittelman; Stephen J Elledge; Phillip B Carpenter
Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability.
The Journal of biological chemistry 2003;278(17):14971-7.
2003: Yanchang Wang; Takahiro Shirogane; Dou Liu; J Wade Harper; Stephen J Elledge
Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling.
Cell 2003;112(5):697-709.
2003: Yumei Li; Stephen J Elledge
The DASH complex component Ask1 is a cell cycle-regulated Cdk substrate in Saccharomyces cerevisiae.
Cell cycle (Georgetown, Tex.) 2003;2(2):143-8.
2003: Grant S Stewart; Bin Wang; Colin R Bignell; A Malcolm R Taylor; Stephen J Elledge
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Nature 2003;421(6926):961-6.
2002: Bin Wang; Shuhei Matsuoka; Phillip B Carpenter; Stephen J Elledge
53BP1, a mediator of the DNA damage checkpoint.
Science (New York, N.Y.) 2002;298(5597):1435-8.
2002: Alexander J Osborn; Stephen J Elledge; Lee Zou
Checking on the fork: the DNA-replication stress-response pathway.
Trends in cell biology 2002;12(11):509-16.
2002: John H Wilson; Stephen J Elledge
Cancer. BRCA2 enters the fray.
Science (New York, N.Y.) 2002;297(5588):1822-3.
2002: Fenghua Hu; Stephen J Elledge
Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints.
Cell cycle (Georgetown, Tex.) 2002;1(5):351-5.
2002: Grant Stewart; Stephen J Elledge
The two faces of BRCA2, a FANCtastic discovery.
Molecular cell 2002;10(1):2-4.
2002: Jeff Bachant; Annette A Alcasabas; Yuval Blat; Nancy Kleckner; Stephen J Elledge
The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II.
Molecular cell 2002;9(6):1169-82.
2002: Ning Zheng; Brenda A Schulman; Langzhou Song; Julie J Miller; Philip Jeffrey; Ping Wang; Claire Chu; Deanna M Koepp; Stephen J Elledge; Michele Pagano; Ronald C Conaway; Joan Weliky Conaway; J Wade Harper; Nikola P Pavletich
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature 2002;416(6882):703-9.
2002: Hong Wang; Stephen J Elledge
Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway.
Genetics 2002;160(4):1295-304.
2002: Lee Zou; David Cortez; Stephen J Elledge
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin.
Genes & development 2002;16(2):198-208.
2002: Yumei Li; Jeff Bachant; Annette A Alcasabas; Yanchang Wang; Jun Qin; Stephen J Elledge
The mitotic spindle is required for loading of the DASH complex onto the kinetochore.
Genes & development 2002;16(2):183-97.
2002: Pumin Zhang; Mamei Z Li; Stephen J Elledge
Towards genetic genome projects: genomic library screening and gene-targeting vector construction in a single step.
Nature genetics 2002;30(1):31-9.
2001: Fenghua Hu; Yanchang Wang; Dou Liu; Yumei Li; Jun Qin; Stephen J Elledge
Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints.
Cell 2001;107(5):655-65.
2001: David Cortez; S Guntuku; Jun Qin; Stephen J Elledge
ATR and ATRIP: partners in checkpoint signaling.
Science (New York, N.Y.) 2001;294(5547):1713-6.
2001: Annette A Alcasabas; A J Osborn; Jeff Bachant; Fenghua Hu; Petra J H Werler; Kristine Bousset; K Furuya; John F X Diffley; Antony M Carr; Stephen J Elledge
Mrc1 transduces signals of DNA replication stress to activate Rad53.
Nature cell biology 2001;3(11):958-65.
2001: Deanna M Koepp; L K Schaefer; Xin Ye; Khandan Keyomarsi; Claire Chu; J Wade Harper; Stephen J Elledge
Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.
Science (New York, N.Y.) 2001;294(5540):173-7.
2001: H Wang; Dou Liu; Yanchang Wang; Jun Qin; Stephen J Elledge
Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function.
Genes & development 2001;15(11):1361-72.
2001: Fenghua Hu; Annette A Alcasabas; Stephen J Elledge
Asf1 links Rad53 to control of chromatin assembly.
Genes & development 2001;15(9):1061-6.
2000: Brenda A Schulman; Andrea C. Carrano; Philip Jeffrey; Z Bowen; Elspeth Kinnucan; Michael S Finnin; Stephen J Elledge; J Wade Harper; Michele Pagano; Nikola P Pavletich
Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Nature 2000;408(6810):381-6.
2000: Yanchang Wang; Fenghua Hu; Stephen J Elledge
The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit.
Current biology : CB 2000;10(21):1379-82.
2000: S Matsuoka; Galit Rotman; A Ogawa; Yosef Shiloh; Katsuyuki Tamai; Stephen J Elledge
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10389-94.
2000: Q Liu; S Guntuku; XS Cui; Shuhei Matsuoka; David Cortez; Katsuyuki Tamai; G Luo; S Carattini-Rivera; Francesco DeMayo; Allan Bradley; Lawrence A Donehower; Stephen J Elledge
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.
Genes & development 2000;14(12):1448-59.
2000: Yanchang Wang; David Cortez; P Yazdi; N Neff; Stephen J Elledge; Jun Qin
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Genes & development 2000;14(8):927-39.
2000: Mingxia Huang; Stephen J Elledge
The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway.
Cold Spring Harbor symposia on quantitative biology 2000;65():413-21.
2000: Q Liu; M Z Li; Dan Liu; Stephen J Elledge
Rapid construction of recombinant DNA by the univector plasmid-fusion system.
Methods in enzymology 2000;328():530-49.
1999: Y Sanchez; Jeff Bachant; H Wang; Fenghua Hu; Dan Liu; Michael T Tetzlaff; Stephen J Elledge
Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.
Science (New York, N.Y.) 1999;286(5442):1166-71.
1999: David Cortez; Yanchang Wang; Jun Qin; Stephen J Elledge
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.
Science (New York, N.Y.) 1999;286(5442):1162-6.
1999: JT Winston; Deanna M Koepp; C Zhu; Stephen J Elledge; J Wade Harper
A family of mammalian F-box proteins.
Current biology : CB 1999;9(20):1180-2.
1999: Ilia Ouspenski; Stephen J Elledge; Bill R Brinkley
New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability.
Nucleic acids research 1999;27(15):3001-8.
1999: Katsumi Kitagawa; Dorota Skowyra; Stephen J Elledge; J Wade Harper; Philip Hieter
SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex.
Molecular cell 1999;4(1):21-33.
1999: Deanna M Koepp; J Wade Harper; Stephen J Elledge
How the cyclin became a cyclin: regulated proteolysis in the cell cycle.
Cell 1999;97(4):431-4.
1999: J B Bachant; Stephen J Elledge
Mitotic treasures in the nucleolus.
Nature 1999;398(6730):757-8.
1999: Dorota Skowyra; Deanna M Koepp; Takumi Kamura; Michael N Conrad; Ronald C Conaway; Joan Weliky Conaway; Stephen J Elledge; J Wade Harper
Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.
Science (New York, N.Y.) 1999;284(5414):662-5.
1999: Takumi Kamura; Deanna M Koepp; Michael N Conrad; Dorota Skowyra; Rodney Moreland; O Iliopoulos; William Stratton Lane; William G Kaelin; Stephen J Elledge; Ronald C Conaway; J Wade Harper; Joan Weliky Conaway
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
Science (New York, N.Y.) 1999;284(5414):657-61.
1999: Haibin Wang; Stephen J Elledge
DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3824-9.
1999: JT Winston; Peter Strack; P Beer-Romero; C Y Chu; Stephen J Elledge; J Wade Harper
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.
Genes & development 1999;13(3):270-83.
1999: Pumin Zhang; C Wong; Dou Liu; Milton Finegold; J Wade Harper; Stephen J Elledge
p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step.
Genes & development 1999;13(2):213-24.
1999: E Gómez Lahoz; NANETTE LIEGEOIS; Pumin Zhang; J A Engelman; J Horner; A Silverman; R Burde; M F Roussel; C J Sherr; Stephen J Elledge; Ronald A DePinho
Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo.
Molecular and cellular biology 1999;19(1):353-63.
1998: Shuhei Matsuoka; Mingxia Huang; Stephen J Elledge
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.
Science (New York, N.Y.) 1998;282(5395):1893-7.
1998: Q Liu; M Z Li; D Leibham; D Cortez; Stephen J Elledge
The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes.
Current biology : CB 1998;8(24):1300-9.
1998: B A Desany; Annette A Alcasabas; Jeff Bachant; Stephen J Elledge
Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway.
Genes & development 1998;12(18):2956-70.
1998: Mingxia Huang; Z Zhou; Stephen J Elledge
The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor.
Cell 1998;94(5):595-605.
1998: M C Edwards; C Wong; Stephen J Elledge
Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity.
Molecular and cellular biology 1998;18(7):4291-300.
1998: Stephen J Elledge; J Wade Harper
The role of protein stability in the cell cycle and cancer.
Biochimica et biophysica acta 1998;1377(2):M61-70.
1998: J Wade Harper; Stephen J Elledge
The role of Cdk7 in CAK function, a retro-retrospective.
Genes & development 1998;12(3):285-9.
1998: L Connell-Crowley; Stephen J Elledge; J Wade Harper
G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts.
Current biology : CB 1998;8(1):65-8.
1997: M C Edwards; NANETTE LIEGEOIS; Joe Horecka; Ronald A DePinho; George F Sprague; Mike Tyers; Stephen J Elledge
Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells.
Genetics 1997;147(3):1063-76.
1997: Dorota Skowyra; KL Craig; Mike Tyers; Stephen J Elledge; J Wade Harper
F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.
Cell 1997;91(2):209-19.
1997: Mingxia Huang; Stephen J Elledge
Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae.
Molecular and cellular biology 1997;17(10):6105-13.
1997: Y Sanchez; C Wong; RS Thoma; Ronald Richman; Z Wu; Helen Piwnica-Worms; Stephen J Elledge
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.
Science (New York, N.Y.) 1997;277(5331):1497-501.
1997: Pumin Zhang; NANETTE LIEGEOIS; C Wong; Milton Finegold; Harry Hou; J C Thompson; A Silverman; J Wade Harper; Ronald A DePinho; Stephen J Elledge
Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome.
Nature 1997;387(6629):151-8.
1997: Y Sanchez; Z Zhou; Mingxia Huang; B E Kemp; Stephen J Elledge
Analysis of budding yeast kinases controlled by DNA damage.
Methods in enzymology 1997;283():398-410.
1997: C Bai; Stephen J Elledge
Gene identification using the yeast two-hybrid system.
Methods in enzymology 1997;283():141-56.
1996: Stephen J Elledge
Cell cycle checkpoints: preventing an identity crisis.
Science (New York, N.Y.) 1996;274(5293):1664-72.
1996: T A Navas; Y Sanchez; Stephen J Elledge
RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae.
Genes & development 1996;10(20):2632-43.
1996: Rueyling Lin; C David Allis; Stephen J Elledge
PAT1, an evolutionarily conserved acetyltransferase homologue, is required for multiple steps in the cell cycle.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(10):923-42.
1996: C Bai; P Sen; Kay Hofmann; L Ma; M Goebl; J Wade Harper; Stephen J Elledge
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
Cell 1996;86(2):263-74.
1996: S Matsuoka; J S Thompson; M C Edwards; J M Bartletta; Paul E Grundy; Linda M Kalikin; J Wade Harper; Stephen J Elledge; Andrew P Feinberg
Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):3026-30.
1996: Y Sanchez; B A Desany; W J Jones; Q Liu; Bin Wang; Stephen J Elledge
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.
Science (New York, N.Y.) 1996;271(5247):357-60.
1996: C Bai; Stephen J Elledge
Gene identification using the yeast two-hybrid system.
Methods in enzymology 1996;273():331-47.
1995: Jan M N Hoovers; Linda M Kalikin; L A Johnson; Marielle Alders; B Redeker; David J Law; Jet Bliek; MJ Steenman; M Benedict; Joop Wiegant; Christoph Lengauer; P Taillon-Miller; David Schlessinger; M C Edwards; Stephen J Elledge; Alasdair Ivens; Andries Westerveld; P Little; marcel mannens; Andrew P Feinberg
Multiple genetic loci within 11p15 defined by Beckwith-Wiedemann syndrome rearrangement breakpoints and subchromosomal transferable fragments.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12456-60.
1995: James A Eastham; S J Hall; I Sehgal; Jin Wang; Terry L Timme; Guang Yang; L Connell-Crowley; Stephen J Elledge; W W Zhang; J Wade Harper
In vivo gene therapy with p53 or p21 adenovirus for prostate cancer.
Cancer research 1995;55(22):5151-5.
1995: C Deng; P Zhang; J W Harper; Stephen J Elledge; Philip Leder
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.
Cell 1995;82(4):675-84.
1995: Y Sanchez; Stephen J Elledge
Stopped for repairs.
BioEssays : news and reviews in molecular, cellular and developmental biology 1995;17(6):545-8.
1995: J Wade Harper; Stephen J Elledge; Khandan Keyomarsi; Brian David Dynlacht; Li-Huei Tsai; P Zhang; S Dobrowolski; C Bai; L Connell-Crowley; Eric C Swindell
Inhibition of cyclin-dependent kinases by p21.
Molecular biology of the cell 1995;6(4):387-400.
1995: S Matsuoka; M C Edwards; C Bai; S Parker; Pumin Zhang; A Baldini; J Wade Harper; Stephen J Elledge
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
Genes & development 1995;9(6):650-62.
1995: S B Parker; Gregor Eichele; Pumin Zhang; A Rawls; A T Sands; Allan Bradley; E N Olson; J Wade Harper; Stephen J Elledge
p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells.
Science (New York, N.Y.) 1995;267(5200):1024-7.
1995: T A Navas; Z Zhou; Stephen J Elledge
DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint.
Cell 1995;80(1):29-39.
1994: C Bai; Ronald Richman; Stephen J Elledge
Human cyclin F.
The EMBO journal 1994;13(24):6087-98.
1994: J B Allen; Z Zhou; W Siede; E C Friedberg; Stephen J Elledge
The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.
Genes & development 1994;8(20):2401-15.
1993: J Wade Harper; Guy R Adami; N Wei; Khandan Keyomarsi; Stephen J Elledge
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Cell 1993;75(4):805-16.
1993: Stephen J Elledge; Z Zhou; J B Allen; T A Navas
DNA damage and cell cycle regulation of ribonucleotide reductase.
BioEssays : news and reviews in molecular, cellular and developmental biology 1993;15(5):333-9.
1992: S W Ramer; Stephen J Elledge; Ronald W Davis
Dominant genetics using a yeast genomic library under the control of a strong inducible promoter.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11589-93.
1992: Z Zhou; Stephen J Elledge
Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae.
Genetics 1992;131(4):851-66.
1992: Stephen J Elledge; Ronald Richman; Frederick L Hall; Richard Williams; N Lodgson; J Wade Harper
CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2907-11.
1992: Stephen J Elledge; Z Zhou; J B Allen
Ribonucleotide reductase: regulation, regulation, regulation.
Trends in biochemical sciences 1992;17(3):119-23.
1991: Stephen J Elledge; M R Spottswood
A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.
The EMBO journal 1991;10(9):2653-9.
1991: Stephen J Elledge; John Mulligan; S W Ramer; M Spottswood; Ronald W Davis
Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1731-5.
1990: Stephen J Elledge; Ronald W Davis
Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase.
Genes & development 1990;4(5):740-51.
1990: Maria Jasin; Stephen J Elledge; Ronald W Davis; Paul Berg
Gene targeting at the human CD4 locus by epitope addition.
Genes & development 1990;4(2):157-66.
1989: Stephen J Elledge; Ronald W Davis
Identification of the DNA damage-responsive element of RNR2 and evidence that four distinct cellular factors bind it.
Molecular and cellular biology 1989;9(12):5373-86.
1989: Stephen J Elledge; Ronald W Davis
DNA damage induction of ribonucleotide reductase.
Molecular and cellular biology 1989;9(11):4932-40.
1989: Stephen J Elledge; P Sugiono; L Guarente; Ronald W Davis
Genetic selection for genes encoding sequence-specific DNA-binding proteins.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3689-93.
1989: Stephen J Elledge; Ronald W Davis
Position and density effects on repression by stationary and mobile DNA-binding proteins.
Genes & development 1989;3(2):185-97.
1987: Stephen J Elledge; Ronald W Davis
Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability.
Molecular and cellular biology 1987;7(8):2783-93.