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Trond Ellingsen

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Molecular Sequence Data

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Anne Krog; Christiane E Kupper; Jonas E N Müller; Olha Schneider; Julia A Vorholt; Trond E Ellingsen; Tonje M B Heggeset; Trygve Brautaset
Methylotrophic Bacillus methanolicus encodes two chromosomal and one plasmid born NAD+ dependent methanol dehydrogenase paralogs with different catalytic and biochemical properties.
Sven E F Borgos; Per Bruheim; Trond E Ellingsen; Helga Ertesvåg; Oyvind Jakobsen; Jens Nielsen; Håvard Sletta; Sergio Bordel; Svein Valla
Mapping global effects of the anti-sigma factor MucA in Pseudomonas fluorescens SBW25 through genome-scale metabolic modeling.
Tonje M B Heggeset; Anne Krog; Alexander Wentzel; Simone Balzer; Trond E Ellingsen; Trygve Brautaset
Genome sequence of thermotolerant Bacillus methanolicus: features and regulation related to methylotrophy and production of L-lysine and L-glutamate from methanol.

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All Publications

2013: Anne Krog; Christiane E Kupper; Jonas E N Müller; Olha Schneider; Julia A Vorholt; Trond E Ellingsen; Tonje M B Heggeset; Trygve Brautaset
Methylotrophic Bacillus methanolicus encodes two chromosomal and one plasmid born NAD+ dependent methanol dehydrogenase paralogs with different catalytic and biochemical properties.
PloS one 2013;8(3):e59188.
2013: Sven E F Borgos; Per Bruheim; Trond E Ellingsen; Helga Ertesvåg; Oyvind Jakobsen; Jens Nielsen; Håvard Sletta; Sergio Bordel; Svein Valla
Mapping global effects of the anti-sigma factor MucA in Pseudomonas fluorescens SBW25 through genome-scale metabolic modeling.
BMC systems biology 2013;7():19.
2012: Tonje M B Heggeset; Anne Krog; Alexander Wentzel; Simone Balzer; Trond E Ellingsen; Trygve Brautaset
Genome sequence of thermotolerant Bacillus methanolicus: features and regulation related to methylotrophy and production of L-lysine and L-glutamate from methanol.
Applied and environmental microbiology 2012;78(15):5170-81.
2012: Juan F Martín; Kay Nieselt; Antonio Rodríguez-García; Fernando Santos-Beneit; Margaret C M Smith; Alberto Sola-Landa; Nigel J Burroughs; Trond E Ellingsen; Elizabeth M H Wellington
Transcriptomic studies of phosphate control of primary and secondary metabolism in Streptomyces coelicolor.
Applied microbiology and biotechnology 2012;95(1):61-75.
2012: Elon Correa; Trond E Ellingsen; David I Ellis; Helga Ertesvåg; Sunniva Hoel; Håvard Sletta; Svein Valla; Royston Goodacre
Rapid reagentless quantification of alginate biosynthesis in Pseudomonas fluorescens bacteria mutants using FT-IR spectroscopy coupled to multivariate partial least squares regression.
Analytical and bioanalytical chemistry 2012;403(9):2591-9.
2012: Louise Thomas; Elizabeth M H Wellington; Alexander Wentzel; Wolfgang Wohlleben; Nigel J Burroughs; Trond E Ellingsen; David A Hodgson; Roxane Legaie; Juan F Martín; Jonathan Moore; Edward R Morrissey; Kay Nieselt; Antonio Rodríguez-García; Margaret C M Smith
Metabolic switches and adaptations deduced from the proteomes of Streptomyces coelicolor wild type and phoP mutant grown in batch culture.
Molecular & cellular proteomics : MCP 2012;11(2):M111.013797.
2012: Anne Tøndervik; Svein Valla; Laila Berg; Per Bruheim; Trond E Ellingsen; Hans-Kristian Kotlar; Mimmi Throne-Holst
Ralstonia sp. U2 naphthalene dioxygenase and Comamonas sp. JS765 nitrobenzene dioxygenase show differences in activity towards methylated naphthalenes.
Journal of bioscience and bioengineering 2012;113(2):173-8.
2012: Alexander Wentzel; Øyvind M Jakobsen; Anders Øverby; Per Bruheim; David A Hodgson; Walid A M Omara; Håvard Sletta; Trond E Ellingsen
Optimized submerged batch fermentation strategy for systems scale studies of metabolic switching in Streptomyces coelicolor A3(2).
BMC systems biology 2012;6():59.
2011: Eva Waldvogel; Alexander Wentzel; Wolfgang Wohlleben; Merle Nentwich; Kay Nieselt; Rafat Amin; Florian Battke; Trond E Ellingsen; Alexander Herbig; David A Hodgson; Yvonne Mast
The PII protein GlnK is a pleiotropic regulator for morphological differentiation and secondary metabolism in Streptomyces coelicolor.
Applied microbiology and biotechnology 2011;92(6):1219-36.
2011: Sondre Heia; Francisco Malpartida; Elena M Seco; Håvard Sletta; Sven E F Borgos; Trond E Ellingsen; Leticia Escudero; Sergey B Zotchev
Initiation of polyene macrolide biosynthesis: interplay between polyketide synthase domains and modules as revealed via domain swapping, mutagenesis, and heterologous complementation.
Applied and environmental microbiology 2011;77(19):6982-90.
2011: Trygve Brautaset; Kristin F Degnes; Trond E Ellingsen; Olga N Sekurova; Håvard Sletta; Olga Volokhan; Trygve Andreassen; Ingrid Bakke; Sergey B Zotchev
New nystatin-related antifungal polyene macrolides with altered polyol region generated via biosynthetic engineering of Streptomyces noursei.
Applied and environmental microbiology 2011;77(18):6636-43.
2011: Ingemar Nærdal; Roman Netzer; Trond E Ellingsen; Trygve Brautaset
Analysis and manipulation of aspartate pathway genes for L-lysine overproduction from methanol by Bacillus methanolicus.
Applied and environmental microbiology 2011;77(17):6020-6.
2010: Anne Tøndervik; Geir Klinkenberg; Olav A Aarstad; Finn Drabløs; Helga Ertesvåg; Trond E Ellingsen; Gudmund Skjåk-Braek; Svein Valla; Håvard Sletta
Isolation of mutant alginate lyases with cleavage specificity for di-guluronic acid linkages.
The Journal of biological chemistry 2010;285(46):35284-92.
2010: Kerstin Engelhardt; Kristin F Degnes; Michael Kemmler; Harald Bredholt; Espen Fjaervik; Geir Klinkenberg; Håvard Sletta; Trond E Ellingsen; Sergey B Zotchev
Production of a new thiopeptide antibiotic, TP-1161, by a marine Nocardiopsis species.
Applied and environmental microbiology 2010;76(15):4969-76.
2010: Trygve Brautaset; Øyvind M Jakobsen; Kristin F Degnes; Roman Netzer; Ingemar Naerdal; Anne Krog; Rick Dillingham; Michael C Flickinger; Trond E Ellingsen
Bacillus methanolicus pyruvate carboxylase and homoserine dehydrogenase I and II and their roles for L-lysine production from methanol at 50 degrees C.
Applied microbiology and biotechnology 2010;87(3):951-64.
2010: Marit H Stafsnes; Kjell D Josefsen; Geir Kildahl-Andersen; Svein Valla; Trond E Ellingsen; Per Bruheim
Isolation and characterization of marine pigmented bacteria from Norwegian coastal waters and screening for carotenoids with UVA-blue light absorbing properties.
Journal of microbiology (Seoul, Korea) 2010;48(1):16-23.
2009: Hanne Jørgensen; Kristin F Degnes; Håvard Sletta; Espen Fjaervik; Alexander Dikiy; Lars Herfindal; Per Bruheim; Geir Klinkenberg; Harald Bredholt; Gyrid Nygård; Stein O Døskeland; Trond E Ellingsen; Sergey B Zotchev
Biosynthesis of macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit.
Chemistry & biology 2009;16(10):1109-21.
2009: Trine Aakvik; Kristin Fløgstad Degnes; Rannveig Dahlsrud; Frank Schmidt; Ragnar Dam; Lihua Yu; Uwe Völker; Trond E Ellingsen; Svein Valla
A plasmid RK2-based broad-host-range cloning vector useful for transfer of metagenomic libraries to a variety of bacterial species.
FEMS microbiology letters 2009;296(2):149-58.
2009: Hanne Jørgensen; Espen Fjaervik; Sigrid Hakvåg; Per Bruheim; Harald Bredholt; Geir Klinkenberg; Trond E Ellingsen; Sergey B Zotchev
Candicidin biosynthesis gene cluster is widely distributed among Streptomyces spp. isolated from the sediments and the neuston layer of the Trondheim fjord, Norway.
Applied and environmental microbiology 2009;75(10):3296-303.
2009: Oyvind M Jakobsen; Trygve Brautaset; Kristin F Degnes; Tonje M B Heggeset; Simone Balzer; Michael C Flickinger; Svein Valla; Trond E Ellingsen
Overexpression of wild-type aspartokinase increases L-lysine production in the thermotolerant methylotrophic bacterium Bacillus methanolicus.
Applied and environmental microbiology 2009;75(3):652-61.
2009: Sigrid Hakvåg; Espen Fjaervik; Geir Klinkenberg; Sven Even F Borgos; Kjell D Josefsen; Trond E Ellingsen; Sergey B Zotchev
Violacein-producing Collimonas sp. from the sea surface microlayer of costal waters in Trøndelag, Norway.
Marine drugs 2009;7(4):576-88.
2008: Trygve Brautaset; Håvard Sletta; Aina Nedal; Sven E F Borgos; Kristin F Degnes; Ingrid Bakke; Olga Volokhan; Olga N Sekurova; Ivan D Treshalin; Elena P Mirchink; Alexander Dikiy; Trond E Ellingsen; Sergey B Zotchev
Improved antifungal polyene macrolides via engineering of the nystatin biosynthetic genes in Streptomyces noursei.
Chemistry & biology 2008;15(11):1198-206.
2008: Steigedal Magnus; Håvard Sletta; Soledad Moreno; Mali Maerk; Bjørn E Christensen; Tonje Bjerkan; Trond E Ellingsen; Guadalupe Espìn; Helga Ertesvåg; Svein Valla
The Azotobacter vinelandii AlgE mannuronan C-5-epimerase family is essential for the in vivo control of alginate monomer composition and for functional cyst formation.
Environmental microbiology 2008;10(7):1760-70.
2008: Sigrid Hakvåg; Espen Fjaervik; Kjell D Josefsen; Elena Ian; Trond E Ellingsen; Sergey B Zotchev
Characterization of Streptomyces spp. isolated from the sea surface microlayer in the Trondheim Fjord, Norway.
Marine drugs 2008;6(4):620-35.
2007: Aina Nedal; Håvard Sletta; Trygve Brautaset; Sven E F Borgos; Olga N Sekurova; Trond E Ellingsen; Sergey B Zotchev
Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455.
Applied and environmental microbiology 2007;73(22):7400-7.
2007: Alexander Wentzel; Trond E Ellingsen; Hans-Kristian Kotlar; Sergey B Zotchev; Mimmi Throne-Holst
Bacterial metabolism of long-chain n-alkanes.
Applied microbiology and biotechnology 2007;76(6):1209-21.
2007: Mimmi Throne-Holst; Alexander Wentzel; Trond E Ellingsen; Hans-Kristian Kotlar; Sergey B Zotchev
Identification of novel genes involved in long-chain n-alkane degradation by Acinetobacter sp. strain DSM 17874.
Applied and environmental microbiology 2007;73(10):3327-32.
2007: Trygve Brautaset; Øyvind M Jakobsen; Kjell D Josefsen; Michael C Flickinger; Trond E Ellingsen
Bacillus methanolicus: a candidate for industrial production of amino acids from methanol at 50 degrees C.
Applied microbiology and biotechnology 2007;74(1):22-34.
2007: Håvard Sletta; A Tøndervik; S Hakvåg; T E Vee Aune; Aina Nedal; Randi Aune; G Evensen; Svein Valla; Trond E Ellingsen; Trygve Brautaset
The presence of N-terminal secretion signal sequences leads to strong stimulation of the total expression levels of three tested medically important proteins during high-cell-density cultivations of Escherichia coli.
Applied and environmental microbiology 2007;73(3):906-12.
2006: Mimmi Throne-Holst; Sidsel Markussen; Asgeir Winnberg; Trond E Ellingsen; Hans-Kristian Kotlar; Sergey B Zotchev
Utilization of n-alkanes by a newly isolated strain of Acinetobacter venetianus: the role of two AlkB-type alkane hydroxylases.
Applied microbiology and biotechnology 2006;72(2):353-60.
2006: Sven E F Borgos; Pascale Tsan; Håvard Sletta; Trond E Ellingsen; Jean-Marc Lancelin; Sergey B Zotchev
Probing the structure-function relationship of polyene macrolides: engineered biosynthesis of soluble nystatin analogues.
Journal of medicinal chemistry 2006;49(8):2431-9.
2006: Olga Volokhan; Håvard Sletta; Trond E Ellingsen; Sergey B Zotchev
Characterization of the P450 monooxygenase NysL, responsible for C-10 hydroxylation during biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei.
Applied and environmental microbiology 2006;72(4):2514-9.
2006: Øyvind M Jakobsen; Aline Benichou; Michael C Flickinger; Svein Valla; Trond E Ellingsen; Trygve Brautaset
Upregulated transcription of plasmid and chromosomal ribulose monophosphate pathway genes is critical for methanol assimilation rate and methanol tolerance in the methylotrophic bacterium Bacillus methanolicus.
Journal of bacteriology 2006;188(8):3063-72.
2006: Sven E F Borgos; Håvard Sletta; Espen Fjaervik; Trygve Brautaset; Trond E Ellingsen; Ole-Martin Gulliksen; Sergey B Zotchev
Effect of glucose limitation and specific mutations in the module 5 enoyl reductase domains in the nystatin and amphotericin polyketide synthases on polyene macrolide biosynthesis.
Archives of microbiology 2006;185(3):165-71.
2005: Karianne Bakkevig; Håvard Sletta; Martin Gimmestad; Randi Aune; Helga Ertesvåg; Kristin Degnes; Bjørn E Christensen; Trond E Ellingsen; Svein Valla
Role of the Pseudomonas fluorescens alginate lyase (AlgL) in clearing the periplasm of alginates not exported to the extracellular environment.
Journal of bacteriology 2005;187(24):8375-84.
2005: Håvard Sletta; Sven E F Borgos; Per Bruheim; Olga N Sekurova; Hans Grasdalen; Randi Aune; Trond E Ellingsen; Sergey B Zotchev
Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin.
Antimicrobial agents and chemotherapy 2005;49(11):4576-83.
2005: Olga Volokhan; Håvard Sletta; Olga N Sekurova; Trond E Ellingsen; Sergey B Zotchev
An unexpected role for the putative 4'-phosphopantetheinyl transferase-encoding gene nysF in the regulation of nystatin biosynthesis in Streptomyces noursei ATCC 11455.
FEMS microbiology letters 2005;249(1):57-64.
2005: I D Treshchalin; Håvard Sletta; Sven E F Borgos; E P Pereverzeva; T A Voeĭkova; Trond E Ellingsen; Sergey B Zotchev
[Comparative analysis of in vitro antifungal activity and in vivo acute toxicity of the nystatin analogue S44HP produced via genetic engineering].
Antibiotiki i khimioterapii͡a = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoĭ i mikrobiologicheskoĭ promyshlennosti SSSR 2005;50(7):18-22.
2004: Håvard Sletta; Aina Nedal; T E V Aune; H Hellebust; S Hakvåg; Randi Aune; Trond E Ellingsen; Svein Valla; Trygve Brautaset
Broad-host-range plasmid pJB658 can be used for industrial-level production of a secreted host-toxic single-chain antibody fragment in Escherichia coli.
Applied and environmental microbiology 2004;70(12):7033-9.
2004: Per Bruheim; Sven E F Borgos; Pascale Tsan; Håvard Sletta; Trond E Ellingsen; Jean-Marc Lancelin; Sergey B Zotchev
Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.
Antimicrobial agents and chemotherapy 2004;48(11):4120-9.
2004: Trygve Brautaset; Øyvind M Jakobsen M; Michael C Flickinger; Svein Valla; Trond E Ellingsen
Plasmid-dependent methylotrophy in thermotolerant Bacillus methanolicus.
Journal of bacteriology 2004;186(5):1229-38.
2004: Olga N Sekurova; Trygve Brautaset; Håvard Sletta; Sven E F Borgos; Øyvind M Jakobsen M; Trond E Ellingsen; Arne R Strøm; Svein Valla; Sergey B Zotchev
In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis.
Journal of bacteriology 2004;186(5):1345-54.
2003: Martin Gimmestad; Håvard Sletta; Helga Ertesvåg; Karianne Bakkevig; Sumita Jain; Sang-Jin Suh; Gudmund Skjåk-Braek; Trond E Ellingsen; Dennis Ohman; Svein Valla
The Pseudomonas fluorescens AlgG protein, but not its mannuronan C-5-epimerase activity, is needed for alginate polymer formation.
Journal of bacteriology 2003;185(12):3515-23.
2003: Trygve Brautaset; Sven E F Borgos; Håvard Sletta; Trond E Ellingsen; Sergey B Zotchev
Site-specific mutagenesis and domain substitutions in the loading module of the nystatin polyketide synthase, and their effects on nystatin biosynthesis in Streptomyces noursei.
The Journal of biological chemistry 2003;278(17):14913-9.
2002: Per Bruheim; M Butler; Trond E Ellingsen
A theoretical analysis of the biosynthesis of actinorhodin in a hyper-producing Streptomyces lividansstrain cultivated on various carbon sources.
Applied microbiology and biotechnology 2002;58(6):735-42.
2002: Trygve Brautaset; Per Bruheim; Håvard Sletta; Lars Hagen; Trond E Ellingsen; Arne R Strøm; Svein Valla; Sergey B Zotchev
Hexaene derivatives of nystatin produced as a result of an induced rearrangement within the nysC polyketide synthase gene in S. noursei ATCC 11455.
Chemistry & biology 2002;9(3):367-73.
2000: Trygve Brautaset; Olga N Sekurova; Håvard Sletta; Trond E Ellingsen; A R StrŁm; Svein Valla; Sergey B Zotchev
Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.
Chemistry & biology 2000;7(6):395-403.
2000: Sergey B Zotchev; K Haugan; Olga N Sekurova; Håvard Sletta; Trond E Ellingsen; Svein Valla
Identification of a gene cluster for antibacterial polyketide-derived antibiotic biosynthesis in the nystatin producer Streptomyces noursei ATCC 11455.
Microbiology (Reading, England) 2000;146 ( Pt 3)():611-9.
1999: Olga N Sekurova; Håvard Sletta; Trond E Ellingsen; Svein Valla; Sergey B Zotchev
Molecular cloning and analysis of a pleiotropic regulatory gene locus from the nystatin producer Streptomyces noursei ATCC11455.
FEMS microbiology letters 1999;177(2):297-304.