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John Elliott

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Guanghui Deng; John D Elliott; Taylor B Guo; Qian Liu; Hongtao Lu; Qinghua Meng; Feng Ren; Jia-Ning Xiang; Qiongfeng Xu; Xuesong Xu; Xichen Lin
Identification of benzoxazole analogs as novel, S1P(3) sparing S1P(1) agonists.
Feng Ren; Hailong Wang; Jia-Ning Xiang; Heng Xu; Qiongfeng Xu; Xuesong Xu; Jiansong Yang; Haibo Zhang; Wei Zhang; Baowei Zhao; Yonggang Zhao; Guanghui Deng; John D Elliott; Taylor B Guo; Qiantao Jia; Chengyong Li; Hongtao Lu; Linbo Luan; Qinghua Meng; Xichen Lin
Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)).
Qinghua Meng; Feng Ren; Hailong Wang; Jia-Ning Xiang; Heng Xu; Qiongfeng Xu; Xuesong Xu; Yan Xu; Haibo Zhang; Wei Zhang; Baowei Zhao; Yonggang Zhao; Guanghui Deng; John D Elliott; Taylor B Guo; Chengyong Li; Hongtao Lu; Linbo Luan; Xichen Lin
Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists.

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2012: Guanghui Deng; John D Elliott; Taylor B Guo; Qian Liu; Hongtao Lu; Qinghua Meng; Feng Ren; Jia-Ning Xiang; Qiongfeng Xu; Xuesong Xu; Xichen Lin
Identification of benzoxazole analogs as novel, S1P(3) sparing S1P(1) agonists.
Bioorganic & medicinal chemistry letters 2012;22(12):3973-7.
2012: Feng Ren; Hailong Wang; Jia-Ning Xiang; Heng Xu; Qiongfeng Xu; Xuesong Xu; Jiansong Yang; Haibo Zhang; Wei Zhang; Baowei Zhao; Yonggang Zhao; Guanghui Deng; John D Elliott; Taylor B Guo; Qiantao Jia; Chengyong Li; Hongtao Lu; Linbo Luan; Qinghua Meng; Xichen Lin
Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)).
Journal of medicinal chemistry 2012;55(9):4286-96.
2012: Qinghua Meng; Feng Ren; Hailong Wang; Jia-Ning Xiang; Heng Xu; Qiongfeng Xu; Xuesong Xu; Yan Xu; Haibo Zhang; Wei Zhang; Baowei Zhao; Yonggang Zhao; Guanghui Deng; John D Elliott; Taylor B Guo; Chengyong Li; Hongtao Lu; Linbo Luan; Xichen Lin
Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists.
Bioorganic & medicinal chemistry letters 2012;22(8):2794-7.
2012: Heng Xu; Yan Xu; Ting Yang; Haibo Zhang; Wei Zhang; Yonggang Zhao; John D Elliott; Taylor B Guo; Fangbin Han; David Hirst; Chengyong Li; Matthew Lindon; Hongtao Lu; Linbo Luan; Feng Ren; Yonghui Wang; Jia-Ning Xiang; Xichen Lin
Discovery of thiadiazole amides as potent, S1P₃-sparing agonists of sphingosine-1-phosphate 1 (S1P₁) receptor.
Bioorganic & medicinal chemistry letters 2012;22(7):2456-9.
2011: Zehong Wan; Jian Wang; Jia-Ning Xiang; Eric Yang; Guang Yang; Haihua Yu; Xiaomin Zhang; Wei Zhao; Yanjiao Zhou; Ziqiang Cheng; John D Elliott; Adrian Hall; David C Harrison; Julie Hawkins; Ishrut Hussain; Yun Jin; Matthew R Johnson; Lit-Fui Lau; Tina Li; William L Mitchell; Helen S Price; Yingxia Sang; Beverley Smith; Xiaobo Su; Zhaolong Tong; Yasuji Matsuoka
Pyridine-derived γ-secretase modulators.
Bioorganic & medicinal chemistry letters 2011;21(16):4832-5.
2006: Hong Nie; Katherine L Widdowson; Michael R Palovich; Wei Fu; John D Elliott; Deborah L Bryan; Miriam Burman; Dulcie B Schmidt; James J Foley; Henry M Sarau; Jakob Busch-Petersen
N,N'-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors.
Bioorganic & medicinal chemistry letters 2006;16(21):5513-6.
2006: Eliot ohlstein; Anthony G Johnson; John D Elliott; Anne M Romanic
New strategies in drug discovery.
Methods in molecular biology (Clifton, N.J.) 2006;316():1-11.
2004: Qi Jin; Hong Nie; Brent W McCleland; Katherine L Widdowson; Michael R Palovich; John D Elliott; Richard M Goodman; Miriam Burman; Henry M Sarau; Keith W Ward; Melanie Nord; Bonnie M Orr; Peter D Gorycki; Jakob Busch-Petersen
Discovery of potent and orally bioavailable N,N'-diarylurea antagonists for the CXCR2 chemokine receptor.
Bioorganic & medicinal chemistry letters 2004;14(17):4375-8.
2004: Katherine L Widdowson; John D Elliott; Daniel F Veber; Hong Nie; Melvin C Rutledge; Brent W McCleland; Jia-Ning Xiang; Anthony Jurewicz; Robert P Hertzberg; James J Foley; Don E Griswold; Lenox Martin; Judithann M Lee; John White; Henry M Sarau
Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor.
Journal of medicinal chemistry 2004;47(6):1319-21.
2000: Eliot ohlstein; RR Ruffolo; John D Elliott
Drug discovery in the next millennium.
Annual review of pharmacology and toxicology 2000;40():177-91.
1999: David C Underwood; S Bochnowicz; RR Osborn; Mark A Luttmann; CS Louden; Timothy K Hart; John D Elliott; Douglas W P Hay
Effect of SB 217242 on hypoxia-induced cardiopulmonary changes in the high altitude-sensitive rat.
Pulmonary pharmacology & therapeutics 1999;12(1):13-26.
1999: P Raval; S Bingham; N Aiyar; John D Elliott; A Jackie Hunter; Eliot ohlstein; Andrew A Parsons
Trigeminal nerve ganglion stimulation-induced neurovascular reflexes in the anaesthetized cat: role of endothelin(B) receptors in carotid vasodilatation.
British journal of pharmacology 1999;126(2):485-93.
1998: Eliot ohlstein; Ponnal Nambi; Douglas W P Hay; M Gellai; David P Brooks; JI Luengo; Jia-Ning Xiang; John D Elliott
Nonpeptide endothelin receptor antagonists. XI. Pharmacological characterization of SB 234551, a high-affinity and selective nonpeptide ETA receptor antagonist.
The Journal of pharmacology and experimental therapeutics 1998;286(2):650-6.
1998: Jia-Ning Xiang; Ponnal Nambi; Eliot ohlstein; John D Elliott
An efficient approach to the synthesis of 1,3-diaryl-1,2,3,4-[4H]-tetrahydronaphthalene-2-carboxylic acids.
Bioorganic & medicinal chemistry 1998;6(6):695-700.
1998: John D Elliott; Eliot ohlstein; CE Peishoff; H M Ellens; MA Lago
Endothelin receptor antagonists.
Pharmaceutical biotechnology 1998;11():113-29.
1998: David P Brooks; PD Depalma; Mark A Pullen; John D Elliott; Eliot ohlstein; Ponnal Nambi
SB 234551, a novel endothelin--A receptor antagonist, unmasks endothelin-induced renal vasodilatation in the dog.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S339-41.
1998: Stephen Douglas; Ponnal Nambi; M Gellai; JI Luengo; Jia-Ning Xiang; David P Brooks; RR Ruffolo; John D Elliott; Eliot ohlstein
Pharmacologic characterization of the novel, orally available endothelin-A--selective antagonist SB 247083.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S273-6.
1998: Robert N Willette; Charles F Sauermelch; B L Storer; S Guiney; JI Luengo; Jia-Ning Xiang; John D Elliott; Eliot ohlstein
Plasma- and cerebrospinal fluid-immunoreactive endothelin-1: effects of nonpeptide endothelin receptor antagonists with diverse affinity profiles for endothelin-A and endothelin-B receptors.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S149-57.
1998: Stephen Douglas; A J Nichols; Giora Z Feuerstein; John D Elliott; Eliot ohlstein
SB 209670 inhibits the arrhythmogenic actions of endothelin-1 in the anesthetized dog.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S99-102.
1996: Eliot ohlstein; Ponnal Nambi; A Lago; Douglas W P Hay; G Beck; K L Fong; E P Eddy; P Smith; H Ellens; John D Elliott
Nonpeptide endothelin receptor antagonists. VI: Pharmacological characterization of SB 217242, a potent and highly bioavailable endothelin receptor antagonist.
The Journal of pharmacology and experimental therapeutics 1996;276(2):609-15.
1995: M Gellai; M Jugus; T Fletcher; Ponnal Nambi; Eliot ohlstein; John D Elliott; David P Brooks
Nonpeptide endothelin receptor antagonists. V: Prevention and reversal of acute renal failure in the rat by SB 209670.
The Journal of pharmacology and experimental therapeutics 1995;275(1):200-6.
1995: Stephen Douglas; M Gellai; M Ezekiel; Giora Z Feuerstein; John D Elliott; Eliot ohlstein
Antihypertensive actions of the novel nonpeptide endothelin receptor antagonist SB 209670.
Hypertension 1995;25(4 Pt 2):818-22.
1995: Stephen Douglas; G R Beck; John D Elliott; Eliot ohlstein
Pharmacological evidence for the presence of three distinct functional endothelin receptor subtypes in the rabbit lateral saphenous vein.
British journal of pharmacology 1995;114(8):1529-40.
1995: F C Barone; R F White; John D Elliott; Giora Z Feuerstein; Eliot ohlstein
The endothelin receptor antagonist SB 217242 reduces cerebral focal ischemic brain injury.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S404-7.
1995: G R Beck; Stephen Douglas; John D Elliott; Eliot ohlstein
Agonist-dependent inhibition by peptide and nonpeptide endothelin receptor antagonists in the rabbit isolated pulmonary artery.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S385-8.
1995: Stephen Douglas; L M Vickery-Clark; CS Louden; John D Elliott; Eliot ohlstein
Endothelin receptor subtypes in the pathogenesis of angioplasty-induced neointima formation in the rat: a comparison of selective ETA receptor antagonism and dual ETA/ETB receptor antagonism using BQ-123 and SB 209670.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S186-9.
1995: Stephen Douglas; G R Beck; John D Elliott; Eliot ohlstein
Pharmacologic evidence for the presence of three functional endothelin receptor subtypes in rabbit saphenous vein.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S163-8.
1995: Stephen Douglas; R M Edwards; John D Elliott; Eliot ohlstein
In vivo pharmacological characterization of the non-peptide endothelin receptor antagonist SB 209670.
British journal of pharmacology 1995;114(2):405-13.
1994: David P Brooks; P D dePalma; M Gellai; Ponnal Nambi; Eliot ohlstein; John D Elliott; J G Gleason; RR Ruffolo
Nonpeptide endothelin receptor antagonists. III. Effect of SB 209670 and BQ123 on acute renal failure in anesthetized dogs.
The Journal of pharmacology and experimental therapeutics 1994;271(2):769-75.
1994: Eliot ohlstein; G R Beck; Stephen Douglas; Ponnal Nambi; MA Lago; J G Gleason; RR Ruffolo; Giora Feuerstein; John D Elliott
Nonpeptide endothelin receptor antagonists. II. Pharmacological characterization of SB 209670.
The Journal of pharmacology and experimental therapeutics 1994;271(2):762-8.
1994: Ponnal Nambi; Nabil A Elshourbagy; HL Wu; Mark A Pullen; Eliot ohlstein; David P Brooks; MA Lago; John D Elliott; J G Gleason; RR Ruffolo
Nonpeptide endothelin receptor antagonists. I. Effects on binding and signal transduction on human endothelinA and endothelinB receptors.
The Journal of pharmacology and experimental therapeutics 1994;271(2):755-61.
1994: J A Lee; John D Elliott; J A Sutiphong; W J Friesen; Eliot ohlstein; JM Stadel; J G Gleason; C E Peishoff
Tyr-129 is important to the peptide ligand affinity and selectivity of human endothelin type A receptor.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7164-8.
1994: Stephen Douglas; CS Louden; L M Vickery-Clark; B L Storer; T Hart; Giora Z Feuerstein; John D Elliott; Eliot ohlstein
A role for endogenous endothelin-1 in neointimal formation after rat carotid artery balloon angioplasty. Protective effects of the novel nonpeptide endothelin receptor antagonist SB 209670.
Circulation research 1994;75(1):190-7.
1994: John D Elliott; MA Lago; Russell D Cousins; A Gao; J D Leber; Karl F Erhard; Ponnal Nambi; Nabil A Elshourbagy; C Kumar; J A Lee
1,3-Diarylindan-2-carboxylic acids, potent and selective non-peptide endothelin receptor antagonists.
Journal of medicinal chemistry 1994;37(11):1553-7.
1994: FE Ali; D B Bennett; Raul Calvo; John D Elliott; Shing-Mei Hwang; Thomas W Ku; MA Lago; A J Nichols; T T Romoff; D H Shah
Conformationally constrained peptides and semipeptides derived from RGD as potent inhibitors of the platelet fibrinogen receptor and platelet aggregation.
Journal of medicinal chemistry 1994;37(6):769-80.
1992: Stephen Douglas; John D Elliott; Eliot ohlstein
Regional vasodilation to endothelin-1 is mediated by a non-ETA receptor subtype in the anaesthetized rat: effect of BQ-123 on systemic haemodynamic responses.
European journal of pharmacology 1992;221(2-3):315-24.
1992: Eliot ohlstein; Anthony Arleth; H Bryan; John D Elliott; C P Sung
The selective endothelin ETA receptor antagonist BQ123 antagonizes endothelin-1-mediated mitogenesis.
European journal of pharmacology 1992;225(4):347-50.
1990: R J Mayer; P Louis-Flamberg; John D Elliott; M Fisher; J Leber
Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A synthase by antibiotic 1233A and other beta-lactones.
Biochemical and biophysical research communications 1990;169(2):610-6.
1990: P Louis-Flamberg; C E Peishoff; D L Bryan; J Leber; John D Elliott; B W Metcalf; R J Mayer
Slow binding inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Biochemistry 1990;29(17):4115-20.