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Jonathan Ellman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
27
Bergman, Robert
8
Craik, Charles
7
Maly, Dustin
6
Salisbury, Cleo
6
Souers, Andrew
6
patterson, andrew
5
Tang, Tony
5
Thalji, Reema
5
Peltier, Hillary
5
Huang, Lily
5
Lewis, Jared
5
Harris, Jennifer
5
Backes, Bradley
4
Ahrendt, Kateri
4
Kuntz, Irwin

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Publications

TOP 3
Rawls Katherine A; Lang P Therese; Takeuchi Jun; Imamura Shinichi; Baguley Tyler D; Grundner Christoph; Alber Tom; Ellman Jonathan A
Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.
Tsai Andy S; Wilson Rebecca M; Harada Hitoshi; Bergman Robert G; Ellman Jonathan A
Rhodium catalyzed enantioselective cyclization of substituted imidazoles via C-H bond activation.
Kimmel Kyle L; Robak MaryAnn T; Ellman Jonathan A
Enantioselective addition of thioacetic acid to nitroalkenes via N-sulfinyl urea organocatalysis.

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All Publications

2009: Rawls Katherine A; Lang P Therese; Takeuchi Jun; Imamura Shinichi; Baguley Tyler D; Grundner Christoph; Alber Tom; Ellman Jonathan A
Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.
Bioorganic & medicinal chemistry letters 2009;19(24):6851-4.
2009: Tsai Andy S; Wilson Rebecca M; Harada Hitoshi; Bergman Robert G; Ellman Jonathan A
Rhodium catalyzed enantioselective cyclization of substituted imidazoles via C-H bond activation.
Chemical communications (Cambridge, England) 2009;(26):3910-2.
2009: Kimmel Kyle L; Robak MaryAnn T; Ellman Jonathan A
Enantioselective addition of thioacetic acid to nitroalkenes via N-sulfinyl urea organocatalysis.
Journal of the American Chemical Society 2009;131(25):8754-5.
2009: Arceo Elena; Marsden Peter; Bergman Robert G; Ellman Jonathan A
An efficient didehydroxylation method for the biomass-derived polyols glycerol and erythritol. Mechanistic studies of a formic acid-mediated deoxygenation.
Chemical communications (Cambridge, England) 2009;(23):3357-9.
2009: Brak Katrien; Barrett Kimberly T; Ellman Jonathan A
General one-pot method for the preparation of N-tert-butanesulfinylamine diastereomer mixtures as standards for stereoselectivity determinations.
The Journal of organic chemistry 2009;74(9):3606-8.
2009: Wakayama Masakazu; Ellman Jonathan A
Recycling the tert-butanesulfinyl group in the synthesis of amines using tert-butanesulfinamide.
The Journal of organic chemistry 2009;74(7):2646-50.
2009: Yotphan Sirilata; Bergman Robert G; Ellman Jonathan A
Application of Daugulis copper-catalyzed direct arylation to the synthesis of 5-aryl benzotriazepines.
Organic letters 2009;11(7):1511-4.
2009: Brak Katrien; Ellman Jonathan A
Asymmetric synthesis of alpha-branched allylic amines by the Rh(I)-catalyzed addition of alkenyltrifluoroborates to N-tert-butanesulfinyl aldimines.
Journal of the American Chemical Society 2009;131(11):3850-1.
2008: Harada Hitoshi; Thalji Reema K; Bergman Robert G; Ellman Jonathan A
Enantioselective intramolecular hydroarylation of alkenes via directed C-H bond activation.
The Journal of organic chemistry 2008;73(17):6772-9.
2008: Beenen Melissa A; An Chihui; Ellman Jonathan A
Asymmetric copper-catalyzed synthesis of alpha-amino boronate esters from N-tert-butanesulfinyl aldimines.
Journal of the American Chemical Society 2008;130(22):6910-1.
2008: Tsai Andy S; Bergman Robert G; Ellman Jonathan A
Asymmetric synthesis of (-)-incarvillateine employing an intramolecular alkylation via Rh-catalyzed olefinic C-H bond activation.
Journal of the American Chemical Society 2008;130(20):6316-7.
2008: Brak Katrien; Doyle Patricia S; McKerrow James H; Ellman Jonathan A
Identification of a new class of nonpeptidic inhibitors of cruzain.
Journal of the American Chemical Society 2008;130(20):6404-10.
2008: Colby Denise A; Bergman Robert G; Ellman Jonathan A
Synthesis of dihydropyridines and pyridines from imines and alkynes via C-H activation.
Journal of the American Chemical Society 2008;130(11):3645-51.
2008: Lewis Jared C; Berman Ashley M; Bergman Robert G; Ellman Jonathan A
Rh(I)-catalyzed arylation of heterocycles via C-H bond activation: expanded scope through mechanistic insight.
Journal of the American Chemical Society 2008;130(8):2493-500.
2008: Yotphan Sirilata; Bergman Robert G; Ellman Jonathan A
The stereoselective formation of bicyclic enamines with bridgehead unsaturation via tandem C-H bond activation/alkenylation/electrocyclization.
Journal of the American Chemical Society 2008;130(8):2452-3.
2008: Trincado Mónica; Ellman Jonathan A
Enantioselective synthesis of alpha-aryl alkylamines by Rh-catalyzed addition reactions of arylboronic acids to aliphatic imines.
Angewandte Chemie (International ed. in English) 2008;47(30):5623-6.
2007: Robak MaryAnn T; Trincado Monica; Ellman Jonathan A
Enantioselective aza-Henry reaction with an N-sulfinyl urea organocatalyst.
Journal of the American Chemical Society 2007;129(49):15110-1.
2007: Nakagawa Hiroshi; Rech Jason C; Sindelar Robert W; Ellman Jonathan A
Catalytic enantioselective addition of arylboronic acids to N-boc imines generated in situ.
Organic letters 2007;9(25):5155-7.
2007: Soellner Matthew B; Rawls Katherine A; Grundner Christoph; Alber Tom; Ellman Jonathan A
Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB.
Journal of the American Chemical Society 2007;129(31):9613-5.
2007: Liu Gang L; Rosa-Bauza Yazmin T; Salisbury Cleo M; Craik Charles; Ellman Jonathan A; Chen Fanqing Frank; Lee Luke P
Peptide-nanoparticle hybrid SERS probes for optical detection of protease activity.
Journal of nanoscience and nanotechnology 2007;7(7):2323-30.
2007: Rosa-Bauzá Yazmín T; Berst Frederic; Ellman Jonathan A
Straightforward preparation and assay of aspartyl protease substrates with an internal thioester linkage.
Chembiochem : a European journal of chemical biology 2007;8(9):981-4.
2007: Ellman Jonathan A
Chemistry. The direct approach.
Science (New York, N.Y.) 2007;316(5828):1131-2.
2007: Inagaki Hiroaki; Tsuruoka Hiroyuki; Hornsby Michael; Lesley Scott A; Spraggon Glen; Ellman Jonathan A
Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode.
Journal of medicinal chemistry 2007;50(11):2693-9.
2007: Lewis Jared C; Bergman Robert G; Ellman Jonathan A
Rh(I)-catalyzed alkylation of quinolines and pyridines via C-H bond activation.
Journal of the American Chemical Society 2007;129(17):5332-3.
2007: Rech Jason C; Yato Michihisa; Duckett Derek; Ember Brian; LoGrasso Philip V; Bergman Robert G; Ellman Jonathan A
Synthesis of potent bicyclic bisarylimidazole c-Jun N-terminal kinase inhibitors by catalytic C-H bond activation.
Journal of the American Chemical Society 2007;129(3):490-1.
2007: Tanuwidjaja Jessica; Peltier Hillary M; Ellman Jonathan A
One-pot asymmetric synthesis of either diastereomer of tert-butanesulfinyl-protected amines from ketones.
The Journal of organic chemistry 2007;72(2):626-9.
2007: Patterson Andrew W; Peltier Hillary M; Sasse Florenz; Ellman Jonathan A
Design, synthesis, and biological properties of highly potent tubulysin D analogues.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(34):9534-41.
2007: Patterson Andrew W; Wood Warren J L; Ellman Jonathan A
Substrate activity screening (SAS): a general procedure for the preparation and screening of a fragment-based non-peptidic protease substrate library for inhibitor discovery.
Nature protocols 2007;2(2):424-33.
2006: Peltier Hillary M; McMahon Jeffrey P; Patterson Andrew W; Ellman Jonathan A
The total synthesis of tubulysin D.
Journal of the American Chemical Society 2006;128(50):16018-9.
2006: Patterson Andrew W; Wood Warren J L; Hornsby Michael; Lesley Scott; Spraggon Glen; Ellman Jonathan A
Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.
Journal of medicinal chemistry 2006;49(21):6298-307.
2006: Patterson Andrew W; Ellman Jonathan A
Asymmetric synthesis of alpha,alpha-dibranched propargylamines by acetylide additions to N-tert-butanesulfinyl ketimines.
The Journal of organic chemistry 2006;71(18):7110-2.
2006: Watzke Anja; O'Malley Steven J; Bergman Robert G; Ellman Jonathan A
Reassignment of the configuration of salvianolic acid B and establishment of its identity with lithospermic acid B.
Journal of natural products 2006;69(8):1231-3.
2006: Gosalia Dhaval N; Denney William S; Salisbury Cleo M; Ellman Jonathan A; Diamond Scott L
Functional phenotyping of human plasma using a 361-fluorogenic substrate biosensing microarray.
Biotechnology and bioengineering 2006;94(6):1099-110.
2006: Salisbury Cleo M; Ellman Jonathan A
Rapid identification of potent nonpeptidic serine protease inhibitors.
Chembiochem : a European journal of chemical biology 2006;7(7):1034-7.
2006: Beenen Melissa A; Weix Daniel J; Ellman Jonathan A
Asymmetric synthesis of protected arylglycines by rhodium-catalyzed addition of arylboronic acids to N-tert-butanesulfinyl imino esters.
Journal of the American Chemical Society 2006;128(19):6304-5.
2006: Colby Denise A; Bergman Robert G; Ellman Jonathan A
Stereoselective alkylation of alpha,beta-unsaturated imines via C-H bond activation.
Journal of the American Chemical Society 2006;128(17):5604-5.
2006: Choe Youngchool; Leonetti Francesco; Greenbaum Doron C; Lecaille Fabien; Bogyo Matthew; Brömme Dieter; Ellman Jonathan A; Craik Charles S
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities.
The Journal of biological chemistry 2006;281(18):12824-32.
2006: Wilson Rebecca M; Thalji Reema K; Bergman Robert G; Ellman Jonathan A
Enantioselective synthesis of a PKC inhibitor via catalytic C-H bond activation.
Organic letters 2006;8(8):1745-7.
2006: Wiedemann Sean H; Ellman Jonathan A; Bergman Robert G
Rhodium-catalyzed direct C-H addition of 3,4-dihydroquinazolines to alkenes and their use in the total synthesis of vasicoline.
The Journal of organic chemistry 2006;71(5):1969-76.
2006: Wiedemann Sean H; Lewis Jared C; Ellman Jonathan A; Bergman Robert G
Experimental and computational studies on the mechanism of N-heterocycle C-H activation by Rh(I).
Journal of the American Chemical Society 2006;128(7):2452-62.
2006: Lewis Jared C; Wu Jessica Y; Bergman Robert G; Ellman Jonathan A
Microwave-promoted rhodium-catalyzed arylation of heterocycles through C--H bond activation.
Angewandte Chemie (International ed. in English) 2006;45(10):1589-91.
2006: Liu Gang L; Chen F Frank; Ellman Jonathan A; Lee Luke P
Peptide-nanoparticle hybrid SERS probe for dynamic detection of active cancer biomarker enzymes.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2006;1():795-8.
2005: McMahon Jeffrey P; Ellman Jonathan A
Asymmetric conjugate addition of copper reagents to alpha,beta-unsaturated tert-butanesulfinyl imines.
Organic letters 2005;7(24):5393-6.
2005: Wood Warren J L; Patterson Andrew W; Tsuruoka Hiroyuki; Jain Rishi K; Ellman Jonathan A
Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitors.
Journal of the American Chemical Society 2005;127(44):15521-7.
2005: O'Malley Steven J; Tan Kian L; Watzke Anja; Bergman Robert G; Ellman Jonathan A
Total synthesis of (+)-lithospermic acid by asymmetric intramolecular alkylation via catalytic C-H bond activation.
Journal of the American Chemical Society 2005;127(39):13496-7.
2005: Peltier Hillary M; Ellman Jonathan A
N-sulfinyl metalloenamine conjugate additions: asymmetric synthesis of piperidines.
The Journal of organic chemistry 2005;70(18):7342-5.
2005: Thalji Reema K; Ahrendt Kateri A; Bergman Robert G; Ellman Jonathan A
Annulation of aromatic imines via directed C-H bond activation.
The Journal of organic chemistry 2005;70(17):6775-81.
2005: Brinner Kristin M; Ellman Jonathan A
A rapid and general method for the asymmetric synthesis of 2-substituted pyrrolidines using tert-butanesulfinamide.
Organic & biomolecular chemistry 2005;3(11):2109-13.
2005: Gosalia Dhaval N; Salisbury Cleo M; Ellman Jonathan A; Diamond Scott L
High throughput substrate specificity profiling of serine and cysteine proteases using solution-phase fluorogenic peptide microarrays.
Molecular & cellular proteomics : MCP 2005;4(5):626-36.
2005: Peltier Hillary M; Evans Jared W; Ellman Jonathan A
Catalytic enantioselective sulfinyl transfer using cinchona alkaloid catalysts.
Organic letters 2005;7(9):1733-6.
2005: Gosalia Dhaval N; Salisbury Cleo M; Maly Dustin J; Ellman Jonathan A; Diamond Scott L
Profiling serine protease substrate specificity with solution phase fluorogenic peptide microarrays.
Proteomics 2005;5(5):1292-8.
2005: Weix Daniel J; Shi Yili; Ellman Jonathan A
Diastereoselective and enantioselective Rh(I)-catalyzed additions of arylboronic acids to N-tert-butanesulfinyl and N-diphenylphosphinoyl aldimines.
Journal of the American Chemical Society 2005;127(4):1092-3.
2005: Brinner Kristin M; Powles Mary Ann; Schmatz Dennis M; Ellman Jonathan A
Potent 4-aminopiperidine based antimalarial agents.
Bioorganic & medicinal chemistry letters 2005;15(2):345-8.
2004: Kochi Takuya; Ellman Jonathan A
Asymmetric alpha-alkylation of N'-tert-butanesulfinyl amidines. Application to the total synthesis of (6R,7S)-7-amino-7,8-dihydro-alpha-bisabolene.
Journal of the American Chemical Society 2004;126(48):15652-3.
2004: Tan Kian L; Park Steve; Ellman Jonathan A; Bergman Robert G
Intermolecular coupling of alkenes to heterocycles via C-H bond activation.
The Journal of organic chemistry 2004;69(21):7329-35.
2004: Schenkel Laurie B; Ellman Jonathan A
Self-condensation of N-tert-butanesulfinyl aldimines: application to the rapid asymmetric synthesis of biologically important amine-containing compounds.
Organic letters 2004;6(20):3621-4.
2004: Evans Jared W; Fierman Matthew B; Miller Scott J; Ellman Jonathan A
Catalytic enantioselective synthesis of sulfinate esters through the dynamic resolution of tert-butanesulfinyl chloride.
Journal of the American Chemical Society 2004;126(26):8134-5.
2004: Thalji Reema K; Ellman Jonathan A; Bergman Robert G
Highly efficient and enantioselective cyclization of aromatic imines via directed C-H bond activation.
Journal of the American Chemical Society 2004;126(23):7192-3.
2004: Wiedemann Sean H; Bergman Robert G; Ellman Jonathan A
Rhodium-catalyzed direct C-H addition of 4,4-dimethyl-2-oxazoline to alkenes.
Organic letters 2004;6(10):1685-7.
2004: McMahon Jeffrey P; Ellman Jonathan A
Highly stereoselective addition of organometallic reagents to N-tert-butanesulfinyl imines derived from 3- and 4-substituted cyclohexanones.
Organic letters 2004;6(10):1645-7.
2004: Schenkel Laurie B; Ellman Jonathan A
Application of P,N-sulfinyl imine ligands to iridium-catalyzed asymmetric hydrogenation of olefins.
The Journal of organic chemistry 2004;69(6):1800-2.
2004: Lewis Jared C; Wiedemann Sean H; Bergman Robert G; Ellman Jonathan A
Arylation of heterocycles via rhodium-catalyzed C-H bond functionalization.
Organic letters 2004;6(1):35-8.
2003: Evans Jared W; Ellman Jonathan A
Stereoselective synthesis of 1,2-disubstituted beta-amino alcohols by nucleophilic addition to N-tert-butanesulfinyl alpha-alkoxyaldimines.
The Journal of organic chemistry 2003;68(26):9948-57.
2003: Wood Warren J L; Huang Lily; Ellman Jonathan A
Synthesis of a diverse library of mechanism-based cysteine protease inhibitors.
Journal of combinatorial chemistry 2003;5(6):869-80.
2003: Kochi Takuya; Tang Tony P; Ellman Jonathan A
Development and application of a new general method for the asymmetric synthesis of syn- and anti-1,3-amino alcohols.
Journal of the American Chemical Society 2003;125(37):11276-82.
2003: Jain Rishi K; Trias Joaquim; Ellman Jonathan A
D-Ala-D-lac binding is not required for the high activity of vancomycin dimers against vancomycin resistant enterococci.
Journal of the American Chemical Society 2003;125(29):8740-1.
2003: Tan Kian L; Vasudevan Anil; Bergman Robert G; Ellman Jonathan A; Souers Andrew J
Microwave-assisted C-H bond activation: a rapid entry into functionalized heterocycles.
Organic letters 2003;5(12):2131-4.
2003: Ahrendt Kateri A; Olsen Jacob A; Wakao Masahiro; Trias Joaquim; Ellman Jonathan A
Identification of potent and broad-spectrum antibiotics from SAR studies of a synthetic vancomycin analogue.
Bioorganic & medicinal chemistry letters 2003;13(10):1683-6.
2003: Weix Daniel J; Ellman Jonathan A
Improved synthesis of tert-butanesulfinamide suitable for large-scale production.
Organic letters 2003;5(8):1317-20.
2003: Ahrendt Kateri A; Bergman Robert G; Ellman Jonathan A
Synthesis of a tricyclic mescaline analogue by catalytic C-H bond activation.
Organic letters 2003;5(8):1301-3.
2003: Leiting Barbara; Pryor KellyAnn D; Wu Joseph K; Marsilio Frank; Patel Reshma A; Craik Charles S; Ellman Jonathan A; Cummings Richard T; Thornberry Nancy A
Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII.
The Biochemical journal 2003;371(Pt 2):525-32.
2003: Asojo Oluwatoyin A; Gulnik Sergei V; Afonina Elena; Yu Betty; Ellman Jonathan A; Haque Tasir S; Silva Abelardo M
Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum.
Journal of molecular biology 2003;327(1):173-81.
2003: Schenkel Laurie B; Ellman Jonathan A
Novel sulfinyl imine ligands for asymmetric catalysis.
Organic letters 2003;5(4):545-8.
2003: Cawley Niamh X; Chino Masao; Maldonado Alex; Rodriguez Yazmin M; Loh Y Peng; Ellman Jonathan A
Synthesis and characterization of the first potent inhibitor of yapsin 1. Implications for the study of yapsin-like enzymes.
The Journal of biological chemistry 2003;278(8):5523-30.
2003: Blum Suzanne A; Bergman Robert G; Ellman Jonathan A
Enantioselective oxidation of di-tert-butyl disulfide with a vanadium catalyst: progress toward mechanism elucidation.
The Journal of organic chemistry 2003;68(1):150-5.
2003: Owens Timothy D; Souers Andrew J; Ellman Jonathan A
The preparation and utility of bis(sulfinyl)imidoamidine ligands for the copper-catalyzed Diels-Alder reaction.
The Journal of organic chemistry 2003;68(1):3-10.
2003: Huang Lily; Brinen Linda S; Ellman Jonathan A
Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain.
Bioorganic & medicinal chemistry 2003;11(1):21-9.
2002: Salisbury Cleo M; Maly Dustin J; Ellman Jonathan A
Peptide microarrays for the determination of protease substrate specificity.
Journal of the American Chemical Society 2002;124(50):14868-70.
2002: Tan Kian L; Bergman Robert G; Ellman Jonathan A
Intermolecular coupling of isomerizable alkenes to heterocycles via rhodium-catalyzed C-H bond activation.
Journal of the American Chemical Society 2002;124(47):13964-5.
2002: Ellman Jonathan A; Owens Timothy D; Tang Tony P
N-tert-butanesulfinyl imines: versatile intermediates for the asymmetric synthesis of amines.
Accounts of chemical research 2002;35(11):984-95.
2002: Tang Tony P; Ellman Jonathan A
Asymmetric synthesis of beta-amino acid derivatives incorporating a broad range of substitution patterns by enolate additions to tert-butanesulfinyl imines.
The Journal of organic chemistry 2002;67(22):7819-32.
2002: Brinner Kristin M; Mi Kim Jin; Habashita Hiromu; Gluzman Ilya Y; Goldberg Daniel E; Ellman Jonathan A
Novel and potent anti-malarial agents.
Bioorganic & medicinal chemistry 2002;10(11):3649-61.
2002: Huang Lily; Ellman Jonathan A
General solid-phase method to prepare novel cyclic ketone inhibitors of the cysteine protease cruzain.
Bioorganic & medicinal chemistry letters 2002;12(20):2993-6.
2002: Choi Clara Y H; Schneider Eric L; Kim Jin M; Gluzman Ilya Y; Goldberg Daniel E; Ellman Jonathan A; Marletta Michael A
Interference with heme binding to histidine-rich protein-2 as an antimalarial strategy.
Chemistry & biology 2002;9(8):881-9.
2002: Wang Xueqing; Choe Youngchool; Craik Charles S; Ellman Jonathan A
Design and synthesis of novel inhibitors of gelatinase B.
Bioorganic & medicinal chemistry letters 2002;12(16):2201-4.
2002: Kochi Takuya; Tang Tony P; Ellman Jonathan A
Asymmetric synthesis of syn- and anti-1,3-amino alcohols.
Journal of the American Chemical Society 2002;124(23):6518-9.
2002: Tan Kian L; Bergman Robert G; Ellman Jonathan A
Intermediacy of an N-heterocyclic carbene complex in the catalytic C-H activation of a substituted benzimidazole.
Journal of the American Chemical Society 2002;124(13):3202-3.
2002: Maly Dustin J; Leonetti Francesco; Backes Bradley J; Dauber Deborah S; Harris Jennifer L; Craik Charles S; Ellman Jonathan A
Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore.
The Journal of organic chemistry 2002;67(3):910-5.
2002: Kehoe John W; Maly Dustin J; Verdugo Dawn E; Armstrong Joshua I; Cook Brian N; Ouyang Ying-Bin; Moore Kevin L; Ellman Jonathan A; Bertozzi Carolyn R
Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly.
Bioorganic & medicinal chemistry letters 2002;12(3):329-32.
2002: Dauber Deborah S; Ziermann Rainer; Parkin Neil; Maly Dustin J; Mahrus Sami; Harris Jennifer L; Ellman Jon A; Petropoulos Christos; Craik Charles S
Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease.
Journal of virology 2002;76(3):1359-68.
2002: Maly Dustin J; Huang Lily; Ellman Jonathan A
Combinatorial strategies for targeting protein families: application to the proteases.
Chembiochem : a European journal of chemical biology 2002;3(1):16-37.
2002: Huang Lily; Lee Alice; Ellman Jonathan A
Identification of potent and selective mechanism-based inhibitors of the cysteine protease cruzain using solid-phase parallel synthesis.
Journal of medicinal chemistry 2002;45(3):676-84.
2001: Tang T P; Volkman S K; Ellman J A
Asymmetric synthesis of protected 1,2-amino alcohols using tert-butanesulfinyl aldimines and ketimines.
The Journal of organic chemistry 2001;66(26):8772-8.
2001: Lee A; Ellman J A
Parallel solution-phase synthesis of mechanism-based cysteine protease inhibitors.
Organic letters 2001;3(23):3707-9.
2001: Dragoli D R; Burdett M T; Ellman J A
Design, synthesis, and utility of a support-bound tert-butanesulfinamide.
Journal of the American Chemical Society 2001;123(41):10127-8.
2001: Thalji R K; Ahrendt K A; Bergman R G; Ellman J A
Annulation of aromatic imines via directed C-H activation with Wilkinson's catalyst.
Journal of the American Chemical Society 2001;123(39):9692-3.
2001: Souers A J; Owens T D; Oliver A G; Hollander F J; Ellman J A
Synthesis and crystal structure of a unique and homochiral N,S-bonded N,N'-bis(tert-butanesulfinyl)amidinate rhodium(I) complex.
Inorganic chemistry 2001;40(20):5299-301.
2001: Harris J L; Niles A; Burdick K; Maffitt M; Backes B J; Ellman J A; Kuntz I; Haak-Frendscho M; Craik C S
Definition of the extended substrate specificity determinants for beta-tryptases I and II.
The Journal of biological chemistry 2001;276(37):34941-7.
2001: Tan K L; Bergman R G; Ellman J A
Annulation of alkenyl-substituted heterocycles via rhodium-catalyzed intramolecular C-H activated coupling reactions.
Journal of the American Chemical Society 2001;123(11):2685-6.
2000: Souers A J; Rosenquist A; Jarvie E M; Ladlow M; Feniuk W; Ellman J A
Optimization of a somatostatin mimetic via constrained amino acid and backbone incorporation.
Bioorganic & medicinal chemistry letters 2000;10(24):2731-3.
2000: Harris J L; Backes B J; Leonetti F; Mahrus S; Ellman J A; Craik C S
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7754-9.
2000: Bi X; Haque T S; Zhou J; Skillman A G; Lin B; Lee C E; Kuntz I D; Ellman J A; Lynch G
Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus.
Journal of neurochemistry 2000;74(4):1469-77.
2000: Maly D J; Choong I C; Ellman J A
Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2419-24.
2000: Souers A J; Ellman J A
Asymmetric synthesis of a C-3 substituted pipecolic acid.
The Journal of organic chemistry 2000;65(4):1222-4.
2000: Backes B J; Harris J L; Leonetti F; Craik C S; Ellman J A
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin.
Nature biotechnology 2000;18(2):187-93.
2000: Ellman J A
Combinatorial methods to engineer small molecules for functional genomics.
Ernst Schering Research Foundation workshop 2000;(32):183-204.
1999: Dragoli D R; Thompson L A; O'Brien J; Ellman J A
Parallel synthesis of prostaglandin E1 analogues.
Journal of combinatorial chemistry 1999;1(6):534-9.
1999: Haskell-Luevano C; Rosenquist A; Souers A; Khong K C; Ellman J A; Cone R D
Compounds that activate the mouse melanocortin-1 receptor identified by screening a small molecule library based upon the beta-turn.
Journal of medicinal chemistry 1999;42(21):4380-7.
1999: Haque T S; Skillman A G; Lee C E; Habashita H; Gluzman I Y; Ewing T J; Goldberg D E; Kuntz I D; Ellman J A
Potent, low-molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II.
Journal of medicinal chemistry 1999;42(8):1428-40.
1998: Souers A J; Virgilio A A; Schürer S S; Ellman J A; Kogan T P; West H E; Ankener W; Vanderslice P
Novel inhibitors of alpha 4 beta 1 integrin receptor interactions through library synthesis and screening.
Bioorganic & medicinal chemistry letters 1998;8(17):2297-302.
1998: Ellman J A; Gallop M A
Combinatorial chemistry.
Current opinion in chemical biology 1998;2(3):317-9.
1997: Backes B J; Ellman J A
Solid support linker strategies.
Current opinion in chemical biology 1997;1(1):86-93.
1997: Kick E K; Roe D C; Skillman A G; Liu G; Ewing T J; Sun Y; Kuntz I D; Ellman J A
Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D.
Chemistry & biology 1997;4(4):297-307.
1997: Ellman J; Stoddard B; Wells J
Combinatorial thinking in chemistry and biology.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):2779-82.
1997: Plunkett M J; Ellman J A
Combinatorial chemistry and new drugs.
Scientific American 1997;276(4):68-73.
1996: Bunin B A; Plunkett M J; Ellman J A
Synthesis and evaluation of 1,4-benzodiazepine libraries.
Methods in enzymology 1996;267():448-65.
1995: Kick E K; Ellman J A
Expedient method for the solid-phase synthesis of aspartic acid protease inhibitors directed toward the generation of libraries.
Journal of medicinal chemistry 1995;38(9):1427-30.
1994: Bunin B A; Plunkett M J; Ellman J A
The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4708-12.
1992: Mendel D; Ellman J A; Chang Z; Veenstra D L; Kollman P A; Schultz P G
Probing protein stability with unnatural amino acids.
Science (New York, N.Y.) 1992;256(5065):1798-802.
1992: Ellman J A; Mendel D; Schultz P G
Site-specific incorporation of novel backbone structures into proteins.
Science (New York, N.Y.) 1992;255(5041):197-200.
1991: Ellman J; Mendel D; Anthony-Cahill S; Noren C J; Schultz P G
Biosynthetic method for introducing unnatural amino acids site-specifically into proteins.
Methods in enzymology 1991;202():301-36.

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