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Joachim Ellwart

Research Profile

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Autoimmune Experimental Encephalomyelitis

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Baowei Su; Joana R Viola; Ernst Wagner; Martina Anton; Arzu Cengizeroglu; Joachim W Ellwart; Katarina Farkasova; Rudolf Haase; Manfred Ogris
Systemic TNFα gene therapy synergizes with liposomal doxorubicine in the treatment of metastatic cancer.
Prajakta S Oak; Ulf R Rapp; Joachim W Ellwart; Pjotr Knyazev; Florian Kopp; Chitra Thakur; Axel Ullrich; Ernst Wagner; Andreas Roidl
Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2-positive cancer cells and cancer stem cells.
Francesca Odoardi; Christian Schläger; Christopher Sie; Rainer Spang; Kristina Streyl; Vijay K Ulaganathan; Martin Vingron; Hartmut Wekerle; Cassandra Flügel-Koch; Klaus Heckelsmiller; Wolfgang E F Klinkert; Hans Lehrach; Dmitri Lodygin; Claudio Lottaz; Wilfried Nietfeld; Mikhail Nosov; Volker Brinkmann; Joachim W Ellwart; Alexander Flügel
T cells become licensed in the lung to enter the central nervous system.

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All Publications

2013: Baowei Su; Joana R Viola; Ernst Wagner; Martina Anton; Arzu Cengizeroglu; Joachim W Ellwart; Katarina Farkasova; Rudolf Haase; Manfred Ogris
Systemic TNFα gene therapy synergizes with liposomal doxorubicine in the treatment of metastatic cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(2):300-8.
2012: Prajakta S Oak; Ulf R Rapp; Joachim W Ellwart; Pjotr Knyazev; Florian Kopp; Chitra Thakur; Axel Ullrich; Ernst Wagner; Andreas Roidl
Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2-positive cancer cells and cancer stem cells.
International journal of cancer. Journal international du cancer 2012;131(12):2808-19.
2012: Francesca Odoardi; Christian Schläger; Christopher Sie; Rainer Spang; Kristina Streyl; Vijay K Ulaganathan; Martin Vingron; Hartmut Wekerle; Cassandra Flügel-Koch; Klaus Heckelsmiller; Wolfgang E F Klinkert; Hans Lehrach; Dmitri Lodygin; Claudio Lottaz; Wilfried Nietfeld; Mikhail Nosov; Volker Brinkmann; Joachim W Ellwart; Alexander Flügel
T cells become licensed in the lung to enter the central nervous system.
Nature 2012;488(7413):675-9.
2012: Thomas Magg; Joachim Mannert; Irene Schmid; Joachim W Ellwart; Michael H Albert
Subcellular localization of FOXP3 in human regulatory and nonregulatory T cells.
European journal of immunology 2012;42(6):1627-38.
2012: Theresa M Schwarz; Alexandra Aicher; Frank Berger; Wolfgang Böcker; Joachim W Ellwart; Patrick C Hermann; Simon F Leicht; Tamara Radic; Iker Rodriguez-Araboalaza; Jaimy Saif; Christopher Heeschen
Vascular incorporation of endothelial colony-forming cells is essential for functional recovery of murine ischemic tissue following cell therapy.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(2):e13-21.
2011: David Anz; Carole Bourquin; Jonathan Ellermeier; Joachim W Ellwart; Michaela Golic; Viktor H Koelzer; Wolfgang G Kunz; Wolfgang Mueller; Moritz Rapp; Max Schnurr; Stefan Endres
CD103 is a hallmark of tumor-infiltrating regulatory T cells.
International journal of cancer. Journal international du cancer 2011;129(10):2417-26.
2011: Martin Kantlehner; Roland Kirchner; Petra Hartmann; Joachim W Ellwart; Marianna Alunni-Fabbroni; Axel Schumacher
A high-throughput DNA methylation analysis of a single cell.
Nucleic acids research 2011;39(7):e44.
2011: Eike Gallmeier; Patrick C Hermann; Maria-Theresa Mueller; Juan G Machado; Andreas Ziesch; Enrico N De Toni; Andreas Palagyi; Christian Eisen; Joachim W Ellwart; Jose Rivera; Belen Rubio-Viqueira; Manuel Hidalgo; Fred Bunz; Burkhard Göke; Christopher Heeschen
Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133(+) tumor-initiating cell fraction.
Stem cells (Dayton, Ohio) 2011;29(3):418-29.
2010: Peer-Hendrik Kuhn; Huanhuan Wang; Bastian Dislich; Alessio Colombo; Ulrike Zeitschel; Joachim W Ellwart; Elisabeth Kremmer; Steffen Rossner; Stefan F Lichtenthaler
ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.
The EMBO journal 2010;29(17):3020-32.
2010: Xiaoling Liang; Luise Ullrike Weigand; Ingrid G Schuster; Elfriede Eppinger; Judith C van der Griendt; Andrea Schub; Matthias Leisegang; Daniel Sommermeyer; Florian Anderl; Yanyan Han; Joachim W Ellwart; Andreas Moosmann; Dirk H Busch; Wolfgang Uckert; Christian Peschel; Angela M Krackhardt
A single TCR alpha-chain with dominant peptide recognition in the allorestricted HER2/neu-specific T cell repertoire.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(3):1617-29.
2009: Ingo Bartholomäus; Naoto Kawakami; Francesca Odoardi; Christian Schläger; Djordje Miljkovic; Joachim W Ellwart; Wolfgang E F Klinkert; Cassandra Flügel-Koch; Thomas B Issekutz; Hartmut Wekerle; Alexander Flügel
Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions.
Nature 2009;462(7269):94-8.
2009: Maria-Theresa Mueller; Patrick C Hermann; Juliane Witthauer; Belen Rubio-Viqueira; Simon F Leicht; Stephan Huber; Joachim W Ellwart; Mona Mustafa; Peter Bartenstein; Jan G D'Haese; Michael H Schoenberg; Frank Berger; Karl-Walter Jauch; Manuel Hidalgo; Christopher Heeschen
Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer.
Gastroenterology 2009;137(3):1102-13.
2008: Henriette Bendz; Boris-Christian Marincek; Frank Momburg; Joachim W Ellwart; Rolf Issels; Peter J Nelson; Elfriede Noessner
Calcium signaling in dendritic cells by human or mycobacterial Hsp70 is caused by contamination and is not required for Hsp70-mediated enhancement of cross-presentation.
The Journal of biological chemistry 2008;283(39):26477-83.
2008: K Mark Ansel; William A Pastor; Nicola Rath; Ariya D Lapan; Elke Glasmacher; Christine Wolf; Laura C Smith; Nikoletta Papadopoulou; Edward D Lamperti; Mamta Tahiliani; Joachim W Ellwart; Yujiang Shi; Elisabeth Kremmer; Anjana Rao; Vigo Heissmeyer
Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing.
Nature structural & molecular biology 2008;15(5):523-30.
2008: Sabine Lutz-Bonengel; Timo Sänger; Walther Parson; Helena Müller; Joachim W Ellwart; Marie Follo; Bernhard Bonengel; Harald Niederstätter; Marielle Heinrich; Ulrike Schmidt
Single lymphocytes from two healthy individuals with mitochondrial point heteroplasmy are mainly homoplasmic.
International journal of legal medicine 2008;122(3):189-97.
2008: Hiroshi Arakawa; Hiroaki Kudo; Vera Batrak; Randolph B Caldwell; Michael A Rieger; Joachim W Ellwart; Jean-Marie Buerstedde
Protein evolution by hypermutation and selection in the B cell line DT40.
Nucleic acids research 2008;36(1):e1.
2007: Ingrid G Schuster; Dirk H Busch; Elfriede Eppinger; Elisabeth Kremmer; Slavoljub Milosevic; Christine Hennard; Christina Kuttler; Joachim W Ellwart; Bernhard Frankenberger; Elfriede Nössner; Christoph Salat; Christian Bogner; Arndt Borkhardt; Hans-Jochem Kolb; Angela M Krackhardt
Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignancies.
Blood 2007;110(8):2931-9.
2007: Patrick C Hermann; Stephan Huber; Tanja Herrler; Alexandra Aicher; Joachim W Ellwart; Markus Guba; Christiane J Bruns; Christopher Heeschen
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer.
Cell stem cell 2007;1(3):313-23.
2007: Tatjana Dorn; Ursula Kuhn; Gerd Bungartz; Sebastian Stiller; Martina Bauer; Joachim W Ellwart; Thorsten Peters; Karin Scharffetter-Kochanek; Monika Semmrich; Melanie Laschinger; Bernhard Holzmann; Wolfgang E F Klinkert; Per thor Straten; Tania Køllgaard; Michael Sixt; Cord Brakebusch
RhoH is important for positive thymocyte selection and T-cell receptor signaling.
Blood 2007;109(6):2346-55.
2007: Alexandra Aicher; Markus Rentsch; Ken-ichiro Sasaki; Joachim W Ellwart; Fred Fändrich; Reiner Siebert; john cooke; Stefanie Dimmeler; Christopher Heeschen
Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia.
Circulation research 2007;100(4):581-9.
2007: Francesca Odoardi; Naoto Kawakami; Zhaoxia Li; Chiara Cordiglieri; Kristina Streyl; Mikhail Nosov; Wolfgang E F Klinkert; Joachim W Ellwart; Jan Bauer; Hans Lassmann; Hartmut Wekerle; Alexander Flügel
Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(3):920-5.
2006: Laura Diluvio; Sigrid Vollmer; Petra Besgen; Joachim W Ellwart; Sergio Chimenti; Jörg Christoph Prinz
Identical TCR beta-chain rearrangements in streptococcal angina and skin lesions of patients with psoriasis vulgaris.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):7104-11.
2006: Carola Reindl; Ksenia Bagrintseva; Sridhar Vempati; Susanne Schnittger; Joachim W Ellwart; Katja Wenig; Karl-Peter Hopfner; Wolfgang Hiddemann; Karsten Spiekermann
Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML.
Blood 2006;107(9):3700-7.
2006: Huseyin Saribasak; Nesibe Nur Saribasak; Fatih M Ipek; Joachim W Ellwart; Hiroshi Arakawa; Jean-Marie Buerstedde
Uracil DNA glycosylase disruption blocks Ig gene conversion and induces transition mutations.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):365-71.
2005: Ksenia Bagrintseva; Stefanie Geisenhof; Ruth Kern; Sabine Eichenlaub; Carola Reindl; Joachim W Ellwart; Wolfgang Hiddemann; Karsten Spiekermann
FLT3-ITD-TKD dual mutants associated with AML confer resistance to FLT3 PTK inhibitors and cytotoxic agents by overexpression of Bcl-x(L).
Blood 2005;105(9):3679-85.
2005: Tobias M Kohl; Susanne Schnittger; Joachim W Ellwart; Wolfgang Hiddemann; Karsten Spiekermann
KIT exon 8 mutations associated with core-binding factor (CBF)-acute myeloid leukemia (AML) cause hyperactivation of the receptor in response to stem cell factor.
Blood 2005;105(8):3319-21.
2005: Matthias Mack; Martin A Schneider; Cordula Moll; Josef Cihak; Hilke Brühl; Joachim W Ellwart; Mark P Hogarth; Manfred Stangassinger; Detlef Schlöndorff
Identification of antigen-capturing cells as basophils.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(2):735-41.
2005: Mathias Gehrmann; Jörg Marienhagen; Hedda Eichholtz-Wirth; E Fritz; Joachim W Ellwart; Marja Jäättelä; Tanja Zilch; Gabriele Multhoff
Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells.
Cell death and differentiation 2005;12(1):38-51.
2004: Guido A Drexler; Susanne Wilde; Wolfgang Beisker; Joachim W Ellwart; Friederike Eckardt-Schupp; Eberhard Fritz
The rate of extrachromosomal homologous recombination within a novel reporter plasmid is elevated in cells lacking functional ATM protein.
DNA repair 2004;3(10):1345-53.
2004: Stephan Bathe; Michael Lebuhn; Joachim W Ellwart; Stefan Wuertz; Martina Hausner
High phylogenetic diversity of transconjugants carrying plasmid pJP4 in an activated sludge-derived microbial community.
FEMS microbiology letters 2004;235(2):215-9.
2004: Ksenia Bagrintseva; Ruth Schwab; Tobias M Kohl; Susanne Schnittger; Sabine Eichenlaub; Joachim W Ellwart; Wolfgang Hiddemann; Karsten Spiekermann
Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells.
Blood 2004;103(6):2266-75.
2004: Peter Ruf; Michael Jäger; Joachim W Ellwart; Susanne Wosch; Elisabeth Kusterer; Horst Lindhofer
Two new trifunctional antibodies for the therapy of human malignant melanoma.
International journal of cancer. Journal international du cancer 2004;108(5):725-32.
2004: Naoto Kawakami; Silke Lassmann; Zhaoxia Li; Francesca Odoardi; Thomas Ritter; Tjalf Ziemssen; Wolfgang E F Klinkert; Joachim W Ellwart; Monika Bradl; Kimberly Krivacic; Hans Lassmann; Richard M Ransohoff; Hans-Dieter Volk; Hartmut Wekerle; Christopher Linington; Alexander Flügel
The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis.
The Journal of experimental medicine 2004;199(2):185-97.
2004: Robert Gastpar; Catharina Gross; Lydia Rossbacher; Joachim W Ellwart; Julia Riegger; Gabriele Multhoff
The cell surface-localized heat shock protein 70 epitope TKD induces migration and cytolytic activity selectively in human NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):972-80.
2004: Moritz Wagner; Hendrik Poeck; Bernd Jahrsdoerfer; Simon Rothenfusser; Domenik Prell; Barbara Bohle; Evelyn Tuma; Thomas Giese; Joachim W Ellwart; Stefan Endres; Gunther Hartmann
IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):954-63.
2004: Hilke Brühl; Josef Cihak; Martin A Schneider; Jirí Plachý; Tamara Rupp; Isabell Wenzel; Mehdi Shakarami; Stefan Milz; Joachim W Ellwart; Manfred Stangassinger; Detlef Schlöndorff; Matthias Mack
Dual role of CCR2 during initiation and progression of collagen-induced arthritis: evidence for regulatory activity of CCR2+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):890-8.
2003: Sibylle Mathys; Timm Schroeder; Joachim W Ellwart; Ulrich H Koszinowski; Martin Messerle; Ursula Just
Dendritic cells under influence of mouse cytomegalovirus have a physiologic dual role: to initiate and to restrict T cell activation.
The Journal of infectious diseases 2003;187(6):988-99.
2003: Matthias Ulbrecht; Valeska Hofmeister; Gülnihål Yüksekdag; Joachim W Ellwart; Hartmut Hengel; Frank Momburg; Silvia Martinozzi; Murielle Reboul; Marika Pla; Elisabeth H Weiss
HCMV glycoprotein US6 mediated inhibition of TAP does not affect HLA-E dependent protection of K-562 cells from NK cell lysis.
Human immunology 2003;64(2):231-7.
2003: Catharina Gross; Ingo G H Schmidt-Wolf; Srinivas Nagaraj; Robert Gastpar; Joachim W Ellwart; Leoni A Kunz-Schughart; Gabriele Multhoff
Heat shock protein 70-reactivity is associated with increased cell surface density of CD94/CD56 on primary natural killer cells.
Cell stress & chaperones 2003;8(4):348-60.
2002: Claudius Conrad; Berthold Gottgens; Sarah Kinston; Joachim W Ellwart; Ralf Huss
GATA transcription in a small rhodamine 123(low)CD34(+) subpopulation of a peripheral blood-derived CD34(-)CD105(+) mesenchymal cell line.
Experimental hematology 2002;30(8):887-95.
2001: Alexander Flügel; T Berkowicz; Thomas Ritter; M Labeur; Dieter E Jenne; Z Li; Joachim W Ellwart; Michael Willem; H Lassmann; Hartmut Wekerle
Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis.
Immunity 2001;14(5):547-60.
2000: Matthias Ulbrecht; Silvia Martinozzi; M Grzeschik; Hartmut Hengel; Joachim W Ellwart; Marika Pla; Elisabeth H Weiss
Cutting edge: the human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5019-22.
1999: C Botzler; Joachim W Ellwart; W Günther; Günther Eissner; Gabriele Multhoff
Synergistic effects of heat and ET-18-OCH3 on membrane expression of hsp70 and lysis of leukemic K562 cells.
Experimental hematology 1999;27(3):470-8.
1997: Gabriele Multhoff; C Botzler; L Jennen; J Schmidt; Joachim W Ellwart; Rolf Issels
Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4341-50.