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Eskil Elmér

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Karl Henrik Johannes Ehinger; Magnus J Hansson; Fredrik Sjövall; Eskil Elmér
Bioequivalence and tolerability assessment of a novel intravenous ciclosporin lipid emulsion compared to branded ciclosporin in Cremophor ® EL.
Fredrik Sjövall; Hiroyuki Uchino; Eleonor Asander Frostner; Einar Arnbjörnsson; Johannes K H Ehinger; Vineta Fellman; Magnus J Hansson; Johan Lundgren; Sigurður E Marelsson; Saori Morota; Eskil Elmér
Mitochondrial respiration in human viable platelets--methodology and influence of gender, age and storage.
Michael Karlsson; Jørgen A L Kurtzhals; Fredrik Sjövall; Magnus J Hansson; Casper Hempel; Eskil Elmér
Brain mitochondrial function in a murine model of cerebral malaria and the therapeutic effects of rhEPO.

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All Publications

2013: Karl Henrik Johannes Ehinger; Magnus J Hansson; Fredrik Sjövall; Eskil Elmér
Bioequivalence and tolerability assessment of a novel intravenous ciclosporin lipid emulsion compared to branded ciclosporin in Cremophor ® EL.
Clinical drug investigation 2013;33(1):25-34.
2013: Fredrik Sjövall; Hiroyuki Uchino; Eleonor Asander Frostner; Einar Arnbjörnsson; Johannes K H Ehinger; Vineta Fellman; Magnus J Hansson; Johan Lundgren; Sigurður E Marelsson; Saori Morota; Eskil Elmér
Mitochondrial respiration in human viable platelets--methodology and influence of gender, age and storage.
Mitochondrion 2013;13(1):7-14.
2013: Michael Karlsson; Jørgen A L Kurtzhals; Fredrik Sjövall; Magnus J Hansson; Casper Hempel; Eskil Elmér
Brain mitochondrial function in a murine model of cerebral malaria and the therapeutic effects of rhEPO.
The international journal of biochemistry & cell biology 2013;45(1):151-5.
2011: Per Levéen; H Kotarsky; Matthias Mörgelin; Riitta Karikoski; Eskil Elmér; Vineta Fellman
The GRACILE mutation introduced into Bcs1l causes postnatal complex III deficiency: a viable mouse model for mitochondrial hepatopathy.
Hepatology (Baltimore, Md.) 2011;53(2):437-47.
2011: Magnus J Hansson; Saori Morota; Li Chen; Nagahisa Matsuyama; Yoshiaki Suzuki; Satoshi Nakajima; Tadashi Tanoue; Akibumi Omi; Futoshi Shibasaki; Motohide Shimazu; Yukio Ikeda; Hiroyuki Uchino; Eskil Elmér
Cyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondria.
Journal of neurotrauma 2011;28(1):143-53.
2010: Fredrik Sjövall; Saori Morota; Magnus J Hansson; Hans Friberg; Erich Gnaiger; Eskil Elmér
Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis.
Critical care (London, England) 2010;14(6):R214.
2010: Roland Månsson; Saori Morota; Magnus J Hansson; Ichiro Sonoda; Yoshihiro Yasuda; Motohide Shimazu; Ayumu Sugiura; Shigeru Yanagi; Hitoshi Miura; Hiroyuki Uchino; Eskil Elmér
Minocycline sensitizes rodent and human liver mitochondria to the permeability transition: implications for toxicity in liver transplantation.
Hepatology (Baltimore, Md.) 2010;51(1):347-8; author reply 349-50.
2010: Magnus J Hansson; Saori Morota; Maria Teilum; Gustav Mattiasson; Hiroyuki Uchino; Eskil Elmér
Increased potassium conductance of brain mitochondria induces resistance to permeability transition by enhancing matrix volume.
The Journal of biological chemistry 2010;285(1):741-50.
2009: Saori Morota; Roland Månsson; Magnus J Hansson; Kazuhiko Kasuya; Motohide Shimazu; Erika Hasegawa; Shigeru Yanagi; Akibumi Omi; Hiroyuki Uchino; Eskil Elmér
Evaluation of putative inhibitors of mitochondrial permeability transition for brain disorders--specificity vs. toxicity.
Experimental neurology 2009;218(2):353-62.
2008: Magnus J Hansson; Roland Månsson; Saori Morota; Hiroyuki Uchino; Thérese Kallur; Tetsuo Sumi; Nagao Ishii; Motohide Shimazu; Marcus F Keep; Alexandr Jegorov; Eskil Elmér
Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition.
Free radical biology & medicine 2008;45(3):284-94.
2008: Hiroyuki Uchino; Yasuhiro Kuroda; Saori Morota; Go Hirabayashi; Nagao Ishii; Futoshi Shibasaki; Yukiho Ikeda; Magnus J Hansson; Eskil Elmér
Probing the molecular mechanisms of neuronal degeneration: importance of mitochondrial dysfunction and calcineurin activation.
Journal of anesthesia 2008;22(3):253-62.
2007: Saori Morota; Magnus J Hansson; Nagao Ishii; Yoshihisa Kudo; Eskil Elmér; Hiroyuki Uchino
Spinal cord mitochondria display lower calcium retention capacity compared with brain mitochondria without inherent differences in sensitivity to cyclophilin D inhibition.
Journal of neurochemistry 2007;103(5):2066-76.
2007: Roland Månsson; Magnus J Hansson; Saori Morota; Hiroyuki Uchino; Christine T Ekdahl Clementson; Eskil Elmér
Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline.
Neurobiology of disease 2007;25(1):198-205.
2006: Maria Teilum; Magnus J Hansson; M B Dainiak; Roland Månsson; S Surve; Eskil Elmér; P Onnerfjord; Gustav Mattiasson
Binding mitochondria to cryogel monoliths allows detection of proteins specifically released following permeability transition.
Analytical biochemistry 2006;348(2):209-21.
2006: Mattias Rickhag; Tadeusz Wieloch; Gunilla Gidö; Eskil Elmér; Morten Krogh; Joseph Murray; Scott Lohr; Hans Bitter; Daniel J Chin; David von Schack; Mehrdad Shamloo; Karoly Nikolich
Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia-induced gene expression patterns, and reveals a biphasic activation of genes in surviving tissue.
Journal of neurochemistry 2006;96(1):14-29.
2005: Anna Rytter; Carla M P Cardoso; Petra Johansson; Tobias Cronberg; Magnus J Hansson; Gustav Mattiasson; Eskil Elmér; Tadeusz Wieloch
The temperature dependence and involvement of mitochondria permeability transition and caspase activation in damage to organotypic hippocampal slices following in vitro ischemia.
Journal of neurochemistry 2005;95(4):1108-17.
2004: Magnus J Hansson; Gustav Mattiasson; Roland Månsson; Jenny Karlsson; Marcus F Keep; Peter Waldmeier; Urs T Ruegg; Jean-Maurice Dumont; Kamel Besseghir; Eskil Elmér
The nonimmunosuppressive cyclosporin analogs NIM811 and UNIL025 display nanomolar potencies on permeability transition in brain-derived mitochondria.
Journal of bioenergetics and biomembranes 2004;36(4):407-13.
2004: Jenny Karlsson; Keith Fong; Magnus J Hansson; Eskil Elmér; Katalin Csiszar; Marcus F Keep
Life span extension and reduced neuronal death after weekly intraventricular cyclosporin injections in the G93A transgenic mouse model of amyotrophic lateral sclerosis.
Journal of neurosurgery 2004;101(1):128-37.
2004: Magnus J Hansson; Roland Månsson; Gustav Mattiasson; Jonas Ohlsson; Jenny Karlsson; Marcus F Keep; Eskil Elmér
Brain-derived respiring mitochondria exhibit homogeneous, complete and cyclosporin-sensitive permeability transition.
Journal of neurochemistry 2004;89(3):715-29.
2003: Gustav Mattiasson; Hans Friberg; Magnus Hansson; Eskil Elmér; Tadeusz Wieloch
Flow cytometric analysis of mitochondria from CA1 and CA3 regions of rat hippocampus reveals differences in permeability transition pore activation.
Journal of neurochemistry 2003;87(2):532-44.
2003: Dong Liu; John R Slevin; Chengbiao Lu; Sic L Chan; Magnus Hansson; Eskil Elmér; Mark P Mattson
Involvement of mitochondrial K+ release and cellular efflux in ischemic and apoptotic neuronal death.
Journal of neurochemistry 2003;86(4):966-79.
2003: Magnus J Hansson; Tanja Persson; Hans Friberg; Marcus F Keep; Anthony Rees; Tadeusz Wieloch; Eskil Elmér
Powerful cyclosporin inhibition of calcium-induced permeability transition in brain mitochondria.
Brain research 2003;960(1-2):99-111.
2001: Christine T Ekdahl Clementson; Paul Mohapel; Eskil Elmér; Olle Lindvall
Caspase inhibitors increase short-term survival of progenitor-cell progeny in the adult rat dentate gyrus following status epilepticus.
The European journal of neuroscience 2001;14(6):937-45.
2001: Marcus F Keep; Eskil Elmér; Keith Fong; Katalin Csiszar
Intrathecal cyclosporin prolongs survival of late-stage ALS mice.
Brain research 2001;894(2):327-31.
2000: Cesario Borlongan; Christine E Stahl; Marcus F Keep; Eskil Elmér; S Watanabe
Cyclosporine-A enhances choline acetyltransferase immunoreactivity in the septal region of adult rats.
Neuroscience letters 2000;279(2):73-6.
1999: Bo K Siesjö; Eskil Elmér; Shorena Janelidze; Marcus F Keep; Tibor Kristián; Yi Bing Ouyang; Hiroyuki Uchino
Role and mechanisms of secondary mitochondrial failure.
Acta neurochirurgica. Supplement 1999;73():7-13.
1998: Hiroyuki Uchino; Eskil Elmér; K Uchino; Ping-An Li; Qing-Ping He; M L Smith; Bo K Siesjö
Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat.
Brain research 1998;812(1-2):216-26.
1998: Eskil Elmér; Merab Kokaia; Zaal Kokaia; D C McIntyre; Olle Lindvall
Epileptogenesis induced by rapidly recurring seizures in genetically fast- but not slow-kindling rats.
Brain research 1998;789(1):111-7.
1998: Eskil Elmér; Zaal Kokaia; Merab Kokaia; J Carnahan; H Nawa; Olle Lindvall
Dynamic changes of brain-derived neurotrophic factor protein levels in the rat forebrain after single and recurring kindling-induced seizures.
Neuroscience 1998;83(2):351-62.
1998: I Ferencz; Merab Kokaia; Eskil Elmér; Marcus F Keep; Zaal Kokaia; Olle Lindvall
Suppression of kindling epileptogenesis in rats by intrahippocampal cholinergic grafts.
The European journal of neuroscience 1998;10(1):213-20.
1997: Johan Bengzon; Zaal Kokaia; Eskil Elmér; Avtandil Nanobashvili; Merab Kokaia; Olle Lindvall
Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10432-7.
1997: I Ferencz; Merab Kokaia; Marcus F Keep; Eskil Elmér; M Metsis; Zaal Kokaia; Olle Lindvall
Effects of cholinergic denervation on seizure development and neurotrophin messenger RNA regulation in rapid hippocampal kindling.
Neuroscience 1997;80(2):389-99.
1997: Eskil Elmér; Merab Kokaia; Patrik Ernfors; I Ferencz; Zaal Kokaia; Olle Lindvall
Suppressed kindling epileptogenesis and perturbed BDNF and TrkB gene regulation in NT-3 mutant mice.
Experimental neurology 1997;145(1):93-103.
1997: Ping-An Li; Hiroyuki Uchino; Eskil Elmér; Bo K Siesjö
Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia.
Brain research 1997;753(1):133-40.
1997: Eskil Elmér; Zaal Kokaia; Merab Kokaia; Olle Lindvall; D C McIntyre
Mossy fibre sprouting: evidence against a facilitatory role in epileptogenesis.
Neuroreport 1997;8(5):1193-6.
1996: Eskil Elmér; Per Alm; Zaal Kokaia; Merab Kokaia; Bengt Larsson; Marcus F Keep; Karl-Erik Andersson; Olle Lindvall
Regulation of neuronal nitric oxide synthase mRNA levels in rat brain by seizure activity.
Neuroreport 1996;7(7):1335-9.
1996: Zaal Kokaia; Hiroyuki Nawa; H Uchino; Eskil Elmér; Merab Kokaia; J Carnahan; M L Smith; Bo K Siesjö; Olle Lindvall
Regional brain-derived neurotrophic factor mRNA and protein levels following transient forebrain ischemia in the rat.
Brain research. Molecular brain research 1996;38(1):139-44.
1996: Eskil Elmér; Merab Kokaia; Zaal Kokaia; I Ferencz; Olle Lindvall
Delayed kindling development after rapidly recurring seizures: relation to mossy fiber sprouting and neurotrophin, GAP-43 and dynorphin gene expression.
Brain research 1996;712(1):19-34.
1996: Merab Kokaia; I Ferencz; G Leanza; Eskil Elmér; M Metsis; Zaal Kokaia; R G Wiley; Olle Lindvall
Immunolesioning of basal forebrain cholinergic neurons facilitates hippocampal kindling and perturbs neurotrophin messenger RNA regulation.
Neuroscience 1996;70(2):313-27.
1996: Olle Lindvall; Zaal Kokaia; Johan Bengzon; Eskil Elmér; Merab Kokaia
Expression of neurotrophin mRNAs in the postischemic phase.
Advances in neurology 1996;71():405-11.
1995: H Uchino; Eskil Elmér; K Uchino; Olle Lindvall; Bo K Siesjö
Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischaemia in the rat.
Acta physiologica Scandinavica 1995;155(4):469-71.
1995: Zaal Kokaia; Q Zhao; Merab Kokaia; Eskil Elmér; M Metsis; M L Smith; Bo K Siesjö; Olle Lindvall
Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage.
Experimental neurology 1995;136(1):73-88.
1995: Merab Kokaia; Patrik Ernfors; Zaal Kokaia; Eskil Elmér; Rudolf Jaenisch; Olle Lindvall
Suppressed epileptogenesis in BDNF mutant mice.
Experimental neurology 1995;133(2):215-24.
1995: Zaal Kokaia; M Metsis; Merab Kokaia; Eskil Elmér; Olle Lindvall
Co-expression of TrkB and TrkC receptors in CNS neurones suggests regulation by multiple neurotrophins.
Neuroreport 1995;6(5):769-72.
1994: Merab Kokaia; M A Cenci; Eskil Elmér; O G Nilsson; Zaal Kokaia; Johan Bengzon; Anders Björklund; Olle Lindvall
Seizure development and noradrenaline release in kindling epilepsy after noradrenergic reinnervation of the subcortically deafferented hippocampus by superior cervical ganglion or fetal locus coeruleus grafts.
Experimental neurology 1994;130(2):351-61.
1994: Olle Lindvall; Zaal Kokaia; Johan Bengzon; Eskil Elmér; Merab Kokaia
Neurotrophins and brain insults.
Trends in neurosciences 1994;17(11):490-6.
1994: Merab Kokaia; G D Pratt; Eskil Elmér; Johan Bengzon; J M Fritschy; Zaal Kokaia; Olle Lindvall; H Mohler
Biphasic differential changes of GABAA receptor subunit mRNA levels in dentate gyrus granule cells following recurrent kindling-induced seizures.
Brain research. Molecular brain research 1994;23(4):323-32.
1994: Zaal Kokaia; M Metsis; Merab Kokaia; Johan Bengzon; Eskil Elmér; M L Smith; Tõnis Timmusk; B K Siesjö; H Persson; Olle Lindvall
Brain insults in rats induce increased expression of the BDNF gene through differential use of multiple promoters.
The European journal of neuroscience 1994;6(4):587-96.
1994: Merab Kokaia; P Aebischer; Eskil Elmér; Johan Bengzon; P Kalén; Zaal Kokaia; Olle Lindvall
Seizure suppression in kindling epilepsy by intracerebral implants of GABA- but not by noradrenaline-releasing polymer matrices.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1994;100(3):385-94.