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Mikael Elofsson

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TOP 3
Mårten Strand; Annika Allard; Tomas Bergström; Karin Edlund; Mikael Elofsson; Koushikul Islam; Ya-Fang Mei; Christopher T Oberg; Göran Wadell
2-[4,5-Difluoro-2-(2-fluorobenzoylamino)-benzoylamino]benzoic acid, an antiviral compound with activity against acyclovir-resistant isolates of herpes simplex virus types 1 and 2.
Donald N Forthal; Gary Landucci; Hencelyn Chu; Mikael Elofsson; Tran B Phan; Anatoly V Slepenkin; Ellena Peterson
In vitro anti-HIV-1 activity of salicylidene acylhydrazide compounds.
C David Andersson; Torun Ekblad; Mikael Elofsson; Tobias Karlberg; Anders E G Lindgren; Moritz S Niemiec; Herwig Schüler; Sara Spjut; Ann-Gerd Thorsell; Urszula Uciechowska; Johan Weigelt; Pernilla Wittung-Stafshede; Anna Linusson
Discovery of ligands for ADP-ribosyltransferases via docking-based virtual screening.

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All Publications

2012: Mårten Strand; Annika Allard; Tomas Bergström; Karin Edlund; Mikael Elofsson; Koushikul Islam; Ya-Fang Mei; Christopher T Oberg; Göran Wadell
2-[4,5-Difluoro-2-(2-fluorobenzoylamino)-benzoylamino]benzoic acid, an antiviral compound with activity against acyclovir-resistant isolates of herpes simplex virus types 1 and 2.
Antimicrobial agents and chemotherapy 2012;56(11):5735-43.
2012: Donald N Forthal; Gary Landucci; Hencelyn Chu; Mikael Elofsson; Tran B Phan; Anatoly V Slepenkin; Ellena Peterson
In vitro anti-HIV-1 activity of salicylidene acylhydrazide compounds.
International journal of antimicrobial agents 2012;40(4):354-60.
2012: C David Andersson; Torun Ekblad; Mikael Elofsson; Tobias Karlberg; Anders E G Lindgren; Moritz S Niemiec; Herwig Schüler; Sara Spjut; Ann-Gerd Thorsell; Urszula Uciechowska; Johan Weigelt; Pernilla Wittung-Stafshede; Anna Linusson
Discovery of ligands for ADP-ribosyltransferases via docking-based virtual screening.
Journal of medicinal chemistry 2012;55(17):7706-18.
2012: Tofeeq Ur-Rehman; Caroline E Zetterström; Ellena M Peterson; Anatoly Slepenkin; Anders Blomgren; Hencelyn Chu; Markus K Dahlgren; Mikael Elofsson; Asa Gylfe
Pre-clinical pharmacokinetics and anti-chlamydial activity of salicylidene acylhydrazide inhibitors of bacterial type III secretion.
The Journal of antibiotics 2012;65(8):397-404.
2012: Per-Anders Enquist; Asa Gylfe; Ulrik Hägglund; Pia Lindström; Henrik Norberg-Scherman; Charlotta Sundin; Mikael Elofsson
Derivatives of 8-hydroxyquinoline--antibacterial agents that target intra- and extracellular Gram-negative pathogens.
Bioorganic & medicinal chemistry letters 2012;22(10):3550-3.
2012: Christopher T Öberg; Emma K Andersson; Karin Edlund; Ya-Fang Mei; Mårten Strand; Nam Phuong Nguyen Tran; Göran Wadell; Mikael Elofsson
Synthesis, biological evaluation, and structure-activity relationships of 2-[2-(benzoylamino)benzoylamino]benzoic acid analogues as inhibitors of adenovirus replication.
Journal of medicinal chemistry 2012;55(7):3170-81.
2012: J Mikael Hillgren; Christopher T Oberg; Mikael Elofsson
Syntheses of pseudoceramines A-D and a new synthesis of spermatinamine, bromotyrosine natural products from marine sponges.
Organic & biomolecular chemistry 2012;10(6):1246-54.
2012: Jonas Eriksson; Christin Grundström; Uwe H Sauer; A Elisabeth Sauer-Eriksson; Hans Wolf-Watz; Mikael Elofsson
Small molecule screening for inhibitors of the YopH phosphatase of Yersinia pseudotuberculosis.
Advances in experimental medicine and biology 2012;954():357-63.
2012: Tofeeq Ur-Rehman; Caroline E Zetterström; Anders Blomgren; Mikael Elofsson; Roland Nordfelth; Asa Gylfe
Preliminary pharmacokinetics of the bacterial virulence inhibitor n'-(3,5-dibromo-2-hydroxy-benzylidenene)-nicotinic Acid hydrazide.
Advances in experimental medicine and biology 2012;954():349-56.
2012: Mads Gabrielsen; Sylke Müller; Dai Wang; Caroline E Zetterström; Rommie E Amaro; Katherine S H Beckham; Olwyn Byron; Mikael Elofsson; Victoria A Feher; Andrew J Roe
Structural characterisation of Tpx from Yersinia pseudotuberculosis reveals insights into the binding of salicylidene acylhydrazide compounds.
PloS one 2012;7(2):e32217.
2011: Anatoly Slepenkin; Hencelyn Chu; Mikael Elofsson; Pia Keyser; Ellena M Peterson
Protection of mice from a Chlamydia trachomatis vaginal infection using a Salicylidene acylhydrazide, a potential microbicide.
The Journal of infectious diseases 2011;204(9):1313-20.
2011: Sheng Yin; Todd Shelper; Charlotta Sundin; Melissa L Sykes; Vicky M Avery; Rohan A Davis; Mikael Elofsson; Ronald J Quinn
Pseudoceramines A-D, new antibacterial bromotyrosine alkaloids from the marine sponge Pseudoceratina sp.
Organic & biomolecular chemistry 2011;9(19):6755-60.
2011: Dai Wang; Caroline E Zetterström; Brian O Smith; Jai J Tree; Hanna Uvell; Katherine S H Beckham; Richard Burchmore; Olwyn Byron; Mikael Elofsson; Mads Gabrielsen; David L Gally; Pawel Herzyk; Sarah E Macdonald; Arvind Mahajan; Tim J Mitchell; Andrew J Roe
Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds.
The Journal of biological chemistry 2011;286(34):29922-31.
2011: Sara Spjut; Thilo Stehle; Rickard Storm; Niklas Arnberg; Johannes Bauer; Lars Frängsmyr; Weixing Qian; Mikael Elofsson
A potent trivalent sialic acid inhibitor of adenovirus type 37 infection of human corneal cells.
Angewandte Chemie (International ed. in English) 2011;50(29):6519-21.
2010: Mads Gabrielsen; Caroline E Zetterström; Dai Wang; Katherine S H Beckham; Mikael Elofsson; Neil W Isaacs; Andrew J Roe
Expression, purification, crystallization and initial X-ray diffraction analysis of thiol peroxidase from Yersinia pseudotuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 12):1606-9.
2010: J Mikael Hillgren; Markus K Dahlgren; Tam M To; Mikael Elofsson
Synthesis of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones as potential bioisosteres of salicylidene acylhydrazides.
Molecules (Basel, Switzerland) 2010;15(9):6019-34.
2010: Emma K Andersson; Mårten Strand; Karin Edlund; Kristina Lindman; Per-Anders Enquist; Sara Spjut; Annika Allard; Mikael Elofsson; Ya-Fang Mei; Göran Wadell
Small-molecule screening using a whole-cell viral replication reporter gene assay identifies 2-{[2-(benzoylamino)benzoyl]amino}-benzoic acid as a novel antiadenoviral compound.
Antimicrobial agents and chemotherapy 2010;54(9):3871-7.
2010: Sara Spjut; Weixing Qian; Mikael Elofsson
Synthesis and application of a 2-[(4-fluorophenyl)-sulfonyl]ethoxy carbonyl(Fsec) protected glycosyl donor in carbohydrate chemistry.
Molecules (Basel, Switzerland) 2010;15(8):5708-20.
2010: Hencelyn Chu; Anatoly Slepenkin; Mikael Elofsson; Pia Keyser; Luis M de la Maza; Ellena M Peterson
Candidate vaginal microbicides with activity against Chlamydia trachomatis and Neisseriagonorrhoeae.
International journal of antimicrobial agents 2010;36(2):145-50.
2010: Markus K Dahlgren; Christopher T Oberg; Erika A Wallin; Pär G Janson; Mikael Elofsson
Synthesis of 2-(2-aminopyrimidine)-2,2-difluoroethanols as potential bioisosters of salicylidene acylhydrazides.
Molecules (Basel, Switzerland) 2010;15(6):4423-38.
2010: Markus K Dahlgren; Caroline E Zetterström; Sa Gylfe; Anna Linusson; Mikael Elofsson
Statistical molecular design of a focused salicylidene acylhydrazide library and multivariate QSAR of inhibition of type III secretion in the Gram-negative bacterium Yersinia.
Bioorganic & medicinal chemistry 2010;18(7):2686-703.
2010: Anna Linusson; Mikael Elofsson; I E Andersson; M K Dahlgren
Statistical molecular design of balanced compound libraries for QSAR modeling.
Current medicinal chemistry 2010;17(19):2001-16.
2009: Susanne Johansson; Emma Nilsson; Weixing Qian; Delphine Guilligay; Thibaut Crépin; Stephen Cusack; Niklas Arnberg; Mikael Elofsson
Design, synthesis, and evaluation of N-acyl modified sialic acids as inhibitors of adenoviruses causing epidemic keratoconjunctivitis.
Journal of medicinal chemistry 2009;52(12):3666-78.
2009: Maciej Pudelko; Weixing Qian; Mikael Elofsson
Synthesis and application of N-[1-(4-(4-fluorophenyl)-2,6-dioxocyclohexylidene)ethyl] (Fde)-protected amino acids for optimization of solid-phase peptide synthesis using gel-phase (19)F NMR spectroscopy.
Journal of peptide science : an official publication of the European Peptide Society 2009;15(4):264-71.
2007: Markus K Dahlgren; Anna M Kauppi; Ing-Marie Olsson; Anna Linusson; Mikael Elofsson
Design, synthesis, and multivariate quantitative structure-activity relationship of salicylanilides--potent inhibitors of type III secretion in Yersinia.
Journal of medicinal chemistry 2007;50(24):6177-88.
2007: Anna M Kauppi; C David Andersson; Henrik A Norberg; Charlotta Sundin; Anna Linusson; Mikael Elofsson
Inhibitors of type III secretion in Yersinia: design, synthesis and multivariate QSAR of 2-arylsulfonylamino-benzanilides.
Bioorganic & medicinal chemistry 2007;15(22):6994-7011.
2007: Fredrik Wallner; Sara Spjut; Dan Boström; Mikael Elofsson
Synthesis and evaluation of 2-(2-fluoro-4-hydroxymethyl-5-methoxy-phenoxy)acetic acid as a linker in solid-phase synthesis monitored by gel-phase (19)F NMR spectroscopy.
Organic & biomolecular chemistry 2007;5(15):2464-71.
2007: Aurel Negrea; Eva Bjur; Sofia Eriksson Ygberg; Mikael Elofsson; Hans Wolf-Watz; Mikael Rhen
Salicylidene acylhydrazides that affect type III protein secretion in Salmonella enterica serovar typhimurium.
Antimicrobial agents and chemotherapy 2007;51(8):2867-76.
2007: Debra L Hudson; Abigail N Layton; Terry R Field; Alison J Bowen; Hans Wolf-Watz; Mikael Elofsson; Mark P Stevens; Edouard E Galyov
Inhibition of type III secretion in Salmonella enterica serovar Typhimurium by small-molecule inhibitors.
Antimicrobial agents and chemotherapy 2007;51(7):2631-5.
2007: Anatoly Slepenkin; Per-Anders Enquist; Ulrik Hägglund; Luis M de la Maza; Mikael Elofsson; Ellena M Peterson
Reversal of the antichlamydial activity of putative type III secretion inhibitors by iron.
Infection and immunity 2007;75(7):3478-89.
2007: Maciej Pudelko; Jan Kihlberg; Mikael Elofsson
Application of gel-phase 19F NMR spectroscopy for optimization of solid-phase synthesis of a hydrophobic peptide from the signal sequence of the mucin MUC1.
Journal of peptide science : an official publication of the European Peptide Society 2007;13(5):354-61.
2007: Leslie Bailey; Asa Gylfe; Charlotta Sundin; Sandra Muschiol; Mikael Elofsson; Peter Nordström; Birgitta Henriques Normark; Raimond Lugert; Anders Waldenström; Hans Wolf-Watz; Sven Bergström
Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle.
FEBS letters 2007;581(4):587-95.
2007: Susanne M C Johansson; Emma C Nilsson; Mikael Elofsson; Nina Ahlskog; Jan Kihlberg; Niklas Arnberg
Multivalent sialic acid conjugates inhibit adenovirus type 37 from binding to and infecting human corneal epithelial cells.
Antiviral research 2007;73(2):92-100.
2006: Sandra Muschiol; Leslie Bailey; Asa Gylfe; Charlotta Sundin; Kjell Hultenby; Sven Bergström; Mikael Elofsson; Hans Wolf-Watz; Staffan Normark; Birgitta Henriques Normark
A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14566-71.
2006: Fredrik Wallner; Mikael Elofsson
NMR tube filter reactor for solid-phase synthesis and gel-phase 19F NMR spectroscopy.
Journal of combinatorial chemistry 2006;8(2):150-2.
2006: Maciej Pudelko; Anna Lindgren; Tobias Tengel; Celso A Reis; Mikael Elofsson; Jan Kihlberg
Formation of lactones from sialylated MUC1 glycopeptides.
Organic & biomolecular chemistry 2006;4(4):713-20.
2005: Roland Nordfelth; Anna M Kauppi; Henrik A Norberg; Hans Wolf-Watz; Mikael Elofsson
Small-molecule inhibitors specifically targeting type III secretion.
Infection and immunity 2005;73(5):3104-14.
2005: Susanne M C Johansson; Niklas Arnberg; Mikael Elofsson; Göran Wadell; Jan Kihlberg
Multivalent HSA conjugates of 3'-sialyllactose are potent inhibitors of adenoviral cell attachment and infection.
Chembiochem : a European journal of chemical biology 2005;6(2):358-64.
2005: Fredrik Wallner; Henrik A Norberg; Annika I Johansson; Mickael Mogemark; Mikael Elofsson
Solid-phase synthesis of serine-based glycosphingolipid analogues for preparation of glycoconjugate arrays.
Organic & biomolecular chemistry 2005;3(2):309-15.
2004: Mickael Mogemark; Linda Gustafsson; Christoffer Bengtsson; Mikael Elofsson; Jan Kihlberg
A fluorinated selenide linker for solid-phase synthesis of n-pentenyl glycosides.
Organic letters 2004;6(26):4885-8.
2004: Mickael Mogemark; Frida Gårdmo; Tobias Tengel; Jan Kihlberg; Mikael Elofsson
Gel-phase 19F NMR spectral quality for resins commonly used in solid-phase organic synthesis; a study of peptide solid-phase glycosylations.
Organic & biomolecular chemistry 2004;2(12):1770-6.
2004: Fredrik Wallner; Liying Chen; Annalena Moliner; Mikael Jondal; Mikael Elofsson
Loading of the antigen-presenting protein CD1d with synthetic glycolipids.
Chembiochem : a European journal of chemical biology 2004;5(4):437-44.
2003: Mickael Mogemark; Mikael Elofsson; Jan Kihlberg
Solid-phase synthesis of alpha-Gal epitopes: on-resin analysis of solid-phase oligosaccharide synthesis with 19F NMR spectroscopy.
The Journal of organic chemistry 2003;68(19):7281-8.
2003: Anna M Kauppi; Roland Nordfelth; Hanna Uvell; Hans Wolf-Watz; Mikael Elofsson
Targeting bacterial virulence: inhibitors of type III secretion in Yersinia.
Chemistry & biology 2003;10(3):241-9.
2003: Anna M Kauppi; Roland Nordfelth; Ulrik Hägglund; Hans Wolf-Watz; Mikael Elofsson
Salicylanilides are potent inhibitors of type III secretion in Yersinia.
Advances in experimental medicine and biology 2003;529():97-100.
2002: Mickael Mogemark; Mikael Elofsson; Jan Kihlberg
Fluorinated protective groups for on-resin quantification of solid-phase oligosaccharide synthesis with 19F NMR spectroscopy.
Chembiochem : a European journal of chemical biology 2002;3(12):1266-9.
2001: Mickael Mogemark; Mikael Elofsson; Jan Kihlberg
Monitoring solid-phase glycoside synthesis with (19)F NMR spectroscopy.
Organic letters 2001;3(10):1463-6.
1997: Jan Kihlberg; Mikael Elofsson; L A Salvador
Direct synthesis of glycosylated amino acids from carbohydrate peracetates and Fmoc amino acids: solid-phase synthesis of biomedicinally interesting glycopeptides.
Methods in enzymology 1997;289():221-45.