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Orna Elroy-Stein

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Physiology

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Mouse

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Down's Syndrome

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Yuval Cabilly; David Chetrit; Marcelo Ehrlich; Michal Geva; Liraz Marom; Mali Barbi; Orna Elroy-Stein
Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease.
Sima Barhoom; Barry S Cooperman; Marcelo Ehrlich; Jaskiran Kaur; Zeev Smilansky; Nechama I Smorodinsky; Orna Elroy-Stein
Quantitative single cell monitoring of protein synthesis at subcellular resolution using fluorescently labeled tRNA.
Gilad Sivan; Ranen Aviner; Orna Elroy-Stein
Mitotic modulation of translation elongation factor 1 leads to hindered tRNA delivery to ribosomes.

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2012: Yuval Cabilly; David Chetrit; Marcelo Ehrlich; Michal Geva; Liraz Marom; Mali Barbi; Orna Elroy-Stein
Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease.
PloS one 2012;7(10):e46715.
2011: Sima Barhoom; Barry S Cooperman; Marcelo Ehrlich; Jaskiran Kaur; Zeev Smilansky; Nechama I Smorodinsky; Orna Elroy-Stein
Quantitative single cell monitoring of protein synthesis at subcellular resolution using fluorescently labeled tRNA.
Nucleic acids research 2011;39(19):e129.
2011: Gilad Sivan; Ranen Aviner; Orna Elroy-Stein
Mitotic modulation of translation elongation factor 1 leads to hindered tRNA delivery to ribosomes.
The Journal of biological chemistry 2011;286(32):27927-35.
2011: Eyal Mor; Yuval Cabilly; Yona Goldshmit; Harel Zalts; Shira Modai; Liat Edry; Orna Elroy-Stein; Noam Shomron
Species-specific microRNA roles elucidated following astrocyte activation.
Nucleic acids research 2011;39(9):3710-23.
2011: Liraz Marom; Ron Shamir; Igor Ulitsky; Yuval Cabilly; Orna Elroy-Stein
A point mutation in translation initiation factor eIF2B leads to function--and time-specific changes in brain gene expression.
PloS one 2011;6(10):e26992.
2010: Michal Geva; Yuval Cabilly; Yaniv Assaf; Nina Mindroul; Liraz Marom; Gali Raini; Dalia Pinchasi; Orna Elroy-Stein
A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter.
Brain : a journal of neurology 2010;133(Pt 8):2448-61.
2010: Laetitia Horzinski; Liraz Kantor; Aurélia Huyghe; Raphael Schiffmann; Orna Elroy-Stein; Odile Boespflug-Tanguy; Anne Fogli
Evaluation of the endoplasmic reticulum-stress response in eIF2B-mutated lymphocytes and lymphoblasts from CACH/VWM patients.
BMC neurology 2010;10():94.
2009: Hadas Raveh-Amit; Adva Maissel; Jonathan Poller; Liraz Marom; Orna Elroy-Stein; Michal Shapira; Etta Livneh
Translational control of protein kinase Ceta by two upstream open reading frames.
Molecular and cellular biology 2009;29(22):6140-8.
2009: Liraz Marom; Shelly Hen-Avivi; Dalia Pinchasi; Julia A Chekanova; Dmitry A Belostotsky; Orna Elroy-Stein
Diverse poly(A) binding proteins mediate internal translational initiation by a plant viral IRES.
RNA biology 2009;6(4):446-54.
2008: Lea Marash; Noa Liberman; Sivan Henis-Korenblit; Gilad Sivan; Eran Reem; Orna Elroy-Stein; Adi Kimchi
DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis.
Molecular cell 2008;30(4):447-59.
2008: Gilad Sivan; Orna Elroy-Stein
Regulation of mRNA Translation during cellular division.
Cell cycle (Georgetown, Tex.) 2008;7(6):741-4.
2008: Liraz Kantor; Dalia Pinchasi; Michelle Mintz; Yetrib Hathout; Adeline Vanderver; Orna Elroy-Stein
A point mutation in translation initiation factor 2B leads to a continuous hyper stress state in oligodendroglial-derived cells.
PloS one 2008;3(11):e3783.
2007: Gilad Sivan; Nancy Kedersha; Orna Elroy-Stein
Ribosomal slowdown mediates translational arrest during cellular division.
Molecular and cellular biology 2007;27(19):6639-46.
2006: Deborah Silvera; Nadejda Koloteva-Levine; Sandeep Burma; Orna Elroy-Stein
Effect of Ku proteins on IRES-mediated translation.
Biology of the cell / under the auspices of the European Cell Biology Organization 2006;98(6):353-61.
2006: Raphael Schiffmann; Orna Elroy-Stein
Childhood ataxia with CNS hypomyelination/vanishing white matter disease--a common leukodystrophy caused by abnormal control of protein synthesis.
Molecular genetics and metabolism 2006;88(1):7-15.
2005: Liraz Kantor; Heather P Harding; David Ron; Raphael Schiffmann; Christine R Kaneski; Scot R Kimball; Orna Elroy-Stein
Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients.
Human genetics 2005;118(1):99-106.
2005: Dvir Dahary; Orna Elroy-Stein; Rotem Sorek
Naturally occurring antisense: transcriptional leakage or real overlap?
Genome research 2005;15(3):364-8.
2004: Nadejda Koloteva-Levine; Dalia Pinchasi; Idan Pereman; Amit Zur; Michael Brandeis; Orna Elroy-Stein
The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation.
Molecular and cellular biology 2004;24(9):3577-87.
2002: Nadejda Koloteva-Levine; Maya Amichay; Orna Elroy-Stein
Interaction of hnRNP-C1/C2 proteins with RNA: analysis using the yeast three-hybrid system.
FEBS letters 2002;523(1-3):73-8.
2002: Gabi Gerlitz; Rosemary Jagus; Orna Elroy-Stein
Phosphorylation of initiation factor-2 alpha is required for activation of internal translation initiation during cell differentiation.
European journal of biochemistry / FEBS 2002;269(11):2810-9.
2001: Orna Elroy-Stein; Bernard Moss
Gene expression using the vaccinia virus/ T7 RNA polymerase hybrid system.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Chapter 5():Unit5.15.
2001: Orna Elroy-Stein; Bernard Moss
Gene expression using the vaccinia virus/T7 RNA polymerase hybrid system.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 16():Unit16.19.
2000: Amir Pozner; Dalia Goldenberg; Varda Negreanu; SY Le; Orna Elroy-Stein; Ditsa Levanon; Yoram Groner
Transcription-coupled translation control of AML1/RUNX1 is mediated by cap- and internal ribosome entry site-dependent mechanisms.
Molecular and cellular biology 2000;20(7):2297-307.
1999: Y Finkelstein; O Faktor; Orna Elroy-Stein; Ben-Zion Levi
The use of bi-cistronic transfer vectors for the baculovirus expression system.
Journal of biotechnology 1999;75(1):33-44.
1999: O Sella; Gabi Gerlitz; SY Le; Orna Elroy-Stein
Differentiation-induced internal translation of c-sis mRNA: analysis of the cis elements and their differentiation-linked binding to the hnRNP C protein.
Molecular and cellular biology 1999;19(8):5429-40.
1998: G Akiri; D Nahari; Y Finkelstein; SY Le; Orna Elroy-Stein; Ben-Zion Levi
Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription.
Oncogene 1998;17(2):227-36.
1998: Gabi Gerlitz; Orna Elroy-Stein
Does EBV RNA modulate ADA mRNA translation?
Leukemia 1998;12(2):249.
1997: Kinneret Savitsky; Matthias Platzer; Tamar Uziel; Susan Gilad; A Sartiel; André Rosenthal; Orna Elroy-Stein; Yosef Shiloh; Galit Rotman
Ataxia-telangiectasia: structural diversity of untranslated sequences suggests complex post-transcriptional regulation of ATM gene expression.
Nucleic acids research 1997;25(9):1678-84.
1997: Jeanne Bernstein; O Sella; SY Le; Orna Elroy-Stein
PDGF2/c-sis mRNA leader contains a differentiation-linked internal ribosomal entry site (D-IRES).
The Journal of biological chemistry 1997;272(14):9356-62.
1997: D Strauss; Orna Elroy-Stein; Rachel Ehrlich
Adenovirus E1a interferes with expression of vaccinia viral genes.
Gene 1997;184(2):279-84.
1996: Metsada Pasmanik-Chor; S Laadan; Orna Elroy-Stein; Ari Zimran; A Abrahamov; Shimon Gatt; Mia Horowitz
The glucocerebrosidase D409H mutation in Gaucher disease.
Biochemical and molecular medicine 1996;59(2):125-33.
1996: Metsada Pasmanik-Chor; Orna Elroy-Stein; johannes aerts; V Agmon; Shimon Gatt; Mia Horowitz
Overexpression of human glucocerebrosidase containing different-sized leaders.
The Biochemical journal 1996;317 ( Pt 1)():81-8.
1995: N Shterman; Orna Elroy-Stein; I Morad; M Amitsur; Gabriel Kaufmann
Cleavage of the HIV replication primer tRNALys,3 in human cells expressing bacterial anticodon nuclease.
Nucleic acids research 1995;23(10):1744-9.
1995: J Bernstein; Irit Shefler; Orna Elroy-Stein
The translational repression mediated by the platelet-derived growth factor 2/c-sis mRNA leader is relieved during megakaryocytic differentiation.
The Journal of biological chemistry 1995;270(18):10559-65.
1994: Sheila Zrihan-Licht; Amos Baruch; Orna Elroy-Stein; Iafa Keydar; Daniel H Wreschner
Tyrosine phosphorylation of the MUC1 breast cancer membrane proteins. Cytokine receptor-like molecules.
FEBS letters 1994;356(1):130-6.
1994: Sheila Zrihan-Licht; H L Vos; Amos Baruch; Orna Elroy-Stein; D Sagiv; Iafa Keydar; J Hilkens; Daniel H Wreschner
Characterization and molecular cloning of a novel MUC1 protein, devoid of tandem repeats, expressed in human breast cancer tissue.
European journal of biochemistry / FEBS 1994;224(2):787-95.
1994: Yoram Groner; Orna Elroy-Stein; Karen B Avraham; M Schickler; H Knobler; D Minc-Golomb; O Bar-Peled; R Yarom; Shlomo Rotshenker
Cell damage by excess CuZnSOD and Down's syndrome.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1994;48(5-6):231-40.
1990: Yoram Groner; Orna Elroy-Stein; Karen B Avraham; R Yarom; M Schickler; H Knobler; Galit Rotman
Down syndrome clinical symptoms are manifested in transfected cells and transgenic mice overexpressing the human Cu/Zn-superoxide dismutase gene.
Journal de physiologie 1990;84(1):53-77.
1989: M Schickler; H Knobler; Karen B Avraham; Orna Elroy-Stein; Yoram Groner
Diminished serotonin uptake in platelets of transgenic mice with increased Cu/Zn-superoxide dismutase activity.
The EMBO journal 1989;8(5):1385-92.
1988: Orna Elroy-Stein; Yoram Groner
Impaired neurotransmitter uptake in PC12 cells overexpressing human Cu/Zn-superoxide dismutase--implication for gene dosage effects in Down syndrome.
Cell 1988;52(2):259-67.
1987: Charles J Epstein; Karen B Avraham; Michael Lovett; S Smith; Orna Elroy-Stein; Galit Rotman; C Bry; Yoram Groner
Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(22):8044-8.
1987: Orna Elroy-Stein; Y Bernstein; Karen B Avraham; N Dafni; Ditsa Levanon; E Danciger; A Neer; Yoram Groner
Overexpression of the human CuZnSOD gene in transfected cells--implication to Down syndrome.
Progress in clinical and biological research 1987;253():373-92.
1986: Orna Elroy-Stein; Y Bernstein; Yoram Groner
Overproduction of human Cu/Zn-superoxide dismutase in transfected cells: extenuation of paraquat-mediated cytotoxicity and enhancement of lipid peroxidation.
The EMBO journal 1986;5(3):615-22.
1986: Yoram Groner; Orna Elroy-Stein; Y Bernstein; N Dafni; Ditsa Levanon; E Danciger; A Neer
Molecular genetics of Down's syndrome: overexpression of transfected human Cu/Zn-superoxide dismutase gene and the consequent physiological changes.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 1():381-93.
1985: Yoram Groner; J Lieman-Hurwitz; N Dafni; L Sherman; Ditsa Levanon; Y Bernstein; E Danciger; Orna Elroy-Stein
Molecular structure and expression of the gene locus on chromosome 21 encoding the Cu/Zn superoxide dismutase and its relevance to Down syndrome.
Annals of the New York Academy of Sciences 1985;450():133-56.