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Scott Ely

Research Profile

Chemicals & Drugs

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Plasma Cells

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Publications

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Xiangao Huang; David Jayabalan; Jun Liang; Tracey Louie; Malcolm A S Moore; Ruben Niesvizky; Sophia Randolph; Arthur L Shaffer; Louis M Staudt; Jamieson Bretz; Isan Chen; Maurizio Di Liberto; Scott Ely; William C Hahn; Selina Chen-Kiang
Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.
Shivakumar Subramaniyam; Pulivarthi H Rao; Scott Ely; Eric Feldman; Cory R Fraser; Susan Mathew
De novo B lymphoblastic leukemia/lymphoma in an adult with t(14;18)(q32;q21) and c-MYC gene rearrangement involving 10p13.
Jia Ruan; Peter Martin; Richard R Furman; Shing M Lee; Ken Cheung; Julie M Vose; Ann S LaCasce; Julia Morrison; Rebecca L Elstrom; Scott Ely; Amy Chadburn; Ethel Cesarman; Morton Coleman; John P Leonard
Bortezomib plus CHOP-rituximab for previously untreated diffuse large B-cell lymphoma and mantle cell lymphoma.

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All Publications

2012: Xiangao Huang; David Jayabalan; Jun Liang; Tracey Louie; Malcolm A S Moore; Ruben Niesvizky; Sophia Randolph; Arthur L Shaffer; Louis M Staudt; Jamieson Bretz; Isan Chen; Maurizio Di Liberto; Scott Ely; William C Hahn; Selina Chen-Kiang
Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.
Blood 2012;120(5):1095-106.
2011: Shivakumar Subramaniyam; Pulivarthi H Rao; Scott Ely; Eric Feldman; Cory R Fraser; Susan Mathew
De novo B lymphoblastic leukemia/lymphoma in an adult with t(14;18)(q32;q21) and c-MYC gene rearrangement involving 10p13.
Leukemia & lymphoma 2011;52(11):2195-9.
2011: Jia Ruan; Peter Martin; Richard R Furman; Shing M Lee; Ken Cheung; Julie M Vose; Ann S LaCasce; Julia Morrison; Rebecca L Elstrom; Scott Ely; Amy Chadburn; Ethel Cesarman; Morton Coleman; John P Leonard
Bortezomib plus CHOP-rituximab for previously untreated diffuse large B-cell lymphoma and mantle cell lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(6):690-7.
2009: Scott Ely
Personalized medicine: individualized care of cancer patients.
Translational research : the journal of laboratory and clinical medicine 2009;154(6):303-8.
2009: Peter Martin; Amy Chadburn; Paul J Christos; Karen Weil; Richard R Furman; Jia Ruan; Rebecca L Elstrom; Ruben Niesvizky; Scott Ely; Maurizio Diliberto; Ari Melnick; Daniel M Knowles; Selina Chen-Kiang; Morton Coleman; John P Leonard
Outcome of deferred initial therapy in mantle-cell lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(8):1209-13.
2008: Peter Martin; Amy Chadburn; Paul J Christos; Richard R Furman; J Ruan; M A Joyce; E Fusco; P Glynn; R Elstrom; Ruben Niesvizky; E J Feldman; Tsiporah Shore; Michael W Schuster; Scott Ely; Daniel M Knowles; S Chen-Kiang; Morton Coleman; John P Leonard
Intensive treatment strategies may not provide superior outcomes in mantle cell lymphoma: overall survival exceeding 7 years with standard therapies.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19(7):1327-30.
2008: Ruben Niesvizky; David S Jayabalan; Paul J Christos; Jessica R Furst; Tara Naib; Scott Ely; Jessica Jalbrzikowski; Roger Pearse; Faiza Zafar; Karen Pekle; April Larow; Richard Lent; Tomer Mark; Hearn J Cho; Tsiporah Shore; Jeffrey Tepler; John Harpel; Michael W Schuster; Susan Mathew; John P Leonard; Madhu Mazumdar; Selina Chen-Kiang; Morton Coleman
BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma.
Blood 2008;111(3):1101-9.
2007: Ruben Niesvizky; Tara Naib; Paul J Christos; David Jayabalan; Jessica R Furst; Jessica Jalbrzikowski; Faiza Zafar; Tomer Mark; Richard Lent; Roger Pearse; Scott Ely; John P Leonard; Madhu Mazumdar; Selina Chen-Kiang; Morton Coleman
Lenalidomide-induced myelosuppression is associated with renal dysfunction: adverse events evaluation of treatment-naïve patients undergoing front-line lenalidomide and dexamethasone therapy.
British journal of haematology 2007;138(5):640-3.
2006: Linda B. Baughn; Maurizio Di Liberto; Kaida Wu; Peter L Toogood; Tracey Louie; Rachel Gottschalk; Ruben Niesvizky; Hearn Cho; Scott Ely; Malcolm A S Moore; Selina Chen-Kiang
A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6.
Cancer research 2006;66(15):7661-7.
2005: Scott Ely; Maurizio Di Liberto; Ruben Niesvizky; Linda B. Baughn; Hearn J Cho; Eunice N Hatada; Daniel M Knowles; Joseph Lane; Selina Chen-Kiang
Mutually exclusive cyclin-dependent kinase 4/cyclin D1 and cyclin-dependent kinase 6/cyclin D2 pairing inactivates retinoblastoma protein and promotes cell cycle dysregulation in multiple myeloma.
Cancer research 2005;65(24):11345-53.
2005: Achim A Jungbluth; Scott Ely; Maurizio DiLiberto; Ruben Niesvizky; Barbara Williamson; Denise Frosina; Yao-Tseng Chen; Nina Bhardwaj; Selina Chen-Kiang; Lloyd J Old; Hearn Jay Cho
The cancer-testis antigens CT7 (MAGE-C1) and MAGE-A3/6 are commonly expressed in multiple myeloma and correlate with plasma-cell proliferation.
Blood 2005;106(1):167-74.
2004: Xiangao Huang; Maurizio Di Liberto; Adam F Cunningham; Lin Kang; Shuhua Cheng; Scott Ely; Hsiou-Chi Liou; Ian C M MacLennan; Selina Chen-Kiang
Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27Kip1.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(51):17789-94.
2003: John P Leonard; Morton Coleman; Jamie C Ketas; Amy Chadburn; Scott Ely; Richard R Furman; William A Wegener; Hans J Hansen; Heather Ziccardi; Michael Eschenberg; Urte Gayko; Alessandra Cesano; David M Goldenberg
Phase I/II trial of epratuzumab (humanized anti-CD22 antibody) in indolent non-Hodgkin's lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(16):3051-9.
2002: April Chiu; Langxing Pan; Zongdong Li; Scott Ely; Amy Chadburn; Daniel M Knowles
DNA polymerase mu gene expression in B-cell non-Hodgkin's lymphomas: an analysis utilizing in situ hybridization.
The American journal of pathology 2002;161(4):1349-55.
2002: Michelle R Tourigny; Josie Ursini-Siegel; Hayyoung Lee; Kai-Michael Toellner; Adam F Cunningham; David S Franklin; Scott Ely; Meihong Chen; Xiao-Feng Qin; Yue Xiong; Ian C M MacLennan; Selina Chen-Kiang
CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells.
Immunity 2002;17(2):179-89.
2002: Scott Ely; Daniel M Knowles
Expression of CD56/neural cell adhesion molecule correlates with the presence of lytic bone lesions in multiple myeloma and distinguishes myeloma from monoclonal gammopathy of undetermined significance and lymphomas with plasmacytoid differentiation.
The American journal of pathology 2002;160(4):1293-9.
2001: Scott Ely; A Werner; Amy Chadburn
An angiocentric orbital lesion with an immature natural killer cell immunophenotype.
Human pathology 2001;32(3):339-42.
2001: F Cerimele; Francesca Curreli; Scott Ely; Alvin E Friedman-Kien; Ethel Cesarman; Ornella Flore
Kaposi's sarcoma-associated herpesvirus can productively infect primary human keratinocytes and alter their growth properties.
Journal of virology 2001;75(5):2435-43.
2000: Scott Ely; Amy Chadburn; C M Dayton; Ethel Cesarman; Daniel M Knowles
Telomerase activity in B-cell non-Hodgkin lymphoma.
Cancer 2000;89(2):445-52.
1999: Scott Ely; J Powers; D Lewis; S Chang; A Rubio; J O'Leary; Daniel M Knowles
Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma arising in the subarachnoid space.
Human pathology 1999;30(8):981-4.
1998: Ornella Flore; Shahin Rafii; Scott Ely; John J O'Leary; Elizabeth Hyjek; Ethel Cesarman
Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus.
Nature 1998;394(6693):588-92.