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Sigurd Elz

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
27
Schunack, Walter
15
Pertz, Heinz
13
Stark, Holger
9
Schwartz, Jean-Charles
9
Seifert, Roland
9
Ganellin, Robin
9
Ligneau, Xavier
8
Buschauer, Armin
6
Dove, Stefan
6
Sasse, Astrid
4
Sellmer, Andreas
4
Schlicker, Eberhard
4
Sadek, Bassem
4
Arrang, Jean-Michel
4
Kiec-Kononowicz, Katarzyna

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Publications

TOP 3
Igel Patrick; Schneider Erich; Schnell David; Elz Sigurd; Seifert Roland; Buschauer Armin
N(G)-acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent.
Strasser Andrea; Wittmann Hans-Joachim; Kunze Marc; Elz Sigurd; Seifert Roland
Molecular basis for the selective interaction of synthetic agonists with the human histamine H1-receptor compared with the guinea pig H1-receptor.
Kraus Anja; Ghorai Prasanta; Birnkammer Tobias; Schnell David; Elz Sigurd; Seifert Roland; Dove Stefan; Bernhardt Günther; Buschauer Armin
N(G)-acylated aminothiazolylpropylguanidines as potent and selective histamine H(2) receptor agonists.

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All Publications

2009: Igel Patrick; Schneider Erich; Schnell David; Elz Sigurd; Seifert Roland; Buschauer Armin
N(G)-acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent.
Journal of medicinal chemistry 2009;52(8):2623-7.
2009: Strasser Andrea; Wittmann Hans-Joachim; Kunze Marc; Elz Sigurd; Seifert Roland
Molecular basis for the selective interaction of synthetic agonists with the human histamine H1-receptor compared with the guinea pig H1-receptor.
Molecular pharmacology 2009;75(3):454-65.
2009: Kraus Anja; Ghorai Prasanta; Birnkammer Tobias; Schnell David; Elz Sigurd; Seifert Roland; Dove Stefan; Bernhardt Günther; Buschauer Armin
N(G)-acylated aminothiazolylpropylguanidines as potent and selective histamine H(2) receptor agonists.
ChemMedChem 2009;4(2):232-40.
2008: Ghorai Prasanta; Kraus Anja; Keller Max; Götte Carsten; Igel Patrick; Schneider Erich; Schnell David; Bernhardt Günther; Dove Stefan; Zabel Manfred; Elz Sigurd; Seifert Roland; Buschauer Armin
Acylguanidines as bioisosteres of guanidines: NG-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists.
Journal of medicinal chemistry 2008;51(22):7193-204.
2008: Dove Stefan; Seifert Roland; Elz Sigurd; Buschauer Armin
Frontiers in medicinal chemistry in Regensburg.
ChemMedChem 2008;3(8):1181-4.
2008: Mahboobi Siavosh; Sellmer Andreas; Eswayah Asma; Elz Sigurd; Uecker Andrea; Böhmer Frank-D
Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides: a SAR study on the bioisosterism of pyrimidine and imidazole.
European journal of medicinal chemistry 2008;43(7):1444-53.
2007: Mahboobi Siavosh; Uecker Andrea; Cénac Christophe; Sellmer Andreas; Eichhorn Emerich; Elz Sigurd; Böhmer Frank-D; Dove Stefan
Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones.
Bioorganic & medicinal chemistry 2007;15(5):2187-97.
2006: Mahboobi Siavosh; Uecker Andrea; Sellmer Andreas; Cénac Christophe; Höcher Heymo; Pongratz Herwig; Eichhorn Emerich; Hufsky Harald; Trümpler Antje; Sicker Marit; Heidel Florian; Fischer Thomas; Stocking Carol; Elz Sigurd; Böhmer Frank-D; Dove Stefan
Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase.
Journal of medicinal chemistry 2006;49(11):3101-15.
2006: Xie Sheng-Xue; Kraus Anja; Ghorai Prasanta; Ye Qi-Zhuang; Elz Sigurd; Buschauer Armin; Seifert Roland
N1-(3-cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)propyl]guanidine (UR-AK57), a potent partial agonist for the human histamine H1- and H2-receptors.
The Journal of pharmacology and experimental therapeutics 2006;317(3):1262-8.
2006: Mahboobi Siavosh; Eichhorn Emerich; Popp Alfred; Sellmer Andreas; Elz Sigurd; Möllmann Ute
3-Bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives as new lead compounds for antibacterially active substances.
European journal of medicinal chemistry 2006;41(2):176-91.
2006: Patil Rameshwar; Elz Sigurd; Reiser Oliver
Side-chain modified analogues of histaprodifen: asymmetric synthesis and histamine H1-receptor activity.
Bioorganic & medicinal chemistry letters 2006;16(3):672-6.
2005: Lazewska D; Kiec-Kononowicz K; Elz S; Pertz H H; Stark H; Schunack W
Piperidine-containing histamine H3 receptor antagonists of the carbamate series: the alkyl derivatives.
Die Pharmazie 2005;60(6):403-10.
2004: Dove Stefan; Elz Sigurd; Seifert Roland; Buschauer Armin
Structure-activity relationships of histamine H2 receptor ligands.
Mini reviews in medicinal chemistry 2004;4(9):941-54.
2004: Pertz Heinz H; Elz Sigurd; Schunack Walter
Structure-activity relationships of histamine H1-receptor agonists.
Mini reviews in medicinal chemistry 2004;4(9):935-40.
2004: Sadek B; Elz S; Pertz H H; Stark H; Schunack W
Unexpected partial H1-receptor agonism of imidazole-type histamine H3-receptor antagonists lacking a basic side chain.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2004;53 Suppl 2():S109-15.
2003: Govoni Marinella; Bakker Remko A; van de Wetering Ineke; Smit Martine J; Menge Wiro M B P; Timmerman Henk; Elz Sigurd; Schunack Walter; Leurs Rob
Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists.
Journal of medicinal chemistry 2003;46(26):5812-24.
2003: Menghin Sonja; Pertz Heinz H; Kramer Kai; Seifert Roland; Schunack Walter; Elz Sigurd
N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists.
Journal of medicinal chemistry 2003;46(25):5458-70.
2003: Seifert Roland; Wenzel-Seifert Katharina; Burckstummer Tilmann; Pertz Heinz H; Schunack Walter; Dove Stefan; Buschauer Armin; Elz Sigurd
Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1104-15.
2003: Li Liantao; Kracht Julia; Peng Shiqi; Bernhardt Günther; Elz Sigurd; Buschauer Armin
Synthesis and pharmacological activity of fluorescent histamine H2 receptor antagonists related to potentidine.
Bioorganic & medicinal chemistry letters 2003;13(10):1717-20.
2002: Lazewska D; Kiec-Kononowicz K; Pertz H H; Elz S; Stark H; Schunack W
Piperidine-containing histamine H3 receptor antagonists of the carbamate series: the influence of the additional ether functionality.
Die Pharmazie 2002;57(12):791-5.
2002: El-Subbagh Hussein; Wittig Thomas; Decker Michael; Elz Sigurd; Nieger Martin; Lehmann Jochen
Dopamine/serotonin receptor ligands. Part IV [1]: synthesis and pharmacology of novel 3-benzazecines and 3-benzazonines as potential 5-HT2A and dopamine receptor ligands.
Archiv der Pharmazie 2002;335(9):443-8.
2002: Sasse Astrid; Ligneau Xavier; Rouleau Agnès; Elz Sigurd; Ganellin C Robin; Arrang Jean-Michel; Schwartz Jean-Charles; Schunack Walter; Stark Holger
Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties.
Journal of medicinal chemistry 2002;45(18):4000-10.
2002: Grassmann Sven; Sadek Bassem; Ligneau Xavier; Elz Sigurd; Ganellin C Robin; Arrang Jean-Michel; Schwartz Jean-Charles; Stark Holger; Schunack Walter
Progress in the proxifan class: heterocyclic congeners as novel potent and selective histamine H(3)-receptor antagonists.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2002;15(4):367-78.
2001: Lazewska D; Kiec-Kononowicz K; Pertz H H; Stark H; Schunack W; Elz S
Piperidine-containing histamine H3-receptor antagonists of the carbamate series: variation of the spacer length.
Die Pharmazie 2001;56(12):927-32.
2001: Schlicker E; Kozlowska H; Kwolek G; Malinowska B; Kramer K; Pertz H H; Elz S; Schunack W
Novel histaprodifen analogues as potent histamine H1-receptor agonists in the pithed and in the anaesthetized rat.
Naunyn-Schmiedeberg's archives of pharmacology 2001;364(1):14-20.
2001: Meier G; Apelt J; Reichert U; Grassmann S; Ligneau X; Elz S; Leurquin F; Ganellin C R; Schwartz J C; Schunack W; Stark H
Influence of imidazole replacement in different structural classes of histamine H(3)-receptor antagonists.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;13(3):249-59.
2001: Sasse A; Ligneau X; Sadek B; Elz S; Pertz H H; Ganellin C R; Arrang J M; Schwartz J C; Schunack W; Stark H
Benzophenone derivatives and related compounds as potent histamine H3-receptor antagonists and potential PET/SPECT ligands.
Archiv der Pharmazie 2001;334(2):45-52.
2000: Sasse A; Sadek B; Ligneau X; Elz S; Pertz H H; Luger P; Ganellin C R; Arrang J M; Schwartz J C; Schunack W; Stark H
New histamine H(3)-receptor ligands of the proxifan series: imoproxifan and other selective antagonists with high oral in vivo potency.
Journal of medicinal chemistry 2000;43(17):3335-43.
2000: Kiec-Kononowicz K; Wiecek M; Sasse A; Ligneau X; Elz S; Ganellin C R; Schwartz J C; Stark H; Schunack W
Importance of the lipophilic group in carbamates having histamine H3-receptor antagonist activity.
Die Pharmazie 2000;55(5):349-55.
2000: Sasse A; Stark H; Ligneau X; Elz S; Reidemeister S; Ganellin C R; Schwartz J C; Schunack W
(Partial) agonist/antagonist properties of novel diarylalkyl carbamates on histamine H3 receptors.
Bioorganic & medicinal chemistry 2000;8(5):1139-49.
2000: Elz S; Kramer K; Pertz H H; Detert H; ter Laak A M; Kühne R; Schunack W
Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists.
Journal of medicinal chemistry 2000;43(6):1071-84.
2000: Elz S; Kramer K; Leschke C; Schunack W
Ring-substituted histaprodifen analogues as partial agonists for histamine H(1) receptors: synthesis and structure-activity relationships.
European journal of medicinal chemistry 2000;35(1):41-52.
1999: Pietzsch H J; Scheunemann M; Kretzschmar M; Elz S; Pertz H H; Seifert S; Brust P; Spies H; Syhre R; Johannsen B
Synthesis and autoradiographic evaluation of a novel high-affinity Tc-99m ligand for the 5-HT2A receptor.
Nuclear medicine and biology 1999;26(8):865-75.
1999: Sasse A; Stark H; Reidemeister S; Hüls A; Elz S; Ligneau X; Ganellin C R; Schwartz J C; Schunack W
Novel partial agonists for the histamine H(3) receptor with high in vitro and in vivo activity.
Journal of medicinal chemistry 1999;42(20):4269-74.
1999: Malinowska B; Piszcz J; Schlicker E; Kramer K; Elz S; Schunack W
Histaprodifen, methylhistaprodifen, and dimethylhistaprodifen are potent H1-receptor agonists in the pithed and in the anaesthetized rat.
Naunyn-Schmiedeberg's archives of pharmacology 1999;359(1):11-6.
1998: Ligneau X; Lin J; Vanni-Mercier G; Jouvet M; Muir J L; Ganellin C R; Stark H; Elz S; Schunack W; Schwartz J
Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist.
The Journal of pharmacology and experimental therapeutics 1998;287(2):658-66.
1998: Kramer K; Elz S; Pertz H H; Schunack W
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
Bioorganic & medicinal chemistry letters 1998;8(18):2583-8.
1998: Timm J; Marr I; Werthwein S; Elz S; Schunack W; Schlicker E
H2 receptor-mediated facilitation and H3 receptor-mediated inhibition of noradrenaline release in the guinea-pig brain.
Naunyn-Schmiedeberg's archives of pharmacology 1998;357(3):232-9.
1995: Schlicker E; Pertz H; Bitschnau H; Purand K; Kathmann M; Elz S; Schunack W
Effects of iodoproxyfan, a potent and selective histamine H3 receptor antagonist, on alpha 2 and 5-HT3 receptors.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1995;44(7):296-300.
1995: Elz S; Keller A
Preparation and in vitro pharmacology of 5-HT4 receptor ligands. Partial agonism and antagonism of metoclopramide analogous benzoic esters.
Archiv der Pharmazie 1995;328(7-8):585-94.
1995: Pertz H; Elz S
In-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-HT2A receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail artery.
The Journal of pharmacy and pharmacology 1995;47(4):310-6.
1995: Leschke C; Elz S; Garbarg M; Schunack W
Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
Journal of medicinal chemistry 1995;38(8):1287-94.
1994: Monti J M; Jantos H; Leschke C; Elz S; Schunack W
The selective histamine H1-receptor agonist 2-(3-trifluoromethylphenyl)histamine increases waking in the rat.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 1994;4(4):459-62.
1993: Elz S; Zimmermann H; Rehse K
Selectivity of sterically fixed tryptamine and 5-methoxytryptamine derivatives for serotonin receptor subtypes, II: Structure-activity relationships and in vitro pharmacology of N-alkyl- and N,N-dialkyl-3- indolylbicyclo-[2.2.1]-heptane-2-amines.
Archiv der Pharmazie 1993;326(11):893-9.
1993: Radwansky A; Elz S; Lehmann J
Lactones, XXY: Synthesis and 5-HT2-receptor affinity of some fluorophenylated alpha-aminomethyllactones.
Archiv der Pharmazie 1993;326(4):243-4.
1992: Sellier C; Elz S; Buschauer A; Schunack W
The effect of lipophilic substituents on the H2-histaminergic activity of some close analogues of impromidine.
Archiv der Pharmazie 1992;325(8):471-6.
1992: Hirschfeld J; Buschauer A; Elz S; Schunack W; Ruat M; Traiffort E; Schwartz J C
Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor.
Journal of medicinal chemistry 1992;35(12):2231-8.

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