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David Emery

Research Profile

Chemicals & Drugs

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Gene Transfer Techniques

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beta-Thalassemia

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Publications

TOP 3
David W Emery
The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors.
Amy C Groth; David W Emery
A functional screen for regulatory elements that improve retroviral vector gene expression.
Evangelia Yannaki; David W Emery; George Stamatoyannopoulos
Gene therapy for β-thalassaemia: the continuing challenge.

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All Publications

2011: David W Emery
The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors.
Human gene therapy 2011;22(6):761-74.
2010: Amy C Groth; David W Emery
A functional screen for regulatory elements that improve retroviral vector gene expression.
Blood cells, molecules & diseases 2010;45(4):343-50.
2010: Evangelia Yannaki; David W Emery; George Stamatoyannopoulos
Gene therapy for β-thalassaemia: the continuing challenge.
Expert reviews in molecular medicine 2010;12():e31.
2009: Chang Long Li; Ding Xiong; George Stamatoyannopoulos; David W Emery
Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(4):716-24.
2008: C L Li; David W Emery
The cHS4 chromatin insulator reduces gammaretroviral vector silencing by epigenetic modifications of integrated provirus.
Gene therapy 2008;15(1):49-53.
2007: Mari Aker; Julie Tubb; Amy C Groth; Anatoly A Bukovsky; Adam C Bell; Gary Felsenfeld; Hans-Peter Kiem; George Stamatoyannopoulos; David W Emery
Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects.
Human gene therapy 2007;18(4):333-43.
2007: David W Emery; Georgios Gavriilidis; Haruhiko Asano; George Stamatoyannopoulos
The transcription factor KLF11 can induce gamma-globin gene expression in the setting of in vivo adult erythropoiesis.
Journal of cellular biochemistry 2007;100(4):1045-55.
2006: Mari Aker; Julie Tubb; Daniel G Miller; George Stamatoyannopoulos; David W Emery
Integration bias of gammaretrovirus vectors following transduction and growth of primary mouse hematopoietic progenitor cells with and without selection.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(2):226-35.
2006: Tamon Nishino; Julie Tubb; David W Emery
Partial correction of murine beta-thalassemia with a gammaretrovirus vector for human gamma-globin.
Blood cells, molecules & diseases 2006;37(1):1-7.
2006: Tamon Nishino; Hua Cao; George Stamatoyannopoulos; David W Emery
Effects of human gamma-globin in murine beta-thalassaemia.
British journal of haematology 2006;134(1):100-8.
2005: Michalis Fragkos; Nicholas P Anagnou; Julie Tubb; David W Emery
Use of the hereditary persistence of fetal hemoglobin 2 enhancer to increase the expression of oncoretrovirus vectors for human gamma-globin.
Gene therapy 2005;12(21):1591-600.
2005: Julie Tubb; Amy C Groth; Louis Leong; David W Emery
Simultaneous sequence transfer into two independent locations of a reporter vector using MultiSite Gateway technology.
BioTechniques 2005;39(4):553-7.
2005: David W Emery; Julie Tubb; Yumiko Nishino; Tamon Nishino; Kevin Otto; George Stamatoyannopoulos; C Anthony Blau
Selection with a regulated cell growth switch increases the likelihood of expression for a linked gamma-globin gene.
Blood cells, molecules & diseases 2005;34(3):235-47.
2005: Qiliang Li; David W Emery; Hemei Han; Jin Sun; Man Yu; George Stamatoyannopoulos
Differences of globin transgene expression in stably transfected cell lines and transgenic mice.
Blood 2005;105(8):3346-52.
2002: David W Emery; Evangelia Yannaki; Julie Tubb; Tamon Nishino; Qiliang Li; George Stamatoyannopoulos
Development of virus vectors for gene therapy of beta chain hemoglobinopathies: flanking with a chromatin insulator reduces gamma-globin gene silencing in vivo.
Blood 2002;100(6):2012-9.
2002: David W Emery; David M Bodine
The third conference on hematopoietic stem cell gene therapy: biology and technology.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(6):658-63.
2002: Evangelia Yannaki; Julie Tubb; Mari Aker; George Stamatoyannopoulos; David W Emery
Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(5 Pt 1):589-98.
2002: David W Emery; Tamon Nishino; Ken Murata; Michalis Fragkos; George Stamatoyannopoulos
Hematopoietic stem cell gene therapy.
International journal of hematology 2002;75(3):228-36.
2000: David W Emery; Evangelia Yannaki; Julie Tubb; George Stamatoyannopoulos
A chromatin insulator protects retrovirus vectors from chromosomal position effects.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9150-5.
2000: David W Emery; Robert G Andrews; Thalia Papayannopoulou
Differences among nonhuman primates in susceptibility to bone marrow progenitor transduction with retrovirus vectors.
Gene therapy 2000;7(5):359-67.
1999: David W Emery; George Stamatoyannopoulos
Stem cell gene therapy for the beta-chain hemoglobinopathies. Problems and progress.
Annals of the New York Academy of Sciences 1999;872():94-107; discussion 107-8.
1999: David W Emery; F Morrish; Qiliang Li; George Stamatoyannopoulos
Analysis of gamma-globin expression cassettes in retrovirus vectors.
Human gene therapy 1999;10(6):877-88.
1999: Qiliang Li; David W Emery; M Fernandez; Hemei Han; George Stamatoyannopoulos
Development of viral vectors for gene therapy of beta-chain hemoglobinopathies: optimization of a gamma-globin gene expression cassette.
Blood 1999;93(7):2208-16.
1998: David W Emery; H Chen; Qiliang Li; George Stamatoyannopoulos
Development of a condensed locus control region cassette and testing in retrovirus vectors for A gamma-globin.
Blood cells, molecules & diseases 1998;24(3):322-39.
1998: L Jin; Noppadol Siritanaratkul; David W Emery; Robert E Richard; Kenneth Kaushansky; Thalia Papayannopoulou; C Anthony Blau
Targeted expansion of genetically modified bone marrow cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):8093-7.
1990: Karol Bomsztyk; Bert Toivola; David W Emery; J W Rooney; Steven K Dower; N A Rachie; Carol Hopkins Sibley
Role of cAMP in interleukin-1-induced kappa light chain gene expression in murine B cell line.
The Journal of biological chemistry 1990;265(16):9413-7.
1990: J W Rooney; David W Emery; Carol Hopkins Sibley
Slow response variant of the B lymphoma 70Z/3 defective in LPS activation of NF-kappa B.
Immunogenetics 1990;31(2):65-72.
1990: J W Rooney; David W Emery; Carol Hopkins Sibley
1.3E2, a variant of the B lymphoma 70Z/3, defective in activation of NF-kappa B and OTF-2.
Immunogenetics 1990;31(2):73-8.
1989: David W Emery; J W Rooney; Carol Hopkins Sibley
A gamma interferon-unresponsive variant of cell line 70Z/3, IFN-4, can be partially rescued by phorbol myristate acetate.
Molecular and cellular biology 1989;9(11):5231-3.