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Emilio Emini

Research Profile

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Kristina A Bryant; Carmel Devlin; Emilio A Emini; Douglas Girgenti; William C Gruber; Alejandra Gurtman; Anthony Johnson; Scott Patterson; Michael W Pride; Keith Reisinger; Daniel A Scott
Antibody responses to routine pediatric vaccines administered with 13-valent pneumococcal conjugate vaccine.
Dong Soo Kim; Ki Hwan Kim; Hoan Jong Lee; Soo Young Lee; Chi Eun Oh; Scott Patterson; Kyong Min Choi; Emilio A Emini; Peter C Giardina; William C Gruber; Young Jin Hong; Christine Juergens; Seon Hee Shin; Daniel A Scott
Immunogenicity and safety of 13-valent pneumococcal conjugate vaccine given to korean children receiving routine pediatric vaccines.
Rosalyn Singleton; Allison Thompson; Jay Wenger; Lisa R Bulkow; Emilio A Emini; William C Gruber; Joseph A Klejka; Denise Sarkozy; Daniel A Scott
The 13-valent pneumococcal conjugate vaccine for invasive pneumococcal disease in Alaska native children: results of a clinical trial.

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2013: Kristina A Bryant; Carmel Devlin; Emilio A Emini; Douglas Girgenti; William C Gruber; Alejandra Gurtman; Anthony Johnson; Scott Patterson; Michael W Pride; Keith Reisinger; Daniel A Scott
Antibody responses to routine pediatric vaccines administered with 13-valent pneumococcal conjugate vaccine.
The Pediatric infectious disease journal 2013;32(4):383-8.
2013: Dong Soo Kim; Ki Hwan Kim; Hoan Jong Lee; Soo Young Lee; Chi Eun Oh; Scott Patterson; Kyong Min Choi; Emilio A Emini; Peter C Giardina; William C Gruber; Young Jin Hong; Christine Juergens; Seon Hee Shin; Daniel A Scott
Immunogenicity and safety of 13-valent pneumococcal conjugate vaccine given to korean children receiving routine pediatric vaccines.
The Pediatric infectious disease journal 2013;32(3):266-73.
2013: Rosalyn Singleton; Allison Thompson; Jay Wenger; Lisa R Bulkow; Emilio A Emini; William C Gruber; Joseph A Klejka; Denise Sarkozy; Daniel A Scott
The 13-valent pneumococcal conjugate vaccine for invasive pneumococcal disease in Alaska native children: results of a clinical trial.
The Pediatric infectious disease journal 2013;32(3):257-63.
2013: Sven-Arne Silfverdal; Susan P Tansey; James Trammel; Emilio A Emini; Carl-Erik Flodmark; William C Gruber; Alejandra Gurtman; Lars Rombo; Daniel A Scott; Mohinder Sidhu
13-Valent pneumococcal conjugate vaccine (PCV13) in children partially immunized with 7-valent pneumococcal conjugate vaccine (PCV7): a phase 3, open-label trial.
Vaccine 2013;31(9):1284-92.
2012: Lily Yin Weckx; Eitan Naaman Berezin; Clovis Arns da Cunha; Sonia Maria de Faria; Emilio A Emini; William C Gruber; Scott Patterson; Michael William Pride; Daniel A Scott; Allison Thompson
A phase 3, randomized, double-blind trial comparing the safety and immunogenicity of the 7-valent and 13-valent pneumococcal conjugate vaccines, given with routine pediatric vaccinations, in healthy infants in Brazil.
Vaccine 2012;30(52):7566-72.
2012: William C Gruber; Daniel A Scott; Emilio A Emini
Development and clinical evaluation of Prevnar 13, a 13-valent pneumocococcal CRM197 conjugate vaccine.
Annals of the New York Academy of Sciences 2012;1263():15-26.
2012: Robert W Frenck; Peter C Giardina; William C Gruber; Alejandra Gurtman; Deepthi Jayawardene; John Rubino; Daniel A Scott; William Smith; Martin van Cleeff; Emilio A Emini; Beate Schmöle-Thoma
Randomized, controlled trial of a 13-valent pneumococcal conjugate vaccine administered concomitantly with an influenza vaccine in healthy adults.
Clinical and vaccine immunology : CVI 2012;19(8):1296-303.
2012: Federico Martinón-Torres; Denise A Sarkozy; Daniel A Scott; Mohinder Sidhu; Enrique Bernaola; Alfonso Carmona; Javier Diez-Domingo; Emilio A Emini; Francisco Gimenez-Sanchez; William C Gruber; Alejandra Gurtman
13-valent pneumococcal conjugate vaccine given with meningococcal C-tetanus toxoid conjugate and other routine pediatric vaccinations: immunogenicity and safety.
The Pediatric infectious disease journal 2012;31(4):392-9.
2012: Otto G Vanderkooi; Emilio A Emini; Douglas Girgenti; William C Gruber; Scott A Halperin; James D Kellner; Scott D Patterson; David W Scheifele; Daniel A Scott
Safety and immunogenicity of a 13-valent pneumococcal conjugate vaccine in healthy infants and toddlers given with routine pediatric vaccinations in Canada.
The Pediatric infectious disease journal 2012;31(1):72-7.
2011: Francisco Gimenez-Sanchez; William C Gruber; Alejandra Gurtman; Christine Juergens; Dorothee M Kieninger; Kathrin Kueper; John Z Liang; Federico Martinon-Torres; Daniel A Scott; Kathrin Steul; Enrique Bernaola; Javier Diez-Domingo; Emilio A Emini; Peter Giardina
Immunogenicity of a combination vaccine containing diphtheria toxoid, tetanus toxoid, three-component acellular pertussis, hepatitis B, inactivated polio virus, and Haemophilus influenzae type b when given concomitantly with 13-valent pneumococcal conjugate vaccine.
Vaccine 2011;29(35):6042-8.
2011: Janusz Gadzinowski; Piotr Albrecht; Barbara Hasiec; Ryszard Konior; Jerzy Dziduch; Anita Witor; Tracey Mellelieu; Susan P Tansey; Thomas Jones; Denise Sarkozy; Emilio A Emini; William C Gruber; Daniel A Scott
Phase 3 trial evaluating the immunogenicity, safety, and tolerability of manufacturing scale 13-valent pneumococcal conjugate vaccine.
Vaccine 2011;29(16):2947-55.
2010: Matthew D Snape; Chaam L Klinger; Elvis D Daniels; Tessa M John; Helen Layton; Llinos Rollinson; Sarah Pestridge; Sandra Dymond; Eva Galiza; Susan Tansey; Daniel A Scott; Sherryl A Baker; Thomas R Jones; Ly-Mee Yu; William C Gruber; Emilio A Emini; Saul N Faust; Adam Finn; Paul Heath; Andrew J Pollard
Immunogenicity and reactogenicity of a 13-valent-pneumococcal conjugate vaccine administered at 2, 4, and 12 months of age: a double-blind randomized active-controlled trial.
The Pediatric infectious disease journal 2010;29(12):e80-90.
2010: Sylvia H Yeh; Alejandra Gurtman; David C Hurley; Stan L Block; Richard H Schwartz; Scott Patterson; Kathrin U Jansen; Jack Love; William C Gruber; Emilio A Emini; Daniel A Scott
Immunogenicity and safety of 13-valent pneumococcal conjugate vaccine in infants and toddlers.
Pediatrics 2010;126(3):e493-505.
2010: Dorothee M Kieninger; Kathrin Kueper; Katrin Steul; Christine Juergens; Norbert Ahlers; Sherryl Baker; Kathrin U Jansen; Carmel Devlin; William C Gruber; Emilio A Emini; Daniel A Scott
Safety, tolerability, and immunologic noninferiority of a 13-valent pneumococcal conjugate vaccine compared to a 7-valent pneumococcal conjugate vaccine given with routine pediatric vaccinations in Germany.
Vaccine 2010;28(25):4192-203.
2010: Susanna Esposito; Susan Tansey; Allison Thompson; Ahmad Razmpour; John Liang; Thomas R Jones; Giuseppe Ferrera; Alessandro Maida; Gianni Bona; Caterina Sabatini; Lorenza Pugni; Emilio A Emini; William C Gruber; Daniel A Scott; Nicola Principi
Safety and immunogenicity of a 13-valent pneumococcal conjugate vaccine compared to those of a 7-valent pneumococcal conjugate vaccine given as a three-dose series with routine vaccines in healthy infants and toddlers.
Clinical and vaccine immunology : CVI 2010;17(6):1017-26.
2009: Mike Flint; Stanley Mullen; Anne M Deatly; Wei Chen; Lynn Z Miller; Robert Ralston; Colin Broom; Emilio A Emini; Anita Y M Howe
Selection and characterization of hepatitis C virus replicons dually resistant to the polymerase and protease inhibitors HCV-796 and boceprevir (SCH 503034).
Antimicrobial agents and chemotherapy 2009;53(2):401-11.
2007: Subharekha Raghavan; Zhijian Lu; Teresa Beeson; Kevin Chapman; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Lori Gabryelski; Emilio A Emini; James R Tata
Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus.
Bioorganic & medicinal chemistry letters 2007;17(19):5432-6.
2007: Zhi-Qiang Zhang; Danilo R Casimiro; William A Schleif; Minchun Chen; Michael P Citron; Mary-Ellen Davies; Janine Burns; Xiaoping Liang; Tong-Ming Fu; Larry Handt; Emilio A Emini; John W Shiver
Early depletion of proliferating B cells of germinal center in rapidly progressive simian immunodeficiency virus infection.
Virology 2007;361(2):455-64.
2007: Tong-Ming Fu; Sheri A Dubey; Devan V Mehrotra; Daniel C Freed; Wendy Trigona; Lisa Adams-Muhler; James H Clair; Thomas G Evans; Roy T Steigbigel; Jeffrey M Jacobson; Paul A Goepfert; Mark MULLIGAN; Spyros A Kalams; Charles Rinaldo; Lan Zhu; Kara S Cox; Liming Guan; Romnie Long; Natasha Persaud; Michael J Caulfield; Jerald C Sadoff; Emilio A Emini; Scott Thaler; John W Shiver
Evaluation of cellular immune responses in subjects chronically infected with HIV type 1.
AIDS research and human retroviruses 2007;23(1):67-76.
2005: Zhijian Lu; Joann Bohn; Thomas A Rano; Carrie A Rutkowski; Amy L Simcoe; David B Olsen; William A Schleif; Anthony Carella; Lori Gabryelski; Lixia Jin; Jiunn H Lin; Emilio A Emini; Kevin Chapman; James R Tata
Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus.
Bioorganic & medicinal chemistry letters 2005;15(23):5311-4.
2005: Xiaoping Liang; Danilo R Casimiro; William A Schleif; Fubao Wang; Mary-Ellen Davies; Zhi-Qiang Zhang; Tong-Ming Fu; Adam C Finnefrock; Larry Handt; Michael P Citron; Gwendolyn J Heidecker; Aimin Tang; Minchun Chen; Keith A Wilson; Lori Gabryelski; Michael McElhaugh; Anthony Carella; Cheryl Moyer; Lingyi Huang; Salvatore Vitelli; Deepa Patel; Jing Lin; Emilio A Emini; John W Shiver
Vectored Gag and Env but not Tat show efficacy against simian-human immunodeficiency virus 89.6P challenge in Mamu-A*01-negative rhesus monkeys.
Journal of virology 2005;79(19):12321-31.
2005: Elisabetta Bianchi; Xiaoping Liang; Paolo Ingallinella; Marco Finotto; Michael A Chastain; Jiang Fan; Tong-Ming Fu; Hong Chang Song; Melanie S Horton; Daniel C Freed; Walter Manger; Emily Wen; Li Shi; Roxana Ionescu; Colleen Price; Marc Wenger; Emilio A Emini; Riccardo Cortese; Gennaro Ciliberto; John W Shiver; Antonello Pessi
Universal influenza B vaccine based on the maturational cleavage site of the hemagglutinin precursor.
Journal of virology 2005;79(12):7380-8.
2005: Paul M Coplan; Swati B Gupta; Sheri A Dubey; Punnee Pitisuttithum; Alexander Nikas; Bernard Mbewe; Eftyhia Vardas; Mauro Schechter; Esper Kallas; Daniel C Freed; Tong-Ming Fu; Christopher T Mast; Pilaipan Puthavathana; James Kublin; Kelly Brown Collins; John Chisi; Richard Pendame; Scott Thaler; Glenda Gray; James McIntyre; Walter L Straus; Jon H Condra; Devan V Mehrotra; Harry A Guess; Emilio A Emini; John W Shiver
Cross-reactivity of anti-HIV-1 T cell immune responses among the major HIV-1 clades in HIV-1-positive individuals from 4 continents.
The Journal of infectious diseases 2005;191(9):1427-34.
2005: Dooseop Kim; Liping Wang; Jeffrey J Hale; Christopher L Lynch; Richard J Budhu; Malcolm MacCoss; Sander G Mills; Lorraine Malkowitz; Sandra L Gould; Julie A DeMartino; Martin S Springer; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee C Hrin; Gwen Carver; Anthony Carella; Karen Henry; Janet Lineberger; William A Schleif; Emilio A Emini
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties.
Bioorganic & medicinal chemistry letters 2005;15(8):2129-34.
2005: Shrenik K Shah; Natalie Chen; Ravindra N Guthikonda; Sander G Mills; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini; Malcolm MacCoss
Synthesis and evaluation of CCR5 antagonists containing modified 4-piperidinyl-2-phenyl-1-(phenylsulfonylamino)-butane.
Bioorganic & medicinal chemistry letters 2005;15(4):977-82.
2004: Danilo R Casimiro; Andrew J Bett; Tong-Ming Fu; Mary-Ellen Davies; Aimin Tang; Keith A Wilson; Minchun Chen; Romnie Long; Troy W McKelvey; Michael A Chastain; Sanjay Gurunathan; Jim Tartaglia; Emilio A Emini; John W Shiver
Heterologous human immunodeficiency virus type 1 priming-boosting immunization strategies involving replication-defective adenovirus and poxvirus vaccine vectors.
Journal of virology 2004;78(20):11434-8.
2004: Ronald M Kim; Elizabeth A Rouse; Kevin Chapman; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Emilio A Emini; James R Tata
P1' oxadiazole protease inhibitors with excellent activity against native and protease inhibitor-resistant HIV-1.
Bioorganic & medicinal chemistry letters 2004;14(18):4651-4.
2004: Jiang Fan; Xiaoping Liang; Melanie S Horton; Helen C Perry; Michael P Citron; Gwendolyn J Heidecker; Tong-Ming Fu; Joseph Joyce; Craig T Przysiecki; Paul M Keller; Victor M Garsky; Roxana Ionescu; Yvette Rippeon; Li Shi; Michael A Chastain; Jon H Condra; Mary-Ellen Davies; Jason Liao; Emilio A Emini; John W Shiver
Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys.
Vaccine 2004;22(23-24):2993-3003.
2004: Emilio A Emini; David B Weiner
AIDS vaccines.
Expert review of vaccines 2004;3(4 Suppl):S1-2.
2004: Daria J Hazuda; Steven D Young; James P Guare; Neville J Anthony; Robert P Gomez; John S Wai; Joseph P Vacca; Larry Handt; Sherri L Motzel; Hilton J Klein; Geethanjali Dornadula; Robert M Danovich; Marc V Witmer; Keith A Wilson; Lynda Tussey; William A Schleif; Lori S Gabryelski; Lixia Jin; Michael D Miller; Danilo R Casimiro; Emilio A Emini; John W Shiver
Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques.
Science (New York, N.Y.) 2004;305(5683):528-32.
2004: K Shankaran; Karla L Donnelly; Shrenik K Shah; Charles G Caldwell; Ping Chen; Paul E Finke; Bryan Oates; Malcolm MacCoss; Sander G Mills; Julie A DeMartino; Sandra L Gould; Lorraine Malkowitz; Salvatore J Siciliano; Martin S Springer; Gloria Y Kwei; Anthony Carella; Gwen Carver; Renee Danzeisen; Daria J Hazuda; Karen Holmes; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini; William A Schleif
Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists.
Bioorganic & medicinal chemistry letters 2004;14(13):3589-93.
2004: K Shankaran; Karla L Donnelly; Shrenik K Shah; Ravindra N Guthikonda; Malcolm MacCoss; Sander G Mills; Sandra L Gould; Lorraine Malkowitz; Salvatore J Siciliano; Martin S Springer; Anthony Carella; Gwen Carver; Daria J Hazuda; Karen Holmes; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini; William A Schleif
Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor.
Bioorganic & medicinal chemistry letters 2004;14(13):3419-24.
2004: Emilio A Emini; Wayne C Koff
AIDS/HIV. Developing an AIDS vaccine: need, uncertainty, hope.
Science (New York, N.Y.) 2004;304(5679):1913-4.
2004: David Opalka; Antonello Pessi; Elisabetta Bianchi; Gennaro Ciliberto; William A Schleif; Michael McElhaugh; Renee Danzeisen; Romas Geleziunas; Michael Miller; Debra M Eckert; David Bramhill; Joseph Joyce; James Cook; William Magilton; John W Shiver; Emilio A Emini; MARK ESSER
Analysis of the HIV-1 gp41 specific immune response using a multiplexed antibody detection assay.
Journal of immunological methods 2004;287(1-2):49-65.
2004: Zhi-Qiang Zhang; William A Schleif; Danilo R Casimiro; Larry Handt; Minchun Chen; Mary-Ellen Davies; Xiaoping Liang; Tong-Ming Fu; Aimin Tang; Keith A Wilson; Michael McElhaugh; Anthony Carella; Charles Tan; Brett Connolly; Susan Hill; Hilton Klein; Emilio A Emini; John W Shiver
The impact of early immune destruction on the kinetics of postacute viral replication in rhesus monkey infected with the simian-human immunodeficiency virus 89.6P.
Virology 2004;320(1):75-84.
2004: Min Shu; Jennifer L Loebach; Kerry A Parker; Sander G Mills; Kevin Chapman; Dong-Ming Shen; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Jerry Di Salvo; Kathryn Lyons; James V Pivnichny; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.
Bioorganic & medicinal chemistry letters 2004;14(4):947-52.
2004: Dong-Ming Shen; Min Shu; Christopher A Willoughby; Shrenik Shah; Christopher L Lynch; Jeffrey J Hale; Sander G Mills; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Kathryn Lyons; James V Pivnichny; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds.
Bioorganic & medicinal chemistry letters 2004;14(4):941-5.
2004: Dong-Ming Shen; Min Shu; Sander G Mills; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains.
Bioorganic & medicinal chemistry letters 2004;14(4):935-9.
2004: John W Shiver; Emilio A Emini
Recent advances in the development of HIV-1 vaccines using replication-incompetent adenovirus vectors.
Annual review of medicine 2004;55():355-72.
2003: Nancy J Kevin; Joseph L Duffy; Brian A Kirk; Kevin Chapman; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Lawrence C Kuo; Lixia Jin; Jiunn H Lin; Emilio A Emini; James R Tata
Novel HIV-1 protease inhibitors active against multiple PI-resistant viral strains: coadministration with indinavir.
Bioorganic & medicinal chemistry letters 2003;13(22):4027-30.
2003: Joseph L Duffy; Brian A Kirk; Nancy J Kevin; Kevin Chapman; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Lawrence C Kuo; Lixia Jin; Jiunn H Lin; Emilio A Emini; James R Tata
HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1' substituent.
Bioorganic & medicinal chemistry letters 2003;13(19):3323-6.
2003: Rafael E Campo; Jose N Moreno; German Suarez; Nancimae Miller; Michael A Kolber; Daniel J Holder; Malathi Shivaprakash; Dana M DeAngelis; Jennifer L Wright; William A Schleif; Emilio A Emini; Jon H Condra
Efficacy of indinavir-ritonavir-based regimens in HIV-1-infected patients with prior protease inhibitor failures.
AIDS (London, England) 2003;17(13):1933-9.
2003: Fengqi Zhang; Kevin Chapman; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Lawrence C Kuo; Lixia Jin; Jiunn H Lin; Emilio A Emini; James R Tata
The design, synthesis and evaluation of novel HIV-1 protease inhibitors with high potency against PI-resistant viral strains.
Bioorganic & medicinal chemistry letters 2003;13(15):2573-6.
2003: Joseph L Duffy; Thomas A Rano; Nancy J Kevin; Kevin Chapman; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Lawrence C Kuo; Lixia Jin; Jiunn H Lin; Emilio A Emini; James R Tata
HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent.
Bioorganic & medicinal chemistry letters 2003;13(15):2569-72.
2003: Christopher L Lynch; Jeffrey J Hale; Richard J Budhu; Amy L Gentry; Paul E Finke; Charles G Caldwell; Sander G Mills; Malcolm MacCoss; Dong-Ming Shen; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity.
Organic letters 2003;5(14):2473-5.
2003: Rima Youil; Timothy J Toner; Qin Su; Danilo R Casimiro; John W Shiver; Ling Chen; Andrew J Bett; Bethany M Rogers; Eric C Burden; Aimin Tang; Michelle Chen; Emilio A Emini; David C Kaslow; John G Aunins; Nedim E Altaras
Comparative analysis of the effects of packaging signal, transgene orientation, promoters, polyadenylation signals, and E3 region on growth properties of first-generation adenoviruses.
Human gene therapy 2003;14(10):1017-34.
2003: Danilo R Casimiro; Aimin Tang; Ling Chen; Tong-Ming Fu; Robert K Evans; Mary-Ellen Davies; Daniel C Freed; William M Hurni; Jose M Aste-Amezaga; Liming Guan; Romnie Long; Lingyi Huang; Virginia Harris; Denise K Nawrocki; Henryk Mach; Robert D Troutman; Lynne A Isopi; Krishna K Murthy; Karen Rice; Keith A Wilson; David B Volkin; Emilio A Emini; John W Shiver
Vaccine-induced immunity in baboons by using DNA and replication-incompetent adenovirus type 5 vectors expressing a human immunodeficiency virus type 1 gag gene.
Journal of virology 2003;77(13):7663-8.
2003: Zhijian Lu; Subharekha Raghavan; Joann Bohn; Mark Charest; Mark Stahlhut; Carrie A Rutkowski; Amy L Simcoe; David B Olsen; William A Schleif; Anthony Carella; Lori Gabryelski; Lixia Jin; Jiunn H Lin; Emilio A Emini; Kevin Chapman; James R Tata
Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus.
Bioorganic & medicinal chemistry letters 2003;13(10):1821-4.
2003: Christopher A Willoughby; Keith G Rosauer; Jeffrey J Hale; Richard J Budhu; Sander G Mills; Kevin Chapman; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
1,3,4 Trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains.
Bioorganic & medicinal chemistry letters 2003;13(3):427-31.
2003: Christopher L Lynch; Christopher A Willoughby; Jeffrey J Hale; Edward J Holson; Richard J Budhu; Amy L Gentry; Keith G Rosauer; Charles G Caldwell; Ping Chen; Sander G Mills; Malcolm MacCoss; Scott Berk; Liya Chen; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains.
Bioorganic & medicinal chemistry letters 2003;13(1):119-23.
2002: Zhi-Qiang Zhang; Tong-Ming Fu; Danilo R Casimiro; Mary-Ellen Davies; Xiaoping Liang; William A Schleif; Larry Handt; Lynda Tussey; Minchun Chen; Aimin Tang; Keith A Wilson; Wendy Trigona; Daniel C Freed; Charles Y Tan; Melanie Horton; Emilio A Emini; John W Shiver
Mamu-A*01 allele-mediated attenuation of disease progression in simian-human immunodeficiency virus infection.
Journal of virology 2002;76(24):12845-54.
2002: Christopher L Lynch; Jeffrey J Hale; Richard J Budhu; Amy L Gentry; Sander G Mills; Kevin Chapman; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
Bioorganic & medicinal chemistry letters 2002;12(20):3001-4.
2002: Jeffrey J Hale; Richard J Budhu; Sander G Mills; Malcolm MacCoss; Sandra L Gould; Julie A DeMartino; Martin S Springer; Salvatore J Siciliano; Lorraine Malkowitz; William A Schleif; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Karen Holmes; Janet Lineberger; Anthony Carella; Gwen Carver; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity.
Bioorganic & medicinal chemistry letters 2002;12(20):2997-3000.
2002: Subharekha Raghavan; Zheng Yang; Ralph T Mosley; William A Schleif; Lori Gabryelski; David B Olsen; Mark Stahlhut; Lawrence C Kuo; Emilio A Emini; Kevin Chapman; James R Tata
Combinatorial library of indinavir analogues: replacement for the aminoindanol at P2'.
Bioorganic & medicinal chemistry letters 2002;12(20):2855-8.
2002: Michael J Caulfield; Su Wang; Jeffrey G Smith; Timothy W Tobery; Xu Liu; Mary-Ellen Davies; Danilo R Casimiro; Tong-Ming Fu; Adam Simon; Robert K Evans; Emilio A Emini; John W Shiver
Sustained peptide-specific gamma interferon T-cell response in rhesus macaques immunized with human immunodeficiency virus gag DNA vaccines.
Journal of virology 2002;76(19):10038-43.
2002: Xaioping Liang; Tong-Ming Fu; Hong Xie; Emilio A Emini; John W Shiver
Development of HIV-1 Nef vaccine components: immunogenicity study of Nef mutants lacking myristoylation and dileucine motif in mice.
Vaccine 2002;20(27-28):3413-21.
2002: Joseph L Duffy; Nancy J Kevin; Brian A Kirk; Kevin Chapman; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Lawrence C Kuo; Lixia Jin; Jiunn H Lin; Emilio A Emini; James R Tata
Synthesis and activity of novel HIV protease inhibitors with improved potency against multiple PI-resistant viral strains.
Bioorganic & medicinal chemistry letters 2002;12(17):2423-6.
2002: Yuan Cheng; Fengqi Zhang; Thomas A Rano; Zhijian Lu; William A Schleif; Lori Gabryelski; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Jiunn H Lin; Lixia Jin; Emilio A Emini; Kevin Chapman; James R Tata
Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-resistant viral strains.
Bioorganic & medicinal chemistry letters 2002;12(17):2419-22.
2002: Christopher L Lynch; Amy L Gentry; Jeffrey J Hale; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; George A Doss; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines.
Bioorganic & medicinal chemistry letters 2002;12(4):677-9.
2002: Jon H Condra; Michael D Miller; Daria J Hazuda; Emilio A Emini
Potential new therapies for the treatment of HIV-1 infection.
Annual review of medicine 2002;53():541-55.
2002: Danilo R Casimiro; Aimin Tang; Helen C Perry; Romnie S Long; Minchun Chen; Gwendolyn J Heidecker; Mary-Ellen Davies; Daniel C Freed; Natasha Persaud; Sheri Dubey; Jeffrey G Smith; Diane V Havlir; Douglas Richman; Michael A Chastain; Adam J Simon; Tong-Ming Fu; Emilio A Emini; John W Shiver
Vaccine-induced immune responses in rodents and nonhuman primates by use of a humanized human immunodeficiency virus type 1 pol gene.
Journal of virology 2002;76(1):185-94.
2001: Christopher A Willoughby; Scott Berk; Keith G Rosauer; SJ Degrado; Kevin Chapman; Sandra L Gould; Martin S Springer; Lorraine Malkowitz; William A Schleif; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Karen Holmes; Janet Lineberger; Anthony Carella; Gwen Carver; Emilio A Emini
Combinatorial synthesis of CCR5 antagonists.
Bioorganic & medicinal chemistry letters 2001;11(24):3137-41.
2001: Dooseop Kim; Liping Wang; Charles G Caldwell; Ping Chen; Paul E Finke; Bryan Oates; Malcolm MacCoss; Sander G Mills; Lorraine Malkowitz; Sandra L Gould; Julie A DeMartino; Martin S Springer; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Gwen Carver; Anthony Carella; Karen Holmes; Janet Lineberger; William A Schleif; Emilio A Emini
Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection.
Bioorganic & medicinal chemistry letters 2001;11(24):3103-6.
2001: Dooseop Kim; Liping Wang; Charles G Caldwell; Ping Chen; Paul E Finke; Bryan Oates; Malcolm MacCoss; Sander G Mills; Lorraine Malkowitz; Sandra L Gould; Julie A DeMartino; Martin S Springer; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Gwen Carver; Anthony Carella; Karen Holmes; Janet Lineberger; William A Schleif; Emilio A Emini
Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.
Bioorganic & medicinal chemistry letters 2001;11(24):3099-102.
2001: Jeffrey J Hale; Richard J Budhu; E B Holson; Paul E Finke; Bryan Oates; Sander G Mills; Malcolm MacCoss; Sandra L Gould; Julie A DeMartino; Martin S Springer; Salvatore J Siciliano; Lorraine Malkowitz; William A Schleif; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Karen Holmes; Janet Lineberger; Anthony Carella; Gwen Carver; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent anti-HIV activity.
Bioorganic & medicinal chemistry letters 2001;11(20):2741-5.
2001: Paul E Finke; Bryan Oates; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Anthony Carella; Gwen Carver; Karen Holmes; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; William A Schleif; Emilio A Emini
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes.
Bioorganic & medicinal chemistry letters 2001;11(18):2475-9.
2001: Huldrych Günthard; Diane V Havlir; Susan A Fiscus; Z Q Zhang; Joseph J Eron; John Mellors; Roy M Gulick; Simon D W Frost; A J Brown; William A Schleif; Fred Valentine; L Jonas; Anne R Meibohm; Caroline C Ignacio; Robin Isaacs; R Gamagami; Emilio A Emini; A Haase; Douglas D Richman; Joseph Wong
Residual human immunodeficiency virus (HIV) Type 1 RNA and DNA in lymph nodes and HIV RNA in genital secretions and in cerebrospinal fluid after suppression of viremia for 2 years.
The Journal of infectious diseases 2001;183(9):1318-27.
2001: Paul E Finke; Laura C Meurer; Bryan Oates; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Bruce L Daugherty; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Anthony Carella; Gwen Carver; Karen Holmes; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; William A Schleif; Emilio A Emini
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure-activity relationships for substituted 2-Aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes.
Bioorganic & medicinal chemistry letters 2001;11(2):265-70.
2001: C P Dorn; Paul E Finke; Bryan Oates; Richard J Budhu; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Bruce L Daugherty; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Anthony Carella; Gwen Carver; Karen Holmes; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; William A Schleif; Emilio A Emini
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. part 1: discovery and initial structure-activity relationships for 1 -amino-2-phenyl-4-(piperidin-1-yl)butanes.
Bioorganic & medicinal chemistry letters 2001;11(2):259-64.
2000: Dan H Barouch; Sampa Santra; Joern schmitz; Marcelo J Kuroda; Tong-Ming Fu; W Wagner; M Bilska; A Craiu; Xin Xiao Zheng; Georgia R Krivulka; Kristin Beaudry; Michelle A Lifton; Christine E Nickerson; Wendy Trigona; K Punt; Daniel C Freed; Liming Guan; Sheri Dubey; Danilo R Casimiro; A Simon; Mary-Ellen Davies; Michael A Chastain; Terry B Strom; Rebecca Gelman; David C Montefiori; Mark G Lewis; Emilio A Emini; John W Shiver; Norman L Letvin
Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination.
Science (New York, N.Y.) 2000;290(5491):486-92.
2000: Bruce D Dorsey; Colleen McDonough; S L McDaniel; R B Levin; Christina L Newton; J M Hoffman; Paul L Darke; Joan Zugay-Murphy; Emilio A Emini; William A Schleif; David B Olsen; Mark Stahlhut; Carrie A Rutkowski; Lawrence C Kuo; Jiunn H Lin; I-Wu Chen; Stuart R Michelson; M Katharine Holloway; Joel R Huff; Joseph P Vacca
Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors.
Journal of medicinal chemistry 2000;43(18):3386-99.
2000: Jon H Condra; C J Petropoulos; R Ziermann; William A Schleif; Malathi Shivaprakash; Emilio A Emini
Drug resistance and predicted virologic responses to human immunodeficiency virus type 1 protease inhibitor therapy.
The Journal of infectious diseases 2000;182(3):758-65.
2000: Roy M Gulick; John W Mellors; Diane V Havlir; Joseph J Eron; Anne R Meibohm; Jon H Condra; Fred Valentine; Douglas McMahon; Charles Gonzalez; L Jonas; Emilio A Emini; Jeffrey A Chodakewitz; Robin Isaacs; Douglas D Richman
3-year suppression of HIV viremia with indinavir, zidovudine, and lamivudine.
Annals of internal medicine 2000;133(1):35-9.
2000: Zhongguo Chen; Youwei Yan; Sanjeev Munshi; Yueming Li; Joan Zugay-Murphy; Bei Xu; Marc V Witmer; Peter J Felock; Abigail Wolfe; Vinod Sardana; Emilio A Emini; Daria J Hazuda; Lawrence C Kuo
X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform.
Journal of molecular biology 2000;296(2):521-33.
1998: George L Drusano; John Bilello; Daniel S Stein; M Nessly; Anne R Meibohm; Emilio A Emini; P Deutsch; Jon H Condra; Jeffrey A Chodakewitz; Daniel J Holder
Factors influencing the emergence of resistance to indinavir: role of virologic, immunologic, and pharmacologic variables.
The Journal of infectious diseases 1998;178(2):360-7.
1998: Roy M Gulick; John W Mellors; Diane V Havlir; Joseph J Eron; Charles Gonzalez; Douglas McMahon; L Jonas; Anne R Meibohm; Daniel J Holder; William A Schleif; Jon H Condra; Emilio A Emini; Robin Isaacs; Jeffrey A Chodakewitz; Douglas D Richman
Simultaneous vs sequential initiation of therapy with indinavir, zidovudine, and lamivudine for HIV-1 infection: 100-week follow-up.
JAMA : the journal of the American Medical Association 1998;280(1):35-41.
1997: Joseph Wong; Huldrych Günthard; Diane V Havlir; Z Q Zhang; Ashley T Haase; Caroline C Ignacio; S Kwok; Emilio A Emini; Douglas D Richman
Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12574-9.
1997: Roy M Gulick; John W Mellors; Diane V Havlir; Joseph J Eron; Charles Gonzalez; Douglas McMahon; Douglas D Richman; Fred Valentine; L Jonas; Anne R Meibohm; Emilio A Emini; Jeffrey A Chodakewitz
Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy.
The New England journal of medicine 1997;337(11):734-9.
1997: JA Kessler; PM McKenna; Emilio A Emini; C P Chan; M D Patel; S K Gupta; G E Mark; C F Barbas; D R Burton; Anthony J Conley
Recombinant human monoclonal antibody IgG1b12 neutralizes diverse human immunodeficiency virus type 1 primary isolates.
AIDS research and human retroviruses 1997;13(7):575-82.
1996: Jon H Condra; D J Holder; William A Schleif; O M Blahy; R M Danovich; L J Gabryelski; D J Graham; D Laird; J C Quintero; A Rhodes; H L Robbins; E Roth; M Shivaprakash; T Yang; Jeffrey A Chodakewitz; Paul J Deutsch; R Y Leavitt; F E Massari; J W Mellors; K E Squires; R T Steigbigel; H Teppler; Emilio A Emini
Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor.
Journal of virology 1996;70(12):8270-6.
1996: Anthony J Conley; J A Kessler; L J Boots; PM McKenna; William A Schleif; Emilio A Emini; G E Mark; H Katinger; E K Cobb; S M Lunceford; S R Rouse; Krishna K Murthy
The consequence of passive administration of an anti-human immunodeficiency virus type 1 neutralizing monoclonal antibody before challenge of chimpanzees with a primary virus isolate.
Journal of virology 1996;70(10):6751-8.
1996: Emilio A Emini; William A Schleif; Paul J Deutsch; Jon H Condra
In vivo selection of HIV-1 variants with reduced susceptibility to the protease inhibitor L-735,524 and related compounds.
Advances in experimental medicine and biology 1996;394():327-31.
1995: John C Kappes; Michael S Saag; George M Shaw; Beatrice H Hahn; P Chopra; S Chen; Emilio A Emini; R McFarland; L C Yang; M Piatak
Assessment of antiretroviral therapy by plasma viral load testing: standard and ICD HIV-1 p24 antigen and viral RNA (QC-PCR) assays compared.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1995;10(2):139-49.
1995: D W Lineberger; J A Kessler; J A Waterbury; V W Byrnes; F Massari; Schlomo Staszewski; Emilio A Emini
Turnover of circulating virion RNA and of cell-associated viral DNA reflects active viral replication in human immunodeficiency virus type 1-infected individuals.
Journal of virology 1995;69(4):2637-9.
1995: R L LaFemina; P L Graham; K LeGrow; J C Hastings; A Wolfe; S D Young; Emilio A Emini; Daria J Hazuda
Inhibition of human immunodeficiency virus integrase by bis-catechols.
Antimicrobial agents and chemotherapy 1995;39(2):320-4.
1995: X Wei; S K Ghosh; M E Taylor; Victoria A Johnson; Emilio A Emini; Paul J Deutsch; J D Lifson; Sebastian Bonhoeffer; M A Nowak; Beatrice H Hahn
Viral dynamics in human immunodeficiency virus type 1 infection.
Nature 1995;373(6510):117-22.
1995: Emilio A Emini
Resistance to anti-human immunodeficiency virus therapeutic agents.
Advances in experimental medicine and biology 1995;390():187-95.
1994: Anthony J Conley; Miroslaw K Gorny; J A Kessler; L J Boots; M Ossorio-Castro; Scott Koenig; D W Lineberger; Emilio A Emini; C Williams; Susan Zolla-Pazner
Neutralization of primary human immunodeficiency virus type 1 isolates by the broadly reactive anti-V3 monoclonal antibody, 447-52D.
Journal of virology 1994;68(11):6994-7000.
1994: Bruce D Dorsey; R B Levin; S L McDaniel; Joseph P Vacca; James P Guare; Paul L Darke; J A Zugay; Emilio A Emini; William A Schleif; J C Quintero
L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor.
Journal of medicinal chemistry 1994;37(21):3443-51.
1994: Jan Balzarini; Anna Karlsson; Vinod Sardana; Emilio A Emini; María-José Camarasa; E De Clercq
Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C-->C181I)RT HIV-1 mutants.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6599-603.
1994: V W Byrnes; Emilio A Emini; William A Schleif; Jon H Condra; C L Schneider; W J Long; J A Wolfgang; D J Graham; L Gotlib; A J Schlabach
Susceptibilities of human immunodeficiency virus type 1 enzyme and viral variants expressing multiple resistance-engendering amino acid substitutions to reserve transcriptase inhibitors.
Antimicrobial agents and chemotherapy 1994;38(6):1404-7.
1994: Vinod Sardana; J A Wolfgang; C A Veloski; W J Long; K LeGrow; B Wolanski; Emilio A Emini; R L LaFemina
Peptide substrate cleavage specificity of the human cytomegalovirus protease.
The Journal of biological chemistry 1994;269(20):14337-40.
1994: Anthony J Conley; J A Kessler; L J Boots; J S Tung; B A Arnold; Paul M Keller; Alan Shaw; Emilio A Emini
Neutralization of divergent human immunodeficiency virus type 1 variants and primary isolates by IAM-41-2F5, an anti-gp41 human monoclonal antibody.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):3348-52.
1994: Daria J Hazuda; J C Hastings; A L Wolfe; Emilio A Emini
A novel assay for the DNA strand-transfer reaction of HIV-1 integrase.
Nucleic acids research 1994;22(6):1121-2.
1994: Daria J Hazuda; A L Wolfe; J C Hastings; H L Robbins; P L Graham; R L LaFemina; Emilio A Emini
Viral long terminal repeat substrate binding characteristics of the human immunodeficiency virus type 1 integrase.
The Journal of biological chemistry 1994;269(6):3999-4004.
1994: Amos B Smith; Ralph Hirschmann; A Pasternak; R Akaishi; M C Guzman; D R Jones; T P Keenan; Paul A Sprengeler; Paul L Darke; Emilio A Emini
Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport.
Journal of medicinal chemistry 1994;37(2):215-8.
1994: Emilio A Emini; V W Byrnes; Jon H Condra; William A Schleif; Vinod Sardana
The genetic and functional basis of HIV-1 resistance to nonnucleoside reverse transcriptase inhibitors.
Archives of virology. Supplementum 1994;9():11-7.
1993: Michael S Saag; Emilio A Emini; O L Laskin; J Douglas; W I Lapidus; William A Schleif; Richard J Whitley; C Hildebrand; V W Byrnes; John C Kappes
A short-term clinical evaluation of L-697,661, a non-nucleoside inhibitor of HIV-1 reverse transcriptase. L-697,661 Working Group.
The New England journal of medicine 1993;329(15):1065-72.
1993: Emilio A Emini; D J Graham; L Gotlib; Jon H Condra; V W Byrnes; William A Schleif
HIV and multidrug resistance.
Nature 1993;364(6439):679.
1993: Richard L Tolman; M A Bednarek; B A Johnson; W J Leanza; S Marburg; D J Underwood; Emilio A Emini; Anthony J Conley
Cyclic V3-loop-related HIV-1 conjugate vaccines. Synthesis, conformation and immunological properties.
International journal of peptide and protein research 1993;41(5):455-66.
1993: M E Goldman; J A O'Brien; T L Ruffing; William A Schleif; Vinod Sardana; V W Byrnes; Jon H Condra; J M Hoffman; Emilio A Emini
A nonnucleoside reverse transcriptase inhibitor active on human immunodeficiency virus type 1 isolates resistant to related inhibitors.
Antimicrobial agents and chemotherapy 1993;37(5):947-9.
1993: Theresa M Williams; T M Ciccarone; Suzanne C MacTough; C S Rooney; Suresh K Balani; Jon H Condra; Emilio A Emini; M E Goldman; W J Greenlee; L R Kauffman
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Journal of medicinal chemistry 1993;36(9):1291-4.
1993: Arun K Ghosh; W J Thompson; H Y Lee; S P McKee; P M Munson; T T Duong; Paul L Darke; J A Zugay; Emilio A Emini; William A Schleif
Cyclic sulfolanes as novel and high affinity P2 ligands for HIV-1 protease inhibitors.
Journal of medicinal chemistry 1993;36(7):924-7.
1993: Y Yasutomi; Scott Koenig; S S Haun; C Kendall Stover; R K Jackson; P Conard; Anthony J Conley; Emilio A Emini; Thomas R Fuerst; Norman L Letvin
Immunization with recombinant BCG-SIV elicits SIV-specific cytotoxic T lymphocytes in rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(7):3101-7.
1993: Arun K Ghosh; W J Thompson; S P McKee; T T Duong; T A Lyle; J C Chen; Paul L Darke; J A Zugay; Emilio A Emini; William A Schleif
3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors.
Journal of medicinal chemistry 1993;36(2):292-4.
1993: Arun K Ghosh; S P McKee; W M Sanders; Paul L Darke; J A Zugay; Emilio A Emini; William A Schleif; J C Quintero; Joel R Huff; P S Anderson
HIV-1 protease inhibitors: synthesis and biological evaluation of glycopeptidemimetics.
Drug design and discovery 1993;10(1):77-88.
1992: Miroslaw K Gorny; Anthony J Conley; S Karwowska; A Buchbinder; J Y Xu; Emilio A Emini; Scott Koenig; Susan Zolla-Pazner
Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody.
Journal of virology 1992;66(12):7538-42.
1992: R L LaFemina; C L Schneider; H L Robbins; P L Callahan; K LeGrow; E Roth; William A Schleif; Emilio A Emini
Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells.
Journal of virology 1992;66(12):7414-9.
1992: Vinod Sardana; Emilio A Emini; L Gotlib; D J Graham; D W Lineberger; W J Long; A J Schlabach; J A Wolfgang; Jon H Condra
Functional analysis of HIV-1 reverse transcriptase amino acids involved in resistance to multiple nonnucleoside inhibitors.
The Journal of biological chemistry 1992;267(25):17526-30.
1992: Jon H Condra; Emilio A Emini; L Gotlib; D J Graham; A J Schlabach; J A Wolfgang; Richard J Colonno; Vinod Sardana
Identification of the human immunodeficiency virus reverse transcriptase residues that contribute to the activity of diverse nonnucleoside inhibitors.
Antimicrobial agents and chemotherapy 1992;36(7):1441-6.
1992: W J Thompson; P M Fitzgerald; M K Holloway; Emilio A Emini; Paul L Darke; Brian McKeever; William A Schleif; J C Quintero; J A Zugay; Thomas J Tucker
Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents: X-ray crystal structure assisted design.
Journal of medicinal chemistry 1992;35(10):1685-701.
1992: M E Goldman; J A O'Brien; T L Ruffing; J H Nunberg; William A Schleif; J C Quintero; Peter K S Siegl; J M Hoffman; A M Smith; Emilio A Emini
L-696,229 specifically inhibits human immunodeficiency virus type 1 reverse transcriptase and possesses antiviral activity in vitro.
Antimicrobial agents and chemotherapy 1992;36(5):1019-23.
1992: Emilio A Emini; William A Schleif; J H Nunberg; Anthony J Conley; Yasuyuki Eda; Sachio Tokiyoshi; S D Putney; Shuzo Matsushita; K E Cobb; C M Jett
Prevention of HIV-1 infection in chimpanzees by gp120 V3 domain-specific monoclonal antibody.
Nature 1992;355(6362):728-30.
1991: J H Nunberg; William A Schleif; E J Boots; J A O'Brien; J C Quintero; J M Hoffman; Emilio A Emini; M E Goldman
Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors.
Journal of virology 1991;65(9):4887-92.
1991: T A Lyle; C M Wiscount; James P Guare; W J Thompson; P S Anderson; Paul L Darke; Z A Zugay; Emilio A Emini; William A Schleif; J C Qunitero
Benzocycloalkyl amines as novel C-termini for HIV protease inhibitors.
Journal of medicinal chemistry 1991;34(3):1228-30.
1990: Emilio A Emini; William A Schleif; J C Quintero; P G Conard; J W Eichberg; G P Vlasuk; ED Lehman; M A Polokoff; T F Schaeffer; Loren D Schultz
Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 does not elicit protective immunity in chimpanzees.
AIDS research and human retroviruses 1990;6(11):1247-50.
1990: Emilio A Emini; P L Nara; William A Schleif; J A Lewis; J P Davide; D R Lee; J Kessler; S Conley; Shuzo Matsushita; S D Putney
Antibody-mediated in vitro neutralization of human immunodeficiency virus type 1 abolishes infectivity for chimpanzees.
Journal of virology 1990;64(8):3674-8.
1990: M E Goldman; G S Salituro; J A Bowen; J M Williamson; D L Zink; William A Schleif; Emilio A Emini
Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site.
Molecular pharmacology 1990;38(1):20-5.
1989: Emilio A Emini; V Larson; J Eichberg; P Conard; V M Garsky; D R Lee; R W Ellis; W J Miller; C A Anderson; R J Gerety
Protective effect of a synthetic peptide comprising the complete preS2 region of the hepatitis B virus surface protein.
Journal of medical virology 1989;28(1):7-12.
1989: Emilio A Emini; William A Schleif; M Silberklang; D Lehman; R W Ellis
Vero cell-expressed Epstein-Barr virus (EBV) gp350/220 protects marmosets from EBV challenge.
Journal of medical virology 1989;27(2):120-3.
1988: Emilio A Emini; William A Schleif; M E Armstrong; M Silberklang; Loren D Schultz; D Lehman; R Z Maigetter; L F Qualtiere; G R Pearson; R W Ellis
Antigenic analysis of the Epstein-Barr virus major membrane antigen (gp350/220) expressed in yeast and mammalian cells: implications for the development of a subunit vaccine.
Virology 1988;166(2):387-93.
1988: Nancy E Kohl; Emilio A Emini; William A Schleif; L J Davis; J C Heimbach; R A Dixon; E M Scolnick; I S Sigal
Active human immunodeficiency virus protease is required for viral infectivity.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4686-90.
1988: G A Robertson; B M Kostek; William A Schleif; J A Lewis; Emilio A Emini
A microtiter cell-culture assay for the determination of anti-human immunodeficiency virus neutralizing antibody activity.
Journal of virological methods 1988;20(3):195-202.
1988: W J Long; A Palombo; Timothy L Schofield; Emilio A Emini
Effects of culture media on murine hybridomas: definition of optimal conditions for hybridoma viability, cellular proliferation, and antibody production.
Hybridoma 1988;7(1):69-77.
1988: P J Kniskern; A Hagopian; P Burke; N Dunn; Emilio A Emini; W J Miller; S Yamazaki; R W Ellis
A candidate vaccine for hepatitis B containing the complete viral surface protein.
Hepatology (Baltimore, Md.) 1988;8(1):82-7.
1987: Emilio A Emini; Janos Luka; M E Armstrong; P M Keller; R W Ellis; G R Pearson
Identification of an Epstein-Barr virus glycoprotein which is antigenically homologous to the varicella-zoster virus glycoprotein II and the herpes simplex virus glycoprotein B.
Virology 1987;157(2):552-5.
1986: W J Long; K E Shmihluk; P E Gruver; W R McGuire; A Palombo; Emilio A Emini
A voice-entry data management system: application in monoclonal antibody research.
Computer methods and programs in biomedicine 1986;23(3):211-6.
1986: P J Provost; J V Hughes; W J Miller; P A Giesa; F S Banker; Emilio A Emini
An inactivated hepatitis A viral vaccine of cell culture origin.
Journal of medical virology 1986;19(1):23-31.
1986: Emilio A Emini; Janos Luka; M E Armstrong; F S Banker; P J Provost; G R Pearson
Establishment and characterization of a chronic infectious mononucleosislike syndrome in common marmosets.
Journal of medical virology 1986;18(4):369-79.
1986: R L Crowell; A K Field; William A Schleif; W L Long; R J Colonno; J E Mapoles; Emilio A Emini
Monoclonal antibody that inhibits infection of HeLa and rhabdomyosarcoma cells by selected enteroviruses through receptor blockade.
Journal of virology 1986;57(2):438-45.
1986: W J Long; W McGuire; A Palombo; Emilio A Emini
Enhancing the establishment efficiency of hybridoma cells. Use of irradiated human diploid fibroblast feeder layers.
Journal of immunological methods 1986;86(1):89-93.
1985: Emilio A Emini; William A Schleif; B A Jameson; E Wimmer
The immune response to poliovirus-specific synthetic peptides: effects of adjuvants and test animal species.
Journal of virological methods 1985;10(2):163-70.
1985: Emilio A Emini; William A Schleif; R J Colonno; E Wimmer
Antigenic conservation and divergence between the viral-specific proteins of poliovirus type 1 and various picornaviruses.
Virology 1985;140(1):13-20.