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Scott Emr

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Living Beings

Saccharomyces cerevisiae

Chemicals & Drugs

Anatomy

Physiology

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Publications

TOP 3
Andrew G Manford; Christopher J Stefan; Helen L Yuan; Jason A MacGurn; Scott D Emr
ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology.
William Mike Henne; Yingying Zhao; Nicholas J Buchkovich; Scott D Emr
The endosomal sorting complex ESCRT-II mediates the assembly and architecture of ESCRT-III helices.
Yading Ling; Jason A MacGurn; Christopher J Stefan; Anjon Audhya; Scott D Emr
The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P₂ synthesis.

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All Publications

2012: Andrew G Manford; Christopher J Stefan; Helen L Yuan; Jason A MacGurn; Scott D Emr
ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology.
Developmental cell 2012;23(6):1129-40.
2012: William Mike Henne; Yingying Zhao; Nicholas J Buchkovich; Scott D Emr
The endosomal sorting complex ESCRT-II mediates the assembly and architecture of ESCRT-III helices.
Cell 2012;151(2):356-71.
2012: Yading Ling; Jason A MacGurn; Christopher J Stefan; Anjon Audhya; Scott D Emr
The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P₂ synthesis.
The EMBO journal 2012;31(13):2882-94.
2012: Chris MacDonald; Nicholas J Buchkovich; Scott D Emr; Daniel K Stringer; Robert C Piper
Cargo ubiquitination is essential for multivesicular body intralumenal vesicle formation.
EMBO reports 2012;13(4):331-8.
2012: Jason A MacGurn; Pi-Chiang Hsu; Scott D Emr
Ubiquitin and membrane protein turnover: from cradle to grave.
Annual review of biochemistry 2012;81():231-59.
2011: Lena Karotki; Nevan J Krogan; Robyn Roth; Christopher J Stefan; Michal A Surma; Scott D Emr; Kay Grünewald; John Edward Heuser; Juha Huiskonen; Natasza E Ziółkowska; Tobias C Walther
Eisosome proteins assemble into a membrane scaffold.
The Journal of cell biology 2011;195(5):889-902.
2011: Jason A MacGurn; Marcus B Smolka; Pi-Chiang Hsu; Scott D Emr
TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor.
Cell 2011;147(5):1104-17.
2011: Yufeng Shi; Christopher J Stefan; David Teis; Sarah M Rue; Scott D Emr
Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway.
Molecular biology of the cell 2011;22(21):4093-107.
2011: Michael A McMurray; Charles (Greg) Odorizzi; Christopher J Stefan; Scott D Emr; Megan Wemmer; Jeremy Thorner
Genetic interactions with mutations affecting septin assembly reveal ESCRT functions in budding yeast cytokinesis.
Biological chemistry 2011;392(8-9):699-712.
2011: William M Henne; Nicholas J Buchkovich; Scott D Emr
The ESCRT pathway.
Developmental cell 2011;21(1):77-91.
2011: Bong-Kwan Han; Scott D Emr
Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1.
Genes & development 2011;25(9):984-95.
2011: Christopher J Stefan; Andrew G Manford; Daniel Baird; Jason Yamada-Hanff; Yuxin Mao; Scott D Emr
Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites.
Cell 2011;144(3):389-401.
2010: Lindsay S Garrenton; Christopher J Stefan; Michael A McMurray; Scott D Emr; Jeremy Thorner
Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(26):11805-10.
2010: Andrew Manford; Tian Xia; Ajay Kumar Saxena; Christopher Stefan; Fenghua Hu; Scott D Emr; Yuxin Mao
Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function.
The EMBO journal 2010;29(9):1489-98.
2010: David Teis; Suraj Saksena; Bret L Judson; Scott D Emr
ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation.
The EMBO journal 2010;29(5):871-83.
2009: John H Tran; Ching-Jen Chen; Scott D Emr; Randy Schekman
Cargo sorting into multivesicular bodies in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(41):17395-400.
2009: David Teis; Suraj Saksena; Scott D Emr
SnapShot: the ESCRT machinery.
Cell 2009;137(1):182-182.e1.
2009: Suraj Saksena; Scott D Emr
ESCRTs and human disease.
Biochemical Society transactions 2009;37(Pt 1):167-72.
2009: Suraj Saksena; Judit Wahlman; David Teis; Arthur E Johnson; Scott D Emr
Functional reconstitution of ESCRT-III assembly and disassembly.
Cell 2009;136(1):97-109.
2008: Charles H Lin; Jason A MacGurn; Tony Chu; Christopher J Stefan; Scott D Emr
Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface.
Cell 2008;135(4):714-25.
2008: David Teis; Suraj Saksena; Scott D Emr
Ordered assembly of the ESCRT-III complex on endosomes is required to sequester cargo during MVB formation.
Developmental cell 2008;15(4):578-89.
2008: Roberto J Botelho; Jem A Efe; David Teis; Scott D Emr
Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase.
Molecular biology of the cell 2008;19(10):4273-86.
2008: Sara Ghazi-Tabatabai; Suraj Saksena; Judith M Short; Ajaybabu V Pobbati; Dmitry B Veprintsev; R Anthony Crowther; Scott D Emr; Edward H Egelman; Roger L Williams
Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.
Structure (London, England : 1993) 2008;16(9):1345-56.
2008: Sarah M. Rue; Sara Mattei; Suraj Saksena; Scott D Emr
Novel Ist1-Did2 complex functions at a late step in multivesicular body sorting.
Molecular biology of the cell 2008;19(2):475-84.
2007: Suraj Saksena; Ji Sun; Tony Chu; Scott D Emr
ESCRTing proteins in the endocytic pathway.
Trends in biochemical sciences 2007;32(12):561-73.
2007: Jem A Efe; Roberto J Botelho; Scott D Emr
Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate.
Molecular biology of the cell 2007;18(11):4232-44.
2007: Takayuki Obita; Suraj Saksena; Sara Ghazi-Tabatabai; David J Gill; Olga Perisic; Scott D Emr; Roger L Williams
Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4.
Nature 2007;449(7163):735-9.
2007: David J Gill; Hsiangling Teo; Ji Sun; Olga Perisic; Dmitry B Veprintsev; Scott D Emr; Roger L Williams
Structural insight into the ESCRT-I/-II link and its role in MVB trafficking.
The EMBO journal 2007;26(2):600-12.
2007: David J Gill; Hsiangling Teo; Ji Sun; Olga Perisic; Dmitry B Veprintsev; Yvonne Vallis; Scott D Emr; Roger L Williams
Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies.
Biochemical Society symposium 2007;(74):47-57.
2006: Tony Chu; Ji Sun; Suraj Saksena; Scott D Emr
New component of ESCRT-I regulates endosomal sorting complex assembly.
The Journal of cell biology 2006;175(5):815-23.
2006: Nadya Morozova; Yongheng Liang; Andrei A Tokarev; Shu H Chen; Randal Cox; Jelena Andrejic; Zhanna Lipatova; Vicki A Sciorra; Scott D Emr; Nava Segev
TRAPPII subunits are required for the specificity switch of a Ypt-Rab GEF.
Nature cell biology 2006;8(11):1263-9.
2006: Mitsuaki Tabuchi; Anjon Audhya; Ainslie B Parsons; Charles Boone; Scott D Emr
The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation.
Molecular and cellular biology 2006;26(15):5861-75.
2006: Michael S Kostelansky; Ji Sun; Sangho Lee; Jaewon Kim; Rodolfo Ghirlando; Aitor Hierro; Scott D Emr; James H Hurley
Structural and functional organization of the ESCRT-I trafficking complex.
Cell 2006;125(1):113-26.
2006: Hsiangling Teo; David J Gill; Ji Sun; Olga Perisic; Dmitry B Veprintsev; Yvonne Vallis; Scott D Emr; Roger L Williams
ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes.
Cell 2006;125(1):99-111.
2006: James H Hurley; Scott D Emr
The ESCRT complexes: structure and mechanism of a membrane-trafficking network.
Annual review of biophysics and biomolecular structure 2006;35():277-98.
2005: William R Parrish; Christopher J Stefan; Scott D Emr
PtdIns(3)P accumulation in triple lipid-phosphatase-deletion mutants triggers lethal hyperactivation of the Rho1p/Pkc1p cell-integrity MAP kinase pathway.
Journal of cell science 2005;118(Pt 23):5589-601.
2005: Jem A Efe; Fabienne Plattner; Nicolas Hulo; Dieter Kressler; Scott D Emr; Olivier Deloche
Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-to-vacuole transport pathway and is required for Golgi homeostasis.
Journal of cell science 2005;118(Pt 20):4751-64.
2005: Jem A Efe; Roberto J Botelho; Scott D Emr
The Fab1 phosphatidylinositol kinase pathway in the regulation of vacuole morphology.
Current opinion in cell biology 2005;17(4):402-8.
2005: Christopher J Stefan; Steven M Padilla; Anjon Audhya; Scott D Emr
The phosphoinositide phosphatase Sjl2 is recruited to cortical actin patches in the control of vesicle formation and fission during endocytosis.
Molecular and cellular biology 2005;25(8):2910-23.
2005: Nadim Shohdy; Jem A Efe; Scott D Emr; Howard A Shuman
Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(13):4866-71.
2005: Vicki A Sciorra; Anjon Audhya; Ainslie B Parsons; Nava Segev; Charles Boone; Scott D Emr
Synthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway.
Molecular biology of the cell 2005;16(2):776-93.
2004: Aimee L Miller; Mythili Suntharalingam; Sylvia L Johnson; Anjon Audhya; Scott D Emr; Susan R Wente
Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway.
The Journal of biological chemistry 2004;279(49):51022-32.
2004: Anjon Audhya; Robbie Loewith; Ainslie B Parsons; Lu Gao; Mitsuaki Tabuchi; Huilin Zhou; Charles Boone; Michael N Hall; Scott D Emr
Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.
The EMBO journal 2004;23(19):3747-57.
2004: Aitor Hierro; Ji Sun; Alexander S Rusnak; Jaewon Kim; Gali Prag; Scott D Emr; James H Hurley
Structure of the ESCRT-II endosomal trafficking complex.
Nature 2004;431(7005):221-5.
2004: William R Parrish; Christopher J Stefan; Scott D Emr
Essential role for the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2p and Sjl3p in regulation of phosphatidylinositol 3-phosphate in yeast.
Molecular biology of the cell 2004;15(8):3567-79.
2004: Steven L Alam; Ji Sun; Marielle Payne; Brett D Welch; B Kelly Blake; Darrell R Davis; Hemmo H Meyer; Scott D Emr; Wesley I Sundquist
Ubiquitin interactions of NZF zinc fingers.
The EMBO journal 2004;23(7):1411-21.
2004: Jong W Yu; Jeannine M Mendrola; Anjon Audhya; Shaneen Singh; David Keleti; Daryll B DeWald; Diana Murray; Scott D Emr; Mark A Lemmon
Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains.
Molecular cell 2004;13(5):677-88.
2004: David J Katzmann; Srimonti Sarkar; Tony Chu; Anjon Audhya; Scott D Emr
Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S.
Molecular biology of the cell 2004;15(2):468-80.
2004: Simon A Rudge; Deborah M Anderson; Scott D Emr
Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase.
Molecular biology of the cell 2004;15(1):24-36.
2003: Daniel J Klionsky; James M Cregg; William A Dunn; Scott D Emr; Yasuyoshi Sakai; Ignacio V Sandoval; Andriy A Sibirny; Suresh Subramani; Michael Thumm; Marten Veenhuis; Yoshinori Ohsumi
A unified nomenclature for yeast autophagy-related genes.
Developmental cell 2003;5(4):539-45.
2003: Anjon Audhya; Scott D Emr
Regulation of PI4,5P2 synthesis by nuclear-cytoplasmic shuttling of the Mss4 lipid kinase.
The EMBO journal 2003;22(16):4223-36.
2003: David J Katzmann; Christopher J Stefan; Markus Babst; Scott D Emr
Vps27 recruits ESCRT machinery to endosomes during MVB sorting.
The Journal of cell biology 2003;162(3):413-23.
2003: Charles (Greg) Odorizzi; David J Katzmann; Markus Babst; Anjon Audhya; Scott D Emr
Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae.
Journal of cell science 2003;116(Pt 10):1893-903.
2002: Gil-Soo Han; Anjon Audhya; Daniel J Markley; Scott D Emr; George M Carman
The Saccharomyces cerevisiae LSB6 gene encodes phosphatidylinositol 4-kinase activity.
The Journal of biological chemistry 2002;277(49):47709-18.
2002: David J Katzmann; Charles (Greg) Odorizzi; Scott D Emr
Receptor downregulation and multivesicular-body sorting.
Nature reviews. Molecular cell biology 2002;3(12):893-905.
2002: Patricie Burda; Steven M Padilla; Srimonti Sarkar; Scott D Emr
Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase.
Journal of cell science 2002;115(Pt 20):3889-900.
2002: Vivek Malhotra; Scott D Emr
Rothman and Schekman SNAREd by Lasker for trafficking.
Cell 2002;111(1):1-3.
2002: Andrew E Wurmser; Scott D Emr
Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy.
The Journal of cell biology 2002;158(4):761-72.
2002: Daniel C Nice; Trey K Sato; Per E Stromhaug; Scott D Emr; Daniel J Klionsky
Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy.
The Journal of biological chemistry 2002;277(33):30198-207.
2002: Markus Babst; David J Katzmann; William B Snyder; Beverly Wendland; Scott D Emr
Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body.
Developmental cell 2002;3(2):283-9.
2002: Markus Babst; David J Katzmann; Eden J Estepa-Sabal; Timo Meerloo; Scott D Emr
Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting.
Developmental cell 2002;3(2):271-82.
2002: Qi Zhong; Cheri S Lazar; Hélène Tronchère; Trey K Sato; Timo Meerloo; Michele Yeo; Zhou Songyang; Scott D Emr; Gordon N Gill
Endosomal localization and function of sorting nexin 1.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6767-72.
2002: Anjon Audhya; Scott D Emr
Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade.
Developmental cell 2002;2(5):593-605.
2002: Susan C Shih; David J Katzmann; Joshua Schnell; Myra Sutanto; Scott D Emr; Linda Hicke
Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis.
Nature cell biology 2002;4(5):389-93.
2002: Jonathan D Gary; Trey K Sato; Christopher J Stefan; Cecilia J Bonangelino; Lois S Weisman; Scott D Emr
Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.
Molecular biology of the cell 2002;13(4):1238-51.
2002: Cecilia J Bonangelino; Johnathan J Nau; Jason E Duex; Mikala Brinkman; Andrew E Wurmser; Jonathan D Gary; Scott D Emr; Lois S Weisman
Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.
The Journal of cell biology 2002;156(6):1015-28.
2002: Christopher J Stefan; Anjon Audhya; Scott D Emr
The yeast synaptojanin-like proteins control the cellular distribution of phosphatidylinositol (4,5)-bisphosphate.
Molecular biology of the cell 2002;13(2):542-57.
2001: Trey K Sato; Michael Overduin; Scott D Emr
Location, location, location: membrane targeting directed by PX domains.
Science (New York, N.Y.) 2001;294(5548):1881-5.
2001: M Foti; Anjon Audhya; Scott D Emr
Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology.
Molecular biology of the cell 2001;12(8):2396-411.
2001: Anne Simonsen; Andrew E Wurmser; Scott D Emr; Harald Stenmark
The role of phosphoinositides in membrane transport.
Current opinion in cell biology 2001;13(4):485-92.
2001: David J Katzmann; Markus Babst; Scott D Emr
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.
Cell 2001;106(2):145-55.
2001: MR Peterson; Scott D Emr
The class C Vps complex functions at multiple stages of the vacuolar transport pathway.
Traffic (Copenhagen, Denmark) 2001;2(7):476-86.
2001: T Darsow; David J Katzmann; CR Cowles; Scott D Emr
Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and interaction with AP-3 through two distinct domains.
Molecular biology of the cell 2001;12(1):37-51.
2000: Daniel J Klionsky; Scott D Emr
Autophagy as a regulated pathway of cellular degradation.
Science (New York, N.Y.) 2000;290(5497):1717-21.
2000: Andrew E Wurmser; Trey K Sato; Scott D Emr
New component of the vacuolar class C-Vps complex couples nucleotide exchange on the Ypt7 GTPase to SNARE-dependent docking and fusion.
The Journal of cell biology 2000;151(3):551-62.
2000: Trey K Sato; Peter Rehling; MR Peterson; Scott D Emr
Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion.
Molecular cell 2000;6(3):661-71.
2000: Anjon Audhya; M Foti; Scott D Emr
Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics.
Molecular biology of the cell 2000;11(8):2673-89.
2000: Charles (Greg) Odorizzi; Markus Babst; Scott D Emr
Phosphoinositide signaling and the regulation of membrane trafficking in yeast.
Trends in biochemical sciences 2000;25(5):229-35.
2000: Markus Babst; Charles (Greg) Odorizzi; E J Estepa; Scott D Emr
Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking.
Traffic (Copenhagen, Denmark) 2000;1(3):248-58.
2000: T Darsow; Charles (Greg) Odorizzi; Scott D Emr
Invertase fusion proteins for analysis of protein trafficking in yeast.
Methods in enzymology 2000;327():95-106.
1999: H Abeliovich; T Darsow; Scott D Emr
Cytoplasm to vacuole trafficking of aminopeptidase I requires a t-SNARE-Sec1p complex composed of Tlg2p and Vps45p.
The EMBO journal 1999;18(21):6005-16.
1999: Peter Rehling; T Darsow; David J Katzmann; Scott D Emr
Formation of AP-3 transport intermediates requires Vps41 function.
Nature cell biology 1999;1(6):346-53.
1999: Andrew E Wurmser; Jonathan D Gary; Scott D Emr
Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways.
The Journal of biological chemistry 1999;274(14):9129-32.
1999: EC Gaynor; G Mondésert; Stephen J Grimme; Steven I Reed; Peter Orlean; Scott D Emr
MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast.
Molecular biology of the cell 1999;10(3):627-48.
1999: MR Peterson; Christopher G Burd; Scott D Emr
Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome.
Current biology : CB 1999;9(3):159-62.
1998: Charles (Greg) Odorizzi; Markus Babst; Scott D Emr
Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body.
Cell 1998;95(6):847-58.
1998: Jonathan D Gary; Andrew E Wurmser; Cecilia J Bonangelino; Lois S Weisman; Scott D Emr
Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis.
The Journal of cell biology 1998;143(1):65-79.
1998: Christopher G Burd; Markus Babst; Scott D Emr
Novel pathways, membrane coats and PI kinase regulation in yeast lysosomal trafficking.
Seminars in cell & developmental biology 1998;9(5):527-33.
1998: Andrew E Wurmser; Scott D Emr
Phosphoinositide signaling and turnover: PtdIns(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities.
The EMBO journal 1998;17(17):4930-42.
1998: Trey K Sato; T Darsow; Scott D Emr
Vam7p, a SNAP-25-like molecule, and Vam3p, a syntaxin homolog, function together in yeast vacuolar protein trafficking.
Molecular and cellular biology 1998;18(9):5308-19.
1998: T Darsow; Christopher G Burd; Scott D Emr
Acidic di-leucine motif essential for AP-3-dependent sorting and restriction of the functional specificity of the Vam3p vacuolar t-SNARE.
The Journal of cell biology 1998;142(4):913-22.
1998: EC Gaynor; T R Graham; Scott D Emr
COPI in ER/Golgi and intra-Golgi transport: do yeast COPI mutants point the way?
Biochimica et biophysica acta 1998;1404(1-2):33-51.
1998: M N Seaman; JM McCaffery; Scott D Emr
A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast.
The Journal of cell biology 1998;142(3):665-81.
1998: Charles (Greg) Odorizzi; CR Cowles; Scott D Emr
The AP-3 complex: a coat of many colours.
Trends in cell biology 1998;8(7):282-8.
1998: Christopher G Burd; Scott D Emr
Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains.
Molecular cell 1998;2(1):157-62.
1998: Markus Babst; Beverly Wendland; E J Estepa; Scott D Emr
The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function.
The EMBO journal 1998;17(11):2982-93.
1998: EC Gaynor; C Y Chen; Scott D Emr; T R Graham
ARF is required for maintenance of yeast Golgi and endosome structure and function.
Molecular biology of the cell 1998;9(3):653-70.
1997: S E Rieder; Scott D Emr
A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole.
Molecular biology of the cell 1997;8(11):2307-27.
1997: CR Cowles; Charles (Greg) Odorizzi; G S Payne; Scott D Emr
The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole.
Cell 1997;91(1):109-18.
1997: T Darsow; S E Rieder; Scott D Emr
A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole.
The Journal of cell biology 1997;138(3):517-29.
1997: Christopher G Burd; M Peterson; CR Cowles; Scott D Emr
A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast.
Molecular biology of the cell 1997;8(6):1089-104.
1997: Derek Radisky; W B Snyder; Scott D Emr; Jerry Kaplan
Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(11):5662-6.
1997: CR Cowles; W B Snyder; Christopher G Burd; Scott D Emr
Novel Golgi to vacuole delivery pathway in yeast: identification of a sorting determinant and required transport component.
The EMBO journal 1997;16(10):2769-82.
1997: Markus Babst; T K Sato; L M Banta; Scott D Emr
Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p.
The EMBO journal 1997;16(8):1820-31.
1997: M N Seaman; E G Marcusson; J L Cereghino; Scott D Emr
Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products.
The Journal of cell biology 1997;137(1):79-92.
1997: EC Gaynor; Scott D Emr
COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants.
The Journal of cell biology 1997;136(4):789-802.
1996: Bruce F Horazdovsky; CR Cowles; P Mustol; M Holmes; Scott D Emr
A novel RING finger protein, Vps8p, functionally interacts with the small GTPase, Vps21p, to facilitate soluble vacuolar protein localization.
The Journal of biological chemistry 1996;271(52):33607-15.
1996: B Wendland; J M McCaffery; Q Xiao; Scott D Emr
A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15.
The Journal of cell biology 1996;135(6 Pt 1):1485-500.
1996: M N Seaman; Christopher G Burd; Scott D Emr
Receptor signalling and the regulation of endocytic membrane transport.
Current opinion in cell biology 1996;8(4):549-56.
1996: S E Rieder; L M Banta; K Köhrer; J M McCaffery; Scott D Emr
Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant.
Molecular biology of the cell 1996;7(6):985-99.
1996: Christopher G Burd; P A Mustol; P V Schu; Scott D Emr
A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins.
Molecular and cellular biology 1996;16(5):2369-77.
1995: K Takegawa; Daryll B DeWald; Scott D Emr
Schizosaccharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology.
Journal of cell science 1995;108 ( Pt 12)():3745-56.
1995: K Zhou; K Takegawa; Scott D Emr; Richard A Firtel
A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development.
Molecular and cellular biology 1995;15(10):5645-56.
1995: J L Cereghino; E G Marcusson; Scott D Emr
The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization.
Molecular biology of the cell 1995;6(9):1089-102.
1995: Bruce F Horazdovsky; Daryll B DeWald; Scott D Emr
Protein transport to the yeast vacuole.
Current opinion in cell biology 1995;7(4):544-51.
1995: J H Stack; Daryll B DeWald; K Takegawa; Scott D Emr
Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast.
The Journal of cell biology 1995;129(2):321-34.
1995: Thomas Vida; Scott D Emr
A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast.
The Journal of cell biology 1995;128(5):779-92.
1995: J H Stack; P K Herman; Daryll B DeWald; E G Marcusson; J Lin Cereghino; Bruce F Horazdovsky; Scott D Emr
Novel protein kinase/phosphatidylinositol 3-kinase complex essential for receptor-mediated protein sorting to the vacuole in yeast.
Cold Spring Harbor symposia on quantitative biology 1995;60():157-70.
1995: J H Stack; Bruce F Horazdovsky; Scott D Emr
Receptor-mediated protein sorting to the vacuole in yeast: roles for a protein kinase, a lipid kinase and GTP-binding proteins.
Annual review of cell and developmental biology 1995;11():1-33.
1994: J H Stack; Scott D Emr
Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities.
The Journal of biological chemistry 1994;269(50):31552-62.
1994: CR Cowles; Scott D Emr; Bruce F Horazdovsky
Mutations in the VPS45 gene, a SEC1 homologue, result in vacuolar protein sorting defects and accumulation of membrane vesicles.
Journal of cell science 1994;107 ( Pt 12)():3449-59.
1994: P Welters; K Takegawa; Scott D Emr; Maarten J Chrispeels
AtVPS34, a phosphatidylinositol 3-kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11398-402.
1994: EC Gaynor; S te Heesen; T R Graham; M Aebi; Scott D Emr
Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast.
The Journal of cell biology 1994;127(3):653-65.
1994: E G Marcusson; Bruce F Horazdovsky; J L Cereghino; E Gharakhanian; Scott D Emr
The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene.
Cell 1994;77(4):579-86.
1994: Bruce F Horazdovsky; G R Busch; Scott D Emr
VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins.
The EMBO journal 1994;13(6):1297-309.
1993: J H Stack; Scott D Emr
Genetic and biochemical studies of protein sorting to the yeast vacuole.
Current opinion in cell biology 1993;5(4):641-6.
1993: Thomas Vida; G Huyer; Scott D Emr
Yeast vacuolar proenzymes are sorted in the late Golgi complex and transported to the vacuole via a prevacuolar endosome-like compartment.
The Journal of cell biology 1993;121(6):1245-56.
1993: J H Stack; P K Herman; P V Schu; Scott D Emr
A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole.
The EMBO journal 1993;12(5):2195-204.
1993: P V Schu; K Takegawa; M J Fry; J H Stack; M D Waterfield; Scott D Emr
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting.
Science (New York, N.Y.) 1993;260(5104):88-91.
1993: B F Horazdovsky; Scott D Emr
The VPS16 gene product associates with a sedimentable protein complex and is essential for vacuolar protein sorting in yeast.
The Journal of biological chemistry 1993;268(7):4953-62.
1993: T R Graham; P A Scott; Scott D Emr
Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway.
The EMBO journal 1993;12(3):869-77.
1993: K Köhrer; Scott D Emr
The yeast VPS17 gene encodes a membrane-associated protein required for the sorting of soluble vacuolar hydrolases.
The Journal of biological chemistry 1993;268(1):559-69.
1992: P K Herman; J H Stack; Scott D Emr
An essential role for a protein and lipid kinase complex in secretory protein sorting.
Trends in cell biology 1992;2(12):363-8.
1992: G Paravicini; B F Horazdovsky; Scott D Emr
Alternative pathways for the sorting of soluble vacuolar proteins in yeast: a vps35 null mutant missorts and secretes only a subset of vacuolar hydrolases.
Molecular biology of the cell 1992;3(4):415-27.
1991: J S Robinson; T R Graham; Scott D Emr
A putative zinc finger protein, Saccharomyces cerevisiae Vps18p, affects late Golgi functions required for vacuolar protein sorting and efficient alpha-factor prohormone maturation.
Molecular and cellular biology 1991;11(12):5813-24.
1991: P K Herman; J H Stack; Scott D Emr
A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery.
The EMBO journal 1991;10(13):4049-60.
1991: T R Graham; Scott D Emr
Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant.
The Journal of cell biology 1991;114(2):207-18.
1991: Elliot Altman; C A Kumamoto; Scott D Emr
Heat-shock proteins can substitute for SecB function during protein export in Escherichia coli.
The EMBO journal 1991;10(2):239-45.
1991: P K Herman; J H Stack; J A DeModena; Scott D Emr
A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole.
Cell 1991;64(2):425-37.
1991: Thomas Vida; P K Herman; Scott D Emr; T R Graham
Compartmentalized transport, modification, and sorting of yeast vacuolar hydrolases.
Biomedica biochimica acta 1991;50(4-6):413-20.
1990: Thomas Vida; T R Graham; Scott D Emr
In vitro reconstitution of intercompartmental protein transport to the yeast vacuole.
The Journal of cell biology 1990;111(6 Pt 2):2871-84.
1990: P K Herman; Scott D Emr
Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae.
Molecular and cellular biology 1990;10(12):6742-54.
1990: Elliot Altman; Scott D Emr; C A Kumamoto
The presence of both the signal sequence and a region of mature LamB protein is required for the interaction of LamB with the export factor SecB.
The Journal of biological chemistry 1990;265(30):18154-60.
1990: Elliot Altman; Vytas A Bankaitis; Scott D Emr
Characterization of a region in mature LamB protein that interacts with a component of the export machinery of Escherichia coli.
The Journal of biological chemistry 1990;265(30):18148-53.
1990: Daniel J Klionsky; P K Herman; Scott D Emr
The fungal vacuole: composition, function, and biogenesis.
Microbiological reviews 1990;54(3):266-92.
1990: L M Banta; Thomas Vida; P K Herman; Scott D Emr
Characterization of yeast Vps33p, a protein required for vacuolar protein sorting and vacuole biogenesis.
Molecular and cellular biology 1990;10(9):4638-49.
1990: Daniel J Klionsky; Scott D Emr
A new class of lysosomal/vacuolar protein sorting signals.
The Journal of biological chemistry 1990;265(10):5349-52.
1989: Daniel J Klionsky; Scott D Emr
Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase.
The EMBO journal 1989;8(8):2241-50.
1989: D M Bedwell; Scott A Strobel; Kyuson Yun; G D Jongeward; Scott D Emr
Sequence and structural requirements of a mitochondrial protein import signal defined by saturation cassette mutagenesis.
Molecular and cellular biology 1989;9(3):1014-25.
1988: J S Robinson; Daniel J Klionsky; L M Banta; Scott D Emr
Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.
Molecular and cellular biology 1988;8(11):4936-48.
1988: K A Eakle; M Bernstein; Scott D Emr
Characterization of a component of the yeast secretion machinery: identification of the SEC18 gene product.
Molecular and cellular biology 1988;8(10):4098-109.
1988: L M Banta; J S Robinson; Daniel J Klionsky; Scott D Emr
Organelle assembly in yeast: characterization of yeast mutants defective in vacuolar biogenesis and protein sorting.
The Journal of cell biology 1988;107(4):1369-83.
1988: Daniel J Klionsky; L M Banta; Scott D Emr
Intracellular sorting and processing of a yeast vacuolar hydrolase: proteinase A propeptide contains vacuolar targeting information.
Molecular and cellular biology 1988;8(5):2105-16.
1987: D M Bedwell; Daniel J Klionsky; Scott D Emr
The yeast F1-ATPase beta subunit precursor contains functionally redundant mitochondrial protein import information.
Molecular and cellular biology 1987;7(11):4038-47.