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Mordechai Aboud

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Cell Transformation, Viral

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Ammar Abou-Kandil; Rachel Chamias; W T Godbey; Mahmoud Huleihel; Mordechai Aboud
Differential role of PKC-induced c-Jun in HTLV-1 LTR activation by 12-O-tetradecanoylphorbol-13-acetate in different human T-cell lines.
Ammar Abou-Kandil; Rachel Chamias; W T Godbey; Mahmoud Huleihel; Mordechai Aboud
Role of caspase 9 in activation of HTLV-1 LTR expression by DNA damaging agents.
Rachel Chamias; Mahmoud Huleihel; Mordechai Aboud
The mechanism of HTLV-1 LTR activation by TPA varies in different human T-cell lines: role of specific PKC isoforms.

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All Publications

2012: Ammar Abou-Kandil; Rachel Chamias; W T Godbey; Mahmoud Huleihel; Mordechai Aboud
Differential role of PKC-induced c-Jun in HTLV-1 LTR activation by 12-O-tetradecanoylphorbol-13-acetate in different human T-cell lines.
PloS one 2012;7(1):e29934.
2011: Ammar Abou-Kandil; Rachel Chamias; W T Godbey; Mahmoud Huleihel; Mordechai Aboud
Role of caspase 9 in activation of HTLV-1 LTR expression by DNA damaging agents.
Cell cycle (Georgetown, Tex.) 2011;10(19):3337-45.
2010: Rachel Chamias; Mahmoud Huleihel; Mordechai Aboud
The mechanism of HTLV-1 LTR activation by TPA varies in different human T-cell lines: role of specific PKC isoforms.
Leukemia research 2010;34(1):93-9.
2008: Inbal Azran-Shaish; Yulia Tabakin-Fix; Mahmoud Huleihel; Mary Bakhanashvili; Mordechai Aboud
HTLV-1 tax-induced NF-kappaB activation is synergistically enhanced by 12-O-tetradecanoylphorbol-13-acetate: mechanism and implications for Tax oncogenicity.
Journal of molecular medicine (Berlin, Germany) 2008;86(7):799-814.
2008: Yana Schavinsky-Khrapunsky; Esther Priel; Mordechai Aboud
Dose-dependent dual effect of HTLV-1 tax oncoprotein on p53-dependent nucleotide excision repair in human T-cells.
International journal of cancer. Journal international du cancer 2008;122(2):305-16.
2006: Yulia Tabakin-Fix; Inbal Azran; Yana Schavinky-Khrapunsky; Oren Levy; Mordechai Aboud
Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications.
Carcinogenesis 2006;27(4):673-81.
2005: Inbal Azran; Kuan-Teh Jeang; Mordechai Aboud
High levels of cytoplasmic HTLV-1 Tax mutant proteins retain a Tax-NF-kappaB-CBP ternary complex in the cytoplasm.
Oncogene 2005;24(28):4521-30.
2004: Inbal Azran; Yana Schavinsky-Khrapunsky; Esther Priel; Mahmoud Huleihel; Mordechai Aboud
Implications of the evolution pattern of human T-cell leukemia retroviruses on their pathogenic virulence (Review).
International journal of molecular medicine 2004;14(5):909-15.
2004: Yulia Tabakin-Fix; Mahmoud Huleihel; Mordechai Aboud
Activation of simian virus 40 promoter by HTLV-I Tax protein: role of NF-kappaB and CBP.
Biochemical and biophysical research communications 2004;318(4):1052-6.
2004: Inbal Azran; Yana Schavinsky-Khrapunsky; Mordechai Aboud
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
Retrovirology 2004;1():20.
2003: Yana Schavinsky-Khrapunsky; Mahmoud Huleihel; Mordechai Aboud; Amram Torgeman
Role of protein kinase C and the Sp1-p53 complex in activation of p21(WAF-1) expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells.
Oncogene 2003;22(34):5315-24.
2003: Yana Schavinsky-Khrapunsky; Mahmoud Huleihel; Mordechai Aboud; Amram Torgeman
TPA activates p21WAF-1 promoter in human T-cells through its second most upstream Sp1 site.
Biochemical and biophysical research communications 2003;304(4):696-700.
2003: Yana Schavinsky-Khrapunsky; Evgenia Gold; Zahi Ben-Aroya; Amram Torgeman; Mordechai Aboud; Mahmoud Huleihel
Activation of HTLV-I long terminal repeat by apoptosis inducing agents: mechanism and implications for HTLV-I pathogenicity (review).
International journal of molecular medicine 2003;11(1):3-11.
2001: Amram Torgeman; Zahi Ben-Aroya; A Grunspan; E Zelin; E Butovsky; Mordechai Hallak; Martin Löchelt; Rolf M Flügel; E Livneh; Marina Wolfson; I Kedar; Mordechai Aboud
Activation of HTLV-I long terminal repeat by stress-inducing agents and protection of HTLV-I-infected T-cells from apoptosis by the viral tax protein.
Experimental cell research 2001;271(1):169-79.
2001: Amram Torgeman; Nirit Mor-Vaknin; E Zelin; Zahi Ben-Aroya; Martin Löchelt; Rolf M Flügel; Mordechai Aboud
Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C.
Virology 2001;281(1):10-20.
2000: A Wagner; A Doerks; Mordechai Aboud; Angel Alonso; T Tokino; Rolf M Flügel; Martin Löchelt
Induction of cellular genes is mediated by the Bel1 transactivator in foamy virus-infected human cells.
Journal of virology 2000;74(10):4441-7.
1999: Amram Torgeman; Nirit Mor-Vaknin; Mordechai Aboud
Sp1 is involved in a protein kinase C-independent activation of human T cell leukemia virus type I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate.
Virology 1999;254(2):279-87.
1998: H Turgeman; Mordechai Aboud
Evidence that protein kinase A activity is required for the basal and tax-stimulated transcriptional activity of human T-cell leukemia virus type-I long terminal repeat.
FEBS letters 1998;428(3):183-7.
1998: Nirit Mor-Vaknin; H Turgeman; Amram Torgeman; Marina Wolfson; Mahmoud Huleihel; Mordechai Aboud
Rapid syncytium formation between human T-cell leukaemia virus type-I (HTLV-I)-infected T-cells and human nervous system cells: a possible implication for tropical spastic paraparesis/HTLV-I associated myelopathy.
Cell biology international 1998;22(2):95-103.
1997: Nirit Mor-Vaknin; Amram Torgeman; D Galron; Martin Löchelt; Rolf M Flügel; Mordechai Aboud
The long terminal repeats of human immunodeficiency virus type-1 and human T-cell leukemia virus type-I are activated by 12-O-tetradecanoylphorbol-13-acetate through different pathways.
Virology 1997;232(2):337-44.
1997: P Yang; M Zemba; Mordechai Aboud; Rolf M Flügel; Martin Löchelt
Deletion analysis of both the long terminal repeat and the internal promoters of the human foamy virus.
Virus genes 1997;15(1):17-23.
1995: D Kögel; Mordechai Aboud; Rolf M Flügel
Molecular biological characterization of the human foamy virus reverse transcriptase and ribonuclease H domains.
Virology 1995;213(1):97-108.
1995: Daniel Benharroch; T Yermiahu; David B Geffen; Isebrand Prinsloo; Jacob Gopas; S Segal; Mordechai Aboud
Expression of c-myc and c-ras oncogenes in the neoplastic and non-neoplastic cells of Hodgkin's disease.
European journal of haematology 1995;55(3):178-83.
1995: D Kögel; Mordechai Aboud; Rolf M Flügel
Mutational analysis of the reverse transcriptase and ribonuclease H domains of the human foamy virus.
Nucleic acids research 1995;23(14):2621-5.
1995: E Priel; E Aflalo; I Seri; Louis E. Henderson; L O Arthur; Mordechai Aboud; S Segal; Donald G Blair
DNA binding properties of the zinc-bound and zinc-free HIV nucleocapsid protein: supercoiled DNA unwinding and DNA-protein cleavable complex formation.
FEBS letters 1995;362(1):59-64.
1995: T Revazova; A Dombrovsky; M Lochelt; R M Flugel; Mordechai Aboud
Tax-independent stimulation of human T-cell leukemia virus type-I expression and differential effects on its infectivity by subtoxic and toxic doses of 3-methylcholanthrene.
Cellular & molecular biology research 1995;41(5):377-85.
1994: M Wolfson; M Lev; I Avinoah; Z Malik; Martin Löchelt; Rolf M Flügel; A Dombrovski; Mordechai Aboud
Stimulation of virus production and induction of self-syncytium formation in human T-cell leukemia virus type I- and type II-infected T cells by 12-O-tetradecanoylphorbol-13-acetate.
Journal of virology 1994;68(7):4695-9.
1994: Martin Löchelt; Rolf M Flügel; Mordechai Aboud
The human foamy virus internal promoter directs the expression of the functional Bel 1 transactivator and Bet protein early after infection.
Journal of virology 1994;68(2):638-45.
1993: Martin Löchelt; Mordechai Aboud; Rolf M Flügel
Increase in the basal transcriptional activity of the human foamy virus internal promoter by the homologous long terminal repeat promoter in cis.
Nucleic acids research 1993;21(18):4226-30.
1993: M Wolfson; I Nathan; M Aharon; Alexander Dvilansky; Mordechai Aboud
Synergistic effect of interferon-gamma and phorbol myristate acetate on superoxide production by human monocytes.
Cell biology international 1993;17(6):595-602.
1993: E Priel; E Aflalo; G Chechelnitsky; Daniel Benharroch; Mordechai Aboud; S Segal
Inhibition of retrovirus-induced disease in mice by camptothecin.
Journal of virology 1993;67(6):3624-9.
1993: G Feldman; Mordechai Aboud
Stimulation of HTLV-I expression by subtoxic dose of 3-methylcholanthrene.
Leukemia research 1993;17(5):429-35.
1992: Mordechai Aboud; M Rosner; A Dombrovsky; T Revazova; G Feldman; L Tolpolar; Y Strilitz-Hassan; R M Flügel
Interactions between retroviruses and environmental carcinogens and their role in animal and human leukemogenesis.
Leukemia research 1992;16(11):1061-9.
1992: Mordechai Aboud; S Segal; E Priel; D G Blair; B O'Hara
Effect of temperature on the expression of major histocompatibility complex class-I antigens.
Immunological investigations 1992;21(3):219-29.
1992: I Har-Vardi; Jacob Gopas; Bracha Rager-Zisman; G J Hammerling; S Segal; Mordechai Aboud
Differential expression of the H-2Dk MHC class-I antigen and tissue inhibitor of metalloproteinases in metastatic and nonmetastatic T-10 fibrosarcoma cells.
Invasion & metastasis 1992;12(5-6):301-8.
1991: Bracha Rager-Zisman; Mordechai Aboud; Jacob Gopas; I Har-Vardi; G J Hämmerling; S Segal
Resistance to NK and metastatic potential of fibrosarcoma cells is associated with products encoded by the H-2D region.
Seminars in cancer biology 1991;2(5):329-36.
1991: E Priel; Y Hassan; Mahmoud Huleihel; S Segal; Mordechai Aboud
Amplification of the Moloney murine leukaemia virus genome and its possible role in facilitation of chemical carcinogenesis in normal rat kidney cells.
The Journal of general virology 1991;72 ( Pt 9)():2317-20.
1991: Mordechai Aboud; H Amitai; Mahmoud Huleihel; I Har-vardi; Jacob Gopas; S Segal
Differential transcriptional control of the H-2K and H-2D loci of the major histocompatibility complex in fibrosarcoma cells.
Immunological investigations 1991;20(5-6):475-85.
1990: E Priel; S D Showalter; M Roberts; S Oroszlan; S Segal; Mordechai Aboud; Donald G Blair
Topoisomerase I activity associated with human immunodeficiency virus (HIV) particles and equine infectious anemia virus core.
The EMBO journal 1990;9(12):4167-72.
1990: Y Hassan; E Priel; S Segal; Mahmoud Huleihel; Mordechai Aboud
Chemical-retroviral cooperative carcinogenesis and its molecular basis in NIH/3T3 cells.
Carcinogenesis 1990;11(12):2097-102.
1990: Mordechai Aboud; M Askenazi-Rydel; I Har-Vardi; Yacob Weinstein; Jacob Gopas; S Segal
Changes in the coding sequence of the H-2Dk gene of metastatic cells that might account for immunogenic abnormality of its encoded antigen.
Biochemical and biophysical research communications 1990;171(3):1395-401.
1986: Y Hassan; Mahmoud Huleihel; E Priel; Karli Rosner; Mordechai Aboud
Effect of Moloney murine leukemia virus on the carcinogenicity of 3-methylcholanthrene in normal rat kidney cells.
Archives of virology 1986;90(1-2):63-71.
1986: Y Hassan; M Wolfson; Mordechai Aboud
Phenotypic heterogeneity in 3-methylcholanthrene-induced transformation of normal rat kidney cells infected with Moloney murine leukemia virus.
Cell biology international reports 1986;10(1):19-26.
1985: Y Hassan; Mahmoud Huleihel; E Priel; M Wolfson; Mordechai Aboud
Effect of mouse interferon on chemical carcinogenesis in normal rat kidney cells infected with Moloney murine leukemia virus.
Carcinogenesis 1985;6(12):1787-90.
1985: E Priel; Mordechai Aboud; H Feigelman; S Segal
Topoisomerase-II activity in human leukemic and lymphoblastoid cells.
Biochemical and biophysical research communications 1985;130(1):325-32.
1983: Mahmoud Huleihel; Mordechai Aboud
Inhibition of retrovirus DNA supercoiling in interferon-treated cells.
Journal of virology 1983;48(1):120-6.
1983: Mahmoud Huleihel; J Marvit; Mordechai Aboud
The mechanism of interferon effect on cell transformation by murine sarcoma virus.
International journal of cancer. Journal international du cancer 1983;31(6):737-43.
1983: Mordechai Aboud; Y Hassan
Accumulation and breakdown of RNA-deficient intracellular virus particles in interferon-treated NIH 3T3 cells chronically producing Moloney murine leukemia virus.
Journal of virology 1983;45(2):489-95.
1983: S Salzberg; R Shurtz; J Feder; Mordechai Aboud
Effect of interferon on the penetration of murine leukemia virus and the binding of its genome RNA to polyribosomes at the early stage of infection.
Archives of virology 1983;78(3-4):267-78.
1983: Mordechai Aboud; Z Malik; S Bari; R Kimchi; Y Hassan; S Salzberg
Effect of interferon on the formation and release of intracellular virions in NIH/3T3 cells chronically infected with Moloney murine leukemia virus.
Journal of interferon research 1983;3(1):33-44.
1983: Mordechai Aboud; A Dank-Nudel; R Shurtz; S Salzberg
Evidence for a cytoplasmic factor regulating murine leukemia virus DNA synthesis and its preliminary characterization.
Archives of virology 1983;75(3):191-200.
1982: Mordechai Aboud; R Shoor; S Bari; Y Hasan; R Shurtz; Z Malik; S Salzberg
Biochemical analysis and electron microscopic study on intracellular virions in NIH/3T3 mouse cells chronically infected with Moloney murine leukaemia virus: effect of interferon.
The Journal of general virology 1982;62 (Pt 2)():219-25.
1982: Mahmoud Huleihel; Mordechai Aboud
Effect of mouse interferon on retrovirus production by chronically infected rat cells.
Antiviral research 1982;2(3):167-75.
1982: Mahmoud Huleihel; Mordechai Aboud
Effect of mouse interferon on cell transformation and virus production in rat cells exogenously infected with moloney murine sarcoma and leukemia viruses.
International journal of cancer. Journal international du cancer 1982;29(4):471-6.
1982: Mordechai Aboud; M Wolfson; Y Hassan; Mahmoud Huleihel
Rapid purification of extracellular and intracellular Moloney murine leukemia virus.
Archives of virology 1982;71(3):185-95.
1982: Mordechai Aboud; Y Hassan; Mahmoud Huleihel
Effect of interferon on assembly of intracellular Moloney murine leukemia virus particles in chronically infected 3T3/NIH cells.
Archives of virology 1982;74(4):249-58.
1981: Mordechai Aboud; R Kimchi; M Bakhanashvili; S Salzberg
Intracellular production of virus particles and viral components in NIH/3T3 cells chronically infected with Moloney murine leukemia virus: effect of interferon.
Journal of virology 1981;40(3):830-8.
1981: Mordechai Aboud; D Moldovan-Levin; S Salzberg
Cytoplasmic viral DNA synthesis in exogenous infection of murine leukemia virus: effect of interferon and cycloheximide.
Journal of virology 1981;37(2):836-9.
1981: Mordechai Aboud; Mahmoud Huleihel
Rapid syncytium formation induced by Moloney murine sarcoma virus in 3T3/NIH cells and its delay by mouse interferon.
Archives of virology 1981;70(2):103-14.
1980: Mordechai Aboud; R Shoor; S Salzberg
Effect of human fibroblast interferon on uncoating and release of murine leukaemia virus in NIH/3T3 mouse cells.
The Journal of general virology 1980;51(Pt 2):431-4.
1980: Mordechai Aboud; R Shoor; S Salzberg
An effect of interferon on the uncoating of murine leukaemia virus not related to the antiviral state.
The Journal of general virology 1980;51(Pt 2):425-9.
1980: S Salzberg; M Bakhanashvili; S Bari; I Berman; Mordechai Aboud
Characterization of intracellular viral RNA in interferon-treated cells chronically infected with murine leukemia virus.
Journal of virology 1980;35(3):694-703.
1980: Mordechai Aboud; T Michalski-Stern; Yeshayahu Nitzan; S Salzberg
Enhancement of cellular protein synthesis sensitivity to diphtheria toxin by interferon.
Infection and immunity 1980;28(1):11-6.