James Douglas Engel

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Shimizu Ritsuko; Kobayashi Eri; Engel James Douglas; Yamamoto Masayuki
Induction of hyperproliferative fetal megakaryopoiesis by an N-terminally truncated GATA1 mutant.
Maeda Atsuko; Moriguchi Takashi; Hamada Michito; Kusakabe Manabu; Fujioka Yuki; Nakano Takako; Yoh Keigyou; Lim Kim-Chew; Engel James Douglas; Takahashi Satoru
Transcription factor GATA-3 is essential for lens development.
Takeuchi Takashi; Kudo Takashi; Ogata Kiyohito; Hamada Michito; Nakamura Megumi; Kito Katsumi; Abe Yasuhito; Ueda Norifumi; Yamamoto Masayuki; Engel James Douglas; Takahashi Satoru
Neither MafA/L-Maf nor MafB is essential for lens development in mice.

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All Publications

2009: Shimizu Ritsuko; Kobayashi Eri; Engel James Douglas; Yamamoto Masayuki
Induction of hyperproliferative fetal megakaryopoiesis by an N-terminally truncated GATA1 mutant.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(9):1119-31.
2009: Maeda Atsuko; Moriguchi Takashi; Hamada Michito; Kusakabe Manabu; Fujioka Yuki; Nakano Takako; Yoh Keigyou; Lim Kim-Chew; Engel James Douglas; Takahashi Satoru
Transcription factor GATA-3 is essential for lens development.
Developmental dynamics : an official publication of the American Association of Anatomists 2009;238(9):2280-91.
2009: Takeuchi Takashi; Kudo Takashi; Ogata Kiyohito; Hamada Michito; Nakamura Megumi; Kito Katsumi; Abe Yasuhito; Ueda Norifumi; Yamamoto Masayuki; Engel James Douglas; Takahashi Satoru
Neither MafA/L-Maf nor MafB is essential for lens development in mice.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(8):941-7.
2009: Nozawa Daisuke; Suzuki Norio; Kobayashi-Osaki Maki; Pan Xiaoqing; Engel James Douglas; Yamamoto Masayuki
GATA2-dependent and region-specific regulation of Gata2 transcription in the mouse midbrain.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(5):569-82.
2008: Rao Arvind; Hero Alfred O; States David J; Engel James Douglas
Using directed information to build biologically relevant influence networks.
Journal of bioinformatics and computational biology 2008;6(3):493-519.
2008: Hozumi Katsuto; Negishi Naoko; Tsuchiya Izumi; Abe Natsumi; Hirano Ken-ichi; Suzuki Daisuke; Yamamoto Masayuki; Engel James D; Habu Sonoko
Notch signaling is necessary for GATA3 function in the initiation of T cell development.
European journal of immunology 2008;38(4):977-85.
2008: Shimizu Ritsuko; Engel James Douglas; Yamamoto Masayuki
GATA1-related leukaemias.
Nature reviews. Cancer 2008;8(4):279-87.
2008: Brandt William; Khandekar Melin; Suzuki Norio; Yamamoto Masayuki; Lim Kim-Chew; Engel James Douglas
Defining the functional boundaries of the Gata2 locus by rescue with a linked bacterial artificial chromosome transgene.
The Journal of biological chemistry 2008;283(14):8976-83.
2008: Hoshino Tomofumi; Shimizu Ritsuko; Ohmori Shinya; Nagano Masumi; Pan Xiaoqing; Ohneda Osamu; Khandekar Melin; Yamamoto Masayuki; Lim Kim-Chew; Engel James Douglas
Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT.
Genes to cells : devoted to molecular & cellular mechanisms 2008;13(2):159-70.
2007: Tanabe Osamu; Shen Yannan; Liu Qinghui; Campbell Andrew D; Kuroha Takashi; Yamamoto Masayuki; Engel James Douglas
The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription.
Genes & development 2007;21(21):2832-44.
2007: Shimotsuma Motoshi; Matsuzaki Hitomi; Tanabe Osamu; Campbell Andrew D; Engel James Douglas; Fukamizu Akiyoshi; Tanimoto Keiji
Linear distance from the locus control region determines epsilon-globin transcriptional activity.
Molecular and cellular biology 2007;27(16):5664-72.
2007: Tanabe Osamu; McPhee David; Kobayashi Shoko; Shen Yannan; Brandt William; Jiang Xia; Campbell Andrew D; Chen Yei-Tsung; Chang Chawn shang; Yamamoto Masayuki; Tanimoto Keiji; Engel James Douglas
Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4.
The EMBO journal 2007;26(9):2295-306.
2007: Khandekar Melin; Brandt William; Zhou Yinghui; Dagenais Susan; Glover Thomas W; Suzuki Norio; Shimizu Ritsuko; Yamamoto Masayuki; Lim Kim-Chew; Engel James Douglas
A Gata2 intronic enhancer confers its pan-endothelia-specific regulation.
Development (Cambridge, England) 2007;134(9):1703-12.
2007: Hu Xiao; Eszterhas Susan; Pallazzi Nicolas; Bouhassira Eric E; Fields Jennifer; Tanabe Osamu; Gerber Scott A; Bulger Michael; Engel James Douglas; Groudine Mark; Fiering Steven
Transcriptional interference among the murine beta-like globin genes.
Blood 2007;109(5):2210-6.
2007: Hasegawa Susan L; Moriguchi Takashi; Rao Arvind; Kuroha Takashi; Engel James Douglas; Lim Kim-Chew
Dosage-dependent rescue of definitive nephrogenesis by a distant Gata3 enhancer.
Developmental biology 2007;301(2):568-77.
2007: Rao Arvind; Hero Iii Alfred O; States David J; Engel James Douglas
Motif discovery in tissue-specific regulatory sequences using directed information.
EURASIP journal on bioinformatics & systems biology 2007;():13853.
2007: Rao Arvind; Hero Iii Alfred O; States David J; Engel James Douglas
Inferring time-varying network topologies from gene expression data.
EURASIP journal on bioinformatics & systems biology 2007;():51947.
2007: Rao Arvind; Hero Alfred O; States David J; Engel James Douglas
Using directed information to build biologically relevant influence networks.
Computational systems bioinformatics / Life Sciences Society. Computational Systems Bioinformatics Conference 2007;6():145-56.
2007: Miles Joanne; Mitchell Jennifer A; Chakalova Lyubomira; Goyenechea Beatriz; Osborne Cameron S; O'Neill Laura; Tanimoto Keiji; Engel James Douglas; Fraser Peter
Intergenic transcription, cell-cycle and the developmentally regulated epigenetic profile of the human beta-globin locus.
PloS one 2007;2(7):e630.
2006: Moriguchi Takashi; Takako Nakano; Hamada Michito; Maeda Atsuko; Fujioka Yuki; Kuroha Takashi; Huber Reuben E; Hasegawa Susan L; Rao Arvind; Yamamoto Masayuki; Takahashi Satoru; Lim Kim-Chew; Engel James Douglas
Gata3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation.
Development (Cambridge, England) 2006;133(19):3871-81.
2006: Moriguchi Takashi; Hamada Michito; Morito Naoki; Terunuma Tsumoru; Hasegawa Kazuteru; Zhang Chuan; Yokomizo Tomomasa; Esaki Ritsuko; Kuroda Etsushi; Yoh Keigyou; Kudo Takashi; Nagata Michio; Greaves David R; Engel James Douglas; Yamamoto Masayuki; Takahashi Satoru
MafB is essential for renal development and F4/80 expression in macrophages.
Molecular and cellular biology 2006;26(15):5715-27.
2006: Fraser Peter; Engel James Douglas
Constricting restricted transcription: the (actively?) shrinking web.
Genes & development 2006;20(11):1379-83.
2006: Motohashi Hozumi; Katsuoka Fumiki; Miyoshi Chika; Uchimura Yasuhiro; Saitoh Hisato; Francastel Claire; Engel James Douglas; Yamamoto Masayuki
MafG sumoylation is required for active transcriptional repression.
Molecular and cellular biology 2006;26(12):4652-63.
2006: Yamamoto Tae; Kyo Motoki; Kamiya Terue; Tanaka Toshiyuki; Engel James Douglas; Motohashi Hozumi; Yamamoto Masayuki
Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(6):575-91.
2006: Suzuki Norio; Ohneda Osamu; Minegishi Naoko; Nishikawa Mitsuo; Ohta Takayuki; Takahashi Satoru; Engel James Douglas; Yamamoto Masayuki
Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2202-7.
2006: Goren Alon; Simchen Giora; Fibach Eitan; Szabo Piroska E; Tanimoto Keiji; Chakalova Lyubomira; Pfeifer Gerd P; Fraser Peter J; Engel James D; Cedar Howard
Fine tuning of globin gene expression by DNA methylation.
PloS one 2006;1():e46.
2005: Katsuoka Fumiki; Motohashi Hozumi; Ishii Tetsuro; Aburatani Hiroyuki; Engel James Douglas; Yamamoto Masayuki
Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes.
Molecular and cellular biology 2005;25(18):8044-51.
2005: Kobayashi-Osaki Maki; Ohneda Osamu; Suzuki Norio; Minegishi Naoko; Yokomizo Tomomasa; Takahashi Satoru; Lim Kim-Chew; Engel James Douglas; Yamamoto Masayuki
GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene.
Molecular and cellular biology 2005;25(16):7005-20.
2005: Tanimoto Keiji; Shimotsuma Motoshi; Matsuzaki Hitomi; Omori Akane; Bungert Jörg; Engel James Douglas; Fukamizu Akiyoshi
Genomic imprinting recapitulated in the human beta-globin locus.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10250-5.
2005: Zhang Chuan; Moriguchi Takashi; Kajihara Miwako; Esaki Ritsuko; Harada Ayako; Shimohata Homare; Oishi Hisashi; Hamada Michito; Morito Naoki; Hasegawa Kazuteru; Kudo Takashi; Engel James Douglas; Yamamoto Masayuki; Takahashi Satoru
MafA is a key regulator of glucose-stimulated insulin secretion.
Molecular and cellular biology 2005;25(12):4969-76.
2005: Pan Xiaoqing; Ohneda Osamu; Ohneda Kinuko; Lindeboom Fokke; Iwata Fumiko; Shimizu Ritsuko; Nagano Masumi; Suwabe Naruyoshi; Philipsen Sjaak; Lim Kim-Chew; Engel James D; Yamamoto Masayuki
Graded levels of GATA-1 expression modulate survival, proliferation, and differentiation of erythroid progenitors.
The Journal of biological chemistry 2005;280(23):22385-94.
2005: Omori Akane; Tanabe Osamu; Engel James Douglas; Fukamizu Akiyoshi; Tanimoto Keiji
Adult stage gamma-globin silencing is mediated by a promoter direct repeat element.
Molecular and cellular biology 2005;25(9):3443-51.
2005: Shimizu Taku; Oishi Takayuki; Omori Akane; Sugiura Akiko; Hirota Keiko; Aoyama Hisanori; Saito Tomoko; Sugaya Takeshi; Kon Yasuhiro; Engel James Douglas; Fukamizu Akiyoshi; Tanimoto Keiji
Identification of cis-regulatory sequences in the human angiotensinogen gene by transgene coplacement and site-specific recombination.
Molecular and cellular biology 2005;25(8):2938-45.
2005: Katsuoka Fumiki; Motohashi Hozumi; Engel James Douglas; Yamamoto Masayuki
Nrf2 transcriptionally activates the mafG gene through an antioxidant response element.
The Journal of biological chemistry 2005;280(6):4483-90.
2004: Khandekar Melin; Suzuki Norio; Lewton Jon; Yamamoto Masayuki; Engel James Douglas
Multiple, distant Gata2 enhancers specify temporally and tissue-specific patterning in the developing urogenital system.
Molecular and cellular biology 2004;24(23):10263-76.
2004: Vieira Karen F; Levings Padraic P; Hill Meredith A; Crusselle Valerie J; Kang Sung-Hae Lee; Engel James Douglas; Bungert Jörg
Recruitment of transcription complexes to the beta-globin gene locus in vivo and in vitro.
The Journal of biological chemistry 2004;279(48):50350-7.
2004: van der Wees Jacqueline; van Looij Marjolein A J; de Ruiter M Martijn; Elias Helineth; van der Burg Hans; Liem Su-San; Kurek Dorota; Engel J Doug; Karis Alar; van Zanten Bert G A; de Zeeuw Chris I; Grosveld Frank G; van Doorninck J Hikke
Hearing loss following Gata3 haploinsufficiency is caused by cochlear disorder.
Neurobiology of disease 2004;16(1):169-78.
2004: Motohashi Hozumi; Katsuoka Fumiki; Engel James Douglas; Yamamoto Masayuki
Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6379-84.
2004: Shimizu Ritsuko; Ohneda Kinuko; Engel James Douglas; Trainor Cecelia D; Yamamoto Masayuki
Transgenic rescue of GATA-1-deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia.
Blood 2004;103(7):2560-7.
2004: Craven Sarah E; Lim Kim-Chew; Ye Weilan; Engel James Douglas; de Sauvage Frederic; Rosenthal Arnon
Gata2 specifies serotonergic neurons downstream of sonic hedgehog.
Development (Cambridge, England) 2004;131(5):1165-73.
2004: Kyo Motoki; Yamamoto Tae; Motohashi Hozumi; Kamiya Terue; Kuroita Toshihiro; Tanaka Toshiyuki; Engel James Douglas; Kawakami Bunsei; Yamamoto Masayuki
Evaluation of MafG interaction with Maf recognition element arrays by surface plasmon resonance imaging technique.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(2):153-64.
2004: Dame Christof; Sola Martha C; Lim Kim-Chew; Leach Kelly M; Fandrey Joachim; Ma Yaluan; Knöpfle Gisela; Engel James Douglas; Bungert Jörg
Hepatic erythropoietin gene regulation by GATA-4.
The Journal of biological chemistry 2004;279(4):2955-61.
2003: Tanimoto Keiji; Sugiura Akiko; Omori Akane; Felsenfeld Gary; Engel James Douglas; Fukamizu Akiyoshi
Human beta-globin locus control region HS5 contains CTCF- and developmental stage-dependent enhancer-blocking activity in erythroid cells.
Molecular and cellular biology 2003;23(24):8946-52.
2003: Wakabayashi Nobunao; Itoh Ken; Wakabayashi Junko; Motohashi Hozumi; Noda Shuhei; Takahashi Satoru; Imakado Sumihisa; Kotsuji Tomoe; Otsuka Fujio; Roop Dennis R; Harada Takanori; Engel James Douglas; Yamamoto Masayuki
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.
Nature genetics 2003;35(3):238-45.
2003: Yoh Keigyou; Shibuya Kazuko; Morito Naoki; Nakano Takako; Ishizaki Kazusa; Shimohata Homare; Nose Masato; Izui Shozo; Shibuya Akira; Koyama Akio; Engel James Douglas; Yamamoto Masayuki; Takahashi Satoru
Transgenic overexpression of GATA-3 in T lymphocytes improves autoimmune glomerulonephritis in mice with a BXSB/MpJ-Yaa genetic background.
Journal of the American Society of Nephrology : JASN 2003;14(10):2494-502.
2003: Wakabayashi Junko; Yomogida Kentaro; Nakajima Osamu; Yoh Keigyou; Takahashi Satoru; Engel James Douglas; Ohneda Kinuko; Yamamoto Masayuki
GATA-1 testis activation region is essential for Sertoli cell-specific expression of GATA-1 gene in transgenic mouse.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(7):619-30.
2003: Katsuoka Fumiki; Motohashi Hozumi; Tamagawa Yuna; Kure Shigeo; Igarashi Kazuhiko; Engel James Douglas; Yamamoto Masayuki
Small Maf compound mutants display central nervous system neuronal degeneration, aberrant transcription, and Bach protein mislocalization coincident with myoclonus and abnormal startle response.
Molecular and cellular biology 2003;23(4):1163-74.
2002: Ohneda Kinuko; Shimizu Ritsuko; Nishimura Shigeko; Muraosa Yasushi; Takahashi Satoru; Engel James Douglas; Yamamoto Masayuki
A minigene containing four discrete cis elements recapitulates GATA-1 gene expression in vivo.
Genes to cells : devoted to molecular & cellular mechanisms 2002;7(12):1243-54.
2002: Motohashi Hozumi; O'Connor Tania; Katsuoka Fumiki; Engel James Douglas; Yamamoto Masayuki
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors.
Gene 2002;294(1-2):1-12.
2002: Tanabe Osamu; Katsuoka Fumiki; Campbell Andrew D; Song Weimin; Yamamoto Masayuki; Tanimoto Keiji; Engel James Douglas
An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer.
The EMBO journal 2002;21(13):3434-42.
2002: Crawford Susan E; Qi Chao; Misra Parimal; Stellmach Veronica; Rao M Sambasiva; Engel James D; Zhu Yijun; Reddy Janardan K
Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors.
The Journal of biological chemistry 2002;277(5):3585-92.
2001: Shimizu R; Takahashi S; Ohneda K; Engel J D; Yamamoto M
In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis.
The EMBO journal 2001;20(18):5250-60.
2001: Leach K M; Nightingale K; Igarashi K; Levings P P; Engel J D; Becker P B; Bungert J
Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of chromatin assembly.
Molecular and cellular biology 2001;21(8):2629-40.
2000: Motohashi H; Katsuoka F; Shavit J A; Engel J D; Yamamoto M
Positive or negative MARE-dependent transcriptional regulation is determined by the abundance of small Maf proteins.
Cell 2000;103(6):865-75.
2000: Tanimoto K; Liu Q; Grosveld F; Bungert J; Engel J D
Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.
Genes & development 2000;14(21):2778-94.
2000: Zhou Y; Yamamoto M; Engel J D
GATA2 is required for the generation of V2 interneurons.
Development (Cambridge, England) 2000;127(17):3829-38.
2000: Takahashi S; Shimizu R; Suwabe N; Kuroha T; Yoh K; Ohta J; Nishimura S; Lim K C; Engel J D; Yamamoto M
GATA factor transgenes under GATA-1 locus control rescue germline GATA-1 mutant deficiencies.
Blood 2000;96(3):910-6.
2000: Katsuoka F; Motohashi H; Onodera K; Suwabe N; Engel J D; Yamamoto M
One enhancer mediates mafK transcriptional activation in both hematopoietic and cardiac muscle cells.
The EMBO journal 2000;19(12):2980-91.
2000: Lim K C; Lakshmanan G; Crawford S E; Gu Y; Grosveld F; Engel J D
Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system.
Nature genetics 2000;25(2):209-12.
2000: Engel J D; Tanimoto K
Looping, linking, and chromatin activity: new insights into beta-globin locus regulation.
Cell 2000;100(5):499-502.
2000: Onodera K; Shavit J A; Motohashi H; Yamamoto M; Engel J D
Perinatal synthetic lethality and hematopoietic defects in compound mafG::mafK mutant mice.
The EMBO journal 2000;19(6):1335-45.
2000: Tanimoto K; Engel J D
In vivo modulation of human beta-globin gene switching.
Trends in cardiovascular medicine 2000;10(1):15-9.
1999: Pata I; Studer M; van Doorninck J H; Briscoe J; Kuuse S; Engel J D; Grosveld F; Karis A
The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4.
Development (Cambridge, England) 1999;126(23):5523-31.
1999: Yoshida C; Tokumasu F; Hohmura K I; Bungert J; Hayashi N; Nagasawa T; Engel J D; Yamamoto M; Takeyasu K; Igarashi K
Long range interaction of cis-DNA elements mediated by architectural transcription factor Bach1.
Genes to cells : devoted to molecular & cellular mechanisms 1999;4(11):643-55.
1999: Tanimoto K; Liu Q; Bungert J; Engel J D
The polyoma virus enhancer cannot substitute for DNase I core hypersensitive sites 2-4 in the human beta-globin LCR.
Nucleic acids research 1999;27(15):3130-7.
1999: Onodera K; Shavit J A; Motohashi H; Katsuoka F; Akasaka J E; Engel J D; Yamamoto M
Characterization of the murine mafF gene.
The Journal of biological chemistry 1999;274(30):21162-9.
1999: Hendriks R W; Nawijn M C; Engel J D; van Doorninck H; Grosveld F; Karis A
Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus.
European journal of immunology 1999;29(6):1912-8.
1999: van Doorninck J H; van Der Wees J; Karis A; Goedknegt E; Engel J D; Coesmans M; Rutteman M; Grosveld F; De Zeeuw C I
GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(12):RC12.
1999: Minegishi N; Ohta J; Yamagiwa H; Suzuki N; Kawauchi S; Zhou Y; Takahashi S; Hayashi N; Engel J D; Yamamoto M
The mouse GATA-2 gene is expressed in the para-aortic splanchnopleura and aorta-gonads and mesonephros region.
Blood 1999;93(12):4196-207.
1999: Bungert J; Tanimoto K; Patel S; Liu Q; Fear M; Engel J D
Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.
Molecular and cellular biology 1999;19(4):3062-72.
1999: Tanimoto K; Liu Q; Bungert J; Engel J D
Effects of altered gene order or orientation of the locus control region on human beta-globin gene expression in mice.
Nature 1999;398(6725):344-8.
1999: Lakshmanan G; Lieuw K H; Lim K C; Gu Y; Grosveld F; Engel J D; Karis A
Localization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locus.
Molecular and cellular biology 1999;19(2):1558-68.
1999: Itoh K; Wakabayashi N; Katoh Y; Ishii T; Igarashi K; Engel J D; Yamamoto M
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.
Genes & development 1999;13(1):76-86.
1998: Lakshmanan G; Lieuw K H; Grosveld F; Engel J D
Partial rescue of GATA-3 by yeast artificial chromosome transgenes.
Developmental biology 1998;204(2):451-63.
1998: Zhou Y; Lim K C; Onodera K; Takahashi S; Ohta J; Minegishi N; Tsai F Y; Orkin S H; Yamamoto M; Engel J D
Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development.
The EMBO journal 1998;17(22):6689-700.
1998: Motohashi H; Ohta J; Engel J D; Yamamoto M
A core region of the mafK gene IN promoter directs neurone-specific transcription in vivo.
Genes to cells : devoted to molecular & cellular mechanisms 1998;3(10):671-84.
1998: Liu Q; Tanimoto K; Bungert J; Engel J D
The A gamma-globin 3' element provides no unique function(s) for human beta-globin locus gene regulation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):9944-9.
1998: Li G; Lim K C; Engel J D; Bungert J
Individual LCR hypersensitive sites cooperate to generate an open chromatin domain spanning the human beta-globin locus.
Genes to cells : devoted to molecular & cellular mechanisms 1998;3(7):415-29.
1998: Shavit J A; Motohashi H; Onodera K; Akasaka J; Yamamoto M; Engel J D
Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice.
Genes & development 1998;12(14):2164-74.
1998: Harigae H; Takahashi S; Suwabe N; Ohtsu H; Gu L; Yang Z; Tsai F Y; Kitamura Y; Engel J D; Yamamoto M
Differential roles of GATA-1 and GATA-2 in growth and differentiation of mast cells.
Genes to cells : devoted to molecular & cellular mechanisms 1998;3(1):39-50.
1997: Lieuw K H; Li G l; Zhou Y; Grosveld F; Engel J D
Temporal and spatial control of murine GATA-3 transcription by promoter-proximal regulatory elements.
Developmental biology 1997;188(1):1-16.
1997: Motohashi H; Shavit J A; Igarashi K; Yamamoto M; Engel J D
The world according to Maf.
Nucleic acids research 1997;25(15):2953-59.
1997: Onodera K; Takahashi S; Nishimura S; Ohta J; Motohashi H; Yomogida K; Hayashi N; Engel J D; Yamamoto M
GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4487-92.
1997: Yamamoto M; Takahashi S; Onodera K; Muraosa Y; Engel J D
Upstream and downstream of erythroid transcription factor GATA-1.
Genes to cells : devoted to molecular & cellular mechanisms 1997;2(2):107-15.
1997: Onodera K; Yomogida K; Suwabe N; Takahashi S; Muraosa Y; Hayashi N; Ito E; Gu L; Rassoulzadegan M; Engel J D; Yamamoto M
Conserved structure, regulatory elements, and transcriptional regulation from the GATA-1 gene testis promoter.
Journal of biochemistry 1997;121(2):251-63.
1997: Ma G T; Roth M E; Groskopf J C; Tsai F Y; Orkin S H; Grosveld F; Engel J D; Linzer D I
GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo.
Development (Cambridge, England) 1997;124(4):907-14.
1997: Liu Q; Bungert J; Engel J D
Mutation of gene-proximal regulatory elements disrupts human epsilon-, gamma-, and beta-globin expression in yeast artificial chromosome transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):169-74.
1996: Briegel K; Bartunek P; Stengl G; Lim K C; Beug H; Engel J D; Zenke M
Regulation and function of transcription factor GATA-1 during red blood cell differentiation.
Development (Cambridge, England) 1996;122(12):3839-50.
1996: Motohashi H; Igarashi K; Onodera K; Takahashi S; Ohtani H; Nakafuku M; Nishizawa M; Engel J D; Yamamoto M
Mesodermal- vs. neuronal-specific expression of MafK is elicited by different promoters.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(2):223-38.
1996: Bungert J; Engel J D
The role of transcription factors in erythroid development.
Annals of medicine 1996;28(1):47-55.
1995: Bungert J; Davé U; Lim K C; Lieuw K H; Shavit J A; Liu Q; Engel J D
Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.
Genes & development 1995;9(24):3083-96.
1995: Pandolfi P P; Roth M E; Karis A; Leonard M W; Dzierzak E; Grosveld F G; Engel J D; Lindenbaum M H
Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis.
Nature genetics 1995;11(1):40-4.
1995: Ishihara H; Engel J D; Yamamoto M
Structure and regulation of the chicken GATA-3 gene.
Journal of biochemistry 1995;117(3):499-508.
1994: Ng Y K; George K M; Engel J D; Linzer D I
GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene.
Development (Cambridge, England) 1994;120(11):3257-66.
1994: Ness S A; Engel J D
Vintage reds and whites: combinatorial transcription factor utilization in hematopoietic differentiation.
Current opinion in genetics & development 1994;4(5):718-24.
1994: George K M; Leonard M W; Roth M E; Lieuw K H; Kioussis D; Grosveld F; Engel J D
Embryonic expression and cloning of the murine GATA-3 gene.
Development (Cambridge, England) 1994;120(9):2673-86.
1994: Nagai T; Harigae H; Ishihara H; Motohashi H; Minegishi N; Tsuchiya S; Hayashi N; Gu L; Andres B; Engel J D
Transcription factor GATA-2 is expressed in erythroid, early myeloid, and CD34+ human leukemia-derived cell lines.
Blood 1994;84(4):1074-84.
1994: Foley K P; Pruzina S; Winick J D; Engel J D; Grosveld F; Fraser P
The chicken beta/epsilon-globin enhancer directs autonomously regulated, high-level expression of the chicken epsilon-globin gene in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7252-6.
1994: Yomogida K; Ohtani H; Harigae H; Ito E; Nishimune Y; Engel J D; Yamamoto M
Developmental stage- and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells.
Development (Cambridge, England) 1994;120(7):1759-66.
1994: Lim K C; Ishihara H; Riddle R D; Yang Z; Andrews N; Yamamoto M; Engel J D
Structure and regulation of the chicken erythroid delta-aminolevulinate synthase gene.
Nucleic acids research 1994;22(7):1226-33.
1994: Yang Z; Engel J D
Biochemical characterization of the developmental stage- and tissue-specific erythroid transcription factor, NF-E4.
The Journal of biological chemistry 1994;269(13):10079-87.
1994: Kornhauser J M; Leonard M W; Yamamoto M; LaVail J H; Mayo K E; Engel J D
Temporal and spatial changes in GATA transcription factor expression are coincident with development of the chicken optic tectum.
Brain research. Molecular brain research 1994;23(1-2):100-10.
1994: Yang Z; Gu L; Romeo P H; Bories D; Motohashi H; Yamamoto M; Engel J D
Human GATA-3 trans-activation, DNA-binding, and nuclear localization activities are organized into distinct structural domains.
Molecular and cellular biology 1994;14(3):2201-12.
1993: Chiba T; Nagata Y; Kishi A; Sakamaki K; Miyajima A; Yamamoto M; Engel J D; Todokoro K
Induction of erythroid-specific gene expression in lymphoid cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11593-7.
1993: Winick J; Abel T; Leonard M W; Michelson A M; Chardon-Loriaux I; Holmgren R A; Maniatis T; Engel J D
A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster.
Development (Cambridge, England) 1993;119(4):1055-65.
1993: Foley K P; Leonard M W; Engel J D
Quantitation of RNA using the polymerase chain reaction.
Trends in genetics : TIG 1993;9(11):380-5.
1993: Leonard M W; Lim K C; Engel J D
Expression of the chicken GATA factor family during early erythroid development and differentiation.
Development (Cambridge, England) 1993;119(2):519-31.
1993: Engel J D
Developmental regulation of human beta-globin gene transcription: a switch of loyalties?
Trends in genetics : TIG 1993;9(9):304-9.
1993: Ko L J; Engel J D
DNA-binding specificities of the GATA transcription factor family.
Molecular and cellular biology 1993;13(7):4011-22.
1993: Briegel K; Lim K C; Plank C; Beug H; Engel J D; Zenke M
Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner.
Genes & development 1993;7(6):1097-109.
1993: Yang Z; Engel J D
Human T cell transcription factor GATA-3 stimulates HIV-1 expression.
Nucleic acids research 1993;21(12):2831-6.
1993: Ito E; Toki T; Ishihara H; Ohtani H; Gu L; Yokoyama M; Engel J D; Yamamoto M
Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis.
Nature 1993;362(6419):466-8.
1992: Weraarchakul-Boonmark N; Jeong J M; Murthy S N; Engel J D; Lorand L
Cloning and expression of chicken erythrocyte transglutaminase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9804-8.
1992: Foley K P; Engel J D
Individual stage selector element mutations lead to reciprocal changes in beta- vs. epsilon-globin gene transcription: genetic confirmation of promoter competition during globin gene switching.
Genes & development 1992;6(5):730-44.
1992: Holmgren R A; Engel J D
Developmental potential.
Genes & development 1992;6(2):161-5.
1992: Engel J D; Beug H; LaVail J H; Zenke M W; Mayo K; Leonard M W; Foley K P; Yang Z; Kornhauser J M; Ko L J
cis and trans regulation of tissue-specific transcription.
Journal of cell science. Supplement 1992;16():21-31.
1991: Ko L J; Yamamoto M; Leonard M W; George K M; Ting P; Engel J D
Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.
Molecular and cellular biology 1991;11(5):2778-84.
1991: Engel J D; George K M; Ko L J; Kornhauser J M; Leonard M W; Ting P; Yamamoto M
Transcription factor regulation of hematopoietic lineage cells.
Seminars in hematology 1991;28(2):158-69.
1990: Yamamoto M; Ko L J; Leonard M W; Beug H; Orkin S H; Engel J D
Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.
Genes & development 1990;4(10):1650-62.
1989: Gallarda J L; Foley K P; Yang Z Y; Engel J D
The beta-globin stage selector element factor is erythroid-specific promoter/enhancer binding protein NF-E4.
Genes & development 1989;3(12A):1845-59.
1989: Kim H R; Kennedy B S; Engel J D
Two chicken erythrocyte band 3 mRNAs are generated by alternative transcriptional initiation and differential RNA splicing.
Molecular and cellular biology 1989;9(11):5198-206.
1989: Trainor C D; Engel J D
Transcription of the chicken histone H5 gene is mediated by distinct tissue-specific elements within the promoter and the 3' enhancer.
Molecular and cellular biology 1989;9(5):2228-32.
1989: Riddle R D; Yamamoto M; Engel J D
Expression of delta-aminolevulinate synthase in avian cells: separate genes encode erythroid-specific and nonspecific isozymes.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):792-6.
1989: Engel J D; Choi O R; Endean D J; Foley K P; Gallarda J L; Yang Z Y
Genetics and biochemistry of the embryonic to adult switch in the chicken epsilon- and beta-globin genes.
Progress in clinical and biological research 1989;316A():89-103.
1988: Yamamoto M; Kure S; Engel J D; Hiraga K
Structure, turnover, and heme-mediated suppression of the level of mRNA encoding rat liver delta-aminolevulinate synthase.
The Journal of biological chemistry 1988;263(31):15973-9.
1988: Kim H R; Yew N S; Ansorge W; Voss H; Schwager C; Vennström B; Zenke M; Engel J D
Two different mRNAs are transcribed from a single genomic locus encoding the chicken erythrocyte anion transport proteins (band 3).
Molecular and cellular biology 1988;8(10):4416-24.
1988: Choi O R; Engel J D
Developmental regulation of beta-globin gene switching.
Cell 1988;55(1):17-26.
1988: Knight J; Zenke M; Disela C; Kowenz E; Vogt P; Engel J D; Hayman M J; Beug H
Temperature-sensitive v-sea transformed erythroblasts: a model system to study gene expression during erythroid differentiation.
Genes & development 1988;2(2):247-58.
1988: Zenke M; Kahn P; Disela C; Vennström B; Leutz A; Keegan K; Hayman M J; Choi H R; Yew N; Engel J D
v-erbA specifically suppresses transcription of the avian erythrocyte anion transporter (band 3) gene.
Cell 1988;52(1):107-19.
1987: Yew N S; Choi H R; Gallarda J L; Engel J D
Expression of cytoskeletal protein 4.1 during avian erythroid cellular maturation.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(4):1035-9.
1987: Engel J D; Choi O R
Beta-globin gene regulation in chicken erythroleukemia cells.
Progress in clinical and biological research 1987;251():145-59.
1987: Jendrisak J; Young R A; Engel J D
Cloning cDNA into lambda gt10 and lambda gt11.
Methods in enzymology 1987;152():359-71.
1985: Yamamoto M; Yew N S; Federspiel M; Dodgson J B; Hayashi N; Engel J D
Isolation of recombinant cDNAs encoding chicken erythroid delta-aminolevulinate synthase.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(11):3702-6.
1985: Brush D; Dodgson J B; Choi O R; Stevens P W; Engel J D
Replacement variant histone genes contain intervening sequences.
Molecular and cellular biology 1985;5(6):1307-17.
1984: Fischer H D; Dodgson J B; Hughes S; Engel J D
An unusual 5' splice sequence is efficiently utilized in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(9):2733-7.
1983: Dodgson J B; Stadt S J; Choi O R; Dolan M; Fischer H D; Engel J D
The nucleotide sequence of the embryonic chicken beta-type globin genes.
The Journal of biological chemistry 1983;258(20):12685-92.
1983: Sugarman B J; Dodgson J B; Engel J D
Genomic organization, DNA sequence, and expression of chicken embryonic histone genes.
The Journal of biological chemistry 1983;258(14):9005-16.
1983: Dodgson J B; Engel J D
The nucleotide sequence of the adult chicken alpha-globin genes.
The Journal of biological chemistry 1983;258(7):4623-9.
1983: Dolan M; Dodgson J B; Engel J D
Analysis of the adult chicken beta-globin gene. Nucleotide sequence of the locus, microheterogeneity at the 5'-end of beta-globin mRNA, and aberrant nuclear RNA species.
The Journal of biological chemistry 1983;258(6):3983-90.
1983: Engel J D; Rusling D J; McCune K C; Dodgson J B
Unusual structure of the chicken embryonic alpha-globin gene, pi'.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(5):1392-6.
1982: Grandy D K; Engel J D; Dodgson J B
Complete nucleotide sequence of a chicken H2b histone gene.
The Journal of biological chemistry 1982;257(15):8577-80.
1982: Engel J D; Sugarman B J; Dodgson J B
A chicken histone H3 gene contains intervening sequences.
Nature 1982;297(5865):434-6.
1981: McGhee J D; Wood W I; Dolan M; Engel J D; Felsenfeld G
A 200 base pair region at the 5' end of the chicken adult beta-globin gene is accessible to nuclease digestion.
Cell 1981;27(1 Pt 2):45-55.
1981: Dodgson J B; McCune K C; Rusling D J; Krust A; Engel J D
Adult chicken alpha-globin genes alpha A and alpha D: no anemic shock alpha-globin exists in domestic chickens.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(10):5998-6002.
1981: Dolan M; Sugarman B J; Dodgson J B; Engel J D
Chromosomal arrangement of the chicken beta-type globin genes.
Cell 1981;24(3):669-77.
1981: Engel J D; Dodgson J B
Histone genes are clustered but not tandemly repeated in the chicken genome.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(5):2856-60.
1980: Stalder J; Larsen A; Engel J D; Dolan M; Groudine M; Weintraub H
Tissue-specific DNA cleavages in the globin chromatin domain introduced by DNAase I.
Cell 1980;20(2):451-60.
1980: Engel J D; Dodgson J B
Analysis of the closely linked adult chicken alpha-globin genes in recombinant DNAs.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(5):2596-600.
1980: Stalder J; Groudine M; Dodgson J B; Engel J D; Weintraub H
Hb switching in chickens.
Cell 1980;19(4):973-80.
1979: Dodgson J B; Strommer J; Engel J D
Isolation of the chicken beta-globin gene and a linked embryonic beta-like globin gene from a chicken DNA recombinant library.
Cell 1979;17(4):879-87.
1979: Hughes S H; Stubblefield E; Payvar F; Engel J D; Dodgson J B; Spector D; Cordell B; Schimke R T; Varmus H E
Gene localization by chromosome fractionation: globin genes are on at least two chromosomes and three estrogen-inducible genes are on three chromosomes.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(3):1348-52.
1978: Engel J D; Dodgson J B
Analysis of the adult and embryonic chicken globin genes in chromosomal DNA.
The Journal of biological chemistry 1978;253(22):8239-46.
1978: Engel J D; Davidson N
Addition of poly(adenylic acid) to RNA using polynucleotide phosphorylase: an improved method for electron microscopic visualization of RNA-DNA hybrids.
Biochemistry 1978;17(18):3883-8.
1978: Engel J D; von Hippel P H
Effects of methylation on the stability of nucleic acid conformations. Studies at the polymer level.
The Journal of biological chemistry 1978;253(3):927-34.
1978: Engel J D; von Hippel P H
D(M6ATP) as a probe of the fidelity of base incorporation into polynucleotides by Escherichia coli DNA polymerase I.
The Journal of biological chemistry 1978;253(3):935-9.
1975: Engel J D
Mechanism of the Dimroth rearrangement in adenosine.
Biochemical and biophysical research communications 1975;64(2):581-6.
1975: McGhee J D; Engel J D
Subunit structure of chromatin is the same in plants and animals.
Nature 1975;254(5499):449-50.
1974: Engel J D; von Hippel P H
Effects of methylation on the stability of nucleic acid conformations: studies at the monomer level.
Biochemistry 1974;13(20):4143-58.
1971: Vold B; Engel J D
Use of urea in the chromatography of transfer RNA on reversed-phase column RPC-2.
Analytical biochemistry 1971;44(1):305-11.

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