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John Engelhardt

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Ziying Yan; N W Keiser; D C M Lei-Butters; John F Engelhardt
Distinct transduction difference between adeno-associated virus type 1 and type 6 vectors in human polarized airway epithelia.
Paul M Kaminsky; Nicholas W Keiser; Diana C M Lei-Butters; Ziying Yan; John F Engelhardt
Directing integrin-linked endocytosis of recombinant AAV enhances productive FAK-dependent transduction.
Yoko Nakano; Richard J H Smith; Xingshen Sun; Gregory Bonde; Robert A Cornell; John F Engelhardt; Bernd Fritzsch; Michael S Hildebrand; Israt Jahan; Botond Bánfi
A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.

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2013: Ziying Yan; N W Keiser; D C M Lei-Butters; John F Engelhardt
Distinct transduction difference between adeno-associated virus type 1 and type 6 vectors in human polarized airway epithelia.
Gene therapy 2013;20(3):328-37.
2012: Paul M Kaminsky; Nicholas W Keiser; Diana C M Lei-Butters; Ziying Yan; John F Engelhardt
Directing integrin-linked endocytosis of recombinant AAV enhances productive FAK-dependent transduction.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(5):972-83.
2012: Yoko Nakano; Richard J H Smith; Xingshen Sun; Gregory Bonde; Robert A Cornell; John F Engelhardt; Bernd Fritzsch; Michael S Hildebrand; Israt Jahan; Botond Bánfi
A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.
PLoS genetics 2012;8(10):e1002966.
2012: Dawne N Shelton; Weiliang Xie; David Bender; Koen DeGeest; John F Engelhardt; Hubert Fornalik; Xiaoming Liu; David K Meyerholz; Traci Neff; Soo Yeun Park; Michael J Goodheart
The role of LEF1 in endometrial gland formation and carcinogenesis.
PloS one 2012;7(7):e40312.
2011: Qiang Li; Nicholas J Pantazis; Netanya Y Spencer; John F Engelhardt
Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity.
The Journal of biological chemistry 2011;286(46):40151-62.
2011: Nicholas W Keiser; John F Engelhardt
New animal models of cystic fibrosis: what are they teaching us?
Current opinion in pulmonary medicine 2011;17(6):478-83.
2011: Nicholas W Keiser; Diana C M Lei-Butters; Ziying Yan; Yulong Zhang; John F Engelhardt
Unique characteristics of AAV1, 2, and 5 viral entry, intracellular trafficking, and nuclear import define transduction efficiency in HeLa cells.
Human gene therapy 2011;22(11):1433-44.
2011: Netanya Y Spencer; Ziying Yan; Ryan L Boudreau; Yulong Zhang; Meihui Luo; Qiang Li; Xin Tian; Ajay M Shah; Robin L Davisson; Beverly Davidson; Botond Banfi; John F Engelhardt
Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4.
The Journal of biological chemistry 2011;286(11):8977-87.
2011: John T Fisher; Yulong Zhang; John F Engelhardt
Comparative biology of cystic fibrosis animal models.
Methods in molecular biology (Clifton, N.J.) 2011;742():311-34.
2010: Xiaoming Liu; Meihui Luo; Weiliang Xie; James M Wells; Michael J Goodheart; John F Engelhardt
Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter.
American journal of physiology. Lung cellular and molecular physiology 2010;299(5):L694-710.
2010: Thomas H Sisson; Michael Mendez; Karen Choi; Natalya Subbotina; Anthony J Courey; Andrew Cunningham; Aditi Dave; John F Engelhardt; Xiaoming Liu; Eric White; Victor J Thannickal; Bethany B Moore; Paul J Christensen; Richard H Simon
Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis.
American journal of respiratory and critical care medicine 2010;181(3):254-63.
2009: Qiang Li; Netanya Y Spencer; Fredrick D Oakley; Garry R Buettner; John F Engelhardt
Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha.
Antioxidants & redox signaling 2009;11(6):1249-63.
2009: Fredrick D Oakley; Duane Abbott; Qiang Li; John F Engelhardt
Signaling components of redox active endosomes: the redoxosomes.
Antioxidants & redox signaling 2009;11(6):1313-33.
2009: Ziying Yan; Xingshen Sun; John F Engelhardt
Progress and prospects: techniques for site-directed mutagenesis in animal models.
Gene therapy 2009;16(5):581-8.
2009: Xiaoming Liu; Meihui Luo; Chenhong Guo; Ziying Yan; Yujiong Wang; Diana C M Lei-Butters; John F Engelhardt
Analysis of adeno-associated virus progenitor cell transduction in mouse lung.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(2):285-93.
2009: Ziying Yan; Diana Lei-Butters; John F Engelhardt; Gregory H Leno
Indexing TNF-alpha gene expression using a gene-targeted reporter cell line.
BMC biology 2009;7():8.
2008: Xingshen Sun; Ziyi Li; Yaling Yi; Juan Chen; Gregory H Leno; John F Engelhardt
Efficient term development of vitrified ferret embryos using a novel pipette chamber technique.
Biology of reproduction 2008;79(5):832-40.
2008: Xiaoming Liu; John F Engelhardt
The glandular stem/progenitor cell niche in airway development and repair.
Proceedings of the American Thoracic Society 2008;5(6):682-8.
2008: Davis R Mumbengegwi; Qiang Li; Canhui Li; Christine E Bear; John F Engelhardt
Evidence for a superoxide permeability pathway in endosomal membranes.
Molecular and cellular biology 2008;28(11):3700-12.
2008: Qiang Li; Yulong Zhang; Jennifer J Marden; Botond Banfi; John F Engelhardt
Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury.
The Biochemical journal 2008;411(3):531-41.
2008: Xingshen Sun; Ziying Yan; Yaling Yi; Ziyi Li; Diana Lei; Christopher S Rogers; Juan Chen; Yulong Zhang; Michael J Welsh; Gregory H Leno; John F Engelhardt
Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets.
The Journal of clinical investigation 2008;118(4):1578-83.
2008: Christopher S Rogers; Yanhong Hao; Tatiana Rokhlina; Melissa Samuel; David A Stoltz; Yuhong Li; Elena Petroff; Daniel W Vermeer; Amanda C Kabel; Ziying Yan; Lee Spate; David Wax; Clifton N Murphy; August Rieke; Kristin Whitworth; Michael L Linville; Scott W Korte; John F Engelhardt; Michael J Welsh; Randall S Prather
Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer.
The Journal of clinical investigation 2008;118(4):1571-7.
2008: Jennifer J Marden; Yulong Zhang; Fredrick D Oakley; Weihong Zhou; Meihui Luo; Hong Peng Jia; Paul B McCray; moshe yaniv; Jonathan B Weitzman; John F Engelhardt
JunD protects the liver from ischemia/reperfusion injury by dampening AP-1 transcriptional activation.
The Journal of biological chemistry 2008;283(11):6687-95.
2008: Maged Harraz; Jennifer J Marden; Weihong Zhou; Yulong Zhang; Aislinn Williams; Victor S Sharov; Kathryn Nelson; Meihui Luo; Henry L Paulson; Christian Schöneich; John F Engelhardt
SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model.
The Journal of clinical investigation 2008;118(2):659-70.
2007: Xiaoming Liu; Meihui Luo; Cyndi Trygg; Ziying Yan; Diana C M Lei-Butters; Carolina I Smith; Anne C Fischer; Keith Munson; William B Guggino; Bruce A Bunnell; John F Engelhardt
Biological Differences in rAAV Transduction of Airway Epithelia in Humans and in Old World Non-human Primates.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(12):2114-23.
2007: Maged Harraz; Andrea Park; Duane Abbott; Weihong Zhou; Yulong Zhang; John F Engelhardt
MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity.
Antioxidants & redox signaling 2007;9(11):1803-13.
2007: X Liu; M Luo; C Guo; Ziying Yan; Y Wang; John F Engelhardt
Comparative biology of rAAV transduction in ferret, pig and human airway epithelia.
Gene therapy 2007;14(21):1543-8.
2007: Jennifer J Marden; Maged Harraz; Aislinn J Williams; Kathryn Nelson; Meihui Luo; Henry L Paulson; John F Engelhardt
Redox modifier genes in amyotrophic lateral sclerosis in mice.
The Journal of clinical investigation 2007;117(10):2913-9.
2007: Ryan R Driskell; Michael Goodheart; Traci Neff; Xiaoming Liu; Meihui Luo; Chris Moothart; Curt D Sigmund; Ryoichi Hosokawa; Yang Chai; John F Engelhardt
Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis.
Developmental biology 2007;305(1):90-102.
2007: Xiaoming Liu; Meihui Luo; Liang Zhang; Wei Ding; Ziying Yan; John F Engelhardt
Bioelectric properties of chloride channels in human, pig, ferret, and mouse airway epithelia.
American journal of respiratory cell and molecular biology 2007;36(3):313-23.
2007: Lyle E Fox; David Green; Ziying Yan; John F Engelhardt; Chun-Fang Wu
Screen for dominant behavioral mutations caused by genomic insertion of P-element transposons in Drosophila: an examination of the integration of viral vector sequences.
Journal of neurogenetics 2007;21(1-2):31-43.
2007: Ziying Yan; Diana C M Lei-Butters; Yulong Zhang; Roman Zak; John F Engelhardt
Hybrid adeno-associated virus bearing nonhomologous inverted terminal repeats enhances dual-vector reconstruction of minigenes in vivo.
Human gene therapy 2007;18(1):81-7.
2007: Rana Dajani; Salih Sanlioglu; Yulong Zhang; Qiang Li; Martha M Monick; Eric Lazartigues; Timothy Eggleston; Robin L Davisson; Gary W Hunninghake; John F Engelhardt
Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(1):G242-52.
2006: Ziying Yan; Diana C M Lei-Butters; Xiaoming Liu; Yulong Zhang; Liang Zhang; Meihui Luo; Roman Zak; John F Engelhardt
Unique biologic properties of recombinant AAV1 transduction in polarized human airway epithelia.
The Journal of biological chemistry 2006;281(40):29684-92.
2006: Shawn D Hingtgen; Xin Tian; Jusan Yang; Shannon M Dunlay; Andrew Peek; Yihe Wu; Ram V Sharma; John F Engelhardt; Robin L Davisson
Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy.
Physiological genomics 2006;26(3):180-91.
2006: John F Engelhardt
AAV hits the genomic bull's-eye.
Nature biotechnology 2006;24(8):949-50.
2006: Ziyi Li; Xingshen Sun; Juan Chen; Gregory H Leno; John F Engelhardt
Factors affecting the efficiency of embryo transfer in the domestic ferret (Mustela putorius furo).
Theriogenology 2006;66(2):183-90.
2006: Ziyi Li; Xingshen Sun; Juan Chen; Xiaoming Liu; Samantha M Wisely; Qi Zhou; Jean-Paul Renard; Gregory H Leno; John F Engelhardt
Cloned ferrets produced by somatic cell nuclear transfer.
Developmental biology 2006;293(2):439-48.
2006: Wei Ding; Liang N Zhang; Charles Yeaman; John F Engelhardt
rAAV2 traffics through both the late and the recycling endosomes in a dose-dependent fashion.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(4):671-82.
2006: Qiang Li; John F Engelhardt
Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.
The Journal of biological chemistry 2006;281(3):1495-505.
2006: Xiaoming Liu; Ryan R Driskell; John F Engelhardt
Stem cells in the lung.
Methods in enzymology 2006;419():285-321.
2006: Qiang Li; Maged Harraz; Weihong Zhou; Liang N Zhang; Wei Ding; Yulong Zhang; Tim Eggleston; Charles Yeaman; Botond Banfi; John F Engelhardt
Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes.
Molecular and cellular biology 2006;26(1):140-54.
2006: Xiaoming Liu; Ziying Yan; Meihui Luo; John F Engelhardt
Species-specific differences in mouse and human airway epithelial biology of recombinant adeno-associated virus transduction.
American journal of respiratory cell and molecular biology 2006;34(1):56-64.
2005: Ziyi Li; Xin Chen; Xingshen Sun; Qi Zhou; Juan Chen; Gregory H Leno; John F Engelhardt
Nuclear transfer of M-phase ferret fibroblasts synchronized with the microtubule inhibitor demecolcine.
Journal of experimental zoology. Part A, Comparative experimental biology 2005;303(12):1126-34.
2005: Xiaoming Liu; Meihui Luo; Liang N Zhang; Ziying Yan; Roman Zak; Wei Ding; S Gary Mansfield; Lloyd G Mitchell; John F Engelhardt
Spliceosome-mediated RNA trans-splicing with recombinant adeno-associated virus partially restores cystic fibrosis transmembrane conductance regulator function to polarized human cystic fibrosis airway epithelial cells.
Human gene therapy 2005;16(9):1116-23.
2005: Ziyi Li; Xingshen Sun; Juan Chen; Gregory H Leno; John F Engelhardt
Factors affecting the electrofusion of mouse and ferret oocytes with ferret somatic cells.
Molecular reproduction and development 2005;72(1):40-7.
2005: Wei Ding; Liang Zhang; Ziying Yan; John F Engelhardt
Intracellular trafficking of adeno-associated viral vectors.
Gene therapy 2005;12(11):873-80.
2005: Rana Dajani; Yulong Zhang; Peter J Taft; Sue M Travis; Timothy D Starner; Ansgar Olsen; Joseph Zabner; Michael J Welsh; John F Engelhardt
Lysozyme secretion by submucosal glands protects the airway from bacterial infection.
American journal of respiratory cell and molecular biology 2005;32(6):548-52.
2005: Ziying Yan; Roman Zak; Yulong Zhang; John F Engelhardt
Inverted terminal repeat sequences are important for intermolecular recombination and circularization of adeno-associated virus genomes.
Journal of virology 2005;79(1):364-79.
2004: Liang N Zhang; Philip H Karp; Christopher J Gerard; Eric Pastor; Douglas Laux; Keith Munson; Ziying Yan; Xiaoming Liu; Simon Godwin; Christie P Thomas; Joseph Zabner; Huidong Shi; Charles Caldwell; Richard Peluso; Barrie Carter; John F Engelhardt
Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(6):990-1002.
2004: Ryan R Driskell; Xiaoming Liu; Meihui Luo; Mohammed Filali; Weihong Zhou; Duane Abbott; Ningli Cheng; Chris Moothart; Curt D Sigmund; John F Engelhardt
Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis.
American journal of physiology. Lung cellular and molecular physiology 2004;287(4):L752-63.
2004: Matthew C Zimmerman; Ryan P Dunlay; Eric Lazartigues; Yulong Zhang; Ram V Sharma; John F Engelhardt; Robin L Davisson
Requirement for Rac1-dependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin II in the brain.
Circulation research 2004;95(5):532-9.
2004: Xiaoming Liu; Ryan R Driskell; Meihui Luo; Duane Abbott; Mohammed Filali; Ningli Cheng; Curt D Sigmund; John F Engelhardt
Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin.
The Journal of investigative dermatology 2004;123(2):264-74.
2004: Xiaoming Liu; Ziying Yan; Meihui Luo; Roman Zak; Ziyi Li; Ryan R Driskell; Yumao Huang; Nam Tran; John F Engelhardt
Targeted correction of single-base-pair mutations with adeno-associated virus vectors under nonselective conditions.
Journal of virology 2004;78(8):4165-75.
2004: Chenguang Fan; Qiang Li; Yulong Zhang; Xiaoming Liu; Meihui Luo; Duane Abbott; Weihong Zhou; John F Engelhardt
IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation.
The Journal of clinical investigation 2004;113(5):746-55.
2004: Ziying Yan; Roman Zak; Yulong Zhang; Wei Ding; Simon Godwin; Keith Munson; Richard Peluso; John F Engelhardt
Distinct classes of proteasome-modulating agents cooperatively augment recombinant adeno-associated virus type 2 and type 5-mediated transduction from the apical surfaces of human airway epithelia.
Journal of virology 2004;78(6):2863-74.
2004: Xiaoming Liu; Ryan R Driskell; John F Engelhardt
Airway glandular development and stem cells.
Current topics in developmental biology 2004;64():33-56.
2003: Ziyi Li; John F Engelhardt
Progress toward generating a ferret model of cystic fibrosis by somatic cell nuclear transfer.
Reproductive biology and endocrinology : RB&E 2003;1():83.
2003: Wei Ding; Ziying Yan; Roman Zak; Milene T Saavedra; David M Rodman; John F Engelhardt
Second-strand genome conversion of adeno-associated virus type 2 (AAV-2) and AAV-5 is not rate limiting following apical infection of polarized human airway epithelia.
Journal of virology 2003;77(13):7361-6.
2003: Ziyi Li; Maryam Rezaei Sabet; Qi Zhou; Xiaoming Liu; Wei Ding; Yulong Zhang; Jean-Paul Renard; John F Engelhardt
Developmental capacity of ferret embryos by nuclear transfer using G0/G1-phase fetal fibroblasts.
Biology of reproduction 2003;68(6):2297-303.
2003: Jusan Yang; Jennifer J Marden; Chenguang Fan; Salih Sanlioglu; Robert M Weiss; Teresa C Ritchie; Robin L Davisson; John F Engelhardt
Genetic redox preconditioning differentially modulates AP-1 and NF kappa B responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(3):341-53.
2003: Nam D Tran; Xiaoming Liu; Ziying Yan; Duane Abbote; Qinshi Jiang; Eric B Kmiec; Curt D Sigmund; John F Engelhardt
Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(2):248-53.
2003: Chenguang Fan; Qiang Li; Dan Ross; John F Engelhardt
Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation.
The Journal of biological chemistry 2003;278(3):2072-80.
2003: Ryan A Driskell; John F Engelhardt
Current status of gene therapy for inherited lung diseases.
Annual review of physiology 2003;65():585-612.
2002: Chenguang Fan; Jusan Yang; John F Engelhardt
Temporal pattern of NFkappaB activation influences apoptotic cell fate in a stimuli-dependent fashion.
Journal of cell science 2002;115(Pt 24):4843-53.
2002: Kevin C Doerschug; Salih Sanlioglu; Dawn M Flaherty; Rebecca L Wilson; Timur O Yarovinsky; Martha M Monick; John F Engelhardt; Gary W Hunninghake
First-generation adenovirus vectors shorten survival time in a murine model of sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6539-45.
2002: Mohammed Filali; Ningli Cheng; Duane Abbott; Vladimir Leontiev; John F Engelhardt
Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter.
The Journal of biological chemistry 2002;277(36):33398-410.
2002: John F Engelhardt
The lung as a metabolic factory for gene therapy.
The Journal of clinical investigation 2002;110(4):429-32.
2002: Grace S Yang; Michael Schmidt; Ziying Yan; Jonathan D Lindbloom; Thomas C Harding; Brian A Donahue; John F Engelhardt; robert kotin; Beverly L Davidson
Virus-mediated transduction of murine retina with adeno-associated virus: effects of viral capsid and genome size.
Journal of virology 2002;76(15):7651-60.
2002: Ziyi Li; Qinshi Jiang; Maryam Rezaei Sabet; Yulong Zhang; Teresa C Ritchie; John F Engelhardt
Conditions for in vitro maturation and artificial activation of ferret oocytes.
Biology of reproduction 2002;66(5):1380-6.
2002: Ji-Qin Yang; Garry R Buettner; Frederick E Domann; Qiang Li; John F Engelhardt; Christine Weydert; Larry W Oberley
v-Ha-ras mitogenic signaling through superoxide and derived reactive oxygen species.
Molecular carcinogenesis 2002;33(4):206-18.
2002: Ziying Yan; Roman Zak; G W Gant Luxton; Teresa C Ritchie; Ursula Bantel-Schaal; John F Engelhardt
Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors.
Journal of virology 2002;76(5):2043-53.
2002: Mohammed Filali; Xiaoming Liu; Ningli Cheng; Duane Abbott; Vladimir Leontiev; John F Engelhardt
Mechanisms of submucosal gland morphogenesis in the airway.
Novartis Foundation symposium 2002;248():38-45; discussion 45-50, 277-82.
2002: Jusan Yang; Teresa C Ritchie; John F Engelhardt
Model system for developing gene therapy approaches for myocardial ischemia-reperfusion injury.
Methods in enzymology 2002;353():321-36.
2002: Mohammed Filali; Yulong Zhang; Teresa C Ritchie; John F Engelhardt
Xenograft model of the CF airway.
Methods in molecular medicine 2002;70():537-50.
2002: Ziying Yan; Teresa C Ritchie; Dongsheng Duan; John F Engelhardt
Recombinant AAV-mediated gene delivery using dual vector heterodimerization.
Methods in enzymology 2002;346():334-57.
2002: Xiaoming Liu; Qinshi Jiang; S Gary Mansfield; M Puttaraju; Yulong Zhang; Weihong Zhou; Jonathan A Cohn; Mariano A Garcia-Blanco; Lloyd G Mitchell; John F Engelhardt
Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing.
Nature biotechnology 2002;20(1):47-52.
2001: Z Y Li; Q S Jiang; Y L Zhang; X M Liu; John F Engelhardt
Successful production of offspring after superovulation and in vitro culture of embryos from domestic ferrets (Mustela putorius furos).
Reproduction (Cambridge, England) 2001;122(4):611-8.
2001: Dongsheng Duan; Y Yue; John F Engelhardt
Expanding AAV packaging capacity with trans-splicing or overlapping vectors: a quantitative comparison.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(4):383-91.
2001: Salih Sanlioglu; C M Williams; Lobelia Samavati; Noah S Butler; Gufeng Wang; Paul B McCray; Teresa C Ritchie; Gary W Hunninghake; E Zandi; John F Engelhardt
Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B.
The Journal of biological chemistry 2001;276(32):30188-98.
2001: Dongsheng Duan; Ziying Yan; Y Yue; Wei Ding; John F Engelhardt
Enhancement of muscle gene delivery with pseudotyped adeno-associated virus type 5 correlates with myoblast differentiation.
Journal of virology 2001;75(16):7662-71.
2001: Salih Sanlioglu; Martha M Monick; Guven Luleci; Gary W Hunninghake; John F Engelhardt
Rate limiting steps of AAV transduction and implications for human gene therapy.
Current gene therapy 2001;1(2):137-47.
2001: Qiang Li; Salih Sanlioglu; S Li; Teresa C Ritchie; Larry W Oberley; John F Engelhardt
GPx-1 gene delivery modulates NFkappaB activation following diverse environmental injuries through a specific subunit of the IKK complex.
Antioxidants & redox signaling 2001;3(3):415-32.
2001: John F Engelhardt
Stem cell niches in the mouse airway.
American journal of respiratory cell and molecular biology 2001;24(6):649-52.
2001: D Duan; Y Zhang; John F Engelhardt
Gene delivery to the airway.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2001;Chapter 13():Unit 13.9.
2001: Weihong Zhou; Yulong Zhang; M S Hosch; A Lang; Ralf Michael Zwacka; John F Engelhardt
Subcellular site of superoxide dismutase expression differentially controls AP-1 activity and injury in mouse liver following ischemia/reperfusion.
Hepatology (Baltimore, Md.) 2001;33(4):902-14.
2001: Teresa C Ritchie; Weihong Zhou; E McKinstry; M Hosch; Yulong Zhang; I Nathke; John F Engelhardt
Developmental expression of catenins and associated proteins during submucosal gland morphogenesis in the airway.
Experimental lung research 2001;27(2):121-41.
2001: X Wang; Yulong Zhang; A Amberson; John F Engelhardt
New models of the tracheal airway define the glandular contribution to airway surface fluid and electrolyte composition.
American journal of respiratory cell and molecular biology 2001;24(2):195-202.
2000: Salih Sanlioglu; P K Benson; Jusan Yang; E M Atkinson; T Reynolds; John F Engelhardt
Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and phosphatidylinositol-3 kinase activation.
Journal of virology 2000;74(19):9184-96.
2000: Ziying Yan; Yulong Zhang; Dongsheng Duan; John F Engelhardt
Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6716-21.
2000: Dongsheng Duan; Y Yue; Ziying Yan; Jusan Yang; John F Engelhardt
Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus.
The Journal of clinical investigation 2000;105(11):1573-87.
2000: Dongsheng Duan; Y Yue; Ziying Yan; John F Engelhardt
A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation.
Nature medicine 2000;6(5):595-8.
2000: Salih Sanlioglu; P Benson; John F Engelhardt
Loss of ATM function enhances recombinant adeno-associated virus transduction and integration through pathways similar to UV irradiation.
Virology 2000;268(1):68-78.
2000: Robert Walters; Dongsheng Duan; John F Engelhardt; Michael J Welsh
Incorporation of adeno-associated virus in a calcium phosphate coprecipitate improves gene transfer to airway epithelia in vitro and in vivo.
Journal of virology 2000;74(1):535-40.
1999: Dongsheng Duan; Q Li; AW Kao; Y Yue; Jeffrey Pessin; John F Engelhardt
Dynamin is required for recombinant adeno-associated virus type 2 infection.
Journal of virology 1999;73(12):10371-6.
1999: Jusan Yang; Weihong Zhou; Yulong Zhang; Terese M Zidon; Teresa C Ritchie; John F Engelhardt
Concatamerization of adeno-associated virus circular genomes occurs through intermolecular recombination.
Journal of virology 1999;73(11):9468-77.
1999: Dongsheng Duan; Y Yue; Weihong Zhou; B Labed; Teresa C Ritchie; R Grosschedl; John F Engelhardt
Submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (LEF1).
Development (Cambridge, England) 1999;126(20):4441-53.
1999: M R Brown; Francis J Miller; W G Li; Andrew N Ellingson; J D Mozena; P Chatterjee; John F Engelhardt; Ralf Michael Zwacka; L W Oberley; Xiang Fang; Arthur A Spector; Neal L Weintraub
Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells.
Circulation research 1999;85(6):524-33.
1999: Dongsheng Duan; Ziying Yan; Y Yue; John F Engelhardt
Structural analysis of adeno-associated virus transduction circular intermediates.
Virology 1999;261(1):8-14.
1999: Salih Sanlioglu; John F Engelhardt
Cellular redox state alters recombinant adeno-associated virus transduction through tyrosine phosphatase pathways.
Gene therapy 1999;6(8):1427-37.
1999: Salih Sanlioglu; Dongsheng Duan; John F Engelhardt
Two independent molecular pathways for recombinant adeno-associated virus genome conversion occur after UV-C and E4orf6 augmentation of transduction.
Human gene therapy 1999;10(4):591-602.
1999: John F Engelhardt
Redox-mediated gene therapies for environmental injury: approaches and concepts.
Antioxidants & redox signaling 1999;1(1):5-27.
1999: Dongsheng Duan; P Sharma; Lorita Dudus; Yulong Zhang; Salih Sanlioglu; Ziying Yan; Y Yue; Y Ye; R Lester; Jusan Yang; Krishna J Fisher; John F Engelhardt
Formation of adeno-associated virus circular genomes is differentially regulated by adenovirus E4 ORF6 and E2a gene expression.
Journal of virology 1999;73(1):161-9.
1998: Dongsheng Duan; Y Yue; Ziying Yan; Paul B McCray; John F Engelhardt
Polarity influences the efficiency of recombinant adenoassociated virus infection in differentiated airway epithelia.
Human gene therapy 1998;9(18):2761-76.
1998: Dongsheng Duan; P Sharma; Jusan Yang; Y Yue; Lorita Dudus; Yulong Zhang; Krishna J Fisher; John F Engelhardt
Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue.
Journal of virology 1998;72(11):8568-77.
1998: Ralf Michael Zwacka; Yulong Zhang; Weihong Zhou; J Halldorson; John F Engelhardt
Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation.
Hepatology (Baltimore, Md.) 1998;28(4):1022-30.
1998: P Sharma; Lorita Dudus; PA Nielsen; H Clausen; James R Yankaskas; M A Hollingsworth; John F Engelhardt
MUC5B and MUC7 are differentially expressed in mucous and serous cells of submucosal glands in human bronchial airways.
American journal of respiratory cell and molecular biology 1998;19(1):30-7.
1998: Xiang Fang; Neal L Weintraub; C D Rios; D A Chappell; Ralf Michael Zwacka; John F Engelhardt; L W Oberley; T Yan; Donald D Heistad; Arthur A Spector
Overexpression of human superoxide dismutase inhibits oxidation of low-density lipoprotein by endothelial cells.
Circulation research 1998;82(12):1289-97.
1998: Ralf Michael Zwacka; Lorita Dudus; M W Epperly; J S Greenberger; John F Engelhardt
Redox gene therapy protects human IB-3 lung epithelial cells against ionizing radiation-induced apoptosis.
Human gene therapy 1998;9(9):1381-6.
1998: Ralf Michael Zwacka; Weihong Zhou; Yulong Zhang; C J Darby; Lorita Dudus; J Halldorson; L Oberley; John F Engelhardt
Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-kappaB activation.
Nature medicine 1998;4(6):698-704.
1998: Dongsheng Duan; A Sehgal; J Yao; John F Engelhardt
Lef1 transcription factor expression defines airway progenitor cell targets for in utero gene therapy of submucosal gland in cystic fibrosis.
American journal of respiratory cell and molecular biology 1998;18(6):750-8.
1998: Yulong Zhang; Q Jiang; Lorita Dudus; James R Yankaskas; John F Engelhardt
Vector-specific complementation profiles of two independent primary defects in cystic fibrosis airways.
Human gene therapy 1998;9(5):635-48.
1997: Jean Bennett; D Duan; John F Engelhardt; Albert M Maguire
Real-time, noninvasive in vivo assessment of adeno-associated virus-mediated retinal transduction.
Investigative ophthalmology & visual science 1997;38(13):2857-63.
1997: Ralf Michael Zwacka; Yulong Zhang; J Halldorson; H Schlossberg; Lorita Dudus; John F Engelhardt
CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver.
The Journal of clinical investigation 1997;100(2):279-89.
1997: Dongsheng Duan; Krishna J Fisher; J F Burda; John F Engelhardt
Structural and functional heterogeneity of integrated recombinant AAV genomes.
Virus research 1997;48(1):41-56.
1997: A Presente; A Sehgal; Lorita Dudus; John F Engelhardt
Differentially regulated epithelial expression of an Eph family tyrosine kinase (fHek2) during tracheal surface airway and submucosal gland development.
American journal of respiratory cell and molecular biology 1997;16(1):53-61.
1996: A Sehgal; A Presente; Lorita Dudus; John F Engelhardt
Isolation of differentially expressed cDNAs during ferret tracheal development: application of differential display PCR.
Experimental lung research 1996;22(4):419-34.
1996: A Sehgal; A Presente; John F Engelhardt
Developmental expression patterns of CFTR in ferret tracheal surface airway and submucosal gland epithelia.
American journal of respiratory cell and molecular biology 1996;15(1):122-31.
1996: H Schlossberg; Yulong Zhang; Lorita Dudus; John F Engelhardt
Expression of c-fos and c-jun during hepatocellular remodeling following ischemia/reperfusion in mouse liver.
Hepatology (Baltimore, Md.) 1996;23(6):1546-55.
1995: Yulong Zhang; Benjamin J Doranz; James R Yankaskas; John F Engelhardt
Genotypic analysis of respiratory mucous sulfation defects in cystic fibrosis.
The Journal of clinical investigation 1995;96(6):2997-3004.
1995: John F Engelhardt; H Schlossberg; James R Yankaskas; Lorita Dudus
Progenitor cells of the adult human airway involved in submucosal gland development.
Development (Cambridge, England) 1995;121(7):2031-46.
1995: M J Goldman; Leslie A Litzky; John F Engelhardt; James M Wilson
Transfer of the CFTR gene to the lung of nonhuman primates with E1-deleted, E2a-defective recombinant adenoviruses: a preclinical toxicology study.
Human gene therapy 1995;6(7):839-51.
1994: John F Engelhardt; Leslie A Litzky; James M Wilson
Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a.
Human gene therapy 1994;5(10):1217-29.
1994: Y Yang; Frederick A Nunes; Klara Berencsi; Eva Gönczöl; John F Engelhardt; James M Wilson
Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis.
Nature genetics 1994;7(3):362-9.
1994: Y Yang; John F Engelhardt; James M Wilson
Ultrastructural localization of variant forms of cystic fibrosis transmembrane conductance regulator in human bronchial epithelial of xenografts.
American journal of respiratory cell and molecular biology 1994;11(1):7-15.
1994: John F Engelhardt; Xuehai Ye; Benjamin J Doranz; James M Wilson
Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):6196-200.
1994: M Grossman; Steven E Raper; Karen F Kozarsky; E A Stein; John F Engelhardt; D Muller; P J Lupien; James M Wilson
Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia.
Nature genetics 1994;6(4):335-41.
1994: James M Wilson; John F Engelhardt; M Grossman; Richard H Simon; Y Yang
Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: a phase I trial.
Human gene therapy 1994;5(4):501-19.
1994: John F Engelhardt; M Zepeda; Jonathan A Cohn; James R Yankaskas; James M Wilson
Expression of the cystic fibrosis gene in adult human lung.
The Journal of clinical investigation 1994;93(2):737-49.
1993: Richard H Simon; John F Engelhardt; Y Yang; M Zepeda; S Weber-Pendleton; M Grossman; James M Wilson
Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: toxicity study.
Human gene therapy 1993;4(6):771-80.
1993: John F Engelhardt; Richard H Simon; Y Yang; M Zepeda; S Weber-Pendleton; Benjamin J Doranz; M Grossman; James M Wilson
Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: biological efficacy study.
Human gene therapy 1993;4(6):759-69.
1993: Y Yang; D C Devor; John F Engelhardt; Stephen A Ernst; T V Strong; Francis S Collins; Jonathan A Cohn; R A Frizzell; James M Wilson
Molecular basis of defective anion transport in L cells expressing recombinant forms of CFTR.
Human molecular genetics 1993;2(8):1253-61.
1993: Y Yang; S E Raper; Jonathan A Cohn; John F Engelhardt; James M Wilson
An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4601-5.
1993: John F Engelhardt; Y Yang; L D Stratford-Perricaudet; E D Allen; Karen F Kozarsky; M Perricaudet; James R Yankaskas; James M Wilson
Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses.
Nature genetics 1993;4(1):27-34.
1992: John F Engelhardt; James R Yankaskas; James M Wilson
In vivo retroviral gene transfer into human bronchial epithelia of xenografts.
The Journal of clinical investigation 1992;90(6):2598-607.
1992: John F Engelhardt; James R Yankaskas; Stephen A Ernst; Y Yang; C R Marino; Richard C Boucher; Jonathan A Cohn; James M Wilson
Submucosal glands are the predominant site of CFTR expression in the human bronchus.
Nature genetics 1992;2(3):240-8.
1991: John F Engelhardt; E D Allen; James M Wilson
Reconstitution of tracheal grafts with a genetically modified epithelium.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11192-6.