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Lars Engman

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TOP 3
Jun Lu; Alexios Vlamis-Gardikas; Rong Zhao; Karuppasamy Kandasamy; Lars Engman; Lars Engstrand; Tomas N Gustafsson; Sven Hoffner; Arne Holmgren
Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione.
Vijay P Singh; Jia-fei Poon; Lars Engman
Turning pyridoxine into a catalytic chain-breaking and hydroperoxide-decomposing antioxidant.
Michelle Co; Lars Engman; Amelie Fagerlund; Per J R Sjöberg; Kerstin Sunnerheim; Charlotta Turner
Extraction of antioxidants from spruce (Picea abies) bark using eco-friendly solvents.

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All Publications

2013: Jun Lu; Alexios Vlamis-Gardikas; Rong Zhao; Karuppasamy Kandasamy; Lars Engman; Lars Engstrand; Tomas N Gustafsson; Sven Hoffner; Arne Holmgren
Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(4):1394-403.
2013: Vijay P Singh; Jia-fei Poon; Lars Engman
Turning pyridoxine into a catalytic chain-breaking and hydroperoxide-decomposing antioxidant.
The Journal of organic chemistry 2013;78(4):1478-87.
2012: Michelle Co; Lars Engman; Amelie Fagerlund; Per J R Sjöberg; Kerstin Sunnerheim; Charlotta Turner
Extraction of antioxidants from spruce (Picea abies) bark using eco-friendly solvents.
Phytochemical analysis : PCA 2012;23(1):1-11.
2010: Riccardo Amorati; Gian Franco Pedulli; Luca Valgimigli; Henrik Johansson; Lars Engman
Organochalcogen substituents in phenolic antioxidants.
Organic letters 2010;12(10):2326-9.
2010: Henrik Johansson; Olov Svartström; Prasad Phadnis; Lars Engman; Marjam Karlsson Ott
Exploring a synthetic organoselenium compound for antioxidant pharmacotherapy--toxicity and effects on ROS-production.
Bioorganic & medicinal chemistry 2010;18(5):1783-8.
2010: Sangit Kumar; Henrik Johansson; Takahiro Kanda; Lars Engman; Thomas Müller; Helena Bergenudd; Mats Jonsson; Gian Franco Pedulli; Riccardo Amorati; Luca Valgimigli
Catalytic chain-breaking pyridinol antioxidants.
The Journal of organic chemistry 2010;75(3):716-25.
2008: Sangit Kumar; Henrik Johansson; Takahiro Kanda; Lars Engman; Thomas Müller; Mats Jonsson; Gian Franco Pedulli; Silvia Petrucci; Luca Valgimigli
Catalytic chain-breaking pyridinol antioxidants.
Organic letters 2008;10(21):4895-8.
2007: Sangit Kumar; Lars Engman; Luca Valgimigli; Riccardo Amorati; Maria Grazia Fumo; Gian Franco Pedulli
Antioxidant profile of ethoxyquin and some of its S, Se, and Te analogues.
The Journal of organic chemistry 2007;72(16):6046-55.
2007: Sangit Kumar; Henrik Johansson; Lars Engman; Luca Valgimigli; Riccardo Amorati; Maria Grazia Fumo; Gian Franco Pedulli
Regenerable chain-breaking 2,3-dihydrobenzo[b]selenophene-5-ol antioxidants.
The Journal of organic chemistry 2007;72(7):2583-95.
2006: Sangit Kumar; Lars Engman
Microwave-assisted copper-catalyzed preparation of diaryl chalcogenides.
The Journal of organic chemistry 2006;71(14):5400-3.
2006: Lars Engman; Michael McNaughton; Malgorzata Gajewska; Sangit Kumar; Anne Birmingham; Garth Powis
Thioredoxin reductase and cancer cell growth inhibition by organogold(III) compounds.
Anti-cancer drugs 2006;17(5):539-44.
2006: David Shanks; Håkan Frisell; Henrik Ottosson; Lars Engman
Design principles for alpha-tocopherol analogues.
Organic & biomolecular chemistry 2006;4(5):846-52.
2006: David Shanks; Riccardo Amorati; Maria Grazia Fumo; Gian Franco Pedulli; Luca Valgimigli; Lars Engman
Synthesis and antioxidant profile of all-rac-alpha-selenotocopherol.
The Journal of organic chemistry 2006;71(3):1033-8.
2004: Cecilia Ericsson; Lars Engman
Microwave-assisted group-transfer cyclization of organotellurium compounds.
The Journal of organic chemistry 2004;69(15):5143-6.
2004: David Shanks; Sofia Berlin; Magnus Beşev; Henrik Ottosson; Lars Engman
On the origin of cis selectivity in the cyclization of N-protected 2-substituted 3-aza-5-hexenyl radicals: a density functional study.
The Journal of organic chemistry 2004;69(5):1487-91.
2004: Michael McNaughton; Lars Engman; Anne Birmingham; Garth Powis; Ian A Cotgreave
Cyclodextrin-derived diorganyl tellurides as glutathione peroxidase mimics and inhibitors of thioredoxin reductase and cancer cell growth.
Journal of medicinal chemistry 2004;47(1):233-9.
2003: Lars Engman; Nawaf Al-Maharik; Michael McNaughton; Anne Birmingham; Garth Powis
Thioredoxin reductase and cancer cell growth inhibition by organotellurium compounds that could be selectively incorporated into tumor cells.
Bioorganic & medicinal chemistry 2003;11(23):5091-100.
2003: Sofia Berlin; Cecilia Ericsson; Lars Engman
Radical carbonylation/reductive cyclization for the construction of tetrahydrofuran-3-ones and pyrrolidin-3-ones.
The Journal of organic chemistry 2003;68(22):8386-96.
2003: Lars Engman; Nawaf Al-Maharik; Michael McNaughton; Anne Birmingham; Garth Powis
Thioredoxin reductase and cancer cell growth inhibition by organotellurium antioxidants.
Anti-cancer drugs 2003;14(2):153-61.
2003: Katharina Bratt; Kerstin Sunnerheim; Susanne Bryngelsson; Amelie Fagerlund; Lars Engman; Rolf E Andersson; Lena H Dimberg
Avenanthramides in oats (Avena sativa L.) and structure-antioxidant activity relationships.
Journal of agricultural and food chemistry 2003;51(3):594-600.
2002: Magnus Besev; Lars Engman
Diastereocontrol by a hydroxyl auxiliary in the synthesis of pyrrolidines via radical cyclization.
Organic letters 2002;4(18):3023-5.
2002: Sofia Berlin; Cecilia Ericsson; Lars Engman
Construction of tetrahydrofuran-3-ones from readily available organochalcogen precursors via radical carbonylation/reductive cyclization.
Organic letters 2002;4(1):3-6.
2001: Cecilia Ericsson; Lars Engman
Diastereocontrol by trialkylaluminums in the synthesis of tetrahydrofurans via radical cyclization.
Organic letters 2001;3(22):3459-62.
2001: Nawaf Al-Maharik; Lars Engman; Jonas Malmström; C H Schiesser
Intramolecular homolytic substitution at selenium: synthesis of novel selenium-containing vitamin E analogues.
The Journal of organic chemistry 2001;66(19):6286-90.
2001: Jonas Malmström; M Jonsson; Ian A Cotgreave; Leif Hammarström; M Sjödin; Lars Engman
The antioxidant profile of 2,3-dihydrobenzo[b]furan-5-ol and its 1-thio, 1-seleno, and 1-telluro analogues.
Journal of the American Chemical Society 2001;123(15):3434-40.
2000: Lars Engman; T Kandra; Alfred Gallegos; R Williams; Garth Powis
Water-soluble organotellurium compounds inhibit thioredoxin reductase and the growth of human cancer cells.
Anti-cancer drug design 2000;15(5):323-30.
2000: C Jacob; Gavin E Arteel; T Kanda; Lars Engman; Helmut Sies
Water-soluble organotellurium compounds: catalytic protection against peroxynitrite and release of zinc from metallothionein.
Chemical research in toxicology 2000;13(1):3-9.
1999: P Garberg; Lars Engman; Vladimir Tolmachev; H Lundqvist; Robert Gerdes; Ian A Cotgreave
Binding of tellurium to hepatocellular selenoproteins during incubation with inorganic tellurite: consequences for the activity of selenium-dependent glutathione peroxidase.
The international journal of biochemistry & cell biology 1999;31(2):291-301.
1998: K Briviba; R Tamler; Lars-Oliver Klotz; Lars Engman; Ian A Cotgreave; Helmut Sies
Protection by organotellurium compounds against peroxynitrite-mediated oxidation and nitration reactions.
Biochemical pharmacology 1998;55(6):817-23.
1997: Lars Engman; Ian A Cotgreave; M Angulo; C W Taylor; Gillian Paine-Murrieta; Garth Powis
Diaryl chalcogenides as selective inhibitors of thioredoxin reductase and potential antitumor agents.
Anticancer research 1997;17(6D):4599-605.
1997: Garth Powis; JR Gasdaska; PY Gasdaska; Margareta I Berggren; D Lynn Kirkpatrick; Lars Engman; Ian A Cotgreave; M Angulo; Amanda Baker
Selenium and the thioredoxin redox system: effects on cell growth and death.
Oncology research 1997;9(6-7):303-12.
1995: Lars Engman; J Persson; K Vessman; M Ekström; M Berglund; C M Andersson
Organotellurium compounds as efficient retarders of lipid peroxidation in methanol.
Free radical biology & medicine 1995;19(4):441-52.
1995: Lars Engman; D Stern; H Frisell; K Vessman; M Berglund; B Ek; C M Andersson
Synthesis, antioxidant properties, biological activity and molecular modelling of a series of chalcogen analogues of the 5-lipoxygenase inhibitor DuP 654.
Bioorganic & medicinal chemistry 1995;3(9):1255-62.
1995: Jing Hu; Lars Engman; Ian A Cotgreave
Redox-active chalcogen-containing glutathione peroxidase mimetics and antioxidants inhibit tumour promoter-induced downregulation of gap junctional intercellular communication between WB-F344 liver epithelial cells.
Carcinogenesis 1995;16(8):1815-24.
1995: G Bannenberg; J Xue; Lars Engman; Ian A Cotgreave; P Moldéus; Ake Ryrfeldt
Characterization of bronchodilator effects and fate of S-nitrosothiols in the isolated perfused and ventilated guinea pig lung.
The Journal of pharmacology and experimental therapeutics 1995;272(3):1238-45.
1994: Lars Engman; A Tunek; M Hallberg; Anders Hallberg
Catalytic effects of glutathione peroxidase mimetics on the thiol reduction of cytochrome c.
Chemico-biological interactions 1994;93(2):129-37.
1994: C M Andersson; Ralph Brattsand; Anders Hallberg; Lars Engman; J Persson; P Moldéus; Ian A Cotgreave
Diaryl tellurides as inhibitors of lipid peroxidation in biological and chemical systems.
Free radical research 1994;20(6):401-10.
1992: Ralf Morgenstern; Ian A Cotgreave; Lars Engman
Determination of the relative contributions of the diselenide and selenol forms of ebselen in the mechanism of its glutathione peroxidase-like activity.
Chemico-biological interactions 1992;84(1):77-84.
1992: Ian A Cotgreave; Ralf Morgenstern; Lars Engman; J Ahokas
Characterisation and quantitation of a selenol intermediate in the reaction of ebselen with thiols.
Chemico-biological interactions 1992;84(1):69-76.
1992: Ian A Cotgreave; P Moldéus; Ralph Brattsand; Anders Hallberg; C M Andersson; Lars Engman
Alpha-(phenylselenenyl)acetophenone derivatives with glutathione peroxidase-like activity. A comparison with ebselen.
Biochemical pharmacology 1992;43(4):793-802.
1991: Ian A Cotgreave; P Moldéus; Lars Engman; Anders Hallberg
The correlation of the oxidation potentials of structurally related dibenzo[1,4]dichalcogenines to their antioxidance capacity in biological systems undergoing free radical-induced lipid peroxidation.
Biochemical pharmacology 1991;42(7):1481-5.