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Caroline Enns

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Anatomy

Physiology

Disorders

Hemochromatosis

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequence

Living Beings

Mice

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Network (preview)

Co-Publications
Name
11
Zhang, An-Sheng
9
Sussman, Howard
5
So, Magdalene
5
ROY, CINDY
5
Bjorkman, Pamela
5
Chen, Juxing
4
Davies, Paige
4
Lucas, John
3
Green, Frank
3
Hayes, Gary
3
Feder, JN
3
Carlson, Hanqian
3
Bonnah, Robert
3
Anderson, Emily
3
Gao, Junwei

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Publications

TOP 3
Chen Juxing; Wang Jinzhi; Meyers Kathrin R; Enns Caroline A
Transferrin-directed internalization and cycling of transferrin receptor 2.
Zhang An-Sheng; Yang Fan; Wang Jiaohong; Tsukamoto Hidekazu; Enns Caroline A
Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression.
Gao Junwei; Chen Juxing; Kramer Maxwell; Tsukamoto Hidekazu; Zhang An-Sheng; Enns Caroline A
Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression.

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All Publications

2009: Chen Juxing; Wang Jinzhi; Meyers Kathrin R; Enns Caroline A
Transferrin-directed internalization and cycling of transferrin receptor 2.
Traffic (Copenhagen, Denmark) 2009;10(10):1488-501.
2009: Zhang An-Sheng; Yang Fan; Wang Jiaohong; Tsukamoto Hidekazu; Enns Caroline A
Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression.
The Journal of biological chemistry 2009;284(34):22580-9.
2009: Gao Junwei; Chen Juxing; Kramer Maxwell; Tsukamoto Hidekazu; Zhang An-Sheng; Enns Caroline A
Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression.
Cell metabolism 2009;9(3):217-27.
2009: Maxson Julia E; Enns Caroline A; Zhang An-Sheng
Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells.
Blood 2009;113(8):1786-93.
2009: Zhang An-Sheng; Enns Caroline A
Iron homeostasis: recently identified proteins provide insight into novel control mechanisms.
The Journal of biological chemistry 2009;284(2):711-5.
2008: Xiong Shigang; She Hongyun; Zhang An-Sheng; Wang Jiaohong; Mkrtchyan Hasmik; Dynnyk Alla; Gordeuk Victor R; French Samuel W; Enns Caroline A; Tsukamoto Hidekazu
Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis.
American journal of physiology. Gastrointestinal and liver physiology 2008;295(3):G512-21.
2008: Gao Junwei; Zhao Ningning; Knutson Mitchell D; Enns Caroline A
The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells.
The Journal of biological chemistry 2008;283(31):21462-8.
2008: Zhang An-Sheng; Yang Fan; Meyer Kathrin; Hernandez Catalina; Chapman-Arvedson Tara; Bjorkman Pamela J; Enns Caroline A
Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane.
The Journal of biological chemistry 2008;283(25):17494-502.
2007: Chen Juxing; Chloupková Maja; Gao Junwei; Chapman-Arvedson Tara L; Enns Caroline A
HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.
The Journal of biological chemistry 2007;282(51):36862-70.
2007: Zhang An-Sheng; Anderson Sheila A; Meyers Kathrin R; Hernandez Catalina; Eisenstein Richard S; Enns Caroline A
Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin.
The Journal of biological chemistry 2007;282(17):12547-56.
2007: Chen Juxing; Enns Caroline A
The Cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells.
The Journal of biological chemistry 2007;282(9):6201-9.
2007: Johnson Martha B; Chen Juxing; Murchison Nicholas; Green Frank A; Enns Caroline A
Transferrin receptor 2: evidence for ligand-induced stabilization and redirection to a recycling pathway.
Molecular biology of the cell 2007;18(3):743-54.
2006: Enns Caroline A
Possible roles of the hereditary hemochromatosis protein, HFE, in regulating cellular iron homeostasis.
Biological research 2006;39(1):105-11.
2005: Giannetti Anthony M; Halbrooks Peter J; Mason Anne B; Vogt Todd M; Enns Caroline A; Björkman Pamela J
The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin.
Structure (London, England : 1993) 2005;13(11):1613-23.
2005: Zhang An-Sheng; West Anthony P; Wyman Anne E; Bjorkman Pamela J; Enns Caroline A
Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells.
The Journal of biological chemistry 2005;280(40):33885-94.
2005: Bonnah Robert A; Hoelter Jenny; Steeghs Liana; Enns Caroline A; So Magdalene; Muckenthaler Martina U
Lipooligosaccharide-independent alteration of cellular homeostasis in Neisseria meningitidis-infected epithelial cells.
Cellular microbiology 2005;7(6):869-85.
2005: Carlson Hanqian; Zhang An-Sheng; Fleming William H; Enns Caroline A
The hereditary hemochromatosis protein, HFE, lowers intracellular iron levels independently of transferrin receptor 1 in TRVb cells.
Blood 2005;105(6):2564-70.
2004: Johnson Martha B; Enns Caroline A
Diferric transferrin regulates transferrin receptor 2 protein stability.
Blood 2004;104(13):4287-93.
2004: Davies Paige S; Enns Caroline A
Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells.
The Journal of biological chemistry 2004;279(24):25085-92.
2004: Bonnah Robert A; Muckenthaler Martina U; Carlson Hanqian; Minana Belen; Enns Caroline A; Hentze Matthias W; So Magdalene
Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis.
Cellular microbiology 2004;6(5):473-84.
2004: Zhang An-Sheng; Xiong Shigang; Tsukamoto Hidekazu; Enns Caroline A
Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes.
Blood 2004;103(4):1509-14.
2003: Zhang An-Sheng; Davies Paige S; Carlson Hanqian L; Enns Caroline A
Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9500-5.
2003: Davies Paige S; Zhang An-Sheng; Anderson Emily L; Roy Cindy N; Lampson Michael A; McGraw Timothy E; Enns Caroline A
Evidence for the interaction of the hereditary haemochromatosis protein, HFE, with the transferrin receptor in endocytic compartments.
The Biochemical journal 2003;373(Pt 1):145-53.
2003: Vogt Todd M; Blackwell Aaron D; Giannetti Anthony M; Bjorkman Pamela J; Enns Caroline A
Heterotypic interactions between transferrin receptor and transferrin receptor 2.
Blood 2003;101(5):2008-14.
2002: Green Frank; O'Hare Thomas; Blackwell Aaron; Enns Caroline A
Association of human transferrin receptor with GABARAP.
FEBS letters 2002;518(1-3):101-6.
2002: Roy Cindy N; Blemings Kenneth P; Deck Kathryn M; Davies Paige S; Anderson Emily L; Eisenstein Richard S; Enns Caroline A
Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells.
Journal of cellular physiology 2002;190(2):218-26.
2001: Aisen P; Enns C; Wessling-Resnick M
Chemistry and biology of eukaryotic iron metabolism.
The international journal of biochemistry & cell biology 2001;33(10):940-59.
2001: Enns C
Overview of protein trafficking in the secretory and endocytic pathways.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2001;Chapter 15():Unit 15.1.
2001: Enns C A
Pumping iron: the strange partnership of the hemochromatosis protein, a class I MHC homolog, with the transferrin receptor.
Traffic (Copenhagen, Denmark) 2001;2(3):167-74.
2000: Ramalingam T S; West A P; Lebrón J A; Nangiana J S; Hogan T H; Enns C A; Bjorkman P J
Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis.
Nature cell biology 2000;2(12):953-7.
2000: Roy C N; Enns C A
Iron homeostasis: new tales from the crypt.
Blood 2000;96(13):4020-7.
2000: West A P; Bennett M J; Sellers V M; Andrews N C; Enns C A; Bjorkman P J
Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE.
The Journal of biological chemistry 2000;275(49):38135-8.
2000: Roy C N; Carlson E J; Anderson E L; Basava A; Starnes S M; Feder J N; Enns C A
Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells.
FEBS letters 2000;484(3):271-4.
2000: Bonnah R A; Lee S W; Vasquez B L; Enns C A; So M
Alteration of epithelial cell transferrin-iron homeostasis by Neisseria meningitidis and Neisseria gonorrhoeae.
Cellular microbiology 2000;2(3):207-18.
1999: O'Hare T; Wiens G D; Whitcomb E A; Enns C A; Rittenberg M B
Cutting edge: proteasome involvement in the degradation of unassembled Ig light chains.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):11-4.
1999: Merz A J; Enns C A; So M
Type IV pili of pathogenic Neisseriae elicit cortical plaque formation in epithelial cells.
Molecular microbiology 1999;32(6):1316-32.
1999: Roy C N; Penny D M; Feder J N; Enns C A
The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells.
The Journal of biological chemistry 1999;274(13):9022-8.
1998: Gross C N; Irrinki A; Feder J N; Enns C A
Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation.
The Journal of biological chemistry 1998;273(34):22068-74.
1998: Warren R A; Green F A; Stenberg P E; Enns C A
Distinct saturable pathways for the endocytosis of different tyrosine motifs.
The Journal of biological chemistry 1998;273(27):17056-63.
1998: Rutledge E A; Gaston I; Root B J; McGraw T E; Enns C A
The transferrin receptor cytoplasmic domain determines its rate of transport through the biosynthetic pathway and its susceptibility to cleavage early in the pathway.
The Journal of biological chemistry 1998;273(20):12169-75.
1997: Liu G; Thomas L; Warren R A; Enns C A; Cunningham C C; Hartwig J H; Thomas G
Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway.
The Journal of cell biology 1997;139(7):1719-33.
1997: Lin L; Ayala P; Larson J; Mulks M; Fukuda M; Carlsson S R; Enns C; So M
The Neisseria type 2 IgA1 protease cleaves LAMP1 and promotes survival of bacteria within epithelial cells.
Molecular microbiology 1997;24(5):1083-94.
1997: Hayes G R; Williams A M; Lucas J J; Enns C A
Structure of human transferrin receptor oligosaccharides: conservation of site-specific processing.
Biochemistry 1997;36(17):5276-84.
1997: Warren R A; Green F A; Enns C A
Saturation of the endocytic pathway for the transferrin receptor does not affect the endocytosis of the epidermal growth factor receptor.
The Journal of biological chemistry 1997;272(4):2116-21.
1996: Rutledge E A; Enns C A
Cleavage of the transferrin receptor is influenced by the composition of the O-linked carbohydrate at position 104.
Journal of cellular physiology 1996;168(2):284-93.
1995: Hayes G R; Williams A; Costello C E; Enns C A; Lucas J J
The critical glycosylation site of human transferrin receptor contains a high-mannose oligosaccharide.
Glycobiology 1995;5(2):227-32.
1994: Rutledge E A; Green F A; Enns C A
Generation of the soluble transferrin receptor requires cycling through an endosomal compartment.
The Journal of biological chemistry 1994;269(50):31864-8.
1994: Rutledge E A; Root B J; Lucas J J; Enns C A
Elimination of the O-linked glycosylation site at Thr 104 results in the generation of a soluble human-transferrin receptor.
Blood 1994;83(2):580-6.
1993: Williams A M; Enns C A
A region of the C-terminal portion of the human transferrin receptor contains an asparagine-linked glycosylation site critical for receptor structure and function.
The Journal of biological chemistry 1993;268(17):12780-6.
1992: Hayes G R; Enns C A; Lucas J J
Identification of the O-linked glycosylation site of the human transferrin receptor.
Glycobiology 1992;2(4):355-9.
1991: Williams A M; Enns C A
A mutated transferrin receptor lacking asparagine-linked glycosylation sites shows reduced functionality and an association with binding immunoglobulin protein.
The Journal of biological chemistry 1991;266(26):17648-54.
1991: Enns C A; Clinton E M; Reckhow C L; Root B J; Do S I; Cook C
Acquisition of the functional properties of the transferrin receptor during its biosynthesis.
The Journal of biological chemistry 1991;266(20):13272-7.
1990: Do S I; Enns C; Cummings R D
Human transferrin receptor contains O-linked oligosaccharides.
The Journal of biological chemistry 1990;265(1):114-25.
1990: Vestal D J; Davis B H; Enns C A
A rapid redistribution of the transferrin receptor to the cell surface of HL-60 cells and K562 cells upon treatment with dimethyl sulfoxide due to slowing of endocytosis.
Archives of biochemistry and biophysics 1990;276(1):278-84.
1988: Root B J; Reckhow C L; Clinton E M; Enns C A
Characterization of proteins that associate with an unglycosylated form of the transferrin receptor in A431 cells.
The Journal of biological chemistry 1988;263(35):19071-6.
1988: Reckhow C L; Enns C A
Characterization of the transferrin receptor in tunicamycin-treated A431 cells.
The Journal of biological chemistry 1988;263(15):7297-301.
1988: Enns C A; Mulkins M A; Sussman H; Root B
Modulation of the transferrin receptor during DMSO-induced differentiation in HL-60 cells.
Experimental cell research 1988;174(1):89-97.
1987: Enns C A; Chan W W
Chemical stabilization of conformational states of aspartate transcarbamoylase.
Methods in enzymology 1987;135():569-77.
1985: Larrick J W; Enns C; Raubitschek A; Weintraub H
Receptor-mediated endocytosis of human transferrin and its cell surface receptor.
Journal of cellular physiology 1985;124(2):283-7.
1984: Nikinmaa B; Enns C A; Tonik S E; Sussman H H; Schröder J
Monoclonal antibodies to a purified human transferrin receptor.
Scandinavian journal of immunology 1984;20(5):441-7.
1983: Enns C A; Larrick J W; Suomalainen H; Schroder J; Sussman H H
Co-migration and internalization of transferrin and its receptor on K562 cells.
The Journal of cell biology 1983;97(2):579-85.
1983: Behrens C M; Enns C A; Sussman H H
Characterization of human foetal intestinal alkaline phosphatase. Comparison with the isoenzymes from the adult intestine and human tumour cell lines.
The Biochemical journal 1983;211(3):553-8.
1983: Plowman G D; Brown J P; Enns C A; Schröder J; Nikinmaa B; Sussman H H; Hellström K E; Hellström I
Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3.
Nature 1983;303(5912):70-2.
1982: Enns C A; Suomalainen H A; Gebhardt J E; Schröder J; Sussman H H
Human transferrin receptor: expression of the receptor is assigned to chromosome 3.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(10):3241-5.
1981: Enns C A; Sussman H H
Similarities between the transferrin receptor proteins on human reticulocytes and human placentae.
The Journal of biological chemistry 1981;256(24):12620-3.
1981: Enns C A; Sussman H H
Physical characterization of the transferrin receptor in human placentae.
The Journal of biological chemistry 1981;256(19):9820-3.
1981: Enns C A; Shindelman J E; Tonik S E; Sussman H H
Radioimmunochemical measurement of the transferrin receptor in human trophoblast and reticulocyte membranes with a specific anti-receptor antibody.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(7):4222-5.
1981: Chan W W; Enns C A
Hybrid aspartate transcarbamoylase containing cross-linked subunits.
Canadian journal of biochemistry 1981;59(6):461-8.
1981: Enns C A; Sussman H H
Characterization of the transferrin-binding protein in a human trophoblast.
Placenta. Supplement 1981;3():23-32.
1979: Enns C A; Chan W W
Conformational states of aspartate transcarbamoylase stabilized with a cross-linking reagent.
The Journal of biological chemistry 1979;254(13):6180-6.
1979: Chan W W; Enns C A
Aspartate transcarbamoylase: loss of homotropic but not heterotropic interactions upon modification of the catalytic subunit with a bifunctional reagent.
Canadian journal of biochemistry 1979;57(6):798-805.
1978: Chan W W; Enns C A
Structure and function of aspartate transcarbamoylase studied using chymotrypsin as a probe.
Canadian journal of biochemistry 1978;56(6):654-8.
1978: Enns C A; Chan W W
Stabilization of the relaxed state of aspartate transcarbamoylase by modification with a bifunctional reagent.
The Journal of biological chemistry 1978;253(8):2511-3.
1975: Kaneshiro C M; Enns C A; Hahn M G; Peterson J S; Reithel F J
Evidence for an active dimer of Escherichia coli beta-galactosidase.
The Biochemical journal 1975;151(2):433-4.

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