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Albert Enz

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TOP 3
Thomas Troxler; Konstanze Hurth; Henri Mattes; Mahavir Prashad; Philippe Schoeffter; Daniel Langenegger; Albert Enz; Daniel Hoyer
Discovery of novel non-peptidic beta-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists.
Albert Enz; Dominik Feuerbach; Mathias U Frederiksen; Conrad Gentsch; Konstanze Hurth; Werner Müller; Joachim Nozulak; Bernard L Roy
Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.
Dominik Feuerbach; Kurt Lingenhoehl; Hans-Rudolf Olpe; Annick Vassout; Conrad Gentsch; Frederique CHAPERON; Joachim Nozulak; Albert Enz; Graeme Bilbe; Kevin H McAllister; Daniel Hoyer
The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain.

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All Publications

2009: Thomas Troxler; Konstanze Hurth; Henri Mattes; Mahavir Prashad; Philippe Schoeffter; Daniel Langenegger; Albert Enz; Daniel Hoyer
Discovery of novel non-peptidic beta-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists.
Bioorganic & medicinal chemistry letters 2009;19(5):1305-9.
2009: Albert Enz; Dominik Feuerbach; Mathias U Frederiksen; Conrad Gentsch; Konstanze Hurth; Werner Müller; Joachim Nozulak; Bernard L Roy
Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.
Bioorganic & medicinal chemistry letters 2009;19(5):1287-91.
2009: Dominik Feuerbach; Kurt Lingenhoehl; Hans-Rudolf Olpe; Annick Vassout; Conrad Gentsch; Frederique CHAPERON; Joachim Nozulak; Albert Enz; Graeme Bilbe; Kevin H McAllister; Daniel Hoyer
The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain.
Neuropharmacology 2009;56(1):254-63.
2008: Thomas Troxler; Albert Enz; Daniel Hoyer; Daniel Langenegger; Peter Neumann; Paul Pfäffli; Philippe Schoeffter; Konstanze Hurth
Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst 1 receptor.
Bioorganic & medicinal chemistry letters 2008;18(3):979-82.
2007: Konstanze Hurth; Albert Enz; Philipp Floersheim; Conrad Gentsch; Daniel Hoyer; Daniel Langenegger; Peter Neumann; Paul Pfäffli; Dieter Sorg; Robert Swoboda; Annick Vassout; Thomas Troxler
SAR of the arylpiperazine moiety of obeline somatostatin sst1 receptor antagonists.
Bioorganic & medicinal chemistry letters 2007;17(14):3988-91.
2005: Martin Rausch; Conrad Gentsch; Albert Enz; Diana Baumann; Markus Rudin
A study paradigm allowing comparison of multiple high-resolution rCBV-maps for the examination of drug effects.
NMR in biomedicine 2005;18(4):260-8.
2005: Martin Hintersteiner; Albert Enz; Peter Frey; Anne-Lise Jaton; Willy Kinzy; Rainer Kneuer; Ulf Neumann; Markus Rudin; Matthias Staufenbiel; Markus Stoeckli; Karl-Heinz Wiederhold; Hans-Ulrich Gremlich
In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe.
Nature biotechnology 2005;23(5):577-83.
2005: Josefine Andin; Albert Enz; Conrad Gentsch; Jan Marcusson
Rivastigmine as a modulator of the neuronal glutamate transporter rEAAC1 mRNA expression.
Dementia and geriatric cognitive disorders 2005;19(1):18-23.
2004: Albert Enz; Conrad Gentsch
Co-administration of memantine has no effect on the in vitro or ex vivo determined acetylcholinesterase inhibition of rivastigmine in the rat brain.
Neuropharmacology 2004;47(3):408-13.
2002: Sonia Boncristiano; Michael E Calhoun; Peter Kelly; Michelle Pfeifer; Luca Bondolfi; Martina Stalder; Amie L Phinney; Dorothee Abramowski; Christine Sturchler-Pierrat; Albert Enz; Bernd Sommer; Matthias Staufenbiel; Mathias Jucker
Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(8):3234-43.