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Michael Epperly

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Ronny Kalash; Melissa M Sprachman; Hong Wang; Peter Wipf; Xichen Zhang; Hebist Berhane; Tracy Dixon; Michael W Epperly; Darcy Franicola; Julie Goff; Frank Houghton; Joel S Greenberger
Effects of Thoracic Irradiation on Pulmonary Endothelial Compared to Alveolar Type-II Cells in Fibrosis-Prone C57BL/6NTac Mice.
Michael W Epperly; Nathan Bahary; Valerie Dewald; Mubina Quader; Joel S Greenberger
The zebrafish--Danio rerio--is a useful model for measuring the effects of small-molecule mitigators of late effects of ionizing irradiation.
Alejandro K Samhan-Arias; Anna A Shvedova; Louis J Sparvero; Vladimir A Tyurin; Yulia Y Tyurina; Hülya Bayır; Olga M Demidova; Michael W Epperly; Weihong Feng; Joel S Greenberger; Jing Ji; Valerian E Kagan; Andrew A Amoscato
Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin.

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2013: Ronny Kalash; Melissa M Sprachman; Hong Wang; Peter Wipf; Xichen Zhang; Hebist Berhane; Tracy Dixon; Michael W Epperly; Darcy Franicola; Julie Goff; Frank Houghton; Joel S Greenberger
Effects of Thoracic Irradiation on Pulmonary Endothelial Compared to Alveolar Type-II Cells in Fibrosis-Prone C57BL/6NTac Mice.
In vivo (Athens, Greece) 2013;27(3):291-7.
2012: Michael W Epperly; Nathan Bahary; Valerie Dewald; Mubina Quader; Joel S Greenberger
The zebrafish--Danio rerio--is a useful model for measuring the effects of small-molecule mitigators of late effects of ionizing irradiation.
In vivo (Athens, Greece) 2012;26(6):889-97.
2012: Alejandro K Samhan-Arias; Anna A Shvedova; Louis J Sparvero; Vladimir A Tyurin; Yulia Y Tyurina; Hülya Bayır; Olga M Demidova; Michael W Epperly; Weihong Feng; Joel S Greenberger; Jing Ji; Valerian E Kagan; Andrew A Amoscato
Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin.
Biochimica et biophysica acta 2012;1818(10):2413-23.
2012: Crystal D Zellefrow; Michael W Epperly; Joel S Greenberger; Ana Lira; Celeste E Reese; Elizabeth R Sharlow; Tongying Shun; John S Lazo
Identification of druggable targets for radiation mitigation using a small interfering RNA screening assay.
Radiation research 2012;178(3):150-9.
2012: Regina P O'Sullivan; Hong Wang; Shuanhu Zhou; Shaonan Cao; Tracy Dixon; Michael W Epperly; Julie Goff; Joel S Greenberger; Frank D Houghton; Kiera A Kingston; Julie Glowacki
Dysregulated in vitro hematopoiesis, radiosensitivity, proliferation, and osteoblastogenesis with marrow from SAMP6 mice.
Experimental hematology 2012;40(6):499-509.
2012: Linda L Pearce; Xichen Zheng; Michael W Epperly; Mitchell P Fink; Joel S Greenberger; Patrick P Kerr; Pornsri Khlangwiset; Sandra Martinez-Bosch; Jim Peterson
L-arginine is a radioprotector for hematopoietic progenitor cells.
Radiation research 2012;177(6):792-803.
2012: Hyun Kim; Donna Shields; Hong Wang; Xichen Zhang; Frank Houghton; Ronny Kalash; Mark E Bernard; Murat Can Cobanoglu; Tracy Dixon; Michael W Epperly; Amy Farkas; Darcy Franicola; Julie Goff; Joel S Greenberger
Ionizing irradiation protection and mitigation of murine cells by carbamazepine is p53 and autophagy independent.
In vivo (Athens, Greece) 2012;26(3):341-54.
2011: Mark E Bernard; Tracy Dixon; Michael W Epperly; Eric E Kelley; Hyun Kim; Geoffery H Murdoch; Jean-Claude Rwigema; Hong Wang; Joel S Greenberger
Role of the esophageal vagus neural pathway in ionizing irradiation-induced seizures in nitric oxide synthase-1 homologous recombinant negative NOS1-/- mice.
In vivo (Athens, Greece) 2011;25(6):861-9.
2011: Hyun Kim; Song Li; Hongmei Shen; Hong Wang; Peter Wipf; Xichen Zhang; Andrew Amoscato; Mark E Bernard; Tracy M Dixon; Alexander S Doemling; Michael W Epperly; Xiang Gao; Valerian E Kagan; Joel S Greenberger
Amelioration of radiation esophagitis by orally administered p53/Mdm2/Mdm4 inhibitor (BEB55) or GS-nitroxide.
In vivo (Athens, Greece) 2011;25(6):841-8.
2011: Mark E Bernard; Michael W Epperly; Erin M Forbeck; Darcy Franicola; Marie-Celine Frantz; Julie P Goff; Frank Houghton; Hyun Kim; Donna Shields; Hong Wang; Peter Wipf; Xichen Zhang; Christopher J Bakkenist; Hebist Berhane; Joel S Greenberger
GS-nitroxide (JP4-039)-mediated radioprotection of human Fanconi anemia cell lines.
Radiation research 2011;176(5):603-12.
2011: Hyun Kim; Donna Shields; Hong Wang; Xichen Zhang; Mark E Bernard; Tracy M Dixon; Michael W Epperly; John Flickinger; Frank Houghton; Joel S Greenberger
The autophagy-inducing drug carbamazepine is a radiation protector and mitigator.
International journal of radiation biology 2011;87(10):1052-60.
2011: Kirsi Jahnukainen; Mirja Nurmio; Mubina A Quader; M Saiful Huq; Jens Ehmcke; Michael W Epperly; Scott Hergenrother; Stefan Schlatt
Testicular recovery after irradiation differs in prepubertal and pubertal non-human primates, and can be enhanced by autologous germ cell transplantation.
Human reproduction (Oxford, England) 2011;26(8):1945-54.
2011: Jean-Claude M Rwigema; Barbara Beck; Wei Wang; Alexander Doemling; Michael W Epperly; Donna Shields; Julie P Goff; Darcy Franicola; Tracy Dixon; Marie-Céline Frantz; Peter Wipf; Yulia Tyurina; Valerian E Kagan; Hong Wang; Joel S Greenberger
Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators.
International journal of radiation oncology, biology, physics 2011;80(3):860-8.
2011: Michael W Epperly; Hong Wang; Jeffrey A Jones; Tracy Dixon; Carlos A Montesinos; Joel S Greenberger
Antioxidant-chemoprevention diet ameliorates late effects of total-body irradiation and supplements radioprotection by MnSOD-plasmid liposome administration.
Radiation research 2011;175(6):759-65.
2011: Julie P Goff; Michael W Epperly; Tracy Dixon; Hong Wang; Darcy Franicola; Donna Shields; Peter Wipf; Song Li; Xiang Gao; Joel S Greenberger
Radiobiologic effects of GS-nitroxide (JP4-039) on the hematopoietic syndrome.
In vivo (Athens, Greece) 2011;25(3):315-23.
2011: Ahmad A Tarhini; Chandra P Belani; James D Luketich; Athanassios Argiris; Suresh S Ramalingam; William Gooding; Arjun Pennathur; Daniel Petro; Kevin Kane; Denny Liggitt; Tony Championsmith; Xichen Zhang; Michael W Epperly; Joel S Greenberger
A phase I study of concurrent chemotherapy (paclitaxel and carboplatin) and thoracic radiotherapy with swallowed manganese superoxide dismutase plasmid liposome protection in patients with locally advanced stage III non-small-cell lung cancer.
Human gene therapy 2011;22(3):336-42.
2011: Joel S Greenberger; Valerian Kagan; John S Lazo; Song Li; Peter Wipf; Hülya Bayir; David Clump; Xiang Gao; Michael W Epperly
Strategies for discovery of small molecule radiation protectors and radiation mitigators.
Frontiers in oncology 2011;1():59.
2011: Jeffrey Atkinson; Hülya Bayîr; Natalia A Belikova; Michael W Epperly; Weihong Feng; Jackie Fletcher; Joel S Greenberger; Zhentai Huang; Jianfei Jiang; Alexandr A Kapralov; Judith Klein-Seetharaman; Akihiro Maeda; Linda Pearce; Jim Peterson; Bruce R Pitt; Alejandro K Samhan-Arias; Detcho A Stoyanovsky; Vladimir A Tyurin; Yulia Y Tyurina; Irina I Vlasova; Hong Wang; Yongsheng Wang; Karla Wasserloos; Naveena Yanamala; Andrew A Amoscato; Valerian E Kagan
A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death.
Nature communications 2011;2():497.
2010: Michael W Epperly; Julie P Goff; Song Li; Xiang Gao; Peter Wipf; Tracy Dixon; Hong Wang; Darcy Franicola; Hongmei Shen; Jean-Claude M Rwigema; Valerian Kagan; Mark Bernard; Joel S Greenberger
Intraesophageal administration of GS-nitroxide (JP4-039) protects against ionizing irradiation-induced esophagitis.
In vivo (Athens, Greece) 2010;24(6):811-9.
2010: S Eghtesad; H Zheng; Hiroyuki Nakai; Michael W Epperly; Paula R Clemens
Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity.
Gene therapy 2010;17(9):1181-90.
2010: Malolan S Rajagopalan; Brandon Stone; Jean-Claude Rwigema; Umar Salimi; Michael W Epperly; Julie Goff; Darcy Franicola; Tracy Dixon; Shaonan Cao; Xichen Zhang; Bettina M Buchholz; Anthony J Bauer; Serah Choi; Christopher J Bakkenist; Hong Wang; Joel S Greenberger
Intraesophageal manganese superoxide dismutase-plasmid liposomes ameliorates novel total-body and thoracic radiation sensitivity of NOS1-/- mice.
Radiation research 2010;174(3):297-312.
2010: Abhay Gokhale; Jean-Claude Rwigema; Michael W Epperly; Julie Glowacki; Hong Wang; Peter Wipf; Julie P Goff; Tracy Dixon; Ken Patrene; Joel S Greenberger
Small molecule GS-nitroxide ameliorates ionizing irradiation-induced delay in bone wound healing in a novel murine model.
In vivo (Athens, Greece) 2010;24(4):377-85.
2010: Michael W Epperly; Darcy Franicola; Donna Shields; Jean-Claude Rwigema; Brandon Stone; Xichen Zhang; William McBride; George Georges; Peter Wipf; Joel S Greenberger
Screening of antimicrobial agents for in vitro radiation protection and mitigation capacity, including those used in supportive care regimens for bone marrow transplant recipients.
In vivo (Athens, Greece) 2010;24(1):9-19.
2010: Michael W Epperly; Stephen Y Lai; Anthony J Kanai; Neal Mason; Brian Lopresi; Tracey Dixon; Darcy Franicola; Yunyun Niu; William Wilson; Joel S Greenberger
Effectiveness of combined modality radiotherapy of orthotopic human squamous cell carcinomas in Nu/Nu mice using cetuximab, tirapazamine and MnSOD-plasmid liposome gene therapy.
In vivo (Athens, Greece) 2010;24(1):1-8.
2009: Jianfei Jiang; Peter R McDonald; Tracy M Dixon; Darcy Franicola; Xichen Zhang; Suhua Nie; Laura D Epperly; Zhentai Huang; Valerian E Kagan; John Lazo; Michael W Epperly; Joel S Greenberger
Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector.
Radiation research 2009;172(4):414-22.
2009: Malolan S Rajagopalan; Kanika Gupta; Michael W Epperly; Darcy Franicola; Xichen Zhang; Hong Wang; Hong Zhao; Vladimir A Tyurin; Joshua G Pierce; Valerian E Kagan; Peter Wipf; Anthony J Kanai; Joel S Greenberger
The mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair.
In vivo (Athens, Greece) 2009;23(5):717-26.
2009: Michael W Epperly; Rebecca Rugo; Shaonan Cao; Hong Wang; Darcy Franicola; Julie P Goff; Hongmei Shen; Xichen Zhang; Dominika Wiktor-Brown; Bevin P Engelward; Joel S Greenberger
Investigation of the effects of aging on homologous recombination in long-term bone marrow cultures.
In vivo (Athens, Greece) 2009;23(5):669-77.
2009: Julie P Goff; Donna S Shields; Mineaki Seki; Serah Choi; Michael W Epperly; Tracy Dixon; Hong Wang; Christopher J Bakkenist; Stephen D Dertinger; Dorothea K Torous; John Wittschieben; Richard D Wood; Joel S Greenberger
Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation.
Radiation research 2009;172(2):165-74.
2009: Michael W Epperly; J A Melendez; Xichen Zhang; Suhua Nie; Linda Pearce; James Peterson; Darcy Franicola; Tracy Dixon; Benjamin A Greenberger; Paavani Komanduri; Hong Wang; Joel S Greenberger
Mitochondrial targeting of a catalase transgene product by plasmid liposomes increases radioresistance in vitro and in vivo.
Radiation research 2009;171(5):588-95.
2009: Linda L Pearce; Sandra Martinez-Bosch; Elisenda Lopez Manzano; Daniel E Winnica; Michael W Epperly; Jim Peterson
The resistance of electron-transport chain Fe-S clusters to oxidative damage during the reaction of peroxynitrite with mitochondrial complex II and rat-heart pericardium.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2009;20(3):135-42.
2009: Joel S Greenberger; Michael W Epperly
Bone marrow-derived stem cells and radiation response.
Seminars in radiation oncology 2009;19(2):133-9.
2009: Yulia Y Tyurina; Vladimir A Tyurin; Valentina I Kapralova; Andrew A Amoscato; Michael W Epperly; Joel S Greenberger; Valerian E Kagan
Mass-spectrometric characterization of phospholipids and their hydroperoxide derivatives in vivo: effects of total body irradiation.
Methods in molecular biology (Clifton, N.J.) 2009;580():153-83.
2008: Takeo Fujita; Michael W Epperly; Hui Zou; Joel S Greenberger; Yong Wan
Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells.
Molecular biology of the cell 2008;19(12):5446-55.
2008: Michael W Epperly; Tracy Dixon; Hong Wang; James Schlesselman; Darcy Franicola; Joel S Greenberger
Modulation of radiation-induced life shortening by systemic intravenous MnSOD-plasmid liposome gene therapy.
Radiation research 2008;170(4):437-43.
2008: Xichen Zhang; Michael W Epperly; Mark A Kay; Zhi-Ying Chen; Tracy Dixon; Darcy Franicola; Benjamin A Greenberger; Paavani Komanduri; Joel S Greenberger
Radioprotection in vitro and in vivo by minicircle plasmid carrying the human manganese superoxide dismutase transgene.
Human gene therapy 2008;19(8):820-6.
2008: Wei Qiu; Eleanor B Carson-Walter; Hongtao Liu; Michael W Epperly; Joel S Greenberger; Gerard P Zambetti; Lin Zhang; Jian Yu
PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome.
Cell stem cell 2008;2(6):576-83.
2008: Shuanhu Zhou; Joel S Greenberger; Michael W Epperly; Julie P Goff; Carolyn Adler; Meryl Leboff; Julie Glowacki
Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts.
Aging cell 2008;7(3):335-43.
2008: Jianfei Jiang; Natalia A Belikova; Adam T Hoye; Qing Zhao; Michael W Epperly; Joel S Greenberger; Peter Wipf; Valerian E Kagan
A mitochondria-targeted nitroxide/hemigramicidin S conjugate protects mouse embryonic cells against gamma irradiation.
International journal of radiation oncology, biology, physics 2008;70(3):816-25.
2008: Y Niu; Michael W Epperly; H Shen; T Smith; H Wang; Joel S Greenberger
Intraesophageal MnSOD-plasmid liposome enhances engraftment and self-renewal of bone marrow derived progenitors of esophageal squamous epithelium.
Gene therapy 2008;15(5):347-56.
2008: Yulia Y Tyurina; Vladimir A Tyurin; Michael W Epperly; Joel S Greenberger; Valerian E Kagan
Oxidative lipidomics of gamma-irradiation-induced intestinal injury.
Free radical biology & medicine 2008;44(3):299-314.
2007: Michael W Epperly; Laura D Epperly; Yunyun Niu; Hong Wang; Xichen Zhang; Darcy Franicola; Joel S Greenberger
Overexpression of the MnSOD transgene product protects cryopreserved bone marrow hematopoietic progenitor cells from ionizing radiation.
Radiation research 2007;168(5):560-6.
2007: Michael W Epperly; Shunqian Jin; Suhua Nie; Shaonan Cao; Xichen Zhang; Darcy Franicola; Hong Wang; Mitchell Fink; Joel S Greenberger
Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation.
Radiation research 2007;168(5):552-9.
2007: Natalia A Belikova; Jianfei Jiang; Yulia Y Tyurina; Qing Zhao; Michael W Epperly; Joel S Greenberger; Valerian E Kagan
Cardiolipin-specific peroxidase reactions of cytochrome C in mitochondria during irradiation-induced apoptosis.
International journal of radiation oncology, biology, physics 2007;69(1):176-86.
2007: Joel S Greenberger; Michael W Epperly
Review. Antioxidant gene therapeutic approaches to normal tissue radioprotection and tumor radiosensitization.
In vivo (Athens, Greece) 2007;21(2):141-6.
2007: Michael W Epperly; Rodney Wegner; Anthony J Kanai; Valerian Kagan; Emily E Greenberger; Suhua Nie; Joel S Greenberger
Effects of MnSOD-plasmid liposome gene therapy on antioxidant levels in irradiated murine oral cavity orthotopic tumors.
Radiation research 2007;167(3):289-97.
2007: Anthony J Kanai; Irina Zabbarova; Andrew A Amoscato; Michael W Epperly; Jingbo Xiao; Peter Wipf
Mitochondrial targeting of radioprotectants using peptidyl conjugates.
Organic & biomolecular chemistry 2007;5(2):307-9.
2007: Michael W Epperly; Shaonan Cao; Xichen Zhang; Darcy Franicola; Hongmei Shen; Emily E Greenberger; Laura D Epperly; Joel S Greenberger
Increased longevity of hematopoiesis in continuous bone marrow cultures derived from NOS1 (nNOS, mtNOS) homozygous recombinant negative mice correlates with radioresistance of hematopoietic and marrow stromal cells.
Experimental hematology 2007;35(1):137-45.
2006: Michael W Epperly; Darcy Franicola; Xichen Zhang; Suhua Nie; Joel S Greenberger
Effect of EGFR antagonists gefitinib (Iressa) and C225 (Cetuximab) on MnSOD-plasmid liposome transgene radiosensitization of a murine squamous cell carcinoma cell line.
In vivo (Athens, Greece) 2006;20(6B):791-6.
2006: Valerian E Kagan; Yulia Y Tyurina; Hülya Bayir; Charleen T Chu; Alexandr A Kapralov; Irina I Vlasova; Natalia A Belikova; Vladimir A Tyurin; Andrew A Amoscato; Michael W Epperly; Joel S Greenberger; Steven T DeKosky; Anna A Shvedova; Jianfei Jiang
The "pro-apoptotic genies" get out of mitochondria: oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes.
Chemico-biological interactions 2006;163(1-2):15-28.
2006: Michael W Epperly; Darcy Franicola; Xichen Zhang; Suhua Nie; Hong Wang; Alfred B Bahnson; Donna S Shields; Julie P Goff; Hongmei Shen; Joel S Greenberger
Reduced irradiation pulmonary fibrosis and stromal cell migration in Smad3-/- marrow chimeric mice.
In vivo (Athens, Greece) 2006;20(5):573-82.
2006: Michael W Epperly; Donna Shields; Yunyun Niu; Timothy M Carlos; Joel S Greenberger
Bone marrow from CD18-/- (MAC-1-/-) homozygous deletion recombinant negative mice demonstrates increased longevity in long-term bone marrow culture and decreased contribution to irradiation pulmonary damage.
In vivo (Athens, Greece) 2006;20(4):431-8.
2006: Michael W Epperly; Julie P Goff; Xichen Zhang; Yunyun Niu; Donna S Shields; Hong Wang; Hongmei Shen; Darcy Franicola; Alfred B Bahnson; Suhua Nie; Emily E Greenberger; Joel S Greenberger
Increased radioresistance, g(2)/m checkpoint inhibition, and impaired migration of bone marrow stromal cell lines derived from Smad3(-/-) mice.
Radiation research 2006;165(6):671-7.
2006: Michael W Epperly; Emily E Greenberger; Darcy Franicola; Samuel Jacobs; Joel S Greenberger
Thalidomide radiosensitization of normal murine hematopoietic but not squamous cell carcinoma or multiple myeloma tumor cell lines.
In vivo (Athens, Greece) 2006;20(3):333-9.
2005: Linda L Pearce; Anthony J Kanai; Michael W Epperly; Jim Peterson
Nitrosative stress results in irreversible inhibition of purified mitochondrial complexes I and III without modification of cofactors.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2005;13(4):254-63.
2005: Michael W Epperly; Yulia Y Tyurina; Suhua Nie; Yun Yun Niu; Xichen Zhang; Valerian Kagan; Joel S Greenberger
MnSOD-plasmid liposome gene therapy decreases ionizing irradiation-induced lipid peroxidation of the esophagus.
In vivo (Athens, Greece) 2005;19(6):997-1004.
2005: Yunyun Niu; Hongmei Shen; Michael W Epperly; Xichen Zhang; Suhua Nie; Shaonan Cao; Joel S Greenberger
Protection of esophageal multi-lineage progenitors of squamous epithelium (stem cells) from ionizing irradiation by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy.
In vivo (Athens, Greece) 2005;19(6):965-74.
2005: M Carpenter; Michael W Epperly; A Agarwal; Suhua Nie; L Hricisak; Y Niu; Joel S Greenberger
Inhalation delivery of manganese superoxide dismutase-plasmid/liposomes protects the murine lung from irradiation damage.
Gene therapy 2005;12(8):685-93.
2005: Michael W Epperly; Shaonan Cao; Julie Goff; Donna Shields; Shuanhu Zhou; Julie Glowacki; Joel S Greenberger
Increased longevity of hematopoiesis in continuous bone marrow cultures and adipocytogenesis in marrow stromal cells derived from Smad3(-/-) mice.
Experimental hematology 2005;33(3):353-62.
2005: Yaron Perry; Michael W Epperly; Hiran C Fernando; Ed Klein; Sid Finkelstein; Joel S Greenberger; James D Luketich
Photodynamic therapy induced esophageal stricture--an animal model: from mouse to pig.
The Journal of surgical research 2005;123(1):67-74.
2004: Michael W Epperly; Hongmei Shen; Mia Jefferson; Joel S Greenberger
In vitro differentiation capacity of esophageal progenitor cells with capacity for homing and repopulation of the ionizing irradiation-damaged esophagus.
In vivo (Athens, Greece) 2004;18(6):675-85.
2004: Sufi Thomas; Qing Zeng; Michael W Epperly; William Gooding; Ira Pastan; Qing-Cheng Wang; Joel S Greenberger; Jennifer Rubin Grandis
Abrogation of head and neck squamous cell carcinoma growth by epidermal growth factor receptor ligand fused to pseudomonas exotoxin transforming growth factor alpha-PE38.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):7079-87.
2004: Michael W Epperly; Hongliang Guo; Hongmei Shen; Yunyun Niu; Xichen Zhang; Mia Jefferson; Christine A Sikora; Joel S Greenberger
Bone marrow origin of cells with capacity for homing and differentiation to esophageal squamous epithelium.
Radiation research 2004;162(3):233-40.
2004: Michael W Epperly; Matthew Carpenter; Anurag Agarwal; Priya Mitra; Suhua Nie; Joel S Greenberger
Intraoral manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis.
In vivo (Athens, Greece) 2004;18(4):401-10.
2004: Michael W Epperly; Anatoly Osipov; Ian Martin; Kazuaki K Kawai; Grigory G Borisenko; Yulia Y Tyurina; Mia Jefferson; Michael Bernarding; Joel S Greenberger; Valerian E Kagan
Ascorbate as a "redox sensor" and protector against irradiation-induced oxidative stress in 32D CL 3 hematopoietic cells and subclones overexpressing human manganese superoxide dismutase.
International journal of radiation oncology, biology, physics 2004;58(3):851-61.
2004: Michael W Epperly; Hongliang Guo; Donna Shields; Xichen Zhang; Joel S Greenberger
Correlation of ionizing irradiation-induced late pulmonary fibrosis with long-term bone marrow culture fibroblast progenitor cell biology in mice homozygous deletion recombinant negative for endothelial cell adhesion molecules.
In vivo (Athens, Greece) 2004;18(1):1-14.
2004: Anthony J Kanai; Michael W Epperly; Linda Pearce; Lori A Birder; Mark L Zeidel; Susan Meyers; Joel S Greenberger; william chesney de groat; gerard apodaca; James Peterson
Differing roles of mitochondrial nitric oxide synthase in cardiomyocytes and urothelial cells.
American journal of physiology. Heart and circulatory physiology 2004;286(1):H13-21.
2003: Michael W Epperly; Joan E Gretton; Christine A Sikora; Mia Jefferson; Michael Bernarding; Suhua Nie; Joel S Greenberger
Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage.
Radiation research 2003;160(5):568-78.
2003: Michael W Epperly; Hongliang Guo; Joan E Gretton; Joel S Greenberger
Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis.
American journal of respiratory cell and molecular biology 2003;29(2):213-24.
2003: Baohong Cao; Bo Zheng; Ron J Jankowski; Shigemi Kimura; Makoto Ikezawa; Bridget M Deasy; James Cummins; Michael W Epperly; Zhuqing Qu-Petersen; Johnny Huard
Muscle stem cells differentiate into haematopoietic lineages but retain myogenic potential.
Nature cell biology 2003;5(7):640-6.
2003: Michael W Epperly; Michael Bernarding; Joan Gretton; Mia Jefferson; Suhua Nie; Joel S Greenberger
Overexpression of the transgene for manganese superoxide dismutase (MnSOD) in 32D cl 3 cells prevents apoptosis induction by TNF-alpha, IL-3 withdrawal, and ionizing radiation.
Experimental hematology 2003;31(6):465-74.
2003: Joel S Greenberger; Michael W Epperly; Joan Gretton; Mia Jefferson; Suhua Nie; Michael Bernarding; Valerian E Kagan; Hong Liang Guo
Radioprotective gene therapy.
Current gene therapy 2003;3(3):183-95.
2003: Hongliang Guo; Jose A Seixas-Silva; Michael W Epperly; Joan E Gretton; Dong M Shin; Dafna Bar-Sagi; Herbert Archer; Joel S Greenberger
Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene.
Radiation research 2003;159(3):361-70.
2003: Hong Liang Guo; Darren Wolfe; Michael W Epperly; Shaohua Huang; Kaihong Liu; Joseph C Glorioso; Joel S Greenberger; David Blumberg
Gene transfer of human manganese superoxide dismutase protects small intestinal villi from radiation injury.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2003;7(2):229-35; discussion 235-6.
2003: Hongliang Guo; Michael W Epperly; Michael Bernarding; Suhua Nie; Joan Gretton; Mia Jefferson; Joel S Greenberger
Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) intratracheal gene therapy reduction of irradiation-induced inflammatory cytokines does not protect orthotopic Lewis lung carcinomas.
In vivo (Athens, Greece) 2003;17(1):13-21.
2003: Michael W Epperly; Hong Liang Guo; Mia Jefferson; Suhua Nie; Joan Gretton; Michael Bernarding; Dafna Bar-Sagi; Herbert Archer; Joel S Greenberger
Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase-plasmid/liposomes (MnSOD-PL) during lung radioprotective gene therapy.
Gene therapy 2003;10(2):163-71.
2002: Anthony J Kanai; Mark L Zeidel; John Lavelle; Joel S Greenberger; Lori A Birder; william chesney de groat; gerard apodaca; Susan A Meyers; Richard Ramage; Michael W Epperly
Manganese superoxide dismutase gene therapy protects against irradiation-induced cystitis.
American journal of physiology. Renal physiology 2002;283(6):F1304-12.
2002: Michael W Epperly; Christine A Sikora; Stacy J Defilippi; Joan Gretton; Qimin Zhan; Donald Kufe; Joel S Greenberger
Manganese superoxide dismutase (SOD2) inhibits radiation-induced apoptosis by stabilization of the mitochondrial membrane.
Radiation research 2002;157(5):568-77.
2002: Michael W Epperly; Stacy J Defilippi; Christine A Sikora; Joan Gretton; Joel S Greenberger
Radioprotection of lung and esophagus by overexpression of the human manganese superoxide dismutase transgene.
Military medicine 2002;167(2 Suppl):71-3.
2002: Michael W Epperly; Christine A Sikora; Stacy J Defilippi; Joan E Gretton; Dafna Bar-Sagi; Herbert Archer; Timothy M Carlos; HongLiang Guo; Joel S Greenberger
Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2002;8(4):175-87.
2001: Michael W Epperly; Valerian E Kagan; Christine A Sikora; Joan E Gretton; Stacy J Defilippi; Dafna Bar-Sagi; Joel S Greenberger
Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation.
International journal of cancer. Journal international du cancer 2001;96(4):221-31.
2001: Joel S Greenberger; Valerian E Kagan; L Pearce; G Boriseniao; Yulia Y Tyurina; Michael W Epperly
Modulation of redox signal transduction pathways in the treatment of cancer.
Antioxidants & redox signaling 2001;3(3):347-59.
2001: Linda L Pearce; Michael W Epperly; Joel S Greenberger; Bruce R Pitt; Jim Peterson
Identification of respiratory complexes I and III as mitochondrial sites of damage following exposure to ionizing radiation and nitric oxide.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2001;5(2):128-36.
2001: Michael W Epperly; Elizabeth L Travis; J A Whitsett; Ines Raineri; C J Epstein; Joel S Greenberger
Overexpression of manganese superoxide dismutase (MnSOD) in whole lung or alveolar type II cells of MnSOD transgenic mice does not provide intrinsic lung irradiation protection.
International journal of cancer. Journal international du cancer 2001;96(1):11-21.
2001: Michael W Epperly; Joan Gretton; Stacy J Defilippi; Joel S Greenberger; Christine A Sikora; D Liggitt; G Koe
Modulation of radiation-induced cytokine elevation associated with esophagitis and esophageal stricture by manganese superoxide dismutase-plasmid/liposome (SOD2-PL) gene therapy.
Radiation research 2001;155(1 Pt 1):2-14.
2000: Michael W Epperly; C J Epstein; Elizabeth L Travis; Joel S Greenberger
Decreased pulmonary radiation resistance of manganese superoxide dismutase (MnSOD)-deficient mice is corrected by human manganese superoxide dismutase-Plasmid/Liposome (SOD2-PL) intratracheal gene therapy.
Radiation research 2000;154(4):365-74.
2000: Nikolai V Gorbunov; Kay L Pogue-Geile; Michael W Epperly; William L Bigbee; Romesh A Draviam; Billy W Day; niel wald; simon simon watkins; Joel S Greenberger
Activation of the nitric oxide synthase 2 pathway in the response of bone marrow stromal cells to high doses of ionizing radiation.
Radiation research 2000;154(1):73-86.
2000: Michael W Epperly; Christine A Sikora; Stacy J Defilippi; J Bray; G Koe; D Liggitt; James D Luketich; Joel S Greenberger
Plasmid/liposome transfer of the human manganese superoxide dismutase transgene prevents ionizing irradiation-induced apoptosis in human esophagus organ explant culture.
International journal of cancer. Journal international du cancer 2000;90(3):128-37.
2000: Michael W Epperly; Stacy J Defilippi; Christine A Sikora; Joan Gretton; AM Kalend; Joel S Greenberger
Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation.
Gene therapy 2000;7(12):1011-8.
2000: Joel S Greenberger; Michael W Epperly; James D Luketich; W Gooding; Chandra P Belani
Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy protection of the esophagus from chemoradiotherapy damage during treatment of locally unresectable non-small-cell lung cancer (NSCLC).
Clinical lung cancer 2000;1(4):302-4.
1999: Michael W Epperly; JA Bray; Timothy M Carlos; E Prochownik; Joel S Greenberger
Biology of marrow stromal cell lines derived from long-term bone marrow cultures of Trp53-deficient mice.
Radiation research 1999;152(1):29-40.
1999: Michael W Epperly; JA Bray; P Esocobar; William L Bigbee; S Watkins; Joel S Greenberger
Overexpression of the human manganese superoxide dismutase (MnSOD) transgene in subclones of murine hematopoietic progenitor cell line 32D cl 3 decreases irradiation-induced apoptosis but does not alter G2/M or G1/S phase cell cycle arrest.
Radiation oncology investigations 1999;7(6):331-42.
1999: R L Stickle; Michael W Epperly; E Klein; JA Bray; Joel S Greenberger
Prevention of irradiation-induced esophagitis by plasmid/liposome delivery of the human manganese superoxide dismutase transgene.
Radiation oncology investigations 1999;7(4):204-17.
1999: Michael W Epperly; Elizabeth L Travis; Christine A Sikora; Joel S Greenberger
Manganese [correction of Magnesium] superoxide dismutase (MnSOD) plasmid/liposome pulmonary radioprotective gene therapy: modulation of irradiation-induced mRNA for IL-I, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/fibrosis.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 1999;5(4):204-14.
1999: Michael W Epperly; JA Bray; S Krager; L M Berry; W Gooding; J F Engelhardt; Ralf Michael Zwacka; Elizabeth L Travis; Joel S Greenberger
Intratracheal injection of adenovirus containing the human MnSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis.
International journal of radiation oncology, biology, physics 1999;43(1):169-81.
1998: Kristin Goltry; Michael W Epperly; Joel S Greenberger
Induction of serum amyloid A inflammatory response genes in irradiated bone marrow cells.
Radiation research 1998;149(6):570-8.
1998: Michael W Epperly; J Bray; S Kraeger; Ralf Michael Zwacka; J Engelhardt; Elizabeth L Travis; Joel S Greenberger
Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy.
Gene therapy 1998;5(2):196-208.
1998: SS Floyd; Paula R Clemens; M R Ontell; Stefan Kochanek; Charles S Day; J Yang; S D Hauschka; L Balkir; J Morgan; Morey S Moreland; G W Feero; Michael W Epperly; Johnny Huard
Ex vivo gene transfer using adenovirus-mediated full-length dystrophin delivery to dystrophic muscles.
Gene therapy 1998;5(1):19-30.
1998: Joel S Greenberger; Sanjeev Bahri; J Jett; Chandra P Belani; AM Kalend; Michael W Epperly
Considerations in optimizing radiation therapy for non-small cell lung cancer.
Chest 1998;113(1 Suppl):46S-52S.
1997: M L Balk; J Bray; C Day; Michael W Epperly; Joel S Greenberger; Christopher H Evans; Christopher Niyibizi
Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim).
Bone 1997;21(1):7-15.
1997: William G. Feero; J David Rosenblatt; Johnny Huard; simon simon watkins; Michael W Epperly; Paula R Clemens; Stefan Kochanek; Joseph C Glorioso; Terence A Partridge; Eric Hoffman
Viral gene delivery to skeletal muscle: insights on maturation-dependent loss of fiber infectivity for adenovirus and herpes simplex type 1 viral vectors.
Human gene therapy 1997;8(4):371-80.
1996: Joel S Greenberger; J Anderson; L A Berry; Michael W Epperly; E P Cronkite; SS Boggs
Effects of irradiation of CBA/CA mice on hematopoietic stem cells and stromal cells in long-term bone marrow cultures.
Leukemia 1996;10(3):514-27.
1996: C A Znati; M Rosenstein; Yves Boucher; Michael W Epperly; William D Bloomer; Rakesh K Jain
Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft.
Cancer research 1996;56(5):964-68.
1996: Joel S Greenberger; Michael W Epperly; A Zeevi; KW Brunson; Kristin Goltry; K L Pogue-Geile; J Bray; L Berry
Stromal cell involvement in leukemogenesis and carcinogenesis.
In vivo (Athens, Greece) 1996;10(1):1-17.
1996: Joel S Greenberger; Michael W Epperly; Nadia Jahroudi; K L Pogue-Geile; L Berry; J Bray; Kristin Goltry
Role of bone marrow stromal cells in irradiation leukemogenesis.
Acta haematologica 1996;96(1):1-15.
1995: Michael W Epperly; L Berry; A Halloran; Joel S Greenberger
Inhibition of G1-phase arrest induced by ionizing radiation in hematopoietic cells by overexpression of genes involved in the G1/S-phase transition.
Radiation research 1995;143(3):245-54.
1995: AM Kalend; William D Bloomer; Michael W Epperly
Dosimetric consequences of 10B(n, alpha)7Li reaction occurring at the cellular membrane.
International journal of radiation oncology, biology, physics 1995;31(1):171-8.
1994: Howard Rosenzweig; G N Ranadive; T Seskey; Michael W Epperly; William D Bloomer
A novel method for the non-chromatographic purification of technetium-99m-labeled monoclonal antibodies: a study with B72.3 monoclonal antibody.
Nuclear medicine and biology 1994;21(2):171-8.
1993: A M Koros; M J Tobin; Michael W Epperly; G Levine; J R McGinley
186Rhenium-HNK1 monoclonal antibody targets human small cell lung cancer cells in athymic nude mice: rapid screening model for therapy.
Anticancer research 1993;13(6A):1953-6.
1993: G N Ranadive; Howard Rosenzweig; Michael W Epperly; T Seskey; William D Bloomer
A new method of technetium-99m labeling of monoclonal antibodies through sugar residues. A study with TAG-72 specific CC-49 antibody.
Nuclear medicine and biology 1993;20(6):719-26.
1993: G N Ranadive; Howard Rosenzweig; Michael W Epperly; William D Bloomer
A technique to prepare boronated B72.3 monoclonal antibody for boron neutron capture therapy.
Nuclear medicine and biology 1993;20(1):1-6.
1992: Maria V Papadopoulou; Michael W Epperly; D S Shields; William D Bloomer
Radiosensitization and hypoxic cell toxicity of NLA-1 and NLA-2, two new bioreductive compounds.
Japanese journal of cancer research : Gann 1992;83(4):410-4.
1992: J A Prezioso; Michael W Epperly; N Wang; William D Bloomer
Effects of tyrosinase activity on the cytotoxicity of 4-S-cysteaminylphenol and N-acetyl-4-S-cysteaminylphenol in melanoma cells.
Cancer letters 1992;63(1):73-9.
1991: Michael W Epperly; K M Damodaran; W H McLaughlin; K M Pillai; William D Bloomer
Radiotoxicity of 17 alpha-[125I]iodovinyl-11 beta-methoxyestradiol in MCF-7 human breast cancer cells.
The Journal of steroid biochemistry and molecular biology 1991;39(5A):729-34.
1989: W H McLaughlin; Michael W Epperly; William D Bloomer
Correspondence re: Yasuyuki Sugiyama et al., Selective growth inhibition of human lung cancer cell lines bearing a surface glycoprotein gp160 by 125I-labeled anti-gp160 monoclonal antibody.
Cancer research 1989;49(20):5774-5.