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Hediye Erdjument-Bromage

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Yu-Ting Su; Paul Tempst; Anthony Wang; Benlian Wang; Hediye Erdjument-Bromage; Chengzhuo Gao; Shuang Guo; Yu Liu; Masaru Miyagi; Hung-Ying Kao
Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7.
William W Lockwood; Greg L Stewart; Sahiba K Chandel; Hediye Erdjument-Bromage; Levi J Beverly
The Novel Ubiquitin Ligase Complex, SCF(Fbxw4), Interacts with the COP9 Signalosome in an F-Box Dependent Manner, Is Mutated, Lost and Under-Expressed in Human Cancers.
Thomas L Nickolas; Meghan E Sise; Paul Tempst; David Solá-Del Valle; Melanie Viltard; Landino Allegri; Lucia Argentiero; Nicholas Barasch; Michael Bennett; Achiropita Bovino; Charles Buchen; Maria Luisa Carnevali; Prasad Devarajan; Hediye Erdjument-Bromage; Catherine S Forster; Shlomo Kupferman; Andrea Magnano; Silvia Mattei; Kiyoshi Mori; Jonathan Barasch
NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease.

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2013: Yu-Ting Su; Paul Tempst; Anthony Wang; Benlian Wang; Hediye Erdjument-Bromage; Chengzhuo Gao; Shuang Guo; Yu Liu; Masaru Miyagi; Hung-Ying Kao
Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7.
Molecular and cellular biology 2013;33(8):1546-60.
2013: William W Lockwood; Greg L Stewart; Sahiba K Chandel; Hediye Erdjument-Bromage; Levi J Beverly
The Novel Ubiquitin Ligase Complex, SCF(Fbxw4), Interacts with the COP9 Signalosome in an F-Box Dependent Manner, Is Mutated, Lost and Under-Expressed in Human Cancers.
PloS one 2013;8(5):e63610.
2012: Thomas L Nickolas; Meghan E Sise; Paul Tempst; David Solá-Del Valle; Melanie Viltard; Landino Allegri; Lucia Argentiero; Nicholas Barasch; Michael Bennett; Achiropita Bovino; Charles Buchen; Maria Luisa Carnevali; Prasad Devarajan; Hediye Erdjument-Bromage; Catherine S Forster; Shlomo Kupferman; Andrea Magnano; Silvia Mattei; Kiyoshi Mori; Jonathan Barasch
NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease.
Kidney international 2012;82(6):718-22.
2012: Shruti Malu; Jesse Pena; Paul Tempst; Paolo Vezzoni; Anna Villa; Noritaka Adachi; Aneel K Aggarwal; Pablo De Ioannes; Hediye Erdjument-Bromage; Carlos R Escalante; Dailia Francis; Marsha Greene; Mary Hanna; Mikhail Kozlov; Aya Kurosawa; Patricia Cortes
Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs.
The Journal of experimental medicine 2012;209(5):955-63.
2012: Ali A Abdul-Sater; Serge L Beaucage; Hediye Erdjument-Bromage; Andrzej Grajkowski; Carolyn Lee; Assaf Levi; Courtney Plumlee; Michael T Schreiber; Howard Shuman; Christian Schindler
The overlapping host responses to bacterial cyclic dinucleotides.
Microbes and infection / Institut Pasteur 2012;14(2):188-97.
2012: Benedetta Ruzzenente; James B Stewart; Paul Tempst; Rolf Wibom; Anna Wredenberg; Volker Zickermann; Ulrich Brandt; Ana Bratic; Yolanda Cámara; Hediye Erdjument-Bromage; Claes M Gustafsson; Kjell Hultenby; Metodi D Metodiev; Dusanka Milenkovic; Chan Bae Park; Nils-Göran Larsson
LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs.
The EMBO journal 2012;31(2):443-56.
2012: Levi J Beverly; Hediye Erdjument-Bromage; William W Lockwood; Parag P Shah; Harold Varmus
Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(3):E119-26.
2011: Kamalika Moulick; Len Neckers; Stephen D Nimer; Fabiana Perna; Nagavarakishore Pillarsetty; Anna Rodina; Peter Smith-Jones; Tony Taldone; Ly P Vu; Danuta Zatorska; Xinyang Zhao; Hongliang Zong; Hediye Erdjument-Bromage; Erica M Gomes DaGama; Steven S Gross; Monica L Guzman; Katerina Hatzi; Thomas Ku; Steven M Larson; Ross Levine; Jason S Lewis; Ari Melnick; James H Ahn; Mary Alpaugh; Kristin Beebe; Eloisi Caldas Lopes; Leandro Cerchietti; Gabriela Chiosis
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.
Nature chemical biology 2011;7(11):818-26.
2011: Romel Somwar; Paul J Tempst; Guangli Yang; Hakim Djaballah; Hediye Erdjument-Bromage; Erik Larsson; William W Lockwood; Ouathek Ouerfelli; Chris Sander; David Shum; Harold E Varmus
Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(39):16375-80.
2011: Jonathan Cooper; Hediye Erdjument-Bromage; Marco Giovannini; C Oliver Hanemann; Ryohei Ishii; Wei Li; Stephen Barstow Long; Angela Pepe-Caprio; Gaia Schiavon; Paul Tempst; Liru You; Lu Zhou; Pengbo Zhou; Filippo G Giancotti
Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression.
Science signaling 2011;4(188):pt6.
2011: Beate Schwer; Hediye Erdjument-Bromage; Stewart Shuman
Composition of yeast snRNPs and snoRNPs in the absence of trimethylguanosine caps reveals nuclear cap binding protein as a gained U1 component implicated in the cold-sensitivity of tgs1Δ cells.
Nucleic acids research 2011;39(15):6715-28.
2011: Sookil Tae; Paul Tempst; Kevin Velasco; Mariana Yaneva; Hediye Erdjument-Bromage; Vrajesh Karkhanis; Saïd Sif
Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes.
Nucleic acids research 2011;39(13):5424-38.
2011: Patrick Trojer; Alina R Cao; Zhonghua Gao; Yan Li; Jin Zhang; Xiaoqin Xu; Guohong Li; Regine Losson; Hediye Erdjument-Bromage; Paul Tempst; Peggy J Farnham; Danny Reinberg
L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure.
Molecular cell 2011;42(4):438-50.
2011: Yolanda Cámara; Jorge Asin-Cayuela; Chan Bae Park; Metodi D Metodiev; Yonghong Shi; Benedetta Ruzzenente; Christian Kukat; Bianca Habermann; Rolf Wibom; Kjell Hultenby; Thomas Franz; Hediye Erdjument-Bromage; Paul Tempst; B Martin Hallberg; Claes M Gustafsson; Nils-Göran Larsson
MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome.
Cell metabolism 2011;13(5):527-39.
2011: A Phillip West; Igor E Brodsky; Christoph Rahner; Dong Kyun Woo; Hediye Erdjument-Bromage; Paul Tempst; Matthew C Walsh; Yongwon Choi; Gerald S Shadel; Sankar Ghosh
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.
Nature 2011;472(7344):476-80.
2011: Nikhil Singla; Hediye Erdjument-Bromage; Juha P Himanen; Tom W Muir; Dimitar B Nikolov
A semisynthetic Eph receptor tyrosine kinase provides insight into ligand-induced kinase activation.
Chemistry & biology 2011;18(3):361-71.
2011: Jennifer A Young; Decha Sermwittayawong; Hee-Jung Kim; Suruchi Nandu; Namsil An; Hediye Erdjument-Bromage; Paul Tempst; Laurent Coscoy; Astar Winoto
Fas-associated death domain (FADD) and the E3 ubiquitin-protein ligase TRIM21 interact to negatively regulate virus-induced interferon production.
The Journal of biological chemistry 2011;286(8):6521-31.
2011: Zhuo Zhang; Li-Chen Wu; Wei Yang; Chia-Wei Chang; Qian Dai; Hediye Erdjument-Bromage; Yahong Guo; Amanda Jones; Heui-Yun Joo; Youngsook Lee; Chao Li; Kaimao Liu; Jinrong Min; Matthew R Mysliwiec; Kevin M Pawlik; Chiao-Wang Sun; Paul Tempst; Tim M Townes; Hengbin Wang
PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming.
Stem cells (Dayton, Ohio) 2011;29(2):229-40.
2010: Wei Li; Liru You; Jonathan Cooper; Gaia Schiavon; Angela Pepe-Caprio; Lu Zhou; Ryohei Ishii; Marco Giovannini; C Oliver Hanemann; Stephen Barstow Long; Hediye Erdjument-Bromage; Pengbo Zhou; Paul Tempst; Filippo G Giancotti
Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.
Cell 2010;140(4):477-90.
2010: Dawei Gou; Monica Rubalcava; Silvia Sauer; Felipe Mora-Bermúdez; Hediye Erdjument-Bromage; Paul Tempst; Elisabeth Kremmer; Frank Sauer
SETDB1 is involved in postembryonic DNA methylation and gene silencing in Drosophila.
PloS one 2010;5(5):e10581.
2010: Zhonghua Gao; Noor Gammoh; Pui-Mun Wong; Hediye Erdjument-Bromage; Paul Tempst; Xuejun Jiang
Processing of autophagic protein LC3 by the 20S proteasome.
Autophagy 2010;6(1):126-37.
2009: Sheng Gao; Claudio Alarcón; Gopal Sapkota; Sadia Rahman; Pan-Yu Chen; Nina Goerner; Maria J Macias; Hediye Erdjument-Bromage; Paul Tempst; Joan Massagué
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling.
Molecular cell 2009;36(3):457-68.
2009: Wen Yuan; Jingwei Xie; Chengzu Long; Hediye Erdjument-Bromage; Xiaojun Ding; Yong Zheng; Paul Tempst; She Chen; Bing Zhu; Danny Reinberg
Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo.
The Journal of biological chemistry 2009;284(23):15701-7.
2009: Benjamin M Dale; Daniel Traum; Hediye Erdjument-Bromage; Paul Tempst; Steven Greenberg
Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(9):5654-62.
2009: Mina Pellegrini; Jorge Asin-Cayuela; Hediye Erdjument-Bromage; Paul Tempst; Nils-Goran Larsson; Claes M Gustafsson
MTERF2 is a nucleoid component in mammalian mitochondria.
Biochimica et biophysica acta 2009;1787(5):296-302.
2009: Hui-Kuan Lin; Guocan Wang; Zhenbang Chen; Julie T Feldstein; Yan Liu; Chia-Hsin Chan; Wei-Lei Yang; Hediye Erdjument-Bromage; Keiichi I Nakayama; Stephen D Nimer; Paul Tempst; Pier Paolo Pandolfi
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.
Nature cell biology 2009;11(4):420-32.
2009: Nara Lee; Hediye Erdjument-Bromage; Paul Tempst; Richard S Jones; Yi Zhang
The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3.
Molecular and cellular biology 2009;29(6):1401-10.
2009: Andrew Xiao; Haitao Li; David Shechter; Sung Hee Ahn; Laura A Fabrizio; Hediye Erdjument-Bromage; Satoko Ishibe-Murakami; Bin Wang; Paul Tempst; Kay Hofmann; Dinshaw J Patel; Stephen J Elledge; C David Allis
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.
Nature 2009;457(7225):57-62.
2008: Marianna Tcherpakov; Limor Broday; Agnes Delaunay; Takayuki Kadoya; Ashwani Khurana; Hediye Erdjument-Bromage; Paul Tempst; Xiao-Bo Qiu; George N DeMartino; Ze'ev Ronai
JAMP optimizes ERAD to protect cells from unfolded proteins.
Molecular biology of the cell 2008;19(11):5019-28.
2008: Patrick Seale; Bryan Bjork; Wenli Yang; Shingo Kajimura; Sherry Chin; Shihuan Kuang; Anthony Scimè; Srikripa Devarakonda; Heather M Conroe; Hediye Erdjument-Bromage; Paul Tempst; Michael A Rudnicki; David Beier; Bruce M Spiegelman
PRDM16 controls a brown fat/skeletal muscle switch.
Nature 2008;454(7207):961-7.
2008: R B Parmigiani; Wei-Sheng Xu; G Venta-Perez; Hediye Erdjument-Bromage; Mariana Yaneva; Paul Tempst; Paul A Marks
HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9633-8.
2008: Soundarapandian Vijayakumar; Hediye Erdjument-Bromage; Paul Tempst; Qais Al-Awqati
Role of integrins in the assembly and function of hensin in intercalated cells.
Journal of the American Society of Nephrology : JASN 2008;19(6):1079-91.
2008: Kristian Kvint; Jay P Uhler; Michael J Taschner; Stefan Sigurdsson; Hediye Erdjument-Bromage; Paul Tempst; Jesper Q Svejstrup
Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease Ubp3.
Molecular cell 2008;30(4):498-506.
2008: Shingo Kajimura; Patrick Seale; Takuya Tomaru; Hediye Erdjument-Bromage; Marcus P Cooper; Jorge Ruas; Sherry Chin; Paul Tempst; Mitchell Lazar; Bruce M Spiegelman
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
Genes & development 2008;22(10):1397-409.
2008: Heather Szerlong; Kaede Hinata; Ramya Viswanathan; Hediye Erdjument-Bromage; Paul Tempst; Bradley R Cairns
The HSA domain binds nuclear actin-related proteins to regulate chromatin-remodeling ATPases.
Nature structural & molecular biology 2008;15(5):469-76.
2008: xinyang zhao; Vlaidmir Jankovic; Alexander Gural; Gang Huang; Animesh Pardanani; Silvia Menendez; J Zhang; Richard Dunne; Andrew Xiao; Hediye Erdjument-Bromage; C David Allis; Paul Tempst; Stephen D Nimer
Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity.
Genes & development 2008;22(5):640-53.
2008: Ru Cao; Hengbin Wang; Jin He; Hediye Erdjument-Bromage; Paul Tempst; Yi Zhang
Role of hPHF1 in H3K27 methylation and Hox gene silencing.
Molecular and cellular biology 2008;28(5):1862-72.
2007: Robert J Sims; Scott Millhouse; Chi-Fu Chen; Brian A Lewis; Hediye Erdjument-Bromage; Paul Tempst; James L Manley; Danny Reinberg
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing.
Molecular cell 2007;28(4):665-76.
2007: Alejandro Vaquero; Michael Scher; Hediye Erdjument-Bromage; Paul Tempst; Lourdes Serrano; Danny Reinberg
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.
Nature 2007;450(7168):440-4.
2007: Heui-Yun Joo; Ling Zhai; Chunying Yang; Shuyi Nie; Hediye Erdjument-Bromage; Paul Tempst; Chenbei Chang; Hengbin Wang
Regulation of cell cycle progression and gene expression by H2A deubiquitination.
Nature 2007;449(7165):1068-72.
2007: Pascal N Bernatchez; Lisette Acevedo; Carlos Fernandez-Hernando; Takahisa Murata; Cécile Chalouni; Jiae Kim; Hediye Erdjument-Bromage; Vijay Shah; Jean-Philippe Gratton; Elizabeth McNally; Paul Tempst; William C Sessa
Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function.
The Journal of biological chemistry 2007;282(42):30745-53.
2007: Ping Zhu; Wenlai Zhou; Jianxun Wang; Janusz Puc; Kenneth A Ohgi; Hediye Erdjument-Bromage; Paul Tempst; Christopher K Glass; Michael G Rosenfeld
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation.
Molecular cell 2007;27(4):609-21.
2007: Steen K T Ooi; Chen Qiu; Emily Bernstein; Keqin Li; Da Jia; Zhe Yang; Hediye Erdjument-Bromage; Paul Tempst; Shau-Ping Lin; C David Allis; Xiaodong Cheng; Timothy H Bestor
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.
Nature 2007;448(7154):714-7.
2007: Chan Bae Park; Jorge Asin-Cayuela; Yolanda Cámara; Yonghong Shi; Mina Pellegrini; Martina Gaspari; Rolf Wibom; Kjell Hultenby; Hediye Erdjument-Bromage; Paul Tempst; Maria Falkenberg; Claes M Gustafsson; Nils-Göran Larsson
MTERF3 is a negative regulator of mammalian mtDNA transcription.
Cell 2007;130(2):273-85.
2007: Patrick Trojer; Guohong Li; Robert J Sims; Alejandro Vaquero; Nagesh Kalakonda; Piernicola Boccuni; Donghoon Lee; Hediye Erdjument-Bromage; Paul Tempst; Stephen D Nimer; Yuh-Hwa Wang; Danny Reinberg
L3MBTL1, a histone-methylation-dependent chromatin lock.
Cell 2007;129(5):915-28.
2007: Matthew Gordon; Derick G Holt; Anil Panigrahi; Brian T Wilhelm; Hediye Erdjument-Bromage; Paul Tempst; Jürg Bähler; Bradley R Cairns
Genome-wide dynamics of SAPHIRE, an essential complex for gene activation and chromatin boundaries.
Molecular and cellular biology 2007;27(11):4058-69.
2007: Robert J Klose; Kathryn E Gardner; Gaoyang Liang; Hediye Erdjument-Bromage; Paul Tempst; Yi Zhang
Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae?
Molecular and cellular biology 2007;27(11):3951-61.
2007: Baggavalli P Somesh; Stefan Sigurdsson; Hideaki Saeki; Hediye Erdjument-Bromage; Paul Tempst; Jesper Q Svejstrup
Communication between distant sites in RNA polymerase II through ubiquitylation factors and the polymerase CTD.
Cell 2007;129(1):57-68.
2007: Jason Tanny; Hediye Erdjument-Bromage; Paul Tempst; C David Allis
Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation.
Genes & development 2007;21(7):835-47.
2007: Nara Lee; Junyu Zhang; Robert J Klose; Hediye Erdjument-Bromage; Paul Tempst; Richard S Jones; Yi Zhang
The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase.
Nature structural & molecular biology 2007;14(4):341-3.
2007: M Jeyakumar; Xue-feng Liu; Hediye Erdjument-Bromage; Paul Tempst; Milan K Bagchi
Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity.
The Journal of biological chemistry 2007;282(13):9312-22.
2007: Kenichi Yamane; Keisuke Tateishi; Robert J Klose; Jia Fang; Laura A Fabrizio; Hediye Erdjument-Bromage; Joyce Taylor-Papadimitriou; Paul Tempst; Yi Zhang
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation.
Molecular cell 2007;25(6):801-12.
2007: Robert J Klose; Qin Yan; Zuzana Tothova; Kenichi Yamane; Hediye Erdjument-Bromage; Paul Tempst; D Gary Gilliland; Yi Zhang; William G Kaelin
The retinoblastoma binding protein RBP2 is an H3K4 demethylase.
Cell 2007;128(5):889-900.
2007: Lloyd C Trotman; Xinjiang Wang; Andrea Alimonti; Zhenbang Chen; Julie T Feldstein; Haijuan Yang; Nikola P Pavletich; Brett S Carver; Carlos Cordon-Cardo; Hediye Erdjument-Bromage; Paul Tempst; Sung-Gil Chi; Hyo Jong Kim; Tom Misteli; Xuejun Jiang; Pier Paolo Pandolfi
Ubiquitination regulates PTEN nuclear import and tumor suppression.
Cell 2007;128(1):141-56.
2007: Xinjiang Wang; Lloyd C Trotman; Theresa Koppie; Andrea Alimonti; Zhenbang Chen; Zhonghua Gao; Junru Wang; Hediye Erdjument-Bromage; Paul Tempst; Carlos Cordon-Cardo; Pier Paolo Pandolfi; Xuejun Jiang
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.
Cell 2007;128(1):129-39.
2006: Marcus P Cooper; Lishu Qu; Lindsay M Rohas; Jiandie Lin; Wenli Yang; Hediye Erdjument-Bromage; Paul Tempst; Bruce M Spiegelman
Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex.
Genes & development 2006;20(21):2996-3009.
2006: Alina Patke; Ingrid Mecklenbräuker; Hediye Erdjument-Bromage; Paul Tempst; Alexander Tarakhovsky
BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism.
The Journal of experimental medicine 2006;203(11):2551-62.
2006: Shwu-Yuan Wu; A-Young Lee; Samuel Y Hou; Jongsook Kim Kemper; Hediye Erdjument-Bromage; Paul Tempst; Cheng-Ming Chiang
Brd4 links chromatin targeting to HPV transcriptional silencing.
Genes & development 2006;20(17):2383-96.
2006: William A Barton; Dorothea Tzvetkova-Robev; Hediye Erdjument-Bromage; Paul Tempst; Dimitar B Nikolov
Highly efficient selenomethionine labeling of recombinant proteins produced in mammalian cells.
Protein science : a publication of the Protein Society 2006;15(8):2008-13.
2006: Pier Paolo Scaglioni; Thomas M Yung; Lu Fan Cai; Hediye Erdjument-Bromage; Andrew J Kaufman; Bhuvanesh Singh; Julie T Feldstein; Paul Tempst; Pier Paolo Pandolfi
A CK2-dependent mechanism for degradation of the PML tumor suppressor.
Cell 2006;126(2):269-83.
2006: Robert J Klose; Kenichi Yamane; Yangjin Bae; Dianzheng Zhang; Hediye Erdjument-Bromage; Paul Tempst; Jiemin Wong; Yi Zhang
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.
Nature 2006;442(7100):312-6.
2006: Vlad C Seitan; Peter Banks; Steven H Laval; Nazia A Majid; Dale Dorsett; Amer Rana; Jim Smith; Alex Bateman; Sanja Krpic; Arnd Hostert; Robert A Rollins; Hediye Erdjument-Bromage; Paul Tempst; Claire Y Benard; Siegfried Hekimi; Sarah F Newbury; Tom Strachan
Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance.
PLoS biology 2006;4(8):e242.
2006: Wei He; David C Dorn; Hediye Erdjument-Bromage; Paul Tempst; Malcolm A S Moore; Joan Massagué
Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.
Cell 2006;125(5):929-41.
2006: Mariana Yaneva; Serena Kippenberger; Nan Wang; Qin Su; Margaret McGarvey; Arpi Nazarian; Lynne Lacomis; Hediye Erdjument-Bromage; Paul Tempst
PU.1 and a TTTAAA element in the myeloid defensin-1 promoter create an operational TATA box that can impose cell specificity onto TFIID function.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):6906-17.
2006: Hengbin Wang; Ling Zhai; Jun Xu; Heui-Yun Joo; Sarah Jackson; Hediye Erdjument-Bromage; Paul Tempst; Yue Xiong; Yi Zhang
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.
Molecular cell 2006;22(3):383-94.
2006: Kenichi Yamane; Charalambos Toumazou; Yu-ichi Tsukada; Hediye Erdjument-Bromage; Paul Tempst; Jiemin Wong; Yi Zhang
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor.
Cell 2006;125(3):483-95.
2006: Jae-Hyuck Shim; Changchun Xiao; Matthew Hayden; Ki-Young Lee; Eduardo S. Trombetta; Marc Pypaert; Atsuki Nara; Tamotsu Yoshimori; Bettina Wilm; Hediye Erdjument-Bromage; Paul Tempst; Brigid L M Hogan; Ira Mellman; Sankar Ghosh
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.
The Journal of cell biology 2006;172(7):1045-56.
2006: Yu-ichi Tsukada; Jia Fang; Hediye Erdjument-Bromage; Maria E Warren; Christoph H Borchers; Paul Tempst; Yi Zhang
Histone demethylation by a family of JmjC domain-containing proteins.
Nature 2006;439(7078):811-6.
2006: Boris Wilson; Hediye Erdjument-Bromage; Paul Tempst; Bradley R Cairns
The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles.
Genetics 2006;172(2):795-809.
2006: Josep Villanueva; David R Shaffer; John Philip; Carlos A Chaparro; Hediye Erdjument-Bromage; Adam B Olshen; Martin Fleisher; Hans Lilja; Edi Brogi; Jeff Boyd; Marta Sanchez-Carbayo; Eric C Holland; Carlos Cordon-Cardo; Howard I Scher; Paul Tempst
Differential exoprotease activities confer tumor-specific serum peptidome patterns.
The Journal of clinical investigation 2006;116(1):271-84.
2005: Bing Zhu; Yong Zheng; Anh-Dung Pham; Subhrangsu S Mandal; Hediye Erdjument-Bromage; Paul Tempst; Danny Reinberg
Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.
Molecular cell 2005;20(4):601-11.
2005: Ami S Bhatt; Hediye Erdjument-Bromage; Paul Tempst; Charles S Craik; Mark M Moasser
Adhesion signaling by a novel mitotic substrate of src kinases.
Oncogene 2005;24(34):5333-43.
2005: Kelly L West; Netai C Singha; Pablo De Ioannes; Lynne Lacomis; Hediye Erdjument-Bromage; Paul Tempst; Patricia Cortes
A direct interaction between the RAG2 C terminus and the core histones is required for efficient V(D)J recombination.
Immunity 2005;23(2):203-12.
2005: Jing Tian; Ruslana Bryk; Shuangping Shi; Hediye Erdjument-Bromage; Paul Tempst; Carl Nathan
Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes.
Molecular microbiology 2005;57(3):859-68.
2005: Bing Zhu; Subhrangsu S Mandal; Anh-Dung Pham; Yong Zheng; Hediye Erdjument-Bromage; Surinder Batra; Paul Tempst; Danny Reinberg
The human PAF complex coordinates transcription with events downstream of RNA synthesis.
Genes & development 2005;19(14):1668-73.
2005: Baggavalli P Somesh; James Reid; Wei-Feng Liu; T Max M Søgaard; Hediye Erdjument-Bromage; Paul Tempst; Jesper Q Svejstrup
Multiple mechanisms confining RNA polymerase II ubiquitylation to polymerases undergoing transcriptional arrest.
Cell 2005;121(6):913-23.
2005: Shalon E Babbitt; Alexi Kiss; Andrew E Deffenbaugh; Yie-Hwa Chang; Eric Bailly; Hediye Erdjument-Bromage; Paul Tempst; Tione Buranda; Larry A Sklar; Jennifer Baumler; Edward Gogol; Dorota Skowyra
ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle.
Cell 2005;121(4):553-65.
2005: THODORIS PETRAKIS; T Max M Søgaard; Hediye Erdjument-Bromage; Paul Tempst; Jesper Q Svejstrup
Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein.
The Journal of biological chemistry 2005;280(20):19454-60.
2005: Ji-Long Chen; Raymond V Fucini; Lynne Lacomis; Hediye Erdjument-Bromage; Paul Tempst; Mark Stamnes
Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles.
The Journal of cell biology 2005;169(3):383-9.
2005: Li Ma; Zhenbang Chen; Hediye Erdjument-Bromage; Paul Tempst; Pier Paolo Pandolfi
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis.
Cell 2005;121(2):179-93.
2005: Rushad Pavri; Brian Lewis; Tae Kyoung Kim; F Jeffrey Dilworth; Hediye Erdjument-Bromage; Paul Tempst; Gilbert de Murcia; Ronald Evans; Pierre Chambon; Danny Reinberg
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator.
Molecular cell 2005;18(1):83-96.
2005: Alexandre Costa; Yan Wang; Thomas C Dockendorff; Hediye Erdjument-Bromage; Paul Tempst; Paul Schedl; Thomas A Jongens
The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway.
Developmental cell 2005;8(3):331-42.
2005: Kyu Y Rhee; Hediye Erdjument-Bromage; Paul Tempst; Carl F Nathan
S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(2):467-72.
2005: Matthew Gamble; Hediye Erdjument-Bromage; Paul Tempst; Leonard P Freedman; Robert P Fisher
The histone chaperone TAF-I/SET/INHAT is required for transcription in vitro of chromatin templates.
Molecular and cellular biology 2005;25(2):797-807.
2004: Hasem Habelhah; Aaron Laine; Hediye Erdjument-Bromage; Paul Tempst; M Eric Gershwin; David D L Bowtell; Ze'ev Ronai
Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah.
The Journal of biological chemistry 2004;279(51):53782-8.
2004: Sharmistha Pal; Sheethal N Vishwanath; Hediye Erdjument-Bromage; Paul Tempst; Saïd Sif
Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes.
Molecular and cellular biology 2004;24(21):9630-45.
2004: Haiying Zhang; Daniel O Richardson; Douglas N Roberts; Rhea T Utley; Hediye Erdjument-Bromage; Paul Tempst; Jacques Côté; Bradley R Cairns
The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres.
Molecular and cellular biology 2004;24(21):9424-36.
2004: Hengbin Wang; Liangjun Wang; Hediye Erdjument-Bromage; Miguel Vidal; Paul Tempst; Richard S Jones; Yi Zhang
Role of histone H2A ubiquitination in Polycomb silencing.
Nature 2004;431(7010):873-8.
2004: Alejandro Vaquero; Michael Scher; Donghoon Lee; Hediye Erdjument-Bromage; Paul Tempst; Danny Reinberg
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.
Molecular cell 2004;16(1):93-105.
2004: Graeme L Cuthbert; Sylvain Daujat; Andrew W Snowden; Hediye Erdjument-Bromage; Teruki Hagiwara; Michiyuki Yamada; Robert Schneider; Philip D Gregory; Paul Tempst; Andrew J Bannister; Tony Kouzarides
Histone deimination antagonizes arginine methylation.
Cell 2004;118(5):545-53.
2004: Torill Høiby; Dimitra J Mitsiou; Huiqing Zhou; Hediye Erdjument-Bromage; Paul Tempst; Hendrik G Stunnenberg
Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.
The EMBO journal 2004;23(15):3083-91.
2004: Dos D. Sarbassov; Siraj M Ali; Do-Hyung Kim; David A Guertin; Robert R Latek; Hediye Erdjument-Bromage; Paul Tempst; David M Sabatini
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
Current biology : CB 2004;14(14):1296-302.
2004: Benjamin W Guidi; Gudrun Bjornsdottir; Daniel C Hopkins; Lynne Lacomis; Hediye Erdjument-Bromage; Paul Tempst; Lawrence C Myers
Mutual targeting of mediator and the TFIIH kinase Kin28.
The Journal of biological chemistry 2004;279(28):29114-20.
2004: Koh Nakayama; Ian J Frew; Mette Hagensen; Marianne Skals; Hasem Habelhah; Anindita Bhoumik; Takayuki Kadoya; Hediye Erdjument-Bromage; Paul Tempst; Peter Frappell; David D L Bowtell; Ze'ev Ronai
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia.
Cell 2004;117(7):941-52.
2004: Eric Devroe; Hediye Erdjument-Bromage; Paul Tempst; Pamela A Silver
Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.
The Journal of biological chemistry 2004;279(23):24444-51.
2004: Ji-Long Chen; Lynne Lacomis; Hediye Erdjument-Bromage; Paul Tempst; Mark Stamnes
Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF/coatomer-dependent actin polymerization on Golgi membranes.
FEBS letters 2004;566(1-3):281-6.
2004: Lisette Acevedo; Jun Yu; Hediye Erdjument-Bromage; Robert Qing Miao; Ji-Eun Kim; David J Fulton; Paul Tempst; Stephen M Strittmatter; William C Sessa
A new role for Nogo as a regulator of vascular remodeling.
Nature medicine 2004;10(4):382-8.
2004: Margaret M Kasten; Heather Szerlong; Hediye Erdjument-Bromage; Paul Tempst; Michel Werner; Bradley R Cairns
Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys14.
The EMBO journal 2004;23(6):1348-59.
2004: Stéphane Hausmann; Hediye Erdjument-Bromage; Stewart Shuman
Schizosaccharomyces pombe carboxyl-terminal domain (CTD) phosphatase Fcp1: distributive mechanism, minimal CTD substrate, and active site mapping.
The Journal of biological chemistry 2004;279(12):10892-900.
2004: Melina Fan; James Rhee; Julie St-Pierre; Christoph Handschin; Pere Puigserver; Jiandie Lin; Sibylle Jäeger; Hediye Erdjument-Bromage; Paul Tempst; Bruce M Spiegelman
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.
Genes & development 2004;18(3):278-89.
2003: Jian Chen; Juan M Cárcamo; Oriana Bórquez-Ojeda; Hediye Erdjument-Bromage; Paul Tempst; David W Golde
The laminin receptor modulates granulocyte-macrophage colony-stimulating factor receptor complex formation and modulates its signaling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14000-5.
2003: Yuichiro Takagi; Hirofumi Komori; Wei-Hau Chang; Andy Hudmon; Hediye Erdjument-Bromage; Paul Tempst; Roger D Kornberg
Revised subunit structure of yeast transcription factor IIH (TFIIH) and reconciliation with human TFIIH.
The Journal of biological chemistry 2003;278(45):43897-900.
2003: Sharmistha Pal; Romy Yun; Antara Datta; Lynne Lacomis; Hediye Erdjument-Bromage; Jitendra Kumar; Paul Tempst; Saïd Sif
mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.
Molecular and cellular biology 2003;23(21):7475-87.
2003: Christopher S Gilbert; Michael van den Bosch; Catherine Green; Jorge E Vialard; Muriel Grenon; Hediye Erdjument-Bromage; Paul Tempst; Noel F Lowndes
The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function.
EMBO reports 2003;4(10):953-8.
2003: Hengbin Wang; Woojin An; Ru Cao; Li Xia; Hediye Erdjument-Bromage; Bruno Chatton; Paul Tempst; Robert G Roeder; Yi Zhang
mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression.
Molecular cell 2003;12(2):475-87.
2003: Mercedes Gallardo; Rosa Luna; Hediye Erdjument-Bromage; Paul Tempst; Andres Aguilera
Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism.
The Journal of biological chemistry 2003;278(26):24225-32.
2003: Valérie Chesneau; J David Becherer; Yufang Zheng; Hediye Erdjument-Bromage; Paul Tempst; Carl P Blobel
Catalytic properties of ADAM19.
The Journal of biological chemistry 2003;278(25):22331-40.
2003: Jessica Martinez; Ines Moeller; Hediye Erdjument-Bromage; Paul Tempst; Brett Lauring
Parkinson's disease-associated alpha-synuclein is a calmodulin substrate.
The Journal of biological chemistry 2003;278(19):17379-87.
2003: Do-Hyung Kim; Dos D. Sarbassov; Siraj M Ali; Robert R Latek; Kalyani V P Guntur; Hediye Erdjument-Bromage; Paul Tempst; David M Sabatini
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
Molecular cell 2003;11(4):895-904.
2003: Christian Schwerk; Jayendra Prasad; Kurt Degenhardt; Hediye Erdjument-Bromage; Eileen White; Paul Tempst; Vincent J Kidd; James L Manley; Jill Lahti; Danny Reinberg
ASAP, a novel protein complex involved in RNA processing and apoptosis.
Molecular and cellular biology 2003;23(8):2981-90.
2003: Erika M Friedl; William Stratton Lane; Hediye Erdjument-Bromage; Paul Tempst; Danny Reinberg
The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2328-33.
2003: James Hsieh; Patricia Ernst; Hediye Erdjument-Bromage; Paul Tempst; Stanley J Korsmeyer
Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization.
Molecular and cellular biology 2003;23(1):186-94.
2002: Erik David Andrulis; Janis Werner; Arpi Nazarian; Hediye Erdjument-Bromage; Paul Tempst; John T Lis
The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila.
Nature 2002;420(6917):837-41.
2002: Jing Zhu; Carl Nathan; Wenwen Jin; Davis Sim; Gillian S Ashcroft; Sharon M Wahl; Lynne Lacomis; Hediye Erdjument-Bromage; Paul Tempst; Clifford D Wright; Aihao Ding
Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair.
Cell 2002;111(6):867-78.
2002: Andrei Kuzmichev; Kenichi Nishioka; Hediye Erdjument-Bromage; Paul Tempst; Danny Reinberg
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.
Genes & development 2002;16(22):2893-905.
2002: Tilman Borggrefe; Ralph Davis; Hediye Erdjument-Bromage; Paul Tempst; Roger D Kornberg
A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast.
The Journal of biological chemistry 2002;277(46):44202-7.
2002: Jun Yang; David Goetz; Jau Yi Li; Wenge Wang; Kiyoshi Mori; Daria Setlik; Tonggong Du; Hediye Erdjument-Bromage; Paul Tempst; Roland Strong; Jonathan Barasch
An iron delivery pathway mediated by a lipocalin.
Molecular cell 2002;10(5):1045-56.
2002: Ru Cao; Liangjun Wang; Hengbin Wang; Li Xia; Hediye Erdjument-Bromage; Paul Tempst; Richard S Jones; Yi Zhang
Role of histone H3 lysine 27 methylation in Polycomb-group silencing.
Science (New York, N.Y.) 2002;298(5595):1039-43.
2002: Lawrence C Myers; Lynne Lacomis; Hediye Erdjument-Bromage; Paul Tempst
The yeast capping enzyme represses RNA polymerase II transcription.
Molecular cell 2002;10(4):883-94.
2002: Stuart S Levine; Alona Weiss; Hediye Erdjument-Bromage; Zhaohui Shao; Paul Tempst; Robert E Kingston
The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.
Molecular and cellular biology 2002;22(17):6070-8.
2002: Do-Hyung Kim; Dos D. Sarbassov; Siraj M Ali; Jessie E King; Robert R Latek; Hediye Erdjument-Bromage; Paul Tempst; David M Sabatini
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Cell 2002;110(2):163-75.
2002: Jia Fang; Qin Feng; Carrie S Ketel; Hengbin Wang; Ru Cao; Li Xia; Hediye Erdjument-Bromage; Paul Tempst; Jeffrey A Simon; Yi Zhang
Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase.
Current biology : CB 2002;12(13):1086-99.
2002: Qin Feng; Hengbin Wang; Huck-Hui Ng; Hediye Erdjument-Bromage; Paul Tempst; Kevin Struhl; Yi Zhang
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.
Current biology : CB 2002;12(12):1052-8.
2002: Huck-Hui Ng; Qin Feng; Hengbin Wang; Hediye Erdjument-Bromage; Paul Tempst; Yi Zhang; Kevin Struhl
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.
Genes & development 2002;16(12):1518-27.
2002: Kenichi Nishioka; Judd C Rice; Kavitha Sarma; Hediye Erdjument-Bromage; Janis Werner; Yanming Wang; Sergei Chuikov; Pablo Valenzuela; Paul Tempst; Ruth Steward; John T Lis; C David Allis; Danny Reinberg
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin.
Molecular cell 2002;9(6):1201-13.
2002: Heidi C E Welch; W John Coadwell; Chris D Ellson; Gordon ferguson; Simon R Andrews; Hediye Erdjument-Bromage; Paul Tempst; Phillip T Hawkins; Len R Stephens
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac.
Cell 2002;108(6):809-21.
2002: G Sebastiaan Winkler; Arnold Kristjuhan; Hediye Erdjument-Bromage; Paul Tempst; Jesper Q Svejstrup
Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3517-22.
2002: G Sebastiaan Winkler; Lynne Lacomis; John Philip; Hediye Erdjument-Bromage; Jesper Q Svejstrup; Paul Tempst
Isolation and mass spectrometry of transcription factor complexes.
Methods (San Diego, Calif.) 2002;26(3):260-9.
2002: Elies C Woudstra; Chris Gilbert; Jane Fellows; Lars Jansen; Jaap Brouwer; Hediye Erdjument-Bromage; Paul Tempst; Jesper Q Svejstrup
A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage.
Nature 2002;415(6874):929-33.
2002: Kenichi Nishioka; Sergei Chuikov; Kavitha Sarma; Hediye Erdjument-Bromage; C David Allis; Paul Tempst; Danny Reinberg
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.
Genes & development 2002;16(4):479-89.
2002: Ruslana Bryk; Christopher D Lima; Hediye Erdjument-Bromage; Paul Tempst; Carl Nathan
Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.
Science (New York, N.Y.) 2002;295(5557):1073-7.
2002: Andrei Kuzmichev; Yi Zhang; Hediye Erdjument-Bromage; Paul Tempst; Danny Reinberg
Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).
Molecular and cellular biology 2002;22(3):835-48.
2002: Nicola A Hawkes; Gabriel Otero; G Sebastiaan Winkler; Nick Marshall; Michael E Dahmus; Daniel Krappmann; Claus Scheidereit; Claire L Thomas; Giampietro Schiavo; Hediye Erdjument-Bromage; Paul Tempst; Jesper Q Svejstrup
Purification and characterization of the human elongator complex.
The Journal of biological chemistry 2002;277(4):3047-52.
2002: Sonja Krugmann; Karen E Anderson; SH Ridley; N Risso; Alex McGregor; John Coadwell; Keith Davidson; Alicia Eguinoa; Chris D Ellson; Peter Lipp; Maria Manifava; Nicholas T Ktistakis; GF Painter; Jan W Thuring; Matthew A Cooper; Ze-Yi Lim; Andrew B Holmes; Stephen K Dove; Robert H Michell; A Grewal; A Nazarian; Hediye Erdjument-Bromage; Paul Tempst; Len R Stephens; Phillip T Hawkins
Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.
Molecular cell 2002;9(1):95-108.
2002: Qin Feng; Ru Cao; Li Xia; Hediye Erdjument-Bromage; Paul Tempst; Yi Zhang
Identification and functional characterization of the p66/p68 components of the MeCP1 complex.
Molecular and cellular biology 2002;22(2):536-46.
2001: Hongbing Wang; Ru Cao; Li Xia; Hediye Erdjument-Bromage; Christoph H Borchers; Paul Tempst; Yi Zhang
Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase.
Molecular cell 2001;8(6):1207-17.
2001: Y Miyazaki; Piernicola Boccuni; Shifeng Mao; Jianjun Zhang; Hediye Erdjument-Bromage; Paul Tempst; Hiroaki Kiyokawa; Stephen D Nimer
Cyclin A-dependent phosphorylation of the ETS-related protein, MEF, restricts its activity to the G1 phase of the cell cycle.
The Journal of biological chemistry 2001;276(44):40528-36.
2001: SH Ridley; Nicholas T Ktistakis; Keith Davidson; Karen E Anderson; Maria Manifava; Chris D Ellson; Peter Lipp; Martin D Bootman; John Coadwell; A Nazarian; Hediye Erdjument-Bromage; Paul Tempst; Matthew A Cooper; Jan W Thuring; Ze-Yi Lim; Andrew B Holmes; Len R Stephens; Phillip T Hawkins
FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments.
Journal of cell science 2001;114(Pt 22):3991-4000.
2001: G Sebastiaan Winkler; THODORIS PETRAKIS; S Ethelberg; M Tokunaga; Hediye Erdjument-Bromage; Paul Tempst; Jesper Q Svejstrup
RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes.
The Journal of biological chemistry 2001;276(35):32743-9.
2001: Xiquan Liang; Arpi Nazarian; Hediye Erdjument-Bromage; William G Bornmann; Paul Tempst; Marilyn D Resh
Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction.
The Journal of biological chemistry 2001;276(33):30987-94.
2001: Yiming Li; Yuichiro Takagi; Y Jiang; M Tokunaga; Hediye Erdjument-Bromage; Paul Tempst; Roger D Kornberg
A multiprotein complex that interacts with RNA polymerase II elongator.
The Journal of biological chemistry 2001;276(32):29628-31.
2001: AJ Saurin; Zhaohui Shao; Hediye Erdjument-Bromage; Paul Tempst; Robert E Kingston
A Drosophila Polycomb group complex includes Zeste and dTAFII proteins.
Nature 2001;412(6847):655-60.
2001: Hongbing Wang; Zhi-Qing Huang; Li Xia; Qin Feng; Hediye Erdjument-Bromage; Brian D Strahl; Scott D Briggs; C David Allis; Jiemin Wong; Paul Tempst; Yi Zhang
Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor.
Science (New York, N.Y.) 2001;293(5531):853-7.
2001: Stéphane Larochelle; Jian Chen; R Knights; J Pandur; Patrick Morcillo; Hediye Erdjument-Bromage; Paul Tempst; Beat Suter; Robert P Fisher
T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity.
The EMBO journal 2001;20(14):3749-59.
2001: Chris D Ellson; S Gobert-Gosse; Karen E Anderson; Keith Davidson; Hediye Erdjument-Bromage; Paul Tempst; Jan W Thuring; Matthew A Cooper; Ze-Yi Lim; Andrew B Holmes; PR Gaffney; John Coadwell; Edwin R Chilvers; Phillip T Hawkins; Len R Stephens
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox).
Nature cell biology 2001;3(7):679-82.
2001: Hill Melinda; Alisha Schlichter; D Roberts; Hediye Erdjument-Bromage; Paul Tempst; Bradley R Cairns
A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control.
Molecular cell 2001;7(4):741-51.
2000: C Hikita; Soundarapandian Vijayakumar; Jiro Takito; Hediye Erdjument-Bromage; Paul Tempst; Qais Al-Awqati
Induction of terminal differentiation in epithelial cells requires polymerization of hensin by galectin 3.
The Journal of cell biology 2000;151(6):1235-46.
2000: Karen E Anderson; Peter Lipp; Martin D Bootman; SH Ridley; John Coadwell; L Rönnstrand; Johan Lennartsson; Andrew B Holmes; GF Painter; Jan W Thuring; Ze-Yi Lim; Hediye Erdjument-Bromage; A Grewal; Paul Tempst; Len R Stephens; Phillip T Hawkins
DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma-membrane recruitment and endocytosis upon cell stimulation.
Current biology : CB 2000;10(22):1403-12.
2000: Sebastián Chávez; Traude Beilharz; Ana G Rondón; Hediye Erdjument-Bromage; Paul Tempst; J Q Svejstrup; Trevor Lithgow; Andres Aguilera
A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae.
The EMBO journal 2000;19(21):5824-34.
2000: D W O'Neill; Stuti Schoetz; Rocio A Lopez; M Castle; L Rabinowitz; Erika Shor; D Krawchuk; Mary Goll; Manfred Renz; Hans Peter Seelig; S Han; R H Seong; S D Park; Theodora Agalioti; Nikhil C Munshi; Dimitris Thanos; Hediye Erdjument-Bromage; Paul Tempst; Arthur Bank
An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells.
Molecular and cellular biology 2000;20(20):7572-82.
2000: Raymond V Fucini; A Navarrete; C Vadakkan; Lynne Lacomis; Hediye Erdjument-Bromage; Paul Tempst; Mark Stamnes
Activated ADP-ribosylation factor assembles distinct pools of actin on golgi membranes.
The Journal of biological chemistry 2000;275(25):18824-9.
2000: Jane Fellows; Hediye Erdjument-Bromage; Paul Tempst; Jesper Q Svejstrup
The Elp2 subunit of elongator and elongating RNA polymerase II holoenzyme is a WD40 repeat protein.
The Journal of biological chemistry 2000;275(17):12896-9.
2000: Catherine Green; Hediye Erdjument-Bromage; Paul Tempst; Noel F Lowndes
A novel Rad24 checkpoint protein complex closely related to replication factor C.
Current biology : CB 2000;10(1):39-42.
1999: Jonathan Barasch; Jun Yang; C B Ware; T Taga; K Yoshida; Hediye Erdjument-Bromage; Paul Tempst; Elvira Parravicini; S Malach; Tsvi Aranoff; Juan A Oliver
Mesenchymal to epithelial conversion in rat metanephros is induced by LIF.
Cell 1999;99(4):377-86.
1999: Bradley R Cairns; Alisha Schlichter; Hediye Erdjument-Bromage; Paul Tempst; Roger D Kornberg; fred winston
Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains.
Molecular cell 1999;4(5):715-23.
1999: Yi Zhang; H H Ng; Hediye Erdjument-Bromage; Paul Tempst; A Bird; Danny Reinberg
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
Genes & development 1999;13(15):1924-35.
1999: Birgitte O Wittschieben; Gabriel Otero; Thérèse de Bizemont; Jane Fellows; Hediye Erdjument-Bromage; R Ohba; Yiming Li; C D Allis; Paul Tempst; Jesper Q Svejstrup
A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme.
Molecular cell 1999;4(1):123-8.
1999: Y Webb; X Zhou; Lang Ngo; Virginia W Cornish; J Stahl; Hediye Erdjument-Bromage; Paul Tempst; Richard A Rifkind; Paul A Marks; Ronald Breslow; Victoria M Richon
Photoaffinity labeling and mass spectrometry identify ribosomal protein S3 as a potential target for hybrid polar cytodifferentiation agents.
The Journal of biological chemistry 1999;274(20):14280-7.
1999: Lawrence Lum; BR Wong; Régis Josien; J David Becherer; Hediye Erdjument-Bromage; Johannes Schlöndorff; Paul Tempst; Yongwon Choi; Carl P Blobel
Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival.
The Journal of biological chemistry 1999;274(19):13613-8.
1999: Jonathan Barasch; Jun Yang; J Qiao; Paul Tempst; Hediye Erdjument-Bromage; W Leung; Juan A Oliver
Tissue inhibitor of metalloproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros.
The Journal of clinical investigation 1999;103(9):1299-307.
1999: Christophe Rachez; Bryan Lemon; Z Suldan; VC Bromleigh; Matthew Gamble; Anders M Näär; Hediye Erdjument-Bromage; Paul Tempst; Leonard P Freedman
Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.
Nature 1999;398(6730):824-8.
1999: J Zeng; Mindong Ren; D Gravotta; C De Lemos-Chiarandini; M Lui; Hediye Erdjument-Bromage; Paul Tempst; G Xu; Tian H. Shen; T Morimoto; Milton Adesnik; David D Sabatini
Identification of a putative effector protein for rab11 that participates in transferrin recycling.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2840-5.
1999: M Roghani; J David Becherer; Marcia moss; R E Atherton; Hediye Erdjument-Bromage; Joaquín Arribas; R Kevin Blackburn; Gisela Weskamp; Paul Tempst; Carl P Blobel
Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity.
The Journal of biological chemistry 1999;274(6):3531-40.
1999: David O'Neill; Jerry Yang; Hediye Erdjument-Bromage; K Bornschlegel; Paul Tempst; Arthur Bank
Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):349-54.
1999: Hediye Erdjument-Bromage; M Lui; Lynne Lacomis; Paul Tempst
Characterizing proteins from 2-DE gels by internal sequence analysis of peptide fragments. Strategies for microsample handling.
Methods in molecular biology (Clifton, N.J.) 1999;112():467-72.
1999: Gabriel Otero; Jane Fellows; Yiming Li; Thérèse de Bizemont; A M Dirac; C M Gustafsson; Hediye Erdjument-Bromage; Paul Tempst; Jesper Q Svejstrup
Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.
Molecular cell 1999;3(1):109-18.
1998: Hediye Erdjument-Bromage; M Lui; Lynne Lacomis; A Grewal; Roland S Annan; Dean E McNulty; Steve Carr; Paul Tempst
Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis.
Journal of chromatography. A 1998;826(2):167-81.
1998: Claes M Gustafsson; Lawrence C Myers; Jenny Beve; Henrik Spåhr; M Lui; Hediye Erdjument-Bromage; Paul Tempst; Roger D Kornberg
Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae.
The Journal of biological chemistry 1998;273(47):30851-4.
1998: Bradley R Cairns; Hediye Erdjument-Bromage; Paul Tempst; fred winston; Roger D Kornberg
Two actin-related proteins are shared functional components of the chromatin-remodeling complexes RSC and SWI/SNF.
Molecular cell 1998;2(5):639-51.
1998: Y W Jiang; P Veschambre; Hediye Erdjument-Bromage; Paul Tempst; J W Conaway; R C Conaway; Roger D Kornberg
Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8538-43.
1998: Christophe Rachez; Z Suldan; J Ward; Chao-Pei Betty Chang; Darya Burakov; Hediye Erdjument-Bromage; Paul Tempst; Leonard P Freedman
A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system.
Genes & development 1998;12(12):1787-800.
1998: Yi Zhang; Zu-Wen Sun; Rabah Iratni; Hediye Erdjument-Bromage; Paul Tempst; Michael Hampsey; Danny Reinberg
SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex.
Molecular cell 1998;1(7):1021-31.
1998: Len Stephens; Karen Anderson; David Stokoe; Hediye Erdjument-Bromage; GF Painter; Andrew B Holmes; PR Gaffney; CB Reese; F McCormick; Paul Tempst; John Coadwell; Phillip T Hawkins
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.
Science (New York, N.Y.) 1998;279(5351):710-4.
1998: Lawrence C Myers; Claes M Gustafsson; David A Bushnell; M Lui; Hediye Erdjument-Bromage; Paul Tempst; Roger D Kornberg
The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain.
Genes & development 1998;12(1):45-54.
1997: I Paek; Lelio Orci; Mariella Ravazzola; Hediye Erdjument-Bromage; Mylene Amherdt; Paul Tempst; Thomas H Söllner; James E Rothman
ERS-24, a mammalian v-SNARE implicated in vesicle traffic between the ER and the Golgi.
The Journal of cell biology 1997;137(5):1017-28.
1997: Alexey G Ryazanov; MD Ward; C E Mendola; Karen S Pavur; Maxim V Dorovkov; M Wiedmann; Hediye Erdjument-Bromage; Paul Tempst; TG Parmer; C R Prostko; F Joseph Germino; William N Hait
Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):4884-9.
1997: H Niu; Hediye Erdjument-Bromage; Z Q Pan; S H Lee; Paul Tempst; Jerard Hurwitz
Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitro.
The Journal of biological chemistry 1997;272(19):12634-41.
1997: H Zhong; H SuYang; Hediye Erdjument-Bromage; Paul Tempst; Sankar Ghosh
The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism.
Cell 1997;89(3):413-24.
1997: Yi Zhang; Rabah Iratni; Hediye Erdjument-Bromage; Paul Tempst; Danny Reinberg
Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.
Cell 1997;89(3):357-64.
1997: Len R Stephens; Alicia Eguinoa; Hediye Erdjument-Bromage; M Lui; F Cooke; John Coadwell; A S Smrcka; M Thelen; Karen A Cadwallader; Paul Tempst; Phillip T Hawkins
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101.
Cell 1997;89(1):105-14.
1997: Claes M Gustafsson; Lawrence C Myers; Yiming Li; M J Redd; M Lui; Hediye Erdjument-Bromage; Paul Tempst; Roger D Kornberg
Identification of Rox3 as a component of mediator and RNA polymerase II holoenzyme.
The Journal of biological chemistry 1997;272(1):48-50.
1996: Bradley R Cairns; Yahli Lorch; Yiming Li; M Zhang; Lynne Lacomis; Hediye Erdjument-Bromage; Paul Tempst; J Du; B Laurent; Roger D Kornberg
RSC, an essential, abundant chromatin-remodeling complex.
Cell 1996;87(7):1249-60.
1996: M Lui; Paul Tempst; Hediye Erdjument-Bromage
Methodical analysis of protein-nitrocellulose interactions to design a refined digestion protocol.
Analytical biochemistry 1996;241(2):156-66.
1996: M Mayhew; A C da Silva; J Martin; Hediye Erdjument-Bromage; Paul Tempst; F Ulrich Hartl
Protein folding in the central cavity of the GroEL-GroES chaperonin complex.
Nature 1996;379(6564):420-6.
1995: Wayne Patton; Hediye Erdjument-Bromage; Andrew R Marks; Paul Tempst; Mark B Taubman
Components of the protein synthesis and folding machinery are induced in vascular smooth muscle cells by hypertrophic and hyperplastic agents. Identification by comparative protein phenotyping and microsequencing.
The Journal of biological chemistry 1995;270(36):21404-10.
1995: JP Simon; IE Ivanov; Mindong Ren; J Zeng; Bo Shopsin; D Hersh; Paul Tempst; Hediye Erdjument-Bromage; M Lui; C De Lemos-Chiarandini
Regulation of post-Golgi vesicle production in an in vitro system.
Cold Spring Harbor symposia on quantitative biology 1995;60():179-95.
1994: Hediye Erdjument-Bromage; M Lui; DM Sabatini; Solomon H Snyder; Paul Tempst
High-sensitivity sequencing of large proteins: partial structure of the rapamycin-FKBP12 target.
Protein science : a publication of the Protein Society 1994;3(12):2435-46.
1994: P Casteels; J Romagnolo; M Castle; K Casteels-Josson; Hediye Erdjument-Bromage; Paul Tempst
Biodiversity of apidaecin-type peptide antibiotics. Prospects of manipulating the antibacterial spectrum and combating acquired resistance.
The Journal of biological chemistry 1994;269(42):26107-15.
1994: Wayne Patton; L Lam; Q Su; M Lui; Hediye Erdjument-Bromage; Paul Tempst
Metal chelates as reversible stains for detection of electroblotted proteins: application to protein microsequencing and immunoblotting.
Analytical biochemistry 1994;220(2):324-35.
1994: C Elicone; M Lui; S Geromanos; Hediye Erdjument-Bromage; Paul Tempst
Microbore reversed-phase high-performance liquid chromatographic purification of peptides for combined chemical sequencing-laser-desorption mass spectrometric analysis.
Journal of chromatography. A 1994;676(1):121-37.
1994: Kornelia Polyak; M H Lee; Hediye Erdjument-Bromage; Andrew Koff; James M Roberts; Paul Tempst; Joan Massagué
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.
Cell 1994;78(1):59-66.
1994: DM Sabatini; Hediye Erdjument-Bromage; M Lui; Paul Tempst; Solomon H Snyder
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs.
Cell 1994;78(1):35-43.
1993: Thomas H Söllner; S W Whiteheart; M Brunner; Hediye Erdjument-Bromage; S Geromanos; Paul Tempst; James E Rothman
SNAP receptors implicated in vesicle targeting and fusion.
Nature 1993;362(6418):318-24.
1992: Judith Frydman; E Nimmesgern; Hediye Erdjument-Bromage; J S Wall; Paul Tempst; F Ulrich Hartl
Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits.
The EMBO journal 1992;11(13):4767-78.