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Michael Erdos

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Publications

TOP 3
Rachel Patton McCord; Ashley Nazario-Toole; Ye Zhan; Haoyue Zhang; Peter S Chines; Francis S Collins; Job Dekker; Michael R Erdos; Kan Cao
Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome.
Guanjie Chen; Michael F Christman; Ayo Doumatey; Michael R Erdos; Norman P Gerry; Alan Herbert; Hanxia Huang; Edward Ramos; Adebowale Adeyemo; Amy Bentley; Daniel Shriner; Jie Zhou; Charles Rotimi
Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans.
Ayo P Doumatey; Benjamin A Eghan; Michael R Erdos; Olufemi Fasanmade; Norman P Gerry; Hanxia Huang; Thomas Johnson; Godfrey Okafor; Johnnie Oli; Joseph Acheampong; Clement Adebamowo; Jokotade Adeleye; Adebowale Adeyemo; Kofi Agyenim-Boateng; Albert Amoah; Williams Balogun; Guanjie Chen; Michael F Christman; Daniel Shriner; Fasil Tekola Ayele; Jie Zhou; Charles N Rotimi
C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans.

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All Publications

2013: Rachel Patton McCord; Ashley Nazario-Toole; Ye Zhan; Haoyue Zhang; Peter S Chines; Francis S Collins; Job Dekker; Michael R Erdos; Kan Cao
Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome.
Genome research 2013;23(2):260-9.
2012: Guanjie Chen; Michael F Christman; Ayo Doumatey; Michael R Erdos; Norman P Gerry; Alan Herbert; Hanxia Huang; Edward Ramos; Adebowale Adeyemo; Amy Bentley; Daniel Shriner; Jie Zhou; Charles Rotimi
Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans.
Human molecular genetics 2012;21(20):4530-6.
2012: Ayo P Doumatey; Benjamin A Eghan; Michael R Erdos; Olufemi Fasanmade; Norman P Gerry; Hanxia Huang; Thomas Johnson; Godfrey Okafor; Johnnie Oli; Joseph Acheampong; Clement Adebamowo; Jokotade Adeleye; Adebowale Adeyemo; Kofi Agyenim-Boateng; Albert Amoah; Williams Balogun; Guanjie Chen; Michael F Christman; Daniel Shriner; Fasil Tekola Ayele; Jie Zhou; Charles N Rotimi
C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans.
Human molecular genetics 2012;21(13):3063-72.
2012: Karen N Conneely; Michael R Erdos; Bard J Geesaman; Thomas T Perls; Annibale A Puca; Paola Sebastiani; Nadia Solovieff; Amy J Swift; Gil Atzmon; Clinton T Baldwin; Nir Barzilai; Michael Boehnke; Temuri Budagov; Brian C Capell; Francis S Collins
Human longevity and common variations in the LMNA gene: a meta-analysis.
Aging cell 2012;11(3):475-81.
2012: Fasil Tekola Ayele; Daniel Shriner; Jie Zhou; Joseph Acheampong; Clement Adebamowo; Jokotade Adeleye; Adebowale Adeyemo; Kofi Agyenim-Boateng; Albert Amoah; Williams Balogun; Bashira Charles; Guanjie Chen; Michael F Christman; Ayo Doumatey; Benjamin A Eghan; Michael R Erdos; Olufemi Fasanmade; Norman P Gerry; Alan Herbert; Hanxia Huang; Thomas Johnson; Godfrey Okafor; Johnnie Oli; Charles N Rotimi
Genome-wide associated loci influencing interleukin (IL)-10, IL-1Ra, and IL-6 levels in African Americans.
Immunogenetics 2012;64(5):351-9.
2012: Guanjie Chen; Michael F Christman; Ayo Doumatey; Michael R Erdos; Norman P Gerry; Alan Herbert; Hanxia Huang; Edward Ramos; Adebowale Adeyemo; Amy R Bentley; Bashira A Charles; Daniel Shriner; Huichun Xu; Jie Zhou; Charles N Rotimi
UGT1A1 is a major locus influencing bilirubin levels in African Americans.
European journal of human genetics : EJHG 2012;20(4):463-8.
2012: Daniel Shriner; Jie Zhou; Adebowale Adeyemo; Guanjie Chen; Michael F Christman; Ayo Doumatey; Michael R Erdos; Norman P Gerry; Alan Herbert; Hanxia Huang; Charles N Rotimi
Multiple loci associated with renal function in African Americans.
PloS one 2012;7(9):e45112.
2011: Kan Cao; Cecilia D Blair; Michael R Erdos; John J Graziotto; Dimitri Krainc; Joseph R Mazzulli; Francis S Collins
Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.
Science translational medicine 2011;3(89):89ra58.
2010: Michael L Stitzel; Praveen Sethupathy; Daniel S Pearson; Peter S Chines; Lingyun Song; Michael R Erdos; Ryan Welch; Stephen C J Parker; Alan P Boyle; Laura J Scott; Elliott H Margulies; Michael Boehnke; Terrence S Furey; Gregory E Crawford; Francis S Collins
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci.
Cell metabolism 2010;12(5):443-55.
2009: Pekka Taimen; Katrin Pfleghaar; Takeshi Shimi; Dorothee Möller; Kfir Ben-Harush; Michael R Erdos; Stephen Adam; Harald Herrmann; Ohad Medalia; Francis S Collins; Anne E Goldman; Robert D Goldman
A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(49):20788-93.
2009: Ludmila Prokunina-Olsson; Cullan Welch; Ola Hansson; Neeta Adhikari; Laura J Scott; Nicolle Usher; Maurine Tong; Andrew Sprau; Amy Swift; Lori L Bonnycastle; Michael R Erdos; Zhi He; Richa Saxena; Brennan Harmon; Olga Kotova; Eric Hoffman; David Altshuler; Leif Groop; Michael Boehnke; Francis S Collins; Jennifer L Hall
Tissue-specific alternative splicing of TCF7L2.
Human molecular genetics 2009;18(20):3795-804.
2008: Brian C Capell; Michelle Olive; Michael R Erdos; Kan Cao; Dina A Faddah; Urraca L Tavarez; Karen N Conneely; Xuan Qu; Hong San; Santhi Ganesh; Xiaoyan Chen; Hedwig Avallone; Frank D Kolodgie; Renu Virmani; Elizabeth G Nabel; Francis S Collins
A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(41):15902-7.
2008: Hanna Sagelius; Ylva Rosengardten; Mubashir Hanif; Michael R Erdos; Björn Rozell; Francis S Collins; Maria Eriksson
Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease.
Journal of cell science 2008;121(Pt 7):969-78.
2007: Kan Cao; Brian C Capell; Michael R Erdos; Karima Djabali; Francis S Collins
A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):4949-54.
2007: Cristen J Willer; Lori L Bonnycastle; Karen N Conneely; William L Duren; Anne U Jackson; Laura J Scott; Narisu Narisu; Peter S Chines; Andrew D Skol; Heather M Stringham; John Petrie; Michael R Erdos; Amy J Swift; Sareena T Enloe; Andrew G Sprau; Eboni Smith; Maurine Tong; Kimberly F Doheny; Elizabeth W Pugh; Richard Watanabe; Thomas A Buchanan; Timo T Valle; Richard N Bergman; Jaakko Tuomilehto; Karen L Mohlke; Francis S Collins; Michael Boehnke
Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes.
Diabetes 2007;56(1):256-64.
2006: Laura J Scott; Lori L Bonnycastle; Cristen J Willer; Andrew G Sprau; Anne U Jackson; Narisu Narisu; William L Duren; Peter S Chines; Heather M Stringham; Michael R Erdos; Timo T Valle; Jaakko Tuomilehto; Richard N Bergman; Karen L Mohlke; Francis S Collins; Michael Boehnke
Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample.
Diabetes 2006;55(9):2649-53.
2006: Lori L Bonnycastle; Cristen J Willer; Karen N Conneely; Anne U Jackson; Cecily P Burrill; Richard Watanabe; Peter S Chines; Narisu Narisu; Laura J Scott; Sareena T Enloe; Amy J Swift; William L Duren; Heather M Stringham; Michael R Erdos; Nancy L Riebow; Thomas A Buchanan; Timo T Valle; Jaakko Tuomilehto; Richard N Bergman; Karen L Mohlke; Michael Boehnke; Francis S Collins
Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns.
Diabetes 2006;55(9):2534-40.
2006: Gregory E Crawford; Sean Davis; Peter C Scacheri; Gabriel Renaud; Mohamad J Halawi; Michael R Erdos; Roland Green; Paul S Meltzer; Tyra G Wolfsberg; Francis S Collins
DNase-chip: a high-resolution method to identify DNase I hypersensitive sites using tiled microarrays.
Nature methods 2006;3(7):503-9.
2006: Dale K Shumaker; Thomas Dechat; Alexander Kohlmaier; Stephen Adam; Matthew R Bozovsky; Michael R Erdos; Maria Eriksson; Anne E Goldman; Satya Khuon; Francis S Collins; Thomas Jenuwein; Robert D Goldman
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(23):8703-8.
2006: Renee Varga; Maria Eriksson; Michael R Erdos; Michelle Olive; Ingrid A Harten; Frank D Kolodgie; Brian C Capell; Jun Cheng; Dina Faddah; Stacie Perkins; Hedwig Avallone; Hong San; Xuan Qu; Santhi Ganesh; Leslie B Gordon; Renu Virmani; Thomas N Wight; Elizabeth G Nabel; Francis S Collins
Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3250-5.
2005: Karen L Mohlke; Anne U Jackson; Laura J Scott; Erin C Peck; Yong D Suh; Peter S Chines; Richard Watanabe; Thomas A Buchanan; Karen N Conneely; Michael R Erdos; Narisu Narisu; Sareena Enloe; Timo T Valle; Jaakko Tuomilehto; Richard N Bergman; Michael Boehnke; Francis S Collins
Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns.
Human genetics 2005;118(2):245-54.
2005: Brian C Capell; Michael R Erdos; James P Madigan; James J Fiordalisi; Renee Varga; Karen N Conneely; Leslie B Gordon; Channing J Der; Adrienne D Cox; Francis S Collins
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12879-84.
2004: Robert D Goldman; Dale K Shumaker; Michael R Erdos; Maria Eriksson; Anne E Goldman; Leslie B Gordon; Yosef Gruenbaum; Satya Khuon; Melissa Mendez; Renee Varga; Francis S Collins
Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(24):8963-8.
2004: Kaisa Silander; Karen L Mohlke; Laura J Scott; Erin C Peck; Pablo Hollstein; Andrew D Skol; Anne U Jackson; Panos Deloukas; Sarah Hunt; George Stavrides; Peter S Chines; Michael R Erdos; Narisu Narisu; Karen N Conneely; Chun Li; Tasha E Fingerlin; Sharanjeet K Dhanjal; Timo T Valle; Richard N Bergman; Jaakko Tuomilehto; Richard Watanabe; Michael Boehnke; Francis S Collins
Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.
Diabetes 2004;53(4):1141-9.
2003: Maria Eriksson; W Ted Brown; Leslie B Gordon; Michael W Glynn; Joel Singer; Laura Scott; Michael R Erdos; Christiane M Robbins; Tracy Y Moses; Peter Berglund; Amalia Dutra; Evgenia Pak; Sandra G Durkin; Antonei B Csoka; Michael Boehnke; Thomas W Glover; Francis S Collins
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.
Nature 2003;423(6937):293-8.
2002: Karen L Mohlke; Michael R Erdos; Laura J Scott; Tasha E Fingerlin; Anne U Jackson; Kaisa Silander; Pablo Hollstein; Michael Boehnke; Francis S Collins
High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16928-33.
2002: Tasha E Fingerlin; Michael R Erdos; Richard Watanabe; Kerry Wiles; Heather M Stringham; Karen L Mohlke; Kaisa Silander; Timo T Valle; Thomas A Buchanan; Jaakko Tuomilehto; Richard N Bergman; Michael Boehnke; Francis S Collins
Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort.
Diabetes 2002;51(5):1644-8.
2002: Saijun Fan; Yong Xian Ma; Chenguang Wang; Ren-Qi Yuan; Qinghui Meng; Ji-An Wang; Michael R Erdos; Itzhak D Goldberg; Paul Webb; Peter J Kushner; Richard G Pestell; Eliot M Rosen
p300 Modulates the BRCA1 inhibition of estrogen receptor activity.
Cancer research 2002;62(1):141-51.
2001: Saijun Fan; R Yuan; Yong Xian Ma; Jingbo Xiong; Qinghui Meng; Michael R Erdos; J N Zhao; Itzhak D Goldberg; Richard G Pestell; Eliot M Rosen
Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding.
Oncogene 2001;20(35):4827-41.
2001: Julie A Douglas; Michael R Erdos; Richard Watanabe; A Braun; C L Johnston; P Oeth; Karen L Mohlke; Timo T Valle; C Ehnholm; Thomas A Buchanan; Richard N Bergman; Francis S Collins; Michael Boehnke; Jaakko Tuomilehto
The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences.
Diabetes 2001;50(4):886-90.
2001: Saijun Fan; Yong Xian Ma; Chenguang Wang; Ren-Qi Yuan; Qinghui Meng; Ji-An Wang; Michael R Erdos; Itzhak D Goldberg; P Webb; Peter J Kushner; Richard G Pestell; Eliot M Rosen
Role of direct interaction in BRCA1 inhibition of estrogen receptor activity.
Oncogene 2001;20(1):77-87.
2000: S Ghosh; Richard Watanabe; Timo T Valle; Elizabeth R Hauser; Victoria L Magnuson; Carl D Langefeld; DS Ally; Karen L Mohlke; Kaisa Silander; K Kohtamäki; Peter S Chines; J Balow Jr; G Birznieks; J Chang; W Eldridge; Michael R Erdos; ZE Karanjawala; JI Knapp; K Kudelko; C Martin; A Morales-Mena; A Musick; T Musick; C Pfahl; R Porter; JB Rayman
The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes.
American journal of human genetics 2000;67(5):1174-85.
2000: Sharon Maor; Shirley Abramovitch; Michael R Erdos; Lawrence C Brody; Haim Werner
BRCA1 suppresses insulin-like growth factor-I receptor promoter activity: potential interaction between BRCA1 and Sp1.
Molecular genetics and metabolism 2000;69(2):130-6.
1999: Saijun Fan; J Wang; R Yuan; Y Ma; Qinghui Meng; Michael R Erdos; Richard G Pestell; Fang Yuan; Karen Auborn; Itzhak D Goldberg; Eliot M Rosen
BRCA1 inhibition of estrogen receptor signaling in transfected cells.
Science (New York, N.Y.) 1999;284(5418):1354-6.
1998: Saijun Fan; Ji-An Wang; Ren-Qi Yuan; Yong Xian Ma; Qinghui Meng; Michael R Erdos; Lawrence C Brody; Itzhak D Goldberg; Eliot M Rosen
BRCA1 as a potential human prostate tumor suppressor: modulation of proliferation, damage responses and expression of cell regulatory proteins.
Oncogene 1998;16(23):3069-82.
1998: Joseph G Hacia; W Makalowski; Keith Edgemon; Michael R Erdos; Christiane M Robbins; Steve Fodor; Lawrence C Brody; Francis S Collins
Evolutionary sequence comparisons using high-density oligonucleotide arrays.
Nature genetics 1998;18(2):155-8.
1997: Jeff Humphrey; A Salim; Michael R Erdos; Francis S Collins; Lawrence C Brody; Richard D Klausner
Human BRCA1 inhibits growth in yeast: potential use in diagnostic testing.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(11):5820-5.
1996: K J Abel; Lawrence C Brody; J M Valdes; Michael R Erdos; D R McKinley; Lucio H Castilla; Sofia D Merajver; Fergus J. Couch; L S Friedman; E A Ostermeyer; Eric D Lynch; Mary-Claire King; Piri Welcsh; S Osborne-Lawrence; M Spillman; Anne M Bowcock; Francis S Collins; Barbara L Weber
Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1.
Genomics 1996;37(2):161-71.
1996: E Schröck; P Badger; D Larson; Michael R Erdos; Anthony Wynshaw-Boris; Thomas Ried; Lawrence C Brody
The murine homolog of the human breast and ovarian cancer susceptibility gene Brca1 maps to mouse chromosome 11D.
Human genetics 1996;97(2):256-9.
1995: Jeffery Struewing; Lawrence C Brody; Michael R Erdos; R G Kase; T R Giambarresi; S A Smith; Francis S Collins; Margaret A Tucker
Detection of eight BRCA1 mutations in 10 breast/ovarian cancer families, including 1 family with male breast cancer.
American journal of human genetics 1995;57(1):1-7.
1994: Lucio H Castilla; Fergus J. Couch; Michael R Erdos; K F Hoskins; Kathleen A Calzone; Judy E Garber; J Boyd; M B Lubin; M L Deshano; Lawrence C Brody
Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer.
Nature genetics 1994;8(4):387-91.