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James Ervasti

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Chemicals & Drugs

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Protein Binding

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Antonio Filareto; Michelina Iacovino; Michael Kyba; Timothy Mayerhofer; R Scott McIvor; Sarah Parker; Luciene Borges; Jeffrey S Chamberlain; radbod darabi; James M Ervasti; Tory Schaaf; Rita C R Perlingeiro
An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells.
Ava Yun Lin; Ewa Prochniewicz; James M Ervasti; Davin M Henderson; Bin Li; David D Thomas
Impacts of dystrophin and utrophin domains on actin structural dynamics: implications for therapeutic design.
Davin M Henderson; Ava Yun Lin; David D Thomas; James M Ervasti
The carboxy-terminal third of dystrophin enhances actin binding activity.

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All Publications

2013: Antonio Filareto; Michelina Iacovino; Michael Kyba; Timothy Mayerhofer; R Scott McIvor; Sarah Parker; Luciene Borges; Jeffrey S Chamberlain; radbod darabi; James M Ervasti; Tory Schaaf; Rita C R Perlingeiro
An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells.
Nature communications 2013;4():1549.
2012: Ava Yun Lin; Ewa Prochniewicz; James M Ervasti; Davin M Henderson; Bin Li; David D Thomas
Impacts of dystrophin and utrophin domains on actin structural dynamics: implications for therapeutic design.
Journal of molecular biology 2012;420(1-2):87-98.
2012: Davin M Henderson; Ava Yun Lin; David D Thomas; James M Ervasti
The carboxy-terminal third of dystrophin enhances actin binding activity.
Journal of molecular biology 2012;416(3):414-24.
2012: Duan-Sun Zhang; David P Corey; James M Ervasti; Benjamin J Perrin; Valeria Piazza; J Collin Poczatek; Haydn M Prosser; Agnieszka K Rzadzinska; Mei Wang; Claude P Lechene
Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia.
Nature 2012;481(7382):520-4.
2012: Thomas R Cheever; Bin Li; James M Ervasti
Restricted morphological and behavioral abnormalities following ablation of β-actin in the brain.
PloS one 2012;7(3):e32970.
2011: Tina M Bunnell; Brandon J Burbach; Yoji Shimizu; James M Ervasti
β-Actin specifically controls cell growth, migration, and the G-actin pool.
Molecular biology of the cell 2011;22(21):4047-58.
2011: Davin M Henderson; Hanke Heun-Johnson; Bin Li; Joseph J Belanto; James M Ervasti
Internal deletion compromises the stability of dystrophin.
Human molecular genetics 2011;20(15):2955-63.
2011: Jarrod Call; James M Ervasti; Dawn A Lowe
TAT-μUtrophin mitigates the pathophysiology of dystrophin and utrophin double-knockout mice.
Journal of applied physiology (Bethesda, Md. : 1985) 2011;111(1):200-5.
2011: Kurt W Prins; Jarrod Call; Dawn A Lowe; James M Ervasti
Quadriceps myopathy caused by skeletal muscle-specific ablation of β(cyto)-actin.
Journal of cell science 2011;124(Pt 6):951-7.
2011: Tina M Bunnell; James M Ervasti
Structural and functional properties of the actin gene family.
Critical reviews in eukaryotic gene expression 2011;21(3):255-66.
2011: Kristen A Baltgalvis; Daniel P Fitzsimons; Michele A Jaeger; Dawn A Lowe; Stanley A Thayer; James M Ervasti
Transgenic overexpression of γ-cytoplasmic actin protects against eccentric contraction-induced force loss in mdx mice.
Skeletal muscle 2011;1(1):32.
2011: Thomas R Cheever; Emily A Olson; James M Ervasti
Axonal regeneration and neuronal function are preserved in motor neurons lacking ß-actin in vivo.
PloS one 2011;6(3):e17768.
2010: Benjamin J Perrin; Kevin J Sonnemann; James M Ervasti
β-actin and γ-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance.
PLoS genetics 2010;6(10):e1001158.
2010: Benjamin J Perrin; James M Ervasti
The actin gene family: function follows isoform.
Cytoskeleton (Hoboken, N.J.) 2010;67(10):630-4.
2010: Tina M Bunnell; James M Ervasti
Delayed embryonic development and impaired cell growth and survival in Actg1 null mice.
Cytoskeleton (Hoboken, N.J.) 2010;67(9):564-72.
2010: Davin M Henderson; Ann Lee; James M Ervasti
Disease-causing missense mutations in actin binding domain 1 of dystrophin induce thermodynamic instability and protein aggregation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(21):9632-7.
2009: Kurt W Prins; Jill L Humston; Amisha Mehta; Victoria Tate; Evelyn Ralston; James M Ervasti
Dystrophin is a microtubule-associated protein.
The Journal of cell biology 2009;186(3):363-9.
2009: Michele A Jaeger; Kevin J Sonnemann; Daniel P Fitzsimons; Kurt W Prins; James M Ervasti
Context-dependent functional substitution of alpha-skeletal actin by gamma-cytoplasmic actin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(7):2205-14.
2009: Kevin J Sonnemann; Hanke Heun-Johnson; Amy J Turner; Kristen A Baltgalvis; Dawn A Lowe; James M Ervasti
Functional substitution by TAT-utrophin in dystrophin-deficient mice.
PLoS medicine 2009;6(5):e1000083.
2009: Ewa Prochniewicz; Davin Henderson; James M Ervasti; David D Thomas
Dystrophin and utrophin have distinct effects on the structural dynamics of actin.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(19):7822-7.
2008: Tina M Bunnell; Michele A Jaeger; Daniel P Fitzsimons; Kurt W Prins; James M Ervasti
Destabilization of the dystrophin-glycoprotein complex without functional deficits in alpha-dystrobrevin null muscle.
PloS one 2008;3(7):e2604.
2008: Kurt W Prins; Dawn A Lowe; James M Ervasti
Skeletal muscle-specific ablation of gamma(cyto)-actin does not exacerbate the mdx phenotype.
PloS one 2008;3(6):e2419.
2008: James M Ervasti; Kevin J Sonnemann
Biology of the striated muscle dystrophin-glycoprotein complex.
International review of cytology 2008;265():191-225.
2007: Laurin M Hanft; Daniel J Bogan; Ulrike Mayer; Stephen J Kaufman; Joe Kornegay; James M Ervasti
Cytoplasmic gamma-actin expression in diverse animal models of muscular dystrophy.
Neuromuscular disorders : NMD 2007;17(7):569-74.
2007: David Harrison; Sadaf-Ahmahni Hussain; Ariana C Combs; James M Ervasti; Peter D Yurchenco; Erhard Hohenester
Crystal structure and cell surface anchorage sites of laminin alpha1LG4-5.
The Journal of biological chemistry 2007;282(15):11573-81.
2007: James M Ervasti
Dystrophin, its interactions with other proteins, and implications for muscular dystrophy.
Biochimica et biophysica acta 2007;1772(2):108-17.
2006: Kevin J Sonnemann; Daniel P Fitzsimons; Jitandrakumar R Patel; Yewei Liu; Martin F Schneider; Richard L Moss; James M Ervasti
Cytoplasmic gamma-actin is not required for skeletal muscle development but its absence leads to a progressive myopathy.
Developmental cell 2006;11(3):387-97.
2006: Erin L McDearmon; Ariana C Combs; Kiyotoshi Sekiguchi; Hironobu Fujiwara; James M Ervasti
Brain alpha-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11.
FEBS letters 2006;580(14):3381-5.
2006: Inna N Rybakova; Jill L Humston; Kevin J Sonnemann; James M Ervasti
Dystrophin and utrophin bind actin through distinct modes of contact.
The Journal of biological chemistry 2006;281(15):9996-10001.
2006: Laurin M Hanft; Inna N Rybakova; Jitandrakumar R Patel; Jill A Rafael-Fortney; James M Ervasti
Cytoplasmic gamma-actin contributes to a compensatory remodeling response in dystrophin-deficient muscle.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(14):5385-90.
2005: Ariana C Combs; James M Ervasti
Enhanced laminin binding by alpha-dystroglycan after enzymatic deglycosylation.
The Biochemical journal 2005;390(Pt 1):303-9.
2005: Inna N Rybakova; James M Ervasti
Identification of spectrin-like repeats required for high affinity utrophin-actin interaction.
The Journal of biological chemistry 2005;280(24):23018-23.
2004: Hiroyuki Ido; Kenji Harada; Sugiko Futaki; Yoshitaka Hayashi; Ryoko Nishiuchi; Yuko Natsuka; Shaoliang Li; Yoshinao Wada; Ariana C Combs; James M Ervasti; Kiyotoshi Sekiguchi
Molecular dissection of the alpha-dystroglycan- and integrin-binding sites within the globular domain of human laminin-10.
The Journal of biological chemistry 2004;279(12):10946-54.
2003: Erin L McDearmon; Ariana C Combs; James M Ervasti
Core 1 glycans on alpha-dystroglycan mediate laminin-induced acetylcholine receptor clustering but not laminin binding.
The Journal of biological chemistry 2003;278(45):44868-73.
2003: James M Ervasti
Costameres: the Achilles' heel of Herculean muscle.
The Journal of biological chemistry 2003;278(16):13591-4.
2002: Sergei P Smirnov; Erin L McDearmon; Shaohua Li; James M Ervasti; Karl Tryggvason; Peter D Yurchenco
Contributions of the LG modules and furin processing to laminin-2 functions.
The Journal of biological chemistry 2002;277(21):18928-37.
2002: Inna N Rybakova; Jitandrakumar R Patel; Kay E Davies; Peter D Yurchenco; James M Ervasti
Utrophin binds laterally along actin filaments and can couple costameric actin with sarcolemma when overexpressed in dystrophin-deficient muscle.
Molecular biology of the cell 2002;13(5):1512-21.
2002: Laura E Warner; Christiana DelloRusso; Robert W Crawford; Inna N Rybakova; Jitandrakumar R Patel; James M Ervasti; Jeffrey S Chamberlain
Expression of Dp260 in muscle tethers the actin cytoskeleton to the dystrophin-glycoprotein complex and partially prevents dystrophy.
Human molecular genetics 2002;11(9):1095-105.
2002: Vitold E Galkin; Albina Orlova; Margaret S VanLoock; Inna N Rybakova; James M Ervasti; Edward H Egelman
The utrophin actin-binding domain binds F-actin in two different modes: implications for the spectrin superfamily of proteins.
The Journal of cell biology 2002;157(2):243-51.
2001: Erin L McDearmon; Ariana C Combs; James M Ervasti
Differential Vicia villosa agglutinin reactivity identifies three distinct dystroglycan complexes in skeletal muscle.
The Journal of biological chemistry 2001;276(37):35078-86.
2001: Albina Orlova; Inna N Rybakova; E Prochniewicz; David D Thomas; James M Ervasti; Edward H Egelman
Binding of dystrophin's tandem calponin homology domain to F-actin is modulated by actin's structure.
Biophysical journal 2001;80(4):1926-31.
2000: Inna N Rybakova; Jitandrakumar R Patel; James M Ervasti
The dystrophin complex forms a mechanically strong link between the sarcolemma and costameric actin.
The Journal of cell biology 2000;150(5):1209-14.
1999: Kurt Amann; A W Guo; James M Ervasti
Utrophin lacks the rod domain actin binding activity of dystrophin.
The Journal of biological chemistry 1999;274(50):35375-80.
1998: Kurt Amann; BA Renley; James M Ervasti
A cluster of basic repeats in the dystrophin rod domain binds F-actin through an electrostatic interaction.
The Journal of biological chemistry 1998;273(43):28419-23.
1998: Erin L McDearmon; A L Burwell; Ariana C Combs; BA Renley; M T Sdano; James M Ervasti
Differential heparin sensitivity of alpha-dystroglycan binding to laminins expressed in normal and dy/dy mouse skeletal muscle.
The Journal of biological chemistry 1998;273(37):24139-44.
1998: BA Renley; Inna N Rybakova; Kurt Amann; James M Ervasti
Dystrophin binding to nonmuscle actin.
Cell motility and the cytoskeleton 1998;41(3):264-70.
1997: Inna N Rybakova; James M Ervasti
Dystrophin-glycoprotein complex is monomeric and stabilizes actin filaments in vitro through a lateral association.
The Journal of biological chemistry 1997;272(45):28771-8.
1997: James M Ervasti; A L Burwell; Aimee Geissler
Tissue-specific heterogeneity in alpha-dystroglycan sialoglycosylation. Skeletal muscle alpha-dystroglycan is a latent receptor for Vicia villosa agglutinin b4 masked by sialic acid modification.
The Journal of biological chemistry 1997;272(35):22315-21.
1997: James M Ervasti; Inna N Rybakova; Kurt Amann
A multiple site, side binding model for the interaction of dystrophin with F-actin.
Society of General Physiologists series 1997;52():31-44.
1996: Inna N Rybakova; Kurt Amann; James M Ervasti
A new model for the interaction of dystrophin with F-actin.
The Journal of cell biology 1996;135(3):661-72.
1996: J E Hagstrom; Inna N Rybakova; T Staeva; J A Wolff; James M Ervasti
Nonnuclear DNA binding proteins in striated muscle.
Biochemical and molecular medicine 1996;58(1):113-21.
1996: E A Pall; K M Bolton; James M Ervasti
Differential heparin inhibition of skeletal muscle alpha-dystroglycan binding to laminins.
The Journal of biological chemistry 1996;271(7):3817-21.
1994: James M Ervasti; S L Roberds; R D Anderson; Nicholas J H Sharp; Joe Kornegay; Kevin P Campbell
Alpha-dystroglycan deficiency correlates with elevated serum creatine kinase and decreased muscle contraction tension in golden retriever muscular dystrophy.
FEBS letters 1994;350(2-3):173-6.
1993: K Matsumura; Fernando M S Tomé; V Ionasescu; James M Ervasti; R D Anderson; Norma B Romero; D Simon; D Récan; Jean-Claude Kaplan; M Fardeau
Deficiency of dystrophin-associated proteins in Duchenne muscular dystrophy patients lacking COOH-terminal domains of dystrophin.
The Journal of clinical investigation 1993;92(2):866-71.
1993: James M Ervasti; Kevin P Campbell
A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin.
The Journal of cell biology 1993;122(4):809-23.
1993: S L Roberds; James M Ervasti; R D Anderson; Kay Ohlendieck; Steven D Kahl; D Zoloto; Kevin P Campbell
Disruption of the dystrophin-glycoprotein complex in the cardiomyopathic hamster.
The Journal of biological chemistry 1993;268(16):11496-9.
1993: James M Ervasti; Kevin P Campbell
Dystrophin-associated glycoproteins: their possible roles in the pathogenesis of Duchenne muscular dystrophy.
Molecular and cell biology of human diseases series 1993;3():139-66.
1992: K Matsumura; James M Ervasti; Kay Ohlendieck; Steven D Kahl; Kevin P Campbell
Association of dystrophin-related protein with dystrophin-associated proteins in mdx mouse muscle.
Nature 1992;360(6404):588-91.
1992: O Ibraghimov-Beskrovnaya; James M Ervasti; C J Leveille; C A Slaughter; S W Sernett; Kevin P Campbell
Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix.
Nature 1992;355(6362):696-702.
1991: James M Ervasti; Kevin P Campbell
Membrane organization of the dystrophin-glycoprotein complex.
Cell 1991;66(6):1121-31.
1991: Kay Ohlendieck; James M Ervasti; K Matsumura; Steven D Kahl; C J Leveille; Kevin P Campbell
Dystrophin-related protein is localized to neuromuscular junctions of adult skeletal muscle.
Neuron 1991;7(3):499-508.
1991: James M Ervasti; Steven D Kahl; Kevin P Campbell
Purification of dystrophin from skeletal muscle.
The Journal of biological chemistry 1991;266(14):9161-5.
1991: Kay Ohlendieck; James M Ervasti; J B Snook; Kevin P Campbell
Dystrophin-glycoprotein complex is highly enriched in isolated skeletal muscle sarcolemma.
The Journal of cell biology 1991;112(1):135-48.
1990: James M Ervasti; Kay Ohlendieck; Steven D Kahl; M G Gaver; Kevin P Campbell
Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle.
Nature 1990;345(6273):315-9.