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Jorge Escalante-Semerena

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Hannah F Collins; Jorge C Escalante-Semerena; Michael Gray; Helen K Leech; Kirsty J McLean; Andrew W Munro; Stephen E J Rigby; Martin J Warren; Rebekka Biedendieck; Andrew D Lawrence
Bacillus megaterium has both a functional BluB protein required for DMB synthesis and a related flavoprotein that forms a stable radical species.
Alex C Tucker; Jorge C Escalante-Semerena
Acetoacetyl-CoA synthetase activity is controlled by a protein acetyltransferase with unique domain organization in Streptomyces lividans.
Theodore C Moore; Sean A Newmister; Ivan Rayment; Jorge C Escalante-Semerena
Structural insights into the mechanism of four-coordinate Cob(II)alamin formation in the active site of the Salmonella enterica ATP:Co(I)rrinoid adenosyltransferase enzyme: critical role of residues Phe91 and Trp93.

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2013: Hannah F Collins; Jorge C Escalante-Semerena; Michael Gray; Helen K Leech; Kirsty J McLean; Andrew W Munro; Stephen E J Rigby; Martin J Warren; Rebekka Biedendieck; Andrew D Lawrence
Bacillus megaterium has both a functional BluB protein required for DMB synthesis and a related flavoprotein that forms a stable radical species.
PloS one 2013;8(2):e55708.
2013: Alex C Tucker; Jorge C Escalante-Semerena
Acetoacetyl-CoA synthetase activity is controlled by a protein acetyltransferase with unique domain organization in Streptomyces lividans.
Molecular microbiology 2013;87(1):152-67.
2012: Theodore C Moore; Sean A Newmister; Ivan Rayment; Jorge C Escalante-Semerena
Structural insights into the mechanism of four-coordinate Cob(II)alamin formation in the active site of the Salmonella enterica ATP:Co(I)rrinoid adenosyltransferase enzyme: critical role of residues Phe91 and Trp93.
Biochemistry 2012;51(48):9647-57.
2012: Heidi A Crosby; Katherine C Rank; Ivan Rayment; Jorge C Escalante-Semerena
Structural insights into the substrate specificity of the Rhodopseudomonas palustris protein acetyltransferase RpPat: identification of a loop critical for recognition by RpPat.
The Journal of biological chemistry 2012;287(49):41392-404.
2012: Sean A Newmister; Chi Ho Chan; Jorge C Escalante-Semerena; Ivan Rayment
Structural insights into the function of the nicotinate mononucleotide:phenol/p-cresol phosphoribosyltransferase (ArsAB) enzyme from Sporomusa ovata.
Biochemistry 2012;51(43):8571-82.
2012: Heidi A Crosby; Katherine C Rank; Ivan Rayment; Jorge C Escalante-Semerena
Structure-guided expansion of the substrate range of methylmalonyl coenzyme A synthetase (MatB) of Rhodopseudomonas palustris.
Applied and environmental microbiology 2012;78(18):6619-29.
2012: Sandy Thao; Jorge C Escalante-Semerena
A positive selection approach identifies residues important for folding of Salmonella enterica Pat, an N(ε)-lysine acetyltransferase that regulates central metabolism enzymes.
Research in microbiology 2012;163(6-7):427-35.
2012: Heidi A Crosby; Gregory B Hurst; Dale A Pelletier; Jorge C Escalante-Semerena
System-wide studies of N-lysine acetylation in Rhodopseudomonas palustris reveal substrate specificity of protein acetyltransferases.
The Journal of biological chemistry 2012;287(19):15590-601.
2012: Tara N Stuecker; Kelsey M Hodge; Jorge C Escalante-Semerena
The missing link in coenzyme A biosynthesis: PanM (formerly YhhK), a yeast GCN5 acetyltransferase homologue triggers aspartate decarboxylase (PanD) maturation in Salmonella enterica.
Molecular microbiology 2012;84(4):608-19.
2012: Kiyoung Park; Jorge C Escalante-Semerena; Paola E Mera; Thomas C Brunold
Spectroscopic characterization of active-site variants of the PduO-type ATP:corrinoid adenosyltransferase from Lactobacillus reuteri: insights into the mechanism of four-coordinate Co(II)corrinoid formation.
Inorganic chemistry 2012;51(8):4482-94.
2012: Tara N Stuecker; Alex C Tucker; Jorge C Escalante-Semerena
PanM, an acetyl-coenzyme A sensor required for maturation of L-aspartate decarboxylase (PanD).
mBio 2012;3(4):.
2011: Chi Ho Chan; Jorge C Escalante-Semerena
ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for adenosylcobamide biosynthesis.
Molecular microbiology 2011;81(4):952-67.
2011: Sean A Newmister; Michele M Otte; Jorge C Escalante-Semerena; Ivan Rayment
Structure and mutational analysis of the archaeal GTP:AdoCbi-P guanylyltransferase (CobY) from Methanocaldococcus jannaschii: insights into GTP binding and dimerization.
Biochemistry 2011;50(23):5301-13.
2011: Chi Ho Chan; Jane Garrity; Heidi A Crosby; Jorge C Escalante-Semerena
In Salmonella enterica, the sirtuin-dependent protein acylation/deacylation system (SDPADS) maintains energy homeostasis during growth on low concentrations of acetate.
Molecular microbiology 2011;80(1):168-83.
2011: Sandy Thao; Jorge C Escalante-Semerena
Control of protein function by reversible Nɛ-lysine acetylation in bacteria.
Current opinion in microbiology 2011;14(2):200-4.
2011: Sandy Thao; Jorge C Escalante-Semerena
Biochemical and thermodynamic analyses of Salmonella enterica Pat, a multidomain, multimeric N(ε)-lysine acetyltransferase involved in carbon and energy metabolism.
mBio 2011;2(5):.
2011: Poonam Bheda; Jennifer T Wang; Jorge C Escalante-Semerena; Cynthia Wolberger
Structure of Sir2Tm bound to a propionylated peptide.
Protein science : a publication of the Protein Society 2011;20(1):131-9.
2010: Alex C Tucker; Jorge C Escalante-Semerena
Biologically active isoforms of CobB sirtuin deacetylase in Salmonella enterica and Erwinia amylovora.
Journal of bacteriology 2010;192(23):6200-8.
2010: Paola E Mera; Jorge C Escalante-Semerena
Multiple roles of ATP:cob(I)alamin adenosyltransferases in the conversion of B12 to coenzyme B12.
Applied microbiology and biotechnology 2010;88(1):41-8.
2010: Michael J Gray; Jorge C Escalante-Semerena
A new pathway for the synthesis of α-ribazole-phosphate in Listeria innocua.
Molecular microbiology 2010;77(6):1429-38.
2010: Heidi A Crosby; Erin K Heiniger; Caroline S Harwood; Jorge C Escalante-Semerena
Reversible N epsilon-lysine acetylation regulates the activity of acyl-CoA synthetases involved in anaerobic benzoate catabolism in Rhodopseudomonas palustris.
Molecular microbiology 2010;76(4):874-88.
2010: Christopher J Rocco; Jorge C Escalante-Semerena
In Salmonella enterica, 2-methylcitrate blocks gluconeogenesis.
Journal of bacteriology 2010;192(3):771-8.
2010: Paola E Mera; Jorge C Escalante-Semerena
Dihydroflavin-driven adenosylation of 4-coordinate Co(II) corrinoids: are cobalamin reductases enzymes or electron transfer proteins?
The Journal of biological chemistry 2010;285(5):2911-7.
2010: Sandy Thao; Chien-Sheng Chen; Heng Zhu; Jorge C Escalante-Semerena
Nε-lysine acetylation of a bacterial transcription factor inhibits Its DNA-binding activity.
PloS one 2010;5(12):e15123.
2010: Kathy R Claas; J R Parrish; Lori A Maggio-Hall; Jorge C Escalante-Semerena
Functional analysis of the nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) enzyme, involved in the late steps of coenzyme B12 biosynthesis in Salmonella enterica.
Journal of bacteriology 2010;192(1):145-54.
2009: Michael J Gray; Jorge C Escalante-Semerena
The cobinamide amidohydrolase (cobyric acid-forming) CbiZ enzyme: a critical activity of the cobamide remodelling system of Rhodobacter sphaeroides.
Molecular microbiology 2009;74(5):1198-210.
2009: Michele M Otte; Jorge C Escalante-Semerena
Biochemical characterization of the GTP:adenosylcobinamide-phosphate guanylyltransferase (CobY) enzyme of the hyperthermophilic archaeon Methanocaldococcus jannaschii.
Biochemistry 2009;48(25):5882-9.
2009: Michael J Gray; Jorge C Escalante-Semerena
In vivo analysis of cobinamide salvaging in Rhodobacter sphaeroides strain 2.4.1.
Journal of bacteriology 2009;191(12):3842-51.
2009: Paola E Mera; Martin St Maurice; Ivan Rayment; Jorge C Escalante-Semerena
Residue Phe112 of the human-type corrinoid adenosyltransferase (PduO) enzyme of Lactobacillus reuteri is critical to the formation of the four-coordinate Co(II) corrinoid substrate and to the activity of the enzyme.
Biochemistry 2009;48(14):3138-45.
2009: Jeffrey A Lewis; Lisa W Stamper; Jorge C Escalante-Semerena
Regulation of expression of the tricarballylate utilization operon (tcuABC) of Salmonella enterica.
Research in microbiology 2009;160(3):179-86.
2009: Jeffrey A Lewis; Jeffrey M Boyd; Diana Marie Downs; Jorge C Escalante-Semerena
Involvement of the Cra global regulatory protein in the expression of the iscRSUA operon, revealed during studies of tricarballylate catabolism in Salmonella enterica.
Journal of bacteriology 2009;191(7):2069-76.
2009: Jeffrey G Gardner; Jorge C Escalante-Semerena
In Bacillus subtilis, the sirtuin protein deacetylase, encoded by the srtN gene (formerly yhdZ), and functions encoded by the acuABC genes control the activity of acetyl coenzyme A synthetase.
Journal of bacteriology 2009;191(6):1749-55.
2008: Michael J Gray; Norbert K Tavares; Jorge C Escalante-Semerena
The genome of Rhodobacter sphaeroides strain 2.4.1 encodes functional cobinamide salvaging systems of archaeal and bacterial origins.
Molecular microbiology 2008;70(4):824-36.
2008: Kiyoung Park; Paola E Mera; Jorge C Escalante-Semerena; Thomas C Brunold
Kinetic and spectroscopic studies of the ATP:corrinoid adenosyltransferase PduO from Lactobacillus reuteri: substrate specificity and insights into the mechanism of Co(II)corrinoid reduction.
Biochemistry 2008;47(34):9007-15.
2008: Jeffrey G Gardner; Jorge C Escalante-Semerena
Biochemical and mutational analyses of AcuA, the acetyltransferase enzyme that controls the activity of the acetyl coenzyme a synthetase (AcsA) in Bacillus subtilis.
Journal of bacteriology 2008;190(14):5132-6.
2008: Jeffrey M Boyd; Jeffrey A Lewis; Jorge C Escalante-Semerena; Diana Marie Downs
Salmonella enterica requires ApbC function for growth on tricarballylate: evidence of functional redundancy between ApbC and IscU.
Journal of bacteriology 2008;190(13):4596-602.
2008: Martin St Maurice; Paola Mera; Kiyoung Park; Thomas C Brunold; Jorge C Escalante-Semerena; Ivan Rayment
Structural characterization of a human-type corrinoid adenosyltransferase confirms that coenzyme B12 is synthesized through a four-coordinate intermediate.
Biochemistry 2008;47(21):5755-66.
2008: C J Rocco; K L Dennison; Vadim A Klenchin; Ivan Rayment; Jorge C Escalante-Semerena
Construction and use of new cloning vectors for the rapid isolation of recombinant proteins from Escherichia coli.
Plasmid 2008;59(3):231-7.
2008: Pilar Ruiz-Sánchez; Stefan Mundwiler; Bernhard Spingler; Nicole R Buan; Jorge C Escalante-Semerena; Roger Alberto
Syntheses and characterization of vitamin B12-Pt(II) conjugates and their adenosylation in an enzymatic assay.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2008;13(3):335-47.
2007: Paola E Mera; Martin St Maurice; Ivan Rayment; Jorge C Escalante-Semerena
Structural and functional analyses of the human-type corrinoid adenosyltransferase (PduO) from Lactobacillus reuteri.
Biochemistry 2007;46(48):13829-36.
2007: Carmen L Zayas; Kathy R Claas; Jorge C Escalante-Semerena
The CbiB protein of Salmonella enterica is an integral membrane protein involved in the last step of the de novo corrin ring biosynthetic pathway.
Journal of bacteriology 2007;189(21):7697-708.
2007: Jane Garrity; Jeffrey G Gardner; William Hawse; Cynthia Wolberger; Jorge C Escalante-Semerena
N-lysine propionylation controls the activity of propionyl-CoA synthetase.
The Journal of biological chemistry 2007;282(41):30239-45.
2007: Michele M Otte; Jesse D Woodson; Jorge C Escalante-Semerena
The thiamine kinase (YcfN) enzyme plays a minor but significant role in cobinamide salvaging in Salmonella enterica.
Journal of bacteriology 2007;189(20):7310-5.
2007: Jeffrey A Lewis; Jorge C Escalante-Semerena
Tricarballylate catabolism in Salmonella enterica. The TcuB protein uses 4Fe-4S clusters and heme to transfer electrons from FADH2 in the tricarballylate dehydrogenase (TcuA) enzyme to electron acceptors in the cell membrane.
Biochemistry 2007;46(31):9107-15.
2007: Graeme Garvey; Christopher J Rocco; Jorge C Escalante-Semerena; Ivan Rayment
The three-dimensional crystal structure of the PrpF protein of Shewanella oneidensis complexed with trans-aconitate: insights into its biological function.
Protein science : a publication of the Protein Society 2007;16(7):1274-84.
2007: Jorge C Escalante-Semerena
Conversion of cobinamide into adenosylcobamide in bacteria and archaea.
Journal of bacteriology 2007;189(13):4555-60.
2007: Shaun R Brinsmade; Jorge C Escalante-Semerena
In vivo and in vitro analyses of single-amino acid variants of the Salmonella enterica phosphotransacetylase enzyme provide insights into the function of its N-terminal domain.
The Journal of biological chemistry 2007;282(17):12629-40.
2007: Carmen L Zayas; Jorge C Escalante-Semerena
Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway.
Journal of bacteriology 2007;189(6):2210-8.
2007: Michael J Gray; Jorge C Escalante-Semerena
Single-enzyme conversion of FMNH2 to 5,6-dimethylbenzimidazole, the lower ligand of B12.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2921-6.
2007: Martin St Maurice; Paola E Mera; María Pía Taranto; Fernando Sesma; Jorge C Escalante-Semerena; Ivan Rayment
Structural characterization of the active site of the PduO-type ATP:Co(I)rrinoid adenosyltransferase from Lactobacillus reuteri.
The Journal of biological chemistry 2007;282(4):2596-605.
2006: Jeffrey A Lewis; Jorge C Escalante-Semerena
The FAD-dependent tricarballylate dehydrogenase (TcuA) enzyme of Salmonella enterica converts tricarballylate into cis-aconitate.
Journal of bacteriology 2006;188(15):5479-86.
2006: Jeffrey G Gardner; Frank J Grundy; Tina M Henkin; Jorge C Escalante-Semerena
Control of acetyl-coenzyme A synthetase (AcsA) activity by acetylation/deacetylation without NAD(+) involvement in Bacillus subtilis.
Journal of bacteriology 2006;188(15):5460-8.
2006: Nicole R Buan; Jorge C Escalante-Semerena
Purification and initial biochemical characterization of ATP:Cob(I)alamin adenosyltransferase (EutT) enzyme of Salmonella enterica.
The Journal of biological chemistry 2006;281(25):16971-7.
2006: Jesse D Woodson; Jorge C Escalante-Semerena
The cbiS gene of the archaeon Methanopyrus kandleri AV19 encodes a bifunctional enzyme with adenosylcobinamide amidohydrolase and alpha-ribazole-phosphate phosphatase activities.
Journal of bacteriology 2006;188(12):4227-35.
2006: Nicole R Buan; Kimberly Rehfeld; Jorge C Escalante-Semerena
Studies of the CobA-type ATP:Co(I)rrinoid adenosyltransferase enzyme of Methanosarcina mazei strain Go1.
Journal of bacteriology 2006;188(10):3543-50.
2006: Yang Re Kim; Shaun R Brinsmade; Zheng Yang; Jorge C Escalante-Semerena; Joshua Fierer
Mutation of phosphotransacetylase but not isocitrate lyase reduces the virulence of Salmonella enterica serovar Typhimurium in mice.
Infection and immunity 2006;74(4):2498-502.
2006: Carmen L Zayas; Jesse D Woodson; Jorge C Escalante-Semerena
The cobZ gene of Methanosarcina mazei Go1 encodes the nonorthologous replacement of the alpha-ribazole-5'-phosphate phosphatase (CobC) enzyme of Salmonella enterica.
Journal of bacteriology 2006;188(7):2740-3.
2005: Nicole R Buan; Jorge C Escalante-Semerena
Computer-assisted docking of flavodoxin with the ATP:Co(I)rrinoid adenosyltransferase (CobA) enzyme reveals residues critical for protein-protein interactions but not for catalysis.
The Journal of biological chemistry 2005;280(49):40948-56.
2005: Shaun R Brinsmade; Tenzin Paldon; Jorge C Escalante-Semerena
Minimal functions and physiological conditions required for growth of salmonella enterica on ethanolamine in the absence of the metabolosome.
Journal of bacteriology 2005;187(23):8039-46.
2005: Vincent Starai; Jane Garrity; Jorge C Escalante-Semerena
Acetate excretion during growth of Salmonella enterica on ethanolamine requires phosphotransacetylase (EutD) activity, and acetate recapture requires acetyl-CoA synthetase (Acs) and phosphotransacetylase (Pta) activities.
Microbiology (Reading, England) 2005;151(Pt 11):3793-801.
2005: Jesse D Woodson; April A Reynolds; Jorge C Escalante-Semerena
ABC transporter for corrinoids in Halobacterium sp. strain NRC-1.
Journal of bacteriology 2005;187(17):5901-9.
2005: Vincent Starai; Jeffrey G Gardner; Jorge C Escalante-Semerena
Residue Leu-641 of Acetyl-CoA synthetase is critical for the acetylation of residue Lys-609 by the Protein acetyltransferase enzyme of Salmonella enterica.
The Journal of biological chemistry 2005;280(28):26200-5.
2005: Troy A Stich; Nicole R Buan; Jorge C Escalante-Semerena; Thomas C Brunold
Spectroscopic and computational studies of the ATP:corrinoid adenosyltransferase (CobA) from Salmonella enterica: insights into the mechanism of adenosylcobalamin biosynthesis.
Journal of the American Chemical Society 2005;127(24):8710-9.
2004: Sergio Palacios; Jorge C Escalante-Semerena
2-Methylcitrate-dependent activation of the propionate catabolic operon (prpBCDE) of Salmonella enterica by the PrpR protein.
Microbiology (Reading, England) 2004;150(Pt 11):3877-87.
2004: Nicole R Buan; Sang-Jin Suh; Jorge C Escalante-Semerena
The eutT gene of Salmonella enterica Encodes an oxygen-labile, metal-containing ATP:corrinoid adenosyltransferase enzyme.
Journal of bacteriology 2004;186(17):5708-14.
2004: Vincent Starai; Jorge C Escalante-Semerena
Acetyl-coenzyme A synthetase (AMP forming).
Cellular and molecular life sciences : CMLS 2004;61(16):2020-30.
2004: Vincent Starai; Jorge C Escalante-Semerena
Identification of the protein acetyltransferase (Pat) enzyme that acetylates acetyl-CoA synthetase in Salmonella enterica.
Journal of molecular biology 2004;340(5):1005-12.
2004: Lori A Maggio-Hall; Kathy R Claas; Jorge C Escalante-Semerena
The last step in coenzyme B(12) synthesis is localized to the cell membrane in bacteria and archaea.
Microbiology (Reading, England) 2004;150(Pt 5):1385-95.
2004: Vincent Starai; H Takahashi; Jef Boeke; Jorge C Escalante-Semerena
A link between transcription and intermediary metabolism: a role for Sir2 in the control of acetyl-coenzyme A synthetase.
Current opinion in microbiology 2004;7(2):115-9.
2004: Jesse D Woodson; Jorge C Escalante-Semerena
CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12 precursor cobinamide in archaea.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3591-6.
2004: Shaun R Brinsmade; Jorge C Escalante-Semerena
The eutD gene of Salmonella enterica encodes a protein with phosphotransacetylase enzyme activity.
Journal of bacteriology 2004;186(6):1890-2.
2004: Jeffrey A Lewis; Alexander R Horswill; Brian E Schwem; Jorge C Escalante-Semerena
The Tricarballylate utilization (tcuRABC) genes of Salmonella enterica serovar Typhimurium LT2.
Journal of bacteriology 2004;186(6):1629-37.
2004: Tracey L Grimek; Jorge C Escalante-Semerena
The acnD genes of Shewenella oneidensis and Vibrio cholerae encode a new Fe/S-dependent 2-methylcitrate dehydratase enzyme that requires prpF function in vivo.
Journal of bacteriology 2004;186(2):454-62.
2003: Jesse D Woodson; Carmen L Zayas; Jorge C Escalante-Semerena
A new pathway for salvaging the coenzyme B12 precursor cobinamide in archaea requires cobinamide-phosphate synthase (CbiB) enzyme activity.
Journal of bacteriology 2003;185(24):7193-201.
2003: T L Grimek; H Holden; Ivan Rayment; Jorge C Escalante-Semerena
Residues C123 and D58 of the 2-methylisocitrate lyase (PrpB) enzyme of Salmonella enterica are essential for catalysis.
Journal of bacteriology 2003;185(16):4837-43.
2003: Lori A Maggio-Hall; Pieter dorrestein; Jorge C Escalante-Semerena; Tadhg P Begley
Formation of the dimethylbenzimidazole ligand of coenzyme B(12) under physiological conditions by a facile oxidative cascade.
Organic letters 2003;5(13):2211-3.
2003: Sergio Palacios; Vincent Starai; Jorge C Escalante-Semerena
Propionyl coenzyme A is a common intermediate in the 1,2-propanediol and propionate catabolic pathways needed for expression of the prpBCDE operon during growth of Salmonella enterica on 1,2-propanediol.
Journal of bacteriology 2003;185(9):2802-10.
2003: Lori A Maggio-Hall; Jorge C Escalante-Semerena
Alpha-5,6-dimethylbenzimidazole adenine dinucleotide (alpha-DAD), a putative new intermediate of coenzyme B12 biosynthesis in Salmonella typhimurium.
Microbiology (Reading, England) 2003;149(Pt 4):983-90.
2003: Andrew Gulick; Vincent Starai; Alexander R Horswill; Kristen M Homick; Jorge C Escalante-Semerena
The 1.75 A crystal structure of acetyl-CoA synthetase bound to adenosine-5'-propylphosphate and coenzyme A.
Biochemistry 2003;42(10):2866-73.
2003: Vincent Starai; Hidekazu Takahashi; Jef Boeke; Jorge C Escalante-Semerena
Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae.
Genetics 2003;163(2):545-55.
2003: Jesse D Woodson; Ronald Peck; Mark P Krebs; Jorge C Escalante-Semerena
The cobY gene of the archaeon Halobacterium sp. strain NRC-1 is required for de novo cobamide synthesis.
Journal of bacteriology 2003;185(1):311-6.
2002: Vincent Starai; Ivana Celic; Robert N Cole; Jef Boeke; Jorge C Escalante-Semerena
Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine.
Science (New York, N.Y.) 2002;298(5602):2390-2.
2002: Cheom-Gil Cheong; Jorge C Escalante-Semerena; Ivan Rayment
Capture of a labile substrate by expulsion of water molecules from the active site of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella enterica.
The Journal of biological chemistry 2002;277(43):41120-7.
2002: Maris V Fonseca; Nicole R Buan; Alexander R Horswill; Ivan Rayment; Jorge C Escalante-Semerena
The ATP:Co(I)rrinoid adenosyltransferase (CobA) enzyme of Salmonella enterica requires the 2'-OH group of ATP for function and yields inorganic triphosphate as its reaction byproduct.
The Journal of biological chemistry 2002;277(36):33127-31.
2002: Martin J Warren; Evelyne Raux; Heidi L Schubert; Jorge C Escalante-Semerena
The biosynthesis of adenosylcobalamin (vitamin B12).
Natural product reports 2002;19(4):390-412.
2002: Cheom-Gil Cheong; Jorge C Escalante-Semerena; Ivan Rayment
Structural studies of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica: the apo, substrate, and product-aldimine complexes.
Biochemistry 2002;41(29):9079-89.
2002: Cheom-Gil Cheong; Cay Brian Bauer; Kevin R Brushaber; Jorge C Escalante-Semerena; Ivan Rayment
Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica.
Biochemistry 2002;41(15):4798-808.
2002: Alexander R Horswill; Jorge C Escalante-Semerena
Characterization of the propionyl-CoA synthetase (PrpE) enzyme of Salmonella enterica: residue Lys592 is required for propionyl-AMP synthesis.
Biochemistry 2002;41(7):2379-87.
2002: Andrew Gulick; Alexander R Horswill; James B Thoden; Jorge C Escalante-Semerena; Ivan Rayment
Pentaerythritol propoxylate: a new crystallization agent and cryoprotectant induces crystal growth of 2-methylcitrate dehydratase.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 2):306-9.
2001: Cheom-Gil Cheong; Jorge C Escalante-Semerena; Ivan Rayment
Structural investigation of the biosynthesis of alternative lower ligands for cobamides by nicotinate mononucleotide: 5,6-dimethylbenzimidazole phosphoribosyltransferase from Salmonella enterica.
The Journal of biological chemistry 2001;276(40):37612-20.
2001: Maris V Fonseca; Jorge C Escalante-Semerena
An in vitro reducing system for the enzymic conversion of cobalamin to adenosylcobalamin.
The Journal of biological chemistry 2001;276(34):32101-8.
2001: Alexander R Horswill; A R Dudding; Jorge C Escalante-Semerena
Studies of propionate toxicity in Salmonella enterica identify 2-methylcitrate as a potent inhibitor of cell growth.
The Journal of biological chemistry 2001;276(22):19094-101.
2001: Alexander R Horswill; Jorge C Escalante-Semerena
In vitro conversion of propionate to pyruvate by Salmonella enterica enzymes: 2-methylcitrate dehydratase (PrpD) and aconitase Enzymes catalyze the conversion of 2-methylcitrate to 2-methylisocitrate.
Biochemistry 2001;40(15):4703-13.
2001: Cay Brian Bauer; Maris V Fonseca; Hazel M Holden; James B Thoden; Thomas B Thompson; Jorge C Escalante-Semerena; Ivan Rayment
Three-dimensional structure of ATP:corrinoid adenosyltransferase from Salmonella typhimurium in its free state, complexed with MgATP, or complexed with hydroxycobalamin and MgATP.
Biochemistry 2001;40(2):361-74.
2000: M G Thomas; Thomas B Thompson; Ivan Rayment; Jorge C Escalante-Semerena
Analysis of the adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase (CobU) enzyme of Salmonella typhimurium LT2. Identification of residue His-46 as the site of guanylylation.
The Journal of biological chemistry 2000;275(36):27576-86.
2000: Maris V Fonseca; Jorge C Escalante-Semerena
Reduction of Cob(III)alamin to Cob(II)alamin in Salmonella enterica serovar typhimurium LT2.
Journal of bacteriology 2000;182(15):4304-9.
2000: Michael G Thomas; Jorge C Escalante-Semerena
Identification of an alternative nucleoside triphosphate: 5'-deoxyadenosylcobinamide phosphate nucleotidyltransferase in Methanobacterium thermoautotrophicum delta H.
Journal of bacteriology 2000;182(15):4227-33.
2000: Jeffrey S Smith; CB Brachmann; Ivana Celic; M A Kenna; Shabazz Muhammad; Vincent Starai; José L Avalos; Jorge C Escalante-Semerena; C Grubmeyer; Cynthia Wolberger; Jef Boeke
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6658-63.
2000: Sergio Palacios; Jorge C Escalante-Semerena
prpR, ntrA, and ihf functions are required for expression of the prpBCDE operon, encoding enzymes that catabolize propionate in Salmonella enterica serovar typhimurium LT2.
Journal of bacteriology 2000;182(4):905-10.
1999: C G Cheong; Jorge C Escalante-Semerena; Ivan Rayment
The three-dimensional structures of nicotinate mononucleotide:5,6- dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella typhimurium complexed with 5,6-dimethybenzimidazole and its reaction products determined to 1.9 A resolution.
Biochemistry 1999;38(49):16125-35.
1999: Lori A Maggio-Hall; Jorge C Escalante-Semerena
In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11798-803.
1999: Thomas B Thompson; M G Thomas; Jorge C Escalante-Semerena; Ivan Rayment
Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase (CobU) complexed with GMP: evidence for a substrate-induced transferase active site.
Biochemistry 1999;38(40):12995-3005.
1999: Alexander R Horswill; Jorge C Escalante-Semerena
Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle.
Journal of bacteriology 1999;181(18):5615-23.
1999: Alexander R Horswill; Jorge C Escalante-Semerena
The prpE gene of Salmonella typhimurium LT2 encodes propionyl-CoA synthetase.
Microbiology (Reading, England) 1999;145 ( Pt 6)():1381-8.
1999: Michael G Thomas; G A O'Toole; Jorge C Escalante-Semerena
Molecular characterization of eutF mutants of Salmonella typhimurium LT2 identifies eutF lesions as partial-loss-of-function tonB alleles.
Journal of bacteriology 1999;181(2):368-74.
1998: A W Tsang; Alexander R Horswill; Jorge C Escalante-Semerena
Studies of regulation of expression of the propionate (prpBCDE) operon provide insights into how Salmonella typhimurium LT2 integrates its 1,2-propanediol and propionate catabolic pathways.
Journal of bacteriology 1998;180(24):6511-8.
1998: Michelle R Rondon; Jorge C Escalante-Semerena
High levels of transcription factor RpoS (sigma S) in mviA mutants negatively affect 1,2-propanediol-dependent transcription of the cob/pdu regulon of Salmonella typhimurium LT2.
FEMS microbiology letters 1998;169(1):147-53.
1998: A W Tsang; Jorge C Escalante-Semerena
CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis in Salmonella typhimurium LT2.
The Journal of biological chemistry 1998;273(48):31788-94.
1998: Thomas B Thompson; M G Thomas; Jorge C Escalante-Semerena; Ivan Rayment
Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase from Salmonella typhimurium determined to 2.3 A resolution,.
Biochemistry 1998;37(21):7686-95.
1998: K R Brushaber; G A O'Toole; Jorge C Escalante-Semerena
CobD, a novel enzyme with L-threonine-O-3-phosphate decarboxylase activity, is responsible for the synthesis of (R)-1-amino-2-propanol O-2-phosphate, a proposed new intermediate in cobalamin biosynthesis in Salmonella typhimurium LT2.
The Journal of biological chemistry 1998;273(5):2684-91.
1997: J R Trzebiatowski; Jorge C Escalante-Semerena
Purification and characterization of CobT, the nicotinate-mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase enzyme from Salmonella typhimurium LT2.
The Journal of biological chemistry 1997;272(28):17662-7.
1997: Michelle R Rondon; Jorge C Escalante-Semerena
Integration host factor is required for 1,2-propanediol-dependent transcription of the cob/pdu regulon in Salmonella typhimurium LT2.
Journal of bacteriology 1997;179(11):3797-800.
1997: Alexander R Horswill; Jorge C Escalante-Semerena
Propionate catabolism in Salmonella typhimurium LT2: two divergently transcribed units comprise the prp locus at 8.5 centisomes, prpR encodes a member of the sigma-54 family of activators, and the prpBCDE genes constitute an operon.
Journal of bacteriology 1997;179(3):928-40.
1997: Michelle R Rondon; J R Trzebiatowski; Jorge C Escalante-Semerena
Biochemistry and molecular genetics of cobalamin biosynthesis.
Progress in nucleic acid research and molecular biology 1997;56():347-84.
1996: A W Tsang; Jorge C Escalante-Semerena
cobB function is required for catabolism of propionate in Salmonella typhimurium LT2: evidence for existence of a substitute function for CobB within the 1,2-propanediol utilization (pdu) operon.
Journal of bacteriology 1996;178(23):7016-9.
1996: T A Hammelman; G A O'Toole; J R Trzebiatowski; A W Tsang; D Rank; Jorge C Escalante-Semerena
Identification of a new prp locus required for propionate catabolism in Salmonella typhimurium LT2.
FEMS microbiology letters 1996;137(2-3):233-9.
1996: Michelle R Rondon; Jorge C Escalante-Semerena
In vitro analysis of the interactions between the PocR regulatory protein and the promoter region of the cobalamin biosynthetic (cob) operon of Salmonella typhimurium LT2.
Journal of bacteriology 1996;178(8):2196-203.
1995: Michelle R Rondon; Alexander R Horswill; Jorge C Escalante-Semerena
DNA polymerase I function is required for the utilization of ethanolamine, 1,2-propanediol, and propionate by Salmonella typhimurium LT2.
Journal of bacteriology 1995;177(24):7119-24.
1995: G A O'Toole; Jorge C Escalante-Semerena
Purification and characterization of the bifunctional CobU enzyme of Salmonella typhimurium LT2. Evidence for a CobU-GMP intermediate.
The Journal of biological chemistry 1995;270(40):23560-9.
1995: Michelle R Rondon; R Kazmierczak; Jorge C Escalante-Semerena
Glutathione is required for maximal transcription of the cobalamin biosynthetic and 1,2-propanediol utilization (cob/pdu) regulon and for the catabolism of ethanolamine, 1,2-propanediol, and propionate in Salmonella typhimurium LT2.
Journal of bacteriology 1995;177(19):5434-9.
1995: S Suh; Jorge C Escalante-Semerena
Purification and initial characterization of the ATP:corrinoid adenosyltransferase encoded by the cobA gene of Salmonella typhimurium.
Journal of bacteriology 1995;177(4):921-5.
1994: G A O'Toole; J R Trzebiatowski; Jorge C Escalante-Semerena
The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin.
The Journal of biological chemistry 1994;269(42):26503-11.
1994: J R Trzebiatowski; G A O'Toole; Jorge C Escalante-Semerena
The cobT gene of Salmonella typhimurium encodes the NaMN: 5,6-dimethylbenzimidazole phosphoribosyltransferase responsible for the synthesis of N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole, an intermediate in the synthesis of the nucleotide loop of cobalamin.
Journal of bacteriology 1994;176(12):3568-75.
1993: G A O'Toole; Jorge C Escalante-Semerena
cobU-dependent assimilation of nonadenosylated cobinamide in cobA mutants of Salmonella typhimurium.
Journal of bacteriology 1993;175(19):6328-36.
1993: S J Suh; Jorge C Escalante-Semerena
Cloning, sequencing and overexpression of cobA which encodes ATP:corrinoid adenosyltransferase in Salmonella typhimurium.
Gene 1993;129(1):93-7.
1993: G A O'Toole; Michelle R Rondon; Jorge C Escalante-Semerena
Analysis of mutants of Salmonella typhimurium defective in the synthesis of the nucleotide loop of cobalamin.
Journal of bacteriology 1993;175(11):3317-26.
1992: M G Johnson; Jorge C Escalante-Semerena
Identification of 5,6-dimethylbenzimidazole as the Co alpha ligand of the cobamide synthesized by Salmonella typhimurium. Nutritional characterization of mutants defective in biosynthesis of the imidazole ring.
The Journal of biological chemistry 1992;267(19):13302-5.
1992: Michelle R Rondon; Jorge C Escalante-Semerena
The poc locus is required for 1,2-propanediol-dependent transcription of the cobalamin biosynthetic (cob) and propanediol utilization (pdu) genes of Salmonella typhimurium.
Journal of bacteriology 1992;174(7):2267-72.
1992: Jorge C Escalante-Semerena; M G Johnson; J R Roth
The CobII and CobIII regions of the cobalamin (vitamin B12) biosynthetic operon of Salmonella typhimurium.
Journal of bacteriology 1992;174(1):24-9.
1991: G A O'Toole; Jorge C Escalante-Semerena
Identification and initial characterization of the eutF locus of Salmonella typhimurium.
Journal of bacteriology 1991;173(16):5168-72.
1990: Jorge C Escalante-Semerena; S J Suh; J R Roth
cobA function is required for both de novo cobalamin biosynthesis and assimilation of exogenous corrinoids in Salmonella typhimurium.
Journal of bacteriology 1990;172(1):273-80.