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Denis Escande

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Frank S Choveau; Nicolas Rodriguez; Alain J Labro; Thierry Rose; Shehrazade Dahimène; Hélène Boudin; Carole Le Hénaff; Denis Escande; Dirk J Snyders; Flavien Charpentier; Jean Mérot; Isabelle Baro; Fayal Abderemane Ali; Gildas Loussouarn
KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.
Nathalie Gaborit; Andras Varro; Sabrina Le Bouter; Viktoria Szuts; Denis Escande; Stanley Nattel; Sophie Demolombe
Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts.
Anne-Laure Leoni; Bruno Gavillet; Jean-Sébastien Rougier; Céline Marionneau; Vincent Probst; Solena Le Scouarnec; Jean-Jacques Schott; Sophie Demolombe; Patrick Bruneval; Christopher L-H Huang; William H Colledge; Andrew A Grace; Hervé Le Marec; Arthur A Wilde; Peter J Mohler; Denis Escande; Hugues Abriel; Flavien Charpentier
Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model.

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All Publications

2011: Frank S Choveau; Nicolas Rodriguez; Alain J Labro; Thierry Rose; Shehrazade Dahimène; Hélène Boudin; Carole Le Hénaff; Denis Escande; Dirk J Snyders; Flavien Charpentier; Jean Mérot; Isabelle Baro; Fayal Abderemane Ali; Gildas Loussouarn
KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.
The Journal of biological chemistry 2011;286(1):707-16.
2010: Nathalie Gaborit; Andras Varro; Sabrina Le Bouter; Viktoria Szuts; Denis Escande; Stanley Nattel; Sophie Demolombe
Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts.
Journal of molecular and cellular cardiology 2010;49(4):639-46.
2010: Anne-Laure Leoni; Bruno Gavillet; Jean-Sébastien Rougier; Céline Marionneau; Vincent Probst; Solena Le Scouarnec; Jean-Jacques Schott; Sophie Demolombe; Patrick Bruneval; Christopher L-H Huang; William H Colledge; Andrew A Grace; Hervé Le Marec; Arthur A Wilde; Peter J Mohler; Denis Escande; Hugues Abriel; Flavien Charpentier
Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model.
PloS one 2010;5(2):e9298.
2009: Carol Ann Remme; Brendon P Scicluna; Arie O Verkerk; Ahmad S Amin; Sandra van Brunschot; Leander Beekman; Vera H M Deneer; Catherine Chevalier; Fumitaka Oyama; Haruko Miyazaki; Nobuyuki Nukina; Ronald Wilders; Denis Escande; Rémi Houlgatte; Arthur A M Wilde; Hanno L Tan; Marieke W Veldkamp; Jacques M T de Bakker; Connie R Bezzina
Genetically determined differences in sodium current characteristics modulate conduction disease severity in mice with cardiac sodium channelopathy.
Circulation research 2009;104(11):1283-92.
2009: Nathalie Gaborit; Thomas Wichter; Andras Varro; Viktoria Szuts; guillaume lamirault; Lars Eckardt; Matthias Paul; Günter Breithardt; Eric Schulze-Bahr; Denis Escande; Stanley Nattel; Sophie Demolombe
Transcriptional profiling of ion channel genes in Brugada syndrome and other right ventricular arrhythmogenic diseases.
European heart journal 2009;30(4):487-96.
2008: Julien Piron; Khai Le Quang; François Briec; Jean-Christophe Amirault; Anne-Laure Leoni; Léa Desigaux; Denis Escande; Bruno Pitard; Flavien Charpentier
Biological pacemaker engineered by nonviral gene transfer in a mouse model of complete atrioventricular block.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(12):1937-43.
2008: Céline S Nicolas; Kyu-Ho Park; Aziza El Harchi; Jacques Camonis; Robert Kass; Denis Escande; Jean Mérot; Gildas Loussouarn; Françoise Le Bouffant; Isabelle Baro
IKs response to protein kinase A-dependent KCNQ1 phosphorylation requires direct interaction with microtubules.
Cardiovascular research 2008;79(3):427-35.
2007: Nathalie Gaborit; Sabrina Le Bouter; Viktoria Szuts; Andras Varro; Denis Escande; Stanley Nattel; Sophie Demolombe
Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart.
The Journal of physiology 2007;582(Pt 2):675-93.
2007: Peter J Mohler; Solena Le Scouarnec; Isabelle Denjoy; John S Lowe; Pascale Guicheney; Lise Caron; Iwona M Driskell; Jean-Jacques Schott; Keith C Norris; Antoine Leenhardt; Richard B Kim; Denis Escande; Dan Mark Roden
Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes.
Circulation 2007;115(4):432-41.
2006: Shehrazade Dahimène; Sébastien Alcoléa; Patrice Naud; Philippe Jourdon; Denis Escande; Robert Brasseur; Annick Thomas; Isabelle Baro; Jean Mérot
The N-terminal juxtamembranous domain of KCNQ1 is critical for channel surface expression: implications in the Romano-Ward LQT1 syndrome.
Circulation research 2006;99(10):1076-83.
2006: Marie Allouis; Françoise Le Bouffant; Ronald Wilders; David Péroz; Jean-Jacques Schott; Jacques Noireaud; Hervé Le Marec; Jean Mérot; Denis Escande; Isabelle Baro
14-3-3 is a regulator of the cardiac voltage-gated sodium channel Nav1.5.
Circulation research 2006;98(12):1538-46.
2006: Matteo E Mangoni; Achraf Traboulsie; Anne-Laure Leoni; Brigitte Couette; Laurine Marger; Khai Le Quang; Elodie Kupfer; Anne Cohen-Solal; José Vilar; Hee-Sup Shin; Denis Escande; Flavien Charpentier; Joël Nargeot; Philippe Lory
Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels.
Circulation research 2006;98(11):1422-30.
2006: Vincent Probst; Marie Allouis; Frédéric Sacher; Sabine Pattier; Dominique Babuty; Philippe Mabo; Jacques Mansourati; Jacques Victor; Jean-Michel Nguyen; Jean-Jacques Schott; Pierre Boisseau; Denis Escande; Hervé Le Marec
Progressive cardiac conduction defect is the prevailing phenotype in carriers of a Brugada syndrome SCN5A mutation.
Journal of cardiovascular electrophysiology 2006;17(3):270-5.
2006: Gildas Loussouarn; Isabelle Baro; Denis Escande
KCNQ1 K+ channel-mediated cardiac channelopathies.
Methods in molecular biology (Clifton, N.J.) 2006;337():167-83.
2006: guillaume lamirault; Nathalie Gaborit; Nolwenn Le Meur; Catherine Chevalier; Gilles Lande; Sophie Demolombe; Denis Escande; Stanley Nattel; Jean J Léger; Marja Steenman
Gene expression profile associated with chronic atrial fibrillation and underlying valvular heart disease in man.
Journal of molecular and cellular cardiology 2006;40(1):173-84.
2005: Anne-Laure Leoni; Céline Marionneau; Sophie Demolombe; Sabrina Le Bouter; Matteo E Mangoni; Denis Escande; Flavien Charpentier
Chronic heart rate reduction remodels ion channel transcripts in the mouse sinoatrial node but not in the ventricle.
Physiological genomics 2005;24(1):4-12.
2005: Toon A B van Veen; Mera Stein; Anne Royer; Khai Le Quang; Flavien Charpentier; William H Colledge; Christopher L-H Huang; Ronald Wilders; Andrew A Grace; Denis Escande; Jacques M T de Bakker; Harold V M van Rijen
Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging.
Circulation 2005;112(13):1927-35.
2005: Saïd Bendahhou; Céline Marionneau; Karinne Haurogne; Marie-Madeleine Larroque; Renaud Derand; Viktoria Szuts; Denis Escande; Sophie Demolombe; Jacques Barhanin
In vitro molecular interactions and distribution of KCNE family with KCNQ1 in the human heart.
Cardiovascular research 2005;67(3):529-38.
2005: Sophie Demolombe; Céline Marionneau; Sabrina Le Bouter; Flavien Charpentier; Denis Escande
Functional genomics of cardiac ion channel genes.
Cardiovascular research 2005;67(3):438-47.
2005: Nathalie Gaborit; Marja Steenman; guillaume lamirault; Nolwenn Le Meur; Sabrina Le Bouter; Gilles Lande; Jean Léger; Flavien Charpentier; Torsten Christ; Dobromir Dobrev; Denis Escande; Stanley Nattel; Sophie Demolombe
Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation.
Circulation 2005;112(4):471-81.
2005: Léa Desigaux; Clothilde Gourden; Mahajoub Bello-Roufaï; Peggy Richard; Noufissa Oudrhiri; Pierre Lehn; Denis Escande; Hélène Pollard; Bruno Pitard
Nonionic amphiphilic block copolymers promote gene transfer to the lung.
Human gene therapy 2005;16(7):821-9.
2005: Kyu-Ho Park; Julien Piron; Shehrazade Dahimene; Jean Mérot; Isabelle Baro; Denis Escande; Gildas Loussouarn
Impaired KCNQ1-KCNE1 and phosphatidylinositol-4,5-bisphosphate interaction underlies the long QT syndrome.
Circulation research 2005;96(7):730-9.
2005: Anne Royer; Toon A B van Veen; Sabrina Le Bouter; Céline Marionneau; Violaine Griol-Charhbili; Anne-Laure Léoni; Marja Steenman; Harold V M van Rijen; Sophie Demolombe; Catharine Goddard; Christine Richer; Brigitte Escoubet; Thérèse Jarry-Guichard; William H Colledge; Daniel Gros; Jacques M T de Bakker; Andrew A Grace; Denis Escande; Flavien Charpentier
Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis.
Circulation 2005;111(14):1738-46.
2005: Marja Steenman; guillaume lamirault; Nolwenn Le Meur; Martine Le Cunff; Denis Escande; Jean J Léger
Distinct molecular portraits of human failing hearts identified by dedicated cDNA microarrays.
European journal of heart failure 2005;7(2):157-65.
2005: Anne Royer; Sophie Demolombe; Aziza El Harchi; Khai Le Quang; Julien Piron; Gilles Toumaniantz; David Mazurais; Chloé Bellocq; Gilles Lande; Cecile Terrenoire; Howard K Motoike; Jean-Christophe Chevallier; Gildas Loussouarn; colleen clancy; Denis Escande; Flavien Charpentier
Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity.
Cardiovascular research 2005;65(1):128-37.
2005: Céline Marionneau; Brigitte Couette; Jie Liu; Huiyu Li; Matteo E Mangoni; Joël Nargeot; Ming Lei; Denis Escande; Sophie Demolombe
Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart.
The Journal of physiology 2005;562(Pt 1):223-34.
2005: Peggy Richard; Hélène Pollard; Caroline Lanctin; Mahajoub Bello-Roufaï; Léa Désigaux; Denis Escande; Bruno Pitard
Inducible production of erythropoietin using intramuscular injection of block copolymer/DNA formulation.
The journal of gene medicine 2005;7(1):80-6.
2004: Sabrina Le Bouter; Aziza El Harchi; Céline Marionneau; Chloé Bellocq; Arnaud Chambellan; Toon A B van Veen; Christophe Boixel; Bruno Gavillet; Hugues Abriel; Khai Le Quang; Jean-Christophe Chevalier; Gilles Lande; Jean J Léger; Flavien Charpentier; Denis Escande; Sophie Demolombe
Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart.
Circulation 2004;110(19):3028-35.
2004: Chloé Bellocq; Ronald Wilders; Jean-Jacques Schott; Bénédicte Louérat-Oriou; Pierre Boisseau; Hervé Le Marec; Denis Escande; Isabelle Baro
A common antitussive drug, clobutinol, precipitates the long QT syndrome 2.
Molecular pharmacology 2004;66(5):1093-102.
2004: Chloé Bellocq; Antoni C G van Ginneken; Connie R Bezzina; Marielle Alders; Denis Escande; marcel mannens; Isabelle Baro; Arthur A M Wilde
Mutation in the KCNQ1 gene leading to the short QT-interval syndrome.
Circulation 2004;109(20):2394-7.
2004: Bruno Pitard; Mahajoub Bello-Roufaï; Olivier Lambert; Peggy Richard; Léa Desigaux; sarah fernandes; Caroline Lanctin; Hélène Pollard; Mehdi Zeghal; Pierre-Yves Rescan; Denis Escande
Negatively charged self-assembling DNA/poloxamine nanospheres for in vivo gene transfer.
Nucleic acids research 2004;32(20):e159.
2004: Flavien Charpentier; Sophie Demolombe; Denis Escande
Cardiac channelopathies: from men to mice.
Annals of medicine 2004;36 Suppl 1():28-34.
2003: Gilles Guihard; Chloé Bellocq; E Grelet; Denis Escande
Human Kv1.6 current displays a C-type-like inactivation when re-expressed in cos-7 cells.
Biochemical and biophysical research communications 2003;311(1):83-9.
2003: Gildas Loussouarn; K-H Park; Chloé Bellocq; Isabelle Baro; Flavien Charpentier; Denis Escande
Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels.
The EMBO journal 2003;22(20):5412-21.
2003: Lucas J Herfst; Franck Potet; Connie R Bezzina; W Antoinette Groenewegen; Hervé Le Marec; Theo M Hoorntje; Sophie Demolombe; Isabelle Baro; Denis Escande; Habo J Jongsma; Arthur A M Wilde; Martin B Rook
Na+ channel mutation leading to loss of function and non-progressive cardiac conduction defects.
Journal of molecular and cellular cardiology 2003;35(5):549-57.
2003: Vincent Probst; Florence Kyndt; Franck Potet; Jean-Noël Trochu; Guy Mialet; Sophie Demolombe; Jean-Jacques Schott; Isabelle Baro; Denis Escande; Hervé Le Marec
Haploinsufficiency in combination with aging causes SCN5A-linked hereditary Lenègre disease.
Journal of the American College of Cardiology 2003;41(4):643-52.
2003: Sabrina Le Bouter; Sophie Demolombe; Arnaud Chambellan; Chloé Bellocq; Franck Aimond; Gilles Toumaniantz; Gilles Lande; Sepideh Siavoshian; Isabelle Baro; Amber L Pond; Jeanne M Nerbonne; Jean J Léger; Denis Escande; Flavien Charpentier
Microarray analysis reveals complex remodeling of cardiac ion channel expression with altered thyroid status: relation to cellular and integrated electrophysiology.
Circulation research 2003;92(2):234-42.
2003: Peter J Mohler; Jean-Jacques Schott; Anthony O Gramolini; Keith Dilly; Silvia Guatimosim; William H duBell; Long-Sheng Song; Karine Haurogné; Florence Kyndt; Mervat E Ali; Terry B Rogers; William Lederer; Denis Escande; Hervé Le Marec; Vann Bennett
Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death.
Nature 2003;421(6923):634-9.
2003: Franck Potet; Philippe Mabo; Guillaume Le Coq; Vincent Probst; Jean-Jacques Schott; Fabrice Airaud; Gilles Guihard; Jean-Claude Daubert; Denis Escande; Hervé Le Marec
Novel brugada SCN5A mutation leading to ST segment elevation in the inferior or the right precordial leads.
Journal of cardiovascular electrophysiology 2003;14(2):200-3.
2002: Bruno Pitard; Hélène Pollard; Onnik Agbulut; Olivier Lambert; Jean-Thomas Vilquin; Yan Cherel; Jérôme Abadie; Jane-Lise Samuel; Jean-Louis Rigaud; Severine Menoret; Ignacio Anegon; Denis Escande
A nonionic amphiphile agent promotes gene delivery in vivo to skeletal and cardiac muscles.
Human gene therapy 2002;13(14):1767-75.
2002: Jeroen P P Smits; Lars Eckardt; Vincent Probst; Connie R Bezzina; Jean-Jacques Schott; Carol Ann Remme; Wilhelm Haverkamp; Günter Breithardt; Denis Escande; Eric Schulze-Bahr; Herve LeMarec; Arthur A M Wilde
Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients.
Journal of the American College of Cardiology 2002;40(2):350-6.
2001: Florence Kyndt; Vincent Probst; Franck Potet; Sophie Demolombe; J C Chevallier; Isabelle Baro; J P Moisan; Pierre Boisseau; Jean-Jacques Schott; Denis Escande; Hervé Le Marec
Novel SCN5A mutation leading either to isolated cardiac conduction defect or Brugada syndrome in a large French family.
Circulation 2001;104(25):3081-6.
2001: Franck Potet; T Bouyssou; Denis Escande; Isabelle Baro
Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-à-gogo K(+) channel.
The Journal of pharmacology and experimental therapeutics 2001;299(3):1007-12.
2001: Diego Franco; Sophie Demolombe; Sabina Kupershmidt; R Dumaine; J N Dominguez; Dan Mark Roden; Charles Antzelevitch; Denis Escande; Antoon F M Moorman
Divergent expression of delayed rectifier K(+) channel subunits during mouse heart development.
Cardiovascular research 2001;52(1):65-75.
2001: DF Riochet; R Mohammad-Panah; Steven C Hebert; Gordon G MacGregor; Isabelle Baro; Gilles Guihard; Denis Escande
Inactivating properties of recombinant ROMK2 channels expressed in mammalian cells.
Biochemical and biophysical research communications 2001;286(2):376-80.
2001: I Danner; Denis Escande; Chantal Gauthier
Beta(3)-adrenoceptors control Cl(-) conductance in rabbit nasal epithelium.
European journal of pharmacology 2001;422(1-3):203-7.
2001: Gilles Lande; Sophie Demolombe; A Bammert; A Moorman; Flavien Charpentier; Denis Escande
Transgenic mice overexpressing human KvLQT1 dominant-negative isoform. Part II: Pharmacological profile.
Cardiovascular research 2001;50(2):328-34.
2001: Sophie Demolombe; Gilles Lande; Flavien Charpentier; M A van Roon; M J van den Hoff; Gilles Toumaniantz; Isabelle Baro; Gilles Guihard; N Le Berre; A Corbier; Jacques M T de Bakker; T Opthof; Arthur Wilde; A F Moorman; Denis Escande
Transgenic mice overexpressing human KvLQT1 dominant-negative isoform. Part I: Phenotypic characterisation.
Cardiovascular research 2001;50(2):314-27.
2001: Franck Potet; John D Scott; R Mohammad-Panah; Denis Escande; Isabelle Baro
AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex.
American journal of physiology. Heart and circulatory physiology 2001;280(5):H2038-45.
2001: D Chabannes; Jacques Barhanin; Denis Escande
Mice disrupted for the KvLQT1 potassium channel regulator IsK gene accumulate mature T cells.
Cellular immunology 2001;209(1):1-9.
2001: H Pollard; Gilles Toumaniantz; J L Amos; H Avet-Loiseau; Gilles Guihard; Jean-Paul Behr; Denis Escande
Ca2+-sensitive cytosolic nucleases prevent efficient delivery to the nucleus of injected plasmids.
The journal of gene medicine 2001;3(2):153-64.
2001: Gilles Lande; Florence Kyndt; Isabelle Baro; D Chabannes; Pierre Boisseau; J C Pony; Denis Escande; Hervé Le Marec
Dynamic analysis of the QT interval in long QT1 syndrome patients with a normal phenotype.
European heart journal 2001;22(5):410-22.
2001: Gilles Lande; D Dudouet; Denis Escande
Measurement of potassium concentration in salivary and sweat fluids as a screening test for the long QT1 syndrome.
International journal of cardiology 2001;77(2-3):323-4.
2001: Sophie Demolombe; Diego Franco; P de Boer; S Kuperschmidt; Dan Mark Roden; Yann Péréon; A Jarry; Antoon F M Moorman; Denis Escande
Differential expression of KvLQT1 and its regulator IsK in mouse epithelia.
American journal of physiology. Cell physiology 2001;280(2):C359-72.
2000: Denis Escande
Pharmacogenetics of cardiac K(+) channels.
European journal of pharmacology 2000;410(2-3):281-287.
2000: Gilles Guihard; Sonia Proteau; Marcel D Payet; Denis Escande; Eric Rousseau
Patch-clamp study of liver nuclear ionic channels reconstituted into giant proteoliposomes.
FEBS letters 2000;476(3):234-9.
2000: Yann Péréon; Sophie Demolombe; Isabelle Baro; E Drouin; Flavien Charpentier; Denis Escande
Differential expression of KvLQT1 isoforms across the human ventricular wall.
American journal of physiology. Heart and circulatory physiology 2000;278(6):H1908-15.
2000: Gilles Lande; Christian Funck-Brentano; M Ghadanfar; Denis Escande
Steady-state versus non-steady-state QT-RR relationships in 24-hour Holter recordings.
Pacing and clinical electrophysiology : PACE 2000;23(3):293-302.
1999: Jean-Jacques Schott; C Alshinawi; Florence Kyndt; Vincent Probst; Theo M Hoorntje; M Hulsbeek; Arthur A M Wilde; Denis Escande; marcel mannens; Hervé Le Marec
Cardiac conduction defects associate with mutations in SCN5A.
Nature genetics 1999;23(1):20-1.
1999: Chantal Gauthier; Geneviève Tavernier; Jean-Noël Trochu; Véronique Leblais; K Laurent; Dominique Langin; Denis Escande; Hervé Le Marec
Interspecies differences in the cardiac negative inotropic effects of beta(3)-adrenoceptor agonists.
The Journal of pharmacology and experimental therapeutics 1999;290(2):687-93.
1999: I Danner; Pierre Boisseau; E Chailleux; Denis Escande
Respiratory epithelial ion transport in patients with disseminated bronchiectasis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;13(6):1276-80.
1999: R Mohammad-Panah; Sophie Demolombe; N Neyroud; Pascale Guicheney; Florence Kyndt; M van den Hoff; Isabelle Baro; Denis Escande
Mutations in a dominant-negative isoform correlate with phenotype in inherited cardiac arrhythmias.
American journal of human genetics 1999;64(4):1015-23.
1999: Véronique Leblais; Sophie Demolombe; G Vallette; Dominique Langin; Isabelle Baro; Denis Escande; Chantal Gauthier
beta3-adrenoceptor control the cystic fibrosis transmembrane conductance regulator through a cAMP/protein kinase A-independent pathway.
The Journal of biological chemistry 1999;274(10):6107-13.
1998: Flavien Charpentier; J Merot; DF Riochet; Hervé Le Marec; Denis Escande
Adult KCNE1-knockout mice exhibit a mild cardiac cellular phenotype.
Biochemical and biophysical research communications 1998;251(3):806-10.
1998: H Pollard; J S Remy; Gildas Loussouarn; Sophie Demolombe; Jean-Paul Behr; Denis Escande
Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells.
The Journal of biological chemistry 1998;273(13):7507-11.
1998: Sophie Demolombe; Isabelle Baro; Yann Péréon; Jet Bliek; R Mohammad-Panah; H Pollard; S Morid; marcel mannens; Arthur Wilde; Jacques Barhanin; Flavien Charpentier; Denis Escande
A dominant negative isoform of the long QT syndrome 1 gene product.
The Journal of biological chemistry 1998;273(12):6837-43.
1998: R Mohammad-Panah; Sophie Demolombe; DF Riochet; Véronique Leblais; Gildas Loussouarn; H Pollard; Isabelle Baro; Denis Escande
Hyperexpression of recombinant CFTR in heterologous cells alters its physiological properties.
The American journal of physiology 1998;274(2 Pt 1):C310-8.
1997: Gildas Loussouarn; Flavien Charpentier; R Mohammad-Panah; K Kunzelmann; Isabelle Baro; Denis Escande
KvLQT1 potassium channel but not IsK is the molecular target for trans-6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethyl- chromane.
Molecular pharmacology 1997;52(6):1131-6.
1996: P Henry; A Popescu; M Pucéat; M E Hinescu; Denis Escande
Acute simulated ischaemia produces both inhibition and activation of K+ currents in isolated ventricular myocytes.
Cardiovascular research 1996;32(5):930-9.
1996: Gildas Loussouarn; Sophie Demolombe; R Mohammad-Panah; Denis Escande; Isabelle Baro
Expression of CFTR controls cAMP-dependent activation of epithelial K+ currents.
The American journal of physiology 1996;271(5 Pt 1):C1565-73.
1996: Sophie Demolombe; Denis Escande
ATP-binding cassette proteins as targets for drug discovery.
Trends in pharmacological sciences 1996;17(8):273-5.
1996: P Henry; Sophie Demolombe; M Pucéat; Denis Escande
Adenosine A1 stimulation activates delta-protein kinase C in rat ventricular myocytes.
Circulation research 1996;78(1):161-5.
1995: B Roch; Isabelle Baro; A S Hongre; Denis Escande
ATP-sensitive K+ channels regulated by intracellular Ca2+ and phosphorylation in normal (T84) and cystic fibrosis (CFPAC-1) epithelial cells.
Pflügers Archiv : European journal of physiology 1995;429(3):355-63.
1994: F Besançon; G Przewlocki; Isabelle Baro; A S Hongre; Denis Escande; Aleksander Edelman
Interferon-gamma downregulates CFTR gene expression in epithelial cells.
The American journal of physiology 1994;267(5 Pt 1):C1398-404.
1994: Sophie Demolombe; Isabelle Baro; M Laurent; A S Hongre; A Pavirani; Denis Escande
Abnormal subcellular localization of mutated CFTR protein in a cystic fibrosis epithelial cell line.
European journal of cell biology 1994;65(1):214-9.
1994: Isabelle Baro; B Roch; A S Hongre; Denis Escande
Concomitant activation of Cl- and K+ currents by secretory stimulation in human epithelial cells.
The Journal of physiology 1994;478 Pt 3():469-82.
1994: P Henry; Denis Escande
Do potassium channel openers compete with ATP to activate ATP sensitive potassium channels?
Cardiovascular research 1994;28(6):754-9.
1994: A S Hongre; Isabelle Baro; B Berthon; Denis Escande
Effects of sulphonylureas on cAMP-stimulated Cl- transport via the cystic fibrosis gene product in human epithelial cells.
Pflügers Archiv : European journal of physiology 1994;426(3-4):284-7.
1994: J P Beregi; Denis Escande; N Coudray; Denis Chemla; M Mestre; N Péry; Yves Lecarpentier
[Positive inotropic and lusitropic effect of RP 62719, a new class III antiarrhythmia agent].
Archives des maladies du coeur et des vaisseaux 1994;87(2):263-9.
1993: Evelyne Benoit; Denis Escande
Fast K channels are more sensitive to riluzole than slow K channels in myelinated nerve fibre.
Pflügers Archiv : European journal of physiology 1993;422(5):536-8.
1992: J P Beregi; Denis Escande; N Coudray; P Mery; M Mestre; Denis Chemla; Yves Lecarpentier
Positive inotropic effects of RP 62719, a new pure class III antiarrhythmic agent, on guinea pig myocardium.
The Journal of pharmacology and experimental therapeutics 1992;263(3):1369-76.
1992: Denis Escande; I Cavero
K+ channel openers and 'natural' cardioprotection.
Trends in pharmacological sciences 1992;13(7):269-72.
1992: D Thuringer; P Lauribe; Denis Escande
A hyperpolarization-activated inward current in human myocardial cells.
Journal of molecular and cellular cardiology 1992;24(5):451-5.
1992: Denis Escande; M Mestre; I Cavero; J Brugada; C Kirchhof
RP 58866 and its active enantiomer RP 62719 (terikalant): blockers of the inward rectifier K+ current acting as pure class III antiarrhythmic agents.
Journal of cardiovascular pharmacology 1992;20 Suppl 2():S106-13.
1991: Evelyne Benoit; Denis Escande
Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre.
Pflügers Archiv : European journal of physiology 1991;419(6):603-9.
1990: Arthur A M Wilde; Denis Escande; Cees A Schumacher; D Thuringer; M Mestre; Jan W T Fiolet; Michiel J Janse
Potassium accumulation in the globally ischemic mammalian heart. A role for the ATP-sensitive potassium channel.
Circulation research 1990;67(4):835-43.
1989: D Thuringer; Denis Escande
Apparent competition between ATP and the potassium channel opener RP 49356 on ATP-sensitive K+ channels of cardiac myocytes.
Molecular pharmacology 1989;36(6):897-902.
1989: Isabelle Baro; Denis Escande
A long lasting Ca2+-activated outward current in guinea-pig atrial myocytes.
Pflügers Archiv : European journal of physiology 1989;415(1):63-71.
1989: Denis Escande; D Thuringer; S Le Guern; J Courteix; M Laville; I Cavero
Potassium channel openers act through an activation of ATP-sensitive K+ channels in guinea-pig cardiac myocytes.
Pflügers Archiv : European journal of physiology 1989;414(6):669-75.
1989: P Lauribe; Denis Escande; R Nottin; E Coraboeuf
Electrical activity of human atrial fibres at frequencies corresponding to atrial flutter.
Cardiovascular research 1989;23(2):159-68.
1989: D Thuringer; Denis Escande
The potassium channel opener RP 49356 modifies the ATP-sensitivity of K+-ATP channels in cardiac myocytes.
Pflügers Archiv : European journal of physiology 1989;414 Suppl 1():S175.
1989: Isabelle Baro; Denis Escande
A Ca2+-activated K+ current in guinea-pig atrial myocytes.
Pflügers Archiv : European journal of physiology 1989;414 Suppl 1():S168.
1989: Arthur A M Wilde; Denis Escande; Cees A Schumacher; D Thuringer; M Mestre; Jan W T Fiolet
Glibenclamide inhibition of ATP-sensitive K+ channels and ischemia-induced K+ accumulation in the mammalian heart.
Pflügers Archiv : European journal of physiology 1989;414 Suppl 1():S176.
1988: Denis Escande; D Thuringer; S Leguern; I Cavero
The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes.
Biochemical and biophysical research communications 1988;154(2):620-5.
1988: E Coraboeuf; Edith Deroubaix; Denis Escande; Alain Coulombe
Comparative effects of three class I antiarrhythmic drugs on plateau and pacemaker currents of sheep cardiac Purkinje fibres.
Cardiovascular research 1988;22(6):375-84.
1987: Denis Escande; E Coraboeuf; C Planché
Abnormal pacemaking is modulated by sarcoplasmic reticulum in partially-depolarized myocardium from dilated right atria in humans.
Journal of molecular and cellular cardiology 1987;19(3):231-41.
1987: Denis Escande; Alain Coulombe; J F Faivre; Edith Deroubaix; E Coraboeuf
Two types of transient outward currents in adult human atrial cells.
The American journal of physiology 1987;252(1 Pt 2):H142-8.
1986: Denis Escande; Alain Coulombe; J F Faivre; E Coraboeuf
Characteristics of the time-dependent slow inward current in adult human atrial single myocytes.
Journal of molecular and cellular cardiology 1986;18(5):547-51.
1986: Denis Escande; E Coraboeuf; C Planché; F Lacour-Gayet
Effects of potassium conductance inhibitors on spontaneous diastolic depolarization and abnormal automaticity in human atrial fibers.
Basic research in cardiology 1986;81(3):244-57.
1985: Denis Escande; E Coraboeuf
[Cellular electrophysiology of abnormal automaticity foci].
Archives des maladies du coeur et des vaisseaux 1985;78(13):1969-77.
1985: Denis Escande; D Loisance; C Planche; E Coraboeuf
Age-related changes of action potential plateau shape in isolated human atrial fibers.
The American journal of physiology 1985;249(4 Pt 2):H843-50.
1985: Denis Escande; E Coraboeuf; J P Binet
[The variability in the duration of human atrial action potentials increases with age].
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1985;301(10):477-81.