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Francisco Escobar del Rey

Research Profile

Chemicals & Drugs

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Physiology

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Thyroidectomy

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Publications

TOP 3
Pere Berbel; Maria Jesus Obregón; Juan Bernal; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Iodine supplementation during pregnancy: a public health challenge.
Gabriella Morreale de Escobar; Francisco Escobar del Rey
Iodine nutrition--more is better.
Maria Jesus Obregón; Francisco Escobar del Rey; Gabriella Morreale de Escobar
The effects of iodine deficiency on thyroid hormone deiodination.

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All Publications

2007: Pere Berbel; Maria Jesus Obregón; Juan Bernal; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Iodine supplementation during pregnancy: a public health challenge.
Trends in endocrinology and metabolism: TEM 2007;18(9):338-43.
2006: Gabriella Morreale de Escobar; Francisco Escobar del Rey
Iodine nutrition--more is better.
The New England journal of medicine 2006;355(14):1500-1; author reply 1501.
2005: Maria Jesus Obregón; Francisco Escobar del Rey; Gabriella Morreale de Escobar
The effects of iodine deficiency on thyroid hormone deiodination.
Thyroid : official journal of the American Thyroid Association 2005;15(8):917-29.
2005: Héctor F Escobar-Morreale; José I Botella Carretero; Francisco Escobar del Rey; Gabriella Morreale de Escobar
REVIEW: Treatment of hypothyroidism with combinations of levothyroxine plus liothyronine.
The Journal of clinical endocrinology and metabolism 2005;90(8):4946-54.
2004: Gabriella Morreale de Escobar; Maria Jesus Obregón; Francisco Escobar del Rey
Role of thyroid hormone during early brain development.
European journal of endocrinology / European Federation of Endocrine Societies 2004;151 Suppl 3():U25-37.
2004: Juan Ramon Martinez-Galan; Francisco Escobar del Rey; Gabriella Morreale de Escobar; Maria Santacana; Antonio Ruiz-Marcos
Hypothyroidism alters the development of radial glial cells in the term fetal and postnatal neocortex of the rat.
Brain research. Developmental brain research 2004;153(1):109-14.
2003: Rosalía Lavado-Autric; Eva Ausó; José Victor García-Velasco; María del Carmen Arufe; Francisco Escobar del Rey; Pere Berbel; Gabriella Morreale de Escobar
Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny.
The Journal of clinical investigation 2003;111(7):1073-82.
2000: Gabriella Morreale de Escobar; Maria Jesus Obregón; Francisco Escobar del Rey
Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia?
The Journal of clinical endocrinology and metabolism 2000;85(11):3975-87.
2000: Gabriella Morreale de Escobar; Francisco Escobar del Rey
[Iodine during pregnancy, lactation and infancy. Minimum and maximum doses: from micrograms to grams].
Anales españoles de pediatría 2000;53(1):1-5.
1999: Gabriella Morreale de Escobar; Francisco Escobar del Rey
Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child.
The New England journal of medicine 1999;341(26):2015-6; author reply 2017.
1999: Héctor F Escobar-Morreale; Maria Jesus Obregón; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Tissue-specific patterns of changes in 3,5,3'-triiodo-L-thyronine concentrations in thyroidectomized rats infused with increasing doses of the hormone. Which are the regulatory mechanisms?
Biochimie 1999;81(5):453-62.
1998: Rosa M Calvo; R Forcen; Maria Jesus Obregón; Francisco Escobar del Rey; Gabriella Morreale de Escobar; J Regadera
Immunohistochemical and morphometric studies of the fetal pancreas in diabetic pregnant rats. Effects of insulin administration.
The Anatomical record 1998;251(2):173-80.
1998: Gabriella Morreale de Escobar; Francisco Escobar del Rey
[Iodine deficiency and children's rights].
Anales de la Real Academia Nacional de Medicina 1998;115(3):683-701; discussion 701-2.
1997: Héctor F Escobar-Morreale; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Thyroid hormones influence serum leptin concentrations in the rat.
Endocrinology 1997;138(10):4485-8.
1997: Juan Ramon Martinez-Galan; Pablo Enrique Pedraza; Maria Santacana; Francisco Escobar del Rey; Gabriella Morreale de Escobar; Antonio Ruiz-Marcos
Myelin basic protein immunoreactivity in the internal capsule of neonates from rats on a low iodine intake or on methylmercaptoimidazole (MMI).
Brain research. Developmental brain research 1997;101(1-2):249-56.
1997: Héctor F Escobar-Morreale; Maria Jesus Obregón; A Hernandez; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Regulation of iodothyronine deiodinase activity as studied in thyroidectomized rats infused with thyroxine or triiodothyronine.
Endocrinology 1997;138(6):2559-68.
1997: R Calvo; Gabriella Morreale de Escobar; Francisco Escobar del Rey; Maria Jesus Obregón
Maternal nonthyroidal illness and fetal thyroid hormone status, as studied in the streptozotocin-induced diabetes mellitus rat model.
Endocrinology 1997;138(3):1159-69.
1997: R Calvo; Gabriella Morreale de Escobar; Francisco Escobar del Rey; Maria Jesus Obregón
Maternal diabetes mellitus, a rat model for nonthyroidal illness: correction of hypothyroxinemia with thyroxine treatment does not improve fetal thyroid hormone status.
Thyroid : official journal of the American Thyroid Association 1997;7(1):79-87.
1996: Pablo Enrique Pedraza; R Calvo; Maria Jesus Obregón; M Asunción; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Displacement of T4 from transthyretin by the synthetic flavonoid EMD 21388 results in increased production of T3 from T4 in rat dams and fetuses.
Endocrinology 1996;137(11):4902-14.
1996: Maria Jesus Obregón; R Calvo; A Hernández; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Regulation of uncoupling protein messenger ribonucleic acid and 5'-deiodinase activity by thyroid hormones in fetal brown adipose tissue.
Endocrinology 1996;137(11):4721-9.
1995: Héctor F Escobar-Morreale; Maria Jesus Obregón; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats.
The Journal of clinical investigation 1995;96(6):2828-38.
1995: F Chapa; B Künnecke; R Calvo; Francisco Escobar del Rey; Gabriella Morreale de Escobar; Sebastián Cerdán
Adult-onset hypothyroidism and the cerebral metabolism of (1,2-13C2) acetate as detected by 13C nuclear magnetic resonance.
Endocrinology 1995;136(1):296-305.
1994: Antonio Ruiz-Marcos; P Cartagena-Abella; J R Martinez-Galan; R Calvo; Gabriella Morreale de Escobar; Francisco Escobar del Rey
Thyroxine treatment and the recovery of pyramidal cells of the cerebral cortex from changes induced by juvenile-onset hypothyroidism.
Journal of neurobiology 1994;25(7):808-18.
1994: Gabriella Morreale de Escobar; R Calvo; Francisco Escobar del Rey; Maria Jesus Obregón
Thyroid hormones in tissues from fetal and adult rats.
Endocrinology 1994;134(6):2410-5.
1993: Gabriella Morreale de Escobar; R Calvo; Francisco Escobar del Rey; Maria Jesus Obregón
Differential effects of thyroid hormones on growth and thyrotropic hormones in rat fetuses near term.
Endocrinology 1993;132(5):2056-64.
1993: Gabriella Morreale de Escobar; Maria Jesus Obregón; R Calvo; Francisco Escobar del Rey
Effects of iodine deficiency on thyroid hormone metabolism and the brain in fetal rats: the role of the maternal transfer of thyroxin.
The American journal of clinical nutrition 1993;57(2 Suppl):280S-285S.
1992: R Calvo; Maria Jesus Obregón; Francisco Escobar del Rey; Gabriella Morreale de Escobar
The rat placenta and the transfer of thyroid hormones from the mother to the fetus. Effects of maternal thyroid status.
Endocrinology 1992;131(1):357-65.
1992: Gabriella Morreale de Escobar; R Calvo; Maria Jesus Obregón; Francisco Escobar del Rey
Homeostasis of brain T3 in rat fetuses and their mothers: effects of thyroid status and iodine deficiency.
Acta medica Austriaca 1992;19 Suppl 1():110-6.
1991: Maria Jesus Obregón; C Ruiz de Oña; R Calvo; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Outer ring iodothyronine deiodinases and thyroid hormone economy: responses to iodine deficiency in the rat fetus and neonate.
Endocrinology 1991;129(5):2663-73.
1991: C Ruiz de Oña; Gabriella Morreale de Escobar; R Calvo; Francisco Escobar del Rey; Maria Jesus Obregón
Thyroid hormones and 5'-deiodinase in the rat fetus late in gestation: effects of maternal hypothyroidism.
Endocrinology 1991;128(1):422-32.
1991: Gabriella Morreale de Escobar; Maria Jesus Obregón; R Calvo; Francisco Escobar del Rey
Maternal thyroid hormones during pregnancy: effects on the fetus in congenital hypothyroidism and in iodine deficiency.
Advances in experimental medicine and biology 1991;299():133-56.
1991: R Gil-Garay; C Miralles-Flores; Maria Jesus Obregón; Francisco Escobar del Rey; Gabriella Morreale de Escobar; Emilio Delgado-Baeza
Maternal hypothyroidism and fetal chondro-osseous development in rats.
Biology of the neonate 1991;60(6):385-94.
1990: R Calvo; Maria Jesus Obregón; C Ruiz de Oña; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Congenital hypothyroidism, as studied in rats. Crucial role of maternal thyroxine but not of 3,5,3'-triiodothyronine in the protection of the fetal brain.
The Journal of clinical investigation 1990;86(3):889-99.
1990: Gabriella Morreale de Escobar; R Calvo; Maria Jesus Obregón; Francisco Escobar del Rey
Contribution of maternal thyroxine to fetal thyroxine pools in normal rats near term.
Endocrinology 1990;126(5):2765-7.
1989: Maria Jesus Obregón; C Ruiz de Oña; A Hernandez; R Calvo; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Thyroid hormones and 5'-deiodinase in rat brown adipose tissue during fetal life.
The American journal of physiology 1989;257(5 Pt 1):E625-31.
1989: Francisco Escobar del Rey; C Ruiz de Oña; J Bernal; Maria Jesus Obregón; Gabriella Morreale de Escobar
Generalized deficiency of 3,5,3'-triiodo-L-thyronine (T3) in tissues from rats on a low iodine intake, despite normal circulating T3 levels.
Acta endocrinologica 1989;120(4):490-8.
1989: Gabriella Morreale de Escobar; Maria Jesus Obregón; C Ruiz de Oña; Francisco Escobar del Rey
Comparison of maternal to fetal transfer of 3,5,3'-triiodothyronine versus thyroxine in rats, as assessed from 3,5,3'-triiodothyronine levels in fetal tissues.
Acta endocrinologica 1989;120(1):20-30.
1988: C Ruiz de Oña; Maria Jesus Obregón; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Developmental changes in rat brain 5'-deiodinase and thyroid hormones during the fetal period: the effects of fetal hypothyroidism and maternal thyroid hormones.
Pediatric research 1988;24(5):588-94.
1988: Gabriella Morreale de Escobar; Maria Jesus Obregón; C Ruiz de Oña; Francisco Escobar del Rey
Transfer of thyroxine from the mother to the rat fetus near term: effects on brain 3,5,3'-triiodothyronine deficiency.
Endocrinology 1988;122(4):1521-31.
1988: Antonio Ruiz-Marcos; P Cartagena Abella; A García García; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Rapid effects of adult-onset hypothyroidism on dendritic spines of pyramidal cells of the rat cerebral cortex.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1988;73(3):583-8.
1988: Gabriella Morreale de Escobar; Maria Jesus Obregón; Francisco Escobar del Rey
Maternal-fetal thyroid hormone relationships and the fetal brain.
Acta medica Austriaca 1988;15 Suppl 1():66-70.
1987: S L Ipiña; Antonio Ruiz-Marcos; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Pyramidal cortical cell morphology studied by multivariate analysis: effects of neonatal thyroidectomy, ageing and thyroxine-substitution therapy.
Brain research 1987;465(1-2):219-29.
1987: Francisco Escobar del Rey; JESUS MALLOL; R Pastor; Gabriella Morreale de Escobar
Effects of maternal iodine deficiency on thyroid hormone economy of lactating dams and pups: maintenance of normal cerebral 3,5,3'-triiodo-L-thyronine concentrations in pups during major phases of brain development.
Endocrinology 1987;121(2):803-11.
1987: Gabriella Morreale de Escobar; Maria Jesus Obregón; Francisco Escobar del Rey
Fetal and maternal thyroid hormones.
Hormone research 1987;26(1-4):12-27.
1986: Francisco Escobar del Rey; R Pastor; JESUS MALLOL; Gabriella Morreale de Escobar
Effects of maternal iodine deficiency on the L-thyroxine and 3,5,3'-triiodo-L-thyronine contents of rat embryonic tissues before and after onset of fetal thyroid function.
Endocrinology 1986;118(4):1259-65.
1985: Gabriella Morreale de Escobar; R Pastor; Maria Jesus Obregón; Francisco Escobar del Rey
Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function.
Endocrinology 1985;117(5):1890-900.
1985: P J Berbel; Francisco Escobar del Rey; Gabriella Morreale de Escobar; Antonio Ruiz-Marcos
Effect of hypothyroidism on the size of spines of pyramidal neurons of the cerebral cortex.
Brain research 1985;337(2):217-23.
1984: Maria Jesus Obregón; Pilar Santisteban; A Rodríguez-Peña; A Pascual; P Cartagena; Antonio Ruiz-Marcos; L Lamas; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Cerebral hypothyroidism in rats with adult-onset iodine deficiency.
Endocrinology 1984;115(2):614-24.
1984: Maria Jesus Obregón; JESUS MALLOL; R Pastor; Gabriella Morreale de Escobar; Francisco Escobar del Rey
L-thyroxine and 3,5,3'-triiodo-L-thyronine in rat embryos before onset of fetal thyroid function.
Endocrinology 1984;114(1):305-7.
1983: Antonio Ruiz-Marcos; J Salas; F Sanchez-Toscano; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Effect of neonatal and adult-onset hypothyroidism on pyramidal cells of the rat auditory cortex.
Brain research 1983;285(2):205-13.
1982: Antonio Ruiz-Marcos; F Sanchez-Toscano; Maria Jesus Obregón; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Thyroxine treatment and recovery of hypothyroidism-induced pyramidal cell damage.
Brain research 1982;239(2):559-74.
1981: Maria Jesus Obregón; JESUS MALLOL; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Presence of L-thyroxine and 3,5,3'-triiodo-L-thyronine in tissues from thyroidectomized rats.
Endocrinology 1981;109(3):908-13.
1981: SANTIAGO DURAN; Maria Jesus Obregón; Gabriella Morreale de Escobar; Francisco Escobar del Rey
Differential effects of hypothyroidism on the specific uptake of growth hormone and prolactin by the rat liver.
Endocrinology 1981;108(6):2054-9.
1981: Francisco Escobar del Rey; A Gomez-Pan; Maria Jesus Obregón; JESUS MALLOL; M D Arnao; A Aranda; Gabriella Morreale de Escobar
A survey of schoolchildren from a severe endemic goitre area in Spain.
The Quarterly journal of medicine 1981;50(198):233-46.
1980: Maria Jesus Obregón; A Pascual; JESUS MALLOL; Gabriella Morreale de Escobar; Francisco Escobar del Rey
Evidence against a major role of L-thyroxine at the pituitary level: studies in rats treated with iopanoic acid (telepaque).
Endocrinology 1980;106(6):1827-36.
1980: Antonio Ruiz-Marcos; F Sánchez-Toscano; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Reversible morphological alterations of cortical neurons in juvenile and adult hypothyroidism in the rat.
Brain research 1980;185(1):91-102.