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Jeffrey Esko

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Leslie Cantley; Di Chen; John P Dormans; Shuji Asai; Maria Elena Candela; Jeffrey D Esko; Marta Guttenberg; Jacqueline T Hecht; Masahiro Iwamoto; Naoki Kondo; Yoichi Ohta; Maurizio Pacifici; Ling Qin; Cheri Saunders; Federica Sgariglia; Satoru Toyosawa; Yu Yamaguchi; Masato Yamamoto; Rika Yasuhara; Xianrong Zhang; Motomi Enomoto-Iwamoto
Loss of β-catenin induces multifocal periosteal chondroma-like masses in mice.
Kevin T Bush; Brett E Crawford; Jeffrey D Esko; Omai B Garner; Kabir B Nigam; Sanjay K Nigam
N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland.
William C Lamanna; Carlos Lameda-Diaz; Roger Lawrence; Kelley W Moremen; Stéphane Sarrazin; Philip L S M Gordts; Jeffrey D Esko
A genetic model of substrate reduction therapy for mucopolysaccharidosis.

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All Publications

2013: Leslie Cantley; Di Chen; John P Dormans; Shuji Asai; Maria Elena Candela; Jeffrey D Esko; Marta Guttenberg; Jacqueline T Hecht; Masahiro Iwamoto; Naoki Kondo; Yoichi Ohta; Maurizio Pacifici; Ling Qin; Cheri Saunders; Federica Sgariglia; Satoru Toyosawa; Yu Yamaguchi; Masato Yamamoto; Rika Yasuhara; Xianrong Zhang; Motomi Enomoto-Iwamoto
Loss of β-catenin induces multifocal periosteal chondroma-like masses in mice.
The American journal of pathology 2013;182(3):917-27.
2012: Kevin T Bush; Brett E Crawford; Jeffrey D Esko; Omai B Garner; Kabir B Nigam; Sanjay K Nigam
N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland.
The Journal of biological chemistry 2012;287(50):42064-70.
2012: William C Lamanna; Carlos Lameda-Diaz; Roger Lawrence; Kelley W Moremen; Stéphane Sarrazin; Philip L S M Gordts; Jeffrey D Esko
A genetic model of substrate reduction therapy for mucopolysaccharidosis.
The Journal of biological chemistry 2012;287(43):36283-90.
2012: Jakob Axelsson; Tracy M Handel; Klaus Ley; Julia K Nussbacher; Pragada Sriramarao; Ding Xu; Bit Na Kang; Jeffrey D Esko
Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice.
Blood 2012;120(8):1742-51.
2012: Anne K Bergfeld; Biswa Choudhury; Sandra L Diaz; Jeffrey D Esko; Roger Lawrence; Oliver M T Pearce; David J Vocadlo; Ajit Varki
Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine.
The Journal of biological chemistry 2012;287(34):28898-916.
2012: Björn Kowalewski; William C Lamanna; Roger Lawrence; Torben Lübke; Renate Lüllmann-Rauch; Michael Padva; Stijn Stroobants; Markus Damme; Rudi D'Hooge; Jeffrey D Esko; Marc-André Frese; Ina Kalus; Thomas Dierks
Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(26):10310-5.
2012: Sébastien Le Jan; Ola Söderberg; Dorothe Spillmann; Irene Weibrecht; Joseph R Bishop; Lena Claesson-Welsh; Inger Eriksson; Jeffrey D Esko; Makoto Hayashi; Johan Heldin; Katarina Holmborn; Lars Jakobsson; Zsolt Kasza; Lena Kjellén; Johan Kreuger
Functional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(5):1255-63.
2012: Jong Youn Baik; Payel Datta; Jeffrey D Esko; Leyla Gasimli; Charles A Glass; Robert J Linhardt; Bo Yang; Fuming Zhang; Susan T Sharfstein
Metabolic engineering of Chinese hamster ovary cells: towards a bioengineered heparin.
Metabolic engineering 2012;14(2):81-90.
2012: Roger Lawrence; Jeffrey D Esko; William C Lamanna; Kanar Al-Mafraji; James R Beitel; Gerardus Josephus Boons; Jillian R Brown; Brett E Crawford
Disease-specific non-reducing end carbohydrate biomarkers for mucopolysaccharidoses.
Nature chemical biology 2012;8(2):197-204.
2011: Ding Xu; Jeffrey Young; Danyin Song; Jeffrey D Esko
Heparan sulfate is essential for high mobility group protein 1 (HMGB1) signaling by the receptor for advanced glycation end products (RAGE).
The Journal of biological chemistry 2011;286(48):41736-44.
2011: M Anna Kowalska; Senthil Kumar Krishnaswamy; Lubica Rauova; Li Zhai; Karine Amirikian; Richard H Aster; Daniel W Bougie; Douglas B Cines; Jeffrey D Esko; Vincent Hayes; Mortimer Poncz
Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT.
Blood 2011;118(10):2882-8.
2011: Mita M Shah; Derina E Sweeney; Hiroyuki Sakurai; Kevin T Bush; Jeffrey D Esko; Thomas F Gallegos; Sanjay K Nigam
Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate.
Developmental biology 2011;356(1):19-27.
2011: Omai B Garner; Kabir B Nigam; Kevin T Bush; Jeffrey D Esko; Ding Xu; Yu Yamaguchi; Sanjay K Nigam
Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.
Developmental biology 2011;355(2):394-403.
2011: Stephane Sarrazin; William C Lamanna; Jeffrey D Esko
Heparan sulfate proteoglycans.
Cold Spring Harbor perspectives in biology 2011;3(7):.
2011: Yung-Chi Chang; Jeffrey D Esko; Lindsay A Flax; Victor Nizet; Zhipeng Wang; Ding Xu; Miriam J Baron
Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems.
PLoS pathogens 2011;7(6):e1002082.
2011: Beverly M Zak; Manuela Schuksz; Eiki Koyama; Christina Mundy; Dan E Wells; Yu Yamaguchi; Maurizio Pacifici; Jeffrey D Esko
Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones.
Bone 2011;48(5):979-87.
2011: Xiuxia Qu; Christian Carbe; Chenqi Tao; Andrea Powers; Roger Lawrence; Toin H van Kuppevelt; Wellington V Cardoso; Kay Grobe; Jeffrey D Esko; Xin Zhang
Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate.
The Journal of biological chemistry 2011;286(16):14435-44.
2011: William C Lamanna; Roger Lawrence; Stéphane Sarrazin; Jeffrey D Esko
Secondary storage of dermatan sulfate in Sanfilippo disease.
The Journal of biological chemistry 2011;286(9):6955-62.
2011: Tarsis F Gesteira; Vivien J Coulson-Thomas; Alessandro Taunay-Rodrigues; Vitor Oliveira; Bryan E Thacker; Maria A Juliano; Renata Pasqualini; Wadih Arap; Ivarne L S Tersariol; Helena B Nader; Jeffrey D Esko; Maria A S Pinhal
Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1.
The Journal of biological chemistry 2011;286(7):5338-46.
2011: Ding Xu; Mark M Fuster; Roger Lawrence; Jeffrey D Esko
Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability.
The Journal of biological chemistry 2011;286(1):737-45.
2010: Andrew V Dix; Lucile Fischer; Stéphane Sarrazin; Christopher P H Redgate; Jeffrey D Esko; Yitzhak Tor
Cooperative, heparan sulfate-dependent cellular uptake of dimeric guanidinoglycosides.
Chembiochem : a European journal of chemical biology 2010;11(16):2302-10.
2010: Neeta Adhikari; David L Basi; DeWayne Townsend; Melissa Rusch; Ami Mariash; Sureni Mullegama; Adrienne Watson; Jon Larson; Sara Tan; Ben Lerman; Jeffrey D Esko; Scott B Selleck; Jennifer L Hall
Heparan sulfate Ndst1 regulates vascular smooth muscle cell proliferation, vessel size and vascular remodeling.
Journal of molecular and cellular cardiology 2010;49(2):287-93.
2010: Stéphane Sarrazin; Beth Wilson; William S Sly; Yitzhak Tor; Jeffrey D Esko
Guanidinylated neomycin mediates heparan sulfate-dependent transport of active enzymes to lysosomes.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(7):1268-74.
2010: Joseph R Bishop; Erin Foley; Roger Lawrence; Jeffrey D Esko
Insulin-dependent diabetes mellitus in mice does not alter liver heparan sulfate.
The Journal of biological chemistry 2010;285(19):14658-62.
2010: Mita M Shah; Hiroyuki Sakurai; Derina E Sweeney; Thomas F Gallegos; Kevin T Bush; Jeffrey D Esko; Sanjay K Nigam
Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching.
Developmental biology 2010;339(2):354-65.
2010: Joseph Bishop; Maria Rita Passos-Bueno; Loren Fong; Kristin I Stanford; Jon C Gonzales; Erika Yeh; Stephen G Young; Andre Bensadoun; Joseph L Witztum; Jeffrey D Esko; Karen S Moulton
Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans.
PloS one 2010;5(11):e13919.
2010: Erin M Foley; Jeffrey D Esko
Hepatic heparan sulfate proteoglycans and endocytic clearance of triglyceride-rich lipoproteins.
Progress in molecular biology and translational science 2010;93():213-33.
2010: Brett E Crawford; Omai B Garner; Joseph Bishop; David Y Zhang; Kevin T Bush; Sanjay K Nigam; Jeffrey D Esko
Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice.
PloS one 2010;5(5):e10691.
2010: Erbin Dai; Li-Ying Liu; Hao Wang; Dana McIvor; Yun Ming Sun; Colin Macaulay; Elaine King; Ganesh Munuswamy-Ramanujam; Mee Yong Bartee; Jennifer Williams; Jennifer Davids; Israel Charo; Grant McFadden; Jeffrey D Esko; Alexandra R Lucas
Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejection.
PloS one 2010;5(5):e10510.
2010: Kristin I Stanford; Lianchun Wang; Jan Castagnola; Danyin Song; Joseph Bishop; Jillian R Brown; Roger Lawrence; Xaiomei Bai; Hiroko Habuchi; Masakazu Tanaka; Wellington V Cardoso; Koji Kimata; Jeffrey D Esko
Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance.
The Journal of biological chemistry 2010;285(1):286-94.
2009: Ajit Varki; Richard D Cummings; Jeffrey D Esko; Hudson H Freeze; Pamela Stanley; Jamey D Marth; Carolyn R Bertozzi; Gerald W Hart; Marilynn E Etzler
Symbol nomenclature for glycan representation.
Proteomics 2009;9(24):5398-9.
2009: Bing Zhang; Ursula M Dietrich; Jian-Guo Geng; Roy Bicknell; Jeffrey D Esko; Lianchun Wang
Repulsive axon guidance molecule Slit3 is a novel angiogenic factor.
Blood 2009;114(19):4300-9.
2009: Kristin I Stanford; Joseph Bishop; Erin M Foley; Jon C Gonzales; Ingrid R Niesman; Joseph L Witztum; Jeffrey D Esko
Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice.
The Journal of clinical investigation 2009;119(11):3236-45.
2009: Riaz I Zuberi; Xiao Na Ge; Shuxia Jiang; Nooshin S Bahaie; Bit-Na Kang; Reza M Hosseinkhani; Elizabeth M Frenzel; Mark M Fuster; Jeffrey D Esko; Savita P Rao; P Sriramarao
Deficiency of endothelial heparan sulfates attenuates allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3971-9.
2009: Ding Xu; Jeffrey D Esko
A Golgi-on-a-chip for glycan synthesis.
Nature chemical biology 2009;5(9):612-3.
2009: Sayumi Yamazoe; Hiroki Shimogawa; Shin-ichi Sato; Jeffrey D Esko; Motonari Uesugi
A dumbbell-shaped small molecule that promotes cell adhesion and growth.
Chemistry & biology 2009;16(7):773-82.
2009: John K Meissen; Matthew D Sweeney; Matthew Girardi; Roger Lawrence; Jeffrey D Esko; Julie A Leary
Differentiation of 3-O-sulfated heparin disaccharide isomers: identification of structural aspects of the heparin CCL2 binding motif.
Journal of the American Society for Mass Spectrometry 2009;20(4):652-7.
2009: Jillian R Brown; Feng Yang; Anjana Sinha; Boopathy Ramakrishnan; Yitzhak Tor; Pradman K Qasba; Jeffrey D Esko
Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis.
The Journal of biological chemistry 2009;284(8):4952-9.
2009: Hans Bakker; Takuji Oka; Angel Ashikov; Ajit Yadav; Monika Berger; Nadia A Rana; Xiaomei Bai; Yoshifumi Jigami; Robert S Haltiwanger; Jeffrey D Esko; Rita Gerardy-Schahn
Functional UDP-xylose transport across the endoplasmic reticulum/Golgi membrane in a Chinese hamster ovary cell mutant defective in UDP-xylose Synthase.
The Journal of biological chemistry 2009;284(4):2576-83.
2008: Michael M Weinstein; Liya Yin; Anne P Beigneux; Brandon S J Davies; Peter Gin; Kristine Estrada; Kristan Melford; Joseph R Bishop; Jeffrey D Esko; Geesje M Dallinga-Thie; Loren G Fong; André Bensadoun; Stephen G Young
Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice.
The Journal of biological chemistry 2008;283(50):34511-8.
2008: Roger Lawrence; Sara K Olson; Robert E Steele; Lianchun Wang; Rahul Warrior; Richard D Cummings; Jeffrey D Esko
Evolutionary differences in glycosaminoglycan fine structure detected by quantitative glycan reductive isotope labeling.
The Journal of biological chemistry 2008;283(48):33674-84.
2008: Omai B Garner; Yu Yamaguchi; Jeffrey D Esko; Vibeke Videm
Small changes in lymphocyte development and activation in mice through tissue-specific alteration of heparan sulphate.
Immunology 2008;125(3):420-9.
2008: Ajit Varki; Linda G Baum; Susan L Bellis; Richard D Cummings; Jeffrey D Esko; Gerald W Hart; Robert J Linhardt; John B Lowe; Rodger P McEver; Arun Srivastava; Rita Sarkar
Working group report: the roles of glycans in hemostasis, inflammation and vascular biology.
Glycobiology 2008;18(10):747-9.
2008: Manuela Schuksz; Mark M Fuster; Jillian R Brown; Brett E Crawford; David P Ditto; Roger Lawrence; Charles A Glass; Lianchun Wang; Yitzhak Tor; Jeffrey D Esko
Surfen, a small molecule antagonist of heparan sulfate.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):13075-80.
2008: Srinivas Reddy Pallerla; Roger Lawrence; Lars Lewejohann; Yi Pan; Tobias Fischer; Uwe Schlomann; Xin Zhang; Jeffrey D Esko; Kay Grobe
Altered heparan sulfate structure in mice with deleted NDST3 gene function.
The Journal of biological chemistry 2008;283(24):16885-94.
2008: Joseph Bishop; Kristin I Stanford; Jeffrey D Esko
Heparan sulfate proteoglycans and triglyceride-rich lipoprotein metabolism.
Current opinion in lipidology 2008;19(3):307-13.
2008: Roger Lawrence; Hong Lu; Robert D Rosenberg; Jeffrey D Esko; Lijuan Zhang
Disaccharide structure code for the easy representation of constituent oligosaccharides from glycosaminoglycans.
Nature methods 2008;5(4):291-2.
2008: Yi Pan; Christian Carbe; Andrea Powers; Eric Erquan Zhang; Jeffrey D Esko; Kay Grobe; Gen-Sheng Feng; Xin Zhang
Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction.
Development (Cambridge, England) 2008;135(2):301-10.
2008: Lars Bode; Camilla Salvestrini; Pyong Woo Park; Jin-Ping Li; Jeffrey D Esko; Yu Yamaguchi; Simon H Murch; Hudson H Freeze
Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function.
The Journal of clinical investigation 2008;118(1):229-38.
2007: Alida Coppi; Rita Tewari; Joseph Bishop; Brandy L Bennett; Roger Lawrence; Jeffrey D Esko; Oliver Billker; Photini Sinnis
Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells.
Cell host & microbe 2007;2(5):316-27.
2007: Jillian R Brown; Brett E Crawford; Jeffrey D Esko
Glycan antagonists and inhibitors: a fount for drug discovery.
Critical reviews in biochemistry and molecular biology 2007;42(6):481-515.
2007: Claire E Johnson; Brett E Crawford; Marios Stavridis; Gerdy B ten Dam; Annie L Wat; Graham Rushton; Christopher M Ward; Valerie Wilson; Toin H van Kuppevelt; Jeffrey D Esko; Austin Smith; John T Gallagher; Catherine L R Merry
Essential alterations of heparan sulfate during the differentiation of embryonic stem cells to Sox1-enhanced green fluorescent protein-expressing neural progenitor cells.
Stem cells (Dayton, Ohio) 2007;25(8):1913-23.
2007: Lubor Borsig; Lianchun Wang; Moisés C M Cavalcante; Larissa Cardilo-Reis; Paola L Ferreira; Paulo A S Mourão; Jeffrey D Esko; Mauro Pavão
Selectin blocking activity of a fucosylated chondroitin sulfate glycosaminoglycan from sea cucumber. Effect on tumor metastasis and neutrophil recruitment.
The Journal of biological chemistry 2007;282(20):14984-91.
2007: Mark M Fuster; Lianchun Wang; Janice Castagnola; Lyudmila Sikora; Krisanavane Reddi; Phillip H A Lee; Katherine A Radek; Manuela Schuksz; Joseph Bishop; Richard L Gallo; Pragada Sriramarao; Jeffrey D Esko
Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis.
The Journal of cell biology 2007;177(3):539-49.
2007: Lev Elson-Schwab; Omai Garner; Manuela Schuksz; Brett E Crawford; Jeffrey D Esko; Yitzhak Tor
Guanidinylated neomycin delivers large, bioactive cargo into cells through a heparan sulfate-dependent pathway.
The Journal of biological chemistry 2007;282(18):13585-91.
2007: Joseph Bishop; Manuela Schuksz; Jeffrey D Esko
Heparan sulphate proteoglycans fine-tune mammalian physiology.
Nature 2007;446(7139):1030-7.
2007: Claudia Pönighaus; Michael Ambrosius; Javier Carrera Casanova; Christian Prante; Joachim Kuhn; Jeffrey D Esko; Knut Kleesiek; Christian Götting
Human xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans.
The Journal of biological chemistry 2007;282(8):5201-6.
2007: Aaron M Bender; Natalia V Kirienko; Sara K Olson; Jeffrey D Esko; David Fay
lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans.
Developmental biology 2007;302(2):448-62.
2007: Srinivas Reddy Pallerla; Yi Pan; Xin Zhang; Jeffrey D Esko; Kay Grobe
Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(2):556-63.
2007: Jennifer M MacArthur; Joseph Bishop; Kristin I Stanford; Lianchun Wang; André Bensadoun; Joseph L Witztum; Jeffrey D Esko
Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members.
The Journal of clinical investigation 2007;117(1):153-64.
2006: Yi Pan; Andrea Woodbury; Jeffrey D Esko; Kay Grobe; Xin Zhang
Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.
Development (Cambridge, England) 2006;133(24):4933-44.
2006: Sara K Olson; Joseph Bishop; John R Yates; Karen Oegema; Jeffrey D Esko
Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2.
The Journal of cell biology 2006;173(6):985-94.
2006: Andrew R Clamp; Fiona H Blackhall; Audrey Henrioud; Gordon C Jayson; Kashi Javaherian; Jeffrey D Esko; John T Gallagher; Catherine L R Merry
The morphogenic properties of oligomeric endostatin are dependent on cell surface heparan sulfate.
The Journal of biological chemistry 2006;281(21):14813-22.
2006: Jillian R Brown; Mark M Fuster; Ruixia Li; Nissi M Varki; Charles A Glass; Jeffrey D Esko
A disaccharide-based inhibitor of glycosylation attenuates metastatic tumor cell dissemination.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(9):2894-901.
2006: Jillian R Brown; Yoshio Nishimura; Jeffrey D Esko
Synthesis and biological evaluation of gem-diamine 1-N-iminosugars related to L-iduronic acid as inhibitors of heparan sulfate 2-O-sulfotransferase.
Bioorganic & medicinal chemistry letters 2006;16(3):532-6.
2006: Elena M Comelli; Steven R Head; Tim Gilmartin; Thomas Whisenant; Stuart M Haslam; Simon J North; Nyet Kui Wong; Takashi Kudo; Hisashi Narimatsu; Jeffrey D Esko; Kurt Drickamer; Anne Dell; James C Paulson
A focused microarray approach to functional glycomics: transcriptional regulation of the glycome.
Glycobiology 2006;16(2):117-31.
2006: Lijuan Zhang; Roger Lawrence; Beth A Frazier; Jeffrey D Esko
CHO glycosylation mutants: proteoglycans.
Methods in enzymology 2006;416():205-21.
2005: Dominique Stickens; Beverly M Zak; Nathalie Rougier; Jeffrey D Esko; Zena Werb
Mice deficient in Ext2 lack heparan sulfate and develop exostoses.
Development (Cambridge, England) 2005;132(22):5055-68.
2005: Joseph Bishop; Brett E Crawford; Jeffrey D Esko
Cell surface heparan sulfate promotes replication of Toxoplasma gondii.
Infection and immunity 2005;73(9):5395-401.
2005: Lianchun Wang; Mark M Fuster; Pragada Sriramarao; Jeffrey D Esko
Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses.
Nature immunology 2005;6(9):902-10.
2005: Kay Grobe; Masaru Inatani; Srinivas Reddy Pallerla; Jan Castagnola; Yu Yamaguchi; Jeffrey D Esko
Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function.
Development (Cambridge, England) 2005;132(16):3777-86.
2005: SHYAM RELE; WANXING CUI; Lianchun Wang; Sijian Hou; Ginger Barr-Zarse; Daniel Tatton; Yves Gnanou; Jeffrey D Esko; Elliot L Chaikof
Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties.
Journal of the American Chemical Society 2005;127(29):10132-3.
2005: Mark M Fuster; Jeffrey D Esko
The sweet and sour of cancer: glycans as novel therapeutic targets.
Nature reviews. Cancer 2005;5(7):526-42.
2005: Tarja Kinnunen; Zebo Huang; Joanne Townsend; Michelle M Gatdula; Jillian R Brown; Jeffrey D Esko; Jeremy E Turnbull
Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1507-12.
2005: Joseph Bishop; Jeffrey D Esko
The elusive role of heparan sulfate in Toxoplasma gondii infection.
Molecular and biochemical parasitology 2005;139(2):267-9.
2004: Dylan L Steer; Mita M Shah; Kevin T Bush; Robert O Stuart; Rosemary V Sampogna; Tobias N Meyer; Catherine Schwesinger; Xaiomei Bai; Jeffrey D Esko; Sanjay K Nigam
Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney.
Developmental biology 2004;272(2):310-27.
2004: Naoko Nagai; Hiroko Habuchi; Jeffrey D Esko; Koji Kimata
Stem domains of heparan sulfate 6-O-sulfotransferase are required for Golgi localization, oligomer formation and enzyme activity.
Journal of cell science 2004;117(Pt 15):3331-41.
2004: Michael D Bobardt; Patrick Salmon; Lianchun Wang; Jeffrey D Esko; Dana Gabuzda; Milan Fiala; Didier Trono; Bernadette Van der Schueren; Guido David; Philippe A Gallay
Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion.
Journal of virology 2004;78(12):6567-84.
2004: Ge Wei; Xiaomei Bai; Jeffrey D Esko
Temperature-sensitive glycosaminoglycan biosynthesis in a Chinese hamster ovary cell mutant containing a point mutation in glucuronyltransferase I.
The Journal of biological chemistry 2004;279(7):5693-8.
2003: Joel S Griffitts; Danielle L Huffman; Johanna L Whitacre; Brad Barrows; Lisa D Marroquin; Reto Müller; Jillian R Brown; Thierry Hennet; Jeffrey D Esko; Raffi V Aroian
Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions.
The Journal of biological chemistry 2003;278(46):45594-602.
2003: Olga Ben-Zaken; Salit Tzaban; Yuval Tal; Lior Horonchik; Jeffrey D Esko; Israel Vlodavsky; Albert Taraboulos
Cellular heparan sulfate participates in the metabolism of prions.
The Journal of biological chemistry 2003;278(41):40041-9.
2003: Tony K-K Mong; Lac V Lee; Jillian R Brown; Jeffrey D Esko; Chi-Huey Wong
Synthesis of N-acetyllactosamine derivatives with variation in the aglycon moiety for the study of inhibition of sialyl Lewis x expression.
Chembiochem : a European journal of chemical biology 2003;4(9):835-40.
2003: Jillian R Brown; Mark M Fuster; Thomas Whisenant; Jeffrey D Esko
Expression patterns of alpha 2,3-sialyltransferases and alpha 1,3-fucosyltransferases determine the mode of sialyl Lewis X inhibition by disaccharide decoys.
The Journal of biological chemistry 2003;278(26):23352-9.
2003: Mark M Fuster; Jillian R Brown; Lianchun Wang; Jeffrey D Esko
A disaccharide precursor of sialyl Lewis X inhibits metastatic potential of tumor cells.
Cancer research 2003;63(11):2775-81.
2003: Ho-Yon Hwang; Sara K Olson; Jeffrey D Esko; H Robert Horvitz
Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis.
Nature 2003;423(6938):439-43.
2003: Ho-Yon Hwang; Sara K Olson; Jillian R Brown; Jeffrey D Esko; H Robert Horvitz
The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase.
The Journal of biological chemistry 2003;278(14):11735-8.
2002: Beverly M Zak; Brett E Crawford; Jeffrey D Esko
Hereditary multiple exostoses and heparan sulfate polymerization.
Biochimica et biophysica acta 2002;1573(3):346-55.
2002: Kay Grobe; Johan Ledin; Maria Ringvall; Katarina Holmborn; Erik Forsberg; Jeffrey D Esko; Lena Kjellén
Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes.
Biochimica et biophysica acta 2002;1573(3):209-15.
2002: Miriam Ford-Perriss; Scott E Guimond; Ursula Greferath; Magdalena Kita; Kay Grobe; Hiroko Habuchi; Koji Kimata; Jeffrey D Esko; Mark Murphy; Jeremy E Turnbull
Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.
Glycobiology 2002;12(11):721-7.
2002: Kay Grobe; Jeffrey D Esko
Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites.
The Journal of biological chemistry 2002;277(34):30699-706.
2002: Lianchun Wang; Jillian R Brown; Ajit Varki; Jeffrey D Esko
Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins.
The Journal of clinical investigation 2002;110(1):127-36.
2002: Hiromitsu Yabushita; Yasuyuki Noguchi; Hiroko Habuchi; Satoko Ashikari; Ken Nakabe; Masaru Fujita; Masayoshi Noguchi; Jeffrey D Esko; Koji Kimata
Effects of chemically modified heparin on Chlamydia trachomatis serovar L2 infection of eukaryotic cells in culture.
Glycobiology 2002;12(5):345-51.
2002: Ghiabe H Guibinga; Atsushi Miyanohara; Jeffrey D Esko; Theodore Friedmann
Cell surface heparan sulfate is a receptor for attachment of envelope protein-free retrovirus-like particles and VSV-G pseudotyped MLV-derived retrovirus vectors to target cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(5 Pt 1):538-46.
2002: Mattias Belting; Lubor Borsig; Mark M Fuster; Jillian R Brown; Lo Persson; Lars-Ake Fransson; Jeffrey D Esko
Tumor attenuation by combined heparan sulfate and polyamine depletion.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):371-6.
2002: Jeffrey D Esko; Scott B Selleck
Order out of chaos: assembly of ligand binding sites in heparan sulfate.
Annual review of biochemistry 2002;71():435-71.
2001: Xiaomei Bai; D Zhou; Jillian R Brown; Brett E Crawford; Thierry Hennet; Jeffrey D Esko
Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6).
The Journal of biological chemistry 2001;276(51):48189-95.
2001: M A Pinhal; B Smith; S Olson; J Aikawa; K Kimata; Jeffrey D Esko
Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):12984-9.
2001: Lijuan Zhang; Roger Lawrence; John J Schwartz; X Bai; G Wei; Jeffrey D Esko; R D Rosenberg
The effect of precursor structures on the action of glucosaminyl 3-O-sulfotransferase-1 and the biosynthesis of anticoagulant heparan sulfate.
The Journal of biological chemistry 2001;276(31):28806-13.
2001: X Bai; Jillian R Brown; Ajit Varki; Jeffrey D Esko
Enhanced 3-O-sulfation of galactose in Asn-linked glycans and Maackia amurensis lectin binding in a new Chinese hamster ovary cell line.
Glycobiology 2001;11(8):621-32.
2001: C Pinzon-Ortiz; J Friedman; Jeffrey D Esko; Photini Sinnis
The binding of the circumsporozoite protein to cell surface heparan sulfate proteoglycans is required for plasmodium sporozoite attachment to target cells.
The Journal of biological chemistry 2001;276(29):26784-91.
2001: Jeffrey D Esko; U Lindahl
Molecular diversity of heparan sulfate.
The Journal of clinical investigation 2001;108(2):169-73.
2001: Paul K M Cheung; C McCormick; Brett E Crawford; Jeffrey D Esko; F Tufaro; Gillian Vandermeirsch
Etiological point mutations in the hereditary multiple exostoses gene EXT1: a functional analysis of heparan sulfate polymerase activity.
American journal of human genetics 2001;69(1):55-66.
2001: Brett E Crawford; Sara K Olson; Jeffrey D Esko; M A Pinhal
Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase.
The Journal of biological chemistry 2001;276(24):21538-43.
2001: J Aikawa; Kay Grobe; M Tsujimoto; Jeffrey D Esko
Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4.
The Journal of biological chemistry 2001;276(8):5876-82.
2001: T A Fritz; Jeffrey D Esko
Xyloside priming of glycosaminoglycan biosynthesis and inhibition of proteoglycan assembly.
Methods in molecular biology (Clifton, N.J.) 2001;171():317-23.
2001: X Bai; B Crawford; Jeffrey D Esko
Selection of glycosaminoglycan-deficient mutants.
Methods in molecular biology (Clifton, N.J.) 2001;171():309-16.
2000: AK Sarkar; Jillian R Brown; Jeffrey D Esko
Synthesis and glycan priming activity of acetylated disaccharides.
Carbohydrate research 2000;329(2):287-300.
2000: Dorota A Bulik; G Wei; H Toyoda; A Kinoshita-Toyoda; W R Waldrip; Jeffrey D Esko; Phillips W Robbins; Scott B Selleck
sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10838-43.
2000: Ge Wei; Xiaomei Bai; M M Gabb; K J Bame; T I Koshy; P G Spear; Jeffrey D Esko
Location of the glucuronosyltransferase domain in the heparan sulfate copolymerase EXT1 by analysis of Chinese hamster ovary cell mutants.
The Journal of biological chemistry 2000;275(36):27733-40.
2000: KE Norgard-Sumnicht; X Bai; Jeffrey D Esko; Ajit Varki; A E Manzi
Exploring the outcome of genetic modifications of glycosylation in cultured cell lines by concurrent isolation of the major classes of vertebrate glycans.
Glycobiology 2000;10(7):691-700.
1999: A Sinha; W H Taylor; I H Khan; S T McDaniel; Jeffrey D Esko
Glycoside primers of Psittacanthus cucullaris.
Journal of natural products 1999;62(7):1036-8.
1999: Xiaomei Bai; Ge Wei; A Sinha; Jeffrey D Esko
Chinese hamster ovary cell mutants defective in glycosaminoglycan assembly and glucuronosyltransferase I.
The Journal of biological chemistry 1999;274(19):13017-24.
1999: Ge Wei; Xiaomei Bai; AK Sarkar; Jeffrey D Esko
Formation of HNK-1 determinants and the glycosaminoglycan tetrasaccharide linkage region by UDP-GlcUA:Galactose beta1, 3-glucuronosyltransferases.
The Journal of biological chemistry 1999;274(12):7857-64.
1999: J Aikawa; Jeffrey D Esko
Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family.
The Journal of biological chemistry 1999;274(5):2690-5.
1998: W H Taylor; A Sinha; I A Khan; S T McDaniel; Jeffrey D Esko
Primers of glycosaminoglycan biosynthesis from Peruvian rain forest plants.
The Journal of biological chemistry 1998;273(35):22260-6.
1997: AK Sarkar; K S Rostand; R K Jain; K L Matta; Jeffrey D Esko
Fucosylation of disaccharide precursors of sialyl LewisX inhibit selectin-mediated cell adhesion.
The Journal of biological chemistry 1997;272(41):25608-16.
1997: Xiaomei Bai; K J Bame; Hiroko Habuchi; K Kimata; Jeffrey D Esko
Turnover of heparan sulfate depends on 2-O-sulfation of uronic acids.
The Journal of biological chemistry 1997;272(37):23172-9.
1997: Soren Gantt; P Clavijo; X Bai; Jeffrey D Esko; Photini Sinnis
Cell adhesion to a motif shared by the malaria circumsporozoite protein and thrombospondin is mediated by its glycosaminoglycan-binding region and not by CSVTCG.
The Journal of biological chemistry 1997;272(31):19205-13.
1997: T A Fritz; PK Agrawal; Jeffrey D Esko; NR Krishna
Partial purification and substrate specificity of heparan sulfate alpha-N-acetylglucosaminyltransferase I: synthesis, NMR spectroscopic characterization and in vitro assays of two aryl tetrasaccharides.
Glycobiology 1997;7(5):587-95.
1997: K S Rostand; Jeffrey D Esko
Microbial adherence to and invasion through proteoglycans.
Infection and immunity 1997;65(1):1-8.
1996: F N Lugemwa; A K Sarkar; Jeffrey D Esko
Unusual beta-D-xylosides that prime glycosaminoglycans in animal cells.
The Journal of biological chemistry 1996;271(32):19159-65.
1996: X Bai; Jeffrey D Esko
An animal cell mutant defective in heparan sulfate hexuronic acid 2-O-sulfation.
The Journal of biological chemistry 1996;271(30):17711-7.
1995: A K Sarkar; Jeffrey D Esko
Synthesis and glycosaminoglycan priming activity of three disaccharides related to the linkage region tetrasaccharide of proteoglycans.
Carbohydrate research 1995;279():161-71.
1995: Lijuan Zhang; G David; Jeffrey D Esko
Repetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycans.
The Journal of biological chemistry 1995;270(45):27127-35.
1995: D R Moore; A Smith; K M Hager; R Waldon; Jeffrey D Esko; Stephen L Hajduk
Developmentally regulated sensitivity of Trypanosoma brucei brucei to the cytotoxic effects of human high-density lipoprotein.
Experimental parasitology 1995;81(2):216-26.
1995: Lijuan Zhang; Jeffrey D Esko
Accumulation of a pentasaccharide terminating in alpha-N-acetylglucosamine in an animal cell mutant defective in heparan sulfate biosynthesis.
The Journal of biological chemistry 1995;270(21):12557-62.
1995: A B Smith; Jeffrey D Esko; Stephen L Hajduk
Killing of trypanosomes by the human haptoglobin-related protein.
Science (New York, N.Y.) 1995;268(5208):284-6.
1995: A K Sarkar; T A Fritz; W H Taylor; Jeffrey D Esko
Disaccharide uptake and priming in animal cells: inhibition of sialyl Lewis X by acetylated Gal beta 1-->4GlcNAc beta-O-naphthalenemethanol.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3323-7.
1995: HQ Miao; T A Fritz; Jeffrey D Esko; J Zimmermann; A Yayon; Israel Vlodavsky
Heparan sulfate primed on beta-D-xylosides restores binding of basic fibroblast growth factor.
Journal of cellular biochemistry 1995;57(2):173-84.
1995: E M Tytler; D R Moore; M A Pierce; K M Hager; Jeffrey D Esko; Stephen L Hajduk
Reconstitution of the trypanolytic factor from components of a subspecies of human high-density lipoproteins.
Molecular and biochemical parasitology 1995;69(1):9-17.
1994: T A Fritz; M M Gabb; G Wei; Jeffrey D Esko
Two N-acetylglucosaminyltransferases catalyze the biosynthesis of heparan sulfate.
The Journal of biological chemistry 1994;269(46):28809-14.
1994: K J Bame; Lijuan Zhang; G David; Jeffrey D Esko
Sulphated and undersulphated heparan sulphate proteoglycans in a Chinese hamster ovary cell mutant defective in N-sulphotransferase.
The Biochemical journal 1994;303 ( Pt 1)():81-7.
1994: Lijuan Zhang; Jeffrey D Esko
Amino acid determinants that drive heparan sulfate assembly in a proteoglycan.
The Journal of biological chemistry 1994;269(30):19295-9.
1994: K M Hager; M A Pierce; D R Moore; E M Tytler; Jeffrey D Esko; Stephen L Hajduk
Endocytosis of a cytotoxic human high density lipoprotein results in disruption of acidic intracellular vesicles and subsequent killing of African trypanosomes.
The Journal of cell biology 1994;126(1):155-67.
1994: T A Fritz; F N Lugemwa; A K Sarkar; Jeffrey D Esko
Biosynthesis of heparan sulfate on beta-D-xylosides depends on aglycone structure.
The Journal of biological chemistry 1994;269(1):300-7.
1994: Stephen L Hajduk; K M Hager; Jeffrey D Esko
Human high density lipoprotein killing of African trypanosomes.
Annual review of microbiology 1994;48():139-62.
1993: K S Rostand; Jeffrey D Esko
Cholesterol and cholesterol esters: host receptors for Pseudomonas aeruginosa adherence.
The Journal of biological chemistry 1993;268(32):24053-9.
1993: F N Lugemwa; Jeffrey D Esko
Synthesis of beta-estradiol beta-D-xylopyranosides, primers of heparan sulfate in Chinese hamster ovary cells.
Carbohydrate research 1993;239():285-90.
1992: Rebecca I Montgomery; K Lidholt; N W Flay; J Liang; B Vertel; U Lindahl; Jeffrey D Esko
Stable heparin-producing cell lines derived from the Furth murine mastocytoma.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11327-31.
1992: K Lidholt; J L Weinke; C S Kiser; F N Lugemwa; K J Bame; S Cheifetz; J Massagué; U Lindahl; Jeffrey D Esko
A single mutation affects both N-acetylglucosaminyltransferase and glucuronosyltransferase activities in a Chinese hamster ovary cell mutant defective in heparan sulfate biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2267-71.
1992: Stephen L Hajduk; K Hager; Jeffrey D Esko
High-density lipoprotein-mediated lysis of trypanosomes.
Parasitology today (Personal ed.) 1992;8(3):95-8.
1992: M T Shieh; D WuDunn; Rebecca I Montgomery; Jeffrey D Esko; Patricia G Spear
Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycans.
The Journal of cell biology 1992;116(5):1273-81.
1992: Jeffrey D Esko
Animal cell mutants defective in heparan sulfate polymerization.
Advances in experimental medicine and biology 1992;313():97-106.
1991: K J Bame; R V Reddy; Jeffrey D Esko
Coupling of N-deacetylation and N-sulfation in a Chinese hamster ovary cell mutant defective in heparan sulfate N-sulfotransferase.
The Journal of biological chemistry 1991;266(19):12461-8.
1991: K J Bame; K Lidholt; U Lindahl; Jeffrey D Esko
Biosynthesis of heparan sulfate. Coordination of polymer-modification reactions in a Chinese hamster ovary cell mutant defective in N-sulfotransferase.
The Journal of biological chemistry 1991;266(16):10287-93.
1991: F N Lugemwa; Jeffrey D Esko
Estradiol beta-D-xyloside, an efficient primer for heparan sulfate biosynthesis.
The Journal of biological chemistry 1991;266(11):6674-7.
1990: Jeffrey D Esko; Rebecca I Montgomery; U Lindahl
Secretory heparin in murine mastocytoma cell lines.
Biochemical Society transactions 1990;18(5):807-9.
1989: K J Bame; Jeffrey D Esko
Undersulfated heparan sulfate in a Chinese hamster ovary cell mutant defective in heparan sulfate N-sulfotransferase.
The Journal of biological chemistry 1989;264(14):8059-65.
1989: Stephen L Hajduk; D R Moore; J Vasudevacharya; H Siqueira; A F Torri; E M Tytler; Jeffrey D Esko
Lysis of Trypanosoma brucei by a toxic subspecies of human high density lipoprotein.
The Journal of biological chemistry 1989;264(9):5210-7.
1988: Ada Elgavish; Jeffrey D Esko; A Knurr
Chinese hamster ovary cell mutants deficient in an anion exchanger functionally similar to the erythroid band 3.
The Journal of biological chemistry 1988;263(35):18607-13.
1988: Jeffrey D Esko; K S Rostand; J L Weinke
Tumor formation dependent on proteoglycan biosynthesis.
Science (New York, N.Y.) 1988;241(4869):1092-6.
1987: Jeffrey D Esko; J L Weinke; W H Taylor; G Ekborg; L Rodén; Gm Anantharamaiah; A Gawish
Inhibition of chondroitin and heparan sulfate biosynthesis in Chinese hamster ovary cell mutants defective in galactosyltransferase I.
The Journal of biological chemistry 1987;262(25):12189-95.
1987: U Ludwigs; Ada Elgavish; Jeffrey D Esko; Elias Meezan; L Rodén
Reaction of unsaturated uronic acid residues with mercuric salts. Cleavage of the hyaluronic acid disaccharide 2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-D-glucose.
The Biochemical journal 1987;245(3):795-804.
1986: Jeffrey D Esko; Ada Elgavish; T Prasthofer; W H Taylor; J L Weinke
Sulfate transport-deficient mutants of Chinese hamster ovary cells. Sulfation of glycosaminoglycans dependent on cysteine.
The Journal of biological chemistry 1986;261(33):15725-33.