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James Eskra

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Haiqinq Dai; Stephanie M Gustavson; Gregory M Preston; James D Eskra; Roberto Calle; Boaz Hirshberg
Non-linear increase in GLP-1 levels in response to DPP-IV inhibition in healthy adult subjects.
Kevin D Freeman-Cook; Lawrence A Reiter; Mark C Noe; Amy S Antipas; dennis danley; Kaushik Datta; James T Downs; Shane Eisenbeis; James D Eskra; David J Garmene; Elaine M Greer; Richard J Griffiths; Roberto Guzman; Joel R Hardink; Fouad Janat; Christopher S Jones; Gary J Martinelli; Peter G Mitchell; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Jayvardhan Pandit; Usa D Reilly; Donald Robertson; Marcie L Vaughn-Bowser; Lilli A Wolf-Gouviea; Sue A Yocum
Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
Lawrence A Reiter; Kevin D Freeman-Cook; Christopher S Jones; Gary J Martinelli; Amy S Antipas; Martin A Berliner; Kaushik Datta; James T Downs; James D Eskra; Michael D Forman; Elaine M Greer; Roberto Guzman; Joel R Hardink; Fouad Janat; Nandell F Keene; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Peter G Mitchell; Jayvardhan Pandit; Donald Robertson; Diana Sperger; Marcie L Vaughn-Bowser; Darra M Waller; Sue A Yocum
Potent, selective pyrimidinetrione-based inhibitors of MMP-13.

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All Publications

2008: Haiqinq Dai; Stephanie M Gustavson; Gregory M Preston; James D Eskra; Roberto Calle; Boaz Hirshberg
Non-linear increase in GLP-1 levels in response to DPP-IV inhibition in healthy adult subjects.
Diabetes, obesity & metabolism 2008;10(6):506-13.
2007: Kevin D Freeman-Cook; Lawrence A Reiter; Mark C Noe; Amy S Antipas; dennis danley; Kaushik Datta; James T Downs; Shane Eisenbeis; James D Eskra; David J Garmene; Elaine M Greer; Richard J Griffiths; Roberto Guzman; Joel R Hardink; Fouad Janat; Christopher S Jones; Gary J Martinelli; Peter G Mitchell; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Jayvardhan Pandit; Usa D Reilly; Donald Robertson; Marcie L Vaughn-Bowser; Lilli A Wolf-Gouviea; Sue A Yocum
Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
Bioorganic & medicinal chemistry letters 2007;17(23):6529-34.
2006: Lawrence A Reiter; Kevin D Freeman-Cook; Christopher S Jones; Gary J Martinelli; Amy S Antipas; Martin A Berliner; Kaushik Datta; James T Downs; James D Eskra; Michael D Forman; Elaine M Greer; Roberto Guzman; Joel R Hardink; Fouad Janat; Nandell F Keene; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Peter G Mitchell; Jayvardhan Pandit; Donald Robertson; Diana Sperger; Marcie L Vaughn-Bowser; Darra M Waller; Sue A Yocum
Potent, selective pyrimidinetrione-based inhibitors of MMP-13.
Bioorganic & medicinal chemistry letters 2006;16(22):5822-6.
2005: Catherine E Trebino; James D Eskra; Timothy S Wachtmann; Jose R Perez; Thomas J Carty; Laurent P Audoly
Redirection of eicosanoid metabolism in mPGES-1-deficient macrophages.
The Journal of biological chemistry 2005;280(17):16579-85.
2005: Julian A Blagg; Mark C Noe; Lilli A Wolf-Gouveia; Lawrence A Reiter; Ellen R Laird; Shang-Poa P Chang; dennis danley; James T Downs; Nancy C Elliott; James D Eskra; Richard J Griffiths; Joel R Hardink; Amber I Haugeto; Christopher S Jones; Jennifer L Liras; Lori L Lopresti-Morrow; Peter G Mitchell; Jayvardhan Pandit; Ralph P Robinson; Chakrapani Subramanyam; Marcie L Vaughn-Bowser; Sue A Yocum
Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.
Bioorganic & medicinal chemistry letters 2005;15(7):1807-10.
2004: Lawrence A Reiter; Ralph P Robinson; Kim F McClure; Christopher S Jones; Matthew R Reese; Peter G Mitchell; Ivan G Otterness; Marcia L Bliven; Jennifer L Liras; Santo R Cortina; Kathleen M Donahue; James D Eskra; Richard J Griffiths; Mary E Lame; Arturo Lopez-Anaya; Gary J Martinelli; Shunda M McGahee; Sue A Yocum; Lori L Lopresti-Morrow; Lisa M Tobiassen; Marcie L Vaughn-Bowser
Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1.
Bioorganic & medicinal chemistry letters 2004;14(13):3389-95.
2003: Francis J Sweeney; Timothy S Wachtmann; James D Eskra; Kimberley A Verdries; Ralph H Lambalot; Thomas J Carty; Jose R Perez; Laurent P Audoly
Inhibition of IL-1beta-dependent prostaglandin E2 release by antisense microsomal prostaglandin E synthase 1 oligonucleotides in A549 cells.
Molecular and cellular endocrinology 2003;205(1-2):151-7.
2003: Lawrence A Reiter; Peter G Mitchell; Gary J Martinelli; Lori L Lopresti-Morrow; Sue A Yocum; James D Eskra
Phosphinic acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3.
Bioorganic & medicinal chemistry letters 2003;13(14):2331-6.
2000: Ivan G Otterness; Marcia L Bliven; James D Eskra; Johan teKoppele; Hans A Stukenbrok; Anthony J Milici
Cartilage damage after intraarticular exposure to collagenase 3.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(5):366-73.
1999: John E Burkhardt; James D Eskra; F A Clemo; Ivan G Otterness
Effects of nalidixic acid on hamster knee cartilage morphology and synovial fluid composition.
Toxicologic pathology 1999;27(4):421-6.
1998: Ivan G Otterness; James D Eskra; Marcia L Bliven; A K Shay; J P Pelletier; Anthony J Milici
Exercise protects against articular cartilage degeneration in the hamster.
Arthritis and rheumatism 1998;41(11):2068-76.
1997: Marcia L Bliven; James D Eskra; Ivan G Otterness
Limitation of activity in an acute model of arthritis: effect of drug treatment.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46(12):491-5.
1997: ER Pettipher; James D Eskra; J M Labasi
The inhibitory effect of rolipram on TNF-alpha production in mouse blood ex vivo is dependent upon the release of corticosterone and adrenaline.
Cytokine 1997;9(8):582-6.
1997: Thomas J Carty; Francis J Sweeney; Richard J Griffiths; James D Eskra; M J Ernest; JS Pillar; J D Cheng; L D Loose; P A Joseph; P P Pazoles; Peter F Moore; Atsushi Nagahisa; S Murase; S B Kadin
Tenidap inhibits 5-lipoxygenase product formation in vitro, but this activity is not observed in three animal models.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46(5):168-79.
1997: Richard J Griffiths; MA Smith; Marsha L Roach; Jeffrey L Stock; EJ Stam; Anthony J Milici; DN Scampoli; James D Eskra; Robert S Byrum; Beverly H Koller; John McNeish
Collagen-induced arthritis is reduced in 5-lipoxygenase-activating protein-deficient mice.
The Journal of experimental medicine 1997;185(6):1123-9.
1997: John B Cheng; John W Watson; Chistopher Pazoles; James D Eskra; Richard J Griffiths; Victoria L Cohan; Claudia R Turner; Henry J Showell; ER Pettipher
The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy.
The Journal of pharmacology and experimental therapeutics 1997;280(2):621-6.
1996: P F Moore; D L Larson; Ivan G Otterness; A Weissman; S B Kadin; F J Sweeney; James D Eskra; Atsushi Nagahisa; M Sakakibara; T J Carty
Tenidap, a structurally novel drug for the treatment of arthritis: antiinflammatory and analgesic properties.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1996;45(2):54-61.
1994: Brian J O'connor; S Uden; T J Carty; James D Eskra; Peter J Barnes; K Fan Chung
Inhibitory effect of UK,74505, a potent and specific oral platelet activating factor (PAF) receptor antagonist, on airway and systemic responses to inhaled PAF in humans.
American journal of respiratory and critical care medicine 1994;150(1):35-40.
1991: Ivan G Otterness; H W Golden; P A Seymour; James D Eskra; G O Daumy
Role of prostaglandins in the behavioral changes induced by murine interleukin 1 alpha in the rat.
Cytokine 1991;3(4):333-8.
1991: W D Blackburn; Louis W Heck; L D Loose; James D Eskra; T J Carty
Inhibition of 5-lipoxygenase product formation and polymorphonuclear cell degranulation by tenidap sodium in patients with rheumatoid arthritis.
Arthritis and rheumatism 1991;34(2):204-10.
1988: Ivan G Otterness; Marcia L Bliven; James D Eskra; M Reinke; D C Hanson
The pharmacologic regulation of interleukin-1 production: the role of prostaglandins.
Cellular immunology 1988;114(2):385-97.
1987: F J Sweeney; James D Eskra; M J Ernest; T J Carty
Spectrophotometric monitoring of lipoxygenase and cyclooxygenase pathway activity using ionophore stimulated whole blood.
Agents and actions 1987;21(3-4):393-6.
1987: John B Cheng; James D Eskra; JS Pillar
Comparison of antigen and Ca++-ionophore-induced peptidoleukotriene release from guinea pig lung preparations using high-performance liquid chromatography.
The Journal of pharmacology and experimental therapeutics 1987;241(3):786-92.
1987: F J Sweeney; James D Eskra; T J Carty
Development of a system for evaluating 5-lipoxygenase inhibitors using human whole blood.
Prostaglandins, leukotrienes, and medicine 1987;28(1):73-93.
1987: F J Sweeney; M J Pereira; James D Eskra; T J Carty
The use of 12-hydroxyheptadecatrienoic acid (HHT) as an HPLC/spectrophotometric marker for cyclooxygenase pathway activity in resident rat peritoneal cells.
Prostaglandins, leukotrienes, and medicine 1987;26(3):171-7.
1986: James D Eskra; M J Pereira; M J Ernest
Solid-phase extraction and high-performance liquid chromatography analysis of lipoxygenase pathway products.
Analytical biochemistry 1986;154(1):332-7.
1980: James D Eskra; L Levine; T J Carty
Preparation of [3H]-12-L-hydroxyeicosatetraenoic acid and its use in radioimmunoassay.
Prostaglandins and medicine 1980;5(3):201-7.
1980: T J Carty; James D Eskra; J G Lombardino; W W Hoffman
Piroxicam, a potent inhibitor of prostaglandin production in cell culture. Structure-activity study.
Prostaglandins 1980;19(1):51-9.