FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

William Esler

Research Profile

Chemicals & Drugs

Disorders

Concepts & Ideas

Phenomena

Dimerization

Anatomy

Living Beings

Cricetinae

Co-author Network

Publications

TOP 3
William P Esler; Chittaranjan Das; Michael S Wolfe
Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics.
W Taylor Kimberly; William P Esler; Wenjuan Ye; Beth L Ostaszewski; Jun Gao; Thekla S Diehl; Dennis J Selkoe; Michael S Wolfe
Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
Craig Micchelli; William P Esler; W Taylor Kimberly; Christine Jack; Oksana Berezovska; Anna Y Kornilova; Bradley T Hyman; Norbert Perrimon; Michael S Wolfe
Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of William Esler (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2004: William P Esler; Chittaranjan Das; Michael S Wolfe
Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics.
Bioorganic & medicinal chemistry letters 2004;14(8):1935-8.
2003: W Taylor Kimberly; William P Esler; Wenjuan Ye; Beth L Ostaszewski; Jun Gao; Thekla S Diehl; Dennis J Selkoe; Michael S Wolfe
Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
Biochemistry 2003;42(1):137-44.
2003: Craig Micchelli; William P Esler; W Taylor Kimberly; Christine Jack; Oksana Berezovska; Anna Y Kornilova; Bradley T Hyman; Norbert Perrimon; Michael S Wolfe
Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):79-81.
2002: Michael S Wolfe; William P Esler; Chittaranjan Das
Continuing strategies for inhibiting Alzheimer's gamma-secretase.
Journal of molecular neuroscience : MN 2002;19(1-2):83-7.
2002: William P Esler; Chittaranjan Das; William A Campbell; W Taylor Kimberly; Anna Y Kornilova; Thekla S Diehl; Wenjuan Ye; Beth L Ostaszewski; Weiming Xia; Dennis J Selkoe; Michael S Wolfe
Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase.
Nature cell biology 2002;4(5):E110-1; author reply E111-2.
2002: William P Esler; W Taylor Kimberly; Beth L Ostaszewski; Wenjuan Ye; Thekla S Diehl; Dennis J Selkoe; Michael S Wolfe
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2720-5.
2002: William P Esler; Jeffrey R Marshall; Evelyn R Stimson; Joseph R Ghilardi; Harry V Vinters; Patrick W Mantyh; John E Maggio
Apolipoprotein E affects amyloid formation but not amyloid growth in vitro: mechanistic implications for apoE4 enhanced amyloid burden and risk for Alzheimer's disease.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2002;9(1):1-12.
2001: William P Esler; Michael S Wolfe
A portrait of Alzheimer secretases--new features and familiar faces.
Science (New York, N.Y.) 2001;293(5534):1449-54.
2000: William P Esler; W Taylor Kimberly; Beth L Ostaszewski; Thekla S Diehl; CL Moore; J Y Tsai; T Rahmati; Weiming Xia; Dennis J Selkoe; Michael S Wolfe
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Nature cell biology 2000;2(7):428-34.
2000: William P Esler; AM Felix; Evelyn R Stimson; M J Lachenmann; Joseph R Ghilardi; Y A Lu; Harry V Vinters; Patrick W Mantyh; JP Lee; John E Maggio
Activation barriers to structural transition determine deposition rates of Alzheimer's disease a beta amyloid.
Journal of structural biology 2000;130(2-3):174-83.
2000: William P Esler; Evelyn R Stimson; J M Jennings; Harry V Vinters; Joseph R Ghilardi; JP Lee; Patrick W Mantyh; John E Maggio
Alzheimer's disease amyloid propagation by a template-dependent dock-lock mechanism.
Biochemistry 2000;39(21):6288-95.
1999: B P Tseng; William P Esler; Clary B Clish; Evelyn R Stimson; Joseph R Ghilardi; Harry V Vinters; Patrick W Mantyh; JP Lee; John E Maggio
Deposition of monomeric, not oligomeric, Abeta mediates growth of Alzheimer's disease amyloid plaques in human brain preparations.
Biochemistry 1999;38(32):10424-31.
1999: William P Esler; Evelyn R Stimson; J B Fishman; Joseph R Ghilardi; Harry V Vinters; Patrick W Mantyh; John E Maggio
Stereochemical specificity of Alzheimer's disease beta-peptide assembly.
Biopolymers 1999;49(6):505-14.
1999: William P Esler; Evelyn R Stimson; Patrick W Mantyh; John E Maggio
Deposition of soluble amyloid-beta onto amyloid templates: with application for the identification of amyloid fibril extension inhibitors.
Methods in enzymology 1999;309():350-74.
1998: Derik Weldon; Scott D Rogers; Joseph R Ghilardi; MP Finke; James P Cleary; Eugene O'Hare; William P Esler; John E Maggio; Patrick W Mantyh
Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(6):2161-73.
1997: William P Esler; Evelyn R Stimson; Joseph R Ghilardi; AM Felix; Y A Lu; Harry V Vinters; Patrick W Mantyh; John E Maggio
A beta deposition inhibitor screen using synthetic amyloid.
Nature biotechnology 1997;15(3):258-63.
1996: William P Esler; Evelyn R Stimson; Joseph R Ghilardi; Y A Lu; A M Felix; Harry V Vinters; Patrick W Mantyh; J P Lee; John E Maggio
Point substitution in the central hydrophobic cluster of a human beta-amyloid congener disrupts peptide folding and abolishes plaque competence.
Biochemistry 1996;35(44):13914-21.
1996: William P Esler; Evelyn R Stimson; J M Jennings; Joseph R Ghilardi; Patrick W Mantyh; John E Maggio
Zinc-induced aggregation of human and rat beta-amyloid peptides in vitro.
Journal of neurochemistry 1996;66(2):723-32.
1996: William P Esler; Evelyn R Stimson; Joseph R Ghilardi; Harry V Vinters; J P Lee; Patrick W Mantyh; John E Maggio
In vitro growth of Alzheimer's disease beta-amyloid plaques displays first-order kinetics.
Biochemistry 1996;35(3):749-57.
1995: John E Maggio; William P Esler; Evelyn R Stimson; J M Jennings; Joseph R Ghilardi; Patrick W Mantyh
Zinc and Alzheimer's disease.
Science (New York, N.Y.) 1995;268(5219):1920-1; author reply 1921-3.