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Charles Esmon

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Physiology

Blood Coagulation

Anatomy

Disorders

Inflammation

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequence

Living Beings

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Mice

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Co-Publications
Name
38
Esmon, Naomi
21
Ferrell, Gary
21
Rezaie, AR
15
Kurosawa, Shinichiro
12
Taylor, Fletcher
12
Stearns-Kurosawa, Deborah
12
Smirnov, Mikhail
11
Gu, Jian-Ming
9
safa, omid
8
Comp, Philip
8
Qu, Dongfeng
8
Le Bonniec, BF
7
Mather, T
6
Peer, Glenn
6
Chang, Alvin

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Publications

TOP 3
Chesebro Brian B; Rahn Pamela; Carles Michel; Esmon Charles T; Xu Jun; Brohi Karim; Frith Daniel; Pittet Jean-François; Cohen Mitchell J
Increase in activated protein C mediates acute traumatic coagulopathy in mice.
Xu Jun; Zhang Xiaomei; Pelayo Rosana; Monestier Marc; Ammollo Concetta T; Semeraro Fabrizio; Taylor Fletcher B; Esmon Naomi L; Lupu Florea; Esmon Charles T
Extracellular histones are major mediators of death in sepsis.
Esmon Charles T
Dimorphisms in the membrane-spanning domain of EPCR impact systemic coagulation.

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All Publications

2009: Chesebro Brian B; Rahn Pamela; Carles Michel; Esmon Charles T; Xu Jun; Brohi Karim; Frith Daniel; Pittet Jean-François; Cohen Mitchell J
Increase in activated protein C mediates acute traumatic coagulopathy in mice.
Shock (Augusta, Ga.) 2009;32(6):659-65.
2009: Xu Jun; Zhang Xiaomei; Pelayo Rosana; Monestier Marc; Ammollo Concetta T; Semeraro Fabrizio; Taylor Fletcher B; Esmon Naomi L; Lupu Florea; Esmon Charles T
Extracellular histones are major mediators of death in sepsis.
Nature medicine 2009;15(11):1318-21.
2009: Esmon Charles T
Dimorphisms in the membrane-spanning domain of EPCR impact systemic coagulation.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(11):1712-3.
2009: Esmon Charles T; Glass Jonathan D
The APCs of neuroprotection.
The Journal of clinical investigation 2009;119(11):3205-7.
2009: Edey Matthew M
Thrombomodulin in atypical hemolytic-uremic syndrome.
The New England journal of medicine 2009;361(15):1511; author reply 1511.
2009: Esmon Charles T
Basic mechanisms and pathogenesis of venous thrombosis.
Blood reviews 2009;23(5):225-9.
2009: Nayak Ramesh C; Sen Prosenjit; Ghosh Samit; Gopalakrishnan Ramakrishnan; Esmon Charles T; Pendurthi Usha R; Rao L Vijaya Mohan
Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications.
Blood 2009;114(9):1974-86.
2009: Van Sluis Geerte L; Niers Tatjana M H; Esmon Charles T; Tigchelaar Wikky; Richel Dick J; Buller Harry R; Van Noorden Cornelis J F; Spek C Arnold
Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement.
Blood 2009;114(9):1968-73.
2009: Brooks Erin G; Trotman Winifred; Wadsworth Marilyn P; Taatjes Douglas J; Evans Mark F; Ittleman Frank P; Callas Peter W; Esmon Charles T; Bovill Edwin G
Valves of the deep venous system: an overlooked risk factor.
Blood 2009;114(6):1276-9.
2009: Delvaeye Mieke; Noris Marina; De Vriese Astrid; Esmon Charles T; Esmon Naomi L; Ferrell Gary; Del-Favero Jurgen; Plaisance Stephane; Claes Bart; Lambrechts Diether; Zoja Carla; Remuzzi Giuseppe; Conway Edward M
Thrombomodulin mutations in atypical hemolytic-uremic syndrome.
The New England journal of medicine 2009;361(4):345-57.
2009: Loubele Sarah T B G; Spek C Arnold; Leenders Peter; van Oerle René; Aberson Hella L; Hamulyák Karly; Ferrell Gary; Esmon Charles T; Spronk Henri M H; ten Cate Hugo
Activated protein C protects against myocardial ischemia/ reperfusion injury via inhibition of apoptosis and inflammation.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(7):1087-92.
2009: Finigan James H; Boueiz Adel; Wilkinson Emily; Damico Rachel; Skirball Jarrett; Pae Hyun Hae; Damarla Mahendra; Hasan Emile; Pearse David B; Reddy Sekhar P; Grigoryev Dmitry N; Cheadle Christopher; Esmon Charles T; Garcia Joe G N; Hassoun Paul M
Activated protein C protects against ventilator-induced pulmonary capillary leak.
American journal of physiology. Lung cellular and molecular physiology 2009;296(6):L1002-11.
2009: Xu J; Ji Y; Zhang X; Drake M; Esmon C T
Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock.
Journal of thrombosis and haemostasis : JTH 2009;7(5):851-6.
2009: Izmirly Peter M; Barisoni Laura; Buyon Jill P; Kim Mimi Y; Rivera Tania L; Schwartzman Julie S; Weisstuch Joseph M; Liu David T; Bernstein Stephen; Tseng Chung-E; Belmont Howard M; Esmon Charles T; Merrill Joan T; Askanase Anca D; Thomas David B; Clancy Robert M
Expression of endothelial protein C receptor in cortical peritubular capillaries associates with a poor clinical response in lupus nephritis.
Rheumatology (Oxford, England) 2009;48(5):513-9.
2009: Bezuhly Michael; Cullen Robyn; Esmon Charles T; Morris Steven F; West Kenneth A; Johnston Brent; Liwski Robert S
Role of activated protein C and its receptor in inhibition of tumor metastasis.
Blood 2009;113(14):3371-4.
2009: Looney M R; Esmon C T; Matthay M A
Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury.
Thorax 2009;64(2):114-20.
2008: Esmon Charles T
Crosstalk between inflammation and thrombosis.
Maturitas 2008;61(1-2):122-31.
2008: Yoshida Hideo; Russell Janice; Stokes Karen Y; Yilmaz Cigdem Erkuran; Esmon Charles T; Granger D Neil
Role of the protein C pathway in the extraintestinal thrombosis associated with murine colitis.
Gastroenterology 2008;135(3):882-8.
2008: Saposnik Beatrice; Lesteven Elodie; Lokajczyk Anna; Esmon Charles T; Aiach Martine; Gandrille Sophie
Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma.
Blood 2008;111(7):3442-51.
2008: Li Wei; Adams Ty E; Nangalia Jyoti; Esmon Charles T; Huntington James A
Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(12):4661-6.
2007: Hirsh Jack; Agnelli Giancarlo; Ansell Jack E; Bauer Kenneth A; Esmon Charles T; Turpie Alexander G G
Development of an oral xa inhibitor: rationale and initial clinical results.
Clinical advances in hematology & oncology : H&O 2007;5(12 Suppl 18):1-20.
2007: Isermann Berend; Vinnikov Ilya A; Madhusudhan Thati; Herzog Stefanie; Kashif Muhammed; Blautzik Janusch; Corat Marcus A F; Zeier Martin; Blessing Erwin; Oh Jun; Gerlitz Bruce; Berg David T; Grinnell Brian W; Chavakis Triantafyllos; Esmon Charles T; Weiler Hartmut; Bierhaus Angelika; Nawroth Peter P
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.
Nature medicine 2007;13(11):1349-58.
2007: Silverstein Roy L; Bauer Kenneth A; Cushman Mary; Esmon Charles T; Ershler William B; Tracy Russell P
Venous thrombosis in the elderly: more questions than answers.
Blood 2007;110(9):3097-101.
2007: Borgel Delphine; Bornstain Caroline; Reitsma Pieter H; Lerolle Nicolas; Gandrille Sophie; Dali-Ali Fouad; Esmon Charles T; Fagon Jean-Yves; Aiach Martine; Diehl Jean-Luc
A comparative study of the protein C pathway in septic and nonseptic patients with organ failure.
American journal of respiratory and critical care medicine 2007;176(9):878-85.
2007: Kashiwagi Aki; DiGirolamo Carla M; Kanda Yoshiaki; Niikura Yuichi; Esmon Charles T; Hansen Thomas R; Shioda Toshi; Pru James K
The postimplantation embryo differentially regulates endometrial gene expression and decidualization.
Endocrinology 2007;148(9):4173-84.
2007: Zheng X; Li W; Song Y; Hu Y; Ferrell G L; Esmon N L; Esmon C T
Non-hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia.
Journal of thrombosis and haemostasis : JTH 2007;5(7):1394-400.
2007: Ghosh Samit; Pendurthi Usha R; Steinoe Anne; Esmon Charles T; Rao L Vijaya Mohan
Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium.
The Journal of biological chemistry 2007;282(16):11849-57.
2007: Qu D; Wang Y; Esmon N L; Esmon C T
Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17.
Journal of thrombosis and haemostasis : JTH 2007;5(2):395-402.
2007: Zheng Xunzhen; Li Weihong; Gu Jian-Ming; Qu Dongfeng; Ferrell Gary L; Esmon Naomi L; Esmon Charles T
Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice.
Blood 2007;109(3):1003-9.
2006: Esmon Charles T
The endothelial protein C receptor.
Current opinion in hematology 2006;13(5):382-5.
2006: Esmon Charles T
Inflammation and the activated protein C anticoagulant pathway.
Seminars in thrombosis and hemostasis 2006;32 Suppl 1():49-60.
2006: Balazs Alejandro B; Fabian Attila J; Esmon Charles T; Mulligan Richard C
Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow.
Blood 2006;107(6):2317-21.
2006: Qu D; Wang Y; Song Y; Esmon N L; Esmon C T
The Ser219-->Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype.
Journal of thrombosis and haemostasis : JTH 2006;4(1):229-35.
2005: Esmon Charles T
The interactions between inflammation and coagulation.
British journal of haematology 2005;131(4):417-30.
2005: Li Weihong; Zheng Xunzhen; Gu Jian-Ming; Ferrell Gary L; Brady Mingming; Esmon Naomi L; Esmon Charles T
Extraembryonic expression of EPCR is essential for embryonic viability.
Blood 2005;106(8):2716-22.
2005: Safa Omid; Esmon Charles T; Esmon Naomi L
Inhibition of APC anticoagulant activity on oxidized phospholipid by anti-{beta}2-glycoprotein I monoclonal antibodies.
Blood 2005;106(5):1629-35.
2005: Li W; Zheng X; Gu J; Hunter J; Ferrell G L; Lupu F; Esmon N L; Esmon C T
Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin.
Journal of thrombosis and haemostasis : JTH 2005;3(7):1351-9.
2005: Sesin Carlos A; Yin Xiaoming; Esmon Charles T; Buyon Jill P; Clancy Robert M
Shedding of endothelial protein C receptor contributes to vasculopathy and renal injury in lupus: in vivo and in vitro evidence.
Kidney international 2005;68(1):110-20.
2005: Ludeman Matthew J; Kataoka Hiroshi; Srinivasan Yoga; Esmon Naomi L; Esmon Charles T; Coughlin Shaun R
PAR1 cleavage and signaling in response to activated protein C and thrombin.
The Journal of biological chemistry 2005;280(13):13122-8.
2004: Liaw Patricia C Y; Esmon Charles T; Kahnamoui Kamyar; Schmidt Shelley; Kahnamoui Sarah; Ferrell Gary; Beaudin Suzanne; Julian Jim A; Weitz Jeffrey I; Crowther Mark; Loeb Mark; Cook Deborah
Patients with severe sepsis vary markedly in their ability to generate activated protein C.
Blood 2004;104(13):3958-64.
2004: Esmon Charles T
Interactions between the innate immune and blood coagulation systems.
Trends in immunology 2004;25(10):536-42.
2004: Li Wei; Johnson Daniel J D; Esmon Charles T; Huntington James A
Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.
Nature structural & molecular biology 2004;11(9):857-62.
2004: Esmon Charles T
Structure and functions of the endothelial cell protein C receptor.
Critical care medicine 2004;32(5 Suppl):S298-301.
2004: Esmon Charles T
Why do animal models (sometimes) fail to mimic human sepsis?
Critical care medicine 2004;32(5 Suppl):S219-22.
2004: Esmon Charles T
Crosstalk between inflammation and thrombosis.
Maturitas 2004;47(4):305-14.
2004: Rijneveld Anita W; Weijer Sebastiaan; Florquin Sandrine; Esmon Charles T; Meijers Joost C M; Speelman Peter; Reitsma Pieter H; Ten Cate Hugo; van der Poll Tom
Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide.
Blood 2004;103(5):1702-9.
2004: Esmon C T; Owen W G
The discovery of thrombomodulin.
Journal of thrombosis and haemostasis : JTH 2004;2(2):209-13.
2004: Esmon Charles T
The impact of the inflammatory response on coagulation.
Thrombosis research 2004;114(5-6):321-7.
2003: Esmon Charles T
The protein C pathway.
Chest 2003;124(3 Suppl):26S-32S.
2003: Esmon C T
Inflammation and thrombosis.
Journal of thrombosis and haemostasis : JTH 2003;1(7):1343-8.
2003: Liaw P C Y; Ferrell G; Esmon C T
A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation.
Journal of thrombosis and haemostasis : JTH 2003;1(4):662-70.
2003: Huntington James A; Esmon Charles T
The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form.
Structure (London, England : 1993) 2003;11(4):469-79.
2003: Opal Steven M; Esmon Charles T
Bench-to-bedside review: functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis.
Critical care (London, England) 2003;7(1):23-38.
2003: Esmon Charles T
Coagulation and inflammation.
Journal of endotoxin research 2003;9(3):192-8.
2002: Gu Jian-Ming; Crawley James T B; Ferrell Gary; Zhang Fangjiu; Li Weihong; Esmon Naomi L; Esmon Charles T
Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality.
The Journal of biological chemistry 2002;277(45):43335-43.
2002: Esmon Charles T
New mechanisms for vascular control of inflammation mediated by natural anticoagulant proteins.
The Journal of experimental medicine 2002;196(5):561-4.
2002: Crawley James T B; Gu Jian-Ming; Ferrell Gary; Esmon Charles T
Distribution of endothelial cell protein C/activated protein C receptor (EPCR) during mouse embryo development.
Thrombosis and haemostasis 2002;88(2):259-66.
2002: Baglin Trevor P; Carrell Robin W; Church Frank C; Esmon Charles T; Huntington James A
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11079-84.
2002: Cooper Scott T; Rezaie Alireza R; Esmon Charles T; Church Frank C
Inhibition of a thrombin anion-binding exosite-2 mutant by the glycosaminoglycan-dependent serpins protein C inhibitor and heparin cofactor II.
Thrombosis research 2002;107(1-2):67-73.
2002: Oganesyan Vaheh; Oganesyan Natalia; Terzyan Simon; Qu Dongfeng; Dauter Zbigniew; Esmon Naomi L; Esmon Charles T
The crystal structure of the endothelial protein C receptor and a bound phospholipid.
The Journal of biological chemistry 2002;277(28):24851-4.
2002: Biguzzi Eugenia; Gu Jian-Ming; Merati Giuliana; Esmon Naomi L; Esmon Charles T
Point mutations in the endothelial protein C receptor (EPCR) promoter.
Thrombosis and haemostasis 2002;87(6):1085-6.
2002: Kim Antony Y; Walinsky Peter L; Kolodgie Frank D; Bian Ce; Sperry Jason L; Deming Clayton B; Peck Eric A; Shake Jay G; Ang Gregory B; Sohn Richard H; Esmon Charles T; Virmani Renu; Stuart R Scott; Rade Jeffrey J
Early loss of thrombomodulin expression impairs vein graft thromboresistance: implications for vein graft failure.
Circulation research 2002;90(2):205-12.
2002: Srivastava Arvind; Wang Jianfang; Majumder Rinku; Rezaie Alireza R; Stenflo Johan; Esmon Charles T; Lentz Barry R
Localization of phosphatidylserine binding sites to structural domains of factor Xa.
The Journal of biological chemistry 2002;277(3):1855-63.
2002: Esmon Charles T
Protein C pathway in sepsis.
Annals of medicine 2002;34(7-8):598-605.
2001: Biguzzi E; Merati G; Liaw P C; Bucciarelli P; Oganesyan N; Qu D; Gu J M; Fetiveau R; Esmon C T; Mannucci P M; Faioni E M
A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function.
Thrombosis and haemostasis 2001;86(4):945-8.
2001: Laszik Z G; Zhou X J; Ferrell G L; Silva F G; Esmon C T
Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis.
The American journal of pathology 2001;159(3):797-802.
2001: Wang S X; Esmon C T; Fletterick R J
Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions.
Biochemistry 2001;40(34):10038-46.
2001: Esmon C T
Role of coagulation inhibitors in inflammation.
Thrombosis and haemostasis 2001;86(1):51-6.
2001: Esmon C T
Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation.
Critical care medicine 2001;29(7 Suppl):S48-51; discussion 51-2.
2001: Alberio L; Lämmle B; Esmon C T
Protein C replacement in severe meningococcemia: rationale and clinical experience.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001;32(9):1338-46.
2001: Taylor F B; Peer G T; Lockhart M S; Ferrell G; Esmon C T
Endothelial cell protein C receptor plays an important role in protein C activation in vivo.
Blood 2001;97(6):1685-8.
2001: Liaw P C; Mather T; Oganesyan N; Ferrell G L; Esmon C T
Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor.
The Journal of biological chemistry 2001;276(11):8364-70.
2001: Safa O; Hensley K; Smirnov M D; Esmon C T; Esmon N L
Lipid oxidation enhances the function of activated protein C.
The Journal of biological chemistry 2001;276(3):1829-36.
2001: Esmon C T
The normal role of Activated Protein C in maintaining homeostasis and its relevance to critical illness.
Critical care (London, England) 2001;5(2):S7-12.
2000: Kurosawa S; Esmon C T; Stearns-Kurosawa D J
The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4697-703.
2000: Esmon C
The protein C pathway.
Critical care medicine 2000;28(9 Suppl):S44-8.
2000: Esmon N L; Safa O; Smirnov M D; Esmon C T
Antiphospholipid antibodies and the protein C pathway.
Journal of autoimmunity 2000;15(2):221-5.
2000: Esmon C T
The anticoagulant and anti-inflammatory roles of the protein C anticoagulant pathway.
Journal of autoimmunity 2000;15(2):113-6.
2000: Esmon C T
The endothelial cell protein C receptor.
Thrombosis and haemostasis 2000;83(5):639-43.
2000: Gu J M; Fukudome K; Esmon C T
Characterization and regulation of the 5'-flanking region of the murine endothelial protein C receptor gene.
The Journal of biological chemistry 2000;275(17):12481-8.
2000: Esmon C T
Regulation of blood coagulation.
Biochimica et biophysica acta 2000;1477(1-2):349-60.
2000: Alberio L; Safa O; Clemetson K J; Esmon C T; Dale G L
Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin.
Blood 2000;95(5):1694-702.
2000: Gu J M; Katsuura Y; Ferrell G L; Grammas P; Esmon C T
Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo.
Blood 2000;95(5):1687-93.
2000: Taylor F B; Stearns-Kurosawa D J; Kurosawa S; Ferrell G; Chang A C; Laszik Z; Kosanke S; Peer G; Esmon C T
The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis.
Blood 2000;95(5):1680-6.
2000: Carson C W; Comp P C; Rezaie A R; Esmon N L; Esmon C T
Antibodies to thrombomodulin are found in patients with lupus anticoagulant and unexplained thrombosis.
The Journal of rheumatology 2000;27(2):384-90.
2000: Xu J; Qu D; Esmon N L; Esmon C T
Metalloproteolytic release of endothelial cell protein C receptor.
The Journal of biological chemistry 2000;275(8):6038-44.
2000: Liaw P C; Neuenschwander P F; Smirnov M D; Esmon C T
Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function.
The Journal of biological chemistry 2000;275(8):5447-52.
2000: Esmon C T
Introduction: are natural anticoagulants candidates for modulating the inflammatory response to endotoxin?
Blood 2000;95(4):1113-6.
2000: Esmon C T
Does inflammation contribute to thrombotic events?
Haemostasis 2000;30 Suppl 2():34-40.
1999: Smirnov M D; Safa O; Esmon N L; Esmon C T
Inhibition of activated protein C anticoagulant activity by prothrombin.
Blood 1999;94(11):3839-46.
1999: Esmon C T
Possible involvement of cytokines in diffuse intravascular coagulation and thrombosis.
Baillière's best practice & research. Clinical haematology 1999;12(3):343-59.
1999: Esmon C T; Xu J; Gu J M; Qu D; Laszik Z; Ferrell G; Stearns-Kurosawa D J; Kurosawa S; Taylor F B; Esmon N L
Endothelial protein C receptor.
Thrombosis and haemostasis 1999;82(2):251-8.
1999: Esmon N L; Smirnov M D; Safa O; Esmon C T
Lupus anticoagulants, thrombosis and the protein C system.
Haematologica 1999;84(5):446-51.
1999: Esmon C T; Gu J M; Xu J; Qu D; Stearns-Kurosawa D J; Kurosawa S
Regulation and functions of the protein C anticoagulant pathway.
Haematologica 1999;84(4):363-8.
1999: Esmon C T; Fukudome K; Mather T; Bode W; Regan L M; Stearns-Kurosawa D J; Kurosawa S
Inflammation, sepsis, and coagulation.
Haematologica 1999;84(3):254-9.
1999: Smirnov M D; Ford D A; Esmon C T; Esmon N L
The effect of membrane composition on the hemostatic balance.
Biochemistry 1999;38(12):3591-8.
1999: Xu J; Esmon N L; Esmon C T
Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation.
The Journal of biological chemistry 1999;274(10):6704-10.
1999: Safa O; Morrissey J H; Esmon C T; Esmon N L
Factor VIIa/tissue factor generates a form of factor V with unchanged specific activity, resistance to activation by thrombin, and increased sensitivity to activated protein C.
Biochemistry 1999;38(6):1829-37.
1999: Yegneswaran S; Smirnov M D; Safa O; Esmon N L; Esmon C T; Johnson A E
Relocating the active site of activated protein C eliminates the need for its protein S cofactor. A fluorescence resonance energy transfer study.
The Journal of biological chemistry 1999;274(9):5462-8.
1998: Smirnov M D; Safa O; Regan L; Mather T; Stearns-Kurosawa D J; Kurosawa S; Rezaie A R; Esmon N L; Esmon C T
A chimeric protein C containing the prothrombin Gla domain exhibits increased anticoagulant activity and altered phospholipid specificity.
The Journal of biological chemistry 1998;273(15):9031-40.
1998: Kurosawa S; Stearns-Kurosawa D J; Carson C W; D'Angelo A; Della Valle P; Esmon C T
Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes.
Blood 1998;91(2):725-7.
1998: Rezaie A R; He X; Esmon C T
Thrombomodulin increases the rate of thrombin inhibition by BPTI.
Biochemistry 1998;37(2):693-9.
1997: Laszik Z; Mitro A; Taylor F B; Ferrell G; Esmon C T
Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway.
Circulation 1997;96(10):3633-40.
1997: Regan L M; Mollica J S; Rezaie A R; Esmon C T
The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C.
The Journal of biological chemistry 1997;272(42):26279-84.
1997: Yegneswaran S; Wood G M; Esmon C T; Johnson A E
Protein S alters the active site location of activated protein C above the membrane surface. A fluorescence resonance energy transfer study of topography.
The Journal of biological chemistry 1997;272(40):25013-21.
1997: Esmon N L; Smirnov M D; Esmon C T
Lupus anticoagulants and thrombosis: the role of phospholipids.
Haematologica 1997;82(4):474-7.
1997: He X; Ye J; Esmon C T; Rezaie A R
Influence of Arginines 93, 97, and 101 of thrombin to its functional specificity.
Biochemistry 1997;36(29):8969-76.
1997: Kurosawa S; Stearns-Kurosawa D J; Hidari N; Esmon C T
Identification of functional endothelial protein C receptor in human plasma.
The Journal of clinical investigation 1997;100(2):411-8.
1997: Esmon N L; Smirnov M D; Esmon C T
Thrombogenic mechanisms of antiphospholipid antibodies.
Thrombosis and haemostasis 1997;78(1):79-82.
1997: Esmon C T; Ding W; Yasuhiro K; Gu J M; Ferrell G; Regan L M; Stearns-Kurosawa D J; Kurosawa S; Mather T; Laszik Z; Esmon N L
The protein C pathway: new insights.
Thrombosis and haemostasis 1997;78(1):70-4.
1997: Taylor F B; Coller B S; Chang A C; Peer G; Jordan R; Engellener W; Esmon C T
7E3 F(ab')2, a monoclonal antibody to the platelet GPIIb/IIIa receptor, protects against microangiopathic hemolytic anemia and microvascular thrombotic renal failure in baboons treated with C4b binding protein and a sublethal infusion of Escherichia coli.
Blood 1997;89(11):4078-84.
1997: Houston D S; Carson C W; Esmon C T
Endothelial cells and extracellular calmodulin inhibit monocyte tumor necrosis factor release and augment neutrophil elastase release.
The Journal of biological chemistry 1997;272(18):11778-85.
1996: Rezaie A R; Esmon C T
Molecular basis of residue 192 participation in determination of coagulation protease specificity.
European journal of biochemistry / FEBS 1996;242(3):477-84.
1996: Stearns-Kurosawa D J; Kurosawa S; Mollica J S; Ferrell G L; Esmon C T
The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10212-6.
1996: Fukudome K; Kurosawa S; Stearns-Kurosawa D J; He X; Rezaie A R; Esmon C T
The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor.
The Journal of biological chemistry 1996;271(29):17491-8.
1996: Regan L M; Stearns-Kurosawa D J; Kurosawa S; Mollica J; Fukudome K; Esmon C T
The endothelial cell protein C receptor. Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors.
The Journal of biological chemistry 1996;271(29):17499-503.
1996: Esmon C T; Lollar P
Involvement of thrombin anion-binding exosites 1 and 2 in the activation of factor V and factor VIII.
The Journal of biological chemistry 1996;271(23):13882-7.
1996: Taylor F B; He S E; Chang A C; Box J; Ferrell G; Lee D; Lockhart M; Peer G; Esmon C T
Infusion of phospholipid vesicles amplifies the local thrombotic response to TNF and anti-protein C into a consumptive response.
Thrombosis and haemostasis 1996;75(4):578-84.
1995: Esmon C T; Fukudome K
Cellular regulation of the protein C pathway.
Seminars in cell biology 1995;6(5):259-68.
1995: Taylor F B; Dahlback B; Chang A C; Lockhart M S; Hatanaka K; Peer G; Esmon C T
Role of free protein S and C4b binding protein in regulating the coagulant response to Escherichia coli.
Blood 1995;86(7):2642-52.
1995: Rezaie A R; Cooper S T; Church F C; Esmon C T
Protein C inhibitor is a potent inhibitor of the thrombin-thrombomodulin complex.
The Journal of biological chemistry 1995;270(43):25336-9.
1995: Rezaie A R; Esmon C T
Tryptophans 231 and 234 in protein C report the Ca(2+)-dependent conformational change required for activation by the thrombin-thrombomodulin complex.
Biochemistry 1995;34(38):12221-6.
1995: Esmon C T
Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(10):946-55.
1995: Rezaie A R; Esmon C T
Contribution of residue 192 in factor Xa to enzyme specificity and function.
The Journal of biological chemistry 1995;270(27):16176-81.
1995: Esmon C T
Inflammation. They're not just for clots anymore.
Current biology : CB 1995;5(7):743-6.
1995: Fukudome K; Esmon C T
Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR.
The Journal of biological chemistry 1995;270(10):5571-7.
1995: Esmon C T
Inflammation and thrombosis: the impact of inflammation on the protein C anticoagulant pathway.
Haematologica 1995;80(2 Suppl):49-56.
1995: Smirnov M D; Triplett D T; Comp P C; Esmon N L; Esmon C T
On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies.
The Journal of clinical investigation 1995;95(1):309-16.
1994: Fukudome K; Esmon C T
Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor.
The Journal of biological chemistry 1994;269(42):26486-91.
1994: Esmon C T
Possible involvement of cytokines in diffuse intravascular coagulation and thrombosis.
Baillière's clinical haematology 1994;7(3):453-68.
1994: Rezaie A R; Esmon C T
Asp-70-->Lys mutant of factor X lacks high affinity Ca2+ binding site yet retains function.
The Journal of biological chemistry 1994;269(34):21495-9.
1994: Rezaie A R; Esmon C T
Calcium inhibition of the activation of protein C by thrombin. Role of the P3 and P3' residues.
European journal of biochemistry / FEBS 1994;223(2):575-9.
1994: Ye J; Rezaie A R; Esmon C T
Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101.
The Journal of biological chemistry 1994;269(27):17965-70.
1994: Guinto E R; Ye J; Le Bonniec B F; Esmon C T
Glu192-->Gln substitution in thrombin yields an enzyme that is effectively inhibited by bovine pancreatic trypsin inhibitor and tissue factor pathway inhibitor.
The Journal of biological chemistry 1994;269(28):18395-400.
1994: Laszik Z; Carson C W; Nadasdy T; Johnson L D; Lerner M R; Brackett D J; Esmon C T; Silva F G
Lack of suppressed renal thrombomodulin expression in a septic rat model with glomerular thrombotic microangiopathy.
Laboratory investigation; a journal of technical methods and pathology 1994;70(6):862-7.
1994: Rezaie A R; Esmon C T
Proline at the P2 position in protein C is important for calcium-mediated regulation of protein C activation and secretion.
Blood 1994;83(9):2526-31.
1994: Liu L W; Rezaie A R; Carson C W; Esmon N L; Esmon C T
Occupancy of anion binding exosite 2 on thrombin determines Ca2+ dependence of protein C activation.
The Journal of biological chemistry 1994;269(16):11807-12.
1994: Le Bonniec B F; Betz A; Guinto E R; Esmon C T; Stone S R
Mapping of the thrombin des-ETW conformation by using site-directed mutants of hirudin. Evidence for the induction of nonlocal modifications by mutagenesis.
Biochemistry 1994;33(13):3959-66.
1994: Rezaie A R; Mather T; Sussman F; Esmon C T
Mutation of Glu-80-->Lys results in a protein C mutant that no longer requires Ca2+ for rapid activation by the thrombin-thrombomodulin complex.
The Journal of biological chemistry 1994;269(5):3151-4.
1994: Smirnov M D; Esmon C T
Phosphatidylethanolamine incorporation into vesicles selectively enhances factor Va inactivation by activated protein C.
The Journal of biological chemistry 1994;269(2):816-9.
1993: Le Bonniec B F; Guinto E R; MacGillivray R T; Stone S R; Esmon C T
The role of thrombin's Tyr-Pro-Pro-Trp motif in the interaction with fibrinogen, thrombomodulin, protein C, antithrombin III, and the Kunitz inhibitors.
The Journal of biological chemistry 1993;268(25):19055-61.
1993: Rezaie A R; Esmon C T
Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors.
The Journal of biological chemistry 1993;268(27):19943-8.
1993: Esmon C T
Molecular events that control the protein C anticoagulant pathway.
Thrombosis and haemostasis 1993;70(1):29-35.
1993: Rezaie A R; Neuenschwander P F; Morrissey J H; Esmon C T
Analysis of the functions of the first epidermal growth factor-like domain of factor X.
The Journal of biological chemistry 1993;268(11):8176-80.
1993: Furmaniak-Kazmierczak E; Hu C Y; Esmon C T
Protein S enhances C4b binding protein interaction with neutrophils.
Blood 1993;81(2):405-11.
1993: Esmon C T; Esmon N L; Le Bonniec B F; Johnson A E
Protein C activation.
Methods in enzymology 1993;222():359-85.
1993: Esmon C T
Cell mediated events that control blood coagulation and vascular injury.
Annual review of cell biology 1993;9():1-26.
1992: Rezaie A R; Esmon C T
The function of calcium in protein C activation by thrombin and the thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives.
The Journal of biological chemistry 1992;267(36):26104-9.
1992: Rezaie A R; Fiore M M; Neuenschwander P F; Esmon C T; Morrissey J H
Expression and purification of a soluble tissue factor fusion protein with an epitope for an unusual calcium-dependent antibody.
Protein expression and purification 1992;3(6):453-60.
1992: Le Bonniec B F; Guinto E R; Esmon C T
Interaction of thrombin des-ETW with antithrombin III, the Kunitz inhibitors, thrombomodulin and protein C. Structural link between the autolysis loop and the Tyr-Pro-Pro-Trp insertion of thrombin.
The Journal of biological chemistry 1992;267(27):19341-8.
1992: Esmon C T
New methods may allow answers to old questions in vascular biology.
Thrombosis research 1992;67(3):299-303.
1992: Rezaie A R; Esmon N L; Esmon C T
The high affinity calcium-binding site involved in protein C activation is outside the first epidermal growth factor homology domain.
The Journal of biological chemistry 1992;267(17):11701-4.
1992: Le Bonniec B F; Guinto E R; Esmon C T
The role of calcium ions in factor X activation by thrombin E192Q.
The Journal of biological chemistry 1992;267(10):6970-6.
1992: Guinto E R; Esmon C T; Mann K G; MacGillivray R T
The complete cDNA sequence of bovine coagulation factor V.
The Journal of biological chemistry 1992;267(5):2971-8.
1992: Esmon C T
The protein C anticoagulant pathway.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(2):135-45.
1992: Hung D T; Vu T K; Wheaton V I; Charo I F; Nelken N A; Esmon N; Esmon C T; Coughlin S R
"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure.
The Journal of clinical investigation 1992;89(2):444-50.
1991: Liu L W; Ye J; Johnson A E; Esmon C T
Proteolytic formation of either of the two prothrombin activation intermediates results in formation of a hirugen-binding site.
The Journal of biological chemistry 1991;266(35):23633-6.
1991: Liu L W; Vu T K; Esmon C T; Coughlin S R
The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity.
The Journal of biological chemistry 1991;266(26):16977-80.
1991: Le Bonniec B F; Esmon C T
Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7371-5.
1991: Taylor F B; Chang A C; Peer G T; Mather T; Blick K; Catlett R; Lockhart M S; Esmon C T
DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia coli without preventing shock or organ damage.
Blood 1991;78(2):364-8.
1991: Snow T R; Deal M T; Dickey D T; Esmon C T
Protein C activation following coronary artery occlusion in the in situ porcine heart.
Circulation 1991;84(1):293-9.
1991: Le Bonniec B F; MacGillivray R T; Esmon C T
Thrombin Glu-39 restricts the P'3 specificity to nonacidic residues.
The Journal of biological chemistry 1991;266(21):13796-803.
1991: Taylor F; Chang A; Ferrell G; Mather T; Catlett R; Blick K; Esmon C T
C4b-binding protein exacerbates the host response to Escherichia coli.
Blood 1991;78(2):357-63.
1991: Esmon C T; Johnson A E; Esmon N L
Initiation of the protein C pathway.
Annals of the New York Academy of Sciences 1991;614():30-43.
1991: Taylor F B; Chang A C; Esmon C T; Hinshaw L B
Baboon model of Escherichia coli sepsis: description of its four stages and the role of tumor necrosis factor, tissue factors, and the protein C system in septic shock.
Current studies in hematology and blood transfusion 1991;(58):8-14.
1990: Taylor F B; Esmon C T; Hinshaw L B
Summary of staging mechanism and intervention studies in the baboon model of E. coli sepsis.
The Journal of trauma 1990;30(12 Suppl):S197-203.
1990: Hamilton K K; Hattori R; Esmon C T; Sims P J
Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex.
The Journal of biological chemistry 1990;265(7):3809-14.
1989: Sims P J; Wiedmer T; Esmon C T; Weiss H J; Shattil S J
Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity.
The Journal of biological chemistry 1989;264(29):17049-57.
1989: Esmon C T
The roles of protein C and thrombomodulin in the regulation of blood coagulation.
The Journal of biological chemistry 1989;264(9):4743-6.
1989: Stearns D J; Kurosawa S; Esmon C T
Microthrombomodulin. Residues 310-486 from the epidermal growth factor precursor homology domain of thrombomodulin will accelerate protein C activation.
The Journal of biological chemistry 1989;264(6):3352-6.
1988: D'Angelo A; Vigano-D'Angelo S; Esmon C T; Comp P C
Acquired deficiencies of protein S. Protein S activity during oral anticoagulation, in liver disease, and in disseminated intravascular coagulation.
The Journal of clinical investigation 1988;81(5):1445-54.
1988: Kurosawa S; Stearns D J; Jackson K W; Esmon C T
A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site.
The Journal of biological chemistry 1988;263(13):5993-6.
1988: Faioni E M; Esmon C T; Esmon N L; Mannucci P M
Isolation of an abnormal protein C molecule from the plasma of a patient with thrombotic diathesis.
Blood 1988;71(4):940-6.
1988: Esmon N L; Esmon C T
Protein C and the endothelium.
Seminars in thrombosis and hemostasis 1988;14(2):210-5.
1988: Stearns D J; Kurosawa S; Sims P J; Esmon N L; Esmon C T
The interaction of a Ca2+-dependent monoclonal antibody with the protein C activation peptide region. Evidence for obligatory Ca2+ binding to both antigen and antibody.
The Journal of biological chemistry 1988;263(2):826-32.
1987: Vigano-D'Angelo S; D'Angelo A; Kaufman C E; Sholer C; Esmon C T; Comp P C
Protein S deficiency occurs in the nephrotic syndrome.
Annals of internal medicine 1987;107(1):42-7.
1987: Esmon C T; Taylor F B; Hinshaw L B; Chang A; Comp P C; Ferrell G; Esmon N L
Protein C, isolation and potential use in prevention of thrombosis.
Developments in biological standardization 1987;67():51-7.
1987: Esmon C T; Vigano-D'Angelo S; D'Angelo A; Comp P C
Anticoagulation proteins C and S.
Advances in experimental medicine and biology 1987;214():47-54.
1987: Esmon N L; D'Angelo A; Vigano-D'Angelo S; Esmon C T; Comp P C
Analysis of protein C and protein S in disease states.
Developments in biological standardization 1987;67():75-82.
1986: Vigano D'Angelo S; Comp P C; Esmon C T; D'Angelo A
Relationship between protein C antigen and anticoagulant activity during oral anticoagulation and in selected disease states.
The Journal of clinical investigation 1986;77(2):416-25.
1986: DeBault L E; Esmon N L; Smith G P; Esmon C T
Localization of thrombomodulin antigen in rabbit endothelial cells in culture. An immunofluorescence and immunoelectron microscope study.
Laboratory investigation; a journal of technical methods and pathology 1986;54(2):179-87.
1986: DeBault L E; Esmon N L; Olson J R; Esmon C T
Distribution of the thrombomodulin antigen in the rabbit vasculature.
Laboratory investigation; a journal of technical methods and pathology 1986;54(2):172-8.
1984: Esmon C T; DeBault L; Carroll R C; Comp P C; Esmon N L
Biochemical and physiological aspects of protein c.
La Ricerca in clinica e in laboratorio 1984;14(3):455-68.
1984: DeBault L E; Esmon N L; Esmon C T
The relationship between thrombomodulin expression and cell cycle stages in cultured rabbit endothelial cells.
Cytometry 1984;5(4):386-91.
1983: Esmon N L; Carroll R C; Esmon C T
Thrombomodulin blocks the ability of thrombin to activate platelets.
The Journal of biological chemistry 1983;258(20):12238-42.
1983: Esmon N L; DeBault L E; Esmon C T
Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C.
The Journal of biological chemistry 1983;258(9):5548-53.
1982: Comp P C; Jacocks R M; Ferrell G L; Esmon C T
Activation of protein C in vivo.
The Journal of clinical investigation 1982;70(1):127-34.

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