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Manuel Espinosa

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
37
del Solar, Gloria
9
Acebo, P
9
Nieto, Concha
6
Moscoso, Miriam
6
Grohmann, Elisabeth
6
Kramer, Gabriela
5
Hernández-Arriaga, Ana
5
Khan, Saleem
4
Ruiz-Masó, José
4
Zechner, Ellen
4
Gomis-Rüth, Xavier
4
López, Paloma
4
Ballester, Sara
4
Coll, Miquel
3
Farías, María Eugenia

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Publications

TOP 3
Hernández-Arriaga Ana M; Rubio-Lepe Tania S; Espinosa Manuel; del Solar Gloria
Repressor CopG prevents access of RNA polymerase to promoter and actively dissociates open complexes.
Lorenzo-Díaz Fabián; Espinosa Manuel
Lagging-strand DNA replication origins are required for conjugal transfer of the promiscuous plasmid pMV158.
Lorenzo-Díaz Fabián; Espinosa Manuel
Large-scale filter mating assay for intra- and inter-specific conjugal transfer of the promiscuous plasmid pMV158 in Gram-positive bacteria.

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All Publications

2009: Hernández-Arriaga Ana M; Rubio-Lepe Tania S; Espinosa Manuel; del Solar Gloria
Repressor CopG prevents access of RNA polymerase to promoter and actively dissociates open complexes.
Nucleic acids research 2009;37(14):4799-811.
2009: Lorenzo-Díaz Fabián; Espinosa Manuel
Lagging-strand DNA replication origins are required for conjugal transfer of the promiscuous plasmid pMV158.
Journal of bacteriology 2009;191(3):720-7.
2009: Lorenzo-Díaz Fabián; Espinosa Manuel
Large-scale filter mating assay for intra- and inter-specific conjugal transfer of the promiscuous plasmid pMV158 in Gram-positive bacteria.
Plasmid 2009;61(1):65-70.
2007: Nieto Concha; Cherny Izhack; Khoo Seok Kooi; de Lacoba Mario García; Chan Wai Ting; Yeo Chew Chieng; Gazit Ehud; Espinosa Manuel
The yefM-yoeB toxin-antitoxin systems of Escherichia coli and Streptococcus pneumoniae: functional and structural correlation.
Journal of bacteriology 2007;189(4):1266-78.
2007: Serrano-Heras Gemma; Ruiz-Masó José A; del Solar Gloria; Espinosa Manuel; Bravo Alicia; Salas Margarita
Protein p56 from the Bacillus subtilis phage phi29 inhibits DNA-binding ability of uracil-DNA glycosylase.
Nucleic acids research 2007;35(16):5393-401.
2007: Ruiz-Masó José A; Lurz Rudi; Espinosa Manuel; del Solar Gloria
Interactions between the RepB initiator protein of plasmid pMV158 and two distant DNA regions within the origin of replication.
Nucleic acids research 2007;35(4):1230-44.
2006: Ruiz-Masó J A; Anand S P; Espinosa M; Khan S A; del Solar G
Genetic and biochemical characterization of the Streptococcus pneumoniae PcrA helicase and its role in plasmid rolling circle replication.
Journal of bacteriology 2006;188(21):7416-25.
2006: Nieto Concha; Pellicer Teresa; Balsa Dolors; Christensen Suzanne K; Gerdes Kenn; Espinosa Manuel
The chromosomal relBE2 toxin-antitoxin locus of Streptococcus pneumoniae: characterization and use of a bioluminescence resonance energy transfer assay to detect toxin-antitoxin interaction.
Molecular microbiology 2006;59(4):1280-96.
2005: Letiembre Maryse; Echchannaoui Hakim; Bachmann Philipp; Ferracin Fabrizia; Nieto Concepción; Espinosa Manuel; Landmann Regine
Toll-like receptor 2 deficiency delays pneumococcal phagocytosis and impairs oxidative killing by granulocytes.
Infection and immunity 2005;73(12):8397-401.
2005: Fernandez-Lopez Raul; Machón Cristina; Longshaw Christopher M; Martin Steve; Molin Soren; Zechner Ellen L; Espinosa Manuel; Lanka Erich; de la Cruz Fernando
Unsaturated fatty acids are inhibitors of bacterial conjugation.
Microbiology (Reading, England) 2005;151(Pt 11):3517-26.
2005: Echchannaoui Hakim; Bachmann Philipp; Letiembre Maryse; Espinosa Manuel; Landmann Regine
Regulation of Streptococcus pneumoniae distribution by Toll-like receptor 2 in vivo.
Immunobiology 2005;210(2-4):229-36.
2004: Cybulski Larisa E; del Solar Gloria; Craig Patricio O; Espinosa Manuel; de Mendoza Diego
Bacillus subtilis DesR functions as a phosphorylation-activated switch to control membrane lipid fluidity.
The Journal of biological chemistry 2004;279(38):39340-7.
2004: Ruiz-Masó José A; López-Zumel Consuelo; Menéndez Margarita; Espinosa Manuel; del Solar Gloria
Structural features of the initiator of replication protein RepB encoded by the promiscuous plasmid pMV158.
Biochimica et biophysica acta 2004;1696(1):113-9.
2004: de Antonio Carmen; Farías María Eugenia; de Lacoba Mario García; Espinosa Manuel
Features of the plasmid pMV158-encoded MobM, a protein involved in its mobilization.
Journal of molecular biology 2004;335(3):733-43.
2003: Grohmann Elisabeth; Muth Günther; Espinosa Manuel
Conjugative plasmid transfer in gram-positive bacteria.
Microbiology and molecular biology reviews : MMBR 2003;67(2):277-301, table of contents.
2003: Nieto Concepción; Espinosa Manuel
Construction of the mobilizable plasmid pMV158GFP, a derivative of pMV158 that carries the gene encoding the green fluorescent protein.
Plasmid 2003;49(3):281-5.
2002: del Solar Gloria; Hernández-Arriaga Ana M; Gomis-Rüth F Xavier; Coll Miquel; Espinosa Manuel
A genetically economical family of plasmid-encoded transcriptional repressors involved in control of plasmid copy number.
Journal of bacteriology 2002;184(18):4943-51.
2001: Costa M; Solà M; del Solar G; Eritja R; Hernández-Arriaga A M; Espinosa M; Gomis-Rüth F X; Coll M
Plasmid transcriptional repressor CopG oligomerises to render helical superstructures unbound and in complexes with oligonucleotides.
Journal of molecular biology 2001;310(2):403-17.
2001: Nieto C; Puyet A; Espinosa M
MalR-mediated regulation of the Streptococcus pneumoniae malMP operon at promoter PM. Influence of a proximal divergent promoter region and competition between MalR and RNA polymerase proteins.
The Journal of biological chemistry 2001;276(18):14946-54.
2001: del Solar G; Espinosa M
In vitro analysis of the terminator T(II) of the inhibitor antisense rna II gene from plasmid pMV158.
Plasmid 2001;45(2):75-87.
2000: Farías M E; Espinosa M
Conjugal transfer of plasmid pMV158: uncoupling of the pMV158 origin of transfer from the mobilization gene mobM, and modulation of pMV158 transfer in Escherichia coli mediated by IncP plasmids.
Microbiology (Reading, England) 2000;146 ( Pt 9)():2259-65.
2000: del Solar G; Espinosa M
Plasmid copy number control: an ever-growing story.
Molecular microbiology 2000;37(3):492-500.
2000: Acebo P; Nieto C; Corrales M A; Espinosa M; López P
Quantitative detection of Streptococcus pneumoniae cells harbouring single or multiple copies of the gene encoding the green fluorescent protein.
Microbiology (Reading, England) 2000;146 ( Pt 6)():1267-73.
2000: Nieto C; Fernández de Palencia P; López P; Espinosa M
Construction of a tightly regulated plasmid vector for Streptococcus pneumoniae: controlled expression of the green fluorescent protein.
Plasmid 2000;43(3):205-13.
2000: Fernández de Palencia P; Nieto C; Acebo P; Espinosa M; López P
Expression of green fluorescent protein in Lactococcus lactis.
FEMS microbiology letters 2000;183(2):229-34.
2000: Hernández-Arriaga A M; Espinosa M; del Solar G
A functional lagging strand origin does not stabilize plasmid pMV158 inheritance in Escherichia coli.
Plasmid 2000;43(1):49-58.
1999: Kramer M G; Espinosa M; Misra T K; Khan S A
Characterization of a single-strand origin, ssoU, required for broad host range replication of rolling-circle plasmids.
Molecular microbiology 1999;33(3):466-75.
1999: Farías M E; Grohmann E; Espinosa M
Expression of the mobM gene of the streptococcal plasmid pMV158 in Lactococcus lactis subsp. lactis.
FEMS microbiology letters 1999;176(2):403-10.
1999: Grohmann E; Guzmán L M; Espinosa M
Mobilisation of the streptococcal plasmid pMV158: interactions of MobM protein with its cognate oriT DNA region.
Molecular & general genetics : MGG 1999;261(4-5):707-15.
1998: Gomis-Rüth F X; Solá M; Acebo P; Párraga A; Guasch A; Eritja R; González A; Espinosa M; del Solar G; Coll M
The structure of plasmid-encoded transcriptional repressor CopG unliganded and bound to its operator.
The EMBO journal 1998;17(24):7404-15.
1998: Acebo P; Hernández-Arriaga A M; Kramer M G; Espinosa M; del Solar G
Identification of a new gene in the streptococcal plasmid pLS1: the rnaI gene.
Plasmid 1998;40(3):214-24.
1998: Grohmann E; Moscoso M; Zechner E L; del Solar G; Espinosa M
In vivo definition of the functional origin of leading strand replication on the lactococcal plasmid pFX2.
Molecular & general genetics : MGG 1998;260(1):38-47.
1998: Kramer M G; Espinosa M; Misra T K; Khan S A
Lagging strand replication of rolling-circle plasmids: specific recognition of the ssoA-type origins in different gram-positive bacteria.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10505-10.
1998: Acebo P; García de Lacoba M; Rivas G; Andreu J M; Espinosa M; del Solar G
Structural features of the plasmid pMV158-encoded transcriptional repressor CopG, a protein sharing similarities with both helix-turn-helix and beta-sheet DNA binding proteins.
Proteins 1998;32(2):248-61.
1998: del Solar G; Giraldo R; Ruiz-Echevarría M J; Espinosa M; Díaz-Orejas R
Replication and control of circular bacterial plasmids.
Microbiology and molecular biology reviews : MMBR 1998;62(2):434-64.
1998: Gomis-Rüth F X; Solà M; Pérez-Luque R; Acebo P; Alda M T; González A; Espinosa M; del Solar G; Coll M
Overexpression, purification, crystallization and preliminary X-ray diffraction analysis of the pMV158-encoded plasmid transcriptional repressor protein CopG.
FEBS letters 1998;425(1):161-5.
1998: Kramer M G; Khan S A; Espinosa M
Lagging-strand replication from the ssoA origin of plasmid pMV158 in Streptococcus pneumoniae: in vivo and in vitro influences of mutations in two conserved ssoA regions.
Journal of bacteriology 1998;180(1):83-9.
1997: Nieto C; Espinosa M; Puyet A
The maltose/maltodextrin regulon of Streptococcus pneumoniae. Differential promoter regulation by the transcriptional repressor MalR.
The Journal of biological chemistry 1997;272(49):30860-5.
1997: Kramer M G; Khan S A; Espinosa M
Plasmid rolling circle replication: identification of the RNA polymerase-directed primer RNA and requirement for DNA polymerase I for lagging strand synthesis.
The EMBO journal 1997;16(18):5784-95.
1997: Grohmann E; Zechner E L; Espinosa M
Determination of specific DNA strand discontinuities with nucleotide resolution in exponentionally growing bacteria harboring rolling circle-replicating plasmids.
FEMS microbiology letters 1997;152(2):363-9.
1997: Zechner E L; Prüger H; Grohmann E; Espinosa M; Högenauer G
Specific cleavage of chromosomal and plasmid DNA strands in gram-positive and gram-negative bacteria can be detected with nucleotide resolution.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7435-40.
1997: Moscoso M; Eritja R; Espinosa M
Initiation of replication of plasmid pMV158: mechanisms of DNA strand-transfer reactions mediated by the initiator RepB protein.
Journal of molecular biology 1997;268(5):840-56.
1997: Guzmán L M; Espinosa M
The mobilization protein, MobM, of the streptococcal plasmid pMV158 specifically cleaves supercoiled DNA at the plasmid oriT.
Journal of molecular biology 1997;266(4):688-702.
1997: del Solar G; Acebo P; Espinosa M
Replication control of plasmid pLS1: the antisense RNA II and the compact rnaII region are involved in translational regulation of the initiator RepB synthesis.
Molecular microbiology 1997;23(1):95-108.
1996: del Solar G; Alonso J C; Espinosa M; Díaz-Orejas R
Broad-host-range plasmid replication: an open question.
Molecular microbiology 1996;21(4):661-6.
1996: Acebo P; Alda M T; Espinosa M; del Solar G
Isolation and characterization of pLS1 plasmid mutants with increased copy numbers.
FEMS microbiology letters 1996;140(1):85-91.
1995: del Solar G; Acebo P; Espinosa M
Replication control of plasmid pLS1: efficient regulation of plasmid copy number is exerted by the combined action of two plasmid components, CopG and RNA II.
Molecular microbiology 1995;18(5):913-24.
1995: Moscoso M; del Solar G; Espinosa M
In vitro recognition of the replication origin of pLS1 and of plasmids of the pLS1 family by the RepB initiator protein.
Journal of bacteriology 1995;177(24):7041-9.
1995: Espinosa M; del Solar G; Rojo F; Alonso J C
Plasmid rolling circle replication and its control.
FEMS microbiology letters 1995;130(2-3):111-20.
1995: Kramer M G; del Solar G; Espinosa M
Lagging-strand origins of the promiscuous plasmid pMV158: physical and functional characterization.
Microbiology (Reading, England) 1995;141 ( Pt 3)():655-62.
1995: Moscoso M; del Solar G; Espinosa M
Specific nicking-closing activity of the initiator of replication protein RepB of plasmid pMV158 on supercoiled or single-stranded DNA.
The Journal of biological chemistry 1995;270(8):3772-9.
1994: Pérez-Martín J; Espinosa M
Correlation between DNA bending and transcriptional activation at a plasmid promoter.
Journal of molecular biology 1994;241(1):7-17.
1993: Puyet A; Ibáñez A M; Espinosa M
Characterization of the Streptococcus pneumoniae maltosaccharide regulator MalR, a member of the LacI-GalR family of repressors displaying distinctive genetic features.
The Journal of biological chemistry 1993;268(34):25402-8.
1993: del Solar G; Kramer G; Ballester S; Espinosa M
Replication of the promiscuous plasmid pLS1: a region encompassing the minus origin of replication is associated with stable plasmid inheritance.
Molecular & general genetics : MGG 1993;241(1-2):97-105.
1993: del Solar G; Moscoso M; Espinosa M
Rolling circle-replicating plasmids from gram-positive and gram-negative bacteria: a wall falls.
Molecular microbiology 1993;8(5):789-96.
1993: Puyet A; Espinosa M
Structure of the maltodextrin-uptake locus of Streptococcus pneumoniae. Correlation to the Escherichia coli maltose regulon.
Journal of molecular biology 1993;230(3):800-11.
1993: del Solar G; Moscoso M; Espinosa M
In vivo definition of the functional origin of replication (ori(+)) of the promiscuous plasmid pLS1.
Molecular & general genetics : MGG 1993;237(1-2):65-72.
1992: Pérez-Martín J; Espinosa M
A genetic system to study the in vivo role of transcriptional regulators in Escherichia coli.
Gene 1992;116(1):75-80.
1992: del Solar G; Espinosa M
The copy number of plasmid pLS1 is regulated by two trans-acting plasmid products: the antisense RNA II and the repressor protein, RepA.
Molecular microbiology 1992;6(1):83-94.
1991: Pérez-Martín J; Espinosa M
The RepA repressor can act as a transcriptional activator by inducing DNA bends.
The EMBO journal 1991;10(6):1375-82.
1991: del Solar G; Espinosa M
Labelling DNA ends with the Klenow fragment of the E. coli DNA polymerase I: a cautionary note.
Nucleic acids research 1991;19(8):1956.
1990: del Solar G H; Pérez-Martín J; Espinosa M
Plasmid pLS1-encoded RepA protein regulates transcription from repAB promoter by binding to a DNA sequence containing a 13-base pair symmetric element.
The Journal of biological chemistry 1990;265(21):12569-75.
1990: de la Campa A G; del Solar G H; Espinosa M
Initiation of replication of plasmid pLS1. The initiator protein RepB acts on two distant DNA regions.
Journal of molecular biology 1990;213(2):247-62.
1990: Ballester S; Alonso J C; López P; Espinosa M
Comparative expression of the pC194 cat gene in Streptococcus pneumoniae, Bacillus subtilis and Escherichia coli.
Gene 1990;86(1):71-9.
1989: Pérez-Martín J; del Solar G H; Lurz R; de la Campa A G; Dobrinski B; Espinosa M
Induced bending of plasmid pLS1 DNA by the plasmid-encoded protein RepA.
The Journal of biological chemistry 1989;264(35):21334-9.
1989: Ballester S; Lopez P; Espinosa M; Alonso J C; Lacks S A
Plasmid structural instability associated with pC194 replication functions.
Journal of bacteriology 1989;171(5):2271-7.
1989: del Solar G H; de al Campa A G; Pérez-Martín J; Choli T; Espinosa M
Purification and characterization of RepA, a protein involved in the copy number control of plasmid pLS1.
Nucleic acids research 1989;17(7):2405-20.
1989: Lopez P; Martinez S; Diaz A; Espinosa M; Lacks S A
Characterization of the polA gene of Streptococcus pneumoniae and comparison of the DNA polymerase I it encodes to homologous enzymes from Escherichia coli and phage T7.
The Journal of biological chemistry 1989;264(7):4255-63.
1988: Pérez-Martín J; del Solar G H; de la Campa A G; Espinosa M
Three regions in the DNA of plasmid pLS1 show sequence-directed static bending.
Nucleic acids research 1988;16(19):9113-26.
1988: Puyet A; del Solar G H; Espinosa M
Identification of the origin and direction of replication of the broad-host-range plasmid pLS1.
Nucleic acids research 1988;16(1):115-33.
1987: Martinez S; Lopez P; Espinosa M; Lacks S A
Complementation of Bacillus subtilis polA mutants by DNA polymerase I from Streptococcus pneumoniae.
Molecular & general genetics : MGG 1987;210(2):203-10.
1987: López P; Martinez S; Diaz A; Espinosa M
Streptococcus pneumoniae polA gene is expressed in Escherichia coli and can functionally substitute for the E. coli polA gene.
Journal of bacteriology 1987;169(10):4869-71.
1987: del Solar G H; Puyet A; Espinosa M
Initiation signals for the conversion of single stranded to double stranded DNA forms in the streptococcal plasmid pLS1.
Nucleic acids research 1987;15(14):5561-80.
1986: Ballester S; Lopez P; Alonso J C; Espinosa M; Lacks S A
Selective advantage of deletions enhancing chloramphenicol acetyltransferase gene expression in Streptococcus pneumoniae plasmids.
Gene 1986;41(2-3):153-63.

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