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Ronald Estabrook

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Francesco De Matteis; Ronald W Estabrook; David P Ballou; Minor J Coon; Donovan C Haines
Peroxidase-like activity of uncoupled cytochrome P450: studies with bilirubin and toxicological implications of uncoupling.
Ronald W Estabrook
Honoring Klaus Ruckpaul: remembering the gala party in East Berlin in 1995 celebrating his 65th birthday.
Ronald W Estabrook
A letter to Gordon.

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All Publications

2012: Francesco De Matteis; Ronald W Estabrook; David P Ballou; Minor J Coon; Donovan C Haines
Peroxidase-like activity of uncoupled cytochrome P450: studies with bilirubin and toxicological implications of uncoupling.
Biochemical pharmacology 2012;84(3):374-82.
2011: Ronald W Estabrook
Honoring Klaus Ruckpaul: remembering the gala party in East Berlin in 1995 celebrating his 65th birthday.
Biochimica et biophysica acta 2011;1814(1):6-13.
2009: Ronald W Estabrook
A letter to Gordon.
Xenobiotica; the fate of foreign compounds in biological systems 2009;39(8):558-64.
2007: Tatsuya Kitazume; Donovan Haines; Ronald W Estabrook; Baozhi Chen; Julian A Peterson
Obligatory intermolecular electron-transfer from FAD to FMN in dimeric P450BM-3.
Biochemistry 2007;46(42):11892-901.
2007: Manjunath S Shet; Charles W Fisher; Yves Tremblay; Alain Belanger; Alan J Conley; J Ian Mason; Ronald W Estabrook
Comparison of the 17 alpha-hydroxylase/C17,20-lyase activities of porcine, guinea pig and bovine P450c17 using purified recombinant fusion proteins containing P450c17 linked to NADPH-P450 reductase.
Drug metabolism reviews 2007;39(2-3):289-307.
2006: G V Sergeev; Maxim Chudaev; Ronald W Estabrook; Sergey A Usanov
Expression of outer mitochondrial membrane cytochrome b5 in Escherichia coli. purification of the recombinant protein and studies of its interaction with electron-transfer partners.
Biochemistry. Biokhimii͡a 2006;71(7):790-9.
2006: Ronald W Estabrook
A photographic diary of travels with David Kupfer.
Drug metabolism reviews 2006;38(1-2):23-9.
2005: Ronald W Estabrook
Steroid hydroxylations: a paradigm for cytochrome P450 catalyzed mammalian monooxygenation reactions.
Biochemical and biophysical research communications 2005;338(1):290-8.
2005: T A Bonina; Maxim Chudaev; Ronald W Estabrook; Sergey A Usanov
Engineering of proteolytically stable NADPH-cytochrome P450 reductase.
Biochemistry. Biokhimii͡a 2005;70(3):357-65.
2004: Ronald W Estabrook; Andre Gilip; Oleg Guryev; Sergey A Usanov
Enzymatic phenotyping and evolutionary relatedness of species specific cytochromes P450 17alpha.
Endocrine research 2004;30(4):715.
2004: Ronald W Estabrook
A photo-essay of the life and times of Herbert Remmer with his friends.
Drug metabolism reviews 2004;36(3-4):459-73.
2004: Maxim Chudaev; Ronald W Estabrook; Sergey A Usanov
Chimerogenesis in estimation of specificity and pathway directions for cytochrome p45017alpha catalyzed reactions.
Biochemistry. Biokhimii͡a 2004;69(4):364-75.
2003: Oleg Guryev; Rui A Carvalho; Sergey A Usanov; Maxim Chudaev; Ronald W Estabrook
A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1).
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14754-9.
2003: Ronald W Estabrook
A passion for P450s (rememberances of the early history of research on cytochrome P450).
Drug metabolism and disposition: the biological fate of chemicals 2003;31(12):1461-73.
2003: Jean D Wilson; Richard J Auchus; Michael W Leihy; Oleg Guryev; Ronald W Estabrook; Susan M Osborn; geoffrey shaw; Marilyn Renfree
5alpha-androstane-3alpha,17beta-diol is formed in tammar wallaby pouch young testes by a pathway involving 5alpha-pregnane-3alpha,17alpha-diol-20-one as a key intermediate.
Endocrinology 2003;144(2):575-80.
2003: Maxim Chudaev; Ronald W Estabrook; Sergey A Usanov
Molecular cloning and heterologous expression in E. coli of cytochrome P45017alpha. Comparison of structural and functional properties of substrate-specific cytochromes P450 from different species.
Biochemistry. Biokhimii͡a 2003;68(1):86-98.
2002: Sergey A Usanov; Sandra E Graham; Galina I Lepesheva; Tamara N Azeva; Natalya V Strushkevich; Maxim Chudaev; Ronald W Estabrook; Julian A Peterson
Probing the interaction of bovine cytochrome P450scc (CYP11A1) with adrenodoxin: evaluating site-directed mutations by molecular modeling.
Biochemistry 2002;41(26):8310-20.
2001: Maxim Chudaev; Oleg Guryev; Sergey A Usanov; Ronald W Estabrook
Apo-cytochrome b5 as an indicator of changes in heme accessability: preliminary studies with cytochrome P450 3A4.
Journal of inorganic biochemistry 2001;87(4):237-44.
2001: Maxim Chudaev; Oleg Guryev; Sergey A Usanov; Ronald W Estabrook
An enzymatically active chimeric protein containing the hydrophilic form of NADPH-cytochrome P450 reductase fused to the membrane-binding domain of cytochrome b5.
Biochemical and biophysical research communications 2001;284(4):937-41.
2001: Maxim Chudaev; Oleg Guryev; Sergey A Usanov; Ronald W Estabrook
Expression, purification, and physical properties of recombinant flavocytochrome fusion proteins containing rat cytochrome b(5) linked to NADPH-cytochrome P450 reductase by different membrane-binding segments.
Archives of biochemistry and biophysics 2001;390(2):222-34.
2001: Maxim Chudaev; Oleg Guryev; Sergey A Usanov; Ronald W Estabrook
Reconstitution of the enzymatic activities of cytochrome P450s using recombinant flavocytochromes containing rat cytochrome b(5) fused to NADPH--cytochrome P450 reductase with various membrane-binding segments.
Archives of biochemistry and biophysics 2001;390(2):215-21.
2001: Oleg Guryev; Maxim Chudaev; Sergey A Usanov; Ronald W Estabrook
Interaction of apo-cytochrome b5 with cytochromes P4503A4 and P45017A: relevance of heme transfer reactions.
Biochemistry 2001;40(16):5018-31.
2001: Leslie D Cope; R P Love; S E Guinn; Maxim Chudaev; Sergey A Usanov; Ronald W Estabrook; Z Hrkal; Eric J Hansen
Involvement of HxuC outer membrane protein in utilization of hemoglobin by Haemophilus influenzae.
Infection and immunity 2001;69(4):2353-63.
1999: Ronald W Estabrook
Discovering the functions of cytochrome P450 in drug metabolism: the role of Alfred Hildebrandt.
Drug metabolism reviews 1999;31(2):317-31.
1999: Michel Kranendonk; Filipa Carreira Barbosa; P Theisen; António Laires; Charles W Fisher; Jose Rueff; Ronald W Estabrook; Nico P E Vermeulen
Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies.
Mutation research 1999;441(1):73-83.
1999: Michel Kranendonk; Charles W Fisher; R Roda; Filipa Carreira Barbosa; P Theisen; António Laires; Jose Rueff; Nico P E Vermeulen; Ronald W Estabrook
Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: comparison of three types of expression systems.
Mutation research 1999;439(2):287-300.
1998: Ronald W Estabrook
The role of methods in the discovery of the cytochromes P450.
Methods in molecular biology (Clifton, N.J.) 1998;107():1-13.
1997: Manjunath S Shet; Michael J McPhaul; Charles W Fisher; Nancy R Stallings; Ronald W Estabrook
Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(11):1298-303.
1997: Manjunath S Shet; Charles W Fisher; Ronald W Estabrook
The function of recombinant cytochrome P450s in intact Escherichia coli cells: the 17 alpha-hydroxylation of progesterone and pregnenolone by P450c17.
Archives of biochemistry and biophysics 1997;339(1):218-25.
1996: Ronald W Estabrook; William E Rainey
Twinkle, twinkle little StAR, how we wonder what you are.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13552-4.
1996: Ronald W Estabrook; M S Shet; K Faulkner; Charles W Fisher
The use of electrochemistry for the synthesis of 17 alpha-hydroxyprogesterone by a fusion protein containing P450c17.
Endocrine research 1996;22(4):665-71.
1996: Ronald W Estabrook; M S Shet; Charles W Fisher; C M Jenkins; M R Waterman
The interaction of NADPH-P450 reductase with P450: an electrochemical study of the role of the flavin mononucleotide-binding domain.
Archives of biochemistry and biophysics 1996;333(1):308-15.
1996: M s Shet; Charles W Fisher; P L Holmans; Ronald W Estabrook
The omega-hydroxlyation of lauric acid: oxidation of 12-hydroxlauric acid to dodecanedioic acid by a purified recombinant fusion protein containing P450 4A1 and NADPH-P450 reductase.
Archives of biochemistry and biophysics 1996;330(1):199-208.
1996: Ronald W Estabrook
The remarkable P450s: a historical overview of these versatile hemeprotein catalysts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(2):202-4.
1996: Ronald W Estabrook; K M Faulkner; M S Shet; Charles W Fisher
Application of electrochemistry for P450-catalyzed reactions.
Methods in enzymology 1996;272():44-51.
1996: Charles W Fisher; M S Shet; Ronald W Estabrook
Construction of plasmids and expression in Escherichia coli of enzymatically active fusion proteins containing the heme-domain of a P450 linked to NADPH-P450 reductase.
Methods in enzymology 1996;272():15-25.
1995: K M Faulkner; M S Shet; Charles W Fisher; Ronald W Estabrook
Electrocatalytically driven omega-hydroxylation of fatty acids using cytochrome P450 4A1.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7705-9.
1995: A David Rodrigues; D J Mulford; R D Lee; Bruce W Surber; M J Kukulka; J L Ferrero; S B Thomas; M S Shet; Ronald W Estabrook
In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P4503A4 and NADPH-P450 reductase. Comparison to human liver microsomes and precision-cut liver tissue slices.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(7):765-75.
1995: M S Shet; K M Faulkner; P L Holmans; Charles W Fisher; Ronald W Estabrook
The effects of cytochrome b5, NADPH-P450 reductase, and lipid on the rate of 6 beta-hydroxylation of testosterone as catalyzed by a human P450 3A4 fusion protein.
Archives of biochemistry and biophysics 1995;318(2):314-21.
1994: P L Holmans; M S Shet; C A Martin-Wixtrom; Charles W Fisher; Ronald W Estabrook
The high-level expression in Escherichia coli of the membrane-bound form of human and rat cytochrome b5 and studies on their mechanism of function.
Archives of biochemistry and biophysics 1994;312(2):554-65.
1994: M S Shet; Charles W Fisher; M P Arlotto; C H Shackleton; P L Holmans; C A Martin-Wixtrom; Y Saeki; Ronald W Estabrook
Purification and enzymatic properties of a recombinant fusion protein expressed in Escherichia coli containing the domains of bovine P450 17A and rat NADPH-P450 reductase.
Archives of biochemistry and biophysics 1994;311(2):402-17.
1993: M S Shet; Charles W Fisher; P L Holmans; Ronald W Estabrook
Human cytochrome P450 3A4: enzymatic properties of a purified recombinant fusion protein containing NADPH-P450 reductase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11748-52.
1993: Pieter Swart; Amanda Swart; M R Waterman; Ronald W Estabrook; J I Mason
Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase.
The Journal of clinical endocrinology and metabolism 1993;77(1):98-102.
1993: M S Shet; K Sathasivan; M A Arlotto; M C Mehdy; Ronald W Estabrook
Purification, characterization, and cDNA cloning of an NADPH-cytochrome P450 reductase from mung bean.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2890-4.
1992: Charles W Fisher; M S Shet; D L Caudle; C A Martin-Wixtrom; Ronald W Estabrook
High-level expression in Escherichia coli of enzymatically active fusion proteins containing the domains of mammalian cytochromes P450 and NADPH-P450 reductase flavoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10817-21.
1992: S S Boddupalli; T Oster; Ronald W Estabrook; Julian A Peterson
Reconstitution of the fatty acid hydroxylation function of cytochrome P-450BM-3 utilizing its individual recombinant hemo- and flavoprotein domains.
The Journal of biological chemistry 1992;267(15):10375-80.
1992: Charles W Fisher; D L Caudle; C Martin-Wixtrom; Linda C Quattrochi; R H Tukey; M R Waterman; Ronald W Estabrook
High-level expression of functional human cytochrome P450 1A2 in Escherichia coli.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(2):759-64.
1992: S S Boddupalli; B C Pramanik; C A Slaughter; Ronald W Estabrook; Julian A Peterson
Fatty acid monooxygenation by P450BM-3: product identification and proposed mechanisms for the sequential hydroxylation reactions.
Archives of biochemistry and biophysics 1992;292(1):20-8.
1992: Ronald W Estabrook; J M Trant; Porunelloor A Mathew; J I Mason; M R Waterman
"Designer membranes": construction of a cell containing multiple membrane-bound cytochromes P450.
Current topics in cellular regulation 1992;33():419-31.
1991: A Wada; Porunelloor A Mathew; H J Barnes; D Sanders; Ronald W Estabrook; M R Waterman
Expression of functional bovine cholesterol side chain cleavage cytochrome P450 (P450scc) in Escherichia coli.
Archives of biochemistry and biophysics 1991;290(2):376-80.
1991: Ronald W Estabrook; J I Mason; E R Simpson; J A Peterson; M R Waterman
The heterologous expression of the cytochromes P450: a new approach for the study of enzyme activities and regulation.
Advances in enzyme regulation 1991;31():365-83.
1991: M P Arlotto; J M Trant; Ronald W Estabrook
Measurement of steroid hydroxylation reactions by high-performance liquid chromatography as indicator of P450 identity and function.
Methods in enzymology 1991;206():454-62.
1990: J M Trant; M C Lorence; Eric F Johnson; C H Shackleton; J I Mason; Ronald W Estabrook
Characterization of the steroid-metabolizing capacity of the hepatic cytochrome P450IIC5 expressed in COS-1 cells: 3 beta-hydroxysteroid dehydrogenase/delta 5----4 isomerase type activity.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9756-60.
1990: M C Lorence; J M Trant; B J Clark; B Khyatt; J I Mason; Ronald W Estabrook; M R Waterman
Construction and expression of human/bovine P45017 alpha chimeric proteins: evidence for distinct tertiary structures in the same P450 from two different species.
Biochemistry 1990;29(42):9819-24.
1990: S S Boddupalli; Ronald W Estabrook; Julian A Peterson
Fatty acid monooxygenation by cytochrome P-450BM-3.
The Journal of biological chemistry 1990;265(8):4233-9.
1990: Ronald W Estabrook
Future developments with the cytochromes P-450: promises for the applied chemical and medical sciences.
Biochemical Society transactions 1990;18(1):34-6.
1990: Ronald W Estabrook; L Milewich; Russell A Prough
Cytochrome P-450s as toxicogenic catalysts: the influence of dehydroepiandrosterone.
Princess Takamatsu symposia 1990;21():33-44.
1989: Pieter Swart; Ronald W Estabrook; J I Mason; M R Waterman
Catalytic activity of human and bovine adrenal cytochromes P-450 17 alpha, lyase expressed in Cos 1 cells.
Biochemical Society transactions 1989;17(6):1025-6.
1989: J M McAllister; J F Kerin; J M Trant; Ronald W Estabrook; J I Mason; M R Waterman; Evan R Simpson
Regulation of cholesterol side-chain cleavage and 17 alpha-hydroxylase/lyase activities in proliferating human theca interna cells in long term monolayer culture.
Endocrinology 1989;125(4):1959-66.
1989: M C Lorence; J M Trant; J I Mason; Raman Bhasker; Y Fujii-Kuriyama; Ronald W Estabrook; M R Waterman
Expression of a full-length cDNA encoding bovine adrenal cytochrome P450C21.
Archives of biochemistry and biophysics 1989;273(1):79-88.
1989: H Q Wu; J Masset-Brown; D J Tweedie; L Milewich; R A Frenkel; C Martin-Wixtrom; Ronald W Estabrook; Russell A Prough
Induction of microsomal NADPH-cytochrome P-450 reductase and cytochrome P-450IVA1 (P-450LA omega) by dehydroepiandrosterone in rats: a possible peroxisomal proliferator.
Cancer research 1989;49(9):2337-43.
1989: M R Waterman; J I Mason; M X Zuber; M C Lorence; B J Clark; J M Trant; H J Barnes; Evan R Simpson; Ronald W Estabrook
Expression of P-450 enzyme activities in heterologous cells by transfection.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1989;13():155-63.
1988: Ronald W Estabrook; J I Mason; C Martin-Wixtrom; M Zuber; M R Waterman
Some enzymatic vagaries of a bovine adrenal microsomal cytochrome P-450 introduced and expressed in transformed monkey kidney cells.
Progress in clinical and biological research 1988;274():525-40.
1985: J Capdevila; Y R Kim; C Martin-Wixtrom; John R Falck; S Manna; Ronald W Estabrook
Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450.
Archives of biochemistry and biophysics 1985;243(1):8-19.
1985: M E Spearman; Russell A Prough; Ronald W Estabrook; John R Falck; S Manna; K C Leibman; R C Murphy; J Capdevila
Novel glutathione conjugates formed from epoxyeicosatrienoic acids (EETs).
Archives of biochemistry and biophysics 1985;242(1):225-30.
1983: N Chacos; J Capdevila; John R Falck; S Manna; C Martin-Wixtrom; S S Gill; B D Hammock; Ronald W Estabrook
The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase.
Archives of biochemistry and biophysics 1983;223(2):639-48.
1982: H G Jonen; J Werringloer; R A Prough; Ronald W Estabrook
The reaction of phenylhydrazine with microsomal cytochrome P-450. Catalysis of heme modification.
The Journal of biological chemistry 1982;257(8):4404-11.
1982: J Capdevila; Lawrence J Marnett; N Chacos; R A Prough; Ronald W Estabrook
Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(3):767-70.
1981: J Capdevila; N Chacos; J Werringloer; R A Prough; Ronald W Estabrook
Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(9):5362-6.
1981: J Capdevila; L Parkhill; N Chacos; R Okita; Bettie Sue Masters; Ronald W Estabrook
The oxidative metabolism of arachidonic acid by purified cytochromes P-450.
Biochemical and biophysical research communications 1981;101(4):1357-63.
1981: R Renneberg; J Capdevila; N Chacos; Ronald W Estabrook; R A Prough
Hydrogen peroxide-supported oxidation of benzo [a]pyrene by rat liver microsomal fractions.
Biochemical pharmacology 1981;30(8):843-8.
1980: Ronald W Estabrook; Y Saeki; N Chacos; J Capdevila; R A Prough
Polycyclic hydrocarbon metabolism: a plethora of phenomena.
Advances in enzyme regulation 1980;19():3-17.