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Manel Esteller

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Taniguchi Hiroaki; Fernández Agustin F; Setién Fernando; Ropero Santiago; Ballestar Esteban; Villanueva Alberto; Yamamoto Hiroyuki; Imai Kohzoh; Shinomura Yasuhisa; Esteller Manel
Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.
Urdinguio Rocio G; Sanchez-Mut Jose V; Esteller Manel
Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies.
García-Faroldi Gianni; Correa-Fiz Florencia; Abrighach Hicham; Berdasco María; Fraga Mario F; Esteller Manel; Urdiales José L; Sánchez-Jiménez Francisca; Fajardo Ignacio
Polyamines affect histamine synthesis during early stages of IL-3-induced bone marrow cell differentiation.

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All Publications

2009: Taniguchi Hiroaki; Fernández Agustin F; Setién Fernando; Ropero Santiago; Ballestar Esteban; Villanueva Alberto; Yamamoto Hiroyuki; Imai Kohzoh; Shinomura Yasuhisa; Esteller Manel
Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.
Cancer research 2009;69(21):8447-54.
2009: Urdinguio Rocio G; Sanchez-Mut Jose V; Esteller Manel
Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies.
Lancet neurology 2009;8(11):1056-72.
2009: García-Faroldi Gianni; Correa-Fiz Florencia; Abrighach Hicham; Berdasco María; Fraga Mario F; Esteller Manel; Urdiales José L; Sánchez-Jiménez Francisca; Fajardo Ignacio
Polyamines affect histamine synthesis during early stages of IL-3-induced bone marrow cell differentiation.
Journal of cellular biochemistry 2009;108(1):261-71.
2009: Moncada-Pazos Angela; Obaya Alvaro J; Fraga Mario F; Viloria Cristina G; Capellá Gabriel; Gausachs Mireia; Esteller Manel; López-Otín Carlos; Cal Santiago
The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.
Journal of cell science 2009;122(Pt 16):2906-13.
2009: Davalos Veronica; Esteller Manel
Opening the treasure chest of miR-200s family members.
Cell cycle (Georgetown, Tex.) 2009;8(14):2141-2.
2009: Martinez Ramon; Martin-Subero Jose I; Rohde Veit; Kirsch Matthias; Alaminos Miguel; Fernandez Agustin F; Ropero Santiago; Schackert Gabriele; Esteller Manel
A microarray-based DNA methylation study of glioblastoma multiforme.
Epigenetics : official journal of the DNA Methylation Society 2009;4(4):255-64.
2009: de Silanes Isabel López; Gorospe Myriam; Taniguchi Hiroaki; Abdelmohsen Kotb; Srikantan Subramanya; Alaminos Miguel; Berdasco María; Urdinguio Rocío G; Fraga Mario F; Jacinto Filipe V; Esteller Manel
The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA.
Nucleic acids research 2009;37(8):2658-71.
2009: González-García Sara; García-Peydró Marina; Martín-Gayo Enrique; Ballestar Esteban; Esteller Manel; Bornstein Rafael; de la Pompa José Luis; Ferrando Adolfo A; Toribio María L
CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia.
The Journal of experimental medicine 2009;206(4):779-91.
2009: Guerrero-Preston R; Báez A; Blanco A; Berdasco M; Fraga M; Esteller M
Global DNA methylation: a common early event in oral cancer cases with exposure to environmental carcinogens or viral agents.
Puerto Rico health sciences journal 2009;28(1):24-9.
2009: Melo Sonia A; Ropero Santiago; Moutinho Catia; Aaltonen Lauri A; Yamamoto Hiroyuki; Calin George A; Rossi Simona; Fernandez Agustin F; Carneiro Fatima; Oliveira Carla; Ferreira Bibiana; Liu Chang-Gong; Villanueva Alberto; Capella Gabriel; Schwartz Simo; Shiekhattar Ramin; Esteller Manel
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.
Nature genetics 2009;41(3):365-70.
2009: Teixeira Felipe Karam; Heredia Fabiana; Sarazin Alexis; Roudier François; Boccara Martine; Ciaudo Constance; Cruaud Corinne; Poulain Julie; Berdasco Maria; Fraga Mario F; Voinnet Olivier; Wincker Patrick; Esteller Manel; Colot Vincent
A role for RNAi in the selective correction of DNA methylation defects.
Science (New York, N.Y.) 2009;323(5921):1600-4.
2009: Lujambio Amaia; Esteller Manel
How epigenetics can explain human metastasis: a new role for microRNAs.
Cell cycle (Georgetown, Tex.) 2009;8(3):377-82.
2009: Lara E; Mai A; Calvanese V; Altucci L; Lopez-Nieva P; Martinez-Chantar M L; Varela-Rey M; Rotili D; Nebbioso A; Ropero S; Montoya G; Oyarzabal J; Velasco S; Serrano M; Witt M; Villar-Garea A; Imhof A; Mato J M; Esteller M; Fraga M F
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.
Oncogene 2009;28(6):781-91.
2009: Guil Sònia; Esteller Manel
DNA methylomes, histone codes and miRNAs: tying it all together.
The international journal of biochemistry & cell biology 2009;41(1):87-95.
2009: Aranda Pablo; Agirre Xabier; Ballestar Esteban; Andreu Enrique J; Román-Gómez José; Prieto Inés; Martín-Subero José Ignacio; Cigudosa Juan Cruz; Siebert Reiner; Esteller Manel; Prosper Felipe
Epigenetic signatures associated with different levels of differentiation potential in human stem cells.
PloS one 2009;4(11):e7809.
2009: Wiesmann Frank; Veeck Jürgen; Galm Oliver; Hartmann Arndt; Esteller Manel; Knüchel Ruth; Dahl Edgar
Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer.
Breast cancer research : BCR 2009;11(3):R34.
2009: Berdasco María; Fraga Mario F; Esteller Manel
Quantification of global DNA methylation by capillary electrophoresis and mass spectrometry.
Methods in molecular biology (Clifton, N.J.) 2009;507():23-34.
2008: Segditsas Stefania; Sieber Oliver M; Rowan Andrew; Setien Fernando; Neale Kay; Phillips Robin K S; Ward Robyn; Esteller Manel; Tomlinson Ian P M
Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.
Experimental and molecular pathology 2008;85(3):201-6.
2008: Javierre Biola M; Esteller Manel; Ballestar Esteban
Epigenetic connections between autoimmune disorders and haematological malignancies.
Trends in immunology 2008;29(12):616-23.
2008: Vera E; Canela A; Fraga M F; Esteller M; Blasco M A
Epigenetic regulation of telomeres in human cancer.
Oncogene 2008;27(54):6817-33.
2008: Mulero-Navarro Sonia; Esteller Manel
Epigenetic biomarkers for human cancer: the time is now.
Critical reviews in oncology/hematology 2008;68(1):1-11.
2008: Lujambio Amaia; Calin George A; Villanueva Alberto; Ropero Santiago; Sánchez-Céspedes Montserrat; Blanco David; Montuenga Luis M; Rossi Simona; Nicoloso Milena S; Faller William J; Gallagher William M; Eccles Suzanne A; Croce Carlo M; Esteller Manel
A microRNA DNA methylation signature for human cancer metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(36):13556-61.
2008: Bertolo Cristina; Guerrero David; Vicente Francisco; Cordoba Alicia; Esteller Manel; Ropero Santiago; Guillen-Grima Francisco; Martinez-Peñuela Jose Maria; Lera Jose Miguel
Differences and molecular immunohistochemical parameters in the subtypes of infiltrating ductal breast cancer.
American journal of clinical pathology 2008;130(3):414-24.
2008: José-Enériz Edurne San; Román-Gómez José; Cordeu Lucia; Ballestar Esteban; Gárate Leire; Andreu Enrique J; Isidro Isabel; Guruceaga Elizabeth; Jiménez-Velasco Antonio; Heiniger Anabel; Torres Antonio; Calasanz Maria José; Esteller Manel; Gutiérrez Norma C; Rubio Angel; Pérez-Roger Ignacio; Agirre Xabier; Prósper Felipe
BCR-ABL1-induced expression of HSPA8 promotes cell survival in chronic myeloid leukaemia.
British journal of haematology 2008;142(4):571-82.
2008: Mulero-Navarro Sonia; Esteller Manel
Chromatin remodeling factor CHD5 is silenced by promoter CpG island hypermethylation in human cancer.
Epigenetics : official journal of the DNA Methylation Society 2008;3(4):210-5.
2008: Lopez-Serra L; Esteller M
Proteins that bind methylated DNA and human cancer: reading the wrong words.
British journal of cancer 2008;98(12):1881-5.
2008: Fraga Mario F; Berdasco Maria; Ballestar Esteban; Ropero Santiago; Lopez-Nieva Pilar; Lopez-Serra Lidia; Martín-Subero José I; Calasanz Maria J; Lopez de Silanes Isabel; Setien Fernando; Casado Sara; Fernandez Agustin F; Siebert Reiner; Stifani Stefano; Esteller Manel
Epigenetic inactivation of the Groucho homologue gene TLE1 in hematologic malignancies.
Cancer research 2008;68(11):4116-22.
2008: Gomez-Duran Aurea; Ballestar Esteban; Carvajal-Gonzalez Jose M; Marlowe Jennifer L; Puga Alvaro; Esteller Manel; Fernandez-Salguero Pedro M
Recruitment of CREB1 and histone deacetylase 2 (HDAC2) to the mouse Ltbp-1 promoter regulates its constitutive expression in a dioxin receptor-dependent manner.
Journal of molecular biology 2008;380(1):1-16.
2008: Ropero S; Ballestar E; Alaminos M; Arango D; Schwartz S; Esteller M
Transforming pathways unleashed by a HDAC2 mutation in human cancer.
Oncogene 2008;27(28):4008-12.
2008: Lopez-Serra L; Ballestar E; Ropero S; Setien F; Billard L-M; Fraga M F; Lopez-Nieva P; Alaminos M; Guerrero D; Dante R; Esteller M
Unmasking of epigenetically silenced candidate tumor suppressor genes by removal of methyl-CpG-binding domain proteins.
Oncogene 2008;27(25):3556-66.
2008: Moore Lee E; Pfeiffer Ruth M; Poscablo Cristina; Real Francisco X; Kogevinas Manolis; Silverman Debra; García-Closas Reina; Chanock Stephen; Tardón Adonina; Serra Consol; Carrato Alfredo; Dosemeci Mustafa; García-Closas Montserrat; Esteller Manel; Fraga Mario; Rothman Nathaniel; Malats Núria
Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study.
The lancet oncology 2008;9(4):359-66.
2008: Martínez-Chantar M Luz; Vázquez-Chantada Mercedes; Ariz Usue; Martínez Nuria; Varela Marta; Luka Zigmund; Capdevila Antonieta; Rodríguez Juan; Aransay Ana M; Matthiesen Rune; Yang Heping; Calvisi Diego F; Esteller Manel; Fraga Mario; Lu Shelly C; Wagner Conrad; Mato José M
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.
Hepatology (Baltimore, Md.) 2008;47(4):1191-9.
2008: Esteller Manel
Epigenetics in cancer.
The New England journal of medicine 2008;358(11):1148-59.
2008: Jacinto Filipe V; Ballestar Esteban; Esteller Manel
Methyl-DNA immunoprecipitation (MeDIP): hunting down the DNA methylome.
BioTechniques 2008;44(1):35, 37, 39 passim.
2008: Urdinguio Rocio G; Lopez-Serra Lidia; Lopez-Nieva Pilar; Alaminos Miguel; Diaz-Uriarte Ramon; Fernandez Agustin F; Esteller Manel
Mecp2-null mice provide new neuronal targets for Rett syndrome.
PloS one 2008;3(11):e3669.
2008: Berdasco María; Alcázar Rubén; García-Ortiz María Victoria; Ballestar Esteban; Fernández Agustín F; Roldán-Arjona Teresa; Tiburcio Antonio F; Altabella Teresa; Buisine Nicolas; Quesneville Hadi; Baudry Antoine; Lepiniec Loïc; Alaminos Miguel; Rodríguez Roberto; Lloyd Alan; Colot Vincent; Bender Judith; Canal María Jesús; Esteller Manel; Fraga Mario F
Promoter DNA hypermethylation and gene repression in undifferentiated Arabidopsis cells.
PloS one 2008;3(10):e3306.
2008: Calvanese Vincenzo; Horrillo Angelica; Hmadcha Abdelkrim; Suarez-Alvarez Beatriz; Fernandez Agustín F; Lara Ester; Casado Sara; Menendez Pablo; Bueno Clara; Garcia-Castro Javier; Rubio Ruth; Lapunzina Pablo; Alaminos Miguel; Borghese Lodovica; Terstegge Stefanie; Harrison Neil J; Moore Harry D; Brüstle Oliver; Lopez-Larrea Carlos; Andrews Peter W; Soria Bernat; Esteller Manel; Fraga Mario F
Cancer genes hypermethylated in human embryonic stem cells.
PloS one 2008;3(9):e3294.
2008: Ballestar Esteban; Esteller Manel
Epigenetic gene regulation in cancer.
Advances in genetics 2008;61():247-67.
2007: Jacinto Filipe V; Ballestar Esteban; Ropero Santiago; Esteller Manel
Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells.
Cancer research 2007;67(24):11481-6.
2007: Honrado Emiliano; Osorio Ana; Milne Roger L; Paz María F; Melchor Lorenzo; Cascón Alberto; Urioste Miguel; Cazorla Alicia; Díez Orland; Lerma Enrique; Esteller Manel; Palacios José; Benítez Javier
Immunohistochemical classification of non-BRCA1/2 tumors identifies different groups that demonstrate the heterogeneity of BRCAX families.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007;20(12):1298-306.
2007: Yoshikawa Hirohide; Matsubara Kenichi; Zhou Xiaoling; Okamura Shu; Kubo Takahiko; Murase Yaeko; Shikauchi Yuko; Esteller Manel; Herman James G; Wei Wang Xin; Harris Curtis C
WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer.
Molecular biology of the cell 2007;18(11):4292-303.
2007: Blanco David; Vicent Silvestre; Fraga Mario F; Fernandez-Garcia Ignacio; Freire Javier; Lujambio Amaia; Esteller Manel; Ortiz-de-Solorzano Carlos; Pio Ruben; Lecanda Fernando; Montuenga Luis M
Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway.
Neoplasia (New York, N.Y.) 2007;9(10):840-52.
2007: Aguilera Oscar; Peña Cristina; García José Miguel; Larriba María Jesús; Ordóñez-Morán Paloma; Navarro Diego; Barbáchano Antonio; López de Silanes Isabel; Ballestar Esteban; Fraga Mario F; Esteller Manel; Gamallo Carlos; Bonilla Félix; González-Sancho José Manuel; Muñoz Alberto
The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells.
Carcinogenesis 2007;28(9):1877-84.
2007: Caballero Rosalia; Setien Fernando; Lopez-Serra Lidia; Boix-Chornet Manuel; Fraga Mario F; Ropero Santiago; Megias Diego; Alaminos Miguel; Sanchez-Tapia Eva M; Montoya Maria C; Esteller Manel; Gonzalez-Sarmiento Rogelio; Ballestar Esteban
Combinatorial effects of splice variants modulate function of Aiolos.
Journal of cell science 2007;120(Pt 15):2619-30.
2007: Fraga Mario F; Esteller Manel
Epigenetics and aging: the targets and the marks.
Trends in genetics : TIG 2007;23(8):413-8.
2007: Jacinto Filipe V; Esteller Manel
MGMT hypermethylation: a prognostic foe, a predictive friend.
DNA repair 2007;6(8):1155-60.
2007: Jacinto Filipe V; Esteller Manel
Mutator pathways unleashed by epigenetic silencing in human cancer.
Mutagenesis 2007;22(4):247-53.
2007: Ropero Santiago; Esteller Manel
The role of histone deacetylases (HDACs) in human cancer.
Molecular oncology 2007;1(1):19-25.
2007: Lujambio Amaia; Esteller Manel
CpG island hypermethylation of tumor suppressor microRNAs in human cancer.
Cell cycle (Georgetown, Tex.) 2007;6(12):1455-9.
2007: Martinez Ramon; Setien Fernando; Voelter Christiane; Casado Sara; Quesada Maria P; Schackert Gabriele; Esteller Manel
CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme.
Carcinogenesis 2007;28(6):1264-8.
2007: Poulsen Pernille; Esteller Manel; Vaag Allan; Fraga Mario F
The epigenetic basis of twin discordance in age-related diseases.
Pediatric research 2007;61(5 Pt 2):38R-42R.
2007: Martinez Ramon; Schackert Gabriele; Yaya-Tur Ricard; Rojas-Marcos Iñigo; Herman James G; Esteller Manel
Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme.
Journal of neuro-oncology 2007;83(1):91-3.
2007: Esteller Manel
Epigenetic gene silencing in cancer: the DNA hypermethylome.
Human molecular genetics 2007;16 Spec No 1():R50-9.
2007: Fraga Mario F; Agrelo Ruben; Esteller Manel
Cross-talk between aging and cancer: the epigenetic language.
Annals of the New York Academy of Sciences 2007;1100():60-74.
2007: Esteller Manel
Cancer epigenomics: DNA methylomes and histone-modification maps.
Nature reviews. Genetics 2007;8(4):286-98.
2007: Martinez Ramon; Schackert Gabriele; Esteller Manel
Hypermethylation of the proapoptotic gene TMS1/ASC: prognostic importance in glioblastoma multiforme.
Journal of neuro-oncology 2007;82(2):133-9.
2007: Aguilera Oscar; Muñoz Alberto; Esteller Manel; Fraga Mario F
Epigenetic alterations of the Wnt/beta-catenin pathway in human disease.
Endocrine, metabolic & immune disorders drug targets 2007;7(1):13-21.
2007: Grego-Bessa Joaquín; Luna-Zurita Luis; del Monte Gonzalo; Bolós Victoria; Melgar Pedro; Arandilla Alejandro; Garratt Alistair N; Zang Heesuk; Mukouyama Yoh-Suke; Chen Hanying; Shou Weinian; Ballestar Esteban; Esteller Manel; Rojas Ana; Pérez-Pomares José María; de la Pompa José Luis
Notch signaling is essential for ventricular chamber development.
Developmental cell 2007;12(3):415-29.
2007: Perdiguero Eusebio; Ruiz-Bonilla Vanessa; Gresh Lionel; Hui Lijian; Ballestar Esteban; Sousa-Victor Pedro; Baeza-Raja Bernat; Jardí Mercè; Bosch-Comas Anna; Esteller Manel; Caelles Carme; Serrano Antonio L; Wagner Erwin F; Muñoz-Cánoves Pura
Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation.
The EMBO journal 2007;26(5):1245-56.
2007: Matarazzo M R; De Bonis M L; Strazzullo M; Cerase A; Ferraro M; Vastarelli P; Ballestar E; Esteller M; Kudo S; D'Esposito M
Multiple binding of methyl-CpG and polycomb proteins in long-term gene silencing events.
Journal of cellular physiology 2007;210(3):711-9.
2007: Lujambio Amaia; Ropero Santiago; Ballestar Esteban; Fraga Mario F; Cerrato Celia; Setién Fernando; Casado Sara; Suarez-Gauthier Ana; Sanchez-Cespedes Montserrat; Git Anna; Spiteri Inmaculada; Das Partha P; Caldas Carlos; Miska Eric; Esteller Manel
Genetic unmasking of an epigenetically silenced microRNA in human cancer cells.
Cancer research 2007;67(4):1424-9.
2007: Espada J; Esteller M
Epigenetic control of nuclear architecture.
Cellular and molecular life sciences : CMLS 2007;64(4):449-57.
2007: Urdinguio Rocio G; Pino Irene; Ropero Santiago; Fraga Mario F; Esteller Manel
Histone H3 and H4 modification profiles in a Rett syndrome mouse model.
Epigenetics : official journal of the DNA Methylation Society 2007;2(1):11-4.
2007: Esteller Manel
Rett syndrome: the first forty years: 1966-2006.
Epigenetics : official journal of the DNA Methylation Society 2007;2(1):1.
2007: López de Silanes Isabel; Quesada María Paz; Esteller Manel
Aberrant regulation of messenger RNA 3'-untranslated region in human cancer.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2007;29(1):1-17.
2007: Espada Jesús; Ballestar Esteban; Santoro Raffaella; Fraga Mario F; Villar-Garea Ana; Németh Attila; Lopez-Serra Lidia; Ropero Santiago; Aranda Agustin; Orozco Helena; Moreno Vanessa; Juarranz Angeles; Stockert Juan Carlos; Längst Gernot; Grummt Ingrid; Bickmore Wendy; Esteller Manel
Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells.
Nucleic acids research 2007;35(7):2191-8.
2007: Herranz Michel; Esteller Manel
DNA methylation and histone modifications in patients with cancer: potential prognostic and therapeutic targets.
Methods in molecular biology (Clifton, N.J.) 2007;361():25-62.
2006: Lind G E; Skotheim R I; Fraga M F; Abeler V M; Esteller M; Lothe R A
Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1).
The Journal of pathology 2006;210(4):441-9.
2006: Tang Moying; Torres-Lanzas Juan; Lopez-Rios Fernando; Esteller Manel; Sanchez-Cespedes Montserrat
Wnt signaling promoter hypermethylation distinguishes lung primary adenocarcinomas from colorectal metastasis to the lung.
International journal of cancer. Journal international du cancer 2006;119(11):2603-6.
2006: Rodriguez Jairo; Frigola Jordi; Vendrell Elisenda; Risques Rosa-Ana; Fraga Mario F; Morales Cristina; Moreno Victor; Esteller Manel; Capellà Gabriel; Ribas Maria; Peinado Miguel A
Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers.
Cancer research 2006;66(17):8462-9468.
2006: Lopez-Serra Lidia; Ballestar Esteban; Fraga Mario F; Alaminos Miguel; Setien Fernando; Esteller Manel
A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer.
Cancer research 2006;66(17):8342-6.
2006: Hernández-Vargas Héctor; Ballestar Esteban; Carmona-Saez Pedro; von Kobbe Cayetano; Bañón-Rodríguez Inmaculada; Esteller Manel; Moreno-Bueno Gema; Palacios José
Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53.
International journal of cancer. Journal international du cancer 2006;119(5):1164-75.
2006: Cebrian Arancha; Pharoah Paul D; Ahmed Shahana; Ropero Santiago; Fraga Mario F; Smith Paula L; Conroy Don; Luben Robert; Perkins Barbara; Easton Douglas F; Dunning Alison M; Esteller Manel; Ponder Bruce A J
Genetic variants in epigenetic genes and breast cancer risk.
Carcinogenesis 2006;27(8):1661-9.
2006: Herrmann Jens; Borkham-Kamphorst Erawan; Haas Ute; Van de Leur Eddy; Fraga Mario F; Esteller Manel; Gressner Axel M; Weiskirchen Ralf
The expression of CSRP2 encoding the LIM domain protein CRP2 is mediated by TGF-beta in smooth muscle and hepatic stellate cells.
Biochemical and biophysical research communications 2006;345(4):1526-35.
2006: Aguilera O; Fraga M F; Ballestar E; Paz M F; Herranz M; Espada J; García J M; Muñoz A; Esteller M; González-Sancho J M
Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer.
Oncogene 2006;25(29):4116-21.
2006: Marcé Silvia; Balagué Olga; Colomo Luis; Martinez Antonio; Höller Sylvia; Villamor Neus; Bosch Francesc; Ott German; Rosenwald Andreas; Leoni Lorenzo; Esteller Manel; Fraga Mario F; Montserrat Emili; Colomer Dolors; Campo Elias
Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(12):3754-61.
2006: Ballestar Esteban; Esteller Manel; Richardson Bruce C
The epigenetic face of systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7143-7.
2006: Agrelo Ruben; Cheng Wen-Hsing; Setien Fernando; Ropero Santiago; Espada Jesus; Fraga Mario F; Herranz Michel; Paz Maria F; Sanchez-Cespedes Montserrat; Artiga Maria Jesus; Guerrero David; Castells Antoni; von Kobbe Cayetano; Bohr Vilhelm A; Esteller Manel
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(23):8822-7.
2006: Esteller Manel
The necessity of a human epigenome project.
Carcinogenesis 2006;27(6):1121-5.
2006: Ropero Santiago; Fraga Mario F; Ballestar Esteban; Hamelin Richard; Yamamoto Hiroyuki; Boix-Chornet Manuel; Caballero Rosalia; Alaminos Miguel; Setien Fernando; Paz Maria F; Herranz Michel; Palacios Jose; Arango Diego; Orntoft Torben F; Aaltonen Lauri A; Schwartz Simó; Esteller Manel
A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition.
Nature genetics 2006;38(5):566-9.
2006: Boix-Chornet Manuel; Fraga Mario F; Villar-Garea Ana; Caballero Rosalia; Espada Jesus; Nuñez Antonio; Casado Juan; Largo Cristina; Casal J Ignacio; Cigudosa Juan C; Franco Luis; Esteller Manel; Ballestar Esteban
Release of hypoacetylated and trimethylated histone H4 is an epigenetic marker of early apoptosis.
The Journal of biological chemistry 2006;281(19):13540-7.
2006: Mulero-Navarro S; Carvajal-Gonzalez J M; Herranz M; Ballestar E; Fraga M F; Ropero S; Esteller M; Fernandez-Salguero P M
The dioxin receptor is silenced by promoter hypermethylation in human acute lymphoblastic leukemia through inhibition of Sp1 binding.
Carcinogenesis 2006;27(5):1099-104.
2006: de Yzaguirre M Matabuena; Hernández J Santos; Navarro P Fernández; Nieva P López; Herranz M; Fraga M F; Esteller M; Juarranz A; Fernández-Piqueras J
Epigenetic silencing of E- and N-cadherins in the stroma of mouse thymic lymphomas.
Carcinogenesis 2006;27(5):1081-9.
2006: Herranz Michel; Esteller Manel
New therapeutic targets in cancer: the epigenetic connection.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2006;8(4):242-9.
2006: Gonzalo Susana; Jaco Isabel; Fraga Mario F; Chen Taiping; Li En; Esteller Manel; Blasco María A
DNA methyltransferases control telomere length and telomere recombination in mammalian cells.
Nature cell biology 2006;8(4):416-24.
2006: Castells Antoni; Payá Artemio; Alenda Cristina; Rodríguez-Moranta Francisco; Agrelo Rubén; Andreu Montserrat; Piñol Virgínia; Castellví-Bel Sergi; Jover Rodrigo; Llor Xavier; Pons Elisenda; Elizalde J Ignasi; Bessa Xavier; Alcedo Javier; Saló Joan; Medina Enrique; Naranjo Antonio; Esteller Manel; Piqué Josep M;
Cyclooxygenase 2 expression in colorectal cancer with DNA mismatch repair deficiency.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(6):1686-92.
2006: Hellebrekers Debby M E I; Jair Kam-Wing; Viré Emmanuelle; Eguchi Sayaka; Hoebers Nicole T H; Fraga Mario F; Esteller Manel; Fuks François; Baylin Stephen B; van Engeland Manon; Griffioen Arjan W
Angiostatic activity of DNA methyltransferase inhibitors.
Molecular cancer therapeutics 2006;5(2):467-75.
2006: Viré Emmanuelle; Brenner Carmen; Deplus Rachel; Blanchon Loïc; Fraga Mario; Didelot Céline; Morey Lluis; Van Eynde Aleyde; Bernard David; Vanderwinden Jean-Marie; Bollen Mathieu; Esteller Manel; Di Croce Luciano; de Launoit Yvan; Fuks François
The Polycomb group protein EZH2 directly controls DNA methylation.
Nature 2006;439(7078):871-4.
2006: Herranz Michel; Martín-Caballero Juan; Fraga Mario F; Ruiz-Cabello Jesús; Flores Juana Maria; Desco Manuel; Marquez Victor; Esteller Manel
The novel DNA methylation inhibitor zebularine is effective against the development of murine T-cell lymphoma.
Blood 2006;107(3):1174-7.
2005: Rubio-Moscardo Fanny; Blesa David; Mestre Cinta; Siebert Reiner; Balasas Theo; Benito Adalberto; Rosenwald Andreas; Climent Joan; Martinez Jose I; Schilhabel Markus; Karran E Lorraine; Gesk Stefan; Esteller Manel; deLeeuw Ronald; Staudt Louis M; Fernandez-Luna Jose Luis; Pinkel Daniel; Dyer Martin J S; Martinez-Climent Jose A
Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes.
Blood 2005;106(9):3214-22.
2005: Gallagher William M; Bergin Orla E; Rafferty Mairin; Kelly Zoë D; Nolan Ilse-Maria; Fox Edward J P; Culhane Aedin C; McArdle Linda; Fraga Mario F; Hughes Linda; Currid Caroline A; O'Mahony Fiona; Byrne Aileen; Murphy Alison A; Moss Catherine; McDonnell Susan; Stallings Raymond L; Plumb Jane A; Esteller Manel; Brown Robert; Dervan Peter A; Easty David J
Multiple markers for melanoma progression regulated by DNA methylation: insights from transcriptomic studies.
Carcinogenesis 2005;26(11):1856-67.
2005: Fraga Mario F; Esteller Manel
Towards the human cancer epigenome: a first draft of histone modifications.
Cell cycle (Georgetown, Tex.) 2005;4(10):1377-81.
2005: Galaz Sergio; Espada Jesús; Stockert Juan C; Pacheco María; Sanz-Rodríguez Francisco; Arranz Rocío; Rello Santiago; Cañete Magdalena; Villanueva Angeles; Esteller Manel; Juarranz Angeles
Loss of E-cadherin mediated cell-cell adhesion as an early trigger of apoptosis induced by photodynamic treatment.
Journal of cellular physiology 2005;205(1):86-96.
2005: Fraga Mario F; Ballestar Esteban; Paz Maria F; Ropero Santiago; Setien Fernando; Ballestar Maria L; Heine-Suñer Damia; Cigudosa Juan C; Urioste Miguel; Benitez Javier; Boix-Chornet Manuel; Sanchez-Aguilera Abel; Ling Charlotte; Carlsson Emma; Poulsen Pernille; Vaag Allan; Stephan Zarko; Spector Tim D; Wu Yue-Zhong; Plass Christoph; Esteller Manel
Epigenetic differences arise during the lifetime of monozygotic twins.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10604-9.
2005: Esteller Manel; Almouzni Geneviève
How epigenetics integrates nuclear functions. Workshop on epigenetics and chromatin: transcriptional regulation and beyond.
EMBO reports 2005;6(7):624-8.
2005: Yagüe Jesús; Núñez Antonio; Boix Manuel; Esteller Manel; Alfonso Patricia; Casal J Ignacio
Oxidation of carboxyamidomethyl cysteine may add complexity to protein identification.
Proteomics 2005;5(11):2761-8.
2005: Galm Oliver; Suzuki Hiromu; Akiyama Yoshimitsu; Esteller Manel; Brock Malcolm V; Osieka Rainhardt; Baylin Stephen B; Herman James G
Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies.
Oncogene 2005;24(30):4799-805.
2005: Ballestar Esteban; Esteller Manel
Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2005;83(3):374-84.
2005: Agrelo Ruben; Setien Fernando; Espada Jesus; Artiga Maria Jesus; Rodriguez Maria; Pérez-Rosado Alberto; Sanchez-Aguilera Abel; Fraga Mario F; Piris Miguel Angel; Esteller Manel
Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(17):3940-7.
2005: Espada Jesús; Peinado Héctor; Esteller Manel; Cano Amparo
Direct metabolic regulation of beta-catenin activity by the p85alpha regulatory subunit of phosphoinositide 3-OH kinase.
Experimental cell research 2005;305(2):409-17.
2005: Alaminos Miguel; Dávalos Verónica; Ropero Santiago; Setién Fernando; Paz Maria F; Herranz Michel; Fraga Mario F; Mora Jaume; Cheung Nai-Kong V; Gerald William L; Esteller Manel
EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma.
Cancer research 2005;65(7):2565-71.
2005: Fraga Mario F; Ballestar Esteban; Villar-Garea Ana; Boix-Chornet Manuel; Espada Jesus; Schotta Gunnar; Bonaldi Tiziana; Haydon Claire; Ropero Santiago; Petrie Kevin; Iyer N Gopalakrishna; Pérez-Rosado Alberto; Calvo Enrique; Lopez Juan A; Cano Amparo; Calasanz Maria J; Colomer Dolors; Piris Miguel Angel; Ahn Natalie; Imhof Axel; Caldas Carlos; Jenuwein Thomas; Esteller Manel
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.
Nature genetics 2005;37(4):391-400.
2005: Gonzalo Susana; García-Cao Marta; Fraga Mario F; Schotta Gunnar; Peters Antoine H F M; Cotter Shane E; Eguía Raúl; Dean Douglas C; Esteller Manel; Jenuwein Thomas; Blasco María A
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin.
Nature cell biology 2005;7(4):420-8.
2005: Medina Pedro P; Carretero Julian; Ballestar Esteban; Angulo Barbara; Lopez-Rios Fernando; Esteller Manel; Sanchez-Cespedes Montserrat
Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells.
Human molecular genetics 2005;14(7):973-82.
2005: Lluís Frederic; Ballestar Esteban; Suelves Mònica; Esteller Manel; Muñoz-Cánoves Pura
E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription.
The EMBO journal 2005;24(5):974-84.
2005: Alvarez Sara; Diaz-Uriarte Ramon; Osorio Ana; Barroso Alicia; Melchor Lorenzo; Paz Maria Fe; Honrado Emiliano; Rodríguez Raquel; Urioste Miguel; Valle Laura; Díez Orland; Cigudosa Juan Cruz; Dopazo Joaquin; Esteller Manel; Benitez Javier
A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(3):1146-53.
2005: Lind Guro E; Skotheim Rolf I; Fraga Mario F; Abeler Vera M; Henrique Rui; Saatcioglu Fahri; Esteller Manel; Teixeira Manuel R; Lothe Ragnhild A
The loss of NKX3.1 expression in testicular--and prostate--cancers is not caused by promoter hypermethylation.
Molecular cancer 2005;4(1):8.
2005: Esteller Manel
Dormant hypermethylated tumour suppressor genes: questions and answers.
The Journal of pathology 2005;205(2):172-80.
2005: Esteller Manel
DNA methylation and cancer therapy: new developments and expectations.
Current opinion in oncology 2005;17(1):55-60.
2005: Frigola Jordi; Solé Xavier; Paz Maria F; Moreno Victor; Esteller Manel; Capellà Gabriel; Peinado Miguel A
Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer.
Human molecular genetics 2005;14(2):319-26.
2005: Ballestar Esteban; Ropero Santiago; Alaminos Miguel; Armstrong Judith; Setien Fernando; Agrelo Ruben; Fraga Mario F; Herranz Michel; Avila Sonia; Pineda Mercedes; Monros Eugenia; Esteller Manel
The impact of MECP2 mutations in the expression patterns of Rett syndrome patients.
Human genetics 2005;116(1-2):91-104.
2005: Tort F; Hernández S; Beà S; Camacho E; Fernández V; Esteller M; Fraga M F; Burek C; Rosenwald A; Hernández L; Campo E
Checkpoint kinase 1 (CHK1) protein and mRNA expression is downregulated in aggressive variants of human lymphoid neoplasms.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2005;19(1):112-7.
2005: Ballestar Esteban; Esteller Manel
The epigenetic breakdown of cancer cells: from DNA methylation to histone modifications.
Progress in molecular and subcellular biology 2005;38():169-81.
2005: Esteller Manel
Aberrant DNA methylation as a cancer-inducing mechanism.
Annual review of pharmacology and toxicology 2005;45():629-56.
2004: Sánchez-Beato Margarita; Sánchez Esther; García Juan F; Pérez-Rosado Alberto; Montoya María C; Fraga Mario; Artiga M Jesús; Navarrete Mercedes; Abraira Víctor; Morente Manuel; Esteller Manel; Koseki Haruhiko; Vidal Miguel; Piris Miguel A
Abnormal PcG protein expression in Hodgkin's lymphoma. Relation with E2F6 and NFkappaB transcription factors.
The Journal of pathology 2004;204(5):528-37.
2004: Gallardo Fernando; Esteller Manel; Pujol Ramon M; Costa Carlota; Estrach Teresa; Servitje Octavio
Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas.
Haematologica 2004;89(11):1401-3.
2004: Ropero Santiago; Setien Fernando; Espada Jesus; Fraga Mario F; Herranz Michel; Asp Julia; Benassi Maria Serena; Franchi Alessandro; Patiño Ana; Ward Laura S; Bovee Judith; Cigudosa Juan C; Wim Wuyts; Esteller Manel
Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells.
Human molecular genetics 2004;13(22):2753-65.
2004: Irimia Manuel; Fraga Mario F; Sanchez-Cespedes Montserrat; Esteller Manel
CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer.
Oncogene 2004;23(53):8695-9.
2004: Villar-Garea Ana; Esteller Manel
Histone deacetylase inhibitors: understanding a new wave of anticancer agents.
International journal of cancer. Journal international du cancer 2004;112(2):171-8.
2004: Matarazzo Maria Rosaria; Lembo Francesca; Angrisano Tiziana; Ballestar Esteban; Ferraro Marcella; Pero Raffaela; De Bonis Maria Luigia; Bruni Carmelo Bruno; Esteller Manel; D'Esposito Maurizio; Chiariotti Lorenzo
In vivo analysis of DNA methylation patterns recognized by specific proteins: coupling CHIP and bisulfite analysis.
BioTechniques 2004;37(4):666-8, 670, 672-3.
2004: Lind Guro E; Thorstensen Lin; Løvig Tone; Meling Gunn I; Hamelin Richard; Rognum Torleiv O; Esteller Manel; Lothe Ragnhild A
A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines.
Molecular cancer 2004;3():28.
2004: Medina Pedro P; Carretero Julian; Fraga Mario F; Esteller Manel; Sidransky David; Sanchez-Cespedes Montserrat
Genetic and epigenetic screening for gene alterations of the chromatin-remodeling factor, SMARCA4/BRG1, in lung tumors.
Genes, chromosomes & cancer 2004;41(2):170-7.
2004: Ibanez de Caceres Inmaculada; Battagli Cristina; Esteller Manel; Herman James G; Dulaimi Essel; Edelson Mitchell I; Bergman Cynthia; Ehya Hormoz; Eisenberg Burton L; Cairns Paul
Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients.
Cancer research 2004;64(18):6476-81.
2004: Galm Oliver; Esteller Manel
Beyond genetics--the emerging role of epigenetic changes in hematopoietic malignancies.
International journal of hematology 2004;80(2):120-7.
2004: Alaminos Miguel; Davalos Veronica; Cheung Nai-Kong V; Gerald William L; Esteller Manel
Clustering of gene hypermethylation associated with clinical risk groups in neuroblastoma.
Journal of the National Cancer Institute 2004;96(16):1208-19.
2004: Fraga Mario F; Herranz Michel; Espada Jesús; Ballestar Esteban; Paz Maria F; Ropero Santiago; Erkek Emel; Bozdogan Onder; Peinado Héctor; Niveleau Alain; Mao Jian-Hua; Balmain Alan; Cano Amparo; Esteller Manel
A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors.
Cancer research 2004;64(16):5527-34.
2004: Paz Maria F; Yaya-Tur Ricard; Rojas-Marcos Iñigo; Reynes Gaspar; Pollan Marina; Aguirre-Cruz Lucinda; García-Lopez Jose Luis; Piquer Jose; Safont María-Jose; Balaña Carmen; Sanchez-Cespedes Montserrat; García-Villanueva Mercedes; Arribas Leoncio; Esteller Manel
CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(15):4933-8.
2004: Espada Jesus; Ballestar Esteban; Fraga Mario F; Villar-Garea Ana; Juarranz Angeles; Stockert Juan C; Robertson Keith D; Fuks François; Esteller Manel
Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern.
The Journal of biological chemistry 2004;279(35):37175-84.
2004: Blanco David; Vicent Silvestre; Elizegi Eider; Pino Irene; Fraga Mario F; Esteller Manel; Saffiotti Umberto; Lecanda Fernando; Montuenga Luis M
Altered expression of adhesion molecules and epithelial-mesenchymal transition in silica-induced rat lung carcinogenesis.
Laboratory investigation; a journal of technical methods and pathology 2004;84(8):999-1012.
2004: Pellisé Maria; Castells Antoni; Ginès Angels; Agrelo Rubén; Solé Manel; Castellví-Bel Sergi; Fernández-Esparrach Glòria; Llach Josep; Esteller Manel; Bordas Josep M; Piqué Josep M
Detection of lymph node micrometastases by gene promoter hypermethylation in samples obtained by endosonography- guided fine-needle aspiration biopsy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(13):4444-9.
2004: Lund Gertrud; Andersson Linda; Lauria Massimiliano; Lindholm Marie; Fraga Mario F; Villar-Garea Ana; Ballestar Esteban; Esteller Manel; Zaina Silvio
DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E.
The Journal of biological chemistry 2004;279(28):29147-54.
2004: Fernandez Paloma; Carretero Julian; Medina Pedro P; Jimenez Ana I; Rodriguez-Perales Sandra; Paz Maria F; Cigudosa Juan C; Esteller Manel; Lombardia Luis; Morente Manuel; Sanchez-Verde Lydia; Sotelo Teresa; Sanchez-Cespedes Montserrat
Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations.
Oncogene 2004;23(29):5084-91.
2004: Musulén Eva; Moreno Víctor; Reyes German; Sancho Francisco Javier; Peinado Miguel Angel; Esteller Manel; Herman James G; Combalia Neus; Rey Mercè; Capellá Gabriel
Standardized approach for microsatellite instability detection in gastric carcinomas.
Human pathology 2004;35(3):335-42.
2004: Douglas Donna B; Akiyama Yoshimitsu; Carraway Hetty; Belinsky Steven A; Esteller Manel; Gabrielson Edward; Weitzman Sigmund; Williams Trevor; Herman James G; Baylin Stephen B
Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2alpha expression during progression of breast cancer.
Cancer research 2004;64(5):1611-20.
2004: Cascon A; Ruiz-Llorente S; Fraga M F; Leton R; Telleria D; Sastre J; Diez J Jose; Martinez Diaz-Guerra G; Diaz Perez J A; Benitez J; Esteller M; Robledo M
Genetic and epigenetic profile of sporadic pheochromocytomas.
Journal of medical genetics 2004;41(3):e30.
2004: Rossi Davide; Capello Daniela; Gloghini Annunziata; Franceschetti Silvia; Paulli Marco; Bhatia Kishor; Saglio Giuseppe; Vitolo Umberto; Pileri Stefano A; Esteller Manel; Carbone Antonino; Gaidano Gianluca
Aberrant promoter methylation of multiple genes throughout the clinico-pathologic spectrum of B-cell neoplasia.
Haematologica 2004;89(2):154-64.
2004: Nieto María; Samper Enrique; Fraga Mario F; González de Buitrago Gonzalo; Esteller Manel; Serrano Manuel
The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine.
Oncogene 2004;23(3):735-43.
2004: Esteller Manel; Herman James G
Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer.
Oncogene 2004;23(1):1-8.
2004: Peinado Hector; Ballestar Esteban; Esteller Manel; Cano Amparo
Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex.
Molecular and cellular biology 2004;24(1):306-19.
2003: Ballestar Esteban; Paz Maria F; Valle Laura; Wei Susan; Fraga Mario F; Espada Jesus; Cigudosa Juan Cruz; Huang Tim Hui-Ming; Esteller Manel
Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer.
The EMBO journal 2003;22(23):6335-45.
2003: Akiyama Yoshimitsu; Watkins Neil; Suzuki Hiromu; Jair Kam-Wing; van Engeland Manon; Esteller Manel; Sakai Hidekazu; Ren Chun-Yan; Yuasa Yasuhito; Herman James G; Baylin Stephen B
GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer.
Molecular and cellular biology 2003;23(23):8429-39.
2003: Esteller Manel
Profiling aberrant DNA methylation in hematologic neoplasms: a view from the tip of the iceberg.
Clinical immunology (Orlando, Fla.) 2003;109(1):80-8.
2003: Tarafa Gemma; Prat Esther; Risques Rosa-Ana; González Sara; Camps Jordi; Grau Mónica; Guinó Elisabeth; Moreno Víctor; Esteller Manel; Herman James G; Germà Josep-Ramon; Miró Rosa; Peinado Miguel Angel; Capellá Gabriel
Common genetic evolutionary pathways in familial adenomatous polyposis tumors.
Cancer research 2003;63(18):5731-7.
2003: Paz Maria F; Wei Susan; Cigudosa Juan C; Rodriguez-Perales Sandra; Peinado Miguel A; Huang Tim Hui-Ming; Esteller Manel
Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases.
Human molecular genetics 2003;12(17):2209-19.
2003: Villar-Garea Ana; Fraga Mario F; Espada Jesus; Esteller Manel
Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.
Cancer research 2003;63(16):4984-9.
2003: Palmisano William A; Crume Kevin P; Grimes Marcie J; Winters Sally A; Toyota Minoru; Esteller Manel; Joste Nancy; Baylin Stephen B; Belinsky Steven A
Aberrant promoter methylation of the transcription factor genes PAX5 alpha and beta in human cancers.
Cancer research 2003;63(15):4620-5.
2003: Sarrió David; Moreno-Bueno Gema; Hardisson David; Sánchez-Estévez Carolina; Guo Mingzhou; Herman James G; Gamallo Carlos; Esteller Manel; Palacios José
Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability.
International journal of cancer. Journal international du cancer 2003;106(2):208-15.
2003: Esteller Manel
Relevance of DNA methylation in the management of cancer.
The lancet oncology 2003;4(6):351-8.
2003: Fraga Mario F; Ballestar Esteban; Esteller Manel
Capillary electrophoresis-based method to quantitate DNA-protein interactions.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;789(2):431-5.
2003: Holst Charles R; Nuovo Gerard J; Esteller Manel; Chew Karen; Baylin Stephen B; Herman James G; Tlsty Thea D
Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia.
Cancer research 2003;63(7):1596-601.
2003: Moreno-Bueno Gema; Hardisson David; Sarrió David; Sánchez Carolina; Cassia Raúl; Prat Jaime; Herman James G; Esteller Manel; Matías-Guiu Xavier; Palacios José
Abnormalities of E- and P-cadherin and catenin (beta-, gamma-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia.
The Journal of pathology 2003;199(4):471-8.
2003: Galm Oliver; Yoshikawa Hirohide; Esteller Manel; Osieka Rainhardt; Herman James G
SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma.
Blood 2003;101(7):2784-8.
2003: Hernández-Boluda Juan-Carlos; Cervantes Francisco; Colomer Dolors; Vela Mari-Carmen; Costa Dolors; Paz María-Fe; Esteller Manel; Montserrat Emilio
Genomic p16 abnormalities in the progression of chronic myeloid leukemia into blast crisis: a sequential study in 42 patients.
Experimental hematology 2003;31(3):204-10.
2003: Fraga Mario F; Ballestar Esteban; Montoya Guillermo; Taysavang Panya; Wade Paul A; Esteller Manel
The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties.
Nucleic acids research 2003;31(6):1765-74.
2003: Paz Maria F; Fraga Mario F; Avila Sonia; Guo Mingzhou; Pollan Marina; Herman James G; Esteller Manel
A systematic profile of DNA methylation in human cancer cell lines.
Cancer research 2003;63(5):1114-21.
2003: Villar-Garea Ana; Esteller Manel
DNA demethylating agents and chromatin-remodelling drugs: which, how and why?
Current drug metabolism 2003;4(1):11-31.
2003: Chen Wen Yong; Zeng Xiaobei; Carter Mark G; Morrell Craig N; Chiu Yen Ray-Whay; Esteller Manel; Watkins D Neil; Herman James G; Mankowski Joseph L; Baylin Stephen B
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors.
Nature genetics 2003;33(2):197-202.
2003: Bolós Victoria; Peinado Hector; Pérez-Moreno Mirna A; Fraga Mario F; Esteller Manel; Cano Amparo
The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors.
Journal of cell science 2003;116(Pt 3):499-511.
2003: Esteller Manel
Cancer epigenetics: DNA methylation and chromatin alterations in human cancer.
Advances in experimental medicine and biology 2003;532():39-49.
2002: Fournier Cécile; Goto Yuji; Ballestar Esteban; Delaval Katia; Hever Ann M; Esteller Manel; Feil Robert
Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes.
The EMBO journal 2002;21(23):6560-70.
2002: Tort Frederic; Hernàndez Silvia; Beà Silvia; Martínez Antonio; Esteller Manel; Herman James G; Puig Xavier; Camacho Emma; Sánchez Montse; Nayach Iracema; Lopez-Guillermo Armando; Fernández Pedro L; Colomer Dolors; Hernàndez Luis; Campo Elias
CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas.
Blood 2002;100(13):4602-8.
2002: Lerma Enrique; Esteller Manel; Herman James G; Prat Jaime
Alterations of the p16/Rb/cyclin-D1 pathway in vulvar carcinoma, vulvar intraepithelial neoplasia, and lichen sclerosus.
Human pathology 2002;33(11):1120-5.
2002: Moreno-Bueno Gema; Hardisson David; Sánchez Carolina; Sarrió David; Cassia Raúl; García-Rostán Ginesa; Prat Jaime; Guo Mingzhou; Herman James G; Matías-Guiu Xavier; Esteller Manel; Palacios José
Abnormalities of the APC/beta-catenin pathway in endometrial cancer.
Oncogene 2002;21(52):7981-90.
2002: Esteller Manel; Guo Mingzhou; Moreno Victor; Peinado Miquel Angel; Capella Gabriel; Galm Oliver; Baylin Stephen B; Herman James G
Hypermethylation-associated Inactivation of the Cellular Retinol-Binding-Protein 1 Gene in Human Cancer.
Cancer research 2002;62(20):5902-5.
2002: Fraga Mario F; Esteller Manel
DNA methylation: a profile of methods and applications.
BioTechniques 2002;33(3):632, 634, 636-49.
2002: Esteller Manel; Fraga Mario F; Paz Maria F; Campo Elias; Colomer Dolors; Novo Francisco J; Calasanz Maria J; Galm Oliver; Guo Mingzhou; Benitez Javier; Herman James G
Cancer epigenetics and methylation.
Science (New York, N.Y.) 2002;297(5588):1807-8; discussion 1807-8.
2002: Esteller Manel
CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future.
Oncogene 2002;21(35):5427-40.
2002: Paz Maria F; Avila Sonia; Fraga Mario F; Pollan Marina; Capella Gabriel; Peinado Miquel Angel; Sanchez-Cespedes Montserrat; Herman James G; Esteller Manel
Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors.
Cancer research 2002;62(15):4519-24.
2002: Ballestar Esteban; Esteller Manel
The impact of chromatin in human cancer: linking DNA methylation to gene silencing.
Carcinogenesis 2002;23(7):1103-9.
2002: Sanchez-Cespedes Montserrat; Parrella Paola; Esteller Manel; Nomoto Shuji; Trink Barry; Engles James M; Westra William H; Herman James G; Sidransky David
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.
Cancer research 2002;62(13):3659-62.
2002: Fraga Mario F; Uriol Esther; Borja Diego L; Berdasco María; Esteller Manel; Cañal María Jesús; Rodríguez Roberto
High-performance capillary electrophoretic method for the quantification of 5-methyl 2'-deoxycytidine in genomic DNA: application to plant, animal and human cancer tissues.
Electrophoresis 2002;23(11):1677-81.
2002: Esteller Manel
The coming of age of DNA methylation in medicine in the genomics and postgenomics era.
Clinical immunology (Orlando, Fla.) 2002;103(3 Pt 1):213-6.
2002: Osorio Ana; de la Hoya Miguel; Rodríguez-López Raquel; Martínez-Ramírez Angel; Cazorla Alicia; Granizo Juan José; Esteller Manel; Rivas Carmen; Caldés Trinidad; Benítez Javier
Loss of heterozygosity analysis at the BRCA loci in tumor samples from patients with familial breast cancer.
International journal of cancer. Journal international du cancer 2002;99(2):305-9.
2002: Laiho Päivi; Launonen Virpi; Lahermo Päivi; Esteller Manel; Guo Mingzhou; Herman James G; Mecklin Jukka-Pekka; Järvinen Heikki; Sistonen Pertti; Kim Kyoung-Mee; Shibata Darryl; Houlston Richard S; Aaltonen Lauri A
Low-level microsatellite instability in most colorectal carcinomas.
Cancer research 2002;62(4):1166-70.
2002: Esteller Manel; Gaidano Gianluca; Goodman Steven N; Zagonel Vittorina; Capello Daniela; Botto Barbara; Rossi Davide; Gloghini Annunziata; Vitolo Umberto; Carbone Antonino; Baylin Stephen B; Herman James G
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma.
Journal of the National Cancer Institute 2002;94(1):26-32.
2002: Esteller Manel; Herman James G
Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours.
The Journal of pathology 2002;196(1):1-7.
2001: Esteller M; Fraga M F; Guo M; Garcia-Foncillas J; Hedenfalk I; Godwin A K; Trojan J; Vaurs-Barrière C; Bignon Y J; Ramus S; Benitez J; Caldes T; Akiyama Y; Yuasa Y; Launonen V; Canal M J; Rodriguez R; Capella G; Peinado M A; Borg A; Aaltonen L A; Ponder B A; Baylin S B; Herman J G
DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis.
Human molecular genetics 2001;10(26):3001-7.
2001: Sanchez-Cespedes M; Parrella P; Nomoto S; Cohen D; Xiao Y; Esteller M; Jeronimo C; Jordan R C; Nicol T; Koch W M; Schoenberg M; Mazzarelli P; Fazio V M; Sidransky D
Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors.
Cancer research 2001;61(19):7015-9.
2001: Caballero O L; Cohen D; Liu Q; Esteller M; Bonacum J; White P; Engles J; Yochem R; Herman J G; Westra W H; Lengauer C; Sidransky D; Jen J
Loss of chromosome arms 3p and 9p and inactivation of P16 (INK4a) in normal epithelium of patients with primary lung cancer.
Genes, chromosomes & cancer 2001;32(2):119-25.
2001: Cairns P; Esteller M; Herman J G; Schoenberg M; Jeronimo C; Sanchez-Cespedes M; Chow N H; Grasso M; Wu L; Westra W B; Sidransky D
Molecular detection of prostate cancer in urine by GSTP1 hypermethylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(9):2727-30.
2001: Esteller M; Risques R A; Toyota M; Capella G; Moreno V; Peinado M A; Baylin S B; Herman J G
Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis.
Cancer research 2001;61(12):4689-92.
2001: Esteller M; Corn P G; Baylin S B; Herman J G
A gene hypermethylation profile of human cancer.
Cancer research 2001;61(8):3225-9.
2001: Esteller M; Cordon-Cardo C; Corn P G; Meltzer S J; Pohar K S; Watkins D N; Capella G; Peinado M A; Matias-Guiu X; Prat J; Baylin S B; Herman J G
p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2.
Cancer research 2001;61(7):2816-21.
2001: Baylin S B; Esteller M; Rountree M R; Bachman K E; Schuebel K; Herman J G
Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer.
Human molecular genetics 2001;10(7):687-92.
2001: Esteller M; González S; Risques R A; Marcuello E; Mangues R; Germà J R; Herman J G; Capellà G; Peinado M A
K-ras and p16 aberrations confer poor prognosis in human colorectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(2):299-304.
2000: Esteller M
Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes.
European journal of cancer (Oxford, England : 1990) 2000;36(18):2294-300.
2000: Esteller M; Sparks A; Toyota M; Sanchez-Cespedes M; Capella G; Peinado M A; Gonzalez S; Tarafa G; Sidransky D; Meltzer S J; Baylin S B; Herman J G
Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.
Cancer research 2000;60(16):4366-71.
2000: Esteller M; Toyota M; Sanchez-Cespedes M; Capella G; Peinado M A; Watkins D N; Issa J P; Sidransky D; Baylin S B; Herman J G
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
Cancer research 2000;60(9):2368-71.
2000: Sanchez-Cespedes M; Esteller M; Wu L; Nawroz-Danish H; Yoo G H; Koch W M; Jen J; Herman J G; Sidransky D
Gene promoter hypermethylation in tumors and serum of head and neck cancer patients.
Cancer research 2000;60(4):892-5.
2000: Esteller M; Avizienyte E; Corn P G; Lothe R A; Baylin S B; Aaltonen L A; Herman J G
Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome.
Oncogene 2000;19(1):164-8.
1999: Sanchez-Cespedes M; Esteller M; Hibi K; Cope F O; Westra W H; Piantadosi S; Herman J G; Jen J; Sidransky D
Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2450-4.
1999: Esteller M; Hamilton S R; Burger P C; Baylin S B; Herman J G
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.
Cancer research 1999;59(4):793-7.
1999: Esteller M; Sanchez-Cespedes M; Rosell R; Sidransky D; Baylin S B; Herman J G
Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.
Cancer research 1999;59(1):67-70.
1998: Esteller M; Levine R; Baylin S B; Ellenson L H; Herman J G
MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas.
Oncogene 1998;17(18):2413-7.
1998: Esteller M; Corn P G; Urena J M; Gabrielson E; Baylin S B; Herman J G
Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia.
Cancer research 1998;58(20):4515-8.
1998: Cairns P; Evron E; Okami K; Halachmi N; Esteller M; Herman J G; Bose S; Wang S I; Parsons R; Sidransky D
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers.
Oncogene 1998;16(24):3215-8.
1997: Cairns P; Okami K; Halachmi S; Halachmi N; Esteller M; Herman J G; Jen J; Isaacs W B; Bova G S; Sidransky D
Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.
Cancer research 1997;57(22):4997-5000.

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