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Hans-Pietro Eugster

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Thomas W Spahn; Hans-Pietro Eugster; Adriano Fontana; Wolfram Domschke; Torsten Kucharzik
Role of lymphotoxin in experimental models of infectious diseases: potential benefits and risks of a therapeutic inhibition of the lymphotoxin-beta receptor pathway.
Roksana Rodak; Hisashi Kubota; Hideyuki Ishihara; Hans-Pietro Eugster; Dilek Könü; Hanns Möhler; Yasuhiro Yonekawa; Karl Frei
Induction of reactive oxygen intermediates-dependent programmed cell death in human malignant ex vivo glioma cells and inhibition of the vascular endothelial growth factor production by taurolidine.
Franz Koch; Lennart Ivarsson; Katrin Janke; Patrizia Stoitzner; Bernhard Ryffel; Hans-Pietro Eugster; Nikolaus Romani
Development and maturation of Langerhans cells, spleen and bone marrow dendritic cells in TNF-alpha/lymphotoxin-alpha double-deficient mice.

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2005: Thomas W Spahn; Hans-Pietro Eugster; Adriano Fontana; Wolfram Domschke; Torsten Kucharzik
Role of lymphotoxin in experimental models of infectious diseases: potential benefits and risks of a therapeutic inhibition of the lymphotoxin-beta receptor pathway.
Infection and immunity 2005;73(11):7077-88.
2005: Roksana Rodak; Hisashi Kubota; Hideyuki Ishihara; Hans-Pietro Eugster; Dilek Könü; Hanns Möhler; Yasuhiro Yonekawa; Karl Frei
Induction of reactive oxygen intermediates-dependent programmed cell death in human malignant ex vivo glioma cells and inhibition of the vascular endothelial growth factor production by taurolidine.
Journal of neurosurgery 2005;102(6):1055-68.
2005: Franz Koch; Lennart Ivarsson; Katrin Janke; Patrizia Stoitzner; Bernhard Ryffel; Hans-Pietro Eugster; Nikolaus Romani
Development and maturation of Langerhans cells, spleen and bone marrow dendritic cells in TNF-alpha/lymphotoxin-alpha double-deficient mice.
Immunology letters 2005;96(1):109-20.
2003: Marco Prinz; Gerhard Huber; Andrew J S Macpherson; Frank L Heppner; Markus Glatzel; Hans-Pietro Eugster; Norbert Wagner; Adriano Aguzzi
Oral prion infection requires normal numbers of Peyer's patches but not of enteric lymphocytes.
The American journal of pathology 2003;162(4):1103-11.
2003: Urs Eriksson; Michael O Kurrer; Nicole Schmitz; Stephan Marsch; Adriano Fontana; Hans-Pietro Eugster; Manfred Kopf
Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3.
Circulation 2003;107(2):320-5.
2002: Paul Ameloot; Nozomi Takahashi; Bart Everaerdt; Jeroen Hostens; Hans-Pietro Eugster; Walter Fiers; Peter Brouckaert
Bioavailability of recombinant tumor necrosis factor determines its lethality in mice.
European journal of immunology 2002;32(10):2759-65.
2002: Maria L Olleros; Reto Guler; Nadia Corazza; Dominique Vesin; Hans-Pietro Eugster; Gilles Marchal; Pierre Chavarot; Christoph Mueller; IRENE GARCIA
Transmembrane TNF induces an efficient cell-mediated immunity and resistance to Mycobacterium bovis bacillus Calmette-Guérin infection in the absence of secreted TNF and lymphotoxin-alpha.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3394-401.
2001: Hans-Pietro Eugster; Karl Frei; F Winkler; Uwe Koedel; W Pfister; H Lassmann; Adriano Fontana
Superantigen overcomes resistance of IL-6-deficient mice towards MOG-induced EAE by a TNFR1 controlled pathway.
European journal of immunology 2001;31(8):2302-12.
2001: Vivianne I Otto; Philip F Stahel; Mario Rancan; K Kariya; Esther Shohami; Ido Yatsiv; Hans-Pietro Eugster; Thomas Kossmann; Otmar Trentz; Maria Cristina Morganti-Kossmann
Regulation of chemokines and chemokine receptors after experimental closed head injury.
Neuroreport 2001;12(9):2059-64.
2001: M Bopst; IRENE GARCIA; Reto Guler; Maria L Olleros; T Rülicke; M Müller; S Wyss; Karl Frei; Michel Le Hir; Hans-Pietro Eugster
Differential effects of TNF and LTalpha in the host defense against M. bovis BCG.
European journal of immunology 2001;31(6):1935-43.
2001: Thomas W Spahn; Adriano Fontana; A M C Faria; Anthony J Slavin; Hans-Pietro Eugster; Xingmin Zhang; Pandelakis Koni; Nancy H Ruddle; R A Flavell; Paul D Rennert; Howard L Weiner
Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches.
European journal of immunology 2001;31(4):1278-87.
2001: U Eriksson; Michael O Kurrer; Roland Bingisser; Hans-Pietro Eugster; P Saremaslani; F Follath; Stephan Marsch; U Widmer
Lethal autoimmune myocarditis in interferon-gamma receptor-deficient mice: enhanced disease severity by impaired inducible nitric oxide synthase induction.
Circulation 2001;103(1):18-21.
2000: Lesley Probert; Hans-Pietro Eugster; Katerina Akassoglou; Jan Bauer; K Frei; Hans Lassmann; A Fontana
TNFR1 signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease.
Brain : a journal of neurology 2000;123 ( Pt 10)():2005-19.
2000: Philip F Stahel; K Kariya; Esther Shohami; Scott R Barnum; Hans-Pietro Eugster; Otmar Trentz; Thomas Kossmann; Maria Cristina Morganti-Kossmann
Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-alpha following closed head injury in mice.
Journal of neuroimmunology 2000;109(2):164-72.
2000: Philip F Stahel; Esther Shohami; F M Younis; K Kariya; Vivianne I Otto; Philipp M Lenzlinger; M B Grosjean; Hans-Pietro Eugster; Otmar Trentz; Thomas Kossmann; Maria Cristina Morganti-Kossmann
Experimental closed head injury: analysis of neurological outcome, blood-brain barrier dysfunction, intracranial neutrophil infiltration, and neuronal cell death in mice deficient in genes for pro-inflammatory cytokines.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(2):369-80.
1999: Christoph Mueller; Nadia Corazza; S Trachsel-Løseth; Hans-Pietro Eugster; Myriam Bühler-Jungo; Thomas Brunner; Martin A Imboden
Noncleavable transmembrane mouse tumor necrosis factor-alpha (TNFalpha) mediates effects distinct from those of wild-type TNFalpha in vitro and in vivo.
The Journal of biological chemistry 1999;274(53):38112-8.
1999: Nadia Corazza; S Eichenberger; Hans-Pietro Eugster; Christoph Mueller
Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2(-/-) mice upon transfer of CD4(+)CD45RB(hi) T cells.
The Journal of experimental medicine 1999;190(10):1479-92.
1999: M Müller; R Althaus; D Fröhlich; K Frei; Hans-Pietro Eugster
Reduced antilisterial activity of TNF-deficient bone marrow-derived macrophages is due to impaired superoxide production.
European journal of immunology 1999;29(10):3089-97.
1999: R Bachmann; Hans-Pietro Eugster; K Frei; A Fontana; Hans Lassmann
Impairment of TNF-receptor-1 signaling but not fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice.
The American journal of pathology 1999;154(5):1417-22.
1999: Hans-Pietro Eugster; Karl Frei; R Bachmann; H Bluethmann; H Lassmann; Adriano Fontana
Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1.
European journal of immunology 1999;29(2):626-32.
1998: Bernhard RYFFEL; Hans-Pietro Eugster; C Haas; Michel Le Hir
Failure to induce anti-glomerular basement membrane glomerulonephritis in TNF alpha/beta deficient mice.
International journal of experimental pathology 1998;79(6):453-60.
1998: M Bopst; C Haas; B Car; Hans-Pietro Eugster
The combined inactivation of tumor necrosis factor and interleukin-6 prevents induction of the major acute phase proteins by endotoxin.
European journal of immunology 1998;28(12):4130-7.
1998: Hans-Pietro Eugster; Karl Frei; M Kopf; H Lassmann; Adriano Fontana
IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.
European journal of immunology 1998;28(7):2178-87.
1998: H Etter; R Althaus; Hans-Pietro Eugster; Luis Santamaria-Babi; L Weber; René Moser
IL-4 and IL-13 downregulate rolling adhesion of leukocytes to IL-1 or TNF-alpha-activated endothelial cells by limiting the interval of E-selectin expression.
Cytokine 1998;10(6):395-403.
1998: U C Sahrbacher; F Lechner; Hans-Pietro Eugster; Karl Frei; H Lassmann; Adriano Fontana
Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis.
European journal of immunology 1998;28(4):1332-8.
1998: F Boess; M Bopst; R Althaus; S Polsky; S D Cohen; Hans-Pietro Eugster; UA Boelsterli
Acetaminophen hepatotoxicity in tumor necrosis factor/lymphotoxin-alpha gene knockout mice.
Hepatology (Baltimore, Md.) 1998;27(4):1021-9.
1998: Bernhard RYFFEL; Michel Le Hir; M Müller; Hans-Pietro Eugster
Correction of the TNF-LT alpha-deficient phenotype by bone marrow transplantation.
Developmental immunology 1998;6(3-4):253-60.
1997: Ursula Malipiero; Karl Frei; Katharina-Susanne Spanaus; C Agresti; H Lassmann; Michael Hahne; Jürg Tschopp; Hans-Pietro Eugster; Adriano Fontana
Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas- and Fas ligand-deficient lpr and gld mice.
European journal of immunology 1997;27(12):3151-60.
1997: Philip F Stahel; K Frei; A Fontana; Hans-Pietro Eugster; B H Ault; Scott R Barnum
Evidence for intrathecal synthesis of alternative pathway complement activation proteins in experimental meningitis.
The American journal of pathology 1997;151(4):897-904.
1997: Philip F Stahel; K Frei; Hans-Pietro Eugster; A Fontana; K M Hummel; Rick A Wetsel; Robert S Ames; Scott R Barnum
TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):861-9.
1997: Karl Frei; Hans-Pietro Eugster; M Bopst; C S Constantinescu; Ehud Lavi; Adriano Fontana
Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 1997;185(12):2177-82.
1997: Jean-François Gauchat; E Schlagenhauf; NP Feng; René Moser; M Yamage; Pascale Jeannin; Sami Alouani; Greg Elson; L D Notarangelo; T Wells; Hans-Pietro Eugster; Jean-Yves Bonnefoy
A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor.
European journal of immunology 1997;27(4):971-8.
1997: Bernhard RYFFEL; Franco E Di Padova; MH Schreier; Michel Le Hir; Hans-Pietro Eugster; Valerie QUESNIAUX
Lack of type 2 T cell-independent B cell responses and defect in isotype switching in TNF-lymphotoxin alpha-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2126-33.
1997: S M Lugli; NP Feng; Markus H Heim; M Adam; Bruno Schnyder; H Etter; M Yamage; Hans-Pietro Eugster; RA Lutz; G Zurawski; René Moser
Tumor necrosis factor alpha enhances the expression of the interleukin (IL)-4 receptor alpha-chain on endothelial cells increasing IL-4 or IL-13-induced Stat6 activation.
The Journal of biological chemistry 1997;272(9):5487-94.
1997: Michel Le Hir; Hans-Pietro Eugster
Absence of follicular dendritic cells (FDC) in mutant mice with deficient TNF/lymphotoxin (LT) signaling.
Advances in experimental medicine and biology 1997;417():487-91.
1997: W Rudin; Hans-Pietro Eugster; G Bordmann; J Bonato; M Müller; M Yamage; Bernhard RYFFEL
Resistance to cerebral malaria in tumor necrosis factor-alpha/beta-deficient mice is associated with a reduction of intercellular adhesion molecule-1 up-regulation and T helper type 1 response.
The American journal of pathology 1997;150(1):257-66.
1996: Q Su; Hans-Pietro Eugster; B Ryffel; Francis J Dumont
Cyclosporin A enhances the calcium-dependent induction of AP-1 complex and c-fos mRNA in a T cell lymphoma.
Biochemical and biophysical research communications 1996;229(1):249-56.
1996: Michel Le Hir; H Bluethmann; M H Kosco-Vilbois; M Müller; F di Padova; M Moore; Bernhard RYFFEL; Hans-Pietro Eugster
Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling.
The Journal of experimental medicine 1996;183(5):2367-72.
1996: M Müller; Hans-Pietro Eugster; Michel Le Hir; A Shakhov; F Di Padova; C Maurer; Valerie QUESNIAUX; Bernhard RYFFEL
Correction or transfer of immunodeficiency due to TNF-LT alpha deletion by bone marrow transplantation.
Molecular medicine (Cambridge, Mass.) 1996;2(2):247-55.
1996: Hans-Pietro Eugster; M Muller; U Karrer; Bruce D Car; Bruno Schnyder; V M Eng; G Woerly; Michel Le Hir; F di Padova; M Aguet; Rolf M Zinkernagel; H Bluethmann; Bernhard RYFFEL
Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice.
International immunology 1996;8(1):23-36.
1995: Q Su; M Zhao; E Weber; Hans-Pietro Eugster; Bernhard RYFFEL
Distribution and activity of calcineurin in rat tissues. Evidence for post-transcriptional regulation of testis-specific calcineurin B.
European journal of biochemistry / FEBS 1995;230(2):469-74.
1995: Didier Heumann; D Le Roy; G Zanetti; Hans-Pietro Eugster; B Ryffel; M Hahne; J Tschopp; Michel-Pierre Glauser
Contribution of TNF/TNF receptor and of Fas ligand to toxicity in murine models of endotoxemia and bacterial peritonitis.
Journal of inflammation 1995;47(4):173-9.
1995: Michel Le Hir; H Bluethmann; M H Kosco-Vilbois; M Müller; F di Padova; M Moore; Bernhard RYFFEL; Hans-Pietro Eugster
Tumor necrosis factor receptor-1 signaling is required for differentiation of follicular dendritic cells, germinal center formation, and full antibody responses.
Journal of inflammation 1995;47(1-2):76-80.
1994: C Sengstag; Hans-Pietro Eugster; Friedrich E Würgler
High promutagen activating capacity of yeast microsomes containing human cytochrome P-450 1A and human NADPH-cytochrome P-450 reductase.
Carcinogenesis 1994;15(5):837-43.
1993: H L Tai; J H McReynolds; J A Goldstein; Hans-Pietro Eugster; C Sengstag; W L Alworth; James R Olson
Cytochrome P4501A1 mediates the metabolism of 2,3,7,8-tetrachlorodibenzofuran in the rat and human.
Toxicology and applied pharmacology 1993;123(1):34-42.
1993: Hans-Pietro Eugster; C Sengstag
Saccharomyces cerevisiae: an alternative source for human microsomal liver enzymes and its use in drug interaction studies.
Toxicology 1993;82(1-3):61-73.
1993: Bernhard RYFFEL; G Woerly; M Murray; Hans-Pietro Eugster; Bruce D Car
Binding of active cyclosporins to cyclophilin A and B, complex formation with calcineurin A.
Biochemical and biophysical research communications 1993;194(3):1074-83.
1993: Hans-Pietro Eugster; M Probst; Friedrich E Würgler; C Sengstag
Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(1):43-9.
1992: Hans-Pietro Eugster; S Bärtsch; Friedrich E Würgler; C Sengstag
Functional co-expression of human oxidoreductase and cytochrome P450 1A1 in Saccharomyces cerevisiae results in increased EROD activity.
Biochemical and biophysical research communications 1992;185(2):641-7.
1991: Hans-Pietro Eugster; C Sengstag; A Hinnen; U A Meyer; Friedrich E Würgler
Heterologous expression of human microsomal epoxide hydrolase in Saccharomyces cerevisiae. Study of the valpromide-carbamazepine epoxide interaction.
Biochemical pharmacology 1991;42(7):1367-72.
1990: Hans-Pietro Eugster; C Sengstag; U A Meyer; A Hinnen; Friedrich E Würgler
Constitutive and inducible expression of human cytochrome P450IA1 in yeast Saccharomyces cerevisiae: an alternative enzyme source for in vitro studies.
Biochemical and biophysical research communications 1990;172(2):737-44.