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Christopher Evans

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Rheumatoid Arthritis

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Nam Vo; Lloydine Jacobs; James Kang; Luigi Aurelio Nasto; Laura J Niedernhofer; Paul D Robbins; Christopher H Evans
An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints.
Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
Arthritis gene therapy and its tortuous path into the clinic.
Fangjun Liu; Carmencita Pilapil; Ryan M Porter; James Wells; Vaida Glatt; Christopher H Evans
Evaluation of BMP-2 gene-activated muscle grafts for cranial defect repair.

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2013: Nam Vo; Lloydine Jacobs; James Kang; Luigi Aurelio Nasto; Laura J Niedernhofer; Paul D Robbins; Christopher H Evans
An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2013;31(6):831-7.
2013: Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
Arthritis gene therapy and its tortuous path into the clinic.
Translational research : the journal of laboratory and clinical medicine 2013;161(4):205-16.
2012: Fangjun Liu; Carmencita Pilapil; Ryan M Porter; James Wells; Vaida Glatt; Christopher H Evans
Evaluation of BMP-2 gene-activated muscle grafts for cranial defect repair.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2012;30(7):1095-102.
2012: Martin Majewski; Ryan M Porter; Rudolf Flückiger; Oliver Betz; Volker M Betz; Harald Clahsen; Christopher H Evans
Improvement of tendon repair using muscle grafts transduced with TGF-β1 cDNA.
European cells & materials 2012;23():94-101; discussion 101-2.
2011: Yihong C S Lu; Christopher H Evans; Alan J Grodzinsky
Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines.
Arthritis research & therapy 2011;13(5):R142.
2011: Alan Ivkovic; Inga Marijanovic; Damir Hudetz; Ryan M Porter; Marko Pecina; Christopher H Evans
Regenerative medicine and tissue engineering in orthopaedic surgery.
Frontiers in bioscience (Elite edition) 2011;3():923-44.
2010: Meike Haddad-Weber; Patrick Prager; Manuela Kunz; Lothar Seefried; Franz Jakob; Martha M Murray; Christopher H Evans; Ulrich Nöth; Andre Steinert
BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells.
Cytotherapy 2010;12(4):505-13.
2009: Jesse D Kay; Elvire Gouze; Thomas J Oligino; Jean-Noel Gouze; Rachael S Watson; Padraic P Levings; Marsha L Bush; Anthony Dacanay; David M Nickerson; Paul D Robbins; Christopher H Evans; Steven C Ghivizzani
Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus.
The journal of gene medicine 2009;11(7):605-14.
2009: Francois N K Kwong; Judith A Hoyland; Anthony J Freemont; Christopher H Evans
Altered relative expression of BMPs and BMP inhibitors in cartilaginous areas of human fractures progressing towards nonunion.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2009;27(6):752-7.
2009: Andre Steinert; Glyn D Palmer; Carmencita Pilapil; Ulrich Nöth; Christopher H Evans; Steven C Ghivizzani
Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer.
Tissue engineering. Part A 2009;15(5):1127-39.
2009: Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
Orthopedic gene therapy in 2008.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(2):231-44.
2009: Francois N K Kwong; Judith A Hoyland; Christopher H Evans; Anthony J Freemont
Regional and cellular localisation of BMPs and their inhibitors' expression in human fractures.
International orthopaedics 2009;33(1):281-8.
2009: Peter Wehling; Julio A Reinecke; Axel W A Baltzer; M Granrath; KP Schulitz; Carl Schultz; Rüdiger Krauspe; Theresa W Whiteside; Elaine Elder; Steven C Ghivizzani; Paul D Robbins; Christopher H Evans
Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis.
Human gene therapy 2009;20(2):97-101.
2009: Christopher H Evans; F-J Liu; Vaida Glatt; J A Hoyland; C Kirker-Head; A Walsh; Oliver Betz; J W Wells; Volker M Betz; R M Porter; F A Saad; Louis C Gerstenfeld; Thomas A Einhorn; Mitchel B Harris; Mark S Vrahas
Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage.
European cells & materials 2009;18():96-111.
2009: Andre Steinert; Benedikt Proffen; Manuela Kunz; Christian Hendrich; Steven C Ghivizzani; Ulrich Nöth; Axel Rethwilm; Jochen Eulert; Christopher H Evans
Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer.
Arthritis research & therapy 2009;11(5):R148.
2009: Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
Gene therapy of the rheumatic diseases: 1998 to 2008.
Arthritis research & therapy 2009;11(1):209.
2008: Steven C Ghivizzani; Elvire Gouze; Jean-Noel Gouze; Jesse D Kay; Marsha L Bush; Rachael S Watson; Padraic P Levings; David M Nickerson; Patrick T Colahan; Paul D Robbins; Christopher H Evans
Perspectives on the use of gene therapy for chronic joint diseases.
Current gene therapy 2008;8(4):273-86.
2008: Glyn D Palmer; Martin Stoddart; Elvire Gouze; Jean-Noel Gouze; Steven C Ghivizzani; R M Porter; Christopher H Evans
A simple, lanthanide-based method to enhance the transduction efficiency of adenovirus vectors.
Gene therapy 2008;15(5):357-63.
2008: Andre Steinert; Meike Weber; Manuela Kunz; Glyn D Palmer; Ulrich Nöth; Christopher H Evans; Martha M Murray
In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament.
Biomaterials 2008;29(7):904-16.
2008: Francois N K Kwong; Stephen M Richardson; Christopher H Evans
Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells.
Arthritis research & therapy 2008;10(3):R65.
2008: Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
Arthritis gene therapy's first death.
Arthritis research & therapy 2008;10(3):110.
2008: Volker M Betz; Oliver Betz; Mitchel B Harris; Mark S Vrahas; Christopher H Evans
Bone tissue engineering and repair by gene therapy.
Frontiers in bioscience : a journal and virtual library 2008;13():833-41.
2007: Volker M Betz; Oliver Betz; Vaida Glatt; Louis C Gerstenfeld; Thomas A Einhorn; Mary L Bouxsein; Mark S Vrahas; Christopher H Evans
Healing of segmental bone defects by direct percutaneous gene delivery: effect of vector dose.
Human gene therapy 2007;18(10):907-15.
2007: Andre Steinert; Glyn D Palmer; Ramille Capito; Jochen G Hofstaetter; Carmencita Pilapil; Steven C Ghivizzani; Myron Spector; Christopher H Evans
Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta 1 complementary deoxyribonucleic acid.
Tissue engineering 2007;13(9):2227-37.
2007: Christopher H Evans; Glyn D Palmer; Arnulf Pascher; Ryan Porter; Francois N Kwong; Elvire Gouze; Jean-Noel Gouze; Fangjun Liu; Andre Steinert; Oliver Betz; Volker Betz; Mark S Vrahas; Steven C Ghivizzani
Facilitated endogenous repair: making tissue engineering simple, practical, and economical.
Tissue engineering 2007;13(8):1987-93.
2007: Oliver Betz; Volker M Betz; Ara Nazarian; M Egermann; Louis C Gerstenfeld; Thomas A Einhorn; Mark S Vrahas; Mary L Bouxsein; Christopher H Evans
Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defects.
Gene therapy 2007;14(13):1039-44.
2007: Elvire Gouze; Jean-Noel Gouze; Glyn D Palmer; Carmencita Pilapil; Christopher H Evans; Steven C Ghivizzani
Transgene persistence and cell turnover in the diarthrodial joint: implications for gene therapy of chronic joint diseases.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(6):1114-20.
2007: Christopher H Evans
John Hunter and the origins of modern orthopaedic research.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2007;25(4):556-60.
2007: Jean-Noel Gouze; Christopher H Evans; Steven C Ghivizzani; Elvire Gouze
[Gene therapy for osteoarticular disorders].
Médecine sciences : M/S 2007;23(3):303-9.
2007: Andre Steinert; Steven C Ghivizzani; Axel Rethwilm; Rocky S Tuan; Christopher H Evans; Ulrich Nöth
Major biological obstacles for persistent cell-based regeneration of articular cartilage.
Arthritis research & therapy 2007;9(3):213.
2006: Lorenz Meinel; Sandra Hofmann; Oliver Betz; Robert Fajardo; Hans P Merkle; Robert Langer; Christopher H Evans; Gordana Vunjak-Novakovic; David L Kaplan
Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials: comparison of adenovirus mediated gene transfer and protein delivery of BMP-2.
Biomaterials 2006;27(28):4993-5002.
2006: Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
Will arthritis gene therapy become a clinical reality?
Nature clinical practice. Rheumatology 2006;2(7):344-5.
2006: Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
Gene therapy for arthritis: what next?
Arthritis and rheumatism 2006;54(6):1714-29.
2006: Christopher H Evans; Elvire Gouze; Jean-Noel Gouze; Paul D Robbins; Steven C Ghivizzani
Gene therapeutic approaches-transfer in vivo.
Advanced drug delivery reviews 2006;58(2):243-58.
2006: Oliver Betz; Volker M Betz; Ara Nazarian; Carmencita G Pilapil; Mark S Vrahas; Mary L Bouxsein; Louis C Gerstenfeld; Thomas A Einhorn; Christopher H Evans
Direct percutaneous gene delivery to enhance healing of segmental bone defects.
The Journal of bone and joint surgery. American volume 2006;88(2):355-65.
2005: Christopher H Evans; Randy N Rosier
Molecular biology in orthopaedics: the advent of molecular orthopaedics.
The Journal of bone and joint surgery. American volume 2005;87(11):2550-64.
2005: Glyn D Palmer; Andre Steinert; Arnulf Pascher; Elvire Gouze; Jean-Noel Gouze; Oliver Betz; Brian Johnstone; Christopher H Evans; Steven C Ghivizzani
Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(2):219-28.
2005: Christopher H Evans; Steven C Ghivizzani; James H Herndon; Paul D Robbins
Gene therapy for the treatment of musculoskeletal diseases.
The Journal of the American Academy of Orthopaedic Surgeons 2005;13(4):230-42.
2005: Christopher H Evans; Paul D Robbins; Steven C Ghivizzani; Mary Chester Wasko; Matthew M Tomaino; Richard Kang; Thomas A Muzzonigro; Molly Vogt; Elaine Elder; Theresa L Whiteside; simon simon watkins; James H Herndon
Gene transfer to human joints: progress toward a gene therapy of arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(24):8698-703.
2005: Christopher H Evans
Novel biological approaches to the intra-articular treatment of osteoarthritis.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2005;19(6):355-62.
2005: Christopher H Evans; Steven C Ghivizzani; Elvire Gouze; John J Rediske; Edward M Schwarz; Paul D Robbins
The 3rd International Meeting on Gene Therapy in Rheumatology and Orthopaedics.
Arthritis research & therapy 2005;7(6):273-8.
2005: Christopher H Evans
Gene therapy: what have we accomplished and where do we go from here?
The Journal of rheumatology. Supplement 2005;72():17-20.
2004: Christopher H Evans; Steven C Ghivizzani; Paul D Robbins
The 2003 Nicolas Andry Award. Orthopaedic gene therapy.
Clinical orthopaedics and related research 2004;(429):316-29.
2004: Sudha Agarwal; James Deschner; Ping Long; Anupam Verma; Cynthia Hofman; Christopher H Evans; Nicholas Piesco
Role of NF-kappaB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals.
Arthritis and rheumatism 2004;50(11):3541-8.
2004: christian lattermann; Boris A Zelle; Janey D Whalen; Axel W A Baltzer; Paul D Robbins; Christopher Niyibizi; Christopher H Evans; Freddie H Fu
Gene transfer to the tendon-bone insertion site.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 2004;12(5):510-5.
2004: Arnulf Pascher; Andre Steinert; Glyn D Palmer; Oliver Betz; Jean-Noel Gouze; Elvire Gouze; Carmencita Pilapil; Steven C Ghivizzani; Christopher H Evans; Martha M Murray
Enhanced repair of the anterior cruciate ligament by in situ gene transfer: evaluation in an in vitro model.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(2):327-36.
2004: christian lattermann; Axel W A Baltzer; Boris A Zelle; Janey D Whalen; Christopher Niyibizi; Paul D Robbins; Christopher H Evans; Gary S Gruen
Feasibility of percutaneous gene transfer to an atrophic nonunion in a rabbit.
Clinical orthopaedics and related research 2004;(425):237-43.
2004: Christopher H Evans
On the TRAIL of an arthritis cure.
Gene therapy 2004;11(9):735-6.
2004: Jean-Noel Gouze; Elvire Gouze; Glyn D Palmer; H Kaneto; Steven C Ghivizzani; Alan J Grodzinsky; Christopher H Evans
Adenovirus-mediated gene transfer of glutamine: fructose-6-phosphate amidotransferase antagonizes the effects of interleukin-1beta on rat chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(3):217-24.
2004: Christopher H Evans; Jean-Noel Gouze; Elvire Gouze; Paul D Robbins; Steven C Ghivizzani
Osteoarthritis gene therapy.
Gene therapy 2004;11(4):379-89.
2004: Christopher H Evans
Gene therapies for osteoarthritis.
Current rheumatology reports 2004;6(1):31-40.
2004: Jean-Noel Gouze; Martin Stoddart; Elvire Gouze; Glyn D Palmer; Steven C Ghivizzani; Alan J Grodzinsky; Christopher H Evans
In vitro gene transfer to chondrocytes and synovial fibroblasts by adenoviral vectors.
Methods in molecular medicine 2004;100():147-64.
2004: Arnulf Pascher; Glyn D Palmer; Andre Steinert; Thomas J Oligino; Elvire Gouze; Jean-Noel Gouze; Oliver Betz; Myron Spector; Paul D Robbins; Christopher H Evans; Steven C Ghivizzani
Gene delivery to cartilage defects using coagulated bone marrow aspirate.
Gene therapy 2004;11(2):133-41.
2003: Q Yao; S Wang; Andrea Gambotto; Joseph C Glorioso; Christopher H Evans; Paul D Robbins; Steven C Ghivizzani; Thomas J Oligino
Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium.
Gene therapy 2003;10(12):1055-60.
2003: Paul D Robbins; Christopher H Evans; Y Chernajovsky
Gene therapy for arthritis.
Gene therapy 2003;10(10):902-11.
2003: Elvire Gouze; Robert Pawliuk; Jean-Noel Gouze; Carmencita Pilapil; Christina Fleet; Glyn D Palmer; Christopher H Evans; Philippe Leboulch; Steven C Ghivizzani
Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(4):460-6.
2003: Jean-Noel Gouze; Elvire Gouze; Glyn D Palmer; Victor S Liew; Arnulf Pascher; Oliver Betz; Thomas S Thornhill; Christopher H Evans; Alan J Grodzinsky; Steven C Ghivizzani
A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer.
Arthritis research & therapy 2003;5(5):R301-9.
2003: Zhibao Mi; Steven C Ghivizzani; Eric R Lechman; Joseph C Glorioso; Christopher H Evans; Paul D Robbins
Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees.
Arthritis research & therapy 2003;5(3):R132-9.
2003: Glyn D Palmer; Elvire Gouze; Jean-Noel Gouze; Oliver Betz; Christopher H Evans; Steven C Ghivizzani
Gene transfer to articular chondrocytes with recombinant adenovirus.
Methods in molecular biology (Clifton, N.J.) 2003;215():235-46.
2002: Elvire Gouze; Robert Pawliuk; Carmencita Pilapil; Jean-Noel Gouze; Christina Fleet; Glyn D Palmer; Christopher H Evans; Philippe Leboulch; Steven C Ghivizzani
In vivo gene delivery to synovium by lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(4):397-404.
2002: Glyn Palmer; Arnulf Pascher; Elvire Gouze; Jean-Noel Gouze; Oliver Betz; Myron Spector; Paul D Robbins; Christopher H Evans; Steven C Ghivizzani
Development of gene-based therapies for cartilage repair.
Critical reviews in eukaryotic gene expression 2002;12(4):259-73.
2001: Jean-Noel Gouze; Steven C Ghivizzani; Elvire Gouze; Glyn D Palmer; Oliver Betz; Paul D Robbins; Christopher H Evans; James H Herndon
Gene therapy for rheumatoid arthritis.
Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand 2001;6(2):211-9.
2001: Axel W A Baltzer; Janey D Whalen; Paul H Wooley; C Latterman; L M Truchan; Paul D Robbins; Christopher H Evans
Gene therapy for osteoporosis: evaluation in a murine ovariectomy model.
Gene therapy 2001;8(23):1770-6.
2001: J D Whalen; Angus W Thomson; Lina Lu; Paul D Robbins; Christopher H Evans
Viral IL-10 gene transfer inhibits DTH responses to soluble antigens: evidence for involvement of genetically modified dendritic cells and macrophages.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(6):543-50.
2001: Elvire Gouze; Steven C Ghivizzani; Glyn D Palmer; Jean-Noel Gouze; Paul D Robbins; Christopher H Evans
Gene therapy for rheumatoid arthritis.
Expert opinion on biological therapy 2001;1(6):971-8.
2001: Q Yao; Shaomeng Wang; Joseph C Glorioso; Christopher H Evans; Paul D Robbins; Steven C Ghivizzani; Thomas J Oligino
Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(6):901-10.
2001: Seon Hee Kim; S Kim; Christopher H Evans; Steven C Ghivizzani; Thomas J Oligino; Paul D Robbins
Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3499-505.
2001: Elvire Gouze; Steven C Ghivizzani; Paul D Robbins; Christopher H Evans
Gene therapy for rheumatoid arthritis.
Current rheumatology reports 2001;3(1):79-85.
2001: M A Del Vecchio; Helga I Georgescu; JE McCormack; Paul D Robbins; Christopher H Evans
Approaches to enhancing the retroviral transduction of human synoviocytes.
Arthritis research 2001;3(4):259-63.
2001: Christopher H Evans; Steven C Ghivizzani; T A Oligino; Paul D Robbins
Future of adenoviruses in the gene therapy of arthritis.
Arthritis research 2001;3(3):142-6.
2000: Zhibao Mi; Steven C Ghivizzani; Eric R Lechman; D Jaffurs; Joseph C Glorioso; Christopher H Evans; Paul D Robbins
Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints.
Arthritis and rheumatism 2000;43(11):2563-70.
2000: S H Moon; Lars G Gilbertson; K Nishida; M Knaub; Thomas S Muzzonigro; Paul D Robbins; Christopher H Evans; James D Kang
Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer: implications for the clinical management of intervertebral disc disorders.
Spine 2000;25(20):2573-9.
2000: Robert Gassner; Michael J Buckley; Rebecca K Studer; Christopher H Evans; S Agarwal
Interaction of strain and interleukin-1 in articular cartilage: effects on proteoglycan synthesis in chondrocytes.
International journal of oral and maxillofacial surgery 2000;29(5):389-94.
2000: Steven C Ghivizzani; Christopher H Evans
Gene therapy for rheumatoid arthritis.
Clinical orthopaedics and related research 2000;(379 Suppl):S308-10.
2000: Christopher H Evans; Steven C Ghivizzani; James H Herndon; Mary Chester Wasko; Julio A Reinecke; Peter Wehling; Paul D Robbins
Clinical trials in the gene therapy of arthritis.
Clinical orthopaedics and related research 2000;(379 Suppl):S300-7.
2000: Steven C Ghivizzani; Thomas J Oligino; J C Glorioso; Paul D Robbins; Christopher H Evans
Gene therapy approaches for treating rheumatoid arthritis.
Clinical orthopaedics and related research 2000;(379 Suppl):S288-99.
2000: K Nishida; Lars G Gilbertson; Paul D Robbins; Christopher H Evans; James D Kang
Potential applications of gene therapy to the treatment of intervertebral disc disorders.
Clinical orthopaedics and related research 2000;(379 Suppl):S234-41.
2000: Christopher H Evans; Steven C Ghivizzani; P Smith; FD Shuler; Z Mi; Paul D Robbins
Using gene therapy to protect and restore cartilage.
Clinical orthopaedics and related research 2000;(379 Suppl):S214-9.
2000: Axel W A Baltzer; christian lattermann; Janey D Whalen; Steven C Ghivizzani; Paul H Wooley; Rüdiger Krauspe; Paul D Robbins; Christopher H Evans
Potential role of direct adenoviral gene transfer in enhancing fracture repair.
Clinical orthopaedics and related research 2000;(379 Suppl):S120-5.
2000: Rebecca K Studer; Eric A Levicoff; Helga I Georgescu; L Miller; D Jaffurs; Christopher H Evans
Nitric oxide inhibits chondrocyte response to IGF-I: inhibition of IGF-IRbeta tyrosine phosphorylation.
American journal of physiology. Cell physiology 2000;279(4):C961-9.
2000: FD Shuler; Helga I Georgescu; Christopher Niyibizi; Rebecca K Studer; Z Mi; B Johnstone; R D Robbins; Christopher H Evans
Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta1 gene into articular chondrocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(4):585-92.
2000: H Goto; FD Shuler; Christopher Niyibizi; Freddie H Fu; Paul D Robbins; Christopher H Evans
Gene therapy for meniscal injury: enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFbeta(1)gene.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(4):266-71.
2000: Z Xu; Michael J Buckley; Christopher H Evans; S Agarwal
Cyclic tensile strain acts as an antagonist of IL-1 beta actions in chondrocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):453-60.
2000: R Kang; Steven C Ghivizzani; Thomas S Muzzonigro; James H Herndon; Paul D Robbins; Christopher H Evans
The Marshall R. Urist Young Investigator Award. Orthopaedic applications of gene therapy. From concept to clinic.
Clinical orthopaedics and related research 2000;(375):324-37.
2000: K Nishida; Lars G Gilbertson; Christopher H Evans; James D Kang
Spine update: potential applications of gene therapy to the treatment of spinal disorders.
Spine 2000;25(10):1308-14.
2000: Axel W A Baltzer; christian lattermann; Janey D Whalen; Paul H Wooley; K Weiss; Michele J Grimm; Steven C Ghivizzani; Paul D Robbins; Christopher H Evans
Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene.
Gene therapy 2000;7(9):734-9.
2000: P Smith; FD Shuler; Helga I Georgescu; Steven C Ghivizzani; B Johnstone; Christopher Niyibizi; Paul D Robbins; Christopher H Evans
Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1.
Arthritis and rheumatism 2000;43(5):1156-64.
2000: V. Franklin Sechriest; Y J Miao; Christopher Niyibizi; A Westerhausen-Larson; Howard W T Matthew; Christopher H Evans; F H Fu; Jun-Kyo Francis Suh
GAG-augmented polysaccharide hydrogel: a novel biocompatible and biodegradable material to support chondrogenesis.
Journal of biomedical materials research 2000;49(4):534-41.
2000: HD Möller; Christopher H Evans; N Maffulli
[Current aspects of tendon healing].
Der Orthopäde 2000;29(3):182-7.
2000: M Cao; Maja Stefanovic-Racic; Helga I Georgescu; Freddie H Fu; Christopher H Evans
Does nitric oxide help explain the differential healing capacity of the anterior cruciate, posterior cruciate, and medial collateral ligaments?
The American journal of sports medicine 2000;28(2):176-82.
2000: HD Möller; Freddie H Fu; Christopher Niyibizi; Rebecca K Studer; H J Georgescu; Paul D Robbins; Christopher H Evans
[TGF-beta-1 gene transfer in joint cartilage cells. Stimulating effect in extracellular matrix synthesis].
Der Orthopäde 2000;29(2):75-9.
2000: S H Kim; Christopher H Evans; S Kim; Thomas J Oligino; Steven C Ghivizzani; Paul D Robbins
Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4.
Arthritis research 2000;2(4):293-302.
1999: K R Weiss; Helga I Georgescu; Susanne M Gollin; Richard Kang; Christopher H Evans
Trisomy 7 in synovial fibroblasts obtained from arthritic joints.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1999;48 Suppl 2():S132-3.
1999: K Nishida; James D Kang; Lars G Gilbertson; S H Moon; J K Suh; Molly T Vogt; Paul D Robbins; Christopher H Evans
Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene.
Spine 1999;24(23):2419-25.
1999: Axel W A Baltzer; Janey D Whalen; M Stefanovic-Racic; B Ziran; Paul D Robbins; Christopher H Evans
Adenoviral transduction of human osteoblastic cell cultures: a new perspective for gene therapy of bone diseases.
Acta orthopaedica Scandinavica 1999;70(5):419-24.
1999: Christopher H Evans; Paul D Robbins
Genetically augmented tissue engineering of the musculoskeletal system.
Clinical orthopaedics and related research 1999;(367 Suppl):S410-8.
1999: Eric R Lechman; D Jaffurs; Steven C Ghivizzani; Andrea Gambotto; Imre Kovesdi; Zhibao Mi; Christopher H Evans; Paul D Robbins
Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):2202-8.
1999: Robert Gassner; Michael J Buckley; H Georgescu; Rebecca K Studer; M Stefanovich-Racic; Nicholas Piesco; Christopher H Evans; S Agarwal
Cyclic tensile stress exerts antiinflammatory actions on chondrocytes by inhibiting inducible nitric oxide synthase.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):2187-92.
1999: Christopher H Evans
Cytokines and the role they play in the healing of ligaments and tendons.
Sports medicine (Auckland, N.Z.) 1999;28(2):71-6.
1999: H Goto; FD Shuler; C Lamsam; H D Moller; Christopher Niyibizi; Freddie H Fu; Paul D Robbins; Christopher H Evans
Transfer of lacZ marker gene to the meniscus.
The Journal of bone and joint surgery. American volume 1999;81(7):918-25.
1999: Rebecca K Studer; D Jaffurs; Maja Stefanovic-Racic; Paul D Robbins; Christopher H Evans
Nitric oxide in osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(4):377-9.
1999: Douglas S Musgrave; Patrick P Bosch; Steven C Ghivizzani; Paul D Robbins; Christopher H Evans; Johnny Huard
Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone.
Bone 1999;24(6):541-7.
1999: Christopher H Evans; Paul D Robbins
Potential treatment of osteoarthritis by gene therapy.
Rheumatic diseases clinics of North America 1999;25(2):333-44.
1999: Steven C Ghivizzani; Thomas S Muzzonigro; R Kang; Christopher H Evans; Paul D Robbins
Clinical gene therapy for arthritis.
Drugs of today (Barcelona, Spain : 1998) 1999;35(4-5):389-96.
1999: Paul D Robbins; Christopher H Evans
Arthritis gene therapy.
Drugs of today (Barcelona, Spain : 1998) 1999;35(4-5):353-60.
1999: Axel W A Baltzer; Janey D Whalen; T Muzzonegro; H I Georgescu; Paul D Robbins; Christopher H Evans
[In vitro transduction of human osteoblast cell populations with retroviral vectors].
Zeitschrift für Rheumatologie 1999;58(2):88-94.
1999: Christopher H Evans; JJ Rediske; S B Abramson; Paul D Robbins
Joint efforts: tackling arthritis using gene therapy. First International Meeting on the Gene Therapy of Arthritis and Related Disorders. Bethesda, MD, USA, 2-3 December 1998.
Molecular medicine today 1999;5(4):148-51.
1999: J D Whalen; E L Lechman; Casey A Carlos; K Weiss; Imre Kovesdi; Joseph C Glorioso; Paul D Robbins; Christopher H Evans
Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3625-32.
1999: M Oyama; A Tatlock; S Fukuta; KW Kavalkovich; K Nishimura; B Johnstone; Paul D Robbins; Christopher H Evans; Christopher Niyibizi
Retrovirally transduced bone marrow stromal cells isolated from a mouse model of human osteogenesis imperfecta (oim) persist in bone and retain the ability to form cartilage and bone after extended passaging.
Gene therapy 1999;6(3):321-9.
1999: Rebecca K Studer; Helga I Georgescu; LA Miller; Christopher H Evans
Inhibition of transforming growth factor beta production by nitric oxide-treated chondrocytes: implications for matrix synthesis.
Arthritis and rheumatism 1999;42(2):248-57.
1999: Christopher H Evans; Steven C Ghivizzani; Eric R Lechman; Zhibao Mi; D Jaffurs; Paul D Robbins
Lessons learned from gene transfer approaches.
Arthritis research 1999;1(1):21-4.
1999: Axel W A Baltzer; christian lattermann; Janey D Whalen; S Braunstein; Paul D Robbins; Christopher H Evans
A gene therapy approach to accelerating bone healing. Evaluation of gene expression in a New Zealand white rabbit model.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 1999;7(3):197-202.
1999: Jun-Kyo Francis Suh; Goo Hyun Baek; A Arøen; C M Malin; Christopher Niyibizi; Christopher H Evans; A Westerhausen-Larson
Intermittent sub-ambient interstitial hydrostatic pressure as a potential mechanical stimulator for chondrocyte metabolism.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(1):71-80.
1999: HD Möller; Christopher H Evans
[Gene transfer in the treatment of arthritis].
Der Orthopäde 1999;28(1):76-81.
1999: KA Hildebrand; M Deie; Christina R Allen; DW Smith; Helga I Georgescu; Christopher H Evans; Paul D Robbins; Savio L-Y. Woo
Early expression of marker genes in the rabbit medial collateral and anterior cruciate ligaments: the use of different viral vectors and the effects of injury.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1999;17(1):37-42.
1999: Thomas S Muzzonigro; Steven C Ghivizzani; Paul D Robbins; Christopher H Evans
The role of gene therapy. Fact or fiction?
Clinics in sports medicine 1999;18(1):223-39, vii-viii.
1999: Christopher H Evans; Steven C Ghivizzani; Richard Kang; Thomas S Muzzonigro; Mary Chester Wasko; James H Herndon; Paul D Robbins
Gene therapy for rheumatic diseases.
Arthritis and rheumatism 1999;42(1):1-16.
1998: K Nishida; James D Kang; J K Suh; Paul D Robbins; Christopher H Evans; Lars G Gilbertson
Adenovirus-mediated gene transfer to nucleus pulposus cells. Implications for the treatment of intervertebral disc degeneration.
Spine 1998;23(22):2437-42; discussion 2443.
1998: Christopher Niyibizi; Axel W A Baltzer; christian lattermann; M Oyama; Janey D Whalen; Paul D Robbins; Christopher H Evans
Potential role for gene therapy in the enhancement of fracture healing.
Clinical orthopaedics and related research 1998;(355 Suppl):S148-53.
1998: Steven C Ghivizzani; Eric R Lechman; Richard Kang; C Tio; Jay K Kolls; Christopher H Evans; Paul D Robbins
Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4613-8.
1998: C Lamsam; Freddie H Fu; Paul D Robbins; Christopher H Evans
Gene therapy in sports medicine.
Sports medicine (Auckland, N.Z.) 1998;25(2):73-7.
1998: Paul D Robbins; Christopher H Evans; Y Chernajovsky
Gene therapy for rheumatoid arthritis.
Springer seminars in immunopathology 1998;20(1-2):197-209.
1998: D Jaffurs; Christopher H Evans
The Human Genome Project: implications for the treatment of musculoskeletal disease.
The Journal of the American Academy of Orthopaedic Surgeons 1998;6(1):1-14.
1998: M Cao; Maja Stefanovic-Racic; Helga I Georgescu; LA Miller; Christopher H Evans
Generation of nitric oxide by lapine meniscal cells and its effect on matrix metabolism: stimulation of collagen production by arginine.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1998;16(1):104-11.
1997: M Cameron; A Buchgraber; H Passler; Molly Vogt; E Thonar; Freddie Fu; Christopher H Evans
The natural history of the anterior cruciate ligament-deficient knee. Changes in synovial fluid cytokine and keratan sulfate concentrations.
The American journal of sports medicine 1997;25(6):751-4.
1997: Steven C Ghivizzani; Richard Kang; Helga I Georgescu; Eric R Lechman; D Jaffurs; J M Engle; simon simon watkins; M H Tindal; M K Suchanek; L R McKenzie; Christopher H Evans; Paul D Robbins
Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3604-12.
1997: Julio A Reinecke; Peter Wehling; P Robbins; Christopher H Evans; M Sager; G Schulze-Allen; H Koch
[In vitro transfer of genes in spinal tissue].
Zeitschrift für Orthopädie und ihre Grenzgebiete 1997;135(5):412-6.
1997: Steven C Ghivizzani; Eric R Lechman; C Tio; Karen Mulé; Sunil Chada; JE McCormack; Christopher H Evans; Paul D Robbins
Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy.
Gene therapy 1997;4(9):977-82.
1997: J M Engle; Helga I Georgescu; Christopher H Evans
Interleukin-1 alpha as an autocrine regulator in rabbit synovial fibroblasts.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46 Suppl 2():S175-6.
1997: M L Balk; J Bray; C Day; Michael W Epperly; Joel S Greenberger; Christopher H Evans; Christopher Niyibizi
Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim).
Bone 1997;21(1):7-15.
1997: Torsten G Gerich; S Ghivizani; Freddie H Fu; Paul D Robbins; Christopher H Evans
[Gene transfer into the patellar tendon of rabbits: a preliminary study of locoregional expression of growth factors].
Wiener klinische Wochenschrift 1997;109(11):384-9.
1997: M Cao; A Westerhausen-Larson; Christopher Niyibizi; KW Kavalkovich; Helga I Georgescu; C F Rizzo; Patricia A Hebda; Maja Stefanovic-Racic; Christopher H Evans
Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: prolyl hydroxylase as a possible target.
The Biochemical journal 1997;324 ( Pt 1)():305-10.
1997: Peter Wehling; KP Schulitz; Paul D Robbins; Christopher H Evans; Julio A Reinecke
Transfer of genes to chondrocytic cells of the lumbar spine. Proposal for a treatment strategy of spinal disorders by local gene therapy.
Spine 1997;22(10):1092-7.
1997: James D Kang; Maja Stefanovic-Racic; L A McIntyre; Helga I Georgescu; Christopher H Evans
Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases.
Spine 1997;22(10):1065-73.
1997: Torsten G Gerich; Philipp Lobenhoffer; Freddie H Fu; Paul D Robbins; Christopher H Evans
[Possibilities of gene therapy in traumatic and degenerative articular lesions. Current status of experimental and initial clinical applications].
Der Orthopäde 1997;26(5):450-8.
1997: Maja Stefanovic-Racic; M O Möllers; LA Miller; Christopher H Evans
Nitric oxide and proteoglycan turnover in rabbit articular cartilage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1997;15(3):442-9.
1997: Richard Kang; Steven C Ghivizzani; James H Herndon; Paul D Robbins; Christopher H Evans
Gene therapy for arthritis: principles and clinical practice.
Biochemical Society transactions 1997;25(2):533-7.
1997: Richard Kang; T Marui; Steven C Ghivizzani; I M Nita; Helga I Georgescu; Jun-Kyo Francis Suh; Paul D Robbins; Christopher H Evans
Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: a feasibility study.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1997;5(2):139-43.
1997: Lesley A Doughty; Ken Patrene; Christopher H Evans; SS Boggs; Paul D Robbins
Constitutive systemic expression of IL-1Ra or soluble TNF receptor by genetically modified hematopoietic cells suppresses LPS induction of IL-6 and IL-10.
Gene therapy 1997;4(3):252-7.
1997: S C Scherping; C C Schmidt; Helga I Georgescu; C K Kwoh; Christopher H Evans; Savio L-Y. Woo
Effect of growth factors on the proliferation of ligament fibroblasts from skeletally mature rabbits.
Connective tissue research 1997;36(1):1-8.
1997: Torsten G Gerich; R Kang; Freddie H Fu; Paul D Robbins; Christopher H Evans
Gene transfer to the patellar tendon.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 1997;5(2):118-23.
1996: Torsten G Gerich; Richard Kang; Freddie H Fu; Paul D Robbins; Christopher H Evans
Gene transfer to the rabbit patellar tendon: potential for genetic enhancement of tendon and ligament healing.
Gene therapy 1996;3(12):1089-93.
1996: Christopher H Evans; Paul D Robbins; Steven C Ghivizzani; James H Herndon; Richard Kang; Alfred B Bahnson; John A Barranger; E M Elders; S Gay; Matthew M Tomaino; Mary Chester Wasko; simon simon watkins; Theresa L Whiteside; Joseph C Glorioso; Michael T Lotze; T M Wright
Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis.
Human gene therapy 1996;7(10):1261-80.
1996: I Nita; Steven C Ghivizzani; J Galea-Lauri; G Bandara; Helga I Georgescu; Paul D Robbins; Christopher H Evans
Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo.
Arthritis and rheumatism 1996;39(5):820-8.
1996: K Otani; I Nita; William Macaulay; Helga I Georgescu; Paul D Robbins; Christopher H Evans
Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(9):3558-62.
1996: Peter Wehling; S J Cleveland; K Heininger; KP Schulitz; Julio A Reinecke; Christopher H Evans
Neurophysiologic changes in lumbar nerve root inflammation in the rat after treatment with cytokine inhibitors. Evidence for a role of interleukin-1.
Spine 1996;21(8):931-5.
1996: C W Lin; P D Robbins; Helga I Georgescu; Christopher H Evans
Effects of immortalization upon the induction of matrix metalloproteinases in rabbit synovial fibroblasts.
Experimental cell research 1996;223(1):117-26.
1996: James D Kang; Helga I Georgescu; L McIntyre-Larkin; Maja Stefanovic-Racic; William F Donaldson; Christopher H Evans
Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2.
Spine 1996;21(3):271-7.
1996: Maja Stefanovic-Racic; T I Morales; D Taskiran; L A McIntyre; Christopher H Evans
The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(3):1213-20.
1996: Torsten G Gerich; Freddie H Fu; Paul D Robbins; Christopher H Evans
Prospects for gene therapy in sports medicine.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 1996;4(3):180-7.
1996: Christopher H Evans; Paul D Robbins
The promise of a new clinical trial--intra-articular IL-1 receptor antagonist.
Proceedings of the Association of American Physicians 1996;108(1):1-5.
1996: Christopher H Evans; simon simon watkins; M Stefanović-Racić
Nitric oxide and cartilage metabolism.
Methods in enzymology 1996;269():75-88.
1996: Steven T DeKosky; Scot D Styren; Mark E O'Malley; James R Goss; Patrick M Kochanek; D Marion; Christopher H Evans; Paul D Robbins
Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain.
Annals of neurology 1996;39(1):123-7.
1995: James D Kang; Helga I Georgescu; L McIntyre-Larkin; Maja Stefanovic-Racic; Christopher H Evans
Herniated cervical intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2.
Spine 1995;20(22):2373-8.
1995: SS Boggs; Ken Patrene; G M Mueller; Christopher H Evans; Lesley A Doughty; Paul D Robbins
Prolonged systemic expression of human IL-1 receptor antagonist (hIL-1ra) in mice reconstituted with hematopoietic cells transduced with a retrovirus carrying the hIL-1ra cDNA.
Gene therapy 1995;2(9):632-8.
1995: Maja Stefanovic-Racic; K Meyers; C Meschter; J W Coffey; Rosemary A Hoffman; Christopher H Evans
Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis.
The Journal of rheumatology 1995;22(10):1922-8.
1995: Maja Stefanovic-Racic; D Taskiran; Helga I Georgescu; Christopher H Evans
Modulation of chondrocyte proteoglycan synthesis by endogeneously produced nitric oxide.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1995;44 Suppl 2():S216-7.
1995: Christopher H Evans; Paul D Robbins
Possible orthopaedic applications of gene therapy.
The Journal of bone and joint surgery. American volume 1995;77(7):1103-14.
1995: C C Schmidt; Helga I Georgescu; C K Kwoh; G L Blomstrom; C P Engle; L A Larkin; Christopher H Evans; Savio L-Y. Woo
Effect of growth factors on the proliferation of fibroblasts from the medial collateral and anterior cruciate ligaments.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1995;13(2):184-90.
1995: Christopher H Evans; Maja Stefanovic-Racic; J Lancaster
Nitric oxide and its role in orthopaedic disease.
Clinical orthopaedics and related research 1995;(312):275-94.
1995: Christopher H Evans
Nitric oxide: what role does it play in inflammation and tissue destruction?
Agents and actions. Supplements 1995;47():107-16.
1994: Christopher H Evans; Peter Wehling; Julio A Reinecke
[Perspectives in gene therapy in rheumatic and degenerative diseases of the spine and joints].
Zeitschrift für Orthopädie und ihre Grenzgebiete 1994;132(6):449-52.
1994: Maja Stefanovic-Racic; J Stadler; Helga I Georgescu; Christopher H Evans
Nitric oxide synthesis and its regulation by rabbit synoviocytes.
The Journal of rheumatology 1994;21(10):1892-8.
1994: Maja Stefanovic-Racic; K Meyers; C Meschter; J W Coffey; Rosemary A Hoffman; Christopher H Evans
N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats.
Arthritis and rheumatism 1994;37(7):1062-9.
1994: Maja Stefanovic-Racic; J Stadler; Helga I Georgescu; Christopher H Evans
Nitric oxide and energy production in articular chondrocytes.
Journal of cellular physiology 1994;159(2):274-80.
1994: P E Greis; Helga I Georgescu; Freddie H Fu; Christopher H Evans
Particle-induced synthesis of collagenase by synovial fibroblasts: an immunocytochemical study.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1994;12(2):286-93.
1994: Christopher H Evans; Paul D Robbins
The interleukin-1 receptor antagonist and its delivery by gene transfer.
Receptor 1994;4(1):9-15.
1994: G L Hung; J Galea-Lauri; G M Mueller; Helga I Georgescu; L A Larkin; M K Suchanek; M H Tindal; Paul D Robbins; Christopher H Evans
Suppression of intra-articular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium.
Gene therapy 1994;1(1):64-9.
1993: G Bandara; G M Mueller; J Galea-Lauri; M H Tindal; Helga I Georgescu; M K Suchanek; G L Hung; Joseph C Glorioso; Paul D Robbins; Christopher H Evans
Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10764-8.
1993: Maja Stefanovic-Racic; J Stadler; Christopher H Evans
Nitric oxide and arthritis.
Arthritis and rheumatism 1993;36(8):1036-44.
1993: V J Silvaggio; Freddie H Fu; Helga I Georgescu; Christopher H Evans
The induction of IL-1 by freeze-dried ethylene oxide-treated bone-patellar tendon-bone allograft wear particles: an in vitro study.
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 1993;9(1):82-6.
1993: C W Lin; Helga I Georgescu; Christopher H Evans
The role of AP-1 in matrix metalloproteinase gene expression.
Agents and actions 1993;39 Spec No():C215-8.
1992: Christopher H Evans; G Bandara; G Mueller; Paul Robbins; Joseph C Glorioso; Helga I Georgescu
Synovial cell transplants for gene transfer to joints.
Transplantation proceedings 1992;24(6):2966.
1992: K I Hulkower; R Sagi-Eisenberg; Linton Traub; Helga I Georgescu; Christopher H Evans
Synovial protein kinase C and its apparent insensitivity to interleukin-1.
European journal of biochemistry / FEBS 1992;209(1):81-8.
1992: G Bandara; C W Lin; Helga I Georgescu; Christopher H Evans
The synovial activation of chondrocytes: evidence for complex cytokine interactions involving a possible novel factor.
Biochimica et biophysica acta 1992;1134(3):309-18.
1992: G Bandara; Paul D Robbins; Helga I Georgescu; G M Mueller; Joseph C Glorioso; Christopher H Evans
Gene transfer to synoviocytes: prospects for gene treatment of arthritis.
DNA and cell biology 1992;11(3):227-31.
1991: J Stadler; Maja Stefanovic-Racic; Timothy R Billiar; R D Curran; L A McIntyre; Helga I Georgescu; Richard L Simmons; Christopher H Evans
Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3915-20.
1991: Christopher H Evans; Helga I Georgescu; C W Lin; D Mendelow; David Steed; M W Webster
Inducible synthesis of collagenase and other neutral metalloproteinases by cells of aortic origin.
The Journal of surgical research 1991;51(5):399-404.
1991: G Bandara; Helga I Georgescu; C W Lin; Christopher H Evans
Synovial activation of chondrocytes: evidence for complex cytokine interactions.
Agents and actions 1991;34(1-2):285-8.
1991: K I Hulkower; R Sagi-Eisenberg; Linton Traub; Helga I Georgescu; Christopher H Evans
Interleukin-1 and synovial protein kinase C: identification of a novel, 35 kDa cytosolic substrate.
Agents and actions 1991;34(1-2):278-81.
1991: M E Baratz; Helga I Georgescu; Christopher H Evans
Studies on the autocrine activation of a synovial cell line.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1991;9(5):651-7.
1991: Marshall W Webster; C E McAuley; David Steed; D D Miller; Christopher H Evans
Collagen stability and collagenolytic activity in the normal and aneurysmal human abdominal aorta.
American journal of surgery 1991;161(6):635-8.
1991: K I Hulkower; Helga I Georgescu; Christopher H Evans
Evidence that responses of articular chondrocytes to interleukin-1 and basic fibroblast growth factor are not mediated by protein kinase C.
The Biochemical journal 1991;276 ( Pt 1)():157-62.
1991: K I Hulkower; Christopher H Evans
Protein phosphorylation and metalloproteinase synthesis by lapine articular chondrocytes.
The Journal of rheumatology. Supplement 1991;27():110-3.
1989: K I Hulkower; H I Georgscu; Christopher H Evans
Altered patterns of protein phosphorylation in articular chondrocytes treated with interleukin-1 or synovial cytokines.
FEBS letters 1989;257(2):228-32.
1989: G Bandara; C W Lin; Helga I Georgescu; D Mendelow; Christopher H Evans
Chondrocyte activation by interleukin-1: analysis of the synergistic properties of fibroblast growth factor and phorbol myristate acetate.
Archives of biochemistry and biophysics 1989;274(2):539-47.
1989: K I Hulkower; Helga I Georgescu; Christopher H Evans
Protein kinase C and chondrocyte activation.
Agents and actions 1989;27(3-4):442-4.
1989: C W Lin; Helga I Georgescu; S L Phillips; Christopher H Evans
Cycloheximide inhibits the induction of collagenase mRNA in chondrocytes exposed to synovial factors or recombinant interleukin-1.
Agents and actions 1989;27(3-4):445-7.
1989: G Bandara; C W Lin; Helga I Georgescu; D Mendelow; Christopher H Evans
Chondrocyte activation by interleukin-1: synergism with fibroblast growth factor and phorbol myristate acetate.
Agents and actions 1989;27(3-4):439-41.
1989: S Watanabe; Helga I Georgescu; D B Kuhns; Christopher H Evans
Chondrocyte activation by a putative interleukin-1 derived from lapine polymorphonuclear leukocytes.
Archives of biochemistry and biophysics 1989;270(1):69-76.
1988: E J Olson; James D Kang; Freddie H Fu; Helga I Georgescu; G C Mason; Christopher H Evans
The biochemical and histological effects of artificial ligament wear particles: in vitro and in vivo studies.
The American journal of sports medicine 1988;16(6):558-70.
1988: Helga I Georgescu; D Mendelow; Christopher H Evans
HIG-82: an established cell line from rabbit periarticular soft tissue, which retains the "activatable" phenotype.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1988;24(10):1015-22.
1988: K Sung; D Mendelow; Helga I Georgescu; Christopher H Evans
Characterisation of chondrocyte activation in response to cytokines synthesised by a synovial cell line.
Biochimica et biophysica acta 1988;971(2):148-56.
1988: C W Lin; S L Phillips; C E Brinckerhoff; Helga I Georgescu; G Bandara; Christopher H Evans
Induction of collagenase mRNA in lapine articular chondrocytes by synovial factors and interleukin-1.
Archives of biochemistry and biophysics 1988;264(1):351-4.
1988: R J Boniface; P R Cain; Christopher H Evans
Articular responses to purified cartilage proteoglycans.
Arthritis and rheumatism 1988;31(2):258-66.
1988: G M Ferguson; S Watanabe; Helga I Georgescu; Christopher H Evans
The synovial production of collagenase and chondrocyte activating factors in response to cobalt.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1988;6(4):525-30.
1986: S Watanabe; Helga I Georgescu; D Mendelow; Christopher H Evans
Chondrocyte activation in response to factor(s) produced by a continuous line of lapine synovial fibroblasts.
Experimental cell research 1986;167(1):218-26.