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William Evans

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Disorders

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Chemicals & Drugs

Living Beings

Infant

Procedures

Concepts & Ideas

Occupations

Pharmacogenetics

Physiology

Phenomena

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Publications

TOP 3
Jeha S; Pei D; Raimondi S C; Onciu M; Campana D; Cheng C; Sandlund J T; Ribeiro R C; Rubnitz J E; Howard S C; Downing J R; Evans W E; Relling M V; Pui C-H
Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1.
Pui Ching-Hon; Campana Dario; Pei Deqing; Bowman W Paul; Sandlund John T; Kaste Sue C; Ribeiro Raul C; Rubnitz Jeffrey E; Raimondi Susana C; Onciu Mihaela; Coustan-Smith Elaine; Kun Larry E; Jeha Sima; Cheng Cheng; Howard Scott C; Simmons Vickey; Bayles Amy; Metzger Monika L; Boyett James M; Leung Wing; Handgretinger Rupert; Downing James R; Evans William E; Relling Mary V
Treating childhood acute lymphoblastic leukemia without cranial irradiation.
French Deborah; Yang Wenjian; Cheng Cheng; Raimondi Susana C; Mullighan Charles G; Downing James R; Evans William E; Pui Ching-Hon; Relling Mary V
Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.

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All Publications

2009: Jeha S; Pei D; Raimondi S C; Onciu M; Campana D; Cheng C; Sandlund J T; Ribeiro R C; Rubnitz J E; Howard S C; Downing J R; Evans W E; Relling M V; Pui C-H
Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2009;23(8):1406-9.
2009: Pui Ching-Hon; Campana Dario; Pei Deqing; Bowman W Paul; Sandlund John T; Kaste Sue C; Ribeiro Raul C; Rubnitz Jeffrey E; Raimondi Susana C; Onciu Mihaela; Coustan-Smith Elaine; Kun Larry E; Jeha Sima; Cheng Cheng; Howard Scott C; Simmons Vickey; Bayles Amy; Metzger Monika L; Boyett James M; Leung Wing; Handgretinger Rupert; Downing James R; Evans William E; Relling Mary V
Treating childhood acute lymphoblastic leukemia without cranial irradiation.
The New England journal of medicine 2009;360(26):2730-41.
2009: French Deborah; Yang Wenjian; Cheng Cheng; Raimondi Susana C; Mullighan Charles G; Downing James R; Evans William E; Pui Ching-Hon; Relling Mary V
Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.
Blood 2009;113(19):4512-20.
2009: Den Boer Monique L; van Slegtenhorst Marjon; De Menezes Renée X; Cheok Meyling H; Buijs-Gladdines Jessica G C A M; Peters Susan T C J M; Van Zutven Laura J C M; Beverloo H Berna; Van der Spek Peter J; Escherich Gaby; Horstmann Martin A; Janka-Schaub Gritta E; Kamps Willem A; Evans William E; Pieters Rob
A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study.
The lancet oncology 2009;10(2):125-34.
2009: Hulleman Esther; Kazemier Karin M; Holleman Amy; VanderWeele David J; Rudin Charles M; Broekhuis Mathilde J C; Evans William E; Pieters Rob; Den Boer Monique L
Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells.
Blood 2009;113(9):2014-21.
2009: Yang Jun J; Cheng Cheng; Yang Wenjian; Pei Deqing; Cao Xueyuan; Fan Yiping; Pounds Stanley B; Neale Geoffrey; Treviño Lisa R; French Deborah; Campana Dario; Downing James R; Evans William E; Pui Ching-Hon; Devidas Meenakshi; Bowman W P; Camitta Bruce M; Willman Cheryl L; Davies Stella M; Borowitz Michael J; Carroll William L; Hunger Stephen P; Relling Mary V
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
JAMA : the journal of the American Medical Association 2009;301(4):393-403.
2008: Yang Jun J; Bhojwani Deepa; Yang Wenjian; Cai Xiangjun; Stocco Gabriele; Crews Kristine; Wang Jinhua; Morrison Debra; Devidas Meenakshi; Hunger Stephen P; Willman Cheryl L; Raetz Elizabeth A; Pui Ching-Hon; Evans William E; Relling Mary V; Carroll William L
Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia.
Blood 2008;112(10):4178-83.
2008: Sorich Michael J; Pottier Nicolas; Pei Deqing; Yang Wenjian; Kager Leo; Stocco Gabriele; Cheng Cheng; Panetta John C; Pui Ching-Hon; Relling Mary V; Cheok Meyling H; Evans William E
In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile.
PLoS medicine 2008;5(4):e83.
2008: French Deborah; Yang Wenjian; Hamilton Leo H; Neale Geoffrey; Fan Yiping; Downing James R; Cox Nancy J; Pui Ching-Hon; Evans William E; Relling Mary V
Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs.
PloS one 2008;3(5):e2144.
2007: Pottier Nicolas; Cheok Meyling H; Yang Wenjian; Assem Mahfoud; Tracey Lorraine; Obenauer John C; Panetta John C; Relling Mary V; Evans William E
Expression of SMARCB1 modulates steroid sensitivity in human lymphoblastoid cells: identification of a promoter SNP that alters PARP1 binding and SMARCB1 expression.
Human molecular genetics 2007;16(19):2261-71.
2007: Hartford Christine; Vasquez Erick; Schwab Matthias; Edick Mathew J; Rehg Jerold E; Grosveld Gerard; Pui Ching-Hon; Evans William E; Relling Mary V
Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics.
Cancer research 2007;67(10):4965-72.
2007: Jones T S; Yang W; Evans W E; Relling M V
Using HapMap tools in pharmacogenomic discovery: the thiopurine methyltransferase polymorphism.
Clinical pharmacology and therapeutics 2007;81(5):729-34.
2007: Kishi Shinji; Cheng Cheng; French Deborah; Pei Deqing; Das Soma; Cook Edwin H; Hijiya Nobuko; Rizzari Carmelo; Rosner Gary L; Frudakis Tony; Pui Ching-Hon; Evans William E; Relling Mary V
Ancestry and pharmacogenetics of antileukemic drug toxicity.
Blood 2007;109(10):4151-7.
2007: Evans William E
Creating an infrastructure for pediatric oncology drug development.
Clinical advances in hematology & oncology : H&O 2007;5(3):198-200.
2007: Hijiya Nobuko; Hudson Melissa M; Lensing Shelly; Zacher Margie; Onciu Mihaela; Behm Fred G; Razzouk Bassem I; Ribeiro Raul C; Rubnitz Jeffrey E; Sandlund John T; Rivera Gaston K; Evans William E; Relling Mary V; Pui Ching-Hon
Cumulative incidence of secondary neoplasms as a first event after childhood acute lymphoblastic leukemia.
JAMA : the journal of the American Medical Association 2007;297(11):1207-15.
2006: Pui Ching-Hon; Relling Mary V; Evans William E
Is mega dose of methotrexate beneficial to patients with acute lymphoblastic leukemia?
Leukemia & lymphoma 2006;47(12):2431-2.
2006: Nasedkina Tatyana V; Fedorova Olga E; Glotov Andrei S; Chupova Natalia V; Samochatova Elena V; Maiorova Olga A; Zemlyakova Valeria V; Roudneva Anastasia E; Chudinov Alexander V; Yurasov Roman A; Kozhekbaeva Janna M; Barsky Victor E; Krynetskiy Eugene Y; Krynetskaia Natalia F; Cheng Cheng; Ribeiro Raul C; Evans William E; Roumyantsev Alexander G; Zasedatelev Alexander S
Rapid genotyping of common deficient thiopurine S-methyltransferase alleles using the DNA-microchip technique.
European journal of human genetics : EJHG 2006;14(9):991-8.
2006: Holleman Amy; den Boer Monique L; Cheok Meyling H; Kazemier Karin M; Pei Deqing; Downing James R; Janka-Schaub Gritta E; Göbel Ulrich; Graubner Ulrike B; Pui Ching-Hon; Evans William E; Pieters Rob
Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols.
Blood 2006;108(6):1984-90.
2006: Cheok Meyling H; Evans William E
Acute lymphoblastic leukaemia: a model for the pharmacogenomics of cancer therapy.
Nature reviews. Cancer 2006;6(2):117-29.
2006: Panetta J C; Evans W E; Cheok M H
Mechanistic mathematical modelling of mercaptopurine effects on cell cycle of human acute lymphoblastic leukaemia cells.
British journal of cancer 2006;94(1):93-100.
2006: Holleman Amy; den Boer Monique L; de Menezes Renée X; Cheok Meyling H; Cheng Cheng; Kazemier Karin M; Janka-Schaub Gritta E; Göbel Ulrich; Graubner Ulrike B; Evans William E; Pieters Rob
The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia.
Blood 2006;107(2):769-76.
2006: Cheok Meyling H; Lugthart Sanne; Evans William E
Pharmacogenomics of acute leukemia.
Annual review of pharmacology and toxicology 2006;46():317-53.
2005: Evans William E
Gene expression microarrays as a prognostic test.
Clinical advances in hematology & oncology : H&O 2005;3(12):902-4.
2005: Pui Ching-Hon; Pei Deqing; Sandlund John T; Campana Dario; Ribeiro Raul C; Razzouk Bassem I; Rubnitz Jeffrey E; Howard Scott C; Hijiya Nobuko; Jeha Sima; Cheng Cheng; Downing James R; Evans William E; Relling Mary V; Hudson Melissa
Risk of adverse events after completion of therapy for childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(31):7936-41.
2005: Zaza Gianluigi; Cheok Meyling; Yang Wenjian; Panetta John C; Pui Ching-Hon; Relling Mary V; Evans William E
Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment.
Blood 2005;106(5):1778-85.
2005: French Deborah; Wilkinson Mark R; Yang Wenjian; de Chaisemartin Luc; Cook Edwin H; Das Soma; Ratain Mark J; Evans William E; Downing James R; Pui Ching-Hon; Relling Mary V
Global gene expression as a function of germline genetic variation.
Human molecular genetics 2005;14(12):1621-9.
2005: Stams Wendy A G; den Boer Monique L; Holleman Amy; Appel Inge M; Beverloo H Berna; van Wering Elisabeth R; Janka-Schaub Gritta E; Evans William E; Pieters Rob
Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia.
Blood 2005;105(11):4223-5.
2005: Rocha Jose Claudio C; Cheng Cheng; Liu Wei; Kishi Shinji; Das Soma; Cook Edwin H; Sandlund John T; Rubnitz Jeffrey; Ribeiro Raul; Campana Dario; Pui Ching-Hon; Evans William E; Relling Mary V
Pharmacogenetics of outcome in children with acute lymphoblastic leukemia.
Blood 2005;105(12):4752-8.
2005: Lugthart Sanne; Cheok Meyling H; den Boer Monique L; Yang Wenjian; Holleman Amy; Cheng Cheng; Pui Ching-Hon; Relling Mary V; Janka-Schaub Gritta E; Pieters Rob; Evans William E
Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.
Cancer cell 2005;7(4):375-86.
2005: Edick Mathew J; Cheng Cheng; Yang Wenjian; Cheok Meyling; Wilkinson Mark R; Pei Deqing; Evans William E; Kun Larry E; Pui Ching-Hon; Relling Mary V
Lymphoid gene expression as a predictor of risk of secondary brain tumors.
Genes, chromosomes & cancer 2005;42(2):107-16.
2005: Kager Leo; Cheok Meyling; Yang Wenjian; Zaza Gianluigi; Cheng Qing; Panetta John C; Pui Ching-Hon; Downing James R; Relling Mary V; Evans William E
Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics.
The Journal of clinical investigation 2005;115(1):110-7.
2005: Rivera Gaston K; Zhou Yinmei; Hancock Michael L; Gajjar Amar; Rubnitz Jeffrey; Ribeiro Raul C; Sandlund John T; Hudson Melissa; Relling Mary; Evans William E; Pui Ching-Hon
Bone marrow recurrence after initial intensive treatment for childhood acute lymphoblastic leukemia.
Cancer 2005;103(2):368-76.
2004: Pui Ching-Hon; Sandlund John T; Pei Deqing; Campana Dario; Rivera Gaston K; Ribeiro Raul C; Rubnitz Jeffrey E; Razzouk Bassem I; Howard Scott C; Hudson Melissa M; Cheng Cheng; Kun Larry E; Raimondi Susana C; Behm Frederick G; Downing James R; Relling Mary V; Evans William E;
Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital.
Blood 2004;104(9):2690-6.
2004: Zaza Gianluigi; Yang Wenjian; Kager Leo; Cheok Meyling; Downing James; Pui Ching-Hon; Cheng Cheng; Relling Mary V; Evans William E
Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis.
Blood 2004;104(5):1435-41.
2004: Holleman Amy; Cheok Meyling H; den Boer Monique L; Yang Wenjian; Veerman Anjo J P; Kazemier Karin M; Pei Deqing; Cheng Cheng; Pui Ching-Hon; Relling Mary V; Janka-Schaub Gritta E; Pieters Rob; Evans William E
Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment.
The New England journal of medicine 2004;351(6):533-42.
2004: Cheng Qing; Wu Bainan; Kager Leo; Panetta J Carl; Zheng Jie; Pui Ching-Hon; Relling Mary V; Evans William E
A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells.
Pharmacogenetics 2004;14(8):557-67.
2004: Krynetskiy Eugene Y; Evans William E
Closing the gap between science and clinical practice: the thiopurine S-methyltransferase polymorphism moves forward.
Pharmacogenetics 2004;14(7):395-6.
2004: Pui C-H; Schrappe M; Masera G; Nachman J; Gadner H; Eden O B; Evans W E; Gaynon P;
Ponte di Legno Working Group: statement on the right of children with leukemia to have full access to essential treatment and report on the Sixth International Childhood Acute Lymphoblastic Leukemia Workshop.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2004;18(6):1043-53.
2004: Evans William E; Relling Mary V
Moving towards individualized medicine with pharmacogenomics.
Nature 2004;429(6990):464-8.
2004: Brown Victor M; Krynetski Eugene Y; Krynetskaia Natalia F; Grieger Dara; Mukatira Suraj T; Murti Kuruganti G; Slaughter Clive A; Park Hee-Won; Evans William E
A novel CRM1-mediated nuclear export signal governs nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase following genotoxic stress.
The Journal of biological chemistry 2004;279(7):5984-92.
2003: Krynetski Eugene; Evans William E
Drug methylation in cancer therapy: lessons from the TPMT polymorphism.
Oncogene 2003;22(47):7403-13.
2003: Pui Ching-Hon; Sandlund John T; Pei Deqing; Rivera Gaston K; Howard Scott C; Ribeiro Raul C; Rubnitz Jeffrey E; Razzouk Bassem I; Hudson Melissa M; Cheng Cheng; Raimondi Susana C; Behm Frederick G; Downing James R; Relling Mary V; Evans William E
Results of therapy for acute lymphoblastic leukemia in black and white children.
JAMA : the journal of the American Medical Association 2003;290(15):2001-7.
2003: Pui Ching-Hon; Cheng Cheng; Leung Wing; Rai Shesh N; Rivera Gaston K; Sandlund John T; Ribeiro Raul C; Relling Mary V; Kun Larry E; Evans William E; Hudson Melissa M
Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia.
The New England journal of medicine 2003;349(7):640-9.
2003: Krynetskaia Natalia F; Brenner Timothy L; Krynetski Eugene Y; Du Weinan; Panetta John C; Ching-Hon Pui; Evans William E
Msh2 deficiency attenuates but does not abolish thiopurine hematopoietic toxicity in msh2-/- mice.
Molecular pharmacology 2003;64(2):456-65.
2003: Dervieux Thierry; Hancock Michael L; Pui Ching-Hon; Rivera Gaston K; Sandlund John T; Ribeiro Raul C; Boyett James; Evans William E; Relling Mary V
Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia.
Clinical pharmacology and therapeutics 2003;73(6):506-16.
2003: Cheok Meyling H; Yang Wenjian; Pui Ching-Hon; Downing James R; Cheng Cheng; Naeve Clayton W; Relling Mary V; Evans William E
Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells.
Nature genetics 2003;34(1):85-90.
2003: Relling Mary V; Boyett James M; Blanco Javier G; Raimondi Susana; Behm Frederick G; Sandlund John T; Rivera Gaston K; Kun Larry E; Evans William E; Pui Ching-Hon
Granulocyte colony-stimulating factor and the risk of secondary myeloid malignancy after etoposide treatment.
Blood 2003;101(10):3862-7.
2003: Evans William E; Cheok Meyling; Yang Wenjian; Sherr Charles J
Expression arrays illuminate a way forward for mantle cell lymphoma.
Cancer cell 2003;3(2):100-2.
2003: Krynetski Eugene Y; Krynetskaia Natalia F; Bianchi Marco E; Evans William E
A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues.
Cancer research 2003;63(1):100-6.
2003: Somerville Lilla; Krynetski Eugene Y; Krynetskaia Natalia F; Beger Richard D; Zhang Weixing; Marhefka Craig A; Evans William E; Kriwacki Richard W
Structure and dynamics of thioguanine-modified duplex DNA.
The Journal of biological chemistry 2003;278(2):1005-11.
2002: Pui Ching Hon; Relling Mary V; Evans William E
Role of pharmacogenomics and pharmacodynamics in the treatment of acute lymphoblastic leukaemia.
Best practice & research. Clinical haematology 2002;15(4):741-56.
2002: Panetta John Carl; Yanishevski Yuri; Pui Ching-Hon; Sandlund John T; Rubnitz Jeffrey; Rivera Gaston K; Ribeiro Raul; Evans William E; Relling Mary V
A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia.
Cancer chemotherapy and pharmacology 2002;50(5):419-28.
2002: Evans William E
Thiopurine S-methyltransferase: a genetic polymorphism that affects a small number of drugs in a big way.
Pharmacogenetics 2002;12(6):421-3.
2002: Dervieux Thierry; Brenner Timothy L; Hon Yuen Y; Zhou Yinmei; Hancock Michael L; Sandlund John T; Rivera Gaston K; Ribeiro Raul C; Boyett James M; Pui Ching-Hon; Relling Mary V; Evans William E
De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo.
Blood 2002;100(4):1240-7.
2002: Pui Ching-Hon; Relling Mary V; Campana Dario; Evans William E
Childhood acute lymphoblastic leukemia.
Reviews in clinical and experimental hematology 2002;6(2):161-80; discussion 200-2.
2002: Evans William E
Comprehensive assessment of thiopurine S-methyltransferase (TPMT) alleles in three ethnic populations.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 2002;24(5):335-6.
2002: Evans William E
Differing effects of methylenetetrahydrofolate reductase single nucleotide polymorphisms on methotrexate efficacy and toxicity in rheumatoid arthritis.
Pharmacogenetics 2002;12(3):181-2.
2002: Yeoh Eng-Juh; Ross Mary E; Shurtleff Sheila A; Williams W Kent; Patel Divyen; Mahfouz Rami; Behm Fred G; Raimondi Susana C; Relling Mary V; Patel Anami; Cheng Cheng; Campana Dario; Wilkins Dawn; Zhou Xiaodong; Li Jinyan; Liu Huiqing; Pui Ching-Hon; Evans William E; Naeve Clayton; Wong Limsoon; Downing James R
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.
Cancer cell 2002;1(2):133-43.
2002: McDonald Oliver G; Krynetski Eugene Y; Evans William E
Molecular haplotyping of genomic DNA for multiple single-nucleotide polymorphisms located kilobases apart using long-range polymerase chain reaction and intramolecular ligation.
Pharmacogenetics 2002;12(2):93-9.
2002: Dervieux Thierry; Chu Yaqin; Su Yi; Pui Ching-Hon; Evans William E; Relling Mary V
HPLC determination of thiopurine nucleosides and nucleotides in vivo in lymphoblasts following mercaptopurine therapy.
Clinical chemistry 2002;48(1):61-8.
2001: Evans W E; Ingelman-Sundberg M
Resequencing the sulfotransferase SULT1 gene provides new insights, while illuminating challenges that lie ahead for pharmacogenomics.
Pharmacogenetics 2001;11(9):745-6.
2001: Leung W; Sandlund J T; Hudson M M; Zhou Y; Hancock M L; Zhu Y; Ribeiro R C; Rubnitz J E; Kun L E; Razzouk B; Evans W E; Pui C H
Second malignancy after treatment of childhood non-Hodgkin lymphoma.
Cancer 2001;92(7):1959-66.
2001: Krynetskaia N F; Feng J Y; Krynetski E Y; Garcia J V; Panetta J C; Anderson K S; Evans W E
Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(11):1902-8.
2001: Pui C H; Sallan S; Relling M V; Masera G; Evans W E
International Childhood Acute Lymphoblastic Leukemia Workshop: Sausalito, CA, 30 November-1 December 2000.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(5):707-15.
2001: Evans W E; Hon Y Y; Bomgaars L; Coutre S; Holdsworth M; Janco R; Kalwinsky D; Keller F; Khatib Z; Margolin J; Murray J; Quinn J; Ravindranath Y; Ritchey K; Roberts W; Rogers Z R; Schiff D; Steuber C; Tucci F; Kornegay N; Krynetski E Y; Relling M V
Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(8):2293-301.
2001: Krynetski E Y; Krynetskaia N F; Gallo A E; Murti K G; Evans W E
A novel protein complex distinct from mismatch repair binds thioguanylated DNA.
Molecular pharmacology 2001;59(2):367-74.
2001: Leung W; Ribeiro R C; Hudson M; Tong X; Srivastava D K; Rubnitz J E; Sandlund J T; Razzouk B I; Evans W E; Pui C H
Second malignancy after treatment of childhood acute myeloid leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(1):41-5.
2001: Evans W E; Johnson J A
Pharmacogenomics: the inherited basis for interindividual differences in drug response.
Annual review of genomics and human genetics 2001;2():9-39.
2000: Pui C H; Boyett J M; Rivera G K; Hancock M L; Sandlund J T; Ribeiro R C; Rubnitz J E; Behm F G; Raimondi S C; Gajjar A; Razzouk B; Campana D; Kun L E; Relling M V; Evans W E
Long-term results of Total Therapy studies 11, 12 and 13A for childhood acute lymphoblastic leukemia at St Jude Children's Research Hospital.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(12):2286-94.
2000: Gajjar A; Harrison P L; Sandlund J T; Rivera G K; Ribeiro R C; Rubnitz J E; Razzouk B; Relling M V; Evans W E; Boyett J M; Pui C H
Traumatic lumbar puncture at diagnosis adversely affects outcome in childhood acute lymphoblastic leukemia.
Blood 2000;96(10):3381-4.
2000: Relling M V; Pui C H; Sandlund J T; Rivera G K; Hancock M L; Boyett J M; Schuetz E G; Evans W E
Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemia.
Lancet 2000;356(9226):285-90.
2000: Leung W; Hudson M; Zhu Y; Rivera G K; Ribeiro R C; Sandlund J T; Bowman L C; Evans W E; Kun L; Pui C H
Late effects in survivors of infant leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(7):1185-90.
2000: Pui C H; Raimondi S C; Srivastava D K; Tong X; Behm F G; Razzouk B; Rubnitz J E; Sandlund J T; Evans W E; Ribeiro R
Prognostic factors in infants with acute myeloid leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(4):684-7.
2000: Woo M H; Hak L J; Storm M C; Sandlund J T; Ribeiro R C; Rivera G K; Rubnitz J E; Harrison P L; Wang B; Evans W E; Pui C H; Relling M V
Hypersensitivity or development of antibodies to asparaginase does not impact treatment outcome of childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(7):1525-32.
2000: Blanco J G; Harrison P L; Evans W E; Relling M V
Human cytochrome P450 maximal activities in pediatric versus adult liver.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(4):379-82.
1999: Relling M V; Hancock M L; Rivera G K; Sandlund J T; Ribeiro R C; Krynetski E Y; Pui C H; Evans W E
Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.
Journal of the National Cancer Institute 1999;91(23):2001-8.
1999: Tai H L; Fessing M Y; Bonten E J; Yanishevsky Y; d'Azzo A; Krynetski E Y; Evans W E
Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: mechanism for TPMT protein deficiency inherited by TPMT*2, TPMT*3A, TPMT*3B or TPMT*3C.
Pharmacogenetics 1999;9(5):641-50.
1999: Evans W E; Relling M V
Pharmacogenomics: translating functional genomics into rational therapeutics.
Science (New York, N.Y.) 1999;286(5439):487-91.
1999: Krynetskaia N F; Krynetski E Y; Evans W E
Human RNase H-mediated RNA cleavage from DNA-RNA duplexes is inhibited by 6-deoxythioguanosine incorporation into DNA.
Molecular pharmacology 1999;56(4):841-8.
1999: Relling M V; Rubnitz J E; Rivera G K; Boyett J M; Hancock M L; Felix C A; Kun L E; Walter A W; Evans W E; Pui C H
High incidence of secondary brain tumours after radiotherapy and antimetabolites.
Lancet 1999;354(9172):34-9.
1999: Korshunova G A; Krynetski E Y; Mtchedlidze M T; Agapkin D V; Evans W E; Krynetskaia N F
Synthesis of modified thiopurine nucleosides for structural characterization of human thiopurine S-methyltransferase.
Nucleosides & nucleotides 1999;18(6-7):1747-8.
1999: Relling M V; Hancock M L; Boyett J M; Pui C H; Evans W E
Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia.
Blood 1999;93(9):2817-23.
1999: Krynetski E Y; Evans W E
Pharmacogenetics as a molecular basis for individualized drug therapy: the thiopurine S-methyltransferase paradigm.
Pharmaceutical research 1999;16(3):342-9.
1999: Woo M H; Relling M V; Sonnichsen D S; Rivera G K; Pratt C B; Pui C H; Evans W E; Pappo A S
Phase I targeted systemic exposure study of paclitaxel in children with refractory acute leukemias.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(3):543-9.
1999: Pui C H; Boyett J M; Relling M V; Harrison P L; Rivera G K; Behm F G; Sandlund J T; Ribeiro R C; Rubnitz J E; Gajjar A; Evans W E
Sex differences in prognosis for children with acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(3):818-24.
1999: Belkov V M; Krynetski E Y; Schuetz J D; Yanishevski Y; Masson E; Mathew S; Raimondi S; Pui C H; Relling M V; Evans W E
Reduced folate carrier expression in acute lymphoblastic leukemia: a mechanism for ploidy but not lineage differences in methotrexate accumulation.
Blood 1999;93(5):1643-50.
1999: Hon Y Y; Fessing M Y; Pui C H; Relling M V; Krynetski E Y; Evans W E
Polymorphism of the thiopurine S-methyltransferase gene in African-Americans.
Human molecular genetics 1999;8(2):371-6.
1999: Rubnitz J E; Behm F G; Wichlan D; Ryan C; Sandlund J T; Ribeiro R C; Rivera G K; Hancock M L; Relling M V; Evans W E; Pui C H; Downing J R
Low frequency of TEL-AML1 in relapsed acute lymphoblastic leukemia supports a favorable prognosis for this genetic subgroup.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(1):19-21.
1999: Evans W E; Pui C H; Relling M V
Defining the optimal dosage of methotrexate for childhood acute lymphoblastic leukemia. New insights from the lab and clinic.
Advances in experimental medicine and biology 1999;457():537-41.
1999: Pui C H; Evans W E
Genetic abnormalities and drug resistance in acute lymphoblastic leukemia.
Advances in experimental medicine and biology 1999;457():383-9.
1998: Pui C H; Rubnitz J E; Hancock M L; Downing J R; Raimondi S C; Rivera G K; Sandlund J T; Ribeiro R C; Head D R; Relling M V; Evans W E; Behm F G
Reappraisal of the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(12):3768-73.
1998: Woo M H; Hak L J; Storm M C; Evans W E; Sandlund J T; Rivera G K; Wang B; Pui C H; Relling M V
Anti-asparaginase antibodies following E. coli asparaginase therapy in pediatric acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(10):1527-33.
1998: Fessing M Y; Krynetski E Y; Zambetti G P; Evans W E
Functional characterization of the human thiopurine S-methyltransferase (TPMT) gene promoter.
European journal of biochemistry / FEBS 1998;256(3):510-7.
1998: Pui C H; Evans W E; Gilbert J R
Meeting report: International Childhood ALL Workshop: Memphis, TN, 3-4 December 1997.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(8):1313-8.
1998: Rubnitz J E; Relling M V; Harrison P L; Sandlund J T; Ribeiro R C; Rivera G K; Thompson S J; Evans W E; Pui C H
Transient encephalopathy following high-dose methotrexate treatment in childhood acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(8):1176-81.
1998: Loennechen T; Yates C R; Fessing M Y; Relling M V; Krynetski E Y; Evans W E
Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans.
Clinical pharmacology and therapeutics 1998;64(1):46-51.
1998: Pui C H; Mahmoud H H; Rivera G K; Hancock M L; Sandlund J T; Behm F G; Head D R; Relling M V; Ribeiro R C; Rubnitz J E; Kun L E; Evans W E
Early intensification of intrathecal chemotherapy virtually eliminates central nervous system relapse in children with acute lymphoblastic leukemia.
Blood 1998;92(2):411-5.
1998: Krynetski E Y; Evans W E
Pharmacogenetics of cancer therapy: getting personal.
American journal of human genetics 1998;63(1):11-6.
1998: Fessing M Y; Belkov V M; Krynetski E Y; Evans W E
Molecular cloning and functional characterization of the cDNA encoding the murine thiopurine S-methyltransferase (TPMT).
FEBS letters 1998;424(3):143-5.
1998: Relling M V; Yanishevski Y; Nemec J; Evans W E; Boyett J M; Behm F G; Pui C H
Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(3):346-52.
1998: Hon Y Y; Evans W E
Making TDM work to optimize cancer chemotherapy: a multidisciplinary team approach.
Clinical chemistry 1998;44(2):388-400.
1998: Evans W E; Relling M V; Rodman J H; Crom W R; Boyett J M; Pui C H
Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia.
The New England journal of medicine 1998;338(8):499-505.
1998: Fessing M Y; Krynetski E Y; Schuetz J D; Evans W E
Structural and functional analysis of the human TPMT gene promoter.
Advances in experimental medicine and biology 1998;431():315-8.
1997: Krynetski E Y; Fessing M Y; Yates C R; Sun D; Schuetz J D; Evans W E
Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PAC1 genomic library.
Pharmaceutical research 1997;14(12):1672-8.
1997: Pui C H; Relling M V; Lascombes F; Harrison P L; Struxiano A; Mondesir J M; Ribeiro R C; Sandlund J T; Rivera G K; Evans W E; Mahmoud H H
Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(11):1813-6.
1997: Ribeiro R C; Broniscer A; Rivera G K; Hancock M L; Raimondi S C; Sandlund J T; Crist W; Evans W E; Pui C H
Philadelphia chromosome-positive acute lymphoblastic leukemia in children: durable responses to chemotherapy associated with low initial white blood cell counts.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(9):1493-6.
1997: Rubnitz J E; Behm F G; Pui C H; Evans W E; Relling M V; Raimondi S C; Harrison P L; Sandlund J T; Ribeiro R C; Grosveld G; Downing J R
Genetic studies of childhood acute lymphoblastic leukemia with emphasis on p16, MLL, and ETV6 gene abnormalities: results of St Jude Total Therapy Study XII.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(8):1201-6.
1997: Galpin A J; Schuetz J D; Masson E; Yanishevski Y; Synold T W; Barredo J C; Pui C H; Relling M V; Evans W E
Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity.
Molecular pharmacology 1997;52(1):155-63.
1997: Tai H L; Krynetski E Y; Schuetz E G; Yanishevski Y; Evans W E
Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):6444-9.
1997: Evans W E; Relling M V; Boyett J M; Pui C H
Does pharmacokinetic variability influence the efficacy of high-dose methotrexate for the treatment of children with acute lymphoblastic leukemia: what can we learn from small studies?
Leukemia research 1997;21(5):435-7.
1997: Yates C R; Krynetski E Y; Loennechen T; Fessing M Y; Tai H L; Pui C H; Relling M V; Evans W E
Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance.
Annals of internal medicine 1997;126(8):608-14.
1997: Rubnitz J E; Downing J R; Pui C H; Shurtleff S A; Raimondi S C; Evans W E; Head D R; Crist W M; Rivera G K; Hancock M L; Boyett J M; Buijs A; Grosveld G; Behm F G
TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognostic significance.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(3):1150-7.
1997: Chen C L; Liu Q; Pui C H; Rivera G K; Sandlund J T; Ribeiro R; Evans W E; Relling M V
Higher frequency of glutathione S-transferase deletions in black children with acute lymphoblastic leukemia.
Blood 1997;89(5):1701-7.
1996: Bosso J A; Liu Q; Evans W E; Relling M V
CYP2D6, N-acetylation, and xanthine oxidase activity in cystic fibrosis.
Pharmacotherapy 1996;16(5):749-53.
1996: Krynetski E Y; Tai H L; Yates C R; Fessing M Y; Loennechen T; Schuetz J D; Relling M V; Evans W E
Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms.
Pharmacogenetics 1996;6(4):279-90.
1996: Ito C; Evans W E; McNinch L; Coustan-Smith E; Mahmoud H; Pui C H; Campana D
Comparative cytotoxicity of dexamethasone and prednisolone in childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(8):2370-6.
1996: Pui C H; Ribeiro R C; Campana D; Raimondi S C; Hancock M L; Behm F G; Sandlund J T; Rivera G K; Evans W E; Crist W M; Krance R
Prognostic factors in the acute lymphoid and myeloid leukemias of infants.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1996;10(6):952-6.
1996: Furman W L; Baker S D; Pratt C B; Rivera G K; Evans W E; Stewart C F
Escalating systemic exposure of continuous infusion topotecan in children with recurrent acute leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(5):1504-11.
1996: Tai H L; Krynetski E Y; Yates C R; Loennechen T; Fessing M Y; Krynetskaia N F; Evans W E
Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.
American journal of human genetics 1996;58(4):694-702.
1996: Relling M V; Mahmoud H H; Pui C H; Sandlund J T; Rivera G K; Ribeiro R C; Crist W M; Evans W E
Etoposide achieves potentially cytotoxic concentrations in CSF of children with acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(2):399-404.
1996: Coustan-Smith E; Kitanaka A; Pui C H; McNinch L; Evans W E; Raimondi S C; Behm F G; Aricò M; Campana D
Clinical relevance of BCL-2 overexpression in childhood acute lymphoblastic leukemia.
Blood 1996;87(3):1140-6.
1996: Masson E; Synold T W; Relling M V; Schuetz J D; Sandlund J T; Pui C H; Evans W E
Allopurinol inhibits de novo purine synthesis in lymphoblasts of children with acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1996;10(1):56-60.
1996: Masson E; Relling M V; Synold T W; Liu Q; Schuetz J D; Sandlund J T; Pui C H; Evans W E
Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate.
The Journal of clinical investigation 1996;97(1):73-80.
1995: Murry D J; Crom W R; Reddick W E; Bhargava R; Evans W E
Liver volume as a determinant of drug clearance in children and adolescents.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(10):1110-6.
1995: McLeod H L; Krynetski E Y; Wilimas J A; Evans W E
Higher activity of polymorphic thiopurine S-methyltransferase in erythrocytes from neonates compared to adults.
Pharmacogenetics 1995;5(5):281-6.
1995: Stute N; Furman W L; Schell M; Evans W E
Pharmacokinetics of recombinant human granulocyte-macrophage colony-stimulating factor in children after intravenous and subcutaneous administration.
Journal of pharmaceutical sciences 1995;84(7):824-8.
1995: Myers D E; Yanishevski Y; Masson E; Irvin J D; Evans W E; Uckun F M
Favorable pharmacodynamic features and superior anti-leukemic activity of B43 (anti-CD19) immunotoxins containing two pokeweed antiviral protein molecules covalently linked to each monoclonal antibody molecule.
Leukemia & lymphoma 1995;18(1-2):93-102.
1995: Krynetski E Y; Krynetskaia N F; Yanishevski Y; Evans W E
Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase.
Molecular pharmacology 1995;47(6):1141-7.
1995: Uckun F M; Stewart C F; Reaman G; Chelstrom L M; Jin J; Chandan-Langlie M; Waddick K G; White J; Evans W E
In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukemia cells.
Blood 1995;85(10):2817-28.
1995: Wilimas J A; Wall J E; Fairclough D L; Dancy R; Griffin C; Karanth S; Wang W; Evans W E
A longitudinal study of granulocyte colony-stimulating factor levels and neutrophil counts in newborn infants.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 1995;17(2):176-9.
1995: McLeod H L; Relling M V; Liu Q; Pui C H; Evans W E
Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia.
Blood 1995;85(7):1897-902.
1995: Krynetski E Y; Schuetz J D; Galpin A J; Pui C H; Relling M V; Evans W E
A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):949-53.
1995: Uckun F M; Evans W E; Forsyth C J; Waddick K G; Ahlgren L T; Chelstrom L M; Burkhardt A; Bolen J; Myers D E
Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases.
Science (New York, N.Y.) 1995;267(5199):886-91.
1994: Evans W E; Relling M V
Mercaptopurine vs thioguanine for the treatment of acute lymphoblastic leukemia.
Leukemia research 1994;18(11):811-4.
1994: Synold T W; Relling M V; Boyett J M; Rivera G K; Sandlund J T; Mahmoud H; Crist W M; Pui C H; Evans W E
Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia.
The Journal of clinical investigation 1994;94(5):1996-2001.
1994: Crom W R; de Graaf S S; Synold T; Uges D R; Bloemhof H; Rivera G; Christensen M L; Mahmoud H; Evans W E
Pharmacokinetics of vincristine in children and adolescents with acute lymphocytic leukemia.
The Journal of pediatrics 1994;125(4):642-9.
1994: McLeod H L; Fang L; Luo X; Scott E P; Evans W E
Ethnic differences in erythrocyte catechol-O-methyltransferase activity in black and white Americans.
The Journal of pharmacology and experimental therapeutics 1994;270(1):26-9.
1994: Barredo J C; Synold T W; Laver J; Relling M V; Pui C H; Priest D G; Evans W E
Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia.
Blood 1994;84(2):564-9.
1994: Evans W E
Optimizing individual drug dosages.
The Journal of pharmacy and pharmacology 1994;46 Suppl 1():451-5.
1994: McLeod H L; Lin J S; Scott E P; Pui C H; Evans W E
Thiopurine methyltransferase activity in American white subjects and black subjects.
Clinical pharmacology and therapeutics 1994;55(1):15-20.
1993: Evans W E
Alternative approaches for Phase I studies of anticancer drugs: a role for therapeutic drug monitoring.
Therapeutic drug monitoring 1993;15(6):492-7.
1993: Galpin A J; Evans W E
Therapeutic drug monitoring in cancer management.
Clinical chemistry 1993;39(11 Pt 2):2419-30.
1993: Kearns C M; Wang W C; Stute N; Ihle J N; Evans W E
Disposition of recombinant human granulocyte colony-stimulating factor in children with severe chronic neutropenia.
The Journal of pediatrics 1993;123(3):471-9.
1993: Evans W E; Relling M V; Rahman A; McLeod H L; Scott E P; Lin J S
Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans.
The Journal of clinical investigation 1993;91(5):2150-4.
1993: Campana D; Manabe A; Evans W E
Stroma-supported immunocytometric assay (SIA): a novel method for testing the sensitivity of acute lymphoblastic leukemia cells to cytotoxic drugs.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(3):482-8.
1993: Rodman J H; Relling M V; Stewart C F; Synold T W; McLeod H; Kearns C; Stute N; Crom W R; Evans W E
Clinical pharmacokinetics and pharmacodynamics of anticancer drugs in children.
Seminars in oncology 1993;20(1):18-29.
1993: Rodman J H; Furman W L; Sunderland M; Rivera G; Evans W E
Escalating teniposide systemic exposure to increase dose intensity for pediatric cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(2):287-93.
1993: McLeod H L; Evans W E
Clinical pharmacokinetics and pharmacodynamics of epipodophyllotoxins.
Cancer surveys 1993;17():253-68.
1992: Relling M V; Lin J S; Ayers G D; Evans W E
Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities.
Clinical pharmacology and therapeutics 1992;52(6):643-58.
1992: McLeod H L; Evans W E
Pediatric pharmacokinetics and therapeutic drug monitoring.
Pediatrics in review / American Academy of Pediatrics 1992;13(11):413-21.
1992: Stute N; Santana V M; Rodman J H; Schell M J; Ihle J N; Evans W E
Pharmacokinetics of subcutaneous recombinant human granulocyte colony-stimulating factor in children.
Blood 1992;79(11):2849-54.
1992: Rivera G K; Evans W E
Clinical trials of teniposide (VM-26) in childhood acute lymphocytic leukemia.
Seminars in oncology 1992;19(2 Suppl 6):51-8.
1992: Fleming R A; Evans W E; Arbuck S G; Stewart C F
Factors affecting in vitro protein binding of etoposide in humans.
Journal of pharmaceutical sciences 1992;81(3):259-64.
1992: Baker D K; Relling M V; Pui C H; Christensen M L; Evans W E; Rodman J H
Increased teniposide clearance with concomitant anticonvulsant therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1992;10(2):311-5.
1992: Pui C H; Simone J V; Hancock M L; Evans W E; Williams D L; Bowman W P; Dahl G V; Dodge R K; Ochs J; Abromowitch M
Impact of three methods of treatment intensification on acute lymphoblastic leukemia in children: long-term results of St Jude total therapy study X.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1992;6(2):150-7.
1992: Evans W E; Rodman J H; Relling M V; Petros W P; Stewart C F; Pui C H; Rivera G K
Differences in teniposide disposition and pharmacodynamics in patients with newly diagnosed and relapsed acute lymphocytic leukemia.
The Journal of pharmacology and experimental therapeutics 1992;260(1):71-7.
1992: Petros W P; Rodman J H; Relling M V; Christensen M; Pui C H; Rivera G K; Evans W E
Variability in teniposide plasma protein binding is correlated with serum albumin concentrations.
Pharmacotherapy 1992;12(4):273-7.
1991: Evans W E; Horner M; Chu Y Q; Kalwinsky D; Roberts W M
Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia.
The Journal of pediatrics 1991;119(6):985-9.
1991: Pui C H; Ribeiro R C; Hancock M L; Rivera G K; Evans W E; Raimondi S C; Head D R; Behm F G; Mahmoud M H; Sandlund J T
Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia.
The New England journal of medicine 1991;325(24):1682-7.
1991: Stewart C F; Fleming R A; Germain B F; Seleznick M J; Evans W E
Aspirin alters methotrexate disposition in rheumatoid arthritis patients.
Arthritis and rheumatism 1991;34(12):1514-20.
1991: Evans W E; Relling M V
Concordance of P450 2D6 (debrisoquine hydroxylase) phenotype and genotype: inability of dextromethorphan metabolic ratio to discriminate reliably heterozygous and homozygous extensive metabolizers.
Pharmacogenetics 1991;1(3):143-8.
1991: Stewart C F; Arbuck S G; Fleming R A; Evans W E
Relation of systemic exposure to unbound etoposide and hematologic toxicity.
Clinical pharmacology and therapeutics 1991;50(4):385-93.
1991: Relling M V; Cherrie J; Schell M J; Petros W P; Meyer W H; Evans W E
Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects.
Clinical pharmacology and therapeutics 1991;50(3):308-13.
1991: Pui C H; Dodge R K; Look A T; George S L; Rivera G K; Abromowitch M; Ochs J; Evans W E; Crist W M; Simone J V
Risk of adverse events in children completing treatment for acute lymphoblastic leukemia: St. Jude Total Therapy studies VIII, IX, and X.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1991;9(8):1341-7.
1991: Crom W R; Relling M V; Christensen M L; Rivera G K; Evans W E
Age-related differences in hepatic drug clearance in children: studies with lorazepam and antipyrine.
Clinical pharmacology and therapeutics 1991;50(2):132-40.
1991: Furman W L; Fairclough D L; Huhn R D; Pratt C B; Stute N; Petros W P; Evans W E; Bowman L C; Douglass E C; Santana V M
Therapeutic effects and pharmacokinetics of recombinant human granulocyte-macrophage colony-stimulating factor in childhood cancer patients receiving myelosuppressive chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1991;9(6):1022-8.
1991: Evans W E; Rodman J H; Relling M V; Crom W R; Rivera G K; Pratt C B; Crist W M
Concept of maximum tolerated systemic exposure and its application to phase I-II studies of anticancer drugs.
Medical and pediatric oncology 1991;19(3):153-9.
1991: Petros W P; Rodman J H; Mirro J; Evans W E
Pharmacokinetics of continuous-infusion amsacrine and teniposide for the treatment of relapsed childhood acute nonlymphocytic leukemia.
Cancer chemotherapy and pharmacology 1991;27(5):397-400.
1990: Phelps S J; Evans W E; Chesney R W
Advances in pediatric pharmacokinetics and therapeutics.
The Journal of pediatrics 1990;117(6):996-1001.
1990: Stewart C F; Arbuck S G; Fleming R A; Evans W E
Changes in the clearance of total and unbound etoposide in patients with liver dysfunction.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990;8(11):1874-9.
1990: Stewart C F; Fleming R A; Arbuck S G; Evans W E
Prospective evaluation of a model for predicting etoposide plasma protein binding in cancer patients.
Cancer research 1990;50(21):6854-6.
1990: Rodman J H; Sunderland M; Kavanagh R L; Ochs J; Yalowich J; Evans W E; Rivera G K
Pharmacokinetics of continuous infusion of methotrexate and teniposide in pediatric cancer patients.
Cancer research 1990;50(14):4267-71.
1990: Evans W E; Relling M V
Xbal 16- plus 9-kilobase DNA restriction fragments identify a mutant allele for debrisoquin hydroxylase: report of a family study.
Molecular pharmacology 1990;37(5):639-42.
1990: Stewart C F; Fleming R A; Arkin C R; Evans W E
Coadministration of naproxen and low-dose methotrexate in patients with rheumatoid arthritis.
Clinical pharmacology and therapeutics 1990;47(4):540-6.
1990: Petros W P; Evans W E
Pharmacokinetics and pharmacodynamics of anticancer agents: contributions to the therapy of childhood cancer.
Pharmacotherapy 1990;10(5):313-25.
1989: Evans W E; Petros W P; Relling M V; Crom W R; Madden T; Rodman J H; Sunderland M
Clinical pharmacology of cancer chemotherapy in children.
Pediatric clinics of North America 1989;36(5):1199-230.
1989: de Graaf S S; Riley-Stewart C A; Evans W E
Improved high-performance liquid chromatographic method using loop-column extraction for analysis of idarubicin and idarubicinol in plasma.
Journal of chromatography 1989;491(2):501-6.
1989: Evans W E; Relling M V; de Graaf S; Rodman J H; Pieper J A; Christensen M L; Crom W R
Hepatic drug clearance in children: studies with indocyanine green as a model substrate.
Journal of pharmaceutical sciences 1989;78(6):452-6.
1989: Evans W E; Relling M V; Petros W P; Meyer W H; Mirro J; Crom W R
Dextromethorphan and caffeine as probes for simultaneous determination of debrisoquin-oxidation and N-acetylation phenotypes in children.
Clinical pharmacology and therapeutics 1989;45(5):568-73.
1989: Relling M V; Mulhern R K; Dodge R K; Johnson D; Pieper J A; Rivera G K; Evans W E
Lorazepam pharmacodynamics and pharmacokinetics in children.
The Journal of pediatrics 1989;114(4 Pt 1):641-6.
1989: Stewart C F; Pieper J A; Arbuck S G; Evans W E
Altered protein binding of etoposide in patients with cancer.
Clinical pharmacology and therapeutics 1989;45(1):49-55.
1989: Evans W E
Who said practice makes perfect?
Pharmacotherapy 1989;9(2):113-4.
1988: Relling M V; Stapleton F B; Ochs J; Jones D P; Meyer W; Wainer I W; Crom W R; McKay C P; Evans W E
Removal of methotrexate, leucovorin, and their metabolites by combined hemodialysis and hemoperfusion.
Cancer 1988;62(5):884-8.
1988: Pui C H; de Graaf S S; Dow L W; Rodman J H; Evans W E; Alpert B S; Murphy S B
Phase I clinical trial of orally administered 4-demethoxydaunorubicin (idarubicin) with pharmacokinetic and in vitro drug sensitivity testing in children with refractory leukemia.
Cancer research 1988;48(18):5348-52.
1988: Christensen M L; Rivera G K; Crom W R; Hancock M L; Evans W E
Effect of hydration on methotrexate plasma concentrations in children with acute lymphocytic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1988;6(5):797-801.
1988: Abromowitch M; Ochs J; Pui C H; Kalwinsky D; Rivera G K; Fairclough D; Look A T; Hustu H O; Murphy S B; Evans W E
High-dose methotrexate improves clinical outcome in children with acute lymphoblastic leukemia: St. Jude Total Therapy Study X.
Medical and pediatric oncology 1988;16(5):297-303.
1987: Stewart C F; Christensen M L; Evens R P; Cremer M; Evans W E
Influence of concomitant aspirin or prednisone on methotrexate synovial fluid concentration.
The Journal of pharmacology and experimental therapeutics 1987;243(1):131-7.
1987: Garré M L; Relling M V; Kalwinsky D; Dodge R; Crom W R; Abromowitch M; Pui C H; Evans W E
Pharmacokinetics and toxicity of methotrexate in children with Down syndrome and acute lymphocytic leukemia.
The Journal of pediatrics 1987;111(4):606-12.
1987: Evans W E; Abromowitch M; Crom W R; Relling M V; Bowman W P; Pui C H; Ochs J; Dodge R
Clinical pharmacodynamic studies of high-dose methotrexate in acute lymphocytic leukemia.
NCI monographs : a publication of the National Cancer Institute 1987;(5):81-5.
1986: Crom W R; Glynn A M; Abromowitch M; Pui C H; Dodge R; Evans W E
Use of the automatic interaction detector method to identify patient characteristics related to methotrexate clearance.
Clinical pharmacology and therapeutics 1986;39(5):592-7.
1986: Evans W E; Crom W R; Abromowitch M; Dodge R; Look A T; Bowman W P; George S L; Pui C H
Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect.
The New England journal of medicine 1986;314(8):471-7.
1985: Murphy S B; Dahl G V; Look A T; Ochs J; Abromowitch M; Pui C H; Bowman W P; Simone J V; Kalwinsky D K; Evans W E
Recent results from Total Therapy Study X for standard and high risk acute lymphoblastic leukemia in children: recognition of new clinical and biologic risk features.
Haematology and blood transfusion 1985;29():78-81.
1984: Evans W E; Crom W R; Stewart C F; Bowman W P; Chen C H; Abromowitch M; Simone J V
Methotrexate systemic clearance influences probability of relapse in children with standard-risk acute lymphocytic leukaemia.
Lancet 1984;1(8373):359-62.

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