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Mark Exley

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Shaoyong Li; Imad A Nasser; Yury Popov; Detlef Schuppan; Lianne E M Vriend; Nezam H Afdhal; Mark A Exley; Margaret J Koziel; Nadia Alatrakchi
Hepatitis C virus-specific T-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis.
Namita Rout; Simon Yue; David O'Connor; James ELSE; Mark A Exley; Justin Greene; R Paul Johnson; Amitinder Kaur
Loss of effector and anti-inflammatory natural killer T lymphocyte function in pathogenic simian immunodeficiency virus infection.
Mark A Exley; Lydia Lynch; Michael Nowak; Bindu Varghese; Nadia Alatrakchi; Steven P Balk
Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: reversing tumor-induced defects.

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All Publications

2012: Shaoyong Li; Imad A Nasser; Yury Popov; Detlef Schuppan; Lianne E M Vriend; Nezam H Afdhal; Mark A Exley; Margaret J Koziel; Nadia Alatrakchi
Hepatitis C virus-specific T-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis.
Hepatology (Baltimore, Md.) 2012;56(6):2094-105.
2012: Namita Rout; Simon Yue; David O'Connor; James ELSE; Mark A Exley; Justin Greene; R Paul Johnson; Amitinder Kaur
Loss of effector and anti-inflammatory natural killer T lymphocyte function in pathogenic simian immunodeficiency virus infection.
PLoS pathogens 2012;8(9):e1002928.
2011: Mark A Exley; Lydia Lynch; Michael Nowak; Bindu Varghese; Nadia Alatrakchi; Steven P Balk
Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: reversing tumor-induced defects.
Clinical immunology (Orlando, Fla.) 2011;140(2):184-95.
2011: Mark A Exley; Toshinori Nakayama
NKT-cell-based immunotherapies in clinical trials.
Clinical immunology (Orlando, Fla.) 2011;140(2):117-8.
2011: W Song; Yu-Tzu Tai; Z Tian; Teru Hideshima; Dharminder Chauhan; P Nanjappa; Mark A Exley; Kenneth C Anderson; Nikhil C Munshi
HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells.
Leukemia 2011;25(1):161-8.
2010: Ralph Budd; Sally Huber; Mark A Exley
Comment on "Essential Role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung".
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):1991; author reply 1991-2.
2010: Mark A Exley; Brian Wilson; Steven P Balk
Isolation and functional use of human NKT cells.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2010;Chapter 14():Unit 14.11.
2010: Namita Rout; James ELSE; Simon Yue; Michelle Connole; Mark A Exley; Amitinder Kaur
Heterogeneity in phenotype and function of CD8+ and CD4/CD8 double-negative Natural Killer T cell subsets in sooty mangabeys.
Journal of medical primatology 2010;39(4):224-34.
2010: Namita Rout; James ELSE; Simon Yue; Michelle Connole; Mark A Exley; Amitinder Kaur
Paucity of CD4+ natural killer T (NKT) lymphocytes in sooty mangabeys is associated with lack of NKT cell depletion after SIV infection.
PloS one 2010;5(3):e9787.
2010: Simon C Yue; Michael Nowak; Angela Shaulov-Kask; RuoJie Wang; Dominic Yue; Steven P Balk; Mark A Exley
Direct CD1d-mediated stimulation of APC IL-12 production and protective immune response to virus infection in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(1):268-76.
2008: Mark A Exley; Runhua Hou; Angela Shaulov; Elena Tonti; Paolo Dellabona; Giulia Casorati; Omid Akbari; H Orhan Akman; Edward Greenfield; Jenny E Gumperz; Jonathan Boyson; Steven P Balk; S Brian Wilson
Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop.
European journal of immunology 2008;38(6):1756-66.
2008: Hans J J van der Vliet; Ruojie Wang; Simon C Yue; Henry B Koon; Steven P Balk; Mark A Exley
Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7287-93.
2008: Angela Shaulov; Simon Yue; Ruojie Wang; Robin M Joyce; Steven P Balk; Haesook T Kim; David Avigan; Lynne Uhl; Robert Sackstein; Mark A Exley
Peripheral blood progenitor cell product contains Th1-biased noninvariant CD1d-reactive natural killer T cells: implications for posttransplant survival.
Experimental hematology 2008;36(4):464-72.
2008: Balgansuren Gansuvd; Jeanine Goodwin; Clement K Asiedu; Xiao Ling Jiang; Uuganbayar Jargal; Patricio Andrades; Mark A Exley; Judith M Thomas
Invariant natural killer T cells from rhesus macaque spleen and peripheral blood are phenotypically and functionally distinct populations.
Journal of medical primatology 2008;37(1):1-11.
2007: Hans J J van der Vliet; Henry B Koon; Michael B Atkins; Steven P Balk; Mark A Exley
Exploiting regulatory T-cell populations for the immunotherapy of cancer.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2007;30(6):591-5.
2007: Nadia Alatrakchi; Camilla S Graham; Hans J J van der Vliet; Kenneth E Sherman; Mark A Exley; Margaret James Koziel
Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses.
Journal of virology 2007;81(11):5882-92.
2007: Hans J J van der Vliet; Hans J J van der Vliet; Henry B Koon; Simon C Yue; Burak Uzunparmak; Virginia Seery; Marc A Gavin; Alexander Y Rudensky; Michael B Atkins; Steven P Balk; Mark A Exley
Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(7):2100-8.
2006: Hans J J van der Vliet; Steven P Balk; Mark A Exley
Natural killer T cell-based cancer immunotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(20 Pt 1):5921-3.
2006: Petr O Ilyinskii; Ruojie Wang; Steven P Balk; Mark A Exley
CD1d mediates T-cell-dependent resistance to secondary infection with encephalomyocarditis virus (EMCV) in vitro and immune response to EMCV infection in vivo.
Journal of virology 2006;80(14):7146-58.
2006: Jonathan Boyson; Nisha Nagarkatti; Leena Nizam; Mark A Exley; Jack L Strominger
Gestation stage-dependent mechanisms of invariant natural killer T cell-mediated pregnancy loss.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4580-5.
2005: Koh-Hei Sonoda; Taiji Sakamoto; Hong Qiao; Toshio Hisatomi; Toru Oshima; Chikako Tsutsumi-Miyahara; Mark A Exley; Steven P Balk; Masaru Taniguchi; Tatsuro Ishibashi
The analysis of systemic tolerance elicited by antigen inoculation into the vitreous cavity: vitreous cavity-associated immune deviation.
Immunology 2005;116(3):390-9.
2005: Simon C Yue; Angela Shaulov; Ruojie Wang; Steven P Balk; Mark A Exley
CD1d ligation on human monocytes directly signals rapid NF-kappaB activation and production of bioactive IL-12.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(33):11811-6.
2005: Stephanie K Dougan; Azucena Salas; Paul Rava; Amma Agyemang; Arthur Kaser; Jamin Morrison; Archana Khurana; Mitchell Kronenberg; Caroline Johnson; Mark A Exley; M Mahmood Hussain; Richard S Blumberg
Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells.
The Journal of experimental medicine 2005;202(4):529-39.
2005: Sungyoo Cho; Kenneth S Knox; Lisa M Kohli; Johnny J He; Mark A Exley; S Brian Wilson; Randy R Brutkiewicz
Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex.
Virology 2005;337(2):242-52.
2005: Edward E S Nieuwenhuis; Silke Gillessen; Rik J Scheper; Mark A Exley; Masaru Taniguchi; Steven P Balk; Jack L Strominger; Glenn Dranoff; Richard S Blumberg; S Brian Wilson
CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity.
Experimental dermatology 2005;14(4):250-8.
2004: Mark A Exley; Margaret James Koziel
To be or not to be NKT: natural killer T cells in the liver.
Hepatology (Baltimore, Md.) 2004;40(5):1033-40.
2004: Kenneth Christopher; Yurong Liang; Thomas F Mueller; Rachel Defina; Hongzhen He; Kathleen J Haley; Mark A Exley; Patricia W Finn; David L Perkins
Analysis of the major histocompatibility complex in graft rejection revisited by gene expression profiles.
Transplantation 2004;78(6):788-98.
2004: Emanuele Durante Mangoni; RuoJie Wang; Angela Shaulov; Qi He; Imad Nasser; Nezam H Afdhal; Margaret James Koziel; Mark A Exley
Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):2159-66.
2004: Suzana Brozovic; Takashi Nagaishi; Masaru Yoshida; Stephanie Betz; Azucena Salas; Daohong Chen; Arthur Kaser; Jonathan N Glickman; Timothy Kuo; Alicia Little; Jamin Morrison; Nadia Corazza; Jin Yong Kim; Sean P Colgan; Stephen G Young; Mark A Exley; Richard S Blumberg
CD1d function is regulated by microsomal triglyceride transfer protein.
Nature medicine 2004;10(5):535-9.
2003: Mark A Exley; Nancy J Bigley; Olivia Cheng; Angela Shaulov; Syed Muhammad Ali Tahir; Quincy L Carter; Jorge Garcia; Carren Wang; Kurt Patten; Harold F Stills; Frederick W Alt; Scott B Snapper; Steven P Balk
Innate immune response to encephalomyocarditis virus infection mediated by CD1d.
Immunology 2003;110(4):519-26.
2003: Ofer Levy; Jordan S Orange; Patricia Hibberd; Sharon Steinberg; Philip S LaRussa; Adriana Weinberg; S Brian Wilson; Angela Shaulov; Gary Fleisher; Raif S Geha; Francisco A Bonilla; Mark A Exley
Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells.
The Journal of infectious diseases 2003;188(7):948-53.
2003: Balgansuren Gansuvd; William J Hubbard; Anne Hutchings; Francis T Thomas; Jeanine Goodwin; S Brian Wilson; Mark A Exley; Judith M Thomas
Phenotypic and functional characterization of long-term cultured rhesus macaque spleen-derived NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):2904-11.
2003: Silke Gillessen; Yuri N Naumov; Edward E S Nieuwenhuis; Mark A Exley; Frederick S Lee; Nicolas Mach; Andrew D Luster; Richard S Blumberg; Masaru Taniguchi; Steven P Balk; Jack L Strominger; Glenn Dranoff; S Brian Wilson
CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte-macrophage colony-stimulating factor-dependent fashion.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8874-9.
2003: Sally Huber; Danielle Sartini; Mark A Exley
Role of CD1d in coxsackievirus B3-induced myocarditis.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3147-53.
2002: Sally A Huber; Danielle Sartini; Mark A Exley
Vgamma4(+) T cells promote autoimmune CD8(+) cytolytic T-lymphocyte activation in coxsackievirus B3-induced myocarditis in mice: role for CD4(+) Th1 cells.
Journal of virology 2002;76(21):10785-90.
2002: Jonathan Boyson; Basya Rybalov; Louise A Koopman; Mark A Exley; Steven P Balk; Frederick K Racke; Frederick Schatz; Rachel J. Masch; S Brian Wilson; Jack L Strominger
CD1d and invariant NKT cells at the human maternal-fetal interface.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13741-6.
2002: Edward E S Nieuwenhuis; Tetsuya Matsumoto; Mark A Exley; Robbert A Schleipman; Jonathan N Glickman; Dan T Bailey; Nadia Corazza; Sean P Colgan; Andrew B Onderdonk; Richard S Blumberg
CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung.
Nature medicine 2002;8(6):588-93.
2002: Mark A Exley; Qi He; Olivia Cheng; Ruo-jie Wang; Catherine P Cheney; Steven P Balk; Margaret James Koziel
Cutting edge: Compartmentalization of Th1-like noninvariant CD1d-reactive T cells in hepatitis C virus-infected liver.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1519-23.
2002: Anjli Kukreja; Giulia Cost; John Marker; Chenhui Zhang; Zhong Sun; Karen Lin-Su; Svetlana Ten; Maureen Sanz; Mark A Exley; Brian Wilson; Steven A Porcelli; Noel Maclaren
Multiple immuno-regulatory defects in type-1 diabetes.
The Journal of clinical investigation 2002;109(1):131-40.
2001: Y N Naumov; Keith Bahjat; R Gausling; R Abraham; Mark A Exley; Yasuhiko Koezuka; S B Balk; Jack L Strominger; M Clare-Salzer; S Brian Wilson
Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13838-43.
2001: Mark A Exley; Syed Muhammad Ali Tahir; Olivia Cheng; Angela Shaulov; Robin M Joyce; David Avigan; R Sackstein; Steven P Balk
A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5531-4.
2001: Syed Muhammad Ali Tahir; Olivia Cheng; Angela Shaulov; Yasuhiko Koezuka; G J Bubley; S Brian Wilson; Steven P Balk; Mark A Exley
Loss of IFN-gamma production by invariant NK T cells in advanced cancer.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(7):4046-50.
2001: C Stremmel; Mark A Exley; Steven P Balk; W Hohenberger; Vijay K Kuchroo
Characterization of the phenotype and function of CD8(+), alpha / beta(+) NKT cells from tumor-bearing mice that show a natural killer cell activity and lyse multiple tumor targets.
European journal of immunology 2001;31(9):2818-28.
2001: Mark A Exley; N J Bigley; Olivia Cheng; Syed Muhammad Ali Tahir; ST Smiley; Quincy L Carter; Harold F Stills; Michael J Grusby; Yasuhiko Koezuka; M Taniguchi; Steven P Balk
CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus.
Journal of leukocyte biology 2001;69(5):713-8.
2001: T Dao; Mark A Exley; Wajahat Z Mehal; Syed Muhammad Ali Tahir; Scott B Snapper; M Taniguchi; Steven P Balk; I Nicholas Crispe
Involvement of CD1 in peripheral deletion of T lymphocytes is independent of NK T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3090-7.
2001: Koh-Hei Sonoda; Douglas E Faunce; M Taniguchi; Mark A Exley; Steven P Balk; Joan Stein-Streilein
NK T cell-derived IL-10 is essential for the differentiation of antigen-specific T regulatory cells in systemic tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):42-50.
2000: Lawrence J Saubermann; P Beck; Ype P de Jong; Richard S Pitman; M S Ryan; H S Kim; Mark A Exley; Scott B Snapper; Steven P Balk; S J Hagen; O Kanauchi; Kazuhiro Motoki; T Sakai; Cox Terhorst; Yasuhiko Koezuka; Daniel K Podolsky; Richard S Blumberg
Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice.
Gastroenterology 2000;119(1):119-28.
2000: Mark A Exley; J Garcia; S Brian Wilson; F Spada; D Gerdes; Syed Muhammad Ali Tahir; K T Patton; R S Blumberg; Steven A Porcelli; A Chott; Steven P Balk
CD1d structure and regulation on human thymocytes, peripheral blood T cells, B cells and monocytes.
Immunology 2000;100(1):37-47.
1999: Koh-Hei Sonoda; Mark A Exley; Scott B Snapper; Steven P Balk; Joan Stein-Streilein
CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site.
The Journal of experimental medicine 1999;190(9):1215-26.
1998: Mark A Exley; Steven A Porcelli; M Furman; J Garcia; Steven P Balk
CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant V alpha 24 J alpha Q T cell receptor alpha chains.
The Journal of experimental medicine 1998;188(5):867-76.
1998: S Brian Wilson; Sally C Kent; K T Patton; Tihamer Orban; Rebecca A Jackson; Mark A Exley; Steven A Porcelli; Desmond A Schatz; M A Atkinson; Steven P Balk; Jack L Strominger; David A Hafler
Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes.
Nature 1998;391(6663):177-81.
1997: Mark A Exley; J Garcia; Steven P Balk; Steven A Porcelli
Requirements for CD1d recognition by human invariant Valpha24+ CD4-CD8- T cells.
The Journal of experimental medicine 1997;186(1):109-20.
1997: Mark A Exley; L Varticovski
Evidence for phosphatidylinositol 3-kinase-dependent T cell antigen receptor (TCR) signal transduction.
Molecular immunology 1997;34(3):221-6.
1995: Mark A Exley; T Wileman; B Mueller; Cox Terhorst
Evidence for multivalent structure of T-cell antigen receptor complex.
Molecular immunology 1995;32(11):829-39.
1994: Mark A Exley; L Varticovski; M Peter; Jaime Sancho; Cox Terhorst
Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation.
The Journal of biological chemistry 1994;269(21):15140-6.
1993: J Young; L P Kane; Mark A Exley; T Wileman
Regulation of selective protein degradation in the endoplasmic reticulum by redox potential.
The Journal of biological chemistry 1993;268(26):19810-8.
1993: Cox Terhorst; Mark A Exley; R Franco; C Hall; J Kang; B Mueller; Jaime Sancho; J She; T Wileman
Coupling of T-cell activation with T-cell receptor assembly.
The Year in immunology 1993;7():1-24.
1991: Mark A Exley; Cox Terhorst; T Wileman
Structure, assembly and intracellular transport of the T cell receptor for antigen.
Seminars in immunology 1991;3(5):283-97.