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John Exton

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TOP 3
John H Exton
In search of the message.
H Alex Brown; Lee G Henage; Anita M Preininger; Yun Xiang; John H Exton
Biochemical analysis of phospholipase D.
Anthony D Couvillon; John H Exton
Role of heterotrimeric G-proteins in lysophosphatidic acid-mediated neurite retraction by RhoA-dependent and -independent mechanisms in N1E-115 cells.

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All Publications

2008: John H Exton
In search of the message.
The Journal of biological chemistry 2008;283(22):14901-9.
2007: H Alex Brown; Lee G Henage; Anita M Preininger; Yun Xiang; John H Exton
Biochemical analysis of phospholipase D.
Methods in enzymology 2007;434():49-87.
2006: Anthony D Couvillon; John H Exton
Role of heterotrimeric G-proteins in lysophosphatidic acid-mediated neurite retraction by RhoA-dependent and -independent mechanisms in N1E-115 cells.
Cellular signalling 2006;18(5):715-28.
2006: Ping Hu; Zhang Han; Anthony D Couvillon; Randal J Kaufman; John H Exton
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression.
Molecular and cellular biology 2006;26(8):3071-84.
2006: Lee G Henage; John H Exton; H Alex Brown
Kinetic analysis of a mammalian phospholipase D: allosteric modulation by monomeric GTPases, protein kinase C, and polyphosphoinositides.
The Journal of biological chemistry 2006;281(6):3408-17.
2005: Seunghyi Kook; John H Exton
Identification of interaction sites of protein kinase Calpha on phospholipase D1.
Cellular signalling 2005;17(11):1423-32.
2005: Jun-Song Chen; John H Exton
Sites on phospholipase D2 phosphorylated by PKCalpha.
Biochemical and biophysical research communications 2005;333(4):1322-6.
2005: Tianhui Hu; John H Exton
A point mutation at phenylalanine 663 abolishes protein kinase C alpha's ability to translocate to the perinuclear region and activate phospholipase D1.
Biochemical and biophysical research communications 2005;333(3):750-3.
2005: Wan-Ting Ho; Zhi Xie; Zhizhuang Joe Zhao; John H Exton
Tyrosine phosphorylation of phospholipase D1 by v-Src does not per se result in activation.
Cellular signalling 2005;17(6):691-9.
2005: Masami Hiroyama; John H Exton
Localization and regulation of phospholipase D2 by ARF6.
Journal of cellular biochemistry 2005;95(1):149-64.
2005: Tianhui Hu; John H Exton
1-Butanol interferes with phospholipase D1 and protein kinase Calpha association and inhibits phospholipase D1 basal activity.
Biochemical and biophysical research communications 2005;327(4):1047-51.
2005: F Gregory Buchanan; Matt McReynolds; Anthony D Couvillon; Yoonseok Kam; Vijaykumar R Holla; Raymond DuBois; John H Exton
Requirement of phospholipase D1 activity in H-RasV12-induced transformation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1638-42.
2005: Masami Hiroyama; John H Exton
Studies of the roles of ADP-ribosylation factors and phospholipase D in phorbol ester-induced membrane ruffling.
Journal of cellular physiology 2005;202(2):608-22.
2005: Ok-Ho Shin; John H Exton
Assays and properties of arfaptin 2 binding to Rac1 and ADP-ribosylation factors (Arfs).
Methods in enzymology 2005;404():359-67.
2004: Ping Hu; Zhang Han; Anthony D Couvillon; John H Exton
Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death.
The Journal of biological chemistry 2004;279(47):49420-9.
2004: Tianhui Hu; John H Exton
Protein kinase Calpha translocates to the perinuclear region to activate phospholipase D1.
The Journal of biological chemistry 2004;279(34):35702-8.
2004: Jun-Song Chen; John H Exton
Regulation of phospholipase D2 activity by protein kinase C alpha.
The Journal of biological chemistry 2004;279(21):22076-83.
2004: Yoonseok Kam; John H Exton
Role of phospholipase D in the activation of protein kinase D by lysophosphatidic acid.
Biochemical and biophysical research communications 2004;315(1):139-43.
2004: Yoonseok Kam; John H Exton
Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):311-9.
2003: Wan-Ting Ho; John H Exton; Ben-Tsion Williger
Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in HT 1080 fibrosarcoma cells.
FEBS letters 2003;537(1-3):91-5.
2003: Tianhui Hu; John H Exton
Mechanisms of regulation of phospholipase D1 by protein kinase Calpha.
The Journal of biological chemistry 2003;278(4):2348-55.
2002: John H Exton
Regulation of phospholipase D.
FEBS letters 2002;531(1):58-61.
2002: Zhi Xie; Wan-Ting Ho; Rachel Spellman; Songmin Cai; John H Exton
Mechanisms of regulation of phospholipase D1 and D2 by the heterotrimeric G proteins G13 and Gq.
The Journal of biological chemistry 2002;277(14):11979-86.
2002: Zhi Xie; Wan-Ting Ho; John H Exton
Functional implications of post-translational modifications of phospholipases D1 and D2.
Biochimica et biophysica acta 2002;1580(1):9-21.
2002: Yoonseok Kam; John H Exton
Dimerization of phospholipase d isozymes.
Biochemical and biophysical research communications 2002;290(1):375-80.
2002: John H Exton
Phospholipase D-structure, regulation and function.
Reviews of physiology, biochemistry and pharmacology 2002;144():1-94.
2002: Zhi Xie; Ha-Kun Kim; John H Exton
Expression and characterization of rat brain phospholipase D.
Methods in enzymology 2002;345():255-64.
2001: Ok-Ho Shin; Anthony D Couvillon; John H Exton
Arfophilin is a common target of both class II and class III ADP-ribosylation factors.
Biochemistry 2001;40(36):10846-52.
2001: Ok-Ho Shin; John H Exton
Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1.
Biochemical and biophysical research communications 2001;285(5):1267-73.
2001: Yoonseok Kam; John H Exton
Phospholipase D activity is required for actin stress fiber formation in fibroblasts.
Molecular and cellular biology 2001;21(12):4055-66.
2001: Songmin Cai; John H Exton
Determination of interaction sites of phospholipase D1 for RhoA.
The Biochemical journal 2001;355(Pt 3):779-85.
2001: Zhi Xie; Wan-Ting Ho; John H Exton
Requirements and effects of palmitoylation of rat PLD1.
The Journal of biological chemistry 2001;276(12):9383-91.
2000: Zhi Xie; Wan-Ting Ho; John H Exton
Conserved amino acids at the C-terminus of rat phospholipase D1 are essential for enzymatic activity.
European journal of biochemistry / FEBS 2000;267(24):7138-46.
2000: S Jin; John H Exton
Activation of RhoA by association of Galpha(13) with Dbl.
Biochemical and biophysical research communications 2000;277(3):718-21.
2000: Zhi Xie; Wan-Ting Ho; John H Exton
Association of the N- and C-terminal domains of phospholipase D. Contribution of the conserved HKD motifs to the interaction and the requirement of the association for Ser/Thr phosphorylation of the enzyme.
The Journal of biological chemistry 2000;275(32):24962-9.
2000: John H Exton
Phospholipase D.
Annals of the New York Academy of Sciences 2000;905():61-8.
2000: F Gregory Buchanan; C M Elliot; M Gibbs; John H Exton
Translocation of the Rac1 guanine nucleotide exchange factor Tiam1 induced by platelet-derived growth factor and lysophosphatidic acid.
The Journal of biological chemistry 2000;275(13):9742-8.
2000: JA Hess; F Gregory Buchanan; S Ryder; John H Exton
Altered activation of phospholipase D by lysophosphatidic acid and endothelin-1 in mouse embryo fibroblasts lacking phospholipase C-gamma1.
Cellular signalling 2000;12(1):37-45.
1999: Ok-Ho Shin; A H Ross; I Mihai; John H Exton
Identification of arfophilin, a target protein for GTP-bound class II ADP-ribosylation factors.
The Journal of biological chemistry 1999;274(51):36609-15.
1999: John H Exton
Regulation of phospholipase D.
Biochimica et biophysica acta 1999;1439(2):121-33.
1999: Ben-Tsion Williger; JJ Provost; Wan-Ting Ho; J Milstine; John H Exton
Arfaptin 1 forms a complex with ADP-ribosylation factor and inhibits phospholipase D.
FEBS letters 1999;454(1-2):85-9.
1999: Ian N Fleming; CM Elliott; F Gregory Buchanan; C Peter Downes; John H Exton
Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation.
The Journal of biological chemistry 1999;274(18):12753-8.
1999: Ben-Tsion Williger; J Ostermann; John H Exton
Arfaptin 1, an ARF-binding protein, inhibits phospholipase D and endoplasmic reticulum/Golgi protein transport.
FEBS letters 1999;443(2):197-200.
1999: Ben-Tsion Williger; Wan-Ting Ho; John H Exton
Phospholipase D mediates matrix metalloproteinase-9 secretion in phorbol ester-stimulated human fibrosarcoma cells.
The Journal of biological chemistry 1999;274(2):735-8.
1998: Zhi Xie; Wan-Ting Ho; John H Exton
Association of N- and C-terminal domains of phospholipase D is required for catalytic activity.
The Journal of biological chemistry 1998;273(52):34679-82.
1998: John H Exton
Phospholipase D.
Biochimica et biophysica acta 1998;1436(1-2):105-15.
1998: DS Min; E G Kim; John H Exton
Involvement of tyrosine phosphorylation and protein kinase C in the activation of phospholipase D by H2O2 in Swiss 3T3 fibroblasts.
The Journal of biological chemistry 1998;273(45):29986-94.
1998: I Guillemain; John H Exton
Role of rho proteins in agonist regulation of phospholipase D in HL-60 cells.
Biochimica et biophysica acta 1998;1405(1-3):161-70.
1998: JA Hess; QS Ji; Graham Carpenter; John H Exton
Analysis of platelet-derived growth factor-induced phospholipase D activation in mouse embryo fibroblasts lacking phospholipase C-gamma1.
The Journal of biological chemistry 1998;273(32):20517-24.
1998: John H Exton
Small GTPases minireview series.
The Journal of biological chemistry 1998;273(32):19923.
1998: DS Min; John H Exton
Phospholipase D is associated in a phorbol ester-dependent manner with protein kinase C-alpha and with a 220-kDa protein which is phosphorylated on serine and threonine.
Biochemical and biophysical research communications 1998;248(3):533-7.
1998: Ian N Fleming; CM Elliott; John H Exton
Phospholipase C-gamma, protein kinase C and Ca2+/calmodulin-dependent protein kinase II are involved in platelet-derived growth factor-induced phosphorylation of Tiam1.
FEBS letters 1998;429(3):229-33.
1998: C D Bae; DS Min; Ian N Fleming; John H Exton
Determination of interaction sites on the small G protein RhoA for phospholipase D.
The Journal of biological chemistry 1998;273(19):11596-604.
1998: DS Min; SK Park; John H Exton
Characterization of a rat brain phospholipase D isozyme.
The Journal of biological chemistry 1998;273(12):7044-51.
1998: SK Park; DS Min; John H Exton
Definition of the protein kinase C interaction site of phospholipase D.
Biochemical and biophysical research communications 1998;244(2):364-7.
1998: S G Plonk; SK Park; John H Exton
The alpha-subunit of the heterotrimeric G protein G13 activates a phospholipase D isozyme by a pathway requiring Rho family GTPases.
The Journal of biological chemistry 1998;273(9):4823-6.
1997: Ian N Fleming; CM Elliott; J G Collard; John H Exton
Lysophosphatidic acid induces threonine phosphorylation of Tiam1 in Swiss 3T3 fibroblasts via activation of protein kinase C.
The Journal of biological chemistry 1997;272(52):33105-10.
1997: SK Park; JJ Provost; C D Bae; Wan-Ting Ho; John H Exton
Cloning and characterization of phospholipase D from rat brain.
The Journal of biological chemistry 1997;272(46):29263-71.
1997: I Guillemain; John H Exton
Effects of brefeldin A on phosphatidylcholine phospholipase D and inositolphospholipid metabolism in HL-60 cells.
European journal of biochemistry / FEBS 1997;249(3):812-9.
1997: John H Exton
New developments in phospholipase D.
The Journal of biological chemistry 1997;272(25):15579-82.
1997: E J Yeo; JJ Provost; John H Exton
Dissociation of tyrosine phosphorylation and activation of phosphoinositide phospholipase C induced by the protein kinase C inhibitor Ro-31-8220 in Swiss 3T3 cells treated with platelet-derived growth factor.
Biochimica et biophysica acta 1997;1356(3):308-20.
1997: John H Exton
Phospholipase D: enzymology, mechanisms of regulation, and function.
Physiological reviews 1997;77(2):303-20.
1997: H Kanoh; Ben-Tsion Williger; John H Exton
Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes.
The Journal of biological chemistry 1997;272(9):5421-9.
1997: AM Vinggaard; JJ Provost; John H Exton; Harald Hansen
Arf and RhoA regulate both the cytosolic and the membrane-bound phospholipase D from human placenta.
Cellular signalling 1997;9(2):189-96.
1997: JA Hess; A H Ross; R G Qiu; Marc Symons; John H Exton
Role of Rho family proteins in phospholipase D activation by growth factors.
The Journal of biological chemistry 1997;272(3):1615-20.
1997: John H Exton
Cell signalling through guanine-nucleotide-binding regulatory proteins (G proteins) and phospholipases.
European journal of biochemistry / FEBS 1997;243(1-2):10-20.
1997: John H Exton
Regulation of phosphoinositide phospholipases by G-proteins.
Advances in experimental medicine and biology 1997;400A():3-8.
1996: Ian N Fleming; C M Elliott; John H Exton
Differential translocation of rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor.
The Journal of biological chemistry 1996;271(51):33067-73.
1996: JJ Provost; J Fudge; S Israelit; A R Siddiqi; John H Exton
Tissue-specific distribution and subcellular distribution of phospholipase D in rat: evidence for distinct RhoA- and ADP-ribosylation factor (ARF)-regulated isoenzymes.
The Biochemical journal 1996;319 ( Pt 1)():285-91.
1996: K C Malcolm; C L Sable; C M Elliott; John H Exton
Enhanced phospholipase D activity and altered morphology in RhoA-overexpressing RAT1 fibroblasts.
Biochemical and biophysical research communications 1996;225(2):514-9.
1996: M J Pete; John H Exton
Purification of a lysophospholipase from bovine brain that selectively deacylates arachidonoyl-substituted lysophosphatidylcholine.
The Journal of biological chemistry 1996;271(30):18114-21.
1996: K C Malcolm; C M Elliott; John H Exton
Evidence for Rho-mediated agonist stimulation of phospholipase D in rat1 fibroblasts. Effects of Clostridium botulinum C3 exoenzyme.
The Journal of biological chemistry 1996;271(22):13135-9.
1996: G Venkatakrishnan; John H Exton
Identification of determinants in the alpha-subunit of Gq required for phospholipase C activation.
The Journal of biological chemistry 1996;271(9):5066-72.
1996: M J Pete; D W Wu; John H Exton
Subcellular fractions of bovine brain degrade phosphatidylcholine by sequential deacylation of the sn-1 and sn-2 positions.
Biochimica et biophysica acta 1996;1299(3):325-32.
1996: John H Exton
Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins.
Annual review of pharmacology and toxicology 1996;36():481-509.
1995: K C Malcolm; S E Trammell; John H Exton
Purinergic agonist and G protein stimulation of phospholipase D in rat liver plasma membranes. Independence from phospholipase C activation.
Biochimica et biophysica acta 1995;1268(2):152-8.
1995: M J Pete; John H Exton
Phospholipid interactions affect substrate hydrolysis by bovine brain phospholipase A1.
Biochimica et biophysica acta 1995;1256(3):367-73.
1995: A R Siddiqi; J L Smith; A H Ross; R G Qiu; Marc Symons; John H Exton
Regulation of phospholipase D in HL60 cells. Evidence for a cytosolic phospholipase D.
The Journal of biological chemistry 1995;270(15):8466-73.
1995: E J Yeo; John H Exton
Stimulation of phospholipase D by epidermal growth factor requires protein kinase C activation in Swiss 3T3 cells.
The Journal of biological chemistry 1995;270(8):3980-8.
1994: E J Yeo; Andrius Kazlauskas; John H Exton
Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor.
The Journal of biological chemistry 1994;269(45):27823-6.
1994: K C Malcolm; A H Ross; R G Qiu; Marc Symons; John H Exton
Activation of rat liver phospholipase D by the small GTP-binding protein RhoA.
The Journal of biological chemistry 1994;269(42):25951-4.
1994: K S Ha; E J Yeo; John H Exton
Lysophosphatidic acid activation of phosphatidylcholine-hydrolysing phospholipase D and actin polymerization by a pertussis toxin-sensitive mechanism.
The Biochemical journal 1994;303 ( Pt 1)():55-9.
1994: M J Pete; A H Ross; John H Exton
Purification and properties of phospholipase A1 from bovine brain.
The Journal of biological chemistry 1994;269(30):19494-500.
1994: John H Exton
Phosphatidylcholine breakdown and signal transduction.
Biochimica et biophysica acta 1994;1212(1):26-42.
1994: K M Conricode; J L Smith; D J Burns; John H Exton
Phospholipase D activation in fibroblast membranes by the alpha and beta isoforms of protein kinase C.
FEBS letters 1994;342(2):149-53.
1994: John H Exton
Messenger molecules derived from membrane lipids.
Current opinion in cell biology 1994;6(2):226-9.
1994: John H Exton
Phosphoinositide phospholipases and G proteins in hormone action.
Annual review of physiology 1994;56():349-69.
1993: K S Ha; John H Exton
Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts.
The Journal of cell biology 1993;123(6 Pt 2):1789-96.
1993: J L Blank; K Shaw; A H Ross; John H Exton
Purification of a 110-kDa phosphoinositide phospholipase C that is activated by G-protein beta gamma-subunits.
The Journal of biological chemistry 1993;268(33):25184-91.
1993: K S Ha; John H Exton
Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. A possible function for phosphatidylcholine-derived diacylglycerol.
The Journal of biological chemistry 1993;268(14):10534-9.
1993: C J Allan; John H Exton
Quantification of inositol phospholipid breakdown in isolated rat hepatocytes.
The Biochemical journal 1993;290 ( Pt 3)():865-72.
1993: H Nakanishi; K A Brewer; John H Exton
Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.
The Journal of biological chemistry 1993;268(1):13-6.
1993: John H Exton
Role of G proteins in activation of phosphoinositide phospholipase C.
Advances in second messenger and phosphoprotein research 1993;28():65-72.
1992: Rafat Siddiqui; John H Exton
Oleate stimulation of diacylglycerol formation from phosphatidylcholine through effects on phospholipase D and phosphatidate phosphohydrolase.
European journal of biochemistry / FEBS 1992;210(2):601-7.
1992: J L Blank; K A Brattain; John H Exton
Activation of cytosolic phosphoinositide phospholipase C by G-protein beta gamma subunits.
The Journal of biological chemistry 1992;267(32):23069-75.
1992: H Nakanishi; John H Exton
Purification and characterization of the zeta isoform of protein kinase C from bovine kidney.
The Journal of biological chemistry 1992;267(23):16347-54.
1992: G Berstein; J L Blank; D Y Jhon; John H Exton; S G Rhee; Elliott M Ross
Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator.
Cell 1992;70(3):411-8.
1992: K Shaw; John H Exton
Identification in bovine liver plasma membranes of a Gq-activatable phosphoinositide phospholipase C.
Biochemistry 1992;31(27):6347-54.
1992: G Berstein; J L Blank; A V Smrcka; T Higashijima; Paul C Sternweis; John H Exton; Elliott M Ross
Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1.
The Journal of biological chemistry 1992;267(12):8081-8.
1992: K M Conricode; K A Brewer; John H Exton
Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.
The Journal of biological chemistry 1992;267(11):7199-202.
1992: Rafat Siddiqui; John H Exton
Phospholipid base exchange activity in rat liver plasma membranes. Evidence for regulation by G-protein and P2y-purinergic receptor.
The Journal of biological chemistry 1992;267(9):5755-61.
1992: John H Exton; S J Taylor; J S Blank; S B Bocckino
Regulation of phosphoinositide and phosphatidylcholine phospholipases by G proteins.
Ciba Foundation symposium 1992;164():36-42; discussion 43-9.
1991: S J Stewart; G R Cunningham; J A Strupp; F S House; L L Kelley; G S Henderson; John H Exton; S B Bocckino
Activation of phospholipase D: a signaling system set in motion by perturbation of the T lymphocyte antigen receptor/CD3 complex.
Cell regulation 1991;2(10):841-50.
1991: J L Blank; A H Ross; John H Exton
Purification and characterization of two G-proteins that activate the beta 1 isozyme of phosphoinositide-specific phospholipase C. Identification as members of the Gq class.
The Journal of biological chemistry 1991;266(27):18206-16.
1991: S B Bocckino; P B Wilson; John H Exton
Phosphatidate-dependent protein phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6210-3.
1991: R L Wange; A V Smrcka; Paul C Sternweis; John H Exton
Photoaffinity labeling of two rat liver plasma membrane proteins with [32P]gamma-azidoanilido GTP in response to vasopressin. Immunologic identification as alpha subunits of the Gq class of G proteins.
The Journal of biological chemistry 1991;266(18):11409-12.
1991: John H Exton; S J Taylor; G Augert; S B Bocckino
Cell signalling through phospholipid breakdown.
Molecular and cellular biochemistry 1991;104(1-2):81-6.
1991: S J Taylor; H Z Chae; Sue Goo Rhee; John H Exton
Activation of the beta 1 isozyme of phospholipase C by alpha subunits of the Gq class of G proteins.
Nature 1991;350(6318):516-8.
1990: B Bouscarel; G Augert; S J Taylor; John H Exton
Alterations in vasopressin and angiotensin II receptors and responses during culture of rat liver cells.
Biochimica et biophysica acta 1990;1055(3):265-72.
1990: Z Georgoussi; S J Taylor; S B Bocckino; John H Exton
Purification of the hepatic vasopressin receptor using a novel affinity column.
Biochimica et biophysica acta 1990;1055(1):69-74.
1990: S J Taylor; jeffrey smith; John H Exton
Purification from bovine liver membranes of a guanine nucleotide-dependent activator of phosphoinositide-specific phospholipase C. Immunologic identification as a novel G-protein alpha subunit.
The Journal of biological chemistry 1990;265(28):17150-6.
1990: John H Exton
Signaling through phosphatidylcholine breakdown.
The Journal of biological chemistry 1990;265(1):1-4.
1990: John H Exton
Hormonal regulation of phosphatidylcholine breakdown.
Advances in second messenger and phosphoprotein research 1990;24():152-7.
1989: G Augert; S B Bocckino; Peter F Blackmore; John H Exton
Hormonal stimulation of diacylglycerol formation in hepatocytes. Evidence for phosphatidylcholine breakdown.
The Journal of biological chemistry 1989;264(36):21689-98.
1989: S B Bocckino; P B Wilson; John H Exton
An early elevation of diacylglycerol and phosphatidate in regenerating liver.
Biochemical and biophysical research communications 1989;164(1):290-4.
1989: S B Bocckino; P Wilson; John H Exton
An enzymatic assay for picomole levels of phosphatidate.
Analytical biochemistry 1989;180(1):24-7.
1989: C J Lynch; Peter F Blackmore; E H Johnson; R L Wange; P K Krone; John H Exton
Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. Immunodetection of Gs and Gi with antisera prepared against synthetic peptides.
The Journal of clinical investigation 1989;83(6):2050-62.
1989: G Augert; Peter F Blackmore; John H Exton
Changes in the concentration and fatty acid composition of phosphoinositides induced by hormones in hepatocytes.
The Journal of biological chemistry 1989;264(5):2574-80.
1989: S J Stewart; V Prpic; J A Johns; F S Powers; S E Graber; J T Forbes; John H Exton
Bacterial toxins affect early events of T lymphocyte activation.
The Journal of clinical investigation 1989;83(1):234-42.
1988: B Bouscarel; P B Wilson; Peter F Blackmore; C J Lynch; John H Exton
Agonist-induced down-regulation of the angiotensin II receptor in primary cultures of rat hepatocytes.
The Journal of biological chemistry 1988;263(29):14920-4.
1988: B Bouscarel; Peter F Blackmore; John H Exton
Characterization of the angiotensin II receptor in primary cultures of rat hepatocytes. Evidence that a single population is coupled to two different responses.
The Journal of biological chemistry 1988;263(29):14913-9.
1988: John H Exton
Mechanisms of action of calcium-mobilizing agonists: some variations on a young theme.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(11):2670-6.
1988: B Bouscarel; K Meurer; C Decker; John H Exton
The role of protein kinase C in the inactivation of hepatic glycogen synthase by calcium-mobilizing agonists.
The Biochemical journal 1988;251(1):47-53.
1988: G Augert; John H Exton
Insulin and oxytocin effects on phosphoinositide metabolism in adipocytes.
The Journal of biological chemistry 1988;263(8):3600-9.
1988: C J Lynch; S J Taylor; jeffrey smith; John H Exton
Formation of the high-affinity agonist state of the alpha 1-adrenergic receptor at cold temperatures does not require a G-protein.
FEBS letters 1988;229(1):54-8.
1988: Peter F Blackmore; C J Lynch; R J Uhing; T Fitzgerald; S B Bocckino; John H Exton
Role of guanine nucleotide regulatory proteins and inositol phosphates in the hormone induced mobilization of hepatocyte calcium.
Advances in experimental medicine and biology 1988;232():169-82.
1988: John H Exton
Role of phosphoinositides in the regulation of liver function.
Hepatology (Baltimore, Md.) 1988;8(1):152-66.
1987: C J Lynch; S B Bocckino; Peter F Blackmore; John H Exton
Calcium-mobilizing hormones and phorbol myristate acetate mediate heterologous desensitization of the hormone-sensitive hepatic Na+/K+ pump.
The Biochemical journal 1987;248(3):807-13.
1987: S J Taylor; John H Exton
Guanine-nucleotide and hormone regulation of polyphosphoinositide phospholipase C activity of rat liver plasma membranes. Bivalent-cation and phospholipid requirements.
The Biochemical journal 1987;248(3):791-9.
1987: S B Bocckino; P B Wilson; John H Exton
Ca2+-mobilizing hormones elicit phosphatidylethanol accumulation via phospholipase D activation.
FEBS letters 1987;225(1-2):201-4.
1987: John H Exton
Calcium signalling in cells--molecular mechanisms.
Kidney international. Supplement 1987;23():S68-81.
1987: S B Bocckino; Peter F Blackmore; P B Wilson; John H Exton
Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.
The Journal of biological chemistry 1987;262(31):15309-15.
1986: C J Lynch; P B Wilson; Peter F Blackmore; John H Exton
The hormone-sensitive hepatic Na+-pump. Evidence for regulation by diacylglycerol and tumor promoters.
The Journal of biological chemistry 1986;261(31):14551-6.
1986: S J Stewart; V Prpic; F S Powers; S B Bocckino; Russell Isaacks; John H Exton
Perturbation of the human T-cell antigen receptor-T3 complex leads to the production of inositol tetrakisphosphate: evidence for conversion from inositol trisphosphate.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(16):6098-102.
1985: R Charest; Peter F Blackmore; John H Exton
Characterization of responses of isolated rat hepatocytes to ATP and ADP.
The Journal of biological chemistry 1985;260(29):15789-94.
1985: C J Lynch; Peter F Blackmore; R Charest; John H Exton
The relationships between receptor binding capacity for norepinephrine, angiotensin II, and vasopressin and release of inositol trisphosphate, Ca2+ mobilization, and phosphorylase activation in rat liver.
Molecular pharmacology 1985;28(2):93-9.
1985: R Charest; V Prpić; John H Exton; Peter F Blackmore
Stimulation of inositol trisphosphate formation in hepatocytes by vasopressin, adrenaline and angiotensin II and its relationship to changes in cytosolic free Ca2+.
The Biochemical journal 1985;227(1):79-90.
1985: C J Lynch; R Charest; S B Bocckino; John H Exton; Peter F Blackmore
Inhibition of hepatic alpha 1-adrenergic effects and binding by phorbol myristate acetate.
The Journal of biological chemistry 1985;260(5):2844-51.
1985: C J Lynch; R Charest; Peter F Blackmore; John H Exton
Studies on the hepatic alpha 1-adrenergic receptor. Modulation of guanine nucleotide effects by calcium, temperature, and age.
The Journal of biological chemistry 1985;260(3):1593-600.
1984: N G Morgan; R Charest; Peter F Blackmore; John H Exton
Potentiation of alpha 1-adrenergic responses in rat liver by a cAMP-dependent mechanism.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(13):4208-12.
1983: Peter F Blackmore; B P Hughes; R Charest; E A Shuman; John H Exton
Time course of alpha1-adrenergic and vasopressin actions on phosphorylase activation, calcium efflux, pyridine nucleotide reduction, and respiration in hepatocytes.
The Journal of biological chemistry 1983;258(17):10488-94.
1983: R Charest; Peter F Blackmore; B Berthon; John H Exton
Changes in free cytosolic Ca2+ in hepatocytes following alpha 1-adrenergic stimulation. Studies on Quin-2-loaded hepatocytes.
The Journal of biological chemistry 1983;258(14):8769-73.
1982: N G Morgan; E A Shuman; John H Exton; Peter F Blackmore
Stimulation of hepatic glycogenolysis by alpha 1- and beta 2-adrenergic agonists. Evidence against short term agonist-induced desensitization of the responses.
The Journal of biological chemistry 1982;257(23):13907-10.
1982: Peter F Blackmore; B P Hughes; E A Shuman; John H Exton
alpha-Adrenergic activation of phosphorylase in liver cells involves mobilization of intracellular calcium without influx of extracellular calcium.
The Journal of biological chemistry 1982;257(1):190-7.